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https://www.readbyqxmd.com/read/29683421/targeting-macrophage-and-intestinal-epithelial-cell-specific-micrornas-against-norovirus-restricts-replication-in-vivo
#1
Lucy Thorne, Jia Lu, Yasmin Chaudhry, Dalan Bailey, Ian Goodfellow
Until recently, our understanding of the cellular tropism of human norovirus (HuNoV), a major cause of viral gastroenteritis, has been limited. Immune cells and intestinal epithelial cells (IECs) have been proposed as targets of HuNoV replication in vivo, although the contribution of each to pathogenesis and transmission is unknown. Murine norovirus (MNV) is widely used as a surrogate model for HuNoV, as it replicates in cultured immune cells. The importance of the complete MNV immune cell tropism in vivo has not been determined...
April 23, 2018: Journal of General Virology
https://www.readbyqxmd.com/read/29670823/identification-of-aberrant-circulating-mirnas-in-parkinson-s-disease-plasma-samples
#2
Lei Chen, Junxiu Yang, Jinhui Lü, Shanshan Cao, Qian Zhao, Zuoren Yu
Objective: To detect the aberrant expression of circulating miRNAs and explore the potential early diagnostic biomarkers in patients with Parkinson's disease (PD). Methods: Plasma samples were collected from 25 treatment-naïve PD-diagnosed patients and 25 healthy controls followed by a real-time PCR-based miRNA screening analysis of neuron disease-related miRNAs. Results: A subset of miRNAs with aberrant expression levels in the plasma of PD-diagnosed patients were identified including upregulation of miR-27a and downregulation of let-7a, let-7f, miR-142-3p, and miR-222 with the AUC values more than 0...
April 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29666503/regulatory-t-cell-derived-extracellular-vesicles-modify-dendritic-cell-function
#3
Sim L Tung, Dominic A Boardman, Monica Sen, Marilena Letizia, Qi Peng, Nicole Cianci, Laura Dioni, Leo M Carlin, Robert Lechler, Valentina Bollati, Giovanna Lombardi, Lesley A Smyth
Regulatory T cells (Treg) are a subpopulation of T cells that maintain tolerance to self and limit other immune responses. They achieve this through different mechanisms including the release of extracellular vesicles (EVs) such as exosomes as shown by us, and others. One of the ways that Treg derived EVs inhibit target cells such as effector T cells is via the transfer of miRNA. Another key target for the immunoregulatory function of Tregs is the dendritic cells (DCs). In this study we demonstrate directly, and for the first time, that miRNAs are transferred from Tregs to DCs via Treg derived EVs...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29643835/identification-of-neuroendocrine-stress-response-related-circulating-micrornas-as-biomarkers-for-type-2-diabetes-mellitus-and-insulin-resistance
#4
Ying-Zhi Liang, Jing Dong, Jie Zhang, Shuo Wang, Yan He, Yu-Xiang Yan
Background: Chronic stress plays an important role in the development of type 2 diabetes mellitus (T2DM) and insulin resistance (IR). MicroRNAs (miRNAs) play key roles in mediating stress responses by regulating the expression of target genes. This study systematically screened and identified the neuroendocrine stress response-related circulating miRNAs which are associated with T2DM and IR. Methods: Based on the differential plasma expression profiles between individuals with and without T2DM, stress-related miRNAs were selected from those differently expressed miRNAs whose targets are involved in known neuroendocrine pathway of stress response...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29620260/microrna%C3%A2-142%C3%A2-5p-modulates-breast-cancer-cell-proliferation-and-apoptosis-by-targeting-phosphatase-and-tensin-homolog
#5
Wenda Xu, Weixing Wang
A total of 60 breast cancer (BC) tissues and adjacent healthy tissues from patients who underwent surgery in Renmin Hospital of Wuhan University were collected for analysis in the present study. Results from reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) demonstrated that, compared with the adjacent healthy tissues, the expression levels of microRNA (miR)‑142‑5p were significantly elevated in BC tissues. Bioinformatics analysis was performed using TargetScan for the prediction of potential target sites that matched the seed region of miR‑142‑5p; phosphatase and tensin homolog (PTEN) exhibited the highest score and was selected for further analysis...
March 28, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29618746/mirna-142-3p-increases-radiosensitivity-in-human-umbilical-cord-blood-mononuclear-cells-by-inhibiting-the-expression-of-cd133
#6
Fang Yuan, Lu Liu, Yonghong Lei, Yi Hu
This study is to explore the molecular regulation mechanism of CD133 which is associated with malignancy and poor prognosis of blood system diseases. CD133+HUCB-MNC (human umbilical cord blood mononuclear cells) and CD133-HUCB-MNC were isolated and amplificated from umbilical cord blood, and then were exposed to different doses of radiation and subjected to a clonogenic assay. CCK-8 kit was used to detect cell viability, Annexin V-FITC/PI cell apoptosis detection kit was used for the detection of apoptotic cells and the BrdU assay was performed by flow cytometry...
April 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29590647/mir-142-3p-inhibits-tgf-%C3%AE-3-induced-blood-testis-barrier-impairment-by-targeting-lethal-giant-larvae-homolog-2
#7
Ying Xu, Weixing Wu, Yunxia Fan, Shuyi Jiang, Xiaoyu Jia, Wenhui Su
BACKGROUND/AIMS: Transforming growth factor-β3 (TGF-β3) has been proved to perturb the blood-testis barrier (BTB) by accelerating junction protein endocytosis in Sertoli cells (SCs) to accommodate the traversing of preleptotene spermatocytes across the BTB around stage VIII in rat. Yet the molecular network underlying the impairment of TGF-β3 on BTB integrity is not fully elucidated. Our study herein was designed to investigate the participation of microRNA-142-3p (miR-142-3p), which has been reported to affect TGF-β3 signaling via different pathways, during BTB dynamics and the corresponding mechanisms...
March 22, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29567372/a-six-microrna-signature-predicts-survival-of-patients-with-uterine-corpus-endometrial-carcinoma
#8
Yue Wang, Mu Xu, Qing Yang
Uterine corpus endometrial carcinoma (UCEC) is one of the most common female gynecological malignant tumors that threaten women health seriously. MicroRNAs (miRNAs) has been proved to play critical roles in tumor pathogenesis and malignant progression. In this study, we aimed to explore a novel signature of microRNA expression for predicting the overall survival (OS) of patients with UCEC. The genome-wide miRNA expression profiles and relevant clinical characteristics of 348 patients with UCEC were downloaded from the Cancer Genome Atlas (TCGA) data portal and analyzed comprehensively...
February 21, 2018: Current Problems in Cancer
https://www.readbyqxmd.com/read/29516510/integrated-analysis-of-long-noncoding-rna-associated-competing-endogenous-rna-network-in-periodontitis
#9
S Li, X Liu, H Li, H Pan, A Acharya, Y Deng, Y Yu, R Haak, J Schmidt, G Schmalz, D Ziebolz
BACKGROUND AND OBJECTIVES: Long noncoding RNAs (lncRNAs) play critical and complex roles in regulating various biological processes of periodontitis. This bioinformatic study aims to construct a putative competing endogenous RNA (ceRNA) network by integrating lncRNA, miRNA and mRNA expression, based on high-throughput RNA sequencing and microarray data about periodontitis. MATERIAL AND METHODS: Data from 1 miRNA and 3 mRNA expression profiles were obtained to construct the lncRNA-associated ceRNA network...
March 8, 2018: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29481306/platelet-derived-microparticles-promote-endothelial-cell-proliferation-in-hypertension-via-mir-142-3p
#10
Han Bao, Yuan-Xiu Chen, Kai Huang, Fei Zhuang, Min Bao, Yue Han, Xiao-Hu Chen, Qian Shi, Qing-Ping Yao, Ying-Xin Qi
Endothelial cells (ECs) are located at the interface between flowing blood and the vessel wall, and abnormal EC proliferation induced by pathologic environments plays an important role in vascular remodeling in hypertensive conditions. Exchanges of information between blood components and ECs are important for EC function. Hence, the present study sought to determine how platelets induce EC dysfunction under hypertensive conditions. EC proliferation was increased in renal hypertensive rats established by abdominal aortic coarctation compared with control rats and that elevated thrombin in plasma promoted platelet activation, which may induce the release of platelet-derived microparticles (PMPs)...
February 26, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29472524/pu-1-microrna-142-3p-targets-atg5-atg16l1-to-inactivate-autophagy-and-sensitize-hepatocellular-carcinoma-cells-to-sorafenib
#11
Kai Zhang, Jing Chen, Hao Zhou, Ying Chen, Yingru Zhi, Bei Zhang, Longbang Chen, Xiaoyuan Chu, Rui Wang, Chunni Zhang
Sorafenib is currently the only systemic agent approved for treatment of advanced hepatocellular carcinoma (HCC). However, intrinsic and acquired resistance to sorafenib remains a great challenge with respect to improving the prognoses of patients with HCC. The cyto-protective functions of autophagy have been suggested as a potential mechanism by which chemoresistance or targeted drug resistance occurs in tumour cells. In the present study, miR-142-3p was identified as a novel autophagy-regulating microRNA (miRNA) that plays a vital role in sorafenib resistance in HCC cells...
February 22, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29459719/mir-142-3p-regulates-autophagy-by-targeting-atg16l1-in-thymic-derived-regulatory-t-cell-ttreg
#12
Chuanyong Zhang, Hongbing Shen, Yunjie Lu, Ji Gao, Shaopeng Zhang, Jian Gu, Hao Lu, Yongxiang Xia, Qin Zhu, Xiaofeng Qian, Feng Zhang, Keli L Hippen, Bruce R Blazar, Ling Lu, Xuehao Wang
Thymic-derived regulatory T cell (tTreg) clinical trials show therapeutic promise in the prevention of acute graft-versus-host disease (GVHD) in allogeneic hematopoietic stem cell transplantation patients. However, strategies are needed to improve tTreg proliferative ability and survival as a means to improve tTreg therapy and reduce the requirement for producing large numbers of Treg cells for adoptive tTreg transfer. Autophagy is a self-degradative process for cytosolic components, which is involved in cells death, differentiation, lymphocyte homeostasis, and tTreg function...
February 19, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29458840/genome-wide-circulating-microrna-expression-profiling-reveals-potential-biomarkers-for-amyotrophic-lateral-sclerosis
#13
José Manuel Matamala, Raul Arias-Carrasco, Carolina Sanchez, Markus Uhrig, Leslie Bargsted, Soledad Matus, Vinicius Maracaja-Coutinho, Sebastian Abarzua, Brigitte van Zundert, Renato Verdugo, Patricio Manque, Claudio Hetz
The occurrence of mutations of TDP-43, FUS, and C9ORF72 in amyotrophic lateral sclerosis (ALS) suggests pathogenic alterations to RNA metabolism and specifically to microRNA (miRNA) biology. Moreover, several ALS-related proteins impact stress granule dynamics affecting miRNA biogenesis and cellular miRNA levels. miRNAs are present in different biological fluids and have been proposed as potential biomarkers. Here we used next-generation sequencing to perform a comparative analysis of the expression profile of circulating miRNAs in the serum of 2 mutant superoxide dismutase 1 transgenic mice...
April 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29455649/molecular-subtyping-of-nasopharyngeal-carcinoma-npc-and-a-microrna-based-prognostic-model-for-distant-metastasis
#14
Lan Zhao, Alvin H W Fong, Na Liu, William C S Cho
BACKGROUND: Nasopharyngeal carcinoma (NPC) is a highly invasive and metastatic cancer, with diverse molecular characteristics and clinical outcomes. This study aims to dissect the molecular heterogeneity of NPC, followed by the construction of a microRNA (miRNA)-based prognostic model for prediction of distant metastasis. METHODS: We retrieved two NPC datasets: GSE32960 and GSE70970 as training and validation cohorts, respectively. Consensus clustering was employed for cluster discovery, and support vector machine was used to build a classifier...
February 19, 2018: Journal of Biomedical Science
https://www.readbyqxmd.com/read/29440068/molecular-characterization-of-renal-cell-carcinoma-a-potential-three-microrna-prognostic-signature
#15
Soum D Lokeshwar, Asif Talukder, Travis J Yates, Martin J P Hennig, Michael Garcia-Roig, Sarrah S Lahorewala, Naureen N Mullani, Zachary Klaassen, Bruce R Kava, Murugesan Manoharan, Mark S Soloway, Vinata B Lokeshwar
Background: Aberrantly expressed miRNAs promote renal cell carcinoma (RCC) growth and metastasis and are potentially useful biomarkers for metastatic disease. However, a consensus clinically significant miRNA signature has not been identified. To identify an miRNA signature for predicting clinical outcome in RCC patients, we used a four-pronged interconnected approach. Methods: Differentially expressed miRNAs were identified and analyzed in 113 specimens (normal kidney: 59; tumor: 54). miRNA profiling was performed in matched normal and tumor specimens from 8 patients and extended to 32 specimens...
February 12, 2018: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29435179/identifying-characteristic-mirnas-genes-and-risk-pathways-of-multiple-sclerosis-based-on-bioinformatics-analysis
#16
Deling Luo, Jin Fu
Multiple sclerosis is a chronic autoimmune disorder of the central nervous system. In MS, the genetic susceptibility is high and currently there is no effective treatment. MicroRNA, a small non-coding RNA, plays a vital role in immune responses. Aberrant or dysfunctional miRNAs may cause several diseases, including MS, thus miRNAs and miRNA related genes may be therapeutic weapons against MS. Here, we identified 21 miRNAs in peripheral blood mono-nuclear cells from over 600 persons, including healthy controls...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29398246/corrigendum-to-mir-142-5p-promotes-development-of-colorectal-cancer-through-targeting-sdhb-and-facilitating-generation-of-aerobic-glycolysis-biomed-pharmacother-92-2017-1119-1127
#17
Shaojun Liu, Zhiming Xiao, Feiyan Ai, Fen Liu, Xiong Chen, Ke Cao, Weiguo Ren, Xuemei Zhang, Peng Shu, Decai Zhang
No abstract text is available yet for this article.
February 2, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29383581/genome-wide-microrna-profiling-of-bovine-milk-derived-exosomes-infected-with-staphylococcus-aureus
#18
Mingcheng Cai, Hongbing He, Xianbo Jia, Shiyi Chen, Jie Wang, Yu Shi, Buwei Liu, Wudian Xiao, Songjia Lai
Bovine milk is rich in exosomes, which contain abundant miRNAs and play important roles in the regulation of neonatal growth and development of adaptive immunity. Here, we analyzed miRNA expression profiles of bovine milk exosomes from three healthy and three mastitic cows, and then six miRNA libraries were constructed. Interestingly, we detected no scRNAs and few snRNAs in milk exosomes; this result indicated a potential preference for RNA packaging in milk exosomes. A total of 492 known and 980 novel exosomal miRNAs were detected, and the 10 most expressed miRNAs in the six samples accounted for 80-90% of total miRNA-associated reads...
January 30, 2018: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/29378472/discriminatory-mirnas-for-the-management-of-papillary-thyroid-carcinoma-and-noninvasive-follicular-thyroid-neoplasms-with-papillary-like-nuclear-features
#19
Iman Jahanbani, Abeer Al-Abdallah, Rola H Ali, Nabeel Al-Brahim, Olusegun Mojiminiyi
BACKGROUND: Papillary thyroid carcinoma (PTC) variants have several overlapping clinical and pathological features. The World Health Organization recently published a new classification of thyroid tumors containing significant revisions. Encapsulated papillary thyroid carcinoma (EPTC) has been recognized as a distinctive variant of PTC. The noninvasive encapsulated follicular variant of PTC has been reclassified as noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP)...
March 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29360449/mir-142-3p-inhibits-aerobic-glycolysis-and-cell-proliferation-in-hepatocellular-carcinoma-via-targeting-ldha
#20
Shengni Hua, Chengdong Liu, Li Liu, Dehua Wu
Cancer cells are addictively dependent on glycolysis even in an oxygen-rich condition. However, the mechanism underlying micro (mi)RNA regulation of aerobic glycolysis in cancer cells has not been fully understood. Here, we demonstrated that the expression of miR-142-3p was lower in hepatocellular carcinoma (HCC) as compared to adjacent non-tumor samples, which was confirmed in The Cancer Genome Atlas (TCGA) HCC cohorts and Gene Expression Omnibus (GEO) datasets. Function and pathway analysis showed that miR-142-3p was most relevent with metabolism...
February 12, 2018: Biochemical and Biophysical Research Communications
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