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https://www.readbyqxmd.com/read/29021740/electroacupuncture-alleviates-surgical-trauma-induced-hypothalamus-pituitary-adrenal-axis-hyperactivity-via-microrna-142
#1
Jing Zhu, Zhejun Chen, Zehui Meng, Minda Ju, Mizhen Zhang, Gencheng Wu, Haidong Guo, Zhanzhuang Tian
Electroacupuncture (EA) could improve the hyperactivity of the hypothalamus pituitary adrenal (HPA) axis induced by hepatectomy. However, its underlying mechanism still remains largely unclear. Here, we found that hypothalamic corticotrophin releasing hormone (CRH) modulates the function of the HPA axis, while hepatectomy induced an HPA axis disorder and EA application could regulate the hypothalamic CRH. We first demonstrated that microRNAs (miRNAs) target on CRH via bioinformatics analysis and screened them in the primary hypothalamic neurons...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28993242/a-distinct-microrna-expression-profile-is-associated-with-%C3%AE-11-c-methyl-l-tryptophan-amt-pet-uptake-in-epileptogenic-cortical-tubers-resected-from-patients-with-tuberous-sclerosis-complex
#2
Shruti Bagla, Daniela Cukovic, Eishi Asano, Sandeep Sood, Aimee Luat, Harry T Chugani, Diane C Chugani, Alan A Dombkowski
Tuberous sclerosis complex (TSC) is characterized by hamartomatous lesions in various organs and arises due to mutations in the TSC1 or TSC2 genes. TSC mutations lead to a range of neurological manifestations including epilepsy, cognitive impairment, autism spectrum disorders (ASD), and brain lesions that include cortical tubers. There is evidence that seizures arise at or near cortical tubers, but it is unknown why some tubers are epileptogenic while others are not. We have previously reported increased tryptophan metabolism measured with α[(11)C]-methyl-l-tryptophan (AMT) positron emission tomography (PET) in epileptogenic tubers in approximately two-thirds of patients with tuberous sclerosis and intractable epilepsy...
October 7, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28977934/shuanghuang-shengbai-granule-cures-myelosuppression-and-suppresses-lung-cancer-progression-mechanism-and-therapeutic-targets-from-the-aspect-of-micrornas
#3
Shuang Wang, Zhenye Xu, Lifang Wang
BACKGROUND: Shuanghuang Shengbai granule is effective in curing cyclophosphamide-induced myelosuppression without promoting lung cancer development. This study aims to investigate its mechanism and therapeutic targets. METHODS: Nude mice with lung cancer were treated with physiological saline (control), cyclophosphamide, or cyclophosphamide + Shuanghuang Shengbai. MicroRNA microarray was used to investigate the differentially expressed microRNAs in lung cancer stem cells or bone marrow hematopoietic stem cells between the three groups...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28976967/a-viral-sm-class-rna-base-pairs-with-mrnas-and-recruits-micrornas-to-inhibit-apoptosis
#4
Carlos Gorbea, Tim Mosbruger, Demián Cazalla
Viruses express several classes of non-coding RNAs; the functions and mechanisms by which most of these act are unknown. Herpesvirus saimiri, a γ-herpesvirus that establishes latency in the T cells of New World primates and has the ability to cause aggressive leukaemias and lymphomas in non-natural hosts, expresses seven small nuclear uracil-rich non-coding RNAs (called HSURs) in latently infected cells. These HSURs associate with Sm proteins, and share biogenesis and structural features with cellular Sm-class small nuclear RNAs...
October 12, 2017: Nature
https://www.readbyqxmd.com/read/28970833/differential-expression-of-micrornas-in-leprosy-skin-lesions
#5
Cleverson T Soares, Ana P F Trombone, Luciana R V Fachin, Patricia S Rosa, Cássio C Ghidella, Rodrigo F Ramalho, Mabel G Pinilla, Alex F Carvalho, Dirce N Carrara, Fernando A Soares, Andrea F F Belone
Leprosy, a chronic infectious disease caused by Mycobacterium leprae, is a major public health problem in poor and developing countries of the Americas, Africa, and Asia. MicroRNAs (miRNAs), which are small non-coding RNAs (18-24 nucleotides), play an important role in regulating cell and tissue homeostasis through translational downregulation of messenger RNAs (mRNAs). Deregulation of miRNA expression is important for the pathogenesis of various neoplastic and non-neoplastic diseases and has been the focus of many publications; however, studies on the expression of miRNAs in leprosy are rare...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28968594/mirna-expression-profile-of-the-myocardial-tissue-of-pigs-with-coronary-microembolization
#6
Qiang Su, Lang Li, Jinmin Zhao, Yuhan Sun, Huafeng Yang
BACKGROUND/AIMS: Coronary microembolization (CME) is a serious complication of coronary heart disease and is considered as a strong predictor of poor long-term prognosis and major cardiac adverse events. Here, we identified differentially expressed microRNAs (miRNAs) in the myocardial tissue of CME pigs, and predicted and analyzed the possible functions of their target genes. METHODS: Twelve Bama mini-pigs were randomly assigned to the sham and CME group (n = 6 in each group)...
October 2, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28963738/loss-of-function-of-mir-142-by-hypermethylation-promotes-tgf-%C3%AE-mediated-tumour-growth-and-metastasis-in-hepatocellular-carcinoma
#7
Qiangfeng Yu, Leyang Xiang, Libo Yin, Xincheng Liu, Dinghua Yang, Jianyin Zhou
OBJECTIVES: Hypermethylation-induced epigenetic silencing of tumour suppressor genes (TSGs) are frequent events during carcinogenesis. MicroRNA-142 (miR-142) is found to be dysregulated in cancer patients to participate into tumour growth, metastasis and angiogenesis. However, the tumour suppressive role of miR-142 and the status of methylation are not fully understood in hepatocellular carcinoma (HCC). METHODS: Hepatocellular carcinoma tissues and corresponding non-neoplastic tissues were collected...
September 30, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/28962835/identification-and-validation-of-the-microrna-response-elements-in-the-3-untranslated-region-of-the-udp-glucuronosyltransferase-ugt-2b7-and-2b15-genes-by-a-functional-genomics-approach
#8
Ioannis Papageorgiou, Michael H Court
Posttranscriptional repression of UDP-glucuronosyltransferase (UGT) 2B7 and 2B15 expression by microRNAs (miRNAs) may be an important mechanism underlying inter-individual variability in drug glucuronidation. Furthermore, the UGT2B15 3'-UTR contains a common SNP (rs3100) that could influence miRNA binding. The aim of this study was to identify the complete complement of miRNAs that could regulate UGT2B7 and UGT2B15 expression through binding to the reference and/or variant 3'-UTRs. Luciferase reporter plasmids containing either the reference or variant 3'-UTRs were screened against a 2,048 human miRNA library to identify those miRNAs that decrease luciferase activity by at least 30% when co-transfected into HEK293 cells...
September 28, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28912177/rac1-functions-downstream-of-mir-142-in-regulation-of-erythropoiesis
#9
Natali Rivkin, Elik Chapnik, Yehudit Birger, Eran Yanowski, Caterina Curato, Alexander Mildner, Ziv Porat, Gail Amir, Shai Izraeli, Steffen Jung, Eran Hornstein
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September 14, 2017: Haematologica
https://www.readbyqxmd.com/read/28880456/urinary-mir-155-5p-and-cxcl10-as-prognostic-and-predictive-biomarkers-of-rejection-graft-outcome-and-treatment-response-in-kidney-transplantation
#10
Olga Millán, Klemens Budde, Claudia Sommerer, Irene Aliart, Olesja Rissling, Beatriz Bardaji, Maaren Matz, Martin Zeier, Irene Silva, Lluis Guirado, Mercè Brunet
BACKGROUND AND PURPOSE: MicroRNAs (miRNAs) may be useful biomarkers of rejection and allograft outcome in kidney transplantation. Elevated urinary CXCL10 levels have been associated with acute rejection (AR) and may predict allograft failure. We examined the correlation of miRNA, CXCL10 levels and immunosuppressive drug exposure with AR and graft function in kidney transplant recipients. EXPERIMENTAL APPROACH: Eighty de novo kidney transplant recipients were recruited from four European centres...
September 7, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28866851/systematic-transcriptome-wide-analysis-of-mrna-mirna-interactions-reveals-the-involvement-of-mir-142-5p-and-its-target-foxo3-in-skeletal-muscle-growth-in-chickens
#11
Zhenhui Li, Bahareldin Ali Abdalla, Ming Zheng, Xiaomei He, Bolin Cai, Peigong Han, Hongjia Ouyang, Biao Chen, Qinghua Nie, Xiquan Zhang
The goal of this study was to perform a systematic transcriptome-wide analysis of mRNA-miRNA interactions and to identify candidates involved in the interplay between miRNAs and mRNAs that regulate chicken muscle growth. We used our previously published mRNA (GSE72424) and miRNA (GSE62971) deep sequencing data from two-tailed samples [i.e., the highest (h) and lowest (l) body weights] of Recessive White Rock (WRR) and Xinghua (XH) chickens to conduct integrative analyses of the miRNA-mRNA interactions involved in chicken skeletal muscle growth...
September 2, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/28857248/microrna-142-5p-induces-cancer-stem-cell-like-properties-of-cutaneous-squamous-cell-carcinoma-via-inhibiting-pten
#12
Xinping Bai, Yu Zhou, Ming Yang
Cutaneous squamous cell carcinoma (cSCC) is a malignancy of keratinocyte-derived skin tumor, which is regarded as the second most common skin cancer worldwide. Accumulating evidence has established that microRNAs (miRNAs) can play a critical role in tumor initiation, progression and metastasis including cSCC. Abnormal expression of hsa-miR-142-5p has been elaborated in various tumors. Nevertheless, its expression and function in the development of cSCC remain unclear. In our study, we found that the expression of hsa-miR-142-5p in cSCC cells were greatly overexpressed compared to human benign epidermal keratinocyte cells...
August 31, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28801229/immunomodulation-a-definitive-role-of-microrna-142
#13
REVIEW
Salil Sharma
Majority of microRNAs are evolutionarily conserved in vertebrates. This is suggestive of their similar roles in regulation of gene networks. In addition to their conserved mature sequences and regulatory roles, a few microRNAs show very cell or tissue specific expression. These microRNAs are highly enriched in some cell types or organs. One such microRNA is microRNA-142 (miR-142). The classical stem-loop structure of miR142 encodes for two species of mature microRNAs; miR142-5p and miR142-3p. MiR-142 is abundant in cells of hematopoietic origin, and therefore, aptly plays a role in lineage differentiation of hematopoietic cells...
August 9, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28794294/upregulated-expression-of-circulating-micrornas-in-kidney-transplant-recipients-with-interstitial-fibrosis-and-tubular-atrophy
#14
Sepideh Zununi Vahed, Ahmad Poursadegh Zonouzi, Hossein Ghanbarian, Moteza Ghojazadeh, Nasser Samadi, Mohammadreza Ardalan
INTRODUCTION: The discovery of circulating microRNAs (miRNAs), as potential noninvasive diagnostic biomarkers, has opened new avenues of research for identifying transplant patients with chronic allograft dysfunction. The present study aimed to investigate the expression levels of 4 immune-related miRNAs, miR-21, miR-31, miR-142-3p, and miR-155, in plasma samples of kidney allograft recipients. MATERIALS AND METHODS: The plasma expression levels of the miRNAs were evaluated by quantitative real-time polymerase chain reaction in 53 kidney recipients with long-term stable allograft function (n = 27), biopsy-proven interstitial fibrosis and tubular atrophy (n = 26), and healthy controls (n = 15)...
July 2017: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/28772218/suppression-of-microrna-142-5p-attenuates-hypoxia-induced-apoptosis-through-targeting-sirt7
#15
Liying Zhan, Shaoqing Lei, Wenlan Li, Yuan Zhang, Huaxin Wang, Yan Shi, Yulong Tian
Increasing study has suggested that microRNAs (miRNAs) are pivotal regulators in regulating hypoxia-induced injury. miR-142-5p has been suggested as a critical regulator for cellular survival. However, the role of miR-142-5p in regulating hypoxia-induced injury remains unknown. In this study, we aimed to investigate the mechanistic roles of miR-142-5p in regulating cell survival during hypoxia treatment using H9C2 cardiomyoblasts and primary cardiomyocytes. We showed that miR-142-5p expression level was significantly repressed by hypoxia treatment...
October 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28769761/identification-of-the-role-of-mir-142-5p-in-alzheimer-s-disease-by-comparative-bioinformatics-and-cellular-analysis
#16
Juhyun Song, Young-Kook Kim
Alzheimer's disease (AD) is the most common neurodegenerative disease characterized by the formation of amyloid beta (Aβ) or tau protein aggregates, the hallmark of cognitive decline. MicroRNAs (miRNAs) have emerged as critical factors in neurogenesis and synaptic functions in the central nervous system (CNS). Recent studies have reported alterations in miRNA expression in patients with AD. However, miRNAs associated with AD varied with patient groups or experimental models, suggesting the need for a comparative study to identify miRNAs commonly dysregulated in diverse AD models...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28754845/shuanghuang-shengbai-granule-cures-myelosuppression-and-suppresses-lung-cancer-progression-mechanism-and-therapeutic-targets-from-the-aspect-of-micrornas
#17
Shuang Wang, Zhenye Xu, Lifang Wang
BACKGROUND: Shuanghuang Shengbai granule is effective in curing cyclophosphamide-induced myelosuppression without promoting lung cancer development. This study aims to investigate its mechanism and therapeutic targets. METHODS: Nude mice with lung cancer were treated with physiological saline (control), cyclophosphamide, or cyclophosphamide + Shuanghuang Shengbai. MicroRNA microarray was used to investigate the differentially expressed microRNAs in lung cancer stem cells or bone marrow hematopoietic stem cells between the three groups...
July 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28740575/identification-of-novel-diagnostic-and-prognostic-mirna-signatures-in-endometrial-cancer
#18
Muralidharan Jayaraman, Rangasudhagar Radhakrishnan, Cara A Mathews, Mingda Yan, Sanam Husain, Katherine M Moxley, Yong Sang Song, Danny N Dhanasekaran
With the goal of identifying diagnostic and prognostic biomarkers in endometrial cancer, miRNA-profiling was carried out with formalin-fixed paraffin embedded (FFPE) tissue samples from 49 endometrial cancer patients. Results using an 84-cancer specific miRNA panel identified the upregulation of miR-141-3p and miR-96-5p along with a downregulation of miR-26, miR-126-3p, miR-23b, miR-195-5p, miR-374a and let-7 family of miRNAs in endometrial cancer. We validated the dysregulated expression of the identified miRNAs in a panel of endometrial cancer cell-lines...
May 2017: Genes & Cancer
https://www.readbyqxmd.com/read/28739526/chronic-mild-stress-exacerbates-severity-of-experimental-autoimmune-encephalomyelitis-in-association-with-altered-non-coding-rna-and-metabolic-biomarkers
#19
Brietta Gerrard, Vaibhav Singh, Olena Babenko, Isabelle Gauthier, V Wee Yong, Igor Kovalchuk, Artur Luczak, Gerlinde A S Metz
The causal factors determining the onset and severity of multiple sclerosis (MS) are not well understood. Here, we investigated the influence of chronic stress on clinical symptoms, metabolic and epigenetic manifestations of experimental autoimmune encephalomyelitis (EAE), a common animal model of MS. Lewis rats were immunized for monophasic EAE with MBP69-88 and were exposed to chronic stress for 37days starting 7days prior to immunization. The exposure to stress accelerated and exacerbated the clinical symptoms of EAE...
July 21, 2017: Neuroscience
https://www.readbyqxmd.com/read/28733034/decreased-expression-of-mir-150-mir146a-and-mir424-in-type-1-diabetic-patients-association-with-ongoing-islet-autoimmunity
#20
Guofeng Wang, Yong Gu, Ning Xu, Mei Zhang, Tao Yang
BACKGROUND: Recent studies revealed altered miRNAs profiling in patients with autoimmune diseases, including type 1 diabetes (T1D). Here, we conducted an observational study and examined the expression levels of these five miRNAs (miR-150,miR-146a,miR-424,miR-181a and miR-142-3P) in peripheral blood mononuclear cells (PBMCs) from T1D patients. METHODS: PBMCs were obtained from T1D cohorts (n = 78), type 2 diabetes (T2D, n = 46) and healthy control subjects (n = 56)...
July 18, 2017: Biochemical and Biophysical Research Communications
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