keyword
MENU ▼
Read by QxMD icon Read
search

miR-142

keyword
https://www.readbyqxmd.com/read/27920149/mir-142-3p-is-a-key-regulator-of-il-1%C3%AE-dependent-synaptopathy-in-neuroinflammation
#1
Georgia Mandolesi, Francesca De Vito, Alessandra Musella, Antonietta Gentile, Silvia Bullitta, Diego Fresegna, Helena Sepman, Claudio Di Sanza, Nabila Haji, Francesco Mori, Fabio Buttari, Emerald Perlas, Maria Teresa Ciotti, Eran Hornstein, Irene Bozzoni, Carlo Presutti, Diego Centonze
: MicroRNAs (miRNA) play an important role in posttranscriptional gene regulation of several physiological and pathological processes. In multiple sclerosis (MS), a chronic inflammatory and degenerative disease of the CNS, and in its mouse model, the experimental autoimmune encephalomyelitis (EAE), miRNA dysregulation has been mainly related to immune system dysfunction and white matter pathology. However, little is known about their role in grey matter pathology. Here, we explored miRNA involvement in the inflammation-driven alterations of synaptic structure and function, collectively known as synaptopathy, a neuropathological process contributing to excitotoxic neurodegeneration in MS/EAE...
December 5, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27909218/erythrocyte-survival-is-controlled-by-microrna-142
#2
Natalia Rivkin, Elik Chapnik, Alexander Mildner, Gregory Barshtein, Ziv Porat, Elena Kartvelishvily, Tali Dadosh, Yehudit Birger, Gail Amir, Saul Yedgar, Shai Izraeli, Steffen Jung, Eran Hornstein
Hematopoietic-specific miR-142 is critical regulator of various blood cell lineages, but its role in erythrocytes is unexplored. Here, we characterize miR-142 impact on erythrocyte physiology and molecular cell biology, using a mouse loss of function allele. We report that miR-142 is required for maintaining the typical erythrocyte biconcave shape and structural resilience, for normal metabolism of reactive oxygen species (ROS) and for overall lifespan. miR-142 further controls actin filament homeostasis and membrane skeleton organization...
December 1, 2016: Haematologica
https://www.readbyqxmd.com/read/27894934/mir-142-is-required-for-staphylococcus-aureus-clearance-at-skin-wound-sites-via-small-gtpase-mediated-regulation-of-the-neutrophil-actin-cytoskeleton
#3
Katsuya Tanaka, Sang Eun Kim, Hiroki Yano, Gaku Matsumoto, Ryoma Ohuchida, Yuhoko Ishikura, Masatake Araki, Kimi Araki, Seongjoon Park, Toshimitsu Komatsu, Hiroko Hayashi, Kazuya Ikematsu, Katsumi Tanaka, Akiyoshi Hirano, Paul Martin, Isao Shimokawa, Ryoichi Mori
MicroRNAs (miRNAs) are small noncoding RNAs that regulate protein translation by binding to complementary target mRNAs. We previously identified two mature members of the miR-142 family, miR-142-5p and miR-142-3p, as inflammation-related miRNAs with potential roles in wound healing. Here, we demonstrated that these two miRNAs are prominently expressed in wound-infiltrated neutrophils and macrophages and play central roles in wound healing. We generated miR-142(-/-) mice using the exchangeable gene-trap method and showed that healing of Staphylococcus aureus-infected skin wounds was significantly delayed in miR-142(-/-) mice compared with that in wild-type mice...
November 25, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27884048/microrna-142-is-a-multifaceted-regulator-in-organogenesis-homeostasis-and-disease
#4
REVIEW
A Shrestha, R T Mukhametshina, S Taghizadeh, E Vásquez-Pacheco, H Cabrera-Fuentes, A Rizvanov, B Mari, G Carraro, S Bellusci
Over the last decade, microRNA-142 (miR-142) is emerging as a major regulator of cell fate decision in the hematopoietic system. However, miR-142 is expressed in many other tissues and recent evidence suggest that it may play a more pleiotropic role during embryonic development. In addition, miR-142 has been shown to play important functions in disease. miR-142 displays a functional role in cancer, virus infection, inflammation and immune tolerance. Both a guide strand (miR-142-3p) and passenger strand (miR-142-5p) are generated from the miR-142 hairpin...
November 24, 2016: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/27883021/identification-of-aberrant-trna-halves-expression-patterns-in-clear-cell-renal-cell-carcinoma
#5
Malin Nientiedt, Mario Deng, Doris Schmidt, Sven Perner, Stefan C Müller, Jörg Ellinger
Small non-coding RNAs (sncRNA; <200 nt) regulate various cellular processes and modify gene expression. Under nutritional, biological or physiochemical stress some mature sncRNAs (e.g. tRNAs) are cleaved into halves (30-50 nt) and smaller fragments (18-22 nt); the significance and functional role of these tRNA fragments is unknown, but their existence has been linked to carcinogenesis. We used small RNA sequencing to determine the expression of sncRNAs. Subsequently the findings were validated for miR-122-5p, miR-142-3p and 5'tRNA4-Val-AAC using qPCR...
November 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27870736/lidocaine-administration-controls-micrornas-alterations-observed-after-lung-ischemia-reperfusion-injury
#6
Lisa Rancan, Carlos Simón, Emmeline Marchal-Duval, Javier Casanova, Sergio Damian Paredes, Alberto Calvo, Cruz García, David Rincón, Agustín Turrero, Ignacio Garutti, Elena Vara
BACKGROUND: Ischemia-reperfusion injury (IRI) is associated with morbidity and mortality. MicroRNAs (miRNAs) have emerged as regulators of IRI, and they are involved in the pathogenesis of organ rejection. Lidocaine has proven anti-inflammatory activity in several tissues but its modulation of miRNAs has not been investigated. This work aims to investigate the involvement of miRNAs in lung IRI in a lung auto-transplantation model and to investigate the effect of lidocaine. METHODS: Three groups (sham, control, and Lidocaine), each comprising 6 pigs, underwent a lung autotransplantation...
December 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27852285/elevated-expression-of-mir-142-3p-is-related-to-the-pro-inflammatory-function-of-monocyte-derived-dendritic-cells-in-sle
#7
Yilun Wang, Jun Liang, Haihong Qin, Yan Ge, Juan Du, Jinran Lin, Xiaohua Zhu, Jie Wang, Jinhua Xu
BACKGROUND: Recent studies have shown that alterations in the function of dendritic cells (DCs) are involved in the pathogenesis of systemic lupus erythematosus (SLE). However, the mechanism of the alteration remains unclear. METHODS: We cultured monocyte-derived DCs (moDCs) in vitro and examined the cytokines and chemokines in the supernatants of moDCs in negative controls (NC) and SLE patients in active phase. We then profiled microRNAs (miRNAs) of LPS-stimulated moDCs in SLE patients and used real-time PCR to verify the differentially expressed miRNAs...
November 16, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27829233/mir-142-inhibits-the-development-of-cervical-cancer-by-targeting-hmgb1
#8
Daqiong Jiang, Huiyan Wang, Zhuyan Li, Zhen Li, Xin Chen, Hongbing Cai
It has been reported that miRNAs is deregulated in diverse human cancers, involving human cervical cancer. However, the clinical significances and potential mechanisms of miR-142 in the development and progression of cervical cancer were not elucidated completely till now. In this study, we found that the expression of miR- 142 was obviously down-regulated in human cervical cancer tissues and a panel of cell lines. According to statistics, the expression of miR-142 was negatively related to advanced FIGO stage and lymphatic metastasis (p < 0...
November 5, 2016: Oncotarget
https://www.readbyqxmd.com/read/27821865/identification-of-suitable-reference-gene-and-biomarkers-of-serum-mirnas-for-osteoporosis
#9
Jian Chen, Kai Li, Qianqian Pang, Chao Yang, Hongyu Zhang, Feng Wu, Hongqing Cao, Hongju Liu, Yumin Wan, Weibo Xia, Jinfu Wang, Zhongquan Dai, Yinghui Li
Our objective was to identify suitable reference genes in serum miRNA for normalization and screen potential new biomarkers for osteoporosis diagnosis by a systematic study. Two types of osteoporosis models were used like as mechanical unloading and estrogen deficiency. Through a large-scale screening using microarray, qPCR validation and statistical algorithms, we first identified miR-25-3p as a suitable reference gene for both type of osteoporosis, which also showed stability during the differentiation processes of osteoblast and osteoclast...
November 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27802180/the-aberrant-expression-of-micrornas-and-correlations-with-t-cell-subsets-in-patients-with-immune-thrombocytopenia
#10
Lu Liu, Mingqiang Hua, Chuanfang Liu, Na He, Zhao Li, Daoxin Ma
Both microRNAs and T helper (Th) cells involve in autoimmune diseases and their effects and interactions in immune thrombocytopenia (ITP) remain unclear. In the present study, we investigated the expression profiles of seven immune-related microRNAs (miR-155, 146a, 326, 142-3p, 17-5p, 21 and 181a) and the frequencies of four Th cells (Th1, Th2, Th17 and Treg) in peripheral blood mononuclear cell (PBMCs) of ITP patients and healthy controls. Platelet autoantibodies specific for GPIIb/IIIa or GPIb/IX were measured using MAIPA method...
October 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/27799333/micrornas-modulate-pathogenesis-resulting-from-chlamydial-infection-in-mice
#11
Laxmi Yeruva, Dakota Pouncey, Michael R Eledge, Sudeepa Bhattacharya, Chunqiao Luo, Erin W Weatherford, David M Ojcius, Roger G Rank
Not all women infected with chlamydiae develop upper genital tract disease, but the reason(s) for this remain undefined. Host genetics and hormonal changes associated with the menstrual cycle are possible explanations for variable infection outcomes. It is also possible that disease severity depends on the virulence of the chlamydial inoculum. It is likely that the inoculum contains multiple genetic variants, differing in virulence. If the virulent variants dominate, then the individual is more likely to develop severe disease...
October 31, 2016: Infection and Immunity
https://www.readbyqxmd.com/read/27796811/differential-expression-of-mirnas-in-the-seminal-plasma-and-serum-of-testicular-cancer-patients
#12
Marianna Pelloni, Giulia Coltrinari, Donatella Paoli, Francesco Pallotti, Francesco Lombardo, Andrea Lenzi, Loredana Gandini
Various microRNAs from the miR-371-3 and miR-302a-d clusters have recently been proposed as markers for testicular germ cell tumours. Upregulation of these miRNAs has been found in both the tissue and serum of testicular cancer patients, but they have never been studied in human seminal plasma. The aim of this study was, therefore, to assess the differences in the expression of miR-371-3 and miR-302a-d between the seminal plasma and serum of testicular cancer patients, and to identify new potential testicular cancer markers in seminal plasma...
October 28, 2016: Endocrine
https://www.readbyqxmd.com/read/27796281/epstein-barr-virus-ebv-bamhi-a-rightward-transcript-bart-6-and-cellular-microrna-142-synergistically-compromise-immune-defense-of-host-cells-in-ebv-positive-burkitt-lymphoma
#13
Ling Zhou, Yunwen Bu, Yanyan Liang, Fang Zhang, Haiguo Zhang, Shumei Li
BACKGROUND This study was designed to explore the molecular mechanism underlying the effect of cellular miRNAs and EBV miRNA upon the expression of targets such as PTEN, and their involvement in the pathogenesis of Burkitt lymphoma. MATERIAL AND METHODS In this study, we examined several differentially expressed cellular miRNAs in EBV-positive versus EBV-negative Burkett lymphoma tissue samples, and confirmed PTEN as targets of cellular miR-142 by using a bioinformatics tool, luciferase reporter system, oligo transfection, real-time PCR, and Western blot analysis...
October 31, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27793049/ultraviolet-radiation-induced-differential-microrna-expression-in-the-skin-of-hairless-skh1-mice-a-widely-used-mouse-model-for-dermatology-research
#14
Ashok Singh, Estelle Willems, Anupama Singh, Irene M Ong, Ajit K Verma
Cutaneous squamous cell carcinoma (cSCC) is the most common type of non-melanoma skin cancer that can metastasize. The major etiological factor associated with cSCC is Ultraviolet radiation (UVR) with a limited understanding of its molecular mechanism. It was hypothesized that there is a direct effect of UVR on modulation of microRNAs (miRNAs), a novel class of short noncoding RNAs which affects translation and stability of mRNAs. To test the hypothesis, the dorsal skin of the SKH1 mice (6-7 week old) was exposed to acute and chronic doses of UVR...
October 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/27788393/downregulated-expression-of-mir-142-3p-in-macrophages-contributes-to-increased-il-6-levels-in-aged-mice
#15
Yin Liu, Xiaoqi Song, Shu Meng, Minghong Jiang
Macrophages are innate immune cells that are important contributors to age-related functional impairment of the immune system. During the cell aging process, microRNAs are differentially expressed and participate in the regulation of aging-related immune responses. However, the role of aging-associated changes in miRNA expression in macrophages remains unclear. Here, we found that miR-142-3p expression is downregulated 50% in peritoneal macrophages from aged mice compared with young mice and is not upregulated by cell treatment with lipopolysaccharide (LPS), CpG, or polyinosinic-polycytidylic acid...
December 2016: Molecular Immunology
https://www.readbyqxmd.com/read/27775779/microrna-142-promotes-the-expression-of-enos-in-human-peripheral-blood-derived-endothelial-progenitor-cells-in-vitro
#16
H-W Zhang, H Li, H Yan, B-L Liu
OBJECTIVE: MicroRNAs (miRNAs) are small non-coding RNAs (18-25nt) that regulate gene expression mainly through affecting post-transcriptional modification. In this research, the human peripheral blood-derived endothelial progenitor cells were isolated to research the inter-coordination of miR-142, ADAMTS-1, VEGF and eNOS through gene over-expressed in EPCs. MATERIALS AND METHODS: Endothelial progenitor cells (EPCs) were isolated from human peripheral blood, and demonstrate the interaction of miR-142 and targets (ADAMTS-1) in vitro...
October 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27709720/differential-micro-ribonucleic-acid-expression-profiling-in-ovarian-endometrioma-with-leuprolide-acetate-treatment
#17
Atsushi Kiba, Kouji Banno, Megumi Yanokura, Mari Asada, Yusuke Nakayama, Daisuke Aoki, Tatsuya Watanabe
AIM: Micro ribonucleic acids (miRNAs) play an important pathological role in endometriosis. Leuprolide acetate, an analog of gonadotropin-releasing hormone, is widely used to treat endometriosis; however, the molecular mechanisms involved in endometriotic tissue regression remain unclear. We performed miRNA expression profiling of clinical ovarian endometrioma to obtain insight into the effects of leuprolide acetate treatment. METHODS: We obtained clinical samples from nine normal eutopic endometrium, eight ovarian endometriotic, and 12 leuprolide acetate-treated endometriotic tissues...
October 6, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27683030/microrna-regulatory-pathway-analysis-identifies-mir-142-5p-as-a-negative-regulator-of-tgf-%C3%AE-pathway-via-targeting-smad3
#18
Zhaowu Ma, Teng Liu, Wei Huang, Hui Liu, Hong-Mei Zhang, Qiubai Li, Zhichao Chen, An-Yuan Guo
MicroRNAs (miRNAs) are non-coding RNAs with functions of posttranscriptional regulation. The abnormally expressed miRNAs have been shown to be crucial contributors and may serve as biomarkers in many diseases. However, determining the biological function of miRNAs is an ongoing challenge. By combining miRNA targets prediction, miRNA and mRNA expression profiles in TCGA cancers, and pathway data, we performed a miRNA-pathway regulation inference by Fisher's exact test for enrichment analysis. Then we constructed a database to show the cancer related miRNA-pathway regulatory network (http://bioinfo...
September 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/27680012/abnormal-serum-microrna-profiles-in-tuberous-sclerosis-are-normalized-during-treatment-with-everolimus-possible-clinical-implications
#19
Joanna Trelinska, Wojciech Fendler, Iwona Dachowska, Katarzyna Kotulska, Sergiusz Jozwiak, Karolina Antosik, Piotr Gnys, Maciej Borowiec, Wojciech Mlynarski
BACKGROUND: Tuberous sclerosis (TSC) is a monogenic disease resulting from defects of the TSC1 or TSC2 genes, which encode the proteins forming hamartin-tuberin tumor suppressor complex, the mammalian target of rapamycin complex (mTOR). The mTOR pathway is constitutively activated in response to tuberin or hamartin defects. The mTOR pathway is also regulated by a multitude of epigenetic mechanisms, one of which is regulation by microRNA (miRNA) inhibition. This leads us to hypothesize that organ-level abnormalities of miRNA expression patterns are widespread in TSC...
September 29, 2016: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/27664382/a-mirna-target-network-putatively-involved-in-follicular-atresia
#20
F X Donadeu, B T Mohammed, J Ioannidis
In a previous microarray study, we identified a subset of micro RNAS (miRNAs), which expression was distinctly higher in atretic than healthy follicles of cattle. In the present study, we investigated the involvement of those miRNAs in granulosa and theca cells during atresia. Reverse Transcription-quantitative Polymerase Chain Reaction (RT-qPCR) confirmed that miR-21-5p/-3p, miR-150, miR-409a, miR-142-5p, miR-378, miR-222, miR-155, and miR-199a-5p were expressed at higher levels in atretic than healthy follicles (9-17 mm, classified based on steroidogenic capacity)...
January 2017: Domestic Animal Endocrinology
keyword
keyword
31605
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"