keyword
MENU ▼
Read by QxMD icon Read
search

Il-35

keyword
https://www.readbyqxmd.com/read/29775441/-the-biological-function-and-significance-of-il-35-in-the-pathogenesis-of-atherosclerosis
#1
EDITORIAL
Mateusz Staciwa, Marlena Broncel
The imbalance of anti-inflammatory /pro- inflammatory cytokines plays an important role in the progression of atherosclerosis. Interleukin 35 (IL-35) is a novel member of the IL-12 family, consisting of an EBVinduced gene 3 (EBI3) subunit and a P35 subunit. IL-35 is an immunesuppressive cytokine mainly produced by regulatory T cells. Accumulating evidence suggests that IL-35 may represent a target for antiatherosclerotic therapy based on its several anti-inflammatory features. This review provide a brief overview of IL-35 biology and the role of IL-35 in the atherosclerosis, autoimmune disease and cancers...
April 23, 2018: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29749583/il-35-a-new-immunomodulator-in-autoimmune-rheumatic-diseases
#2
REVIEW
Lazaros I Sakkas, Athanasios Mavropoulos, Carlo Perricone, Dimitrios P Bogdanos
IL-35 is a relatively new cytokine that emerges as an important immunomodulator. IL-35 belongs to IL-12 cytokine family that includes IL-12, IL-23, IL-27, and IL-35. These cytokines are heterodimers that share subunits and their receptors also share subunits. Whereas IL-12 and IL-23 are clearly proinflammatory cytokines, the role of IL-35 is less clear. In mice, IL-35 appears to be anti-inflammatory and to protect from autoimmune inflammatory diseases. IL-35 induces the expansion of a subset of regulatory T cells (Tregs) and Bregs and mediates their suppressive function and inhibits Th17 cells...
May 11, 2018: Immunologic Research
https://www.readbyqxmd.com/read/29742730/il-35-producing-b-cells-in-gastric-cancer-patients
#3
Ke Wang, Jianming Liu, Jiansheng Li
A significant characteristic of advanced gastric cancer (GC) is immune suppression, which can promote the progression of GC. Interleukin 35 (IL-35) is an immune-suppressing cytokine, and it is generally recognized that this cytokine is secreted by regulatory T (Treg) cells. Recently, studies have found that IL-35 can also be produced by B cells in mice. However, scientific studies reporting that IL-35 is secreted by B cells in humans, specifically in cancer patients, are very rare.Blood samples were collected from 30 healthy controls (HCs) and 50 untreated GC patients, and IL-35-producing B cells in the peripheral blood were investigated...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29739077/circulating-levels-of-il-35-and-gene-expression-of-foxp3-in-coronary-artery-disease-is-there-any-interplay-between-them-and-25-hydroxyvitamin-d3
#4
Hossein Shateri, Reza Fadaei, Mahdi Najafi, Akram Vatannejad, Maryam Teimouri, Fatemeh Zali, Solaleh Emamgholipour, Eskandar Parvaz, Mostafa Asadnia, Mahmood Doosti
BACKGROUND: We aimed to evaluate interleukin-35 (IL-35) serum levels and the forkhead box P3 (FoxP3) expression in peripheral blood mononuclear cells (PBMCs) of coronary artery disease (CAD) patients compared with the non-CAD group. Also, we examined the possible relationship between gene expression of FoxP3 and serum levels of IL-35 with several CAD-related clinical parameters. METHODS: This study was conducted on 40 men with CAD and 40 men with a normal coronary artery...
April 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29738342/association-between-interleukin-35-polymorphisms-and-coronary-heart-disease-in-the-chinese-zhuang-population-a-case-control-study
#5
Yingzhong Lin, Yan Xue, Xinshun Huang, Jianyong Lu, Zicong Yang, Jing Ye, Shu Zhang, Ling Liu, Yu Liu, Ying Shi
OBJECTIVES: Inflammatory cytokines play an important role in the pathogenesis of cardiovascular disease. Few studies have investigated the association between interleukin-35 (IL-35) genetic variants and the risk of coronary heart disease (CHD). We examined the association between IL-35 polymorphisms and CHD in the Chinese Zhuang population. PATIENTS AND METHODS: A total of 707 CHD patients and 707 age-matched and sex-matched controls were enrolled in this case-control study...
May 5, 2018: Coronary Artery Disease
https://www.readbyqxmd.com/read/29729445/emerging-role-of-il-35-in-inflammatory-autoimmune-diseases
#6
REVIEW
Lin-Chong Su, Xiao-Yan Liu, An-Fang Huang, Wang-Dong Xu
Interleukin 35 (IL-35) is the recently identified member of the IL-12 family of cytokines and provides the possibility to be a target for new therapies for autoimmune, inflammatory diseases. It is composed of an α chain (p35) and a β chain (EBI3). IL-35 mediates signaling by binding to its receptors, activates subsequent signaling pathways, and therefore, regulates the differentiation, function of T, B cells, macrophages, dendritic cells. Recent findings have shown abnormal expression of IL-35 in inflammatory autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, type 1 diabetes, psoriasis, multiple sclerosis, autoimmune hepatitis, experimental autoimmune uveitis...
May 3, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29721156/pro-tumoral-immune-cell-alterations-in-wild-type-and-shb-deficient-mice-in-response-to-4t1-breast-carcinomas
#7
Xiujuan Li, Kailash Singh, Zhengkang Luo, Mariela Mejia-Cordova, Maria Jamalpour, Björn Lindahl, Ganlin Zhang, Stellan Sandler, Michael Welsh
To assess mechanisms responsible for breast carcinoma metastasis, 4T1 breast carcinomas were grown orthotopically in wild type or Shb knockout mice. Tumor growth, metastasis, vascular characteristics and immune cell properties were analyzed. Absence of Shb did not affect tumor growth although it increased lung metastasis. Shb knockout mouse tumors showed decreased redness and less developed vascular plexa located at the periphery of the tumors. No difference in overall tumor vascular density, leakage or pericyte coverage was noted between the genotypes although the average vessel size was smaller in the knockout...
April 10, 2018: Oncotarget
https://www.readbyqxmd.com/read/29701163/vitamin-d-status-in-coronary-artery-disease-association-with-il-35-and-tgf-%C3%AE-1-and-disease-severity
#8
Fereshteh Rasa, Nadereh Naderi, Ebrahim Eftekhar, Elahe Mansoori, Mahsa Rahimzadeh
BACKGROUND: The exact mechanisms underlying the protective effect of vitamin D in the pathogenesis of atherosclerosis and coronary heart disease is obscure. OBJECTIVE: Here, we have addressed the relation between vitamin D status and regulatory T cells (Tregs) inhibitory cytokines in patients suffering from coronary artery disease (CAD). MATERIALS AND METHODS: 81 patients were divided into single (n= 20), double (n=20) and triple (n=20) vessel disease groups and compared to no vessel disease (No VD) group (n=21)...
April 25, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29692871/allergic-rhinitis-and-its-relationship-with-il-10-il-17-tgf-%C3%AE-ifn-%C3%AE-il-22-and-il-35
#9
P Bayrak Degirmenci, S Aksun, Z Altin, F Bilgir, I B Arslan, H Colak, B Ural, D Solakoglu Kahraman, G Diniz, B Ozdemir, C Kırmaz
Background: We aimed in our study to research the role of new cytokines such as IL-35, IL-22, and IL-17 that may form a target for novel treatment approaches. Methods: IL-10, IL-17, TGF- β , IFN- γ , IL-22, and IL-35 serum levels of allergic rhinitis (AR) patients were measured using ELISA method. Allergic sensitization was demonstrated by the skin prick test. Patients only with olive tree sensitivity were evaluated for seasonal AR (SAR). Patients only with mite sensitivity were included in the study for perennial AR (PAR)...
2018: Disease Markers
https://www.readbyqxmd.com/read/29577513/placental-immune-state-shifts-with-gestational-age
#10
Emma L Lewis, Luz-Jeannette Sierra, Guillermo O Barila, Amy G Brown, Paige M Porrett, Michal A Elovitz
PROBLEM: Placental immunologic functions are implicated in both the maintenance of a healthy pregnancy and the pathogenesis of obstetric complications. Immune populations at the maternal-fetal interface are hypothesized to support fetomaternal tolerance, defend the fetus from infection, and contribute to labor initiation. Despite the many potential roles of placental immune cells in normal and abnormal pregnancy, little is known about placental immune population dynamics over gestation, particularly near parturition...
March 25, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29576585/interleukin-35-as-a-new-biomarker-of-renal-involvement-in-lupus-nephritis-patients
#11
Di He, Min Liu, Bo Liu
Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disease with a wide range of clinical presentations. Lupus nephritis (LN) is the most serious manifestation of SLE. Interleukin-35 (IL-35), a member of the interleukin-12 family, has been identified as a novel anti-inflammatory cytokine. In the past ten years, the role of IL-35 in inflammatory and autoimmune diseases has been studied extensively. Serum IL-35 levels, however, have not been studied in LN patients. The aim of the study was to determine serum IL-35 levels in SLE patients with and without nephritis, and their clinical values...
2018: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29574719/il-35-a-hallmark-of-immune-regulation-in-cancer-progression-chronic-infections-and-inflammatory-diseases
#12
REVIEW
Manouchehr Teymouri, Matteo Pirro, Francesca Fallarino, Marco Gargaro, Amirhosein Sahebkar
Cytokine members of the IL-12 family have attracted enormous attention in the last few years, with IL-35 being the one of the most attractive-suppressive cytokine. IL-35 is an important mediator of regulatory T cell function. Regulatory T cells play key roles in restoring immune homeostasis after facing challenges such as infection by specific pathogens. Moreover, a crucial role for regulatory T cell populations has been demonstrated in several physiological processes, including establishment of fetal-maternal tolerance, maintenance of self-tolerance and prevention of autoimmune diseases...
March 25, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29571039/interleukin-35-inhibitory-regulator-in-monocyte-derived-dendritic-cell-maturation-and-activation
#13
Xi Chen, Shengnan Hao, Zhonghua Zhao, Jia Liu, Qianqian Shao, Fang Wang, Dong Sun, Ying He, Wenjuan Gao, Haiting Mao
IL-35, a novel IL-12 family member, is a potent inhibitory cytokine predominantly produced by regulatory T and B lymphocytes that exerts optimal suppression in immune response. However, it remains unclear whether IL-35 plays an inhibitory role on human dendritic cells. In the present study, we focused on the possible immunosuppressive effect of IL-35 on the differentiation, maturation and function of monocyte-derived DCs (MoDCs). Addition of exogenous IL-35 was able to partially suppress MoDCs differentiation in vitro...
March 20, 2018: Cytokine
https://www.readbyqxmd.com/read/29561254/interleukin-35-stimulates-hepatitis-b-virus-transcription-and-replication-by-targeting-transcription-factor-hnf4%C3%AE
#14
Na-Na Tao, Rui Gong, Xiang Chen, Lin He, Fang Ren, Hai-Bo Yu, Juan Chen, Ji-Hua Ren
Hepatitis B virus (HBV) infection is a major health problem worldwide. Interleukin-35 (IL-35) is a definite immunosuppressive cytokine belonging to the IL-12 family. Nevertheless, the role of IL-35 in HBV replication remains elusive. In this study, we found that the level of HBV DNA replicative intermediates detected by qPCR and Southern blotting analysis was significantly increased by rhIL-35 in a dose-dependent manner. Moreover, HBV 3.5 kb mRNA levels were up-regulated by rhIL-35. The HBV core protein level as well as the HBsAg and HBeAg secretion levels were also increased by rhIL-35...
March 21, 2018: Journal of General Virology
https://www.readbyqxmd.com/read/29557072/correlation-between-il-17a-f-il-23-il-35-and-il-12-23-p40-levels-in-peripheral-blood-lymphocyte-cultures-and-disease-activity-in-behcet-s-patients
#15
Cemile Sonmez, Aysegul Atak Yucel, Turan Hilmi Yesil, Hamit Kucuk, Berna Sezgin, Ridvan Mercan, Ahmet Eftal Yucel, Gulderen Yanikkaya Demirel
Behcet's disease is a chronic multisystemic disease with remissions and relapses. Several studies have shown that immune mechanisms play an important role in the development of the disease. In order to assess the association of disease activity with IL-17A/F, IL-23, IL-12/23 (p40) and IL-35 expression, we aimed to investigate production of these cytokines in peripheral blood mononuclear cells (PBMCs) from Behcet's patients and normal controls. Furthermore, we included Systemic Lupus Erythematosus (SLE) as disease control to evaluate the specificity of our data for immunopathogenesis of BD...
March 20, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29554971/oral-escherichia-coli-expressing-il-35-meliorates-experimental-colitis-in-mice
#16
Baoren Zhang, Yi Liu, Xu Lan, Xiaoxi Xu, Xiaoning Zhang, Xiang Li, Yiming Zhao, Guang Li, Caigan Du, Shanzheng Lu, Hao Wang
BACKGROUND: Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD) characterized by chronic inflammation of colon. It is commonly believed that the imbalance of immune system and overwhelming production of cytokines are involved in the pathogenesis of UC. Recent studies demonstrated that interleukin-35 (IL-35), a key player in the regulation of inflammation, has been identified as potential therapeutic target to treat UC. However, conventional intravenous administration is costly and inconvenient...
March 20, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29552287/colon-cancer-induced-interleukin-35-inhibits-beta-catenin-mediated-pro-oncogenic-activity
#17
QiangYue Jiang, Lingyan Ma, RuiChao Li, JianHai Sun
The occurrence and development of colon cancer is closely related to inflammation. Therefore, this study was conducted a current retrospective research to study the effect of IL-35 (interleukin 35), a newly identified anti-infective factor, on colon cancer development. The expression of IL-35 in colon cancer samples and their adjacent normal mucosa by real-time PCR, ELISA (enzyme-linked immunosorbent assay). The effect of IL-35 on patient survival, colon cancer progression, and its effect on Wnt/β-catenine signaling pathway was also assessed...
February 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29549229/expression-of-igf-1-il-27-and-il-35-receptors-in-adjuvant-induced-rheumatoid-arthritis-model
#18
Elham Abdi, Hamid Najafipour, Siyavash Joukar, Shahriar Dabiri, Saeed Esmaeli-Mahani, Elham Abbasloo, Nasrin Houshmandi, Abbas Afsharipour
BACKGROUND: IGF-1 and certain other cytokines have been shown to exert inflammatory/anti-inflammatory roles in chronic joint diseases. OBJECTIVE: To assess the effect of IGF-1, IL-27 and IL-35, their interaction and their receptor expression in a rheumatoid arthritis model. METHODS: Freund's adjuvant-induced chronic joint inflammation was operated on 160 male rats. Animals were divided into histopathology and receptor expression groups, each composed of 10 subgroups including; control, vehicle, IGF-1, IL-27, IL-35, their antagonists, IGF-1+IL-27 antagonist and IGF-1+IL-35 antagonist...
March 2018: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/29528584/effect-of-allergen-specific-immunotherapy-on-serum-levels-of-il-17-and-il-35-in-allergic-rhinitis-patients
#19
Sahar Z Elazab, Waheed F Hessam
Allergic rhinitis (AR) is mediated by many proinflammatory and anti-inflammatory cytokines as interleuhin-17 (IL-17) and interleukin-35 (IL-35) respectively. We assessed the effect of allergen specific immunotherapy (IT) on the serum levels of IL-17 and IL-35 in patients with AR sensitive to house dust mites (HDMs). Twenty patients with AR sensitive to HDMs and ten healthy control subjects were included in the study. Sensitivity to HDMs was diagnosed by positive skin prick test. Patients were treated by cluster IT...
June 2017: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/29524405/dual-expression-of-cxcr4-and-il-35-enhances-the-therapeutic-effects-of-bmscs-on-tnbs-induced-colitis-in-rats-through-expansion-of-tregs-and-suppression-of-th17-cells
#20
Zhen Nan, Heng Fan, Qing Tang, Man Zhang, Meng Xu, Qianyun Chen, Yujin Liu, Yalan Dong, Hui Wu, Shuangjiao Deng
Bone marrow-derived mesenchymal stem cells (BMSCs) hold great promise for the treatment of inflammatory bowel disease owing to their immunosuppressive property and tissue healing potential. The balance between regulatory T cells (Tregs) and T helper (Th)17 cells plays a crucial role in BMSC-mediated immunosuppression. Interleukin (IL)-35 is a newly identified anti-inflammatory cytokine required for the expansion of Tregs and suppression of Th17 cell differentiation. IL-35 can amplify the immunosuppressive property of BMSCs when overexpressed in these cells...
May 23, 2018: Biochemical and Biophysical Research Communications
keyword
keyword
31604
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"