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https://www.readbyqxmd.com/read/28631562/cancer-stem-cell-markers-in-patterning-differentiation-and-in-prognosis-of-oral-squamous-cell-carcinoma
#1
Simple Mohanta, Gangotri Siddappa, Sindhu Govindan Valiyaveedan, Ravindra Dodda Thimmasandra Ramanjanappa, Debashish Das, Ramanan Pandian, Samanta Sekhar Khora, Moni Abraham Kuriakose, Amritha Suresh
Differentiation is a major histological parameter determining tumor aggressiveness and prognosis of the patient; cancer stem cells with their slow dividing and undifferentiated nature might be one of the factors determining the same. This study aims to correlate cancer stem cell markers (CD44 and CD147) with tumor differentiation and evaluate their subsequent effect on prognosis. Immunohistochemical analysis in treatment naïve oral cancer patients (n = 53) indicated that the expression of CD147 was associated with poorly differentiated squamous cell carcinoma and moderately differentiated squamous cell carcinoma (p < 0...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28631213/the-constitutive-protease-release-by-primary-human-acute-myeloid-leukemia-cells
#2
Maria Honnemyr, Øystein Bruserud, Annette K Brenner
INTRODUCTION: Acute myeloid leukemia (AML) cells show constitutive release of matrix metalloproteases and their inhibitors. We now investigated this constitutive release of protease/protease regulators associated with carcinogenesis (ADAM12, uPA, cystatin B), angiogenesis (serpin E1, uPA, CD147), cancer cell migration (uPA, cystatin C), coagulation (ADAM TS13, serpin C1), inflammation (fetuin A, caspase 1, cystatin C), monocytic differentiation (CFD) or regulation of hematopoiesis (neutrophil elastase)...
June 19, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28582638/association-of-cd147-genetic-polymorphisms-with-carotid-atherosclerotic-plaques-in-a-han-chinese-population-with-cerebral-infarction
#3
Tongtian Ni, Min Chen, Kang Yang, Jianwei Shao, Yi Fu, Weijun Zhou
INTRODUCTION: Given the important role of CD147 in the development of atherosclerosis, we speculated that CD147 genetic polymorphisms might influence the formation of carotid atherosclerotic plaques. The study was to investigate the association between CD147 gene polymorphisms and susceptibility to carotid atherosclerotic plaques in individuals with cerebral infarction (CI). METHODS: Eight SNPs in the regulatory and coding regions of the CD147 gene were examined using polymerase chain reaction-ligase detection reaction (PCR-LDR) in DNA samples from 732 Chinese patients with CI, divided into a carotid plaque group (n=475) and a non-carotid plaque group (n=257)...
May 26, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28581487/emmprin-cd147-is-induced-by-c-ebp%C3%AE-and-is-differentially-expressed-in-alk-and-alk-anaplastic-large-cell-lymphoma
#4
Janine Schmidt, Irina Bonzheim, Julia Steinhilber, Ivonne A Montes-Mojarro, Carlos Ortiz-Hidalgo, Wolfram Klapper, Falko Fend, Leticia Quintanilla-Martínez
Anaplastic lymphoma kinase-positive (ALK+) anaplastic large-cell lymphoma (ALCL) is characterized by expression of oncogenic ALK fusion proteins due to the translocation t(2;5)(p23;q35) or variants. Although genotypically a T-cell lymphoma, ALK+ ALCL cells frequently show loss of T-cell-specific surface antigens and expression of monocytic markers. C/EBPβ, a transcription factor constitutively overexpressed in ALK+ ALCL cells, has been shown to play an important role in the activation and differentiation of macrophages and is furthermore capable of transdifferentiating B-cell and T-cell progenitors to macrophages in vitro...
June 5, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28571672/targeting-cd147-for-t-to-nk-lineage-reprogramming-and-tumor-therapy
#5
Jie-Jie Geng, Juan Tang, Xiang-Min Yang, Ruo Chen, Yang Zhang, Kui Zhang, Jin-Lin Miao, Zhi-Nan Chen, Ping Zhu
CD147 is highly expressed on the surface of numerous tumor cells to promote invasion and metastasis. Targeting these cells with CD147-specific antibodies has been validated as an effective approach for lung and liver cancer therapy. In the immune system, CD147 is recognized as a co-stimulatory receptor and impacts the outcome of thymic selection. Using T cell-specific deletion, we showed here that in thymus CD147 is indispensable for the stable αβ T cell lineage commitment: loss of CD147 biases both multipotent DN (double negative) and fully committed DP (double positive) cells into innate NK-like lineages...
May 18, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28569760/strength-of-neisseria-meningitidis-binding-to-endothelial-cells-requires-highly-ordered-cd147-%C3%AE-2-adrenoceptor-clusters-assembled-by-alpha-actinin-4
#6
Nawal Maïssa, Valentina Covarelli, Sébastien Janel, Beatrice Durel, Nandi Simpson, Sandra C Bernard, Liliana Pardo-Lopez, Haniaa Bouzinba-Ségard, Camille Faure, Mark G H Scott, Mathieu Coureuil, Philippe C Morand, Frank Lafont, Xavier Nassif, Stefano Marullo, Sandrine Bourdoulous
Neisseria meningitidis (meningococcus) is an invasive bacterial pathogen that colonizes human vessels, causing thrombotic lesions and meningitis. Establishment of tight interactions with endothelial cells is crucial for meningococci to resist haemodynamic forces. Two endothelial receptors, CD147 and the β2-adrenergic receptor (β2AR), are sequentially engaged by meningococci to adhere and promote signalling events leading to vascular colonization, but their spatiotemporal coordination is unknown. Here we report that CD147 and β2AR form constitutive hetero-oligomeric complexes...
June 1, 2017: Nature Communications
https://www.readbyqxmd.com/read/28560663/cd147-and-glioma-a-meta-analysis
#7
Hui Li, Zhouhuan Xi, Xuejiao Dai, Wenyue Wu, Yanwen Li, Yanting Liu, Hanwen Zhang
Gliomas are the most common primary brain tumors. This meta-analysis aimed to systematically evaluate the relationship between CD147 expression in tissues and the clinicopathological features of patients with glioma. We searched PubMed (1966-2016), EMBASE (1980-2016), Cochrane Library (1996-2016), Web of Science (1945-2016), China National Knowledge Infrastructure (1982-2016), and Wan Fang databases (1988-2016). Quality assessment of the literature was performed using the Newcastle-Ottawa Scale, with Revman 5...
May 30, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28551820/cd147-expression-in-peritoneal-injury
#8
Harald Seeger, Joerg Latus, Daniel Kitterer, M Dominik Alscher, Dagmar Biegger, Jin Chen, Ilka Edenhofer, Rudolf P Wüthrich, Stephan Segerer
BACKGROUND: Peritoneal injury is an important cause of technical failure of long-term peritoneal dialysis (PD). Encapsulating peritoneal sclerosis (EPS) is a severe complication of long-term PD with potentially life threatening consequences. CD147 is a glycoprotein with diverse functions including modulation of extracellular matrix via induction of matrix metalloproteinases, cell adhesion, and regulation of immune reactions. We hypothesized that CD 147 plays a role in the peritoneal cavity...
May 27, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28533482/cd147-functions-as-the-signaling-receptor-for-extracellular-divalent-copper-in-hepatocellular-carcinoma-cells
#9
Pengfei Ding, Xin Zhang, Shujuan Jin, Bo Duan, Pengxiang Chu, Yufei Zhang, Zhi-Nan Chen, Bin Xia, Fei Song
Elevated copper levels in tumor microenvironment are directly correlated to cancer progression in a variety of malignancies. Copper is required in angiogenesis, and promotes the proliferation and metastasis of cancer cells. However, the molecular mechanism of copper in promoting cancer progression remains elusive. Here we report that CD147 serves as a signaling receptor for extracellular Cu2+ in hepatocellular carcinoma (HCC) cells. Cu2+ binds to the extracellular membrane-proximal domain of CD147 and mediates its self-association...
May 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28498412/emmprin-released-as-a-microvesicle-in-epithelioid-sarcoma-interacts-with-fibroblasts
#10
Mikiko Aoki, Kaori Koga, Makoto Hamasaki, Nagayasu Egawa, Kazuki Nabeshima
Emmprin (extracellular matrix metalloproteinase inducer, CD147) is a glycosylated transmembrane protein, consisting of two immunoglobulin domains, that stimulates the production of matrix metalloproteinases (MMPs) by tumor-associated fibroblasts. These effects play important roles in tumor invasion and metastasis. However, the precise mechanisms by which emmprin acts on fibroblasts have not been fully elucidated, especially in sarcoma cells. Previously, we demonstrated that emmprin, expressed in conditioned medium collected from the epithelioid sarcoma cell line (FU-EPS-1), stimulates MMP-2 production via interactions with fibroblasts...
May 8, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28495747/reticulon-3-dependent-er-pm-contact-sites-control-egfr-nonclathrin-endocytosis
#11
Giusi Caldieri, Elisa Barbieri, Gilda Nappo, Andrea Raimondi, Massimo Bonora, Alexia Conte, Lisette G G C Verhoef, Stefano Confalonieri, Maria Grazia Malabarba, Fabrizio Bianchi, Alessandro Cuomo, Tiziana Bonaldi, Emanuele Martini, Davide Mazza, Paolo Pinton, Carlo Tacchetti, Simona Polo, Pier Paolo Di Fiore, Sara Sigismund
The integration of endocytic routes is critical to regulate receptor signaling. A nonclathrin endocytic (NCE) pathway of the epidermal growth factor receptor (EGFR) is activated at high ligand concentrations and targets receptors to degradation, attenuating signaling. Here we performed an unbiased molecular characterization of EGFR-NCE. We identified NCE-specific regulators, including the endoplasmic reticulum (ER)-resident protein reticulon 3 (RTN3) and a specific cargo, CD147. RTN3 was critical for EGFR/CD147-NCE, promoting the creation of plasma membrane (PM)-ER contact sites that were required for the formation and/or maturation of NCE invaginations...
May 12, 2017: Science
https://www.readbyqxmd.com/read/28488587/expression-and-clinical-significance-of-cd147-in-renal-cell-carcinoma-a-meta-analysis
#12
Hui Li, Dongwen Wu, Shupeng Shi, Yadong Xu, Ling Wei, Jing Liu, Yanting Liu
OBJECTIVE: To assess clinical significance of CD147 in renal cell carcinoma. METHODS: Collect case-control studies which focus on CD147's expression in renal cell carcinoma. Trails were retrieved from CBM, CNKI, Wan-fang database, PubMed, Cochrane Library and Embase. According to the inclusion and exclusion criteria, data extraction and quality assessment were done by two researchers independently, and outcomes were pooled with Revman5.3 and STATA14.0. RESULTS: A total of 11 studies were confirmed, among which renal cell carcinoma 887 cases, non-cancer 505cases...
April 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28487989/purification-of-a-polyclonal-antibody-against-cd147-for-elisa-using-antigen%C3%A2-immunoaffinity-chromatography
#13
Shuangshuang Liu, Shasha Li, Yang Zhang, Ye Wang, Yumeng Zhu, Bin Wang, Zhi-Nan Chen
The immunoglobulin superfamily member CD147 is a widely expressed glycoprotein that occurs in both a membrane‑spanning and soluble form. Sandwich ELISA is a powerful tool for analyzing soluble antigens. The aim of the present study was to obtain a highly specific polyclonal antibody against human CD147 that can be used for sandwich ELISA analysis. Expression of recombinant CD147 by a eukaryotic expression system was used to immunize rabbits to obtain antiserum. A highly specific polyclonal antibody that was able to detect soluble CD147 in sandwich ELISA was obtained by antigen‑immunoaffinity chromatography purification...
June 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28445958/repressing-cd147-is-a-novel-therapeutic-strategy-for-malignant-melanoma
#14
REVIEW
Xing Hu, Juan Su, Youyou Zhou, Xiaoyun Xie, Cong Peng, Zhimin Yuan, Xiang Chen
CD147/basigin, a transmembrane protein, is a member of the immunoglobulin super family. Accumulating evidence has revealed the role of CD147 in the development and progression of various cancers, including malignant melanoma (MM). MM is a malignancy of pigment-producing cells that causes the greatest number of skin cancer-related deaths worldwide. CD147 is overexpressed in MM and plays an important role in cell viability, apoptosis, proliferation, invasion, and metastasis, probably by mediating vascular endothelial growth factor (VEGF) production, glycolysis, and multi-drug resistance (MDR)...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28445149/elevated-cd147-expression-is-associated-with-shorter-overall-survival-in-non-small-cell-lung-cancer
#15
Xiaojun Zhang, Tian Tian, Xiaofeng Zhang, Changting Liu, Xiangqun Fang
A number of studies have reported on the prognostic role of CD147 expression in non-small cell lung cancer (NSCLC); however, the results remain controversial. This study aims to investigate the impact of CD147 on the prognosis of NSCLC by means of a meta-analysis. A literature search was performed for relevant studies published before October 29, 2016. The hazard ratios (HRs), odds ratios (ORs), and 95% confidence intervals (CIs) were calculated as effective measures. Sensitivity analysis and publication bias examination were also conducted...
June 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28433697/rab22a-enhances-cd147-recycling-and-is-required-for-lung-cancer-cell-migration-and-invasion
#16
Yang Zhou, Bo Wu, Jiang-Hua Li, Gang Nan, Jian-Li Jiang, Zhi-Nan Chen
Rab22a is a member of the Ras-related small GTPase family, which plays a key role in regulating the recycling of cargo proteins entering cells through clathrin-independent endocytosis (CIE). Rab22a is overexpressed in different cancer types, including liver cancer, malignant melanoma, ovarian cancer and osteosarcoma. However, its oncogenic role remains unknown. In this study, we found that silencing of Rab22a suppressed the migration and invasion of lung cancer cells. Furthermore, Rab22a interacts with CD147, and knockdown of Rab22a blocks CD147 recycling and promotes CD147 degradation...
August 1, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28429960/extracellular-matrix-markers-and-risk-of-myocardial-infarction-the-hunt-study-in-norway
#17
Thor Ueland, Lars E Laugsand, Lars J Vatten, Imre Janszky, Carl Platou, Annika E Michelsen, Jan K Damås, Pål Aukrust, Bjørn O Åsvold
Aims Extracellular matrix remodelling may influence atherosclerotic progression and plaque stability. We hypothesized that evaluation of extracellular matrix markers, with potentially different roles during atherogenesis, could provide information on underlying mechanisms and risk of myocardial infarction (MI) in apparently healthy individuals. Methods We conducted a case-control study nested within the population-based HUNT2 cohort in Norway. A total of 58,761 men and women, free of known cardiovascular disease, were followed for a first MI...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28427166/cd147-overexpression-may-serve-as-a-promising-diagnostic-and-prognostic-marker-for-gastric-cancer-evidence-from-original-research-and-literature
#18
Chenghao Hu, Xiaoxia Dong, Junbo Wu, Feifan Xiao, Jun Shang, Liang Liu, Yuan Yang, Dongmei Luo, Qiuting Li, Qian Song, Jingcheng Yang, Chengdong Zhang, Li Shen, Zhiguo Luo
Gastric cancer (GC) is one of the most common malignancies worldwide. The expression of CD147 protein is associated with GC. However, the clinical role of CD147 in GC has not been investigated extensively. Hence, we focused on studying the association between the expression of CD147 and clinicopathological features of GC patients in this study. Firstly, sixteen publications (1752 cases and 391 controls) and one from our own original research (143 cases) were included in the meta-analysis to obtain a more precise estimation of the diagnostic value of CD147...
May 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28426531/high-fat-feeding-protects-mice-from-ventilator-induced-lung-injury-via-neutrophil-independent-mechanisms
#19
Michael R Wilson, Joanne E Petrie, Michael W Shaw, Cong Hu, Charlotte M Oakley, Samantha J Woods, Brijesh V Patel, Kieran P O'Dea, Masao Takata
OBJECTIVE: Obesity has a complex impact on acute respiratory distress syndrome patients, being associated with increased likelihood of developing the syndrome but reduced likelihood of dying. We propose that such observations are potentially explained by a model in which obesity influences the iatrogenic injury that occurs subsequent to intensive care admission. This study therefore investigated whether fat feeding protected mice from ventilator-induced lung injury. DESIGN: In vivo study...
April 19, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28420895/the-downregulation-of-the-expression-of-cd147-by-tumor-suppressor-reic-dkk-3-and-its-implication-in-human-prostate-cancer-cell-growth-inhibition
#20
Akihiro Mori, Masami Watanabe, Takuya Sadahira, Yasuyuki Kobayashi, Yuichi Ariyoshi, Hideo Ueki, Koichiro Wada, Kazuhiko Ochiai, Shun-Ai Li, Yasutomo Nasu
The cluster of differentiation 147 (CD147), also known as EMMPRIN, is a key molecule that promotes cancer progression. We previously developed an adenoviral vector encoding a tumor suppressor REIC/Dkk-3 gene (Ad-REIC) for cancer gene therapy. The therapeutic effects are based on suppressing the growth of cancer cells, but, the underlying molecular mechanism has not been fully clarified. To elucidate this mechanism, we investigated the effects of Ad-REIC on the expression of CD147 in LNCaP prostate cancer cells...
April 2017: Acta Medica Okayama
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