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https://www.readbyqxmd.com/read/28429960/extracellular-matrix-markers-and-risk-of-myocardial-infarction-the-hunt-study-in-norway
#1
Thor Ueland, Lars E Laugsand, Lars J Vatten, Imre Janszky, Carl Platou, Annika E Michelsen, Jan K Damås, Pål Aukrust, Bjørn O Åsvold
Aims Extracellular matrix remodelling may influence atherosclerotic progression and plaque stability. We hypothesized that evaluation of extracellular matrix markers, with potentially different roles during atherogenesis, could provide information on underlying mechanisms and risk of myocardial infarction (MI) in apparently healthy individuals. Methods We conducted a case-control study nested within the population-based HUNT2 cohort in Norway. A total of 58,761 men and women, free of known cardiovascular disease, were followed for a first MI...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28427166/cd147-overexpression-may-serve-as-a-promising-diagnostic-and-prognostic-marker-for-gastric-cancer-evidence-from-original-research-and-literature
#2
Chenghao Hu, Xiaoxia Dong, Junbo Wu, Feifan Xiao, Jun Shang, Liang Liu, Yuan Yang, Dongmei Luo, Qiuting Li, Qian Song, Jingcheng Yang, Chengdong Zhang, Li Shen, Zhiguo Luo
Gastric cancer (GC) is one of the most common malignancies worldwide. The expression of CD147 protein is associated with GC. However, the clinical role of CD147 in GC has not been investigated extensively. Hence, we focused on studying the association between the expression of CD147 and clinicopathological features of GC patients in this study. Firstly, sixteen publications (1752 cases and 391 controls) and one from our own original research (143 cases) were included in the meta-analysis to obtain a more precise estimation of the diagnostic value of CD147...
February 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28426531/high-fat-feeding-protects-mice-from-ventilator-induced-lung-injury-via-neutrophil-independent-mechanisms
#3
Michael R Wilson, Joanne E Petrie, Michael W Shaw, Cong Hu, Charlotte M Oakley, Samantha J Woods, Brijesh V Patel, Kieran P O'Dea, Masao Takata
OBJECTIVE: Obesity has a complex impact on acute respiratory distress syndrome patients, being associated with increased likelihood of developing the syndrome but reduced likelihood of dying. We propose that such observations are potentially explained by a model in which obesity influences the iatrogenic injury that occurs subsequent to intensive care admission. This study therefore investigated whether fat feeding protected mice from ventilator-induced lung injury. DESIGN: In vivo study...
April 19, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28420895/the-downregulation-of-the-expression-of-cd147-by-tumor-suppressor-reic-dkk-3-and-its-implication-in-human-prostate-cancer-cell-growth-inhibition
#4
Akihiro Mori, Masami Watanabe, Takuya Sadahira, Yasuyuki Kobayashi, Yuichi Ariyoshi, Hideo Ueki, Koichiro Wada, Kazuhiko Ochiai, Shun-Ai Li, Yasutomo Nasu
The cluster of differentiation 147 (CD147), also known as EMMPRIN, is a key molecule that promotes cancer progression. We previously developed an adenoviral vector encoding a tumor suppressor REIC/Dkk-3 gene (Ad-REIC) for cancer gene therapy. The therapeutic effects are based on suppressing the growth of cancer cells, but, the underlying molecular mechanism has not been fully clarified. To elucidate this mechanism, we investigated the effects of Ad-REIC on the expression of CD147 in LNCaP prostate cancer cells...
April 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/28386553/cd147-as-a-novel-prognostic-biomarker-for-hepatocellular-carcinoma-a-meta-analysis
#5
REVIEW
Fei Peng, Hui Li, Qian You, Hongru Li, Dongwen Wu, Chunxiang Jiang, Guangtong Deng, Yan Li, Yuyan Li, Yi Wu
We conducted a meta-analysis to investigate the controversial association of CD147 expression with HCC prognosis and clinicopathological characteristics. Eight studies from PubMed (1966-2016), EMBASE (1980-2016), Cochrane Library (1996-2016), Web of Science (1945-2016), China National Knowledge Infrastructure (1982-2016), and Wanfang databases (1988-2016) were considered. The associations between CD147 expression and clinicopathological parameters and overall survival (OS) or DFS/RFS were reassessed using the meta-analysis for odds ratio (OR) or hazard ratio (HR) and 95% confidence interval (CI)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28381172/the-effects-and-mechanisms-of-slc34a2-on-maintaining-stem-cell-like-phenotypes-in-cd147-breast-cancer-stem-cells
#6
Yonggang Lv, Ting Wang, Jing Fan, Zhenzhen Zhang, Juliang Zhang, Cheng Xu, Yongping Li, Ge Zhao, Chenyang He, Huimin Meng, Hua Yang, Zhen Wang, Jiayun Liu, Jianghao Chen, Ling Wang
The cancer stem cell (CSC) hypothesis has gained significant recognition in describing tumorigenesis. Identification of the factors critical to development of breast cancer stem cells (BCSCs) may provide insight into the improvement of effective therapies against breast cancer. In this study, we aim to investigate the biological function of SLC34A2 in affecting the stem cell-like phenotypes in BCSCs and its underlying mechanisms. We demonstrated that CD147(+) cells from breast cancer tissue samples and cell lines possessed BCSC-like features, including the ability of self-renewal in vitro, differentiation, and tumorigenic potential in vivo...
April 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28358415/expression-levels-of-transcription-factors-c-fos-and-c-jun-and-transmembrane-protein-hab18g-cd147-in-urothelial-carcinoma-of-the-bladder
#7
Muren Huhe, Shuangshuang Liu, Yang Zhang, Zheng Zhang, Zhinan Chen
The aim of the present study was to investigate the prognostic significance of the expression of transcription factors, c-Fos, c-Jun and transmembrane protein CD147, in urothelial carcinoma of the bladder (UCB). The current study investigated the clinical significance of these factors in the development, progression and survival analysis of UCB. Immunohistochemistry was employed to analyze c‑Fos, c‑Jun and CD147 expression in 41 UCB cases and 34 non‑cancerous human bladder tissues. These results were scored in a semi‑quantitative manner based on the intensity and percentage of tumor cells that presented immunoreactivity...
March 30, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28356976/cd147-promotes-the-proliferation-invasiveness-migration-and-angiogenesis-of-human-lung-carcinoma-cells
#8
Shaoxing Yang, Fei Qi, Chuanhao Tang, Hong Wang, Haifeng Qin, Xiaoyan Li, Jianjie Li, Weixia Wang, Changyun Zhao, Hongjun Gao
Cluster of differentiation (CD) 147 is a transmembrane glycoprotein that is highly expressed at the tumor cell surface, which stimulates fibroblasts to produce a large number of matrix metalloproteinases and promotes tumor invasion and metastasis and tumor-induced angiogenesis. The present study investigated the functions and the role of CD147 in the human lung carcinoma A549 cell line. The present study constructed expression and interference [small interfering (si) RNA] lentiviral vectors of CD147, which established stable overexpression and low expression of CD147 in the A549 cell line, named A549-CD147 and A549-siCD147, respectively...
February 2017: Oncology Letters
https://www.readbyqxmd.com/read/28356935/melittin-inhibits-the-invasion-of-mcf-7-cells-by-downregulating-cd147-and-mmp-9-expression
#9
Jianjun Wang, Fengyu Li, Jiang Tan, Xuewei Peng, Lili Sun, Ping Wang, Shengnan Jia, Qingmiao Yu, Hongliang Huo, Hongyan Zhao
Tumor invasion and metastasis are the critical steps in determining the aggressive phenotype of human cancers. Melittin, a major component of bee venom, has been reported to induce apoptosis in several cancer cells. However, the mechanisms of melittin involvement in cancer invasion and metastasis remain unclear. Our previous study indicated that melittin inhibits cyclophilin A (CypA), a ubiquitously distributed peptidylprolyl cis-trans isomerase, in macrophage cells. In the present study, the Transwell assay results showed that melittin may downregulate the invasion level of MCF-7 cells in a dose-dependent manner...
February 2017: Oncology Letters
https://www.readbyqxmd.com/read/28337279/agr2-promotes-the-proliferation-migration-and-regulates-epithelial-mesenchymal-transition-in-salivary-adenoid-cystic-carcinoma
#10
Si-Rui Ma, Liang Mao, Wei-Wei Deng, Yi-Cun Li, Lin-Lin Bu, Guang-Tao Yu, Wen-Feng Zhang, Zhi-Jun Sun
Salivary adenoid cystic carcinoma (AdCC) is a common head and neck cancer with the propensity for local spread and distant metastasis. In our previous study, elevated expression of Anterior gradient 2 (AGR2) was detected in head and neck squamous cell carcinoma (HNSCC), associated with epithelial-mesenchymal transition (EMT) and cancer stemness. However, to date, the expression and function of AGR2 in AdCC has yet to be elucidated. In the present study, human AdCC tissue microarrays including 18 cases of normal salivary gland (NSG), 12 cases of pleomorphic adenoma (PMA) and 72 cases of AdCC were employed for immunohistochemical staining analysis...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28333070/evaluation-of-mct1-mct4-and-cd147-genes-in-peripheral-blood-cells-of-breast-cancer-patients-and-their-potential-use-as-diagnostic-and-prognostic-markers
#11
Maria Cláudia de B Luz, Matheus M Perez, Ligia A Azzalis, Luiz Vinícius de A Sousa, Fernando Adami, Fernando L A Fonseca, Beatriz da C A Alves
BACKGROUND: Patients with breast cancer-the deadliest cancer among women-are at constant risk of developing metastasis. Oxidative stress and hypoxia are common feature of tumor cells that can proliferate even in a resultant metabolic acidosis. Despite the low extracellular pH, intracellular pH of tumor cells remains relatively normal, or even more alkaline due to the action of a membrane protein family known as monocarboxylate transporters (MCTs). The objective of this study was to verify the diagnostic and prognostic value of MCT1, MCT4 and CD147 in tumor and peripheral blood samples of patients with breast cancer undergoing chemotherapic treatment...
March 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28276309/analysis-of-microrna-mrna-interactions-in-stem-cell-enriched-fraction-of-oral-squamous-cell-carcinoma
#12
Vinitha Richard, Rajesh Raju, Aswathy Mary Paul, Reshmi Girijadevi, Thankayyan Retnabai Santhoshkumar, Madhavan Radhakrishna Pillai
This study is an integrated analysis of the transcriptome profile, MicroRNA (miRNA) and their experimentally validatedmRNA targets differentially expressed in the tumorigenic stem-like fraction of oral squamous cell carcinoma (OSCC). We had previously reported the co-existence of multiple drug resistant, tumorigenic fractions termed as side population (SP1, SP2 and MP2) and a non-tumorigenic fraction, main population (MP1) in oral cancer. These fractions displayed self-renewal, regeneration potential and expressed known stemness related cell surface markers despite functional differences...
March 9, 2017: Oncology Research
https://www.readbyqxmd.com/read/28272440/epidermal-cd147-expression-plays-a-key-role-in-il-22-induced-psoriatic-dermatitis
#13
Cong Peng, ShengXi Zhang, Li Lei, Xu Zhang, Xuekun Jia, Zhongling Luo, Xiaoyan Huang, Yanhong Kuang, Weiqi Zeng, Juan Su, Xiang Chen
Psoriasis is a chronic inflammatory skin disease characterized by abnormal keratinocyte proliferation and terminal differentiation. Interleukin-22 (IL-22) and the transcription factor Stat3 play pivotal roles in the pathogenesis of psoriasis. CD147 is a transmembrane glycosylation protein that belongs to the immunoglobulin superfamily. Our previous studies have shown that CD147 is a marker of high keratinocyte proliferation and poor keratinocyte differentiation as well as a psoriasis susceptibility gene. The current study demonstrates that CD147 is highly expressed in psoriatic skin lesions...
March 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28267620/cancer-associated-circulating-large-extracellular-vesicles-in-cholangiocarcinoma-and-hepatocellular-carcinoma
#14
Henrike Julich-Haertel, Sabine K Urban, Marcin Krawczyk, Arnulf Willms, Krzysztof Jankowski, Waldemar Patkowski, Beata Kruk, Maciej Krasnodębski, Joanna Ligocka, Robert Schwab, Ines Richardsen, Sebastian Schaaf, Angelina Klein, Sebastian Gehlert, Hanna Sänger, Markus Casper, Jesus M Banales, Detlef Schuppan, Piotr Milkiewicz, Frank Lammert, Marek Krawczyk, Veronika Lukacs-Kornek, Miroslaw Kornek
BACKGROUND AND AIMS: we previously reported that large extracellular vesicles, specifically AnnexinV(+)EpCAM(+)CD147(+) tumour-associated microparticles (taMPs), facilitate the detection of colorectal carcinoma (CRC), non-small cell lung carcinoma (NSCLC) as well as pancreas carcinoma (PaCa). Here we assess the diagnostic value of taMPs for detection and monitoring of hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA). Specifically, we aim to differentiate liver taMPs from other cancer taMPs, such as CRC and NSCLC...
March 3, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28244853/upregulation-of-cd147-promotes-metastasis-of-cholangiocarcinoma-by-modulating-the-epithelial-to-mesenchymal-transitional-process
#15
Paweena Dana, Ryusho Kariya, Kulthida Vaeteewoottacharn, Kanlayanee Sawanyawisuth, Wunchana Seubwai, Kouki Matsuda, Seiji Okada, Sopit Wongkham
CD147 is a trans-membrane protein that can induce the expression and activity of matrix metalloproteinases (MMP). Expression of CD147 has been shown to potentiate cell migration, invasion, and metastasis of cancer. In this study, the critical role of CD147 in metastasis was elucidated using CD147-overexpressing cholangiocarcinoma (CCA) cells, <em>in vitro</em> and <em>in vivo</em>. The demonstrated molecular mechanism herein, supported that metastasis increased in CD147-overexpressing cells...
December 15, 2016: Oncology Research
https://www.readbyqxmd.com/read/28243336/%C3%AE-3gnt8-promotes-gastric-cancer-invasion-by-regulating-the-glycosylation-of-cd147
#16
Li Shen, Xiaoxia Dong, Meiyun Yu, Zhiguo Luo, Shiliang Wu
β1, 3-N-acetylglucosminyltransferase 8(β3GnT8) synthesizes a unique cabohydrate structure known as polylactosamine, and plays a vital role in progression of various human cancer types. However, its involvement in gastric cancer remains unclear. In this study, we analyzed the expression and clinical significance of β3GnT8 by Western blot in 6 paired fresh gastric cancer tissues, noncancerous tissues and immunohistochemistry on 110 paraffin-embedded slices. β3GnT8 was found to be over-expressed in gastric cancer tissues, which correlated with lymph node metastasis and TNM stage...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28223252/the-origin-and-evolution-of-basigin-bsg-gene-a-comparative-genomic-and-phylogenetic-analysis
#17
Xinyan Zhu, Shenglan Wang, Mingjie Shao, Jie Yan, Fei Liu
Basigin (BSG), also known as extracellular matrix metalloproteinase inducer (EMMPRIN) or cluster of differentiation 147 (CD147), plays various fundamental roles in the intercellular recognition involved in immunologic phenomena, differentiation, and development. In this study, we aimed to compare the similarities and differences of BSG among organisms and explore possible evolutionary relationships based on the comparison result. We used the extensive BLAST tool to search the metazoan genomes, N-glycosylation sites, the transmembrane region and other functional sites...
July 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28198555/involvement-of-cd147-in-alveolar-bone-remodeling-and-soft-tissue-degradation-in-experimental-periodontitis
#18
D Yang, R Liu, L Liu, H Liao, C Wang, Z Cao
BACKGROUND AND OBJECTIVE: The objective of this study was to investigate the possible roles of clusters of differentiation 147 (CD147) in bone resorption and mineralization through the bone markers of bone sialoprotein, osteocalcin, osteopontin and alkaline phosphatase (ALP), trabecular structure of alveolar bone and number of osteoclasts. We also investigated the effects of CD147 on inflammation and collagen breakdown. MATERIAL AND METHODS: Twenty-eight male Wistar rats were randomly divided into four groups of seven animals each: healthy group, periodontitis group, periodontitis + saline group and periodontitis + anti-CD147 groups...
February 15, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/28184176/the-inhibition-role-of-mir-22-in-hepatocellular-carcinoma-cell-migration-and-invasion-via-targeting-cd147
#19
Ling-Juan Luo, Li-Ping Zhang, Chun-Yan Duan, Bei Wang, Na-Na He, Patima Abulimiti, Yan Lin
BACKGROUND: Recently, miR-22 is identified as a tumor-suppressing microRNA in many human cancers. CD147 is a novel cancer-associated biomarker that plays an important role in the invasion and metastasis of malignant tumor. However, the involvement of miR-22 in CD147 regulation and hepatocellular carcinoma (HCC) progression and metastasis has not been investigated. METHODS: We measured miR-22 expression level in 34 paired of HCC and matched normal tissues, HCC cell lines by real-time quantitative RT-PCR...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28148733/dynamic-interaction-and-phospho-proteomics-reveal-lck-as-a-major-signaling-hub-of-cd147-in-t-cells
#20
Verena Supper, Ingrid Hartl, Cyril Boulègue, Anna Ohradanova-Repic, Hannes Stockinger
Numerous publications have addressed CD147 as a tumor marker and regulator of cytoskeleton, cell growth, stress response, or immune cell function; however, the molecular functionality of CD147 remains incompletely understood. Using affinity purification, mass spectrometry, and phosphopeptide enrichment of isotope-labeled peptides, we examined the dynamic of the CD147 microenvironment and the CD147-dependent phosphoproteome in the Jurkat T cell line upon treatment with T cell stimulating agents. We identified novel dynamic interaction partners of CD147 such as CD45, CD47, GNAI2, Lck, RAP1B, and VAT1 and, furthermore, found 76 CD147-dependent phosphorylation sites on 57 proteins...
February 1, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
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