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https://www.readbyqxmd.com/read/28927138/c-jun-mediated-%C3%AE-1-3-n-acetylglucosaminyltransferase-8-expression-a-novel-mechanism-regulating-the-invasion-and-metastasis-of-colorectal-carcinoma-cells
#1
Chunliang Liu, Hao Qiu, Meiyun Yu, Zerong Wang, Yaqin Yuan, Zhi Jiang, Xuejun Shao, Dong Hua, Min Liu, Shiliang Wu
β-1,3-N-Acetylglucosaminyltransferase 8 (β3GnT8) is a key enzyme that catalyzes the formation of polylactosamine glycan structures by transferring GlcNAc to tetra-antennary β1-6-branched N-glycans, and it has been reported to participate in tumor invasion and metastasis by regulating the expression of matrix metalloproteinases (MMPs), cluster of differentiation 147 (CD147) and polylactosamine. By contrast, the role of transcription factor c-Jun in cell cycle progression has been well established. c-Jun has an important role in tumor cell invasion and metastasis...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28927069/overexpression-of-reic-dkk-3-suppresses-the-expression-of-cd147-and-inhibits-the-proliferation-of-human-bladder-cancer-cells
#2
Yuhei Horikawa, Masami Watanabe, Takuya Sadahira, Yuichi Ariyoshi, Yasuyuki Kobayashi, Motoo Araki, Koichiro Wada, Kazuhiko Ochiai, Shun-Ai Li, Yasutomo Nasu
Our group previously developed an adenoviral vector encoding the REIC/Dkk-3 gene (Ad-REIC), a tumor suppressor, for cancer gene therapy. The Ad-REIC agent induces apoptosis and inhibits invasion in a number of cancer cell lines; however, the molecular mechanisms underlying its effects remain unclear. Cluster of differentiation 147 (CD147), also known as extracellular matrix metalloproteinase inducer (EMMPRIN), is a key molecule that promotes cancer proliferation and invasion. In order to elucidate the therapeutic mechanism of Ad-REIC, its effect on the expression of CD147 in human bladder cancer KK47 cells was investigated...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28910304/comparative-proteomic-investigation-of-metastatic-and-non-metastatic-osteosarcoma-cells-of-human-and-canine-origin
#3
Jahnabi Roy, Kathryn L Wycislo, Holly Pondenis, Timothy M Fan, Aditi Das
Osteosarcoma is the most common bone cancer in dogs and people. In order to improve clinical outcomes, it is necessary to identify proteins that are differentially expressed by metastatic cells. Membrane bound proteins are responsible for multiple pro-metastatic functions. Therefore characterizing the differential expression of membranous proteins between metastatic and non-metastatic clonal variants will allow the discovery of druggable targets and consequently improve treatment methodology. The objective of this investigation was to systemically identify the membrane-associated proteomics of metastatic and non-metastatic variants of human and canine origin...
2017: PloS One
https://www.readbyqxmd.com/read/28892257/candidate-gene-molecular-markers-as-tools-for-analyzing-genetic-susceptibility-to-morbillivirus-infection-in-stranded-cetaceans
#4
Karla Stejskalova, Zuzana Bayerova, Jan Futas, Kristyna Hrazdilova, Marie Klumplerova, Jan Oppelt, Petra Splichalova, Giovanni Di Guardo, Sandro Mazzariol, Cristina Esmeralda Di Francesco, Gabriella Di Francesco, Giuliana Terracciano, Romulus-Marian Paiu, Teodor Dan Ursache, David Modry, Petr Horin
Morbilliviruses, such as Cetacean morbillivirus (CeMV) or Phocine distemper virus (PDV), represent a growing threat for marine mammals on both hemispheres. Since free-ranging animal populations strongly rely on natural resistance mechanisms, innate immunity related genes and virus cell entry receptor genes may represent key factors involved in susceptibility to CeMV in Cetaceans. Using the next generation sequencing technology, we have sequenced eleven candidate genes in two model species, Stenella coeruleoalba and Phocoena phocoena...
September 11, 2017: HLA
https://www.readbyqxmd.com/read/28881651/expression-and-clinical-significance-of-cd147-in-renal-cell-carcinoma-a-meta-analysis
#5
Hui Li, Dongwen Wu, Shupeng Shi, Yadong Xu, Ling Wei, Jing Liu, Yanting Liu
OBJECTIVE: To assess clinical significance of CD147 in renal cell carcinoma. METHODS: Collect case-control studies which focus on CD147's expression in renal cell carcinoma. Trails were retrieved from CBM, CNKI, Wan-fang database, PubMed, Cochrane Library and Embase. According to the inclusion and exclusion criteria, data extraction and quality assessment were done by two researchers independently, and outcomes were pooled with Revman5.3 and STATA14.0. RESULTS: A total of 11 studies were confirmed, among which renal cell carcinoma 887 cases, non-cancer 505cases...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28881637/cd147-functions-as-the-signaling-receptor-for-extracellular-divalent-copper-in-hepatocellular-carcinoma-cells
#6
Pengfei Ding, Xin Zhang, Shujuan Jin, Bo Duan, Pengxiang Chu, Yufei Zhang, Zhi-Nan Chen, Bin Xia, Fei Song
Elevated copper levels in tumor microenvironment are directly correlated to cancer progression in a variety of malignancies. Copper is required in angiogenesis, and promotes the proliferation and metastasis of cancer cells. However, the molecular mechanism of copper in promoting cancer progression remains elusive. Here we report that CD147 serves as a signaling receptor for extracellular Cu(2+) in hepatocellular carcinoma (HCC) cells. Cu(2+) binds to the extracellular membrane-proximal domain of CD147 and mediates its self-association...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28874966/characterization-of-acetate-transport-in-colorectal-cancer-cells-and-potential-therapeutic-implications
#7
Suellen Ferro, João Azevedo-Silva, Margarida Casal, Manuela Côrte-Real, Fatima Baltazar, Ana Preto
Acetate, together with other short chain fatty acids has been implicated in colorectal cancer (CRC) prevention/therapy. Acetate was shown to induce apoptosis in CRC cells. The precise mechanism underlying acetate transport across CRC cells membrane, that may be implicated in its selectivity towards CRC cells, is not fully understood and was addressed here. We also assessed the effect of acetate in CRC glycolytic metabolism and explored its use in combination with the glycolytic inhibitor 3-bromopyruvate (3BP)...
October 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/28832687/nuclear-envelope-distributed-cd147-interacts-with-and-inhibits-the-transcriptional-function-of-ring1-and-promotes-melanoma-cell-motility
#8
Junchen Chen, Cong Peng, Li Lei, Jianglin Zhang, Weiqi Zeng, Xiang Chen
Melanoma accounts for nearly 80% of all deaths associated with skin cancer.CD147 plays a very important role in melanoma progression and the expression level may correlate with tumor malignancy. RING1 can bind DNA and act as a transcriptional repressor, play an important role in the aggressive phenotype in melanoma. The interactions between CD147 and RING1 were identified with a yeast two-hybrid and RING1 interacted with CD147 through the transmembrane domain. RING1 inhibits CD147's capability promoting melanoma cell migration...
2017: PloS One
https://www.readbyqxmd.com/read/28828658/multi-surface-antigen-staining-of-larger-extracellular-vesicles
#9
Veronika Lukacs-Kornek, Henrike Julich-Haertel, Sabine Katharina Urban, Miroslaw Kornek
Larger extracellular vesicles, microparticles (MPs) or microvesicles (MVs), especially their acquisition and characterization by flow cytometry (FACS), is increasingly in focus of clinical/translational research efforts. Several laboratories have shown that MPs/MVs might be suitable for the diagnosis and predicting prognosis in various diseases including cancer. However, FACS staining of larger extracellular vesicles (EVs) can be difficult and results potentially in false positive and inconsistent data interpretation...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28819176/use-of-biocompatible-sorafenib-gold-nanoconjugates-for-reversal-of-drug-resistance-in-human-hepatoblatoma-cells
#10
Sandeep Kumar Vishwakarma, Priyanka Sharmila, Avinash Bardia, Lakkireddy Chandrakala, N Raju, G Sravani, B V S Sastry, Md Aejaz Habeeb, Aleem Ahmed Khan, Marshal Dhayal
The present study identifies the potential of highly biocompatible SF-GNP nano-conjugate to enhance the chemotherapeutic response to combat drug resistance in cancer cells. We developed a stable colloidal suspension of sorafenib-gold nanoconjugate (SF-GNP) of <10 nm size in aqueous medium for reverting the cancer drug resistance in SF-resistant HepG2 cells in a 3D ex-vivo model system. In-vivo biocompatibility assay of SF-GNPs showed absence of systemic toxicological effects including hematological, biochemical and histological parameters...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28762325/activation-of-vimentin-is-critical-to-promote-a-metastatic-potential-of-cholangiocarcinoma-cells
#11
Waraporn Saentaweesuk, Norie Araki, Kulthida Vaeteewoottacharn, Atit Silsirivanit, Wunchana Seubwai, Chutima Talabnin, Kanha Muisuk, Banchob Sripa, Sopit Wongkham, Seiji Okada, Chaisiri Wongkham
Cholangiocarcinoma (CCA) is a highly metastatic tumor, of which the majority of the patients have short survival due tono effective treatment. Hence, a better understanding regarding CCA metastasis may provide an opportunity to improve the strategies for treatment. A comparison study between the highly metastatic cells and their parental cells is an approach to uncover the molecular mechanisms underlying the metastatic process. In the present study, a lung metastatic CCA cell line, KKU-214L5 was established by the in vivo selection of the tail-vein injected mouse model...
July 25, 2017: Oncology Research
https://www.readbyqxmd.com/read/28747577/cd147-as-a-novel-biomarker-for-predicting-the-prognosis-and-clinicopathological-features-of-bladder-cancer-a-meta-analysis
#12
Hongru Li, Yadong Xu, Hui Li
Objective To assess the prognostic and clinicopathological characteristics of CD147 in human bladder cancer.Methods Studies on CD147 expression in bladder cancer were retrieved from PubMed, EMBASE, the Cochrane Library, Web of Science, China National Knowledge Infrastructure, and the WanFang databases. Outcomes were pooled with meta-analyzing softwares RevMan 5.3 and STATA 14.0.Results Twenty-four studies with 25 datasets demonstrated that CD147 expression was higher in bladder cancer than in non-cancer tissues (OR=43...
July 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28733558/glut1-expression-in-pediatric-adrenocortical-tumors-a-promising-candidate-to-predict-clinical-behavior
#13
Céline Pinheiro, Sara Granja, Adhemar Longatto-Filho, André M Faria, Maria C B V Fragoso, Silvana M Lovisolo, Murilo Bonatelli, Ricardo F A Costa, Antonio M Lerário, Madson Q Almeida, Fátima Baltazar, Maria C N Zerbini
BACKGROUND: Discrimination between benign and malignant tumors is a challenging process in pediatric adrenocortical tumors. New insights in the metabolic profile of pediatric adrenocortical tumors may contribute to this distinction, predict prognosis, as well as identify new molecular targets for therapy. The aim of this work is to characterize the expression of the metabolism-related proteins MCT1, MCT2, MCT4, CD147, CD44, GLUT1 and CAIX in a series of pediatric adrenocortical tumors...
July 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28729360/potential-role-of-cyclophilin-a-in-regulating-cytokine-secretion
#14
REVIEW
Farman Ullah Dawar, Yang Xiong, Muhammad Nasir Khan Khattak, Jun Li, Li Lin, Jie Mei
Cyclophilin A (CypA), a peptidylprolyl cis-trans isomerase, is a ubiquitous and multifunctional protein. In addition to its role as a host-cell receptor for cyclosporine A, CypA has diverse functions in inflammatory conditions and diseases. CypA secreted in response to inflammatory stimuli binds to the cell surface via its receptor CD147 and induces secretion of various inflammatory cytokines. However, silencing and inhibition of either CypA or CD147 inhibits inflammatory cytokine expression and inflammation...
July 20, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28721406/chemical-proteomics-reveal-cd147-as-a-functional-target-of-pseudolaric-acid-b-in-human-cancer-cells
#15
Yiqing Zhou, Zhengao Di, Xiaoming Li, Yuanhong Shan, Weichao Li, Haibing Zhang, Youli Xiao
CD147 is a glycosylated transmembrane protein highly expressed on the surface of various tumor cells which plays vital roles in tumor invasion, progression and metastasis. We report the discovery of the natural product pseudolaric acid B (PAB) directly targeting CD147 by chemical proteomics utilizing a PAB-derived photoaffinity probe which could serve as a novel type of anticancer reagent.
July 19, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28703811/cytoplasmic-fragment-of-cd147-generated-by-regulated-intramembrane-proteolysis-contributes-to-hcc-by-promoting-autophagy
#16
Bo Wu, Jian Cui, Xiang-Min Yang, Zhen-Yu Liu, Fei Song, Ling Li, Jian-Li Jiang, Zhi-Nan Chen
Hepatocellular carcinoma (HCC) is one of the most lethal and prevalent cancers worldwide. CD147 (EMMPRIN or basigin) is a leading gene relating to hepatocarcinogenesis and metastasis, and is detected in transmembrane, exosome or circulating forms in HCC patients. The endosome recycling of CD147 further enhances the function of this oncoprotein from a dynamic perspective. However, previous studies about CD147 mainly focused on one separate form, and little attention has been paid to how the different forms of tumor-derived CD147 changes...
July 13, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28700599/the-prognostic-and-clinicopathologic-characteristics-of-cd147-and-esophagus-cancer-a-meta-analysis
#17
Hui Li, Chunxiang Jiang, Dongwen Wu, Shupeng Shi, Mengting Liao, Jing Wang, Yanwen Li, Zihao Xu
OBJECTIVE: The prognostic significance of CD147 expression in esophageal cancer patients remains controversial. Using a meta-analysis, we investigated the prognostic and clinicopathologic characteristics of CD147 in esophageal cancer. METHODS: A comprehensive literature search of the PubMed (1966-2016), EMBASE (1980-2016), Cochrane Library (1996-2016), Web of Science (1945-2016), China National Knowledge Infrastructure (1982-2016), and Wanfang databases (1988-2016) was performed to identify studies of all esophageal cancer subtypes...
2017: PloS One
https://www.readbyqxmd.com/read/28699528/targeting-cd147-is-a-novel-strategy-for-antitumor-therapy
#18
ChengXiang Lian, Yeye Guo, Jianglin Zhang, Xiang Chen, Cong Peng
CD147 is a membrane protein belonging to immunoglobulin superfamily and expressed in the cell membrane, which is also named with an extracellular matrix metalloproteinase inducer (EMMPRIN) because this molecule induces adjacent fibroblasts or tumor cells to produce MMPs, facilitating tumor cells migration and invasion. Accumulating evidences have shown that CD147 is over-expressed in various tumors, including melanoma, liver cancer, and lung cancer, and orchestrates tumor cell proliferation, apoptosis, invasion and metastasis, multidrug resistance and glycolysis through critical molecules such as MMPs, MCTs, Caveolin-1, and VEGF...
July 10, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28684116/cd147-induced-cell-proliferation-is-associated-with-smad4-signal-inhibition
#19
Hui Qin, Azhar Rasul, Xin Li, Muqaddas Masood, Guang Yang, Na Wang, Wei Wei, Xi He, Nobumoto Watanabe, Jiang Li, Xiaomeng Li
CD147 is a multifunctional trans-membrane glycoprotein, which is highly expressed in many cancers. However, the mechanism by which CD147 modulates cell proliferation is not fully understood. The aim of this study is to investigate the role of CD147 in cell proliferation associated with the TGF-β/Smad4 signaling pathway. Here, we used cell viability and clone formation assays in LNCaP prostate cancer cells to demonstrate that CD147 promotes cell proliferation. The luciferase assay and western blotting show that silencing CD147 using shRNA enhances transcription and expression of p21(WAF1)...
July 3, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28683106/cytomegalovirus-infection-in-hiv-infected-and-uninfected-individuals-is-characterized-by-circulating-regulatory-t-cells-of-unconstrained-antigenic-specificity
#20
Adriana Tovar-Salazar, Adriana Weinberg
Cytomegalovirus (CMV) infection is associated with immune-suppression in immune-compromised hosts and old adults. We previously showed that ex vivo CMV restimulation of peripheral blood mononuclear cells (PBMC) of CMV-seropositive volunteers expanded CD4+CD27-CD28- regulatory T cells (Tregs). Here we evaluate the phenotype and function of circulating CD4+CD27-CD28- T cells of CMV-seropositive adults. Compared with CMV-seronegative, CMV-seropositive adults had 10-fold higher CD4+CD27-CD28-% T cells in PBMC. Circulating CD4+CD27-CD28- T cells from both CMV-seropositive and seronegative donors expressed higher levels of TGFβ, granzyme B, CD39, CD147 and IL-35, and lower levels of CD127, compared with their parent circulating CD4+ T cells...
2017: PloS One
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