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https://www.readbyqxmd.com/read/29651619/silk-fibroin-based-woven-endovascular-prosthesis-with-heparin-surface-modification
#1
Zekun Liu, Gang Li, Zhaozhu Zheng, Yuling Li, Yifan Han, David L Kaplan, Xiaoqin Wang
A novel seamless silk fibroin-based endovascular prosthesis (SFEPs) with bifurcated woven structure and anticoagulant function for the improvement of patency is described. The SFEPs were prepared from silk fibroin (SF) and polyester filaments using an installed weaving machine. The production processing parameters were optimized using orthogonal design methods. The inner surface of SFEPs was modified with polyethylenimine (PEI) and EDC/NHS-activated low-molecular-weight heparin (LMWH) to enhance anticoagulant function...
April 12, 2018: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29648661/anticoagulation-therapy-in-patients-with-non-valvular-atrial-fibrillation-hospitalized-in-the-department-of-medicine-in-the-noacs-era
#2
Alaa Atamna, Mohamad Suki, Hadeel Kena'any, Avishay Elis
Background: The treatment of atrial fibrillation (AF) includes anticoagulation therapy (AC) to prevent systemic emboli. Until recently, warfarin was the main anticoagulation agent, while in recent years the new oral anticoagulants (NOACs) are increasingly being used. The aim of our study was to characterize the AC treatment policy of AF patients at the department of medicine in the NOACs era. Methods: An observational study of consecutive hospitalized patients with non-valvular AF for a period of 3 months in Beilinson hospital (January - March 2017)...
April 10, 2018: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29629262/thrombolysis-followed-by-apixaban-for-massive-pulmonary-embolism-and-free-floating-thrombus-in-right-ventricle-in-a-patient-with-breast-cancer
#3
Sergio Fasullo, Nicola Morabito, Sergio Cannizzaro, Gioacchino Cosenza, Vito Pinto, Filippo Ganci, Sebastiano Scalzo, Stefania Davi, Giorgio Maringhini
Free-floating thrombus in the right ventricle, associated with a massive acute pulmonary embolism (PE), is a rare phenomenon. PE is an important clinical entity with considerable mortality despite advances in diagnosis and treatment. The prognosis of PE depends on right ventricular dysfunction, myocardial injury markers, and early treatment. In this report, we present the case of a 71-year-old woman with a history of breast cancer admitted to intensive care unit for PE complicated by syncope. Although our case may seem complex because it is not represented in the guidelines, the result was satisfactory and showed how treatment with new anticoagulants (in this case apixaban) after massive thrombolysis of PE could be considered and included in the new guidelines...
January 2018: Journal of Cardiovascular Echography
https://www.readbyqxmd.com/read/29626281/hospital-length-of-stay-in-patients-initiated-on-direct-oral-anticoagulants-versus-warfarin-for-venous-thromboembolism-a-real-world-single-center-study
#4
Hisham Badreldin
This study was conducted to describe the real-world hospital length of stay in patients treated with all of the U.S. Food and Drug Administration approved direct oral anticoagulants (DOACs) versus warfarin for new-onset venous thromboembolism (VTE) at a large, tertiary, academic medical center. A retrospective cohort analysis of all adult patients diagnosed with acute onset VTE was conducted. Of the 441 patients included, 261 (57%) patients received DOACs versus 180 (41%) patients received warfarin. In the DOAC group, a total of 92 (35%) patients received rivaroxaban, followed by 83 (32%) patients received apixaban, 50 (19%) patients received dabigatran, and 36 (14%) patients received edoxaban...
April 6, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29626048/dabigatran-persistence-and-adherence-in-new-zealand-a-nationwide-retrospective-observational-study
#5
Paul Harper, Daryl Pollock, Matt Stephens
OBJECTIVE: To determine the effect of age and gender on persistence and adherence in patients taking dabigatran for atrial fibrillation. DESIGN: A retrospective observational study over 4 years using refill prescription data from the National Pharmaceutical Database. SETTING: All patients in New Zealand who received dabigatran from July 2011 to September 2015. POPULATION: 43 339 people filled at least one prescription of dabigatran...
April 5, 2018: BMJ Open
https://www.readbyqxmd.com/read/29624137/multi-disciplinary-decision-making-in-general-practice
#6
Ann Kirby, Aileen Murphy, Colin Bradley
Purpose Internationally, healthcare systems are moving towards delivering care in an integrated manner which advocates a multi-disciplinary approach to decision making. Such an approach is formally encouraged in the management of Atrial Fibrillation patients through the European Society of Cardiology guidelines. Since the emergence of new oral anticoagulants switching between oral anticoagulants (OACs) has become prevalent. This case study considers the role of multi-disciplinary decision making, given the complex nature of the agents...
April 9, 2018: Journal of Health Organization and Management
https://www.readbyqxmd.com/read/29622911/submitral-left-ventricular-aneurysm-associated-with-thrombus
#7
Abdusamed Adem Abdusamed, Hailu Abera Mulatu, Reinaldo Nunez Martinez
Background: Submitral left ventricular aneurysm is a rarely reported cardiac abnormality that is encountered commonly among blacks. So far, only one case has been reported from Ethiopia and East Africa.Our aim is to report an interesting and rare case that we encountered at St. Paul's Hospital Millennium Medical College. Methods: In April 2017, a 25-year-old patient havingsubmitral left ventricular aneurysm with New York Heart Association (NYHA) class IV heart failure and mild left ventricular systolic dysfunctionreceived medical treatment at our institution...
January 2018: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29622761/simultaneous-pancreas-kidney-transplantation-in-a-patient-with-heparin-induced-thrombocytopenia-on-dabigatran-therapy
#8
Agnieszka Jóźwik, Wojciech Lisik, Jarosław Czerwiński, Maciej Kosieradzki
BACKGROUND New oral anticoagulants like direct thrombin inhibitors are an attractive alternative to vitamin K antagonists as anticoagulation therapy and can be used in heparin-induced thrombocytopenia. They are convenient in low-risk surgery, as there is no need for bridging with heparins. Patients who need urgent major surgery are at similar risk as on warfarin therapy, which, however, is much higher than in elective procedures. Due to their elimination profiles, these drugs are generally contraindicated in patients with severe renal insufficiency...
April 6, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29622591/safety-and-efficacy-of-novel-oral-anticoagulants-versus-warfarin-in-medicare-beneficiaries-with-atrial-fibrillation-and-valvular-heart-disease
#9
Alexandros Briasoulis, Chakradhari Inampudi, Emmanuel Akintoye, Paulino Alvarez, Sidakpal Panaich, Mary Vaughan-Sarrazin
BACKGROUND: We examined a large community-based sample of patients with atrial fibrillation (AF) and valvular heart disease (VHD) (excluding prosthetic valves) with a goal to compare outcomes among patients with AF, with and without VHD, taking warfarin, dabigatran, and rivaroxaban. METHODS AND RESULTS: We identified Medicare beneficiaries enrolled in Medicare Part D benefit plan from 2011 to 2013 with newly diagnosed AF (18 137 patients with VHD [dabigatran, 1979; rivaroxaban, 2027; warfarin, 14 131] and 85 596 patients without VHD [dabigatran, 13 522; rivaroxaban, 14 257; warfarin, 57 817])...
April 5, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29614970/a-novel-citrate-based-protocol-versus-heparin-anticoagulation-for-sustained-low-efficiency-dialysis-in-the-icu-safety-efficacy-and-cost
#10
Ming Wen, Claudius Küchle, Dominik Steubl, Robin Satanovskji, Uwe Heemann, Yana Suttmann, Susanne Angermann, Stephan Kemmner, Lisa Rehbehn, Monika Huber, Christine Hauser, Christoph Schmaderer, Anna-Lena Reichelt, Bernhard Haller, Lutz Renders
BACKGROUND: The high cost, complexity of the available protocols, and metabolic complications are the major barriers that impede the clinical utilization of regional citrate anticoagulation (RCA) for sustained low efficiency dialysis (SLED) in critically ill patients. By comparing a novel protocol for SLED using 30% citrate solution with common protocol using unfractionated heparin, this study aimed to provide new insights for clinical applications of RCA. METHODS: In this retrospective study, a total of 282 critically ill patients who underwent SLED with citrate and/or heparin anticoagulation in six adult ICUs were enrolled...
April 3, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29614814/the-role-of-single-molecule-force-spectroscopy-in-unraveling-typical-and-autoimmune-heparin-induced-thrombocytopenia
#11
REVIEW
Van-Chien Bui, Thi-Huong Nguyen
For the last two decades, heparins have been widely used as anticoagulants. Besides numerous advantages, up to 5% patients with heparin administration suffer from a major adverse drug effect known as heparin-induced thrombocytopenia (HIT). This typical HIT can result in deep vein thrombosis, pulmonary embolism, occlusion of a limb artery, acute myocardial infarct, stroke, and a systemic reaction or skin necrosis. The basis of HIT may lead to clinical insights. Recent studies using single-molecule force spectroscopy (SMFS)-based atomic force microscopy revealed detailed binding mechanisms of the interactions between platelet factor 4 (PF4) and heparins of different lengths in typical HIT...
April 2, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29611427/impact-of-known-or-new-onset-atrial-fibrillation-on-2-year-cardiovascular-event-rate-in-patients-with-acute-coronary-syndromes-results-from-the-prospective-epicor-registry
#12
Uwe Zeymer, Lieven Annemans, Nicolas Danchin, Stuart Pocock, Simon Newsome, Frans Van de Werf, Jesús Medina, Héctor Bueno
BACKGROUND: Atrial fibrillation (AF) is associated with increased morbidity in acute coronary syndrome patients, but impact on outcomes beyond 1 year is unclear. METHODS: This was a post-hoc analysis from the long-tErm follow-uP of antithrombotic management patterns In acute CORonary syndrome patients (EPICOR) registry (NCT01171404), a prospective, observational study conducted in Europe and Latin America, which enrolled acute coronary syndrome survivors at discharge...
April 1, 2018: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/29611164/thermic-sealing-in-femoral-catheterisation-first-experience-with-the-secure-device
#13
Michael Sacherer, Ewald Kolesnik, Friederike von Lewinski, Nicolas Verheyen, Karin Brandner, Markus Wallner, Deborah M Eaton, Olev Luha, Robert Zweiker, Dirk von Lewinski
BACKGROUND: Devices currently used to achieve hemostasis of the femoral artery following percutaneous cardiac catheterization are associated with vascular complications and remnants of artificial materials are retained at the puncture site. The SECURE arterial closure device induces hemostasis by utilizing thermal energy, which causes collagen shrinking and swelling. In comparison to established devices, it has the advantage of leaving no foreign material in the body following closing...
April 3, 2018: Cardiology Journal
https://www.readbyqxmd.com/read/29610163/recanalization-of-occluded-central-veins-in-a-parenteral-nutrition-dependent-child-with-no-access
#14
Patrick M Sullivan, Russell Merritt, Juan Carlos Pelayo, Frank F Ing
Central venous thromboses are common and pose challenges in the care of chronically ill pediatric patients. Among patients with intestinal failure (most commonly because of short bowel syndrome) who depend on parenteral nutrition, progressive loss of central venous access sites is a potentially fatal complication. We present the case of a 5-year-old girl with parenteral nutrition-dependent short bowel syndrome and no remaining standard central venous access sites despite medical anticoagulation, in whom angioplasty and stent implantations were used to reconstruct chronically occluded central veins...
April 2018: Pediatrics
https://www.readbyqxmd.com/read/29609697/2018-new-drug-update
#15
Daniel A Hussar, Laura A Finn
Five new drugs marketed within the last year, which are used for medical problems often experienced by the elderly, have been selected for consideration in this review. The uses and most important properties of these agents are discussed, and a rating for each new drug is determined using the New Drug Comparison Rating system developed by the author (DAH). Advantages, disadvantages, and other important information regarding each new drug are identified and used as the basis for determining the rating. The drugs include an anticoagulant, an antiparkinson agent, an agent for tardive dyskinesia, an agent for psoriasis, and an agent for constipation...
April 1, 2018: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/29602837/trends-in-initiation-of-direct-oral-anticoagulant-therapies-for-atrial-fibrillation-in-a-national-population-based-cross-sectional-study-in-the-french-health-insurance-databases
#16
Laetitia Huiart, Cyril Ferdynus, Christel Renoux, Amélie Beaugrand, Sophie Lafarge, Léa Bruneau, Samy Suissa, Olivier Maillard, Xavier Ranouil
OBJECTIVE: Unlike several other national health agencies, French health authorities recommended that the newer direct oral anticoagulant (DOAC) agents only be prescribed as second choice for the treatment of newly diagnosed non-valvular atrial fibrillation (NVAF), with vitamin K antagonists (VKA) remaining the first choice. We investigated the patterns of use of DOACs versus VKA in the treatment of NVAF in France over the first 5 years of DOAC availability. We also identified the changes in patient characteristics of those who initiated DOAC treatment over this time period...
March 30, 2018: BMJ Open
https://www.readbyqxmd.com/read/29599284/correlation-of-non-vitamin-k-antagonist-oral-anticoagulant-exposure-and-cerebral-microbleeds-in-chinese-patients-with-atrial-fibrillation
#17
Yannie Soo, Jill Abrigo, Kam Tat Leung, Wenyan Liu, Bonnie Lam, Suk Fung Tsang, Vincent Ip, Karen Ma, Bonaventure Ip, Sze Ho Ma, Florence Fan, Winnie Chu, Lawrence Wong, Vincent Mok, Thomas W Leung
BACKGROUND AND PURPOSE: Cerebral microbleeds (CMBs) are radiological markers which predict future intracerebral haemorrhage. Researchers are exploring how CMBs can guide anticoagulation decisions in atrial fibrillation (AF). The purpose of this study is to evaluate the correlation of non-vitamin K antagonist oral anticoagulants (NOAC) exposure and prevalence of CMBs in Chinese patients with AF. METHODS: We prospectively recruited Chinese patients with AF on NOAC therapy of ≥30 days for 3T MRI brain for evaluation of CMBs and white matter hyperintensities...
March 29, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29599096/antithrombotic-therapy-trends-in-non-valvular-atrial-fibrillation-patients-undergoing-percutaneous-coronary-stent-implantation-results-from-a-survey-among-fellows-at-the-japanese-college-of-cardiology
#18
Daisuke Fukamachi, Atsushi Hirayama, Katsumi Miyauchi, Satoshi Yasuda, Hisao Ogawa, Hiroshi Ito, Hiroyuki Daida
BACKGROUND: Antithrombotic therapy with oral anticoagulants (OAC) in patients with atrial fibrillation (AF) after stent implantation, where dual antiplatelet therapy (DAPT) is also recommended, is not established. Antithrombotic therapies prescribed vary widely among cardiologists and may change year by year, according to the accumulation of new evidence. METHODS: A questionnaire-based survey concerning the antithrombotic therapy prescribed for OAC-treated AF patients who underwent stent implantation was conducted from 2014 to 2016...
March 26, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29595110/coumarin-compounds-in-medicinal-chemistry-some-important-examples-from-the-last-year
#19
Arthur Eugen Kummerle, Felipe Vitorio, Daiana Portella Franco, Thiago Moreira Pereira
Coumarins are natural products characterized as 1,2 benzopirones widely distributed in plants, as well as, in many species of fungi and bacteria. Nowadays, many synthetic procedures allow the discovery of coumarins with expanded chemical space. The ability to exert noncovalent interactions with many enzymes and receptors in live organisms lead the coumarins to exhibit a wide range of biological activities and applications. Then, this manuscript provides an overview of the use of coumarins compounds in Medicinal Chemistry in treating many diseases...
March 28, 2018: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29590385/the-new-2016-european-society-of-cardiology-european-association-for-cardio-thoracic-surgery-guidelines-enough-guidance-enough-evidence
#20
Manuel Castellá
For the first time, the European Society of Cardiology and the European Association for Cardio-Thoracic Surgery have joined forces to develop consensus guidelines for the management of atrial fibrillation (AF). One of the main issues is the integrated care of patients with AF, with emphasis on multidisciplinary teams of general physicians, cardiologists, stroke specialists and surgeons, together with the patient's involvement for better management of AF. These guidelines also help in the detection of risk factors and concomitant cardiovascular diseases, stroke prevention therapies, including anticoagulation and antiplatelet therapies after acute coronary episodes, major haemorrhages or strokes...
April 1, 2018: European Journal of Cardio-thoracic Surgery
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