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https://www.readbyqxmd.com/read/28944563/a-randomized-controlled-trial-of-levodopa-in-patients-with-angelman-syndrome
#1
Wen-Hann Tan, Lynne M Bird, Anjali Sadhwani, Rene L Barbieri-Welge, Steven A Skinner, Lucia T Horowitz, Carlos A Bacino, Lisa M Noll, Cary Fu, Rachel J Hundley, Logan K Wink, Craig A Erickson, Gregory N Barnes, Anne Slavotinek, Rita Jeremy, Alexander Rotenberg, Sanjeev V Kothare, Heather E Olson, Annapurna Poduri, Mark P Nespeca, Hillary C Chu, Jennifer M Willen, Kevin F Haas, Edwin J Weeber, Paul A Rufo
Treatment for Angelman syndrome (AS) is currently limited to symptomatic interventions. A mouse model of AS has reduced calcium/calmodulin-dependent kinase II activity due to excessive phosphorylation of specific threonine residues, leading to diminished long-term potentiation. In a rat model of Parkinson disease, levodopa reduced phosphorylation of various proteins, including calcium/calmodulin-dependent kinase II. Further studies demonstrated that AS mice treated with levodopa performed better on rotarod testing than untreated AS mice...
September 25, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28944321/effect-of-evacuation-and-displacement-on-the-association-between-flooding-and-mental-health-outcomes-a-cross-sectional-analysis-of-uk-survey-data
#2
Alice Munro, R Sari Kovats, G James Rubin, Thomas David Waite, Angie Bone, Ben Armstrong
BACKGROUND: Extensive flooding occurred during the winter of 2013-14 in England. Previous studies have shown that flooding affects mental health. Using data from the 2013-14 Public Health England National Study of Flooding and Health, we compared the prevalence of symptoms of depression, anxiety, and post-traumatic stress disorder between participants displaced by flooding and those flooded, but not displaced, 1 year after flooding. METHODS: In this multivariable ordinal regression analysis, we collected data from a cross-sectional survey collected 1 year after the flooding event from flood-affected postcodes in five counties in England...
July 2017: The Lancet. Planetary health
https://www.readbyqxmd.com/read/28944159/the-future-of-periodontal-systemic-associations-raising-the-standards
#3
REVIEW
P Mark Bartold, Angelo Mariotti
PURPOSE OF REVIEW: Periodontal medicine recognizes a "bidirectional" interaction between periodontitis and systemic conditions. Unfortunately, the facile ability to publish a periodontal-systemic association, regardless of biologic plausibility or rigorous scientific scrutiny, continues without abate. RECENT FINDINGS: The increasing number of periodontal-systemic associations corrupts the ability of dentists to distinguish which of the associations are spurious and which are valid...
2017: Current Oral Health Reports
https://www.readbyqxmd.com/read/28944126/oral-hygiene-practices-and-teeth-cleaning-techniques-among-medical-students
#4
Sajida Naseem, Syeda H Fatima, Haider Ghazanfar, Sana Haq, Najeeb A Khan, Moeez Mehmood, Ali Ghazanfar
Objectives Oral health is essential for general health and quality of life. It is a state of being free from mouth and facial pain, oral and throat cancer, oral infections and sores, periodontal disease, tooth decay, tooth loss, and other diseases and disorders that limit an individual's capacity to bite, chew, smile, and speak; it affects psychosocial well-being too. The objective of our study was to assess teeth cleaning techniques and oral hygiene practices among medical students. Methods The data of the study were collected in two stages...
July 18, 2017: Curēus
https://www.readbyqxmd.com/read/28944045/child-psychiatry-a-scientometric-analysis-1980-2016
#5
Sadiq Naveed, Ahmed Waqas, Salman Majeed, Muhammad Zeshan, Nusrat Jahan, Muhammad Haaris Sheikh
Background: The field of child and adolescent psychiatry lags behind adult psychiatry significantly. In recent years, it has witnessed a significant increase in the publication of journals and articles. This study provides a detailed bibliometric analysis of articles published from 1980 to 2016, in the top seven journals of child and adolescent psychiatry. Methods: Using the Web of Science core collection, we selected 9,719 research papers published in seven psychiatric journals from 1980 to 2016. We utilized the Web of Science Analytics tool and Network Analysis Interface for Literature Studies (NAILS) Project scripts to delineate the general trends of publication in these journals...
2017: F1000Research
https://www.readbyqxmd.com/read/28942204/can-flow-experiences-be-protective-of-work-related-depressive-symptoms-and-burnout-a-genetically-informative-approach
#6
Miriam A Mosing, Ana Butkovic, Fredrik Ullén
BACKGROUND: Genetic research on depression and burnout has focused mostly on adverse factors, although various aspects in daily life related to positive coping and well-being have been shown to potentially be protective. Using a large genetically informative sample, we aim to explore the potential relationship between flow proneness and work-related depressive symptoms and burnout. METHODS: About 10,000 Swedish twins filled in the Swedish Flow Proneness Questionnaire, a subscale of the Hopkins Symptom Checklist (SCL) depression scale, and the Emotional Exhaustion subscale of the Maslach Burnout Inventory-General Survey...
September 18, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28941967/prescribed-exercise-programs-may-not-be-effective-in-reducing-impairments-and-improving-activity-during-upper-limb-fracture-rehabilitation-a-systematic-review
#7
Andrea M Bruder, Nora Shields, Karen J Dodd, Nicholas F Taylor
QUESTION: What is the effect of exercise on increasing participation and activity levels and reducing impairment in the rehabilitation of people with upper limb fractures? DESIGN: Systematic review of controlled trials. PARTICIPANTS: Adults following an upper limb fracture. INTERVENTION: Any exercise therapy program, including trials where exercise was delivered to both groups provided that the groups received different amounts of exercise...
September 20, 2017: Journal of Physiotherapy
https://www.readbyqxmd.com/read/28941280/optimizing-the-amount-of-simulation-training-used-to-teach-vaginal-delivery-skills-to-medical-students
#8
Joshua F Nitsche, Timberly Butler, Alison Shew, Sha Jin, Brian C Brost
OBJECTIVE: To determine the amount of simulation training required for students to attain minimal competence and mastery of a vaginal delivery. METHODS: An observational study was conducted at a US medical school between May 11, 2015, and May 8, 2016. Using a modified Angoff method, 10 members of the Obstetrics and Gynecology faculty evaluated a vaginal delivery procedural checklist and established cutoff scores for minimal competence and mastery. During a 5-week period, all third-year students received between two and five 45-minute vaginal delivery simulation sessions; performance was assessed at week 6...
September 23, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28941259/an-open-label-extension-long-term-study-of-the-safety-and-efficacy-of-aripiprazole-for-irritability-in-children-and-adolescents-with-autistic-disorder-in-japan
#9
Hironobu Ichikawa, Michio Hiratani, Akihiro Yasuhara, Noa Tsujii, Takashi Oshimo, Hiroaki Ono, Yoshihiro Tadori
AIMS: The purpose of this study was to evaluate the long-term safety and efficacy of aripiprazole in treating irritability in pediatric patients (6-17 years) with autistic disorder (AD) in Japan. METHODS: In this open-label extension study, patients who completed a previous randomized, double-blind, placebo-controlled 8-week study were enrolled and were flexibly dosed with aripiprazole (1-15 mg/day) until the new indication of irritability in pediatric autism spectrum disorder was approved in Japan...
September 23, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28941221/how-well-do-rheumatology-fellows-manage-acute-infusion-reactions-a-pilot-curricular-intervention
#10
Jason J Weiner, Amanda M Eudy, Lisa G Criscione-Schreiber
BACKGROUND: Infusible DMARDs are commonly prescribed in rheumatology and other fields. There are no published formal educational curricula rheumatology fellowship programs can use to teach infusion reaction management skills to fellows. We aimed to better understand this educational gap, and implement and assess the effectiveness of an experiential curriculum on acute infusion reaction management. METHODS: We included current rheumatology fellows and recent graduates from five fellowship programs...
September 21, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28940670/deoxygenation-of-inspiratory-muscles-during-cycling-hyperpnoea-and-loaded-breathing-in-health-and-disease-a-systematic-review
#11
REVIEW
Takako Tanaka, Nada Basoudan, Luana T Melo, Lisa Wickerson, Laurent J Brochard, Ewan C Goligher, W Darlene Reid
Assessing inspiratory muscle deoxygenation and blood flow can provide insight into anaerobic stress, recruitment strategies and mechanisms of inspiratory muscle limitation. Therefore, this review aimed to synthesize measurements of inspiratory muscle oxyhaemoglobin (O2 Hb), deoxyhaemoglobin (HHb), blood volume and flow of the inspiratory muscles acquired via near-infrared spectroscopy (NIRS) during cycling, hyperpnoea and loaded breathing in healthy non-athletes, healthy athletes and patients with chronic obstructive pulmonary disease (COPD) or chronic heart failure (CHF)...
September 22, 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/28940247/enhancing-patient-safety-in-the-operating-theatre-from-the-perspective-of-experienced-operating-theatre-nurses
#12
Eydis Ingvarsdottir, Sigridur Halldorsdottir
THE STUDY'S RATIONALE: Surgical care is an extensive component of modern health care, but patient safety issues and complications of surgery have been identified as a major cause of death and disability. OBJECTIVE: The aim of this study was to identify, from the perspective of experienced operating theatre nurses (OTNs), how patient safety in the operating theatre (OT) can be enhanced. RESEARCH METHODOLOGY AND METHODS: In this phenomenological study, 14 individual interviews were conducted with a purposive sample of 11 participants: ten women and one man...
September 22, 2017: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/28939466/the-use-of-a-checklist-improves-anaesthesiologists-technical-and-non-technical-performance-for-simulated-malignant-hyperthermia-management
#13
Hardy Jean-Baptiste, Gouin Antoine, Damm Cédric, Compère Vincent, Veber Benoît, Dureuil Bertrand
No abstract text is available yet for this article.
September 19, 2017: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/28939370/peer-led-culinary-skills-intervention-for-adolescents-pilot-study-of-the-impact-on-knowledge-attitude-and-self-efficacy
#14
Amanda R Oakley, Sarah A Nelson, Sharon M Nickols-Richardson
OBJECTIVE: To assess the impact and feasibility of a culinary skills intervention for adolescents led by peer educators compared with adult educators. METHODS: Adolescents (aged 11-14 years) were randomized to peer educator (n = 22) or adult educator (n = 20) groups and attended 2 2.5-hour culinary skills lessons addressing knife skills, cooking methods, and recipes. Knowledge, attitude, and self-efficacy measurements were completed before and immediately after the intervention and at 3 and 6 months after the intervention...
September 19, 2017: Journal of Nutrition Education and Behavior
https://www.readbyqxmd.com/read/28939015/the-role-of-self-efficacy-on-the-prognosis-of-chronic-musculoskeletal-pain-a-systematic-review
#15
REVIEW
Javier Martinez-Calderon, Carmen Zamora-Campos, Santiago Navarro-Ledesma, Alejandro Luque-Suarez
Evidence suggests that self-efficacy can play an essential role as a protective factor as well as a mediator in the relationship between pain-disability in people suffering from chronic musculoskeletal pain. This study systematically reviewed and critically appraised the role of self-efficacy on the prognosis of chronic musculoskeletal pain. Study selection was based on longitudinal studies testing the prognostic value of self-efficacy in chronic musculoskeletal pain. The Newcastle-Ottawa Scale, the Cochrane Collaboration's tool, and the Methodological Index for Non-Randomized Studies (MINORS) checklist were used to evaluate the risk of bias of included studies...
September 19, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28938872/effect-of-vitamin-a-supplementation-on-gut-microbiota-in-children-with-autism-spectrum-disorders-a-pilot-study
#16
Juan Liu, Xiao Liu, Xue-Qin Xiong, Ting Yang, Ting Cui, Na-Li Hou, Xi Lai, Shu Liu, Min Guo, Xiao-Hua Liang, Qian Cheng, Jie Chen, Ting-Yu Li
BACKGROUND: Dysbiosis of gut microbiota are commonly reported in autism spectrum disorder (ASD) and may contribute to behavioral impairment. Vitamin A (VA) plays a role in regulation of gut microbiota. This study was performed to investigate the role of VA in the changes of gut microbiota and changes of autism functions in children with ASD. RESULTS: Sixty four, aged 1 to 8 years old children with ASD completed a 6-month follow-up study with VA intervention. High-performance liquid chromatography was used to assess plasma retinol levels...
September 22, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28938300/enhancing-the-quality-and-safety-of-the-perioperative-patient
#17
Sven Staender, Andrew Smith
PURPOSE OF REVIEW: Many possible hazards bedevil the perioperative patient. This review focuses on a number of aspects of perioperative management where the patient's quality and safety can be enhanced. RECENT FINDINGS: Our understanding of the relationship between preoperative preparation and postoperative outcomes has improved. There have also been recent developments in our understanding of how to construct useful cognitive aids and make the best use of checklists by understanding the cultural environment supporting their use...
September 21, 2017: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/28937719/revised-statement-on-safe-surgery-checklists-and-ensuring-correct-patient-correct-site-and-correct-procedure-surgery
#18
(no author information available yet)
No abstract text is available yet for this article.
October 2016: Bulletin of the American College of Surgeons
https://www.readbyqxmd.com/read/28937563/checklist
#19
(no author information available yet)
No abstract text is available yet for this article.
October 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28936792/alpha-theta-neurofeedback-increases-mentalization-and-default-mode-network-connectivity-in-a-non-clinical-sample
#20
Claudio Imperatori, Giacomo Della Marca, Noemi Amoroso, Giulia Maestoso, Enrico Maria Valenti, Chiara Massullo, Giuseppe Alessio Carbone, Anna Contardi, Benedetto Farina
Several studies showed the effectiveness of alpha/theta (A/T) neurofeedback training in treating some psychiatric conditions. Despite the evidence of A/T effectiveness, the psychological and neurobiological bases of its effects is still unclear. The aim of the present study was to explore the usefulness of the A/T training in increasing mentalization in a non-clinical sample. The modifications of electroencephalographic (EEG) functional connectivity in Default Mode Network (DMN) associated with A/T training were also investigated...
September 21, 2017: Brain Topography
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