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https://www.readbyqxmd.com/read/29611085/paradoxical-skin-lesions-induced-by-anti-tnf-%C3%AE-agents-in-sapho-syndrome
#1
Chen Li, Xia Wu, Yihan Cao, Yueping Zeng, Weihong Zhang, Shuo Zhang, Yuehua Liu, Hongzhong Jin, Wen Zhang, Li Li
The objectives of the study were to characterize the clinical picture of paradoxical skin lesions in SAPHO patients treated with anti-TNF-α agents and to explore its pathogenesis. Patients treated with anti-TNF-α therapy were identified from a cohort of 164 SAPHO patients. The clinical data and skin biopsies were collected. The usage, efficacy, and side effects of anti-TNF-α therapy were recorded. Forty-one (25.0%) patients received anti-TNF-α therapy, of which seven (17.1%) developed paradoxical skin lesions after 1 to 14 infusions...
April 3, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29531495/pustulotic-arthro-osteitis-sonozaki-syndrome-a-case-report-and-review-of-literature
#2
Reyhan Kose, Taskin Senturk, Gokhan Sargin, Songul Cildag, Yasemin Kara
Pustulotic arthro-osteitis (PAO) is a rare chronic inflammatory disease, which has now been classified as a seronegative spondyloarthritis. The sternoclavicular and sternocostal joints, pelvis, vertebra, hip, and long bones are affected. Skin findings of the disease are accepted as a variant of pustular psoriasis, but some authors have suggested that palmoplantar pustulosis (PPP) is a different entity. The synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome should be considered in the differential diagnosis...
February 2018: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/29387665/mandibular-involvement-in-recurrent-multifocal-osteomyelitis-associated-with-sapho-syndrome
#3
Igor-Moreira Hazboun, Thiago-Pires Brito, Vanessa-Gonçalves Silva, Carlos-Eduardo-Monteiro Zappelini, Leopoldo-Nizam Pfeilsticker
Introduction: SAPHO syndrome is defined as the association of a group of rare sterile osteoarticular disorders and inflammatory skin diseases whose etiology, although not yet determined, probably involves genetic, immunological and infectious mechanisms. The recurrent multifocal osteomyelitis, an inflammatory disease, can be associated with this syndrome even as a single event. Case Report: A case of a young female patient, with a definite diagnosis of SAPHO and an inflammatory mandibular atypical disease for which therapeutic options with immunosuppressants were being used, is reported...
January 2018: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29382023/case-report-remarkable-remission-of-sapho-syndrome-in-response-to-tripterygium-wilfordii-hook-f-treatment
#4
Chen Li, Xiaochuan Sun, Yihan Cao, Wenrui Xu, Wen Zhang, Zhenhua Dong
RATIONALE: SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome is an autoinflammatory disease with no standardized treatment. Tripterygium wilfordii hook f (TwHF) is a Chinese herb with immunosuppressive effects and has been used to treat some chronic inflammatory diseases. However, it has not been reported as a therapeutic option in SAPHO syndrome. Here we present the first report in which a remarkable remission of SAPHO syndrome was achieved in response to TwHF...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29323824/a-case-of-atypical-synovitis-acne-pustulosis-hyperostosis-osteitis-sapho-syndrome-presenting-with-osteomyelitis-of-the-clavicle
#5
Chetan Sharma, Brian Chow
Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome is considered after exclusion of infection and arthritis; however, microbial infection may be present in osteoarticular lesions of these patients. Chronic osteomyelitis and associated bacterial infection were detected in a recurrent osteoarticular lesion in an adolescent patient with a history of clavicle pain, who complained of recurrent swelling in the left clavicle. Most pediatric case reports of SAPHO syndrome describe patients with associated skin conditions...
June 2017: WMJ: Official Publication of the State Medical Society of Wisconsin
https://www.readbyqxmd.com/read/29276872/successful-treatment-of-a-childhood-synovitis-acne-pustulosis-hyperostosis-and-osteitis-sapho-syndrome-with-subcutaneous-methotrexate-a-case-report
#6
Meltem Akçaboy, Sevcan Azime Bakkaloğlu-Ezgü, Bahar Büyükkaragöz, Emel Isıyel, Yasar Kandur, Enver Hasanoğlu, Necla Buyan
Akçaboy M, Bakkaloğlu-Ezgü SA, Büyükkaragöz B, Isıyel E, Kandur Y, Hasanoğlu E, Buyan N. Successful treatment of a childhood synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome with subcutaneous methotrexate: A case report. Turk J Pediatr 2017; 59: 184-188. SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis and osteitis) is defined as a syndrome that is related to various osteoarticular manifestations and chronic dermatological conditions especially severe acne. SAPHO syndrome is a rare and unusual clinical entity in childhood and treatment choices are variable...
2017: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/29251057/clinical-heterogeneity-of-sapho-syndrome-challenge-of-diagnosis
#7
Chen Li, Yihan Cao, Wen Zhang
No abstract text is available yet for this article.
January 5, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29212418/clinical-characteristics-and-outcome-of-childhood-acute-promyelocitic-leukemia-apl-in-saudi-arabia-a-multicenter-saphos-leukemia-group-study
#8
Wasil Jastaniah, Abdulrahman Alsultan, Saad Al Daama, Walid Ballourah, Mohamed Bayoumy, Faisal Al-Anzi, Omar Al Shareef, Mohammed Burhan Abrar, Reem Al Sudairy, Ibrahim Al Ghemlas
BACKGROUND: Acute promyelocytic leukemia (APL) is a rare form of acute myelogenous leukemia (AML). Survival rates exceed 80% in developed countries. Successful treatments rely on all-trans retinoic acid with anthracycline-based chemotherapy. Availability of modern care and public knowledge play important roles in pediatric APL survival. METHOD: A cytogenetic diagnosis of APL was confirmed in 30 (14.5%) out of 207 children consecutively diagnosed with de novo AML between January 2005 and December 2012 at nine cancer care centers in Saudi Arabia...
December 7, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/29185291/clinical-images-marked-inflammation-in-a-patient-with-cervical-vertebral-sapho-complicated-by-vertebral-body-collapse-and-severe-kyphosis
#9
Sara Borok, Gideon Flusser, Ori Elkayam
No abstract text is available yet for this article.
November 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29034454/successful-treatment-of-sapho-syndrome-with-apremilast
#10
S Adamo, J Nilsson, A Krebs, U Steiner, A Cozzio, L E French, A G A Kolios
SAPHO (synovitis, acne, pustulosis, hyperostosis and osteitis) syndrome is a rare disease with inflammatory osteoarticular and skin involvement. The pathogenesis of SAPHO syndrome remains unclear, but evidence suggests it may be an autoinflammatory disease triggered upon exposure to infectious agents in genetically predisposed individuals. Induction of the interleukin (IL)-23/T helper 17 axis in addition to neutrophil activation seem to play a key role, and therapies targeting these immunological pathways, including tumour necrosis factor (TNF) inhibitors, ustekinumab, secukinumab and the IL-1 inhibitor anakinra, are potential treatment options that need further investigation...
October 16, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29033438/small-cell-lung-cancer-associated-with-sapho-syndrome
#11
Kosuke Imamura, Shinya Sakata, Yasumiko Sakamoto, Sho Saeki
No abstract text is available yet for this article.
January 1, 2018: Internal Medicine
https://www.readbyqxmd.com/read/28977552/synovitis-acne-pustulosis-hyperostosis-osteitis-sapho-paradoxical-reactions-and-different-responses-to-tumour-necrosis-factor-inhibitors
#12
Jean Liew, Teena Huan Xu, Cong-Qiu Chu
No abstract text is available yet for this article.
December 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28968231/pustulotic-arthro-osteitis-sonozaki-syndrome-a-rare-case-report
#13
Hatice Resorlu, Besir Sahin Inceer, Sevilay Kılıc, Selda Isık
Pustulotic arthro-osteitis is a rare disease involving the skin and musculoskeletal system that was first described by Sonozaki. Onset is frequently seen at age 30-40. The prevalences between the sexes are similar. Palmoplantar pustulosis and sternoclavicular joint involvement are the most typical findings. It may be difficult to distinguish seronegative spondyloarthropathies and SAPHO syndrome due to sacroiliac joint, vertebral column and peripheral joint involvement. Arthritis being non-erosive and short-lived in character and the absence of deformity or contracture in the joints are significant clinical characteristics...
September 22, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28924111/synovitis-acne-pustulosis-hyperostosis-osteitis-sapho-syndrome-with-significant-bilateral-pleural-effusions
#14
Shoichi Hasegawa, Hiroki Yabe, Naoya Kaneko, Eri Watanabe, Takahisa Gono, Chihiro Terai
We herein report a rare case of a 66-year-old woman who had synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome with marked sternal osteitis and bilateral pleural effusions. SAPHO syndrome was diagnosed based on the characteristic features of a hyperostotic sternum and thoracic spine. The inflammatory changes of sternal osteitis and involvement of the adjacent soft tissue were assumed to be the cause of the pleural effusions. The effusions decreased during the natural course of the disease and resolved after methotrexate therapy...
October 15, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28884797/sapho-syndrome-associated-with-hidradenitis-suppurativa-and-pyoderma-gangrenosum-successfully-treated-with-adalimumab-and-methotrexate-a-case-report-and-review-of-the-literature
#15
REVIEW
Dunja A Vekic, Jane Woods, Peter Lin, Geoffrey D Cains
SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome is a rare inflammatory condition describing the combination of skin, bone, and joint manifestations that has a heterogeneous presentation. We report a case of severe SAPHO syndrome in association with hidradenitis suppurativa and pyoderma gangrenosum in a 27-year-old male. The patient had an initial migratory arthritis affecting the knees, ankles, metacarpophalangeal joints, proximal interphalangeal joints, wrists, shoulder, and lower back, which progressed to a persistent arthritis and swelling at the sternum, shoulders, wrists, hands, feet, and lower back...
January 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/28880693/clinical-features-and-radiological-findings-of-67-patients-with-sapho-syndrome
#16
Hiroshi Okuno, Munenori Watanuki, Yoshiyuki Kuwahara, Akira Sekiguchi, Yu Mori, Shin Hitachi, Keiki Miura, Ken Ogura, Mika Watanabe, Masami Hosaka, Masahito Hatori, Eiji Itoi, Katsumi Sato
OBJECTIVES: The purpose of this study was to facilitate the understanding of the SAPHO (Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis) syndrome by analyzing the clinical and radiological features of 67 Japanese patients with SAPHO syndrome. METHODS: Sixty-seven Japanese patients (female/male: 44/23, mean age at onset: 48.5 years) were diagnosed with SAPHO syndrome from 2002 to 2013 at our hospital. Medical records and radiological imaging of these patients were retrospectively reviewed...
September 21, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28774447/sapho-and-recurrent-multifocal-osteomyelitis
#17
REVIEW
Simon Greenwood, Antonio Leone, Victor N Cassar-Pullicino
SAPHO and recurrent multifocal osteomyelitis are complex inflammatory conditions that clinical radiologists play an essential part in diagnosing. They present with a wide range of musculoskeletal and skin manifestations, and exhibit several key diagnostic features that, when present, make the diagnoses unequivocal. The overall population group is young. Diagnostic delay is common with a relapsing and remitting clinical course and often subtle early radiologic findings. This article provides an up-to-date insight into both conditions, including their multifaceted pathogenesis, effective therapeutic options, and advanced imaging features, to arm radiologists with the knowledge required to make the diagnoses confidently in a timely manner...
September 2017: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/28765183/a-case-of-bronchiolitis-obliterans-organising-pneumonia-associated-with-sapho-synovitis-acne-pustulosis-hyperostosis-osteitis-syndrome
#18
Fawad Hameed, Henry Steer
A 57-year-old woman with SAPHO (synovitis-acne-pustulosis-hyperostosis-osteitis) syndrome presented with recurrent episodes of pneumonia. She was treated with multiple courses of antibiotics with no success. The transbronchial biopsy undertaken via bronchoscopy revealed organising pneumonia (OP). She was treated with steroids and responded well with full clinical recovery and normalisation of her chest X-ray.To our knowledge, this is the first reported case of OP in association with SAPHO syndrome. This case report highlights the importance of considering OP in patients with SAPHO syndrome who present with chest infection...
August 1, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28725947/clinical-heterogeneity-of-sapho-syndrome-challenging-diagnose-and-treatment
#19
REVIEW
Francesco Cianci, Angelo Zoli, Elisa Gremese, Gianfranco Ferraccioli
Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome is a rare disease which is often misdiagnosed and under-recognized, because of its peculiar and heterogeneous clinical presentation. Its main features consist of cutaneous and osteoarticular manifestations, the latter affecting more often the anterior chest wall and having typical radiologic findings. There are no validated diagnostic criteria for SAPHO and no guidelines for treatment, due mainly to its rarity; as a consequence, therapy is empirical and aimed to control pain and modifying inflammatory process...
September 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28696038/recognizing-syndromic-hidradenitis-suppurativa-a-review-of-the-literature
#20
REVIEW
J Gasparic, P Theut Riis, G B Jemec
Hidradenitis suppurativa (HS) is an inflammatory skin disease causing painful inflammation and suppuration. It may occur in rare syndromes: follicular occlusion, Bazex-Dupré-Christol, Down's, KID, PAPASH, PASS, PASH, and SAPHO syndromes, as well as Dowling-Degos disease. An overview of syndromic HS may inform the search for aetiological factors in HS. PubMed, Ovid and Web of Science were systematically searched using '(hidradenitis OR acne invers*) AND (syndrome OR KID OR PASS OR PAPA OR PASH OR SAPHO OR bazex-dupre OR 'dowling degos' OR triad OR tetrad)' and Cochrane Library using 'hidradenitis OR acne invers*'...
November 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
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