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https://www.readbyqxmd.com/read/28072711/the-coexistence-of-sapho-syndrome-and-rheumatoid-arthritis-a-case-report
#1
Wenrui Xu, Chen Li, Weihong Zhang
RATIONAL: SAPHO (Synovitis-Acne-Pustulosis-Hyperstosis-Osteitis) syndrome is a rare disease featured by its dermatological and osteoarthritic disorders, the latter of which mainly affecting the anterior chest wall, spine, and sacroiliac joint. However, rheumatoid arthritis (RA) is a chronic autoimmune disease, mainly affecting the synovial tissue of small joints in hands and feet. Here, we present an extremely rare case diagnosed with both SAPHO syndrome and RA, with an onset interval of 10 years...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28060551/scleritis-associated-with-sapho-syndrome-a-case-report
#2
Rie Tanaka, Keiichi Sakurai, Toshikatsu Kaburaki
A 31-year-old woman developed bilateral painful red eyes. A slit-lamp examination revealed anterior diffuse scleritis. She had been diagnosed with palmoplantar pustulosis 2 years before. Further evaluation revealed hyperostosis of the sacroiliac joint and inflammation of the bilateral sternoclavicular joints and right sternocostal joint. Ultimately, she was diagnosed with SAPHO syndrome by rheumatologists after excluding other causative diseases. Scleritis associated with SAPHO syndrome is relatively uncommon...
January 6, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27993538/sapho-syndrome-in-childhood-a-case-report
#3
Manuel Vargas Pérez, Belén Sevilla Pérez
The acronym of SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis and osteitis) combines a cluster of cutaneous and musculoskeletal manifestations, such as hyperostosis of bones of the anterior chest wall associated with acne fulminans and hidradenitis suppurativa. There are no validated diagnostic criteria in children. Nonsteroidal anti-inflammatory drugs are not always sufficient, and the use of corticosteroids, disease-modifying agents, tumor necrosis factor-α inhibitors or bisphosphonates may be necessary...
December 16, 2016: Reumatología Clinica
https://www.readbyqxmd.com/read/27936930/different-contributions-of-cdkal1-kif21b-and-lrrk2-muc19-polymorphisms-to-sapho-syndrome-rheumatoid-arthritis-ankylosing-spondylitis-and-seronegative-spondyloarthropathy
#4
Nan Li, Junfen Ma, Kai Li, Changlong Guo, Liang Ming
OBJECTIVES: Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome, rheumatoid arthritis (RA), ankylosing spondylitis (AS), and seronegative spondyloarthropathy (SPA) are autoimmune diseases of unknown etiology, which share some clinical manifestations in common. Previous family-based investigations support genetic contributions to the susceptibility of these diseases. The current study evaluated whether three previously reported AS-associated single-nucleotide polymorphisms (SNPs), rs6908425 T>C in CDKAL1, rs11584383 T>C near KIF21B, and rs11175593 C>T near LRRK2/MUC19, have any genetic overlap across multiple autoimmune diseases including SAPHO syndrome, RA, AS, and SPA...
December 12, 2016: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/27846749/synovitis-of-sternoclavicular-and-peripheral-joints-can-be-detected-by-ultrasound-in-patients-with-sapho-syndrome
#5
Masataka Umeda, Shin-Ya Kawashiri, Ayako Nishino, Tomohiro Koga, Kunihiro Ichinose, Toru Michitsuji, Toshimasa Shimizu, Shoichi Fukui, Yoshikazu Nakashima, Yasuko Hirai, Naoki Iwamoto, Toshiyuki Aramaki, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Yukitaka Ueki, Atsushi Kawakami
OBJECTIVES: To determine the prevalence of ultrasonographic abnormalities of sternoclavicular joints (SCJ) and peripheral joints (PJ) in patients with synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome. METHODS: Thirteen patients with SAPHO syndrome who fulfilled diagnostic criteria proposed by Kahn for SAPHO syndrome 2003 and 13 healthy individuals age- and sex-matched were enrolled. Synovitis, defined by synovial hypertrophy with power Doppler (PD) signals, of the SCJ and the PJ including wrist, MCP, PIP, and the other symptomatic joints were evaluated by ultrasound (US)...
December 9, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27785852/severe-osteoarticular-involvement-in-isotretinoin-triggered-acne-fulminans-two-cases-successfully-treated-with-anakinra
#6
T Oranges, A Insalaco, A Diociaiuti, C Carnevale, R Strippoli, G Zambruno, P Tomà, M El Hachem
Acne fulminans (AF) is a severe form of inflammatory and ulcerated acne associated with fever, malaise, joint swellings and polyarthralgia(1) . Osteoarticular lesions are often described and can be radiologically indistinguishable from those observed in synovitis - acne - pustulosis - hyperostosis and osteitis (SAPHO) syndrome(2,3) . SAPHO is an autoinflammatory disease characterized by osteoarticular and cutaneous manifestations, the latter including nodular and fulminans acne, hidroadenitis suppurativa, and palmo-plantar pustolosis(3) ...
October 27, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27742022/imaging-for-synovitis-acne-pustulosis-hyperostosis-and-osteitis-sapho-syndrome
#7
Steven Schaub, Hartley M Sirkis, Jonathan Kay
Multifocal osteomyelitis and synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome constitute a spectrum of disease that includes inflammatory bone lesions and dermatologic findings. Radiographic features resemble those of the spondyloarthropathies with anterior chest wall involvement. Early radiographic findings are osteodestructive with lytic lesions. Bone scintigraphy of the sternoclavicular region classically yields a 'bull's head' pattern of radionuclide uptake. Magnetic resonance imaging (MRI) can demonstrate corner lesions of vertebral bodies...
November 2016: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/27730042/sapho-syndrome-with-acne-fulminans-and-severe-polyosteitis-involving-axial-skeleton
#8
B Lakshmi Divya, P Narasimha Rao
SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, osteitis), a rare inflammatory disorder, is an association of distinct skin disorders with pustules with osteoarticular inflammation. Its etiology remains unclear, and various treatment regimens frequently fail to control the disease. An 18-year-old male patient presented to the outpatient department with severe nodulocystic acne on the face with pain at both the wrists and lower back associated with high-grade fever and chills. On physical examination, he had severe tenderness at both wrist joints and lower back, along with swelling of right wrist...
September 2016: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/27698770/multimodal-imaging-findings-of-sapho-syndrome-with-no-skin-lesions-a-report-of-three-cases-and-review-of-the-literature
#9
Na Duan, Xiao Chen, Yongkang Liu, Jianhua Wang, Zhongqiu Wang
Synovitis, acne, palmoplantar pustulosis, hyperostosis and osteitis syndrome (SAPHO) is a rare syndrome that affects the skin, bones and joints. Diagnosis of SAPHO syndrome is established on clinical appearance and imaging features. The present case report described the imaging features of three cases of SAPHO with sternoclavicular joint arthritis but without skin manifestations using multiple imaging modalities, including computed tomography (CT), magnetic resonance imaging (MRI) and bone scintigraphy. The first case was a 52-year-old male who suffered from progressive sternoclavicular arthritis for 2 years...
October 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27580158/clinical-characteristics-and-outcome-of-childhood-de-novo-acute-myeloid-leukemia-in-saudi-arabia-a-multicenter-saphos-leukemia-group-study
#10
Wasil Jastaniah, Ibrahim Al Ghemlas, Saad Al Daama, Walid Ballourah, Mohammad Bayoumy, Faisal Al-Anzi, Omar Al Shareef, Abdulrahman Alsultan, Mohammed Burhan Abrar, Reem Al Sudairy
Geographic variation and ethnicity have been implicated to influence the outcome of pediatric acute myeloid leukemia (AML). Furthermore, survival outcomes from developing countries are reported to be inferior to developed nations. We hypothesized that risk- and response-based outcome in high-income resource-rich developing countries would be comparable to developed nations as access to care and supportive measures would be similar. A total of 193 children diagnosed with de novo AML between January 2005 and December 2012 were identified, of those 175 were evaluable for outcome...
October 2016: Leukemia Research
https://www.readbyqxmd.com/read/27528491/-sapho-syndrome-a-case-of-a-patient-with-anterior-musculoskeletal-chest-pain-and-palmoplantar-pustulosis-treated-successfully-with-golimumab
#11
F Abadín López, E Revuelta Evrard
No abstract text is available yet for this article.
August 12, 2016: Semergen
https://www.readbyqxmd.com/read/27527220/sternocostoclavicular-hyperostosis-an-ill-recognized-disease
#12
Bolette Roed, Tatiana Kristensen, Søren Thorsen, Klaus Poulsen Bloch, Pia Afzelius
Sternocostoclavicular hyperostosis (SCCH) is an ill-recognized, rarely diagnosed disease. Today, SCCH is widely considered part of the synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome. SCCH develops over years with intermittent attacks of pain, swelling, and reddening of the sternocostoclavicular region. The disease causes progressive hyperostosis, fusion of the sternocostoclavicular joints, and soft tissue ossification. SCCH is chronic, non-malignant, and occurs predominantly bilaterally in middle-aged women...
August 5, 2016: Diagnostics
https://www.readbyqxmd.com/read/27527149/serum-interleukin-18-fetuin-a-soluble-intercellular-adhesion-molecule-1-and-endothelin-1-in-ankylosing-spondylitis-psoriatic-arthritis-and-sapho-syndrome
#13
Hanna Przepiera-Będzak, Katarzyna Fischer, Marek Brzosko
To examine serum interleukin 18 (IL-18), fetuin-A, soluble intercellular adhesion molecule-1 (sICAM-1), and endothelin-1 (ET-1) levels in ankylosing spondylitis (AS), psoriatic arthritis (PsA), and Synovitis Acne Pustulosis Hyperostosis Osteitis syndrome (SAPHO). We studied 81 AS, 76 PsA, and 34 SAPHO patients. We measured serum IL-18, fetuin-A, sICAM-1, ET-1, IL-6, IL-23, vascular endothelial growth factor (VEGF), and epidermal growth factor (EGF). IL-18 levels were higher in AS (p = 0.001), PsA (p = 0.0003), and SAPHO (p = 0...
August 3, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27456988/interstitial-granulomatous-dermatitis-occurring-in-a-patient-with-sapho-syndrome-one-month-after-starting-leflunomide-and-subsequently-disappearing-with-ustekinumab
#14
Hélène Cornillier, Thibault Kervarrec, Flore Tabareau-Delalande, Saloua Mammou, Annie-Pierre Jonville Bera, Laurent Machet
No abstract text is available yet for this article.
December 1, 2016: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/27399138/a-case-report-of-severely-damaged-hip-joint-caused-by-sapho-syndrome-treated-with-2-stage-total-hip-arthroplasty
#15
Ingwon Yeo, Hoon-Suk Cha, Young Cheol Yoon, Youn-Soo Park, Seung-Jae Lim
INTRODUCTION: Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is an increasingly recognized entity. The hip joint is known as a less frequently affected site in SAPHO syndrome, and there has been limited reports about hip joint diseases caused by SAPHO syndrome, and as such adequate treatment for this disease spectrum is still not fully elucidated. CASE: We describe the case of a 52-year-old man admitted for SAPHO syndrome who went on to be diagnosed with advanced secondary hip arthritis associated with disabling right hip pain...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27369452/sapho-treatment-options-including-bisphosphonates
#16
Tom Zwaenepoel, Kurt de Vlam
INTRODUCTION: Both the diagnosis and treatment of the syndrome of synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) remain difficult. We describe a case series of 21 patients with SAPHO and their response to several pharmacological treatments. METHODS: Clinical and biochemical data, along with medical imaging, were collected from the medical records of 21 patients, diagnosed as SAPHO during follow-up between 2005 and 2013. Symptoms and inflammatory markers were recorded twice, once at first patient presentation, and once at the end of follow-up...
October 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/27291924/new-onset-vitiligo-and-progression-of-pre-existing-vitiligo-during-treatment-with-biological-agents-in-chronic-inflammatory-diseases
#17
L Méry-Bossard, K Bagny, G Chaby, A Khemis, F Maccari, H Marotte, J L Perrot, Z Reguiai, M L Sigal, M Avenel-Audran, T Boyé, A Grasland, J Gillard, D Jullien, E Toussirot
BACKGROUND: The development of vitiligo during treatment with biological agents is an unusual event and only a few isolated cases have been reported. OBJECTIVES: To describe the clinical characteristics and evolution of patients developing new-onset vitiligo following initiation of a biological agent for chronic inflammatory disease; and also to report the clinical course of pre-existing vitiligo under biological therapy. METHODS: This nationwide multicentre, retrospective study, carried out between July 2013 and January 2015, describes the characteristics of a large series of 18 patients (psoriasis N = 8, inflammatory rheumatic diseases N = 8, ulcerative colitis N = 1, uveitis N = 1) who developed new-onset vitiligo while receiving a biological agent...
January 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27263075/synovitis-acne-pustulosis-hyperostosis-and-osteitis-sapho-syndrome-a%C3%A2-challenging-diagnosis-not-to-be-missed
#18
Petra Zimmermann, Nigel Curtis
SAPHO syndrome manifests as chronic inflammation of bones and joints, which may or may not be accompanied by skin changes. The term SAPHO is an acronym that stands for synovitis, acne, pustulosis (usually palmoplantar), hyperostosis and osteitis. The bones most commonly affected are those in the anterior chest wall (mainly the sternum, clavicles and sternocostoclavicular joints), the vertebrae and the sacroiliac joints, but peripheral and flat bones may also be involved, especially in children. There are no validated diagnostic criteria for SAPHO, and diagnosis is based on clinical and radiological findings...
July 5, 2016: Journal of Infection
https://www.readbyqxmd.com/read/27181039/bilateral-subclavian-vein-occlusion-in-a-sapho-syndrome-patient-who-needed-an-implantable-cardioverter-defibrillator
#19
Masato Ishizuka, Yuko Yamamoto, Shintaro Yamada, Sonoko Maemura, Ryo Nakata, Yoshihiro Motozawa, Keisuke Yamamoto, Masataka Takizawa, Hiroki Uozumi, Hiroshi Ikenouchi
A 79-year-old Asian man was hospitalized because of progressive exertional dyspnea with decreasing left ventricular ejection fraction and frequent non-sustained ventricular tachycardia. Pre-procedure venography for implantable cardioverter defibrillator (ICD) implantation showed occlusion of the bilateral subclavian veins. In consideration of subcutaneous humps in the sterno-clavicular area and palmoplantar pustulosis, we diagnosed him as having synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome and speculated that it induced peri-osteal chronic inflammation in the sterno-clavicular area, resulting in occlusion of the adjacent bilateral subclavian veins...
May 25, 2016: International Heart Journal
https://www.readbyqxmd.com/read/27121779/neutrophils-from-patients-with-sapho-syndrome-show-no-signs-of-aberrant-nadph-oxidase-dependent-production-of-intracellular-reactive-oxygen-species
#20
Per Wekell, Halla Björnsdottir, Lena Björkman, Martina Sundqvist, Karin Christenson, Veronica Osla, Stefan Berg, Anders Fasth, Amanda Welin, Johan Bylund, Anna Karlsson
OBJECTIVE: We aimed to investigate if aberrant intracellular production of NADPH oxidase-derived reactive oxygen species (ROS) in neutrophils is a disease mechanism in the autoinflammatory disease SAPHO syndrome, characterized by synovitis, acne, pustulosis, hyperostosis and osteitis, as has previously been suggested based on a family with SAPHO syndrome-like disease. METHODS: Neutrophil function was explored in a cohort of four patients with SAPHO syndrome, two of whom were sampled during both inflammatory and non-inflammatory phase...
August 2016: Rheumatology
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