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https://www.readbyqxmd.com/read/29224742/the-importance-of-synovial-inflammation-in-osteoarthritis-current-evidence-from-imaging-assessments-and-clinical-trials
#1
REVIEW
Xia Wang, David J Hunter, Xingzhong Jin, Changhai Ding
Synovial abnormalities have been observed at multiple stages of osteoarthritis (OA). Increasing evidence suggests that it may play an important role in the OA pathological process. Many assessment systems using magnetic resonance imaging (MRI) and ultrasound have been established to detect synovial inflammation in OA. These have been used to inform the current investigation of OA disease phenotypes and progression and can be utilised in the future for clinical trials developing potential treatments. This narrative review aims to illustrate the importance of synovial tissue in OA and provide an overview of imaging assessments and possible therapies targeting synovial abnormalities...
December 7, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29196131/differential-involvement-of-synovial-adipokines-in-pain-and-physical-function-in-female-patients-with-knee-osteoarthritis-a-cross-sectional-study
#2
Joan Calvet, Cristóbal Orellana, Néstor Albiñana Giménez, Antoni Berenguer-Llergo, Assumpta Caixàs, María García-Manrique, Carlos Galisteo Lencastre, Noemí Navarro, Marta Larrosa, Jordi Gratacós
OBJECTIVE: Adipokines have been reported to play a role in the development, progression and severity of knee osteoarthritis but the influence of the different adipokines are not well known. The aim of this study was to evaluate the association between different synovial fluid adipokines with pain and disability knee osteoarthritis patients. METHODS: Cross-sectional study with systematic inclusion of 115 symptomatic primary knee osteoarthritis female patients with ultrasound-confirmed joint effusion...
November 28, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29172843/intra-articular-corticosteroid-injections-in-haemophilic-arthropathy-are-they-recommended
#3
E Carlos Rodriguez-Merchan
INTRODUCTION: Intra-articular (IA) corticosteroid (CS) injections are commonly used in the treatment of osteoarthritis. However, they are rarely utilized in haemophilic arthropathy. In fact, the efficacy of this method in haemophilic arthropathy is frequently discussed and debated in clinical practice. AIM: To investigate the effectiveness of IA CS injections in patients with painful haemophilic arthropathy. METHODS: A review of the literature on the topic was performed...
November 30, 2017: Hospital Practice (Minneapolis)
https://www.readbyqxmd.com/read/29164399/efficacy-of-a-single-intra-articular-injection-of-ultra-high-molecular-weight-hyaluronic-acid-for-hip-osteoarthritis-a-randomized-controlled-study
#4
Daniele Clementi, Riccardo D'Ambrosi, Paride Bertocco, Miguel Simon Bucci, Carlo Cardile, Paolo Ragni, Graziella Giaffreda, Vincenza Ragone
BACKGROUND: Viscosupplementation with hyaluronic acid (HA) is increasingly used for the treatment of hip osteoarthritis (OA). The purpose of this study was to compare the efficacy of intra-articular injections of an ultra-high molecular weight viscosupplement (UHMW-HA, Fermathron S) with a medium molecular weight hyaluronan (MMW-HA, Hyalubrix 60) in hip OA. METHODS: Fifty-four patients with hip OA grade 3 on the Kellgren/Lawrence scale were randomized. All infiltrations were performed under ultrasound guidance...
November 21, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29120570/early-referral-improves-long-term-outcomes-in-rheumatoid-arthritis
#5
Jobie Evans, Andra Negoescu
Rheumatoid arthritis (RA) is a common, chronic systemic inflammatory disease of unclear aetiology leading to synovial hypertrophy and joint inflammation. It typically presents with symmetrical polyarthritis of small joints of the hands or feet, but can also involve larger joints, and have associated extra-articular manifestations. Diagnosis is based on duration of symptoms, joint distribution, level of inflammatory markers and autoantibodies i.e. rheumatoid factor(RhF) and anty-cyclic citrullinated peptide (CCP) antibodies...
May 2017: Practitioner
https://www.readbyqxmd.com/read/29111161/effect-of-low-intensity-pulsed-ultrasound-on-joint-injury-and-post-traumatic-osteoarthritis-an-animal-study
#6
Talal Zahoor, Reed Mitchell, Priya Bhasin, Yi Guo, Sharada Paudel, Lew Schon, Zijun Zhang
This study investigated the therapeutic potential of low-intensity pulsed ultrasound (LIPUS) in post-traumatic osteoarthritis (PTOA). Intra-articular fracture of the medial tibial plateau was surgically created in 30 rats. LIPUS was applied to the operated joints either for the first 2 wk (LIPUS1-2 group) or in weeks 4 and 5 after intra-articular fracture (LIPUS4-5 group). In controls, the operated knees were not treated with LIPUS (LIPUS0 group). The rats were monitored with weekly gait analysis and euthanized at week 8...
October 27, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29102985/study-protocol-for-a-randomised-controlled-trial-of-ultrasound-guided-pulsed-radiofrequency-of-the-genicular-nerves-in-the-treatment-of-patients-with-osteoarthritis-knee-pain
#7
Javier Mata, Pedro Valentí, Beatriz Hernández, Bartolome Mir, Jose Luis Aguilar
INTRODUCTION: The goals for the management of patients with osteoarthritis (OA) of the knee are to control pain and to minimise disability. Because the number of patients will increase as the population ages, alternative approaches to alleviate their joint pain other than conventional treatments are necessary. The purpose of this article is to present a refined protocol to determine if there is long-term improvement in pain and function after ultrasound-guided pulsed radiofrequency treatment of the genicular nerves (GNs) in patients with chronic painful knee OA...
November 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/29080986/use-of-the-t%C3%A3-bingen-splint-for-the-initial-management-of-severely-dysplastic-and-unstable-hips-in-newborns-with-ddh-an-alternative-to-fettweis-plaster-and-pavlik-harness
#8
Hannes Kubo, Hakan Pilge, Kristina Weimann-Stahlschmidt, Karoline Stefanovska, Bettina Westhoff, Ruediger Krauspe
AIM: Hip dysplasia is one of the most common skeletal disorders. As a late consequence 20-25% of the patients are at risk to develop secondary osteoarthritis and may require total hip replacement early in life. The treatment principles of hip dislocation are (1) concentric reposition, (2) retention, i.e., plaster in human post or Pavlik harness and (3) maturation in abduction flexion orthesis. The Tübingen splint was introduced as a further development of abduction devices for the treatment of (residual) hip dysplasia with stable hips...
October 28, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29080286/evolve-the-australian-rheumatology-association-s-top-five-list-of-investigations-and-interventions-doctors-and-patients-should-question
#9
Kathleen Morrisroe, Ayano Nakayama, Jason Soon, Mark Arnold, Les Barnsley, Claire Barrett, Peter M Brooks, Stephen Hall, Patrick Hanrahan, Pravin Hissaria, Graeme Jones, Veera Srividya Katikireddi, Helen Keen, Rodger Laurent, Mandana Nikpour, Katherine Poulsen, Philip Robinson, Muriel Soden, Nigel Wood, Nicola Cook, Catherine Hill, Rachelle Buchbinder
BACKGROUND: The EVOLVE (evaluating evidence. enhancing efficiencies) initiative aims to drive safer, higher-quality patient care through identifying and reducing low-value practices. AIMS: To determine the Australian Rheumatology Association's (ARA's) 'top 5' list of low-value practices. METHODS: A working group comprising 19 rheumatologists and three trainees compiled a preliminary list. Items were retained if there was strong evidence of low-value and there was high or increasing clinical use and/or increasing cost...
October 28, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/29069539/low-intensity-pulsed-ultrasound-stimulation-for-mandibular-condyle-osteoarthritis-lesions-in-rats
#10
Akemi Kanaguchi Arita, Ikuo Yonemitsu, Yuhei Ikeda, Mutsumi Miyazaki, Takashi Ono
OBJECTIVE: This study evaluated low-intensity pulsed ultrasound effects for temporomandibular joint osteoarthritis in adult rats. MATERIAL AND METHODS: Osteoarthritis-like lesions were induced in 24 adult rats' temporomandibular joints with low-dose mono-iodoacetate injections. The rats were divided into four groups: control and mono-iodoacetate groups, injected with contrast media and mono-iodoacetate, respectively, at 12 weeks and observed until 20 weeks; and low-intensity pulsed ultrasound and mono-iodoacetate + low-intensity pulsed ultrasound groups, injected with contrast media and mono-iodoacetate, respectively, at 12 weeks with low-intensity pulsed ultrasound performed from 16-20 weeks...
October 25, 2017: Oral Diseases
https://www.readbyqxmd.com/read/29065925/ultrasound-verified-inflammation-and-structural-damage-in-patients-with-hereditary-haemochromatosis-related-arthropathy
#11
Christian Dejaco, Andreas Stadlmayr, Christina Duftner, Viktoria Trimmel, Rusmir Husic, Elisabeth Krones, Shahin Zandieh, Emma Husar-Memmer, Gernot Zollner, Josef Hermann, Judith Gretler, Angelika Lackner, Anja Ficjan, Christian Datz, Roland Axman, Jochen Zwerina
BACKGROUND: Chronic arthropathy occurs in approximately two thirds of patients with hereditary haemochromatosis (HH). The aim was to study inflammatory and structural lesions in patients with HH with (HH-A) and without arthropathy (HH-WA) using ultrasonography. METHODS: This was a cross-sectional study of 26 patients with HH-A, 24 with HH-WA and 37 with hand osteoarthritis (HOA). Clinical examination was performed in 68 joints, and we retrieved data on hand function, pain and global disease activity (all using a visual analogue scale (VAS)), morning stiffness and ferritin levels...
October 24, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29016185/clinical-outcomes-of-knee-osteoarthritis-treated-with-an-autologous-protein-solution-injection-a-1-year-pilot-double-blinded-randomized-controlled-trial
#12
Elizaveta Kon, Lars Engebretsen, Peter Verdonk, Stefan Nehrer, Giuseppe Filardo
BACKGROUND: Osteoarthritis (OA) is a debilitating disease resulting in substantial pain and functional limitations. A novel blood derivative has been developed to concentrate both growth factors and antagonists of inflammatory cytokines, with promising preliminary findings in terms of safety profile and clinical improvement. PURPOSE: To investigate if one intra-articular injection of autologous protein solution (APS) can reduce pain and improve function in patients affected by knee OA in a multicenter, randomized, double-blind, saline-controlled study...
October 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28991041/quadriceps-function-and-knee-joint-ultrasonography-following-acl-reconstruction
#13
Derek N Pamukoff, Melissa M Montgomery, Tyler J Moffit, Michael N Vakula
PURPOSE: Individuals with anterior cruciate ligament reconstruction (ACLR) are at greater risk for knee osteoarthritis (OA), partially due to chronic quadriceps dysfunction. Articular cartilage is commonly assessed using magnetic resonance imaging and radiography, but these methods are expensive and lack portability. Ultrasound imaging may provide a cost-effective and portable alternative for imaging the femoral cartilage. The purpose of this study was to compare ultrasonography of the femoral cartilage between the injured and uninjured limbs of individuals with unilateral ACLR, and to examine the association between quadriceps function and ultrasonographic measures of femoral cartilage...
October 3, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28975078/adding-intra-articular-growth-hormone-to-platelet-rich-plasma-under-ultrasound-guidance-in-knee-osteoarthritis-a-comparative-double-blind-clinical-trial
#14
Poupak Rahimzadeh, Farnad Imani, Seyed-Hamid-Reza Faiz, Mahmoud-Reza Alebouyeh, Damoon Azad-Ehyaei, Leila Bahari, Arash Memarian, Kyung-Hoon Kim
INTRODUCTION: Intra-articular injections of platelet rich plasma (PRP) for the treatment of knee osteoarthritis have been shown to reduce pain and improve joint function. The aim of this study is to examine the joint function by adding intra-articular growth hormone to platelet rich plasma. This study was performed on the individuals with knee osteoarthritis and under ultrasound guidance. METHODS: Fifty four patients who were scheduled for ultra-sound guided intra-articular injection were enrolled in the study...
December 2016: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/28970118/effects-of-lateral-wedge-insole-application-on-medial-compartment-knee-osteoarthritis-severity-evaluated-by-ultrasound
#15
Yosuke Ishii, Masataka Deie, Naoto Fujita, Hiroshi Kurumadani, Masakazu Ishikawa, Atsuo Nakamae, Seiju Hayashi, Jiro Hata, Nobuo Adachi, Toru Sunagawa
BACKGROUND: It is known that a lateral wedge insole (LWI) decreases medial loading stress in the knee. Medial meniscus pathology, such as a degenerative tear or a root tear, leading to malfunction and medial meniscus extrusion (MME), is a critical condition that leads to severe osteoarthritis (OA). However, the effect of LWI on MME is still unknown. The objective of this study was to investigate the effect of LWI use on MME in knee OA using ultrasonography. METHODS: Thirty-one knees from 18 patients with knee OA diagnosed radiographically were allocated to the OA group (mean age, 73...
September 29, 2017: Knee
https://www.readbyqxmd.com/read/28969753/rheumatoid-arthritis-masquerading-as-fibromyalgia
#16
Muhammad Armughan Ali, Marium Rehman, Mohammad Saeed
Symptoms of inflammatory arthritis such as rheumatoid arthritis (RA) can overlap with fibromyalgia syndrome (FMS). Moreover, FMS and RAcan coexist. Hence, the diagnosis of low intensity, antibody-negative RAmay present a challenge. Here, we present the case of a middle-aged woman thought to have FMS, osteoarthritis and osteoporosis for 4 years prior to being diagnosed as seronegative RAon musculoskeletal ultrasound (MSKUS). Targeted therapy with etanercept led to a complete clinical response and normalization of previously elevated C-reactive protein...
September 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28965723/high-frequency-ultrasound-imaging-of-tidemark-in-vitro-in-advanced-knee-osteoarthritis
#17
Yan-Ping Huang, Jin Zhong, Jie Chen, Chun-Hoi Yan, Yong-Ping Zheng, Chun-Yi Wen
High-frequency ultrasound imaging has been widely adopted for assessment of the degenerative changes of articular cartilage in osteoarthritis (OA). Yet, there are few reports on investigating its capability to evaluate subchondral bone. Here, we employed high-frequency ultrasound imaging (25 MHz) to examine in vitro the tidemark in cylindrical osteochondral disks (n = 33) harvested from advanced OA knees of humans. We found good correspondence in morphology observed by ultrasound imaging and micro-computed tomography...
September 28, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28947452/a-hospital-based-observational-cohort-study-exploring-pain-and-biomarkers-in-patients-with-hand-osteoarthritis-in-norway-the-nor-hand-protocol
#18
Marthe Gløersen, Elisabeth Mulrooney, Alexander Mathiessen, Hilde Berner Hammer, Barbara Slatkowsky-Christensen, Karwan Faraj, Thore Isaksen, Tuhina Neogi, Tore K Kvien, Karin Magnusson, Ida Kristin Haugen
INTRODUCTION: We have limited knowledge about the underlying disease mechanisms and causes of pain in hand osteoarthritis (OA). Consequently, no disease-modifying drug exists, and more knowledge about the pathogenesis of hand OA is needed, as well as a validation of different outcome measures. Our first aim of this study is to explore the validity of various imaging modalities for the assessment of hand OA. Second, we want to gain a better understanding of the disease processes, with a special focus on pain mechanisms...
September 24, 2017: BMJ Open
https://www.readbyqxmd.com/read/28940031/the-role-of-thermal-balneotherapy-in-the-treatment-of-obese-patient-with-knee-osteoarthritis
#19
Stefano Masiero, Filippo Vittadini, Costanza Ferroni, Anna Bosco, Roberto Serra, Anna Chiara Frigo, Antonio Frizziero
Osteoarthritis (OA) is the most common form of arthritis clinically characterized by joint pain, functional limitation, and reduced quality of life. Several studies have shown a clear link between obesity and higher risk of knee OA. According to the multifactorial OA pathogenesis, the management of this condition requires a multidisciplinary approach. The objective of this study is to evaluate hydrokinesitherapy effects in thermal setting in obese patients with knee OA. Fifty-three patients were assessed for eligibility, of which 33 refused the treatment, while 10 patients dropped out after the enrollment for personal reasons or inability to adhere to the program...
September 22, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28932004/effects-of-pulsed-therapeutic-ultrasound-on-the-treatment-of-people-with-knee-osteoarthritis
#20
Eliana-Isabel Rodríguez-Grande, Jose-Luis Osma-Rueda, Yannely Serrano-Villar, Carolina Ramírez
[Purpose] The aim was to evaluate the effect of therapeutic ultrasound on the pain, joint mobility, muscle strength, physical function, and quality of life of people with knee OA. [Subjects and Methods] One-site, one-arm, before-after study that included people with Grade II or III tibiofemoral osteoarthritis. Ten therapeutic ultrasound sessions (duty cycle=20%, ERA=10 cm(2), BNR=6:1, SATP=2.2 W/cm(2), SATA=0.44 W/cm(2), frequency=1 MHz, time=4 minutes) were applied. Assessments of primary outcome variables: pain intensity and function, and secondary variables: joint mobility, muscle strength and quality of life, were performed at onset and end of therapy; an additional intermediate evaluation was included for the primary variables...
September 2017: Journal of Physical Therapy Science
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