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JOURNAL ARTICLE
Yingying Wan, Wenting Sun, Jiaxi Yang, Haonan Wang, Wenqian Wang, Wanting Ye, Guoliang Cheng, Bing Li, Jianxun Ren, Qiuai Kou
Introduction: Jinteng Qingbi granules (JTQBG), a traditional Chinese medicine formulation, are widely used for the treatment of rheumatoid arthritis (RA) due to their satisfactory therapeutic efficacy. However, the underlying mechanism of action remains unclear. This study aims to investigate the protective effects of JTQBG against RA and elucidates its potential molecular mechanisms. Methods: A collagen-induced arthritis (CIA) rat model was utilized, and JTQBG (1.25, 2.5, 5 g/kg/day) or methotrexate (MTX, 1 mg/kg/week) was orally administered...
2024: Frontiers in Pharmacology
#22
JOURNAL ARTICLE
Marco Di Carlo, Jacopo Di Battista, Edoardo Cipolletta, Tadashi Okano, Riccardo Chiorrini, Gianluca Smerilli, Francesca Bandinelli, Emilio Filippucci, Fausto Salaffi
(1) Background : Rheumatoid arthritis (RA) is a chronic inflammatory joint disease, primarily characterized by pain. A significant proportion of patients report symptoms suggestive of neuropathic pain. The objectives of this study were to investigate the presence of an increased cross-sectional area (CSA) of the palmar digital nerves by ultrasound in patients with active synovitis of the metacarpophalangeal joints and to identify potential predictors of such an increase. (2) Methods : An ultrasound examination of the clinically most affected hand (from the second to the fifth metacarpophalangeal joint) was performed...
March 11, 2024: Journal of Clinical Medicine
#23
JOURNAL ARTICLE
Zouhour Gassara, Afef Feki, Zina Hakim, Samar Ben Djmeaa, Cyrine Abid, Mohamed Hedi Kallel, Hela Fourati, Sofien Baklouti
BACKGROUND: The purpose of this study was to evaluate the prevalence of foot involvement in psoriatic arthritis and to describe its different clinical and radiological features. PATIENTS AND METHODS: We conducted a cross sectional study including 40 patients with psoriatic arthritis over a period of 12 months. Anamnesis, clinical examination of feet, podoscopic examination, X-rays of feet and heels, and ultrasound in B mode and power Doppler mode were done for each patient...
March 21, 2024: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
#24
REVIEW
Aslihan Avanoglu-Guler, Corrado Campochiaro, Giacomo De Luca, Michael Hughes, Abdurrahman Tufan, Lorraine Green, Francesco Del Galdo, Marco Matucci-Cerinic, Lorenzo Dagna
In SSc, dystrophic calcinosis is one of the major clinical manifestations, characterized by the deposition of insoluble calcific substances in tissues, predominantly in the chemical form of calcium hydroxyapatite. Furthermore, calcinosis might lead to compressive neuropathies and severe pain. Current evidence suggests that tissue ischemia and repeated trauma are implicated in the development of calcinosis; however, there are still too many unknown areas that need to be investigated. Detection of calcinosis is commonly performed using X-ray or ultrasound...
March 16, 2024: Seminars in Arthritis and Rheumatism
#25
JOURNAL ARTICLE
Esperanza Naredo, Maria Antonietta D'Agostino, Lene Terslev, Carlos Pineda, M Isabel Miguel, Joan Blasi, George A Bruyn, Marion C Kortekaas, Peter Mandl, Rodina Nestorova, Marcin Szkudlarek, Plamen Todorov, Violeta Vlad, Priscilla Wong, Catherine Bakewell, Emilio Filippucci, Alen Zabotti, Mihaela Micu, Florentin Vreju, Mohamed Mortada, José Alexandre Mendonça, Carlos A Guillen-Astete, Otto Olivas-Vergara, Annamaria Iagnocco, Petra Hanova, Ilaria Tinazzi, Peter V Balint, Sibel Zehra Aydin, David Kane, Helen Keen, Gurjit S Kaeley, Ingrid Möller
OBJECTIVES: The main objective was to generate a GLobal OMERACT Ultrasound DActylitis Score (GLOUDAS) in psoriatic arthritis and to test its reliability. To this end, we assessed the validity, feasibility and applicability of ultrasound assessment of finger entheses to incorporate them into the scoring system. METHODS: The study consisted of a stepwise process. First, in cadaveric specimens, we identified enthesis sites of the fingers by ultrasound and gross anatomy, and then verified presence of entheseal tissue in histological samples...
April 4, 2024: Annals of the Rheumatic Diseases
#26
JOURNAL ARTICLE
Jacqueline Crossman, Hollis Lai, Marianna Kulka, Nadr Jomha, Patrick Flood, Tarek El-Bialy
Juvenile idiopathic arthritis (JIA) is an inflammatory disease that can affect the temporomandibular joint (TMJ) and lower jaw growth. Better treatment options are needed, so this study investigated the effect of low intensity pulsed ultrasound (LIPUS) on TMJ arthritis. Seventy-two 3-week old male Wistar rats were in vivo micro-computed tomography (MicroCT) scanned and divided into 8 groups (n=9). These groups were Group 1 - TMJ arthritis and immediate LIPUS treatment (20 minutes/day, 4 weeks); Group 2 - immediate LIPUS treatment and no TMJ arthritis; Group 3 - TMJ arthritis and no LIPUS; Group 4 - no TMJ arthritis and no LIPUS; Group 5 - TMJ arthritis and LIPUS treatment with a delayed start by 4 weeks; Group 6 - delayed LIPUS and no TMJ arthritis; Group 7 - TMJ arthritis and no (delayed) LIPUS; and Group 8 - no TMJ arthritis and no (delayed) LIPUS...
March 22, 2024: Tissue Engineering. Part A
#27
REVIEW
A L Ribeiro, L Eder
PURPOSE OF REVIEW: This review summarizes the literature about the transition from psoriasis to psoriatic arthritis (PsA), focusing on musculoskeletal ultrasound (MSUS) for detecting subclinical inflammation and its role in diagnosis and triage of high-risk patients. RECENT FINDINGS: MSUS effectively detects subclinical musculoskeletal inflammation in patients with psoriasis; however, some of these lesions are non-specific and can be found in healthy individuals...
March 21, 2024: Current Rheumatology Reports
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JOURNAL ARTICLE
Khaldoun Chaabo, Estee Chan, Toby Garrood, Zoe Rutter-Locher, Alex Vincent, James Galloway, Sam Norton, Bruce W Kirkham
INTRODUCTION: Despite better therapies and strategies, many people with rheumatoid arthritis (RA) have persistent pain, often from abnormal pain processing, now termed nociplastic pain. However, RA patients with fibromyalgia (FM), a central nociplastic pain syndrome, also have power doppler ultrasound (PDUS+) joint inflammation. To understand the complex causes of pain, we performed clinical examination and patient-reported outcome measures (PROMs) plus comprehensive PDUS evaluation not previously combined...
March 19, 2024: RMD Open
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REVIEW
Fumiaki Nonaka, Shoichi Fukui, Tohru Michitsuji, Yushiro Endo, Ayako Nishino, Toshimasa Shimizu, Masataka Umeda, Remi Sumiyoshi, Tomohiro Koga, Naoki Iwamoto, Tomoki Origuchi, Yukitaka Ueki, Nobutaka Eiraku, Takahisa Suzuki, Akitomo Okada, Naoki Matsuoka, Hirokazu Takaoka, Hiroaki Hamada, Tomomi Tsuru, Yojiro Arinobu, Toshihiko Hidaka, Keita Fujikawa, Tamami Yoshitama, Yoshifumi Tada, Hideo Ohtsubo, Jun Ishizaki, Tomoyuki Asano, Takahiro Maeda, Atsushi Kawakami, Shin-Ya Kawashiri
OBJECTIVE: Glucocorticoids are effective in treating rheumatoid arthritis (RA) when used appropriately considering the balance of the risks and benefits, especially at low doses. We aimed to evaluate the response of biologic and targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) in patients having already been treated with glucocorticoids. METHODS: We reviewed RA patients treated with b/tsDMARDs in a prospective multicenter ultrasound cohort study...
March 2024: International Journal of Rheumatic Diseases
#30
REVIEW
Daniel Octavian Costache, Horia Blejan, Damian Lucian Cojocaru, Georgiana Alexandra Ioniță, Marcela Poenaru, Maria Magdalena Constantin, Andrei Cătălin Costache, Constantin Căruntu, Daniel Vasile Balaban, Raluca Simona Costache
Psoriasis is a chronic, immune-mediated, inflammatory disease that has a major impact on patients' quality of life. Common psoriasis-associated comorbidities include cardiovascular diseases, psoriatic arthritis, inflammatory bowel syndromes, type-2 diabetes, and metabolic syndrome. Nonalcoholic fatty liver disease (NAFLD) is affecting a substantial portion of the population and is closely linked with psoriasis. The interplay involves low-grade chronic inflammation, insulin resistance, and genetic factors. The review presents the pathophysiological connections between psoriasis and nonalcoholic fatty liver disease, emphasizing the role of cytokines, adipokines, and inflammatory cascades...
February 24, 2024: International Journal of Molecular Sciences
#31
JOURNAL ARTICLE
Rubén Queiro, Estefanía Pardo
No abstract text is available yet for this article.
March 11, 2024: Rheumatology
#32
JOURNAL ARTICLE
Asma Marzouk, Rania Mezzi, Saida Zelfani, Nour Jelaila, Saad Ayeb, Asma Bouaziz
INTRODUCTION: Psoriasis is a common chronic inflammatory condition, often beginning in childhood in approximately one-third of cases. It can be associated with various other autoimmune diseases such as rheumatoid arthritis, celiac disease, and thyroid disorders. However, its co-occurrence with Van Wyk Grumbach syndrome has not been described in the pediatric population. This syndrome, resulting from untreated hypothyroidism, is characterized by early puberty and ovarian cysts. OBSERVATION: A 15-year-old adolescent with a diagnosis of psoriasis since the age of 9 presented with chronic constipation and headaches...
October 5, 2023: La Tunisie Médicale
#33
Cherie S Zhi, Julia R Kesselhaut, Swamy R Venuturupalli, Ami Ben-Artzi
We report a case of a 74-year-old male who presented with typical clinical features of rheumatoid arthritis (RA), as well as elevated markers of inflammation. However, the patient did not respond to multiple RA treatments, and an ultrasound-guided synovial biopsy (UGSB) of the right wrist was performed, which established the diagnosis of amyloidosis. A variety of inflammatory conditions sometimes get misdiagnosed as seronegative RA due to similarities in clinical presentation. This case report highlights the importance of a thorough workup in patients who appear to have seronegative RA...
February 2024: Curēus
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JOURNAL ARTICLE
Alexandra Cîrciumaru, Yogan Kisten, Monika Hansson, Linda Mathsson-Alm, Vijay Joshua, Heidi Wähämaa, Malena Loberg Haarhaus, Joakim Lindqvist, Leonid Padyukov, Sergiu-Bogdan Catrina, Guozhong Fei, Nancy Vivar, Hamed Rezaei, Erik Af Klint, Aleksandra Antovic, Bence Réthi, Anca I Catrina, Aase Hensvold
OBJECTIVE: Individuals positive for anti-cyclic-peptide-antibodies (anti-CCP) and musculoskeletal complaints (MSK-C) are at risk for developing rheumatoid arthritis (RA). In this study we aimed to investigate factors involved in arthritis progression. METHODS: Anti-CCP2-positive individuals with MSK-C referred to a rheumatologist were recruited. Individuals lacked arthritis at clinical and ultrasound examination and were followed for ≥three years or until clinical arthritis diagnosis...
March 8, 2024: Rheumatology
#35
JOURNAL ARTICLE
Sherif M Zaki, Dina S El Karsh, Tuleen M Faden, Leen T Almghamsi, Joud O Fathaldin, Omar A Alhazmi
REVIEW: A common chronic health problem among Saudi Arabians is diabetes mellitus (DM). One of the most serious complications of diabetes is diabetic foot (DMF). AIM: The objective of this study was to identify the most common complications that develop among patients with DMF. In addition, we conducted a demographic analysis of chronic diabetic complications related to DMF. MATERIAL AND METHODS: The study involved 100 DMF attending the Jeddah clinic of Dr Soliman Fakeeh Hospital...
February 2024: Curēus
#36
Koh Kitagawa, Masafumi Oyama, Shohei Asada, Shinya Sato, Tatsuya Nakatani, Naoki Nishimura, Yuka Mui, Jun-Ichi Hanatani, Maiko Takeda, Hitoshi Yoshiji
A 73-year-old woman with a history of rheumatoid arthritis treated with methotrexate (MTX) for the last 10 years was referred to our hospital for a pancreatic tumor examination. Contrast-enhanced abdominal computed tomography revealed a 20-mm-diameter hypovascular tumor in the pancreatic tail. A hypoechoic mass with heterogeneous internal echo was found on an endoscopic ultrasound (EUS). An EUS-guided fine-needle biopsy (EUS-FNB) was performed with a 22-gauge Franseen-tip needle. Histologic examination of EUS-FNB specimens from the pancreatic tumor revealed the proliferation of atypical spindle cells...
April 2024: DEN Open
#37
JOURNAL ARTICLE
Eiman Soliman, Sarah Ohrndorf, Magdy Zehairy, Khaled Matrawy, Abeer Alhadidy, Abeer Abdelati
BACKGROUND: First-degree relatives (FDRs) of rheumatoid arthritis (RA) patients are known to have increased risk of developing the disease. The detection of altered bone metabolism in FDRs could be a predictor of the disease. Musculoskeletal ultrasound (MSUS) is known for its ability to detect subclinical joint inflammation in RA, but changes in FDRs are not yet described. We aimed to study serum Osteopontin (OPN) and Osteoprotegerin (OPG) levels in FDRs of RA patients as markers of altered bone metabolism in relation to clinical, laboratory and musculoskeletal ultrasound (MSUS) findings...
March 5, 2024: BMC Musculoskeletal Disorders
#38
Marco Aurelio Ramírez Huaranga, David Velasco Sánchez, Luis Ángel Calvo Pascual, David Castro Corredor, María Dolores Mínguez Sánchez, Verónica Salas Manzanedo, Eva Revuelta Evrard, Rocío Arenal López, Joaquín Anino Fernández, Marina González Peñas, Lourdes Martin de la Sierra López, Laura María Jiménez Rodríguez, Alberto López Menchero Mora, Marcos Paulino Huertas
UNLABELLED: Rheumatoid Arthritis (RA) has a mortality rate 1,3 to 3 times higher than the general population, with cardiovascular mortality accounting for 40-50% of cases. Currently, cardiovascular disease is considered an extraarticular manifestation of RA (OR: 1,5-4,0). Ultrasound measurement of the intima-media thickness (IMT) of the common carotid artery and the presence of atherosclerotic plaques (AP) is a non-invasive method and a surrogate marker of subclinical arteriosclerosis...
March 4, 2024: Reumatología clinica
#39
JOURNAL ARTICLE
Andrea Di Matteo, Gianluca Smerilli, Stefano Di Donato, An Ran Liu, Andrea Becciolini, Federica Camarda, Tomas Cazenave, Edoardo Cipolletta, Davide Corradini, Juan José de Agustín, Giulia Maria Destro Castaniti, Eleonora Di Donato, Luca Di Geso, Emine Duran, Bayram Farisogullari, Marco Fornaro, Francesca Francioso, Pamela Giorgis, Amelia Granel, Cristina Hernández-Díaz, Rudolf Horvath, Jana Hurnakova, Diogo Jesus, Omer Karadag, Ling Li, Josefina Marin, María Victoria Martire, Xabier Michelena, Erica Moscioni, Laura Muntean, Matteo Piga, Marcos Rosemffet, João Rovisco, Didem Sahin, Fausto Salaffi, Liliana Saraiva, Crescenzio Scioscia, Maria-Magdalena Tamas, Shun Tanimura, Aliki Venetsanopoulou, Lucio Ventura-Rios, Orlando Villota, Catalina Villota-Eraso, Paraskevi V Voulgari, Gentiana Vukatana, Johana Zacariaz Hereter, Helena Marzo-Ortega, Walter Grassi, Emilio Filippucci
OBJECTIVES: To assess, in spondyloarthritis (SpA), the discriminative value of the Outcome Measures in Rheumatology (OMERACT) ultrasound lesions of enthesitis and their associations with clinical features in this population. METHODS: In this multicentre study involving 20 rheumatology centres, clinical and ultrasound examinations of the lower limb large entheses were performed in 413 patients with SpA (axial SpA and psoriatic arthritis) and 282 disease controls (osteoarthritis and fibromyalgia)...
March 5, 2024: Annals of the Rheumatic Diseases
#40
REVIEW
Kevin D Deane
PURPOSE OF REVIEW: This review discusses updates in the prediction and prevention of future rheumatoid arthritis (RA). RECENT FINDINGS: In individuals with musculoskeletal symptoms and elevated antibodies to citrullinated proteins (ACPA) without clinical inflammatory arthritis (IA), a 'simple' score has a positive predictive value (PPV) of ∼28% for clinical IA/RA within 1 year, and a comprehensive score (including ultrasound) has a PPV of ∼71% for clinical RA within 5 years...
May 1, 2024: Current Opinion in Rheumatology
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