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https://www.readbyqxmd.com/read/28919914/agreement-of-clinical-examination-and-ultrasound-methods-for-detection-of-joints-involvements-in-rheumatoid-arthritis
#1
Hadi Karimzadeh, Ramin Rafiei, Zahra Sayedbonakdar, Mehdi Karami
BACKGROUND: Rheumatoid arthritis is a chronic autoimmune disease characterized by synovial tissue inflammation and destruction of articular components which if not controlled properly, can cause disability in patients. For this reason, evaluation of disease activity and its control is very important. In recent years using sonography is promising for the evaluation of disease activity. This study aimed to compare "clinical examination" and "ultrasonography" methods in the detection of disease activity in patients with rheumatoid arthritis...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/28915847/absence-of-ultrasound-inflammation-in-patients-presenting-with-arthralgia-rules-out-the-development-of-arthritis
#2
Myrthe van der Ven, M van der Veer-Meerkerk, D F Ten Cate, N Rasappu, M R Kok, D Csakvari, J M W Hazes, A H Gerards, J J Luime
BACKGROUND: To decrease the burden of disease of rheumatoid arthritis (RA), patients at risk for RA need to be identified as early as possible, preferably when no clinically apparent synovitis can be detected. Up to now, it has been fairly difficult to identify those patients with arthralgia who develop inflammatory arthritis (IA), but recent studies using ultrasound (US) suggest that earlier detection is possible. We aimed to identify patients with arthralgia developing IA within 1 year using US to detect subclinical synovitis at first consultation...
September 15, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28893220/the-added-value-of-musculoskeletal-ultrasound-to-clinical-evaluation-in-the-treatment-decision-of-rheumatoid-arthritis-outpatients-physician-experience-matters
#3
C Sifuentes-Cantú, I Contreras-Yáñez, L Saldarriaga, A C Lozada, M Gutiérrez, V Pascual-Ramos
BACKGROUND: Musculoskeletal ultrasound improves the accuracy of detecting the level of disease activity (DA) in RA patients, although its impact on the final treatment decision in a real clinical setting is uncertain. The objectives were to define the percentage of clinical scenarios from an ongoing cohort of RA outpatients in which the German Ultrasound Score on 7 joints (GUS-7) impacted the treatment and to explore if the impact differed between a senior rheumatologist (SR) vs. a trainee (TR)...
September 11, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28889184/cartilage-oligomeric-matrix-protein-comp-in-rheumatoid-arthritis-and-its-correlation-with-sonographic-knee-cartilage-thickness-and-disease-activity
#4
Rajalingham Sakthiswary, Shamala Rajalingam, Heselynn Hussein, Radhika Sridharan, Abdul Wahab Asrul
The aim of the study is to investigate the correlation of serum cartilage oligomeric matrix protein (COMP) levels with articular cartilage damage based on sonographic knee cartilage thickness (KCT) and disease activity in rheumatoid arthritis (RA). A total of 61 RA patients and 27 healthy controls were recruited in this study. Serum samples were obtained from all subjects to determine the serum COMP levels. All subjects had bilateral ultrasound scan of their knees. The KCT was based on the mean of measurements at three sites: the medial condyle, lateral condyle and intercondylar notch...
September 9, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28879054/achilles-enthesitis-defined-by-ultrasound-is-not-associated-with-clinical-enthesitis-in-patients-with-psoriatic-arthritis
#5
Brigitte Michelsen, Andreas P Diamantopoulos, Dag Magnar Soldal, Hilde Berner Hammer, Arthur Kavanaugh, Glenn Haugeberg
OBJECTIVE: To compare clinical and ultrasonographic (US) evaluation of Achilles enthesitis in patients with psoriatic arthritis (PsA). METHODS: The Achilles insertion of outpatients with PsA was examined by clinical assessment of tenderness and US evaluation of (1) inflammatory activity (defined as the presence of power Doppler signal, tendon thickening and/or hypoechogenicity) and (2) structural damage (defined as the presence of erosions, calcifications and/or enthesophytes)...
2017: RMD Open
https://www.readbyqxmd.com/read/28877097/application-of-transcranial-color-doppler-ultrasonography-for-assessing-middle-cerebral-arteries-in-rheumatoid-arthritis
#6
Qiuyue Chen, Shilin Li, Guorong Lv, Yanchun Zhao
To assess the role of ultrasonography for assessing middle cerebral arteries (MCAs) in rheumatoid arthritis (RA). Middle cerebral arteries of 32 RA patients and 32 healthy volunteers were examined by ultrasonography. Peak systolic blood flow velocity (PSV), end-diastolic velocity, and resistance index (RI) of MCA were measured using Doppler ultrasound. Results were expressed as mean ± SD. No significant difference in peak systolic velocity was obtained between RA patients (52.44 ± 19.56 cm/s) and healthy volunteers (51...
September 4, 2017: Ultrasound Quarterly
https://www.readbyqxmd.com/read/28871338/comparison-of-the-effectiveness-on-intra-articular-and-subcutaneous-tnf-inhibitor-in-rheumatoid-arthritis-patients
#7
Fangze Zhang, Cuili Ma
The objective of this study is to evaluate the efficacy of single intra-articular (IA) injection of tumor necrosis factor α (TNFα) inhibitor in knee joints comparing with subcutaneous injection in rheumatoid arthritis (RA) patients. Forty-eight RA patients with 73 knee arthritis were divided into three groups, group A: received a single injection of TNF inhibitor into knee joints; group B: received regular subcutaneous injection; and group C: received both of the regimen as groups A and B. Ultrasound, erythrocyte sedimentation rate, C-reactive protein (CRP), patients' global visual analogue scale (VAS), and 28-joint Disease Activity Score (DAS28) were collected pre- and post-therapy 4 weeks...
September 4, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28870177/will-chinese-external-therapy-with-compound-tripterygium-wilfordii-hook-f-gel-safely-control-disease-activity-in-patients-with-rheumatoid-arthritis-design-of-a-double-blinded-randomized-controlled-trial
#8
RANDOMIZED CONTROLLED TRIAL
Quan Jiang, Xiao-Po Tang, Xian-Chun Chen, Hong Xiao, Ping Liu, Juan Jiao
BACKGROUND: Chinese external therapy (CET) is a topical application with mainly Chinese herb medicine therapy with thousands of years of historical implications and is a clinical routine that is commonly used for relieving joint-related symptoms in patients with arthritis in Chinese hospitals. However, there is a paucity of modern medical evidence to support its effectiveness and safety. Thus, we propose to implement a randomized, double-blinded, placebo-controlled clinical trial in patients with rheumatoid arthritis (RA) using, as the experimental intervention, topical application of a hospital-compounded gel preparation of Tripterygium wilfordii Hook F (TwHF)...
September 5, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28864556/massive-splenomegaly-due-to-concurrent-primary-epstein-barr-virus-and-cytomegalovirus-infection-in-a-patient-on-adalimumab
#9
Barathy Rani Ramasamy, Patrick Charles, Douglas Johnson, Albert Frauman
A 32-year-old man who was receiving adalimumab for seronegative rheumatoid arthritis presented with a 4-week history of fever, night sweats, fatigue, myalgias and diarrhoea. On examination, he had obvious splenomegaly but no lymphadenopathy or pharyngitis. Full blood count revealed mild neutropenia and significant lymphocytosis, with a blood film showing atypical lymphocytes. Liver function tests were mildly deranged with a mixed hepatitic and obstructive pattern. Ultrasound confirmed massive splenomegaly with a span of 21 cm in the long axis...
September 1, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28845495/a-novel-ultrasound-based-technique-to-establish-a-correlation-between-disease-activity-and-local-carotid-stiffness-parameters-in-rheumatoid-arthritis
#10
Ayşe Nur Şirin Özcan, Abdullah Nabi Aslan, Özlem Ünal, Karabekir Ercan, Orhan Küçükşahin
AIM: Cardiovascular (CV) disease is the reason for most mortality cases in RA and cannot be explained only by the presence of traditional CV risk factors. In this study, we aimed to investigate the relationship between local carotid stiffness (CS) parameters measured by a novel ultrasound method and inflammatory disease activity in rheumatoid arthritis (RA) patients. Material and methods: The study was conducted with 70 RA patients and 35 control subjects. According to their disease activity score (DAS-28), the RA patients were classified into active RA (n = 36; DAS-28 > 3...
May 10, 2017: Medical Ultrasonography
https://www.readbyqxmd.com/read/28834302/mtx-use-in-japanese-patients-with-rheumatoid-arthritis
#11
Ayako Hirata, Takehisa Ogura, Norihide Hayashi, Sayaka Takenaka, Hideki Ito, Kennosuke Mizushina, Yuki Fujisawa, Naoko Yamashita, Sumie Nakahashi, Munetsugu Imamura, Rie Kujime, Hideto Kameda
We appreciate the letter from Dr. Carlos Antonio Moura and Dr. Carlos Geraldo Moura for their interest in our article [1]. As they noticed, that study was intended to evaluate the concordance of patient-reported joint symptoms, physician-examined arthritic signs, and ultrasound-detected synovitis in rheumatoid arthritis (RA), but not to evaluate the use of MTX. Although we described the median and range of RA duration (months) as 31 and 0-608, we should have clearly stated that 11 of 50 patients enrolled in that study were treatment-naïve...
August 22, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28832684/relationship-between-serum-calprotectin-s100a8-9-and-clinical-laboratory-and-ultrasound-parameters-of-disease-activity-in-rheumatoid-arthritis-a-large-cohort-study
#12
Jana Hurnakova, Hana Hulejova, Jakub Zavada, Petra Hanova, Martin Komarc, Herman Mann, Martin Klein, Olga Sleglova, Marta Olejarova, Sarka Forejtova, Olga Ruzickova, Jiri Vencovsky, Karel Pavelka, Ladislav Senolt
BACKGROUND: Calprotectin may be a sensitive biomarker of rheumatoid arthritis (RA) disease activity. OBJECTIVES: In the current study, we investigated whether calprotectin is a better biomarker than CRP for predicting clinical activity and ultrasound parameters in patients with RA. METHODS: A total of 160 patients with RA underwent clinical (swollen joint count-SJC, tender joint count-TJC, Disease Activity Score-DAS28, Clinical Disease Activity Index-CDAI, and simplified Disease Activity Index-SDAI) and ultrasound (German US7) examination...
2017: PloS One
https://www.readbyqxmd.com/read/28831575/a-simplified-and-validated-ultrasound-scoring-system-to-evaluate-synovitis-of-bilateral-wrists-and-hands-in-patients-with-rheumatoid-arthritis
#13
Xiaoying Sun, Xuerong Deng, Yan Geng, Lanlan Ji, Wenhui Xie, Xiaohui Zhang, Zhuoli Zhang
The objective of this study was to develop and validate an optimal simplified combination of joints for ultrasonographic assessment of synovitis in wrists and hands in patients with rheumatoid arthritis (RA). Twenty-two joints, including bilateral wrists, all proximal interphalangeal (PIP), and metacarpophalangeal (MCP) joints, were evaluated by grey-scale (GS) and power Doppler (PD) ultrasound using semi-quantitative scoring systems in 705 RA patients. Candidate joint sets were then selected by multiple linear regression analysis and the optimal candidate set was eventually validated in 235 RA patients...
August 22, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28822791/acute-unilateral-hip-pain-in-fibrodysplasia-ossificans-progressiva-fop
#14
Frederick S Kaplan, Mona Al Mukaddam, Robert J Pignolo
BACKGROUND: Flare-ups of the hips are among the most feared and disabling complications of fibrodysplasia ossificans progressiva (FOP) and are poorly understood. In order to better understand the nature of hip flare-ups in FOP, we evaluated 25 consecutive individuals with classic FOP (14 males, 11 females; 3-56years old, median age, 17years old) who presented with acute unilateral hip pain. RESULTS: All 25 individuals were suspected of having a flare-up of the hip based on clinical history and a favorable response to a four day course of high-dose oral prednisone...
August 16, 2017: Bone
https://www.readbyqxmd.com/read/28814431/calprotectin-as-a-marker-of-inflammation-in-patients-with-early-rheumatoid-arthritis
#15
Maria Karolina Jonsson, Nina Paulshus Sundlisæter, Hilde Haugedal Nordal, Hilde Berner Hammer, Anna-Birgitte Aga, Inge Christoffer Olsen, Karl Albert Brokstad, Désirée van der Heijde, Tore K Kvien, Bjørg-Tilde Svanes Fevang, Siri Lillegraven, Espen A Haavardsholm
OBJECTIVES: Calprotectin is an inflammatory marker of interest in rheumatoid arthritis (RA). We evaluated whether the level of calprotectin was associated with disease activity, and if it was predictive of treatment response and radiographic progression in patients with early RA. METHODS: Plasma from disease-modifying antirheumatic drug (DMARD)-naïve patients with RA fulfilling 2010 American College of Rheumatology/European League Against Rheumatism classification criteria with symptom duration <2 years was analysed for calprotectin at baseline, and after 1, 3 and 12 months...
August 16, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28805018/pain-catastrophizing-is-strongly-associated-with-subjective-outcomes-but-not-with-inflammatory-assessments-in-rheumatoid-arthritis-patients
#16
Hilde B Hammer, Till Uhlig, Tore K Kvien, Jon Lampa
OBJECTIVES: Pain catastrophizing is conceptualized as a negative cognitive-affective response to anticipated or actual pain and has been associated with important pain-related outcomes. The objective of this prospective study of established rheumatoid arthritis (RA) patients was to explore how pain catastrophizing was related to patient-reported outcomes (PROs), composite scores and assessments of inflammatory activity. METHODS: RA patients starting bDMARD were examined at baseline and after 1, 2, 3, 6 and 12 months with PROs (joint pain/patient's global VAS, MHAQ, RAID score), clinical and laboratory assessments (tender/swollen joint count, assessor's global VAS, ESR/CRP), ultrasound (US) (grey scale/power Doppler of 36 joints and 4 tendons) and pain catastrophizing...
August 13, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28802761/ultrasound-versus-magnetic-resonance-imaging-of-the-temporomandibular-joint-in-juvenile-idiopathic-arthritis-a-systematic-review
#17
REVIEW
B L Hechler, J A Phero, H Van Mater, N S Matthews
A systematic review of published articles on ultrasound (US) and magnetic resonance imaging (MRI) of the temporomandibular joint (TMJ) in juvenile idiopathic arthritis (JIA) was performed to answer the question "What is the sensitivity and specificity of US as compared to MRI in diagnosing acute and chronic joint changes in patients with JIA?" The most recent evidence was sought in published articles via a search of the PubMed, Ovid, and Embase databases. Article appraisal was performed by two reviewers. Nineteen articles reporting prospective or ambispective studies comparing US to MRI in TMJ imaging were found...
August 9, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28779958/efficacy-of-indocyanine-green-mediated-sonodynamic-therapy-on-rheumatoid-arthritis-fibroblast-like-synoviocytes
#18
Qin Tang, Shufang Chang, Zhonghua Tian, Jiangchuan Sun, Lan Hao, Zhigang Wang, Shenyin Zhu
Sonodynamic therapy (SDT) has become a new therapeutic method because of its activation of certain sensitizers by ultrasound. Some studies have reported that indocyanine green (ICG) has the characteristics of a sonosensitizer and favorable fluorescence imaging in synovitis of early inflammatory arthritis. In this study, we aimed to investigate the cytotoxic effect of ICG-mediated SDT on MH7A cells in vitro and the potential mechanisms involved. ICG was found to be taken up mainly in cytoplasm, with maximal uptake in 4 h...
August 2, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28774458/ultrasound-in-arthritis
#19
REVIEW
Iwona Sudoł-Szopińska, Claudia Schueller-Weidekamm, Athena Plagou, James Teh
Ultrasound is currently performed in everyday rheumatologic practice. It is used for early diagnosis, to monitor treatment results, and to diagnose remission. The spectrum of pathologies seen in arthritis with ultrasound includes early inflammatory features and associated complications. This article discusses the spectrum of ultrasound features of arthritides seen in rheumatoid arthritis and other connective tissue diseases in adults, such as Sjögren syndrome, lupus erythematosus, dermatomyositis, polymyositis, and juvenile idiopathic arthritis...
September 2017: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/28768630/back-to-the-future-forget-ultrasound-and-focus-on-clinical-assessment-in-rheumatoid-arthritis-management
#20
EDITORIAL
Roberto Caporali, Josef S Smolen
Ultrasound (US) unquestionably improves many aspects of rheumatoid arthritis (RA) diagnosis and management, but no consensus has been reached regarding the optimal US methodology that should be used, and high levels of standardisation have not yet been attained. Current evidence from two randomised controlled trials does not support the US in directing treatment decisions. A return to the endorsement of clinical assessment and the adoption of T2T strategies aiming at ACR/EULAR remission still represent the standard of care for RA and should be pursued through appropriate educational programmes...
August 2, 2017: Annals of the Rheumatic Diseases
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