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https://www.readbyqxmd.com/read/29787569/association-between-il-6-production-in-synovial-explants-from-rheumatoid-arthritis-patients-and-clinical-and-imaging-response-to-biologic-treatment-a-pilot-study
#1
Martin Andersen, Mikael Boesen, Karen Ellegaard, Kalle Söderström, Niels H Søe, Pieter Spee, Ulrik G W Mørch, Søren Torp-Pedersen, Else M Bartels, Bente Danneskiold-Samsøe, Lars Karlsson, Henning Bliddal
INTRODUCTION: The need for biomarkers which can predict disease course and treatment response in rheumatoid arthritis (RA) is evident. We explored whether clinical and imaging responses to biologic disease modifying anti-rheumatic drug treatment (bDMARD) were associated with the individual's mediator production in explants obtained at baseline. METHODS: RA Patients were evaluated by disease activity score 28 joint C-reactive protein (DAS 28-)), colour Doppler ultrasound (CDUS) and 3 Tesla RA magnetic resonance imaging scores (RAMRIS)...
2018: PloS One
https://www.readbyqxmd.com/read/29773450/acromioclavicular-joint-septic-arthritis-in-an-immunocompetent-child-a-case-report
#2
Saurabh Dutt, Jeetendra Lodhi, Vinod Kumar, Abhishek Kashyap
Septic arthritis of acromioclavicular (AC) joint is a rare entity. It is generally seen in patients who are immunocompromised. Only 15 cases have been reported till now, with only one case series of 6 patients. We report a case of septic arthritis of AC joint in an immunocompetent child. A 9 years old girl presented with history of pain in left shoulder for 4 days associated with fever. No history suggestive of any immunocompromised state was complained. On local examination, a swelling of around 3 cm in diameter was found over left AC joint region with raised local temperature, tenderness on palpation and positive response in fluctuation test...
March 23, 2018: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/29766250/juvenile-idiopathic-arthritis-the-role-of-imaging-from-a-rheumatologist-s-perspective
#3
REVIEW
Clara Malattia, Nikolay Tzaribachev, J Merlijn van den Berg, Silvia Magni-Manzoni
Alongside recent advances in treatment strategies for juvenile idiopathic arthritis (JIA), paediatric rheumatologists have taken increasing interest in the use of imaging. Magnetic resonance imaging (MRI) and musculoskeletal ultrasound, by providing more detailed information on disease activity than clinical examination and conventional radiography (CR), have become helpful diagnostic and managerial tools. The growing skeleton, however, with changing appearances over time, is still challenging in the establishment of valid scoring systems for pathological changes...
June 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29766248/imaging-of-the-knee-in-juvenile-idiopathic-arthritis
#4
REVIEW
Robert Hemke, Nikolay Tzaribachev, Anouk M Barendregt, J Merlijn van den Berg, Andrea S Doria, Mario Maas
In juvenile idiopathic arthritis (JIA), imaging is increasingly used in clinical practice. In this paper we discuss imaging of the knee, the clinically most commonly affected joint in JIA. In the last decade, a number of important steps have been made in the development of imaging outcome measures in children with JIA knee involvement. Ultrasound is undergoing a fast validation process, which should be accomplished within the next few years. The validation processes of MRI as an imaging biomarker for clinical trials in the JIA knee are at an advanced stage, with important data available on the feasibility, reliability and validity of the Juvenile Arthritis MRI Scoring system...
June 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29754519/the-role-of-imaging-in-early-diagnosis-and-prevention-of-joint-damage-in-inflammatory-arthritis
#5
Jiang Yue, Dongze Wu, Lai-Shan Tam
Inflammatory arthritis is characterized by chronic inflammation in the synovium, associated with degradation of cartilage and erosion of juxta-articular bone. The bone loss and joint destruction mediated by aberrant immunological responses resulting in proinflammatory cytokine release and various immune cell activation are known as osteoimmunology. Areas covered: A structured literature search including Medline and PubMed, Cochrane meta-analyses and abstracts of international congresses was performed to review joint damage in inflammatory arthritis in terms of pathogenesis, novel imaging assessment and prevention...
May 13, 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29742922/diagnostic-accuracy-of-simplified-ultrasound-hand-examination-protocols-for-detection-of-inflammation-and-disease-burden-in-patients-with-rheumatoid-arthritis
#6
Priyanka Sivakumaran, Sidra Hussain, Laura Attipoe, Coziana Ciurtin
Background There is no consensus regarding the minimum number of joints that should be included in an ultrasound (US) scoring system to reliably assess for disease activity in rheumatoid arthritis (RA). Purpose To assess whether simplified US protocols for hand examination are as informative as the examination of 22 joints in patients with RA, and to correlate the US parameters with disease activity (DAS-28). Material and Methods This is a cross-sectional study of 224 RA patients stratified based on their DAS-28 scores and assessed using eight preselected US examination protocols, including 22, 18, 16, 14, ten, eight, and two different combinations of four joints, respectively...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29721694/current-status-of-ultrasound-and-dual-energy-computed-tomography-in-the-evaluation-of-gout
#7
REVIEW
Hillary W Garner, Daniel E Wessell
Gout is the most common inflammatory arthritis and is increasing in relevance due to its rising prevalence and incidence. Dual-energy CT (DECT) and ultrasound (US) are the most frequently used imaging modalities for the diagnosis of gout and for the follow-up of patients receiving therapy. Although DECT has the highest diagnostic accuracy for gout and shows consistently excellent reader agreement in the assessment of urate deposition change after therapy, US also performs well and remains just as important an imaging tool in these realms due to its practical advantages in cost, availability, and safety...
May 2, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29712616/what-is-the-added-value-of-ultrasound-joint-examination-for-monitoring-synovitis-in-rheumatoid-arthritis-and-can-it-be-used-to-guide-treatment-decisions-a-systematic-review-and-cost-effectiveness-analysis
#8
Emma Simpson, Emma Hock, Matt Stevenson, Ruth Wong, Naila Dracup, Allan Wailoo, Philip Conaghan, Cristina Estrach, Christopher Edwards, Richard Wakefield
BACKGROUND: Synovitis (inflamed joint synovial lining) in rheumatoid arthritis (RA) can be assessed by clinical examination (CE) or ultrasound (US). OBJECTIVE: To investigate the added value of US, compared with CE alone, in RA synovitis in terms of clinical effectiveness and cost-effectiveness. DATA SOURCES: Electronic databases including MEDLINE, EMBASE and the Cochrane databases were searched from inception to October 2015. REVIEW METHODS: A systematic review sought RA studies that compared additional US with CE...
April 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29706002/-subclinical-enthesopathy-of-at-least-one-extensor-digitorum-tendon-is-highly-prevalent-and-associated-with-clinical-and-ultrasound-alterations-of-the-adjacent-finger-nails-in-patients-with-psoriatic-disease
#9
P Moya Alvarado, E Roé Crespo, F Z Muñoz-Garza, A López-Ferrer, A Laiz Alonso, E Vilarrassa Rull, J Casademont, L Puig Sanz
BACKGROUND: Nail psoriasis disease is associated with an increased probability of psoriatic arthritis and its clinical signs may have different correlates with the pathogenesis of adjacent bone destruction and have different prognostic value. Recent publications about psoriasis and nail psoriatic disease describe different ultrasonographic findings but the relationship between these ungueal alterations measured by ultrasonography and the presence of enthesopathy of the extensor digitorum has yet to be discovered...
April 28, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29703511/validation-of-musculoskeletal-ultrasound-in-the-assessment-of-experimental-gout-synovitis
#10
Esperanza Naredo, Juan Pablo Medina, Sandra Pérez-Baos, Aranzazu Mediero, Gabriel Herrero-Beaumont, Raquel Largo
The objective of this study was to validate musculoskeletal ultrasound (US) in a rabbit model of acute gout. Acute gout was induced by intra-articular injection of monosodium urate (MSU) crystals in 10 rabbits; the 3 controls received vehicle. Rabbit knees were assessed by B-mode and power Doppler (PD) US 24 and 72 h after injections. After 72 h, all rabbits were euthanized. US discriminated between the MSU-injected and control groups with respect to the different inflammatory findings at both at 24 and 72 h and for MSU crystal-related findings after 24 h of injection...
April 24, 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29702022/acute-gouty-knee-arthritis-ultrasound-findings-compared-with-dual-energy-ct-findings
#11
S Strobl, E J Halpern, M Abd Ellah, C Kremser, J Gruber, R Bellmann-Weiler, C Deml, A Schmalzl, S Rauch, A S Klauser
OBJECTIVE: The purpose of this study was to compare findings of ultrasound (US) with dual-energy CT (DECT) findings in patients presenting with suspected gouty knee arthritis. SUBJECTS AND METHODS: This prospective study included 65 patients (52 men and 13 women; median age, 61.7 years [range, 38-87 years]) with an initial clinical diagnosis of acute gouty knee arthritis who underwent DECT performed using a 128-MDCT scanner and US performed using a 5-18-MHz transducer...
April 27, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29695255/temporomandibular-joint-arthritis-in-juvenile-idiopathic-arthritis-now-what
#12
REVIEW
Matthew L Stoll, Chung H Kau, Peter D Waite, Randy Q Cron
BACKGROUND: Arthritis involving the temporomandibular joint (TMJ) complicates 40 - 96% of cases of juvenile idiopathic arthritis (JIA), potentially leading to devastating changes to form and function. Optimal evaluation and management of this joint remains a matter of ongoing discussion. METHODS: We performed a PubMed search for all articles with keywords "temporomandibular" and "arthritis", covering the dates 2002 through February 28, 2018. A separate PubMed search was performed for all articles with keywords "temporomandibular joint", "arthritis", and "treatment" covering the same dates...
April 25, 2018: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29690705/-comparison-of-bone-destruction-markers-in-patients-with-gouty-arthritis-under-different-musculoskeletal-ultrasonic-manifestations
#13
Y N Fei, S M Tang, G Zhang, Y H Li, M Shao, L F Xie, Y C Zhong, X W Zhang
Objectives: To observe the correlation between the different ultrasonic manifestations of gouty arthritis and the indexes of bone destruction (Dickkopf-1, RANKL), in order to further explore the role of musculoskeletal ultrasonography in the diagnosis and monitoring of gouty arthritis. Methods: 160 cases of gouty arthritis from clinic of the Department of Rheumatology of Peking University People's Hospital between July 2016 and June 2017 were recruited in this study. These patients were examined by musculoskeletal ultrasonography (bilateral first metatarsophalangeal joints, bilateral ankle joints and bilateral knee joints)...
April 3, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29686442/ultrasound-as-a-useful-tool-to-integrate-the-clinical-assessment-of-nail-involvement-in-psoriatic-arthritis
#14
REVIEW
Jessica Gutierrez-Manjarrez, Marwin Gutierrez, Chiara Bertolazzi, Alfonso Afaro-Rodriguez, Carlos Pineda
Developing the skills to adequately assess nail lesions in psoriasis is mandatory for correct interpretation of the pathological features and to provide correct management of psoriatic patients. Although clinical assessment is part of an accurate diagnosis of nail psoriasis, recent advances in the field of imaging are generating growing interest among clinicians exploring its potential role for the assessment of nail psoriasis. We would like to address the attention to ultrasound (US), which is having an impact in different clinical scenarios such as diagnosis, prognosis, and treatment monitoring of nail involvement in psoriatic disease...
2018: Reumatologia
https://www.readbyqxmd.com/read/29685466/gonococcal-tenosynovitis-diagnosed-with-the-aid-of-emergency-department-bedside-ultrasound
#15
Edward Carlin, Colleen Urban, Jessica Sidle, Angela Cirilli, Jennifer Larson, Mark Richman, Daniel Dexeus
BACKGROUND: Gonorrhea is the second most common sexually transmitted infection. Disseminated gonococcal infection (DGI) consists of gonococcal infection plus one or more of the triad of arthritis, tenosynovitis, and dermatitis. Diagnosis in the emergency department (ED) must be suspected clinically, as confirmatory tests are often not available. Point-of-care ultrasound (POCUS) can aid in diagnosis and appropriate management by identifying tenosynovitis and excluding arthritis. CASE REPORT: A 26-year-old man with multiple recent sex partners presented to the ED with slowly progressing right wrist pain and swelling over 5 days...
April 20, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29683837/role-of-interleukin-37-as-a-novel-proangiogenic-factor-in-juvenile-idiopathic-arthritis
#16
Amal Mohamad El-Barbary, Manal Shawky Hussein, Samah Hamdy Almedany, Elsayed Mohamad Rageh, Alaa Mohamed Alsalawy, Marwa Ahmed Aboelhawa, Radwa Mostafa Elkholy, Noha Mohamed Shafik, Ahmed Shukry Elharoun
OBJECTIVE: The aim of this study was to investigate interleukin 37 (IL-37) levels in the serum and synovial fluid of patients with juvenile idiopathic arthritis (JIA), its expression in peripheral blood mononuclear cells, and correlation with disease activity and angiogenesis. METHODS: Seventy JIA patients and 50 control subjects were examined. The Juvenile Arthritis Disease Activity Score in 27 joints (JADAS-27) was calculated. Immunoassays were used to measure the serum and synovial fluid levels of IL-37, vascular endothelial growth factor (VEGF), soluble VEGF receptor 1 (sVEGF-R1), and sVEGF-R2...
April 16, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29679210/gout-of-hand-and-wrist-the-value-of-us-as-compared-with-dect
#17
Andrea S Klauser, Ethan J Halpern, Sylvia Strobl, Mohamed M H Abd Ellah, Johann Gruber, Rosa Bellmann-Weiler, Thomas Auer, Gudrun Feuchtner, Werner Jaschke
OBJECTIVES: The purpose of this study was to compare findings of ultrasound (US) with dual-energy CT (DECT) in patients presenting with suspected gouty hand and wrist arthritis. METHODS: This prospective study included 180 patients (136 men and 44 women, age range, 31- 94 years; mean age, 65.9 years) with an initial clinical diagnosis of acute gouty arthritis who underwent DECT and US examination. Intra- and extra-articular findings of each modality were tabulated and calculated with DECT as gold standard...
April 20, 2018: European Radiology
https://www.readbyqxmd.com/read/29678187/an-unexpected-cause-of-sacroiliitis-in-a-patient-with-gout-and-chronic-psoriasis-with-inflammatory-arthritis-a-case-report
#18
Safi Alqatari, Roberta Visevic, Nina Marshall, John Ryan, Grainne Murphy
BACKGROUND: Inflammatory back pain is a condition characterized by inflammation of the sacroiliac joints and lower spine. It is frequently seen in patients with spondyloarthropathies like ankylosing spondylitis, psoriatic arthritis, enteropathic arthritis and reactive arthritis. Inflammatory back pain can be caused by many other conditions like infection and crystal deposition such as gout. In this case, it is difficult to specifically identify gout as a cause by ordinary imaging like magnetic resonance imaging (MRI) or ultrasound...
April 20, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29672804/imaging-features-of-the-juvenile-inflammatory-arthropathies
#19
Iwona Sudoł-Szopińska, Lennart Jans, Anne Grethe Jurik, Robert Hemke, Iris Eshed, Nathalie Boutry
We discuss the imaging of several juvenile inflammatory arthropathies including juvenile idiopathic arthritis, juvenile systemic lupus erythematosus, juvenile scleroderma, juvenile dermatomyositis, and chronic recurrent multifocal osteomyelitis. Juvenile idiopathic arthritis is the most common autoimmune chronic systemic disease of connective tissue in children. The remaining systemic juvenile connective tissue diseases are rare. However, they require early diagnosis and initiation of treatment to prevent injury, not only to the musculoskeletal system but also to the internal organs, and even death...
April 2018: Seminars in Musculoskeletal Radiology
https://www.readbyqxmd.com/read/29666689/painful-pes-anserine-bursitis-following-total-knee-replacement-surgery-two-cases
#20
Mohamed A M Ariff, Mohd I A C Ros, Nor H M Yahaya
Pes anserine bursitis (PAB) is an inflammation of the bursa located between the medial aspect of the tibia and the hamstring muscles. It is common in patients with degenerative or inflammatory knee arthritis, usually has a self-limiting course and tends to respond well to conservative treatment. However, painful PAB directly following total knee replacement surgery is rare. We report two such cases who were diagnosed via ultrasonography at the Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia, in 2015...
February 2018: Sultan Qaboos University Medical Journal
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