keyword
MENU ▼
Read by QxMD icon Read
search

Fluid kinetics

keyword
https://www.readbyqxmd.com/read/29023522/microencapsulation-of-clostridium-difficile-specific-bacteriophages-using-microfluidic-glass-capillary-devices-for-colon-delivery-using-ph-triggered-release
#1
Gurinder K Vinner, Goran T Vladisavljević, Martha R J Clokie, Danish J Malik
The prevalence of pathogenic bacteria acquiring multidrug antibiotic resistance is a global health threat to mankind. This has motivated a renewed interest in developing alternatives to conventional antibiotics including bacteriophages (viruses) as therapeutic agents. The bacterium Clostridium difficile causes colon infection and is particularly difficult to treat with existing antibiotics; phage therapy may offer a viable alternative. The punitive environment within the gastrointestinal tract can inactivate orally delivered phages...
2017: PloS One
https://www.readbyqxmd.com/read/29023362/glycocalyx-shedding-is-enhanced-by-age-and-correlates-with-increased-fluid-requirement-in-patients-with-major-burns
#2
Akinori Osuka, Hirofumi Kusuki, Kazuhiro Yoneda, Hiroshi Matsuura, Hisatake Matsumoto, Hiroshi Ogura, Masashi Ueyama
BACKGROUND: Massive fluid shift following severe burn injury leads to edema and intravascular fluid loss that may result in burn-induced compartment syndrome (BICS) when corrected by aggressive fluid resuscitation. Factors causing this fluid shift remain unclear. Because glycocalyx regulates endothelial permeability, we hypothesized that glycocalyx shedding would increase fluid requirements in burn patients. This prospective cohort study aimed to identify relationships between shedding of the glycocalyx and fluid requirements following burn injury...
October 11, 2017: Shock
https://www.readbyqxmd.com/read/29017959/8-isoprostane-is-an-early-biomarker-for-oxidative-stress-in-chlorine-induced-acute-lung-injury
#3
Linda Elfsmark, Lina Ågren, Christine Akfur, Anders Bucht, Sofia Jonasson
Inhalation of chlorine (Cl2) may cause oxidative acute lung injury (ALI) characterized by pulmonary edema, pneumonitis, and hyperreactive airways. The aim of the study was to identify possible biomarkers for Cl2-induced ALI. Female BALB/c mice were exposed to Cl2 for 15min using two protocols 1) concentration-dependent response (25-200ppm) and 2) time-kinetics (2h-14days post-exposure). Exposure to 50-200ppm Cl2 caused a concentration-dependent inflammatory response with increased expression of IL-1β, IL-6 and CXCL1/KC in bronchoalveolar lavage fluid 2-6h after exposure which was followed by increased lung permeability and a neutrophilic inflammation 12-24h post-exposure...
October 7, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28992335/how-to-set-the-stage-for-a-full-fledged-clinical-trial-testing-incremental-haemodialysis
#4
Francesco Gaetano Casino, Carlo Basile
Most people who make the transition to maintenance haemodialysis (HD) therapy are treated with a fixed dose of thrice-weekly HD (3HD/week) regimen without consideration of their residual kidney function (RKF). The RKF provides an effective and naturally continuous clearance of both small and middle molecules, plays a major role in metabolic homeostasis, nutritional status and cardiovascular health, and aids in fluid management. The RKF is associated with better patient survival and greater health-related quality of life...
July 21, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28987117/a-kinetic-monte-carlo-approach-to-study-fluid-transport-in-pore-networks
#5
M Apostolopoulou, R Day, R Hull, M Stamatakis, A Striolo
The mechanism of fluid migration in porous networks continues to attract great interest. Darcy's law (phenomenological continuum theory), which is often used to describe macroscopically fluid flow through a porous material, is thought to fail in nano-channels. Transport through heterogeneous and anisotropic systems, characterized by a broad distribution of pores, occurs via a contribution of different transport mechanisms, all of which need to be accounted for. The situation is likely more complicated when immiscible fluid mixtures are present...
October 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28986683/hydroxyapatite-chitosan-biocomposites-synthesized-in-the-simulated-body-fluid-and-their-drug-loading-studies
#6
Tugba Basargan, Nalan Erdol-Aydin, Gulhayat Nasun-Saygili
Hydroxyapatite (HAp) is a bioceramic applied in the biomedical areas, such as matrices for drug release control. Chitosan (CTS), a natural polymer, is another material has been widely investigated for its potential use in the drug delivery systems. In this study, the composites of HAp-CTS are produced in order to investigate their drug loading and release studies. First of all, HAp-CTS composites are produced in the presence of simulated body fluid (SBF). Analysis confirmed the structure of HAp-CTS composites...
October 6, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28985470/analysis-of-polystyrene-toluene-system-through-dynamic-sorption-tests-glass-transitions-and-retrograde-vitrification
#7
Davide Pierleoni, Matteo Minelli, Giuseppe Scherillo, Giuseppe Mensitieri, Valerio Loianno, Francesco Bonavolontà, Ferruccio Doghieri
Exposing a glassy polymer to a fluid phase (in gaseous or liquid state) containing a low molecular weight compound results in the sorption of the latter within the polymer inducing,among other effects, the plasticization of the material which also promotes a change in the glass transition temperature. The amount of sorbed penetrant is often related in a complex fashion to temperature and pressure of the fluid, thus determining that the locus of glass transition, when represented in pressure-temperature coordinates, may display as well rather complex patterns...
October 6, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28983809/temperature-evolution-of-trp-cage-folding-pathways-an-analysis-by-dividing-the-probability-flux-field-into-stream-tubes
#8
Vladimir A Andryushchenko, Sergei F Chekmarev
Owing to its small size and very fast folding rate, the Trp-cage miniprotein has become a benchmark system to study protein folding. Two folding pathways were found to be characteristic of this protein: pathway I, in which the hydrophobic collapse precedes the formation of α-helix, and pathway II, in which the events occur in the reverse order. At the same time, the relative contribution of these pathways at different temperatures as well as the nature of transition from one pathway to the other remain unclear...
October 5, 2017: Journal of Biological Physics
https://www.readbyqxmd.com/read/28973014/microsecond-time-scale-kinetics-of-transient-biochemical-reactions
#9
Sandra Mitić, Marc J F Strampraad, Wilfred R Hagen, Simon de Vries
To afford mechanistic studies in enzyme kinetics and protein folding in the microsecond time domain we have developed a continuous-flow microsecond time-scale mixing instrument with an unprecedented dead-time of 3.8 ± 0.3 μs. The instrument employs a micro-mixer with a mixing time of 2.7 μs integrated with a 30 mm long flow-cell of 109 μm optical path length constructed from two parallel sheets of silver foil; it produces ultraviolet-visible spectra that are linear in absorbance up to 3.5 with a spectral resolution of 0...
2017: PloS One
https://www.readbyqxmd.com/read/28964176/plasma-flow-reactor-for-steady-state-monitoring-of-physical-and-chemical-processes-at-high-temperatures
#10
Batikan Koroglu, Marco Mehl, Michael R Armstrong, Jonathan C Crowhurst, David G Weisz, Joseph M Zaug, Zurong Dai, Harry B Radousky, Alex Chernov, Erick Ramon, Elissaios Stavrou, Kim Knight, Andrea L Fabris, Mark A Cappelli, Timothy P Rose
We present the development of a steady state plasma flow reactor to investigate gas phase physical and chemical processes that occur at high temperature (1000 < T < 5000 K) and atmospheric pressure. The reactor consists of a glass tube that is attached to an inductively coupled argon plasma generator via an adaptor (ring flow injector). We have modeled the system using computational fluid dynamics simulations that are bounded by measured temperatures. In situ line-of-sight optical emission and absorption spectroscopy have been used to determine the structures and concentrations of molecules formed during rapid cooling of reactants after they pass through the plasma...
September 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28956529/absorption-kinetics-of-flurbiprofen-axetil-microspheres-in-cerebrospinal-fluid-a-pilot-study%C3%A2
#11
Hong Zhang, Jian Gu, Yi Feng, Haiyan An
OBJECTIVE: The purpose of this study is to investigate the absorption dynamics of flurbiprofen axetil in cerebrospinal fluid. MATERIALS AND METHODS: We analyzed the concentrations of flurbiprofen in peripheral venous blood and cerebrospinal fluid (CSF) to explore the absorption dynamics of flurbiprofen axetil loaded in lipid microspheres in CSF. 72 adult patients who planned to undergo selective operations under spinal anesthesia or combined spinal-epidural anesthesia were intravenously injected with flurbiprofen axetil (1 mg/kg) and randomly divided into nine groups according to the sampling time after administration: 5 (T5), 10 (T10), 15 (T15), 20 (T20), 25 (T25), 30 (T30), 35 (T35), 40 (T40), and 45 minutes (T45)...
September 28, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28951594/structural-and-transport-properties-of-ammonia-along-the-principal-hugoniot
#12
Dafang Li, Cong Wang, Jun Yan, Zhen-Guo Fu, Ping Zhang
We investigate, via quantum molecular dynamics simulations, the structural and transport properties of ammonia along the principal Hugoniot for temperatures up to 10 eV and densities up to 2.6 g/cm(3). With the analysis of the molecular dynamics trajectories by use of the bond auto-correlation function, we identify three distinct pressure-temperature regions for local chemical structures of ammonia. We derive the diffusivity and viscosity of strong correlated ammonia with high accuracy through fitting the velocity and stress-tensor autocorrelation functions with complex functional form which includes structures and multiple time scales...
September 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28950626/kinetic-approach-to-relativistic-dissipation
#13
A Gabbana, M Mendoza, S Succi, R Tripiccione
Despite a long record of intense effort, the basic mechanisms by which dissipation emerges from the microscopic dynamics of a relativistic fluid still elude complete understanding. In particular, several details must still be finalized in the pathway from kinetic theory to hydrodynamics mainly in the derivation of the values of the transport coefficients. In this paper, we approach the problem by matching data from lattice-kinetic simulations with analytical predictions. Our numerical results provide neat evidence in favor of the Chapman-Enskog [The Mathematical Theory of Non-Uniform Gases, 3rd ed...
August 2017: Physical Review. E
https://www.readbyqxmd.com/read/28950548/particle-based-modeling-of-heterogeneous-chemical-kinetics-including-mass-transfer
#14
A Sengar, J A M Kuipers, Rutger A van Santen, J T Padding
Connecting the macroscopic world of continuous fields to the microscopic world of discrete molecular events is important for understanding several phenomena occurring at physical boundaries of systems. An important example is heterogeneous catalysis, where reactions take place at active surfaces, but the effective reaction rates are determined by transport limitations in the bulk fluid and reaction limitations on the catalyst surface. In this work we study the macro-micro connection in a model heterogeneous catalytic reactor by means of stochastic rotation dynamics...
August 2017: Physical Review. E
https://www.readbyqxmd.com/read/28946219/absorption-and-metabolism-of-yerba-mate-phenolic-compounds-in-humans
#15
Miren Gómez-Juaristi, Sara Martínez-López, Beatriz Sarria, Laura Bravo, Raquel Mateos
Bioavailability of yerba mate phenolic compounds was assessed in healthy humans. More than 34 metabolites were identified in biological fluids, mainly sulfated conjugates of caffeic and ferulic/isoferulic acids, in addition to non-metabolized caffeoyl-, feruloyl- and p-coumaroilquinic acids, with rapid appearance and clearance in plasma indicative of small intestinal absorption. These compounds amounted to 13.1% of the urinary metabolites. Delayed absorption of dihydrocaffeic, dihydroferulic and dihydrocoumaric acids and their phase II metabolites, in addition to feruloylglycine, pointed to their microbial origin and colonic absorption, accounting for 81...
February 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28943226/influences-of-red-blood-cell-and-platelet-counts-on-the-distribution-and-elimination-of-crystalloid-fluid
#16
Robert G Hahn
BACKGROUND AND OBJECTIVE: A high number of blood cells increases the viscosity of the blood. The present study explored whether variations in blood cell counts are relevant to the distribution and elimination of infused crystalloid fluid. MATERIALS AND METHODS: On three different occasions, 10 healthy male volunteers received an intravenous infusion of 25mL/kg of Ringer's acetate, Ringer's lactate, and isotonic saline over 30min. Blood hemoglobin and urinary excretion were monitored for 4h and used as input in a two-volume kinetic model, using nonlinear mixed effects software...
August 3, 2017: Medicina
https://www.readbyqxmd.com/read/28935694/cellular-kinetics-of-ctl019-in-relapsed-refractory-b-cell-acute-lymphoblastic-leukemia-and-chronic-lymphocytic-leukemia
#17
Karen Thudium Mueller, Shannon L Maude, David L Porter, Noelle Frey, Patricia Wood, Xia Han, Edward Waldron, Abhijit Chakraborty, Rakesh Awasthi, Bruce L Levine, J Joseph Melenhorst, Stephan A Grupp, Carl H June, Simon F Lacey
Tisagenlecleucel (CTL019) is an investigational immunotherapy that involves reprogramming a patient's own T cells with a transgene encoding a chimeric antigen receptor to identify and eliminate CD19-expressing cells. We previously reported that CTL019 achieved impressive clinical efficacy in patients with relapsed/refractory B-cell acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia (CLL), including the expansion and persistence of CTL019 cells, which correlates with response to therapy. Here, we performed formal cellular kinetic analyses of CTL019 in a larger cohort of 103 patients treated with CTL019 in 2 different diseases (ALL and CLL)...
September 21, 2017: Blood
https://www.readbyqxmd.com/read/28926768/the-effect-of-irrigation-time-and-type-of-irrigation-fluid-on-cartilage-surface-friction
#18
F Stärke, F Awiszus, C H Lohmann, C Stärke
It is known that fluid irrigation used during arthroscopic procedures causes a wash-out of lubricating substances from the articular cartilage surface and leads to increased friction. It was the goal of this study to investigate whether this effect depends on the time of irrigation and type of fluid used. Rabbit hind legs were used for the tests. The knees were dissected and the friction coefficient of the femoral cartilage measured against glass in a boundary lubrication state. To determine the influence of irrigation time and fluid, groups of 12 knees received either no irrigation (control), 15, 60 or 120min of irrigation with lactated Ringer's solution or 60min of irrigation with normal saline or a sorbitol/mannitol solution...
September 9, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28919372/biological-applications-of-kinetics-of-wetting-and-spreading
#19
REVIEW
G Ahmed, O Arjmandi Tash, J Cook, A Trybala, V Starov
Wetting and spreading kinetics of biological fluids has gained a substantial interest recently. The importance of these fluids in our lives has driven the pace of publications. Globally scientists have ever growing interest in understanding wetting phenomena due to its vast applications in biological fluids. It is impractical to review extremely large number of publications in the field of kinetics of complex biological fluids and cosmetic solutions on diverse surfaces. Therefore, biological and cosmetic applications of wetting and spreading dynamics are considered in the following areas: (i) Spreading of Newtonian liquids in the case of non-porous and porous substrates...
August 18, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28915852/a-novel-frameshift-grn-mutation-results-in-frontotemporal-lobar-degeneration-with-a-distinct-clinical-phenotype-in-two-siblings-case-report-and-literature-review
#20
Takashi Hosaka, Kazuhiro Ishii, Takeshi Miura, Naomi Mezaki, Kensaku Kasuga, Takeshi Ikeuchi, Akira Tamaoka
BACKGROUND: Progranulin gene (GRN) mutations are major causes of frontotemporal lobar degeneration. To date, 68 pathogenic GRN mutations have been identified. However, very few of these mutations have been reported in Asians. Moreover, some GRN mutations manifest with familial phenotypic heterogeneity. Here, we present a novel GRN mutation resulting in frontotemporal lobar degeneration with a distinct clinical phenotype, and we review reports of GRN mutations associated with familial phenotypic heterogeneity...
September 15, 2017: BMC Neurology
keyword
keyword
31590
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"