keyword
MENU ▼
Read by QxMD icon Read
search

Fluid kinetics

keyword
https://www.readbyqxmd.com/read/28723149/cyclewise-operation-of-printed-mos2-transistor-biosensors-for-rapid-biomolecule-quantification-at-femtomolar-levels
#1
Byunghoon Ryu, Hongsuk Nam, Bo-Ram Oh, Yujing Song, Pengyu Chen, Younggeun Park, Wenjie Wan, Katsuo Kurabayashi, Xiaogan Liang
Field-effect transistors made from MoS2 and other emerging layered semiconductors have been demonstrated to be able to serve as ultrasensitive biosensors. However, such nanoelectronic sensors still suffer seriously from a series of challenges associated with the poor compatibility between electronic structures and liquid analytes. These challenges hinder the practical biosensing applications that demand rapid, low-noise, highly specific biomolecule quantification at femtomolar levels. To address such challenges, we study a cyclewise process for operating MoS2 transistor biosensors, in which a series of reagent fluids are delivered to the sensor in a time-sequenced manner and periodically set the sensor into four assay-cycle stages, including incubation, flushing, drying, and electrical measurement...
February 24, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28722444/topographically-flat-nanoplasmonic-sensor-chips-for-biosensing-and-materials-science
#2
Ferry Anggoro Ardy Nugroho, Rickard Frost, Tomasz J Antosiewicz, Joachim Fritzsche, Elin M Larsson Langhammer, Christoph Langhammer
Nanoplasmonic sensors typically comprise arrangements of noble metal nanoparticles on a dielectric support. Thus, they are intrinsically characterized by surface topography with corrugations at the 10-100 nm length scale. While irrelevant in some bio- and chemosensing applications, it is also to be expected that the surface topography significantly influences the interaction between solids, fluids, nanoparticles and (bio)molecules, and the nanoplasmonic sensor surface. To address this issue, we present a wafer-scale nanolithography-based fabrication approach for high-temperature compatible, chemically inert, topographically flat, and laterally homogeneous nanoplasmonic sensor chips...
January 27, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28720856/optimization-of-microfluidic-biosensor-efficiency-by-means-of-fluid-flow-engineering
#3
Marwa Selmi, Mohamed Hichem Gazzah, Hafedh Belmabrouk
Binding reaction kinetics of analyte-ligand at the level of a sensitive membrane into a microchannel of a biosensor has been limited by the formation of the boundary diffusion layer. Therefore, the response time increases and affects the overall performance of a biosensor. In the present work, we develop an approach to engineer fluid streams into a complex configuration in order to improve the binding efficiency. We investigate numerically the flow deformations around a parallelepiped with square cross-section inside the microfluidic channel and exploit these deformations to simulate the analyte transport to the sensitive membrane and enhance both association and dissociation processes...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28717995/ovomucin-nanoparticles-promising-carriers-for-mucosal-delivery-of-drugs-and-bioactive-compounds
#4
Ali Akbari, Jianping Wu
Ovomucin, with a similar structure to mucin and gelation ability at room temperature, is a potential mucosal carrier. To evaluate this potential, the mucoadhesive property of ovomucin was studied by the tensile strength and rheology methods, and compared with three known mucoadhesive polymers, chitosan, polyacrylic acid (PAA), and alginate. Ovomucin particles were basically spherical in shape with an average size of ~572, 235 and 54 nm prepared at pH 5, 6.5, and 9, respectively. The absolute value of the zeta potential increased from ~ -51 mV at pH 5 to ~ -59 and -91 mV at pH 6...
July 17, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28714248/functionalized-superparamagnetic-nanoparticles-with-a-polymer-containing-%C3%AE-cyclodextrin-for-the-extraction-of-sertraline-hydrochloride-in-biological-samples
#5
Rahele Shamekhi, Homayon Ahmad Panahi, Haniyeh Sadat Alaei, Elham Moniri
In this study, a novel magnetic nanoadsorbent was synthesized by grafting β-cyclodextrin onto the modified surface of Fe3 O4 nanoparticles for the sorption and extraction of sertraline hydrochloride from human biological fluids. The extracted sertraline hydrochloride was measured by high-performance liquid chromatography. The grafted nanosorbent was confirmed by Fourier transform infrared spectroscopy, transmission electron microscopy, thermogravimetric analysis and elemental analysis. The kinetic sorption of sertraline hydrochloride by magnetic nanosorbent was 1 h...
July 17, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28713213/secondary-motion-in-three-dimensional-branching-networks
#6
Abhijit Guha, Kaustav Pradhan
A major aim of the present work is to understand and thoroughly document the generation, the three-dimensional distribution, and the evolution of the secondary motion as the fluid progresses downstream through a branched network. Six generations (G0-G5) of branches (involving 63 straight portions and 31 bifurcation modules) are computed in one go; such computational challenges are rarely taken in the literature. More than 30 × 10(6) computational elements are employed for high precision of computed results and fine quality of the flow visualization diagrams...
June 2017: Physics of Fluids
https://www.readbyqxmd.com/read/28692273/protein-mixture-segregation-at-coffee-ring-real-time-imaging-of-protein-ring-precipitation-by-ftir-spectromicroscopy
#7
Sun Choi, Giovanni Birarda
During natural drying process, all solutions and suspensions tend to form the so-called "coffee-ring" deposits. This phenomenon, by far, has been interpreted by the hydrodynamics of evaporating fluids. However, in this study, by applying Fourier transform infrared imaging (FTIRI), it is possible to observe the segregation and separation of a protein mixture at the "ring", hence we suggest a new way to interpret "coffee-ring effect" of solutions. The results explore the dynamic process that leads to the ring formation in case of model plasma proteins, such as BGG (bovine γ globulin), BSA (bovine serum albumin), and Hfib (human fibrinogen), and also report fascinating discovery of the segregation at the ring deposits of two model proteins BGG and BSA, which can be explained by an energy kinetic model, only...
July 18, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28688449/efficient-chemical-potential-evaluation-with-kinetic-monte-carlo-method-and-non-uniform-external-potential-lennard-jones-fluid-liquid-and-solid
#8
E A Ustinov
The aim of this paper is to present a method of a direct evaluation of the chemical potential of fluid, liquid, and solid with kinetic Monte Carlo simulation. The method is illustrated with the 12-6 Lennard-Jones (LJ) system over a wide range of density and temperature. A distinctive feature of the methodology used in the present study is imposing an external potential on the elongated simulation box to split the system into two equilibrium phases, one of which is substantially diluted. This technique provides a reliable direct evaluation of the chemical potential of the whole non-uniform system (including that of the uniformly distributed dense phase in the central zone of the box), which, for example, is impossible in simulation of the uniform crystalline phase...
July 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28668612/controlled-release-of-doxycycline-from-gum-acacia-poly-sodium-acrylate-microparticles-for-oral-drug-delivery
#9
S K Bajpai, Mamta Jadaun, M Bajpai, Pooja Jyotishi, Farhan Ferooz Shah, Seema Tiwari
In the present work, Doxycycline loaded gum acacia (GA)/poly(sodium acrylate) (SA) hydrogels were prepared for the oral drug delivery of model drug Doxycycline. The hydrogels were characterized by X-ray diffraction analysis (XRD), Fourier transform infrared spectroscopy (FTIR) scanning electron microscopy (SEM) and Zeta potential. The dynamic release of Doxycycline was investigated in the physiological fluids at 37°C. Various kinetic models such as Power function model, Schott model and Higuchi model were applied to interpret the release data...
June 29, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28664159/rediscovering-beta-2-microglobulin-as-a-biomarker-across-the-spectrum-of-kidney-diseases
#10
REVIEW
Christos P Argyropoulos, Shan Shan Chen, Yue-Harn Ng, Maria-Eleni Roumelioti, Kamran Shaffi, Pooja P Singh, Antonios H Tzamaloukas
There is currently an unmet need for better biomarkers across the spectrum of renal diseases. In this paper, we revisit the role of beta-2 microglobulin (β2M) as a biomarker in patients with chronic kidney disease and end-stage renal disease. Prior to reviewing the numerous clinical studies in the area, we describe the basic biology of β2M, focusing in particular on its role in maintaining the serum albumin levels and reclaiming the albumin in tubular fluid through the actions of the neonatal Fc receptor...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28655888/moving-and-unsinkable-graphene-sheets-immobilized-enzyme-for-microfluidic-biocatalysis
#11
An Gong, Chang-Tong Zhu, Yan Xu, Fang-Qin Wang, D'assise Kinfack Tsabing, Fu-An Wu, Jun Wang
Enzymatic catalysis in microreactors has attracted growing scientific interest because of high specific surface enabling heat and mass transfer and easier control of reaction parameters in microreactors. However, two major challenges that limit their application are fast inactivation and the inability to the biocatalysts in microchannel reactors. A fluid and unsinkable immobilized enzyme were firstly applied in a microchannel reactor for biocatalysis in this study. Functionalized forms of graphene-immobilized naringinase flowing in microchannels have yielded excellent results for isoquercitrin production...
June 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28653244/%C3%AE-hydroxybutyric-acid-ghb-pharmacokinetics-and-pharmacodynamics-semi-mechanistic-and-physiologically-relevant-pk-pd-model
#12
Rutwij A Dave, Kristin E Follman, Marilyn E Morris
An overdose of γ-hydroxybutyric acid (GHB), a drug of abuse, results in fatality caused by severe respiratory depression. In this study, a semi-mechanistic pharmacokinetic/pharmacodynamic (PK/PD) model was developed to characterize monocarboxylate transporter 1 (MCT1)-mediated transport of GHB, as well as effects of GHB on respiration frequency, for IV doses of 200, 600, and 1500 mg/kg in rats. The proposed PK/PD model for GHB consists of nonlinear metabolism of GHB in the liver, MCT1-mediated renal reabsorption with physiologically relevant concurrent fluid reabsorption, MCT1-mediated uptake into the brain, and direct effects of binding of GHB to GABAB receptors on the PD parameter, respiration frequency...
June 26, 2017: AAPS Journal
https://www.readbyqxmd.com/read/28652925/effect-of-feeding-garlic-leaves-on-rumen-fermentation-methane-emission-plasma-glucose-kinetics-and-nitrogen-utilization-in-sheep
#13
Arvinda Panthee, Ayana Matsuno, Mohammad Al-Mamun, Hiroaki Sano
BACKGROUND: Garlic and its constituents are reported to have been effective in reducing methane emission and also influence glucose metabolism in body; however, studies in ruminants using garlic leaves are scarce. Garlic leaves contain similar compounds as garlic bulbs, but are discarded in field after garlic bulb harvest. We speculate that feeding garlic leaves might show similar effect as garlic constituents in sheep and could be potential animal feed supplement. Thus, we examined the effect of freeze dried garlic leaves (FDGL) on rumen fermentation, methane emission, plasma glucose kinetics and nitrogen utilization in sheep...
2017: Journal of Animal Science and Technology
https://www.readbyqxmd.com/read/28652002/preliminary-kinetic-evaluation-of-an-immobilized-polysaccharide-sub-2%C3%AE-m-column-using-a-low-dispersion-supercritical-fluid-chromatograph
#14
Terry A Berger
The performance of a 3×50mm, 1.6μm dp column with an immobilized polysaccharide stationary phase (ChiralPak IA-U) was evaluated for efficiency, and pressure drop, with respect to flow rate and modifier concentration using supercritical fluid chromatography (SFC). This appears to be the first such report using such a column in SFC. A unique low dispersion (ultra-high performance) SFC was used for the evaluation. The minimum reduced plate height of 2.78, indicates that the maximum efficiency was similar to or better than coated polysaccharide columns...
August 11, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28647260/numerical-simulation-of-flow-hydrodynamics-of-struvite-pellets-in-a-liquid-solid-fluidized-bed
#15
Xin Ye, Dongyuan Chu, Yaoyin Lou, Zhi-Long Ye, Ming Kuang Wang, Shaohua Chen
Phosphorus recovery in the form of struvite has been aroused in recent decades for its dual advantages in eutrophication control and resource protection. The usage of the struvite products is normally determined by the size which is largely depended on the hydrodynamics. In this study, flow behavior of struvite pellets was simulated by means of Eulerian-Eulerian two-fluid model combining with kinetic theory of granular flow in a liquid-solid fluidized bed reactor (FBR). A parametric study including the mesh size, time step, discretization strategy, turbulent model and drag model was first developed, followed by the evaluations of crucial operational conditions, particle characteristics and reactor shapes...
July 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28647145/total-peak-shape-analysis-detection-and-quantitation-of-concurrent-fronting-tailing-and-their-effect-on-asymmetry-measurements
#16
M Farooq Wahab, Darshan C Patel, Daniel W Armstrong
Most peak shapes obtained in separation science depart from linearity for various reasons such as thermodynamic, kinetic, or flow based effects. An indication of the nature of asymmetry often helps in problem solving e.g. in column overloading, slurry packing, buffer mismatch, and extra-column band broadening. However, existing tests for symmetry/asymmetry only indicate the skewness in excess (tail or front) and not the presence of both. Two simple graphical approaches are presented to analyze peak shapes typically observed in gas, liquid, and supercritical fluid chromatography as well as capillary electrophoresis...
August 4, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28642044/crossregulation-between-the-insertion-of-hexadecylphosphocholine-miltefosine-into-lipid-membranes-and-their-rheology-and-lateral-structure
#17
Yenisleidy de Las Mercedes Zulueta Díaz, María Laura Fanani
Hexadecylphosphocholine (HePC, miltefosine) is an alkylphospholipid used clinically for the topical treatment of cancer and against leishmaniasis. The mechanism of action of HePC, not yet elucidated, involves its insertion into the plasma membrane, affecting lipid homeostasis. It has also been proposed that HePC directly affects lipid raft stability and function in cell membranes. The present work deals with two main questions in the understanding of the action of HePC: the bases for membrane selectivity and as a membrane perturbator agent...
June 20, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28632435/relative-effects-of-plasma-fibrinogen-concentrate-and-factor-xiii-on-rotem-coagulation-profiles-in-an-in-vitro-model-of-massive-transfusion-in-trauma
#18
David E Schmidt, Märit Halmin, Agneta Wikman, Anders Östlund, Anna Ågren
Massive traumatic haemorrhage is aggravated through the development of trauma-induced coagulopathy, which is managed by plasma transfusion and/or fibrinogen concentrate administration. It is yet unclear whether these treatments are equally potent in ensuring adequate haemostasis, and whether additional factor XIII (FXIII) administration provides further benefits. In this study, we compared ROTEM whole blood coagulation profiles after experimental massive transfusion with different transfusion regimens in an in vitro model of dilution- and transfusion-related coagulopathy...
June 20, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28629540/kinetics-and-dose-dependency-of-intranasal-oxytocin-effects-on-amygdala-reactivity
#19
Franny B Spengler, Johannes Schultz, Dirk Scheele, Maximiliane Essel, Wolfgang Maier, Markus Heinrichs, René Hurlemann
BACKGROUND: Current neuroimaging perspectives on a variety of mental disorders emphasize dysfunction of the amygdala. The neuropeptide oxytocin (OXT), a key mediator in the regulation of social cognition and behavior, accumulates in cerebrospinal fluid after intranasal administration in macaques and humans and modulates amygdala reactivity in both species. However, the translation of neuromodulatory OXT effects to novel treatment approaches is hampered by the absence of studies defining the most effective dose and dose-response latency for targeting the amygdala...
May 10, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28628981/biodiesel-synthesis-from-calophyllum-inophyllum-oil-with-different-supercritical-fluids
#20
Neha Lamba, Kaveri Gupta, Jayant M Modak, Giridhar Madras
Biodiesel or fatty acid methyl esters (FAMEs) is primarily synthesized using edible vegetable oils and methanol with a catalyst. However, in the present study, FAMEs were synthesized from a non-edible oil (Calophyllum inophyllum also called as sura honne, Punnagam, Alexandrian Laurel) in different supercritical fluids: methanol (MeOH), methyl tert-butyl ether (MTBE), methyl acetate (MeOAc) and dimethyl carbonate (DMC) non-catalytically. Reactions were performed from 523K to 673K at 30MPa with a molar ratio of 40:1 with times varying from 3min to 3h...
October 2017: Bioresource Technology
keyword
keyword
31590
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"