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Diabetes Type 1

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https://www.readbyqxmd.com/read/28829977/hdl-subclasses-and-the-common-cetp-taqib-variant-predict-the-incidence-of-microangiopatic-complications-in-type-2-diabetic-women-a-9years-follow-up-study
#1
Giuseppina T Russo, Annalisa Giandalia, Elisabetta L Romeo, Marco Muscianisi, Maria Concetta Ruffo, Angela Alibrandi, Alessandra Bitto, Fiorella Forte, Andrea Grillone, Bela Asztalos, Domenico Cucinotta
AIMS: Diabetic kidney disease (DKD) and retinopathy (DR) develop in a considerable number of subjects with Type 2 Diabetes (T2D) despite the achievement of the recommended targets for glycaemia and blood pressure. Atherogenic dyslipidemia may play a relevant role, especially in T2DM women. METHODS: We report our findings on the effect of diabetic dyslipidaemia, the HDL subclasses distribution and the common cholesteryl ester transfer protein (CETP)TaqIB variant on the incidence or the progression of DKD and DR in 97 T2D women, after a ∼9years of follow-up...
July 28, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28829491/the-effect-of-sitagliptin-on-obese-patients-with-insulin-treatment-induced-diabetes-mellitus
#2
S Li, H Li, R Wang, J-P Zhang
OBJECTIVE: The objective of the present study was to observe the effect of sitagliptin on obese patients with insulin treatment-induced diabetes mellitus. PATIENTS AND METHODS: A total of 120 obese patients with insulin treatment-induced diabetes mellitus were consecutively selected and divided into the control group (n=35), observation group 1 (n=40), and observation group 2 (n=45). The control group received different types or doses of insulin, observation group 1 received insulin combined with metformin, and observation group 2 received insulin combined with sitagliptin...
August 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28829396/the-genetic-architecture-of-type-1-diabetes
#3
REVIEW
Samuel T Jerram, Richard David Leslie
Type 1 diabetes (T1D) is classically characterised by the clinical need for insulin, the presence of disease-associated serum autoantibodies, and an onset in childhood. The disease, as with other autoimmune diseases, is due to the interaction of genetic and non-genetic effects, which induce a destructive process damaging insulin-secreting cells. In this review, we focus on the nature of this interaction, and how our understanding of that gene-environment interaction has changed our understanding of the nature of the disease...
August 22, 2017: Genes
https://www.readbyqxmd.com/read/28829163/effect-of-dapagliflozin-on-glycemic-control-weight-and-blood-pressure-in-patients-with-type-2-diabetes-attending-a-specialist-endocrinology-practice-in-canada-a-retrospective-cohort-analysis
#4
Ruth E Brown, Nikhil Gupta, Ronnie Aronson
BACKGROUND: In randomized clinical trials, dapagliflozin has been shown to improve glycemic control, weight, and blood pressure. However, there is little real-world evidence of the effectiveness of dapagliflozin. The objective of this study is to investigate the real-world treatment outcomes of patients with type 2 diabetes (T2D) who initiated dapagliflozin in a referral-based endocrinology practice. METHODS: This study was a retrospective cohort analysis of patients with T2D who initiated dapagliflozin in 2015, using data from a large, specialist diabetes registry in Canada...
August 22, 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28829160/venous-arterialized-venous-or-capillary-glucose-reference-measurements-for-the-accuracy-assessment-of-a-continuous-glucose-monitoring-system
#5
Jort Kropff, Sigrid C van Steen, Peter deGraaff, Man W Chan, Rombout B E van Amstel, J Hans DeVries
BACKGROUND: Different reference methods are used for the accuracy assessment of continuous glucose monitoring (CGM) systems. The effect of using venous, arterialized-venous, or capillary reference measurements on CGM accuracy is unclear. METHODS: We evaluated 21 individuals with type 1 diabetes using a capillary calibrated CGM system. Venous or arterialized-venous reference glucose samples were taken every 15 min at two separate visits and assessed per YSI 2300 STAT Plus...
August 22, 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28828933/impact-of-timely-treatment-intensification-on-glycemic-goal-achievement-in-patients-with-type-2-diabetes-failing-metformin-monotherapy
#6
Rohan Mahabaleshwarkar, Megan Templin, Frank Gohs, Holly Mulder, Andrea DeSantis, Flavia Ejzykowicz, Swapnil Rajpathak, Nick Wilkins
Purpose The purpose of the study was to examine the association between timely treatment intensification (TTI) and glycemic goal achievement in patients with type 2 diabetes (T2D) failing metformin monotherapy (MM). Methods This study was set at a large integrated health care system in the United States. The study cohort included T2D patients aged 18 to 85 years who were on MM between January 2009 and September 2013 and had an uncontrolled glycated hemoglobin (A1C) reading (≥8%) after at least 3 months of MM (corresponding date was index date)...
August 1, 2017: Diabetes Educator
https://www.readbyqxmd.com/read/28828521/recombinant-lactococcus-lactis-expressing-bioactive-exendin-4-to-promote-insulin-secretion-and-beta-cell-proliferation-in-vitro
#7
Zhu Zeng, Rui Yu, Fanglei Zuo, Bo Zhang, Huiqin Ma, Shangwu Chen
In recent years, therapeutic peptides have garnered great interest in the pharmaceutical industry for the treatment of diabetes. Lactic acid bacteria (LAB) are an appealing vehicle for safe and convenient oral delivery of bioactive peptide and protein drugs. Exendin-4 (Exd4) is a glucagon-like protein-1 (GLP-1) receptor agonist that is considered an excellent therapeutic peptide drug for type 2 diabetes due to its longer-lasting bioactivity, resulting from resistance to dipeptidyl peptidase 4. We explored Lactococcus lactis with the nisin-controlled gene expression (NICE) system as an oral delivery system for recombinant (r) Exd4 peptide in situ...
August 21, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28828487/continuous-glucose-monitoring-versus-usual-care-in-patients-with-type-2-diabetes-receiving-multiple-daily-insulin-injections-a-randomized-trial
#8
Roy W Beck, Tonya D Riddlesworth, Katrina Ruedy, Andrew Ahmann, Stacie Haller, Davida Kruger, Janet B McGill, William Polonsky, David Price, Stephen Aronoff, Ronnie Aronson, Elena Toschi, Craig Kollman, Richard Bergenstal
Background: Continuous glucose monitoring (CGM), which studies have shown is beneficial for adults with type 1 diabetes, has not been well-evaluated in those with type 2 diabetes receiving insulin. Objective: To determine the effectiveness of CGM in adults with type 2 diabetes receiving multiple daily injections of insulin. Design: Randomized clinical trial. (The protocol also included a type 1 diabetes cohort in a parallel trial and subsequent second trial...
August 22, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28828484/presence-of-peripheral-neuropathy-is-associated-with-progressive-thinning-of-retinal-nerve-fiber-layer-in-type-1-diabetes
#9
Cirous Dehghani, Sangeetha Srinivasan, Katie Edwards, Nicola Pritchard, Anthony W Russell, Rayaz A Malik, Nathan Efron
Purpose: Reduced retinal nerve fiber layer (RNFL) thickness has been demonstrated in patients with diabetic peripheral neuropathy (DPN) in cross-sectional studies. This prospective study defines longitudinal alterations to the RNFL thickness in individuals with type 1 diabetes without (DPN-ve) and with (DPN+ve) DPN and in relation to risk factors for nerve damage. Methods: A cohort of 105 individuals with type 1 diabetes (20% DPN+ve) with predominantly mild or no retinopathy and no previous retinal photocoagulation underwent spectral-domain optical coherence tomography (SD-OCT) at baseline, 2 years, and 4 years...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28828479/development-and-validation-of-a-tool-to-identify-patients-with-type-2-diabetes-at-high-risk-of-hypoglycemia-related-emergency-department-or-hospital-use
#10
Andrew J Karter, E Margaret Warton, Kasia J Lipska, James D Ralston, Howard H Moffet, Geoffrey G Jackson, Elbert S Huang, Donald R Miller
Importance: Hypoglycemia-related emergency department (ED) or hospital use among patients with type 2 diabetes (T2D) is clinically significant and possibly preventable. Objective: To develop and validate a tool to categorize risk of hypoglycemic-related utilization in patients with T2D. Design, Setting, and Participants: Using recursive partitioning with a split-sample design, we created a classification tree based on potential predictors of hypoglycemia-related ED or hospital use...
August 21, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28828353/impact-of-poor-glycemic-control-of-type-2-diabetes-mellitus-on-serum-prostate-specific-antigen-concentrations-in-men
#11
Hasan Anıl Atalay, Murat Akarsu, Lutfi Canat, Volkan Ülker, İlter Alkan, Unsal Ozkuvancı
BACKGROUND: To evaluate the impact of poor glycemic control of type 2 diabetes mellitus (T2DM) on serum prostate-specific antigen (PSA) concentrations in men. METHODS: We performed a prospective analysis of 215 consecutive patients affected by erectile dysfunction (ED). ED was evaluated using the IIEF-5 questionnaire and the poor glycemic control (PGC) of T2DM was assessed according to the HbA1c criteria (International Diabetes Federation). Patients were divided into PGC group (HbA1c ≥ 7%) and control group (CG) (HbA1c < 6%)...
September 2017: Prostate International
https://www.readbyqxmd.com/read/28828242/genome-wide-association-study-identifies-novel-type-ii-diabetes-risk-loci-in-jordan-subpopulations
#12
Rana Dajani, Jin Li, Zhi Wei, Michael E March, Qianghua Xia, Yousef Khader, Nancy Hakooz, Raja Fatahallah, Mohammed El-Khateeb, Ala Arafat, Tareq Saleh, Abdel Rahman Dajani, Zaid Al-Abbadi, Mohamed Abdul Qader, Abdel Halim Shiyab, Anwar Bateiha, Kamel Ajlouni, Hakon Hakonarson
The prevalence of Type II Diabetes (T2D) has been increasing and has become a disease of significant public health burden in Jordan. None of the previous genome-wide association studies (GWAS) have specifically investigated the Middle East populations. The Circassian and Chechen communities in Jordan represent unique populations that are genetically distinct from the Arab population and other populations in the Caucasus. Prevalence of T2D is very high in both the Circassian and Chechen communities in Jordan despite low obesity prevalence...
2017: PeerJ
https://www.readbyqxmd.com/read/28828047/type-1-diabetes-and-thyroid-autoimmunity-in-children
#13
Anca Orzan, Carmen Novac, Mihaiela Mihu, Constantin Ionescu Tirgoviste, Mihaela Balgradean
INTRODUCTION: Autoimmune thyroid disease and type 1 diabetes (T1DM) are two autoimmune diseases frequently associated, especially in pediatric population. Aims: we wanted to determine and ilustrate the relationship between type 1 diabetes and autoimmune thyroiditis and also the factors than can influence it, like gender, age, diabetes duration. Glycemic control was also evaluated for all the patients. MATERIAL AND METHODS: There were studied 256 patients, children and adolescents with T1DM (male/ female: 145/115; 55%/45%)...
December 2016: Mædica
https://www.readbyqxmd.com/read/28827839/lean-diabetes-in-middle-aged-adults-a-joint-analysis-of-the-german-dive-and-dpv-registries
#14
Bettina Hartmann, Stefanie Lanzinger, Peter Bramlage, Felix Groß, Thomas Danne, Siegfried Wagner, Dietmar Krakow, Artur Zimmermann, Christian Malcharzik, Reinhard W Holl
AIMS: To assess differences in demographics, treatment and outcome of lean (LD) compared to overweight and obese people with diabetes clinically classified as type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS: We combined data from the German DIVE (Diabetes Versorgungs-Evaluation) and DPV (Diabetes-Patienten-Verlaufsdokumentation) databases to produce a large cohort of people with T2DM. The characteristics of people with Body Mass Index (BMI) <25 kg/m2, ≥25-30 kg/m2 and ≥30 kg/m2 aged 30 to 50 years were compared, including demographics, cardiovascular (CV) risk factors, comorbidities and outcomes...
2017: PloS One
https://www.readbyqxmd.com/read/28827737/histological-evaluation-of-diabetic-neurodegeneration-in-the-retina-of-zucker-diabetic-fatty-zdf-rats
#15
Klaudia Szabó, Anna Énzsöly, Bulcsú Dékány, Arnold Szabó, Rozina I Hajdú, Tamás Radovits, Csaba Mátyás, Attila Oláh, Lenke K Laurik, Gábor M Somfai, Béla Merkely, Ágoston Szél, Ákos Lukáts
In diabetes, retinal dysfunctions exist prior to clinically detectable vasculopathy, however the pathology behind these functional deficits is still not fully established. Previously, our group published a detailed study on the retinal histopathology of type 1 diabetic (T1D) rat model, where specific alterations were detected. Although the majority of human diabetic patients have type 2 diabetes (T2D), similar studies on T2D models are practically absent. To fill this gap, we examined Zucker Diabetic Fatty (ZDF) rats - a model for T2D - by immunohistochemistry at the age of 32 weeks...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28827705/application-of-sebomics-for-the-analysis-of-residual-skin-surface-components-to-detect-potential-biomarkers-of-type-1-diabetes-mellitus
#16
Satyajit S Shetage, Matthew J Traynor, Marc B Brown, Thomas M Galliford, Robert P Chilcott
Metabolic imbalance in chronic diseases such as type-1 diabetes may lead to detectable perturbations in the molecular composition of residual skin surface components (RSSC). This study compared the accumulation rate and the composition of RSSC in type-1 diabetic patients with those in matched controls in order to identify potential biomarkers of the disease. Samples of RSSC were collected from the foreheads of type-1 diabetic (n = 55) and non-diabetic (n = 58) volunteers. Samples were subsequently analysed to identify individual components (sebomic analysis)...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28827604/sarcopenia-is-independently-associated-with-diabetic-foot-disease
#17
Qingfeng Cheng, Jinbo Hu, Ping Yang, Xueting Cao, Xuefeng Deng, Qin Yang, Zhiping Liu, Shumin Yang, Richa Goswami, Yue Wang, Ting Luo, Kun Liao, Qifu Li
The aim of this study was to investigate the association of sarcopenia and diabetic foot disease (DFD) in a cross-sectional study. Body composition was assessed using dual-energy X-ray-absorptiometry (DXA) among 1105 patients with type 2 diabetes (120 patients with newly diagnosed DFD [DFD duration less than 3 months]). Severity of DFD was assessed, referring to foot ulcers, Wagner grade and the percentage of amputation. Skeletal muscle index (SMI) was calculated, and sarcopenia was defined as SMI less than 7...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28827484/type-1-diabetes-celiac-disease-and-neuropathy-a-nationwide-cohort-study
#18
Sujata Thawani, Thomas H Brannagan, Benjamin Lebwohl, Kaziwe Mollazadegan, Peter H R Green, Jonas F Ludvigsson
OBJECTIVE: Both type 1 diabetes (T1D) and celiac disease (CD) have been linked to an increased risk of neuropathy. This study examined the risk of neuropathy in patients with T1D compared with patients with both T1D and CD. METHODS: In a nationwide population-based cohort, T1D was defined as having a diagnosis of diabetes between 1964 and 2009 recorded in the Swedish National Patient Register in individuals ≤30 years of age. CD was defined as having villous atrophy (Marsh histopathology stage III) on small intestinal biopsy...
September 2017: Journal of Clinical Neuromuscular Disease
https://www.readbyqxmd.com/read/28827476/angiotensin-ii-type-2-receptor-and-receptor-mas-are-colocalized-and-functionally-interdependent-in-obese-zucker-rat-kidney
#19
Sanket N Patel, Quaisar Ali, Preethi Samuel, Ulrike Muscha Steckelings, Tahir Hussain
The actions of angiotensin II type 2 receptor (AT2R) and the receptor Mas (MasR) are complex but show similar pronatriuretic function; particularly, AT2R expression and natriuretic function are enhanced in obese/diabetic rat kidney. In light of some reports suggesting a potential positive interaction between these receptors, we tested hypothesis that renal AT2R and MasR physically interact and are interdependent to stimulate cell signaling and promote natriuresis in obese rats. We found that infusion of AT2R agonist C21 in obese Zucker rats (OZR) increased urine flow and urinary Na excretion which were attenuated by simultaneous infusion of the AT2R antagonist PD123319 or the MasR antagonist A-779...
August 21, 2017: Hypertension
https://www.readbyqxmd.com/read/28827413/differential-regulation-of-pro-inflammatory-cytokine-signalling-by-ptps-in-pancreatic-%C3%AE-cells
#20
William J Stanley, Prerak M Trivedi, Andrew P Sutherland, Helen Thomas, Esteban N Gurzov
Type 1 diabetes (T1D) is characterized by the destruction of insulin-producing β-cells by immune cells in the pancreas. Pro-inflammatory including TNF-α, IFN-γ and IL-1β are released in the islet during the autoimmune assault and signal in β-cells through phosphorylation cascades, resulting in pro-apoptotic gene expression and eventually β-cell death. Protein tyrosine phosphatases (PTPs) are a family of enzymes that regulate phosphorylative signalling, and are associated with the development of T1D. Here, we observed expression of PTPN6 and PTPN1 in human islets and islets from non-obese diabetic (NOD) mice...
August 21, 2017: Journal of Molecular Endocrinology
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