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https://www.readbyqxmd.com/read/29340061/analysis-of-the-mutational-landscape-of-classic-hodgkin-lymphoma-identifies-disease-heterogeneity-and-potential-therapeutic-targets
#1
Elena Mata, Antonio Díaz-López, Ana M Martín-Moreno, Margarita Sánchez-Beato, Ignacio Varela, María J Mestre, Carlos Santonja, Fernando Burgos, Javier Menárguez, Mónica Estévez, Mariano Provencio, Beatriz Sánchez-Espiridión, Eva Díaz, Carlos Montalbán, Miguel A Piris, Juan F García
Defining the mutational landscape of classic Hodgkin lymphoma is still a major research goal. New targeted next-generation sequencing (NGS) techniques may identify pathogenic mechanisms and new therapeutic opportunities related to this disease. We describe the mutational profile of a series of 57 cHL cases, enriched in Hodgkin and Reed-Sternberg (HRS) cells. Overall, the results confirm the presence of strong genomic heterogeneity. However, several variants were consistently detected in genes related to relevant signaling pathways, such as GM-CSF/IL-3, CBP/EP300, JAK/STAT, NF-kappaB, and numerous variants of genes affecting the B-cell receptor (BCR) pathway, such as BTK, CARD11, BCL10, among others...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29315242/nf-kappab-two-sides-of-the-same-coin
#2
REVIEW
Bruno R B Pires, Rafael C M C Silva, Gerson M Ferreira, Eliana Abdelhay
Nuclear Factor-kappa B (NF-κB) is a transcription factor family that regulates a large number of genes that are involved in important physiological processes, including survival, inflammation, and immune responses. More recently, constitutive expression of NF-κB has been associated with several types of cancer. In addition, microorganisms, such as viruses and bacteria, cooperate in the activation of NF-κB in tumors, confirming the multifactorial role of this transcription factor as a cancer driver. Recent reports have shown that the NF-κB signaling pathway should receive attention for the development of therapies...
January 9, 2018: Genes
https://www.readbyqxmd.com/read/29251177/co-expression-of-rela-p65-and-actn4-induces-apoptosis-in-non-small-lung-carcinoma-cells
#3
Ekaterina Lomert, Lidia Turoverova, Daria Kriger, Nikolai D Aksenov, Alina D Nikotina, Alexey Petukhov, Alexey G Mittenberg, Nikolai V Panyushev, Mikhail Khotin, Kirill Volkov, Nikolai A Barlev, Dmitri Tentler
Alpha-actinin 4 (ACTN4) is an actin-binding protein of the spectrin superfamily. ACTN4 is found both in the cytoplasm and nucleus of eukaryotic cells. The main function of cytoplasmic ACTN4 is stabilization of actin filaments and their binding to focal contacts. Nuclear ACTN4 takes part in the regulation of gene expression following by activation of certain transcription factors, but the mechanisms of regulation are not completely understood. Our previous studies have demonstrated the interaction of ACTN4 with the RelA/p65 subunit of NF-kappaB factor and the effect on its transcriptional activity in A431 and HEK293T cells...
December 17, 2017: Cell Cycle
https://www.readbyqxmd.com/read/29235580/corrigendum-interleukin-7-induces-osteoclast-formation-via-stat5-independent-of-receptor-activator-of-nf-kappab-ligand
#4
Jin-Hee Kim, Ji Hyun Sim, Sunkyung Lee, Min A Seol, Sang-Kyu Ye, Hyun Mu Shin, Eun Bong Lee, Yun Jong Lee, Yun Jung Choi, Wan-Hee Yoo, Jin Hyun Kim, Wan-Uk Kim, Dong-Sup Lee, Jin-Hong Kim, Insoo Kang, Seong Wook Kang, Hang-Rae Kim
[This corrects the article on p. 1376 in vol. 8, PMID: 29104576.].
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29226261/coordination-of-early-cellular-reactions-during-activation-of-bone-resorption-in-the-rat-mandible-periosteum-an-immunohistochemical-study
#5
Bassam Hassan, Isabelle Fouilloux, Brigitte Baroukh, Annie Llorens, Martin Biosse Duplan, Marjolaine Gosset, Marc Cherruau, Jean-Louis Saffar
The activation step of bone remodeling remains poorly characterized. Activation comprises determination of the site to be remodeled, osteoclast precursor recruitment, their migration to the site of remodeling, and differentiation. These actions involve different compartments and cell types. The aim of this study was to investigate events and cell types involved during activation. We used a bone remodeling model in rats where extractions of the upper jaw molars initiate remodeling of the antagonist lower jaw (mandible) cortex along the periosteum...
October 2017: Heliyon
https://www.readbyqxmd.com/read/29212296/immune-enhancement-effect-of-asterias-amurensis-fatty-acids-through-nf-kappab-and-mapk-pathways-on-raw-264-7-cells
#6
Chaiwat Monmai, Seok Hyeon Go, Il-Sik Shin, SangGuan You, Hyungjae Lee, SeokBeom Kang, Woo Jung Park
Asterias amurensis is a marine organism that causes damage to the fishing industry worldwide; however, it has been considered a promising source of functional components. The present study aimed to investigate the immune-enhancing effects of fatty acids from three organs of A. amurensis on murine macrophages (RAW 264.7 cells). A. amurensis fatty acids boosted production of immune-associated factors such as nitric oxide (NO) and prostaglandin E2 in RAW 264.7 cells. A. amurensis fatty acids also enhanced expression of critical immune-associated genes, including iNOS, TNF-α, IL-1β, and IL-6, as well as COX-2...
December 8, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29186820/integrative-bioinformatic-analysis-of-transcriptomic-data-identifies-conserved-molecular-pathways-underlying-ionizing-radiation-induced-bystander-effects-ribe
#7
(no author information available yet)
Ionizing radiation-induced bystander effects (RIBE) encompass a number of effects with potential for a plethora of damages in adjacent non-irradiated tissue. The cascade of molecular events is initiated in response to the exposure to ionizing radiation (IR), something that may occur during diagnostic or therapeutic medical applications. In order to better investigate these complex response mechanisms, we employed a unified framework integrating statistical microarray analysis, signal normalization, and translational bioinformatics functional analysis techniques...
November 25, 2017: Cancers
https://www.readbyqxmd.com/read/29185982/adrenergic-regulation-during-acute-hepatic-infection-with-entamoeba-histolytica-in-the-hamster-involvement-of-oxidative-stress-nrf2-and-nf-kappab
#8
Liseth Rubi Aldaba-Muruato, Martín Humberto Muñoz-Ortega, José Roberto Macías-Pérez, Julieta Pulido-Ortega, Sandra Luz Martínez-Hernández, Javier Ventura-Juárez
Oxidative stress and transcriptional pathways of nuclear factor erythroid 2-related factor 2 (Nrf2) and nuclear factor kappa-B (NF-κB) are critically involved in the etiopathology of amebic liver abscess (ALA). In this work, we studied the relationship between the adrenergic nervous system and ALA in the hamster. ALA was visible at 12 h of infection. While 6-hydroxidopamine (6-OHDA) decreased infection, propranolol (β-adrenergic blocker) treatment was associated with less extensive liver damage, and phentolamine treatment (α-adrenergic blocker) significantly reduced ALA compared to 6-OHDA and propranolol...
2017: Parasite: Journal de la Société Française de Parasitologie
https://www.readbyqxmd.com/read/29176876/neuroprotection-and-neuroregeneration-of-retinal-ganglion-cells-after-intravitreal-carbon-monoxide-release
#9
Julia Stifter, Felix Ulbrich, Ulrich Goebel, Daniel Böhringer, Wolf Alexander Lagrèze, Julia Biermann
PURPOSE: Retinal ischemia induces apoptosis leading to neurodegeneration and vision impairment. Carbon monoxide (CO) in gaseous form showed cell-protective and anti-inflammatory effects after retinal ischemia-reperfusion-injury (IRI). These effects were also demonstrated for the intravenously administered CO-releasing molecule (CORM) ALF-186. This article summarizes the results of intravitreally released CO to assess its suitability as a neuroprotective and neuroregenerative agent. METHODS: Water-soluble CORM ALF-186 (25 μg), PBS, or inactivated ALF (iALF) (all 5 μl) were intravitreally applied into the left eyes of rats directly after retinal IRI for 1 h...
2017: PloS One
https://www.readbyqxmd.com/read/29170022/functional-analysis-of-the-promoter-of-the-molt-inhibiting-hormone-mih-gene-in-mud-crab-scylla-paramamosain
#10
Xin Zhang, Danping Huang, Xiwei Jia, Zhihua Zou, Yilei Wang, Ziping Zhang
In this study, the 5'-flanking region of molt-inhibiting hormone (MIH) gene was cloned by Tail-PCR. It is 2024 bp starting from the translation initiation site, and 1818 bp starting from the predicted transcription start site. Forecast analysis results by the bioinformatics software showed that the transcription start site is located at 207 bp upstream of the start codon ATG, and TATA box is located at 240 bp upstream of the start codon ATG. Potential transcription factor binding sites include Sp1, NF-1, Oct-1, Sox-2, RAP1, and so on...
November 20, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29162545/gene-expression-analysis-of-ruditapes-philippinarum-haemocytes-after-experimental-perkinsus-olseni-zoospore-challenge-and-infection-in-the-wild
#11
Abul Farah Md Hasanuzzaman, Juan Andrés Rubiolo, Diego Robledo, Antonio Gómez-Tato, José Antonio Álvarez-Dios, Sergio Fernández-Boo, Asunción Cao, Antonio Villalba, Belén G Pardo, Paulino Martínez
The production of Manila clam (Ruditapes philippinarum) is seriously threatened by the protistan parasite Perkinsus olseni. We characterized and compared gene expression of Manila clam haemocytes in response to P. olseni in a time-course (10 h, 24 h, 8 d) controlled laboratory challenge (LC), representing the first step of infection, and in a more complex infection in the wild (WI), using a validated oligo-microarray containing 11,232 transcripts, mostly annotated. Several immune-genes involved in NIK/NF-kappaB signalling, Toll-like receptor signalling and apoptosis were activated at LC-10 h...
November 18, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29122838/soluble-cd80-protein-delays-tumor-growth-and-promotes-tumor-infiltrating-lymphocytes
#12
Lucas A Horn, Tiha M Long, Ryan Atkinson, Virginia Clements, Suzanne Ostrand-Rosenberg
Tumor cells employ various immune suppressive strategies to overcome antitumor immunity. One such method is tumor expression of programmed death ligand-1 (PD-L1), which triggers apoptotic death or anergy upon binding programmed death-1 (PD-1) on T cells. Our previous in vitro cellular studies with human and mouse PD-L1+ tumor cells demonstrated that a soluble form of the costimulatory molecule CD80 prevented PD-L1-mediated immune suppression and restored T-cell activation by binding PD-L1 and blocking interaction with PD-1...
November 9, 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/29104576/interleukin-7-induces-osteoclast-formation-via-stat5-independent-of-receptor-activator-of-nf-kappab-ligand
#13
Jin-Hee Kim, Ji Hyun Sim, Sunkyung Lee, Min A Seol, Sang-Kyu Ye, Hyun Mu Shin, Eun Bong Lee, Yun Jong Lee, Yun Jung Choi, Wan-Hee Yoo, Jin Hyun Kim, Wan-Uk Kim, Dong-Sup Lee, Jin-Hong Kim, Insoo Kang, Seong Wook Kang, Hang-Rae Kim
Interleukin-7 (IL-7), which is required for the development and survival of T cells in the thymus and periphery, plays a role in joint destruction. However, it remains unclear how IL-7 affects osteoclast formation. Thus, we investigated the mechanism by which IL-7 induced osteoclast formation through IL-7 receptor α (IL-7Rα) in osteoclast precursors. We cultured peripheral blood mononuclear cells or synovial fluid mononuclear cells with IL-7 in the presence or absence of an appropriate inhibitor to analyze osteoclast formation...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29101208/nf-kappab-at-the-crossroads-of-normal-mammary-gland-biology-and-the-pathogenesis-and-prevention-of-brca1-mutated-breast-cancer
#14
M A Christine Pratt, Andrea Sau, Miguel A Cabrita
Recent studies have shown that progesterone receptor (PR)-expressing cells respond to progesterone in part through the induction of the receptor activator of NF-kappaB ligand (RANKL) in which acts in a paracrine manner to induce expansion of a RANK-expressing luminal progenitor cell population. The RANK+ population in human breast tissue from carriers of BRCA1 mutations (BRCA1mut/+) as well as the luminal progenitor population in Brca1-deficient mouse mammary glands is abnormally amplified. Remarkably, mouse Brca1+/- and human BRCA1mut/+ progenitor cells are able to form colonies in vitro in the absence of progesterone demonstrating a hormone-independent proliferative capacity...
November 3, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/29098085/the-protective-effects-of-%C3%AE-b-crystallin-on-ischemia-reperfusion-injury-in-the-rat-retina
#15
Huan Yan, Yanli Peng, Wei Huang, Liyan Gong, Li Li
To investigate whether αB-crystallin protects against acute retinal ischemic reperfusion injury (I/R) and elucidate the potential antioxidant mechanisms. Retinal I/R injury was made by elevating the intraocular pressure (IOP) 110 mmHg for 60 min, and αB-crystallin (1 × 10(-5) g/L) or vehicle solution was administered intravitreously immediately after I/R injury. The animal was sacrificed 24 h, 1 w, and 1 m after the I/R injury. The retina damage was detected by hematoxylin and eosin (HE) staining and electroretinography (ERG)...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29089332/chemopreventive-and-antitumor-efficacy-of-curcumin-in-a-spontaneously-developing-hen-ovarian-cancer-model
#16
Kazim Sahin, Cemal Orhan, Mehmet Tuzcu, Nurhan Sahin, Hakki Tastan, Ibrahim Hanifi Ozercan, Osman Guler, Nermin Kahraman, Omer Kucuk, Bulent Ozpolat
We investigated the effect of daily dietary curcumin intake on the development and progression of spontaneous ovarian cancer in a galline (hen) model, as the chicken is the only nonhuman animal in which ovarian cancer spontaneously develops with a high prevalence. At the end of 12 months, ovarian cancer had spontaneously developed in 39% (35/90) of control hens not fed curcumin (n = 90). In comparison, it spontaneously developed in 27% (24/90) and 17% (15/90) of hens given curcumin at 25.8 (n=90) and 53.0 mg/day (n=90), respectively (P = 0...
October 31, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/29061028/inhibitory-effects-of-panduratin-a-on-inflammation-and-osteoclastogenesis-induced-by-periodontitis-through-inhibition-of-mapk-pathways-in-vitro
#17
Haebom Kim, Mi-Bo Kim, Changhee Kim, Jae-Kwan Hwang
Periodontitis is an inflammatory disease caused by microbial lipopolysaccharide (LPS), destroying gingival tissues and alveolar bone in the periodontium. In the present study, we evaluated the anti-inflammatory and anti-osteoclastic effects of panduratin A, a chalcone compound isolated from Boesenbergia pandurata, in human gingival fibroblast-1 (HGF-1) and RAW 264.7 cells. Treatment of panduratin A to LPS-stimulated HGF-1 significantly reduced the expression of interleukin-1β, nuclear factor-kappa B (NF-κB), subsequently leading to inhibition of matrix metalloproteinase-2 (MMP-2), and MMP-8 compared with one in LPS control (**p < 0...
October 25, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29057806/emodin-inhibition-of-influenza-a-virus-replication-and-influenza-viral-pneumonia-via-the-nrf2-tlr4-p38-jnk-and-nf-kappab-pathways
#18
Jian-Ping Dai, Qian-Wen Wang, Yun Su, Li-Ming Gu, Ying Zhao, Xiao-Xua Chen, Cheng Chen, Wei-Zhong Li, Ge-Fei Wang, Kang-Sheng Li
Lasting activations of toll-like receptors (TLRs), MAPK and NF-κB pathways can support influenza A virus (IAV) infection and promote pneumonia. In this study, we have investigated the effect and mechanism of action of emodin on IAV infection using qRT-PCR, western blotting, ELISA, Nrf2 luciferase reporter, siRNA and plaque inhibition assays. The results showed that emodin could significantly inhibit IAV (ST169, H1N1) replication, reduce IAV-induced expressions of TLR2/3/4/7, MyD88 and TRAF6, decrease IAV-induced phosphorylations of p38/JNK MAPK and nuclear translocation of NF-κB p65...
October 18, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29054963/interleukin-12-mediated-expression-of-matrix-metalloproteinases-in-human-periodontal-ligament-fibroblasts-involves-in-nf-kappab-activation
#19
Li Miao, Shujun Zhan, Jiyan Liu
Interleukin (IL-12) is a pro-inflammatory cytokine, and its increased level correlates with the severity of periodontitis. However, its role in the pathogenesis of tooth periapical lesions is controversial and has not been completely clarified. This study aimed to investigate whether IL-12 affects the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in human periodontal ligament fibroblasts (hPDLFs). After treatment with IL-12 for different time, Real-time PCR and Western blotting were used to determine the mRNA and protein levels of MMP-1, MMP-2, MMP-3, MMP-9, MMP-13, TIMP-1 and TIMP-2, respectively...
October 20, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29046352/the-lignan-manassantin-is-a-potent-and-specific-inhibitor-of-mitochondrial-complex-i-and-bioenergetic-activity-in-mammals
#20
Yibao Ma, Hae-Ki Min, Unsong Oh, Adam M Hawkridge, Wei Wang, Ahmed A Mohsin, Qun Chen, Arun Sanyal, Edward J Lesnefsky, Xianjun Fang
Dineolignans manassantin A and B from the plant Saururus cernuus are used in traditional medicine to manage a wide range of ailments such as edema, jaundice, and gonorrhea. Cell-based studies have identified several molecular target candidates of manassantin including NF-kappaB, MAPK, STAT3 and hypoxia-inducible factor 1 alpha (HIF-1alpha). It is unclear whether or how these structurally diverse proteins or pathways mediate any of the medical benefits of manassantin in vivo. Moreover, it has been recently reported that manassantin causes developmental arrest in zebrafish by inhibiting the mitochondrial complex I, but it is unknown whether manassantin inhibits mitochondrial respiration in intact mammalian cells and live animals...
October 18, 2017: Journal of Biological Chemistry
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