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https://www.readbyqxmd.com/read/28438506/diacylglycerol-kinase-%C3%AE-limits-cytokine-dependent-expansion-of-cd8-t-cells-with-broad-antitumor-capacity
#1
Elena Andrada, Rosa Liébana, Isabel Merida
Interleukin-2 and -15 drive expansion/differentiation of cytotoxic CD8(+) T cells that eliminate targets via antigen-independent killing. This property is clinically relevant for the improvement of T cell-based antitumor therapies. Diacylglycerol kinase α and ζ (DGKα/ζ) metabolize the diacylglycerol generated following antigen recognition by T lymphocytes. Enhanced expression of these two lipid kinases in tumor-infiltrating CD8(+) T cells promotes a hyporesponsive state that contributes to tumor immune escape...
April 14, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28408611/correction-for-doukas-and-sarnow-escape-from-transcriptional-shutoff-during-poliovirus-infection-nf-%C3%AE%C2%BAb-responsive-genes-i%C3%AE%C2%BAba-and-a20
#2
Tammy Doukas, Peter Sarnow
No abstract text is available yet for this article.
May 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28405612/microrna-125a-and-b-inhibit-a20-and-mavs-to-promote-inflammation-and-impair-antiviral-response-in-copd
#3
Alan C-Y Hsu, Kamal Dua, Malcolm R Starkey, Tatt-Jhong Haw, Prema M Nair, Kristy Nichol, Nathan Zammit, Shane T Grey, Katherine J Baines, Paul S Foster, Philip M Hansbro, Peter A Wark
Influenza A virus (IAV) infections lead to severe inflammation in the airways. Patients with chronic obstructive pulmonary disease (COPD) characteristically have exaggerated airway inflammation and are more susceptible to infections with severe symptoms and increased mortality. The mechanisms that control inflammation during IAV infection and the mechanisms of immune dysregulation in COPD are unclear. We found that IAV infections lead to increased inflammatory and antiviral responses in primary bronchial epithelial cells (pBECs) from healthy nonsmoking and smoking subjects...
April 6, 2017: JCI Insight
https://www.readbyqxmd.com/read/28388318/rotary-and-high-pressure-nozzle-spray-plume-droplet-analysis-for-aerially-applied-mosquito-adulticides-laser-diffraction-characterization
#4
Jonathan A Hornby, Jim Robinson, Milton Sterling
The droplet spectrum of a mosquito adulticide spray plume determines its ability to drift through the target area, impinge on the mosquito, deliver a toxic dose, and the risk of environmental contamination. This paper provides data on droplet spectra produced from 6 nozzles in a high-pressure nozzle spray system and 5 rotary nozzle systems for common mosquito adulticides. Spray plume spectra were measured by laser diffraction. High-pressure nozzles were evaluated at pressures ranging from 500 psi to 6,000 psi...
March 2017: Journal of the American Mosquito Control Association
https://www.readbyqxmd.com/read/28382901/uterus-like-masses-in-a-rhesus-macaque-macaca-mulatta
#5
Mary F Dickerson, Lauren D Martin, Anne D Lewis
Endometriosis is a relatively common condition in women and some populations of adult female rhesus macaques. However,endometriosis with extensive smooth muscle proliferation, as occurs in endomyometrioma and uterus-like mass (ULM), is rare inwomen. This report describes a case of endometriosis with extensive smooth muscle metaplasia resembling multiple ULM in a20-y-old female rhesus macaque. During a protocol-related procedure, a large, smooth, globoid, freely moveable mass was palpated in the midabdomen. Ultrasonography revealed a cystic structure from which dark brown fluid was aspirated...
April 5, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/28379950/computation-and-measurement-of-cell-decision-making-errors-using-single-cell-data
#6
Iman Habibi, Raymond Cheong, Tomasz Lipniacki, Andre Levchenko, Effat S Emamian, Ali Abdi
In this study a new computational method is developed to quantify decision making errors in cells, caused by noise and signaling failures. Analysis of tumor necrosis factor (TNF) signaling pathway which regulates the transcription factor Nuclear Factor κB (NF-κB) using this method identifies two types of incorrect cell decisions called false alarm and miss. These two events represent, respectively, declaring a signal which is not present and missing a signal that does exist. Using single cell experimental data and the developed method, we compute false alarm and miss error probabilities in wild-type cells and provide a formulation which shows how these metrics depend on the signal transduction noise level...
April 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28363868/neoagarooligosaccharides-prevent-septic-shock-by-modulating-a20-and-cyclooxygenase-2-mediated-interleukin-10-secretion-in-a-septic-shock-mouse-model
#7
Da Rae Kang, Gun Young Yoon, Joon Cho, Seung Jun Lee, Su Jin Lee, Hee Jo Park, Tae Heung Kang, Hee Dong Han, Won Sun Park, Young Kyung Yoon, Yeong-Min Park, In Duk Jung
Analysis of the signaling mechanism triggered by endotoxin-mediated toll-like receptor-4 activation using immune cell systems or rodent models may help identify potential agents for the prevention of Gram-negative bacteria infection. β-agarase cleaves the β-1,4-linkages of agar to produce neoagarooligosaccharides (NAOs), which have various physiological functions. The aim of this study was to investigate the efficacy of NAOs in preventing experimental sepsis caused by the administration of endotoxin or Gram-negative bacteria...
May 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28362430/cyld-a20-and-otulin-deubiquitinases-in-nf-%C3%AE%C2%BAb-signaling-and-cell-death-so-similar-yet-so-different
#8
REVIEW
Marie Lork, Kelly Verhelst, Rudi Beyaert
Polyubiquitination of proteins has a pivotal role in the regulation of numerous cellular functions such as protein degradation, DNA repair and cell signaling. As deregulation of these processes can result in pathological conditions such as inflammatory diseases, neurodegeneration or cancer, tight regulation of the ubiquitin system is of tremendous importance. Ubiquitination by E3 ubiquitin ligases can be counteracted by the activity of several deubiquitinating enzymes (DUBs). CYLD, A20 and OTULIN have been implicated as key DUBs in the negative regulation of NF-κB transcription factor-mediated gene expression upon stimulation of cytokine receptors, antigen receptors and pattern recognition receptors, by removing distinct types of polyubiquitin chains from specific NF-κB signaling proteins...
March 31, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28355611/the-effects-of-mir-136-5p-mediated-regulation-of-a20-in-astrocytes-from-cultured-spinal-cord-cultured-cells-in-vitro
#9
Xiaoming Peng, Xiongzhi Shi, Jinmin Zhao, Jichen He, Keke Li, Zhongxi Cen, Yunle Wu, Shaohui Zong, Gaofeng Zeng
BACKGROUND/AIMS: This study focused on investigating the regulatory mechanism of miR-136-5p in mouse astrocytes stimulated with interleukin-17(IL-17). METHODS: C57BL/6 mouse astrocytes were stimulated with IL-17 (100ng/ml) for various periods of time (0-48 hours) and at various doses (0-200 ng), and the expression levels of inflammatory cytokine and chemokine genes (IL-6, TNF-α, MCP-1, MCP-5 and MIP-2) were then detected by real-time PCR. The expression of the A20 gene was measured with real-time PCR in cells that were stimulated with IL-17 (50 ng/ml) for various periods of time (0-48 hours)...
March 28, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28355270/the-nf-%C3%AE%C2%BAb-dependent-and-independent-transcriptome-and-chromatin-landscapes-of-human-coronavirus-229e-infected-cells
#10
Michael Poppe, Sascha Wittig, Liane Jurida, Marek Bartkuhn, Jochen Wilhelm, Helmut Müller, Knut Beuerlein, Nadja Karl, Sabin Bhuju, John Ziebuhr, M Lienhard Schmitz, Michael Kracht
Coronavirus replication takes place in the host cell cytoplasm and triggers inflammatory gene expression by poorly characterized mechanisms. To obtain more insight into the signals and molecular events that coordinate global host responses in the nucleus of coronavirus-infected cells, first, transcriptome dynamics was studied in human coronavirus 229E (HCoV-229E)-infected A549 and HuH7 cells, respectively, revealing a core signature of upregulated genes in these cells. Compared to treatment with the prototypical inflammatory cytokine interleukin(IL)-1, HCoV-229E replication was found to attenuate the inducible activity of the transcription factor (TF) NF-κB and to restrict the nuclear concentration of NF-κB subunits by (i) an unusual mechanism involving partial degradation of IKKβ, NEMO and IκBα and (ii) upregulation of TNFAIP3 (A20), although constitutive IKK activity and basal TNFAIP3 expression levels were shown to be required for efficient virus replication...
March 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28353147/bioconversion-of-lutein-by-enterobacter-hormaechei-to-form-a-new-compound-8-methyl-%C3%AE-ionone
#11
Guifang Zhong, Fangfang Wang, Jianhong Sun, Jianbin Ye, Duobin Mao, Ke Ma, Xuepeng Yang
OBJECTIVES: To investigate the final product of the bioconversion of lutein by a novel lutein-degrading bacterium, Enterobacter hormaechei A20, and the kinetics of the process. RESULTS: A new product, 8-methyl-α-ionone, was resolved by GC-MS. The compound was further identified by NMR. A conversion yield of 90% was achieved by E. hormaechei in 36 h with 10 g lutein l(-1). CONCLUSIONS: This is the first report of the bioconversion of lutein to form 8-methyl-α-ionone...
March 28, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28352315/daphnetin-inhibits-inflammation-in-the-nzb-w-f1-systemic-lupus-erythematosus-murine-model-via-inhibition-of-nf-%C3%AE%C2%BAb-activity
#12
Min Li, Xiaowei Shi, Fangru Chen, Fei Hao
Daphnetin is a compound extracted from Chinese medicinal herbs, which exerts analgesic and anti-inflammatory effects. The present study aimed to investigate the potential therapeutic effect of daphnetin on inflammation in the NZB/W F1 systemic lupus erythematosus (SLE) murine model. Female NZB/WF1 mice (age, 16-18 weeks) were intraperitoneally injected with daphnetin once a day for 12 weeks. It was revealed that daphnetin treatment significantly increased animal survival rates, reduced renal damage and blood urea nitrogen levels, and suppressed serum autoantibody production in the SLE-prone NZB/W F1 mice...
February 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28337659/a20-in-multiple-sclerosis-and-parkinson-s-disease-clue-to-a-common-dysregulation-of-anti-inflammatory-pathways
#13
Simona Perga, Serena Martire, Francesca Montarolo, Nicole D Navone, Andrea Calvo, Giuseppe Fuda, Alberto Marchet, Daniela Leotta, Adriano Chiò, Antonio Bertolotto
Chronic inflammation significantly contributes to the pathogenesis of several neurodegenerative disorders. In physiological conditions, a chronic inflammatory state is prevented through the termination of the acute inflammatory response once the triggering insult is eliminated. Several mechanisms regulate the resolution of inflammation. Among these, a potent inhibitor of the pro-inflammatory NF-kB signaling known as A20 has emerged as a key player. Recent studies have shown reduced blood levels of A20 in the patients of diverse chronic inflammatory diseases...
March 23, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28336950/dual-regulation-of-water-retention-and-cell-growth-by-a-stress-associated-protein-sap-gene-in-prunus
#14
Alba Lloret, Ana Conejero, Carmen Leida, César Petri, Francisco Gil-Muñoz, Lorenzo Burgos, María Luisa Badenes, Gabino Ríos
We have identified a gene (PpSAP1) of Prunus persica coding for a stress-associated protein (SAP) containing Zn-finger domains A20 and AN1. SAPs have been described as regulators of the abiotic stress response in plant species, emerging as potential candidates for improvement of stress tolerance in plants. PpSAP1 was highly expressed in leaves and dormant buds, being down-regulated before bud dormancy release. PpSAP1 expression was moderately induced by water stresses and heat in buds. In addition, it was found that PpSAP1 strongly interacts with polyubiquitin proteins in the yeast two-hybrid system...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28336533/critical-residues-and-motifs-for-homodimerization-of-the-first-transmembrane-domain-of-the-plasma-membrane-glycoprotein-cd36
#15
Peng Wei, Fu-de Sun, Li-Min Zuo, Jing Qu, Peng Chen, Li-da Xu, Shi-Zhong Luo
The plasma transmembrane (TM) glycoprotein CD36 is critically involved in many essential signaling processes, especially the binding /uptake of long-chain fatty acids and oxidized low-density lipoproteins. The association of CD36 potentially activates cytosolic protein tyrosine kinases that are thought to associate with the C-terminal cytoplasmic tail of CD36. To understand the mechanisms by which CD36 mediates ligand binding and signal transduction, we have characterized the homo- oligomeric interaction of CD36 TM domains in membrane environments and with molecular dynamics (MD) simulations...
March 23, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28296250/different-genetic-alteration-of-a20-in-a-s%C3%A3-zary-syndrome-case-with-v%C3%AE-2-j%C3%AE-22-t-cell-clone
#16
Lingling Zhou, Haitao Zheng, Xin Huang, Lihua Zhu, Suijing Wu, Chengwu Zeng, Lijian Yang, Shaohua Chen, Gengxin Luo, Xin Du, Yangqiu Li
BACKGROUND: The comprehensive genetic alterations underlying the pathogenesis of Sézary syndrome (SS) remains largely unknown. Previous studies showed that alterations of tumor necrosis factor-α-induced protein 3 gene (TNFAIP3; A20) are frequent in SS. In this study, we characterized the mutation and polymorphisms of A20 in a case with SS and compared with the genetic feature of A20 in T-cell acute lymphoblastic leukemia (T-ALL). METHODS: Using a novel approach based on the combination of fine-tiling array comparative genomic hybridization ( and ligation-mediated polymerase chain reaction (LM-PCR) to identify SS clone, the polymorphisms in the A20 gene (promoter, exons 2-9 [coding region] and 3'UTR) were detected by PCR and sequencing...
March 14, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28288707/malt-lymphoma-genetic-abnormalities-immunological-stimulation-and-molecular-mechanism
#17
REVIEW
Ming-Qing Du
Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) occurs at diverse anatomic sites and is closely associated with several distinct chronic inflammatory disorders. Both the acquired genetic abnormalities and active chronic immunological responses play a critical role in the development of MALT lymphoma, interestingly by dysregulating similar molecular mechanisms. The three translocations seen in MALT lymphoma, namely t(14;18)(q32;q21)/IGH-MALT1, t(1;14)(p22;q32)/BCL10-IGH, and t(11;18)(q21;q21)/BIRC3 (API2)-MALT1 are capable of activating both canonical and non-canonical NF-κB pathways...
March 2017: Best Practice & Research. Clinical Haematology
https://www.readbyqxmd.com/read/28276730/platelet-reactivity-in-thromboelastometry-revision-of-the-fibtem-test-a-basic-study
#18
Grzegorz Biolik, Michał Kokot, Mariola Sznapka, Agnieszka Święszek, Damian Ziaja, Krzysztof Pawlicki, Krzysztof Ziaja
This study aimed to investigate modifications to the FIBTEM test to better assess fibrinogen levels and the quality of fibrin polymerization in citrated blood using Multiplate impedance aggregometry to verify platelet inhibition. Blood samples from 26 healthy volunteers were subjected to thromboelastometry studies (EXTEM/FIBTEM tests) in accordance with the standard study protocol (cytochalasin D) and according to a modified protocol (synthetic IIbIIIa receptor antagonist vs. acetylsalicylic acid [ASA] + synthetic IIbIIIa receptor antagonist instead of cytochalasin D)...
May 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28251449/a20-attenuates-liver-fibrosis-in-nafld-and-inhibits-inflammation-responses
#19
Xiaohan Wang, Luoyan Ai, Qingqing Xu, Changwei Wu, Zhiwei Chen, Dazhi Su, Xiaoke Jiang, Zhuping Fan
We previously reported A20 was able to inhibit lipid accumulation in nonalcoholic steatohepatitis. We want to investigate whether A20 influences liver fibrosis in this study. Liver tissues from patients with hepatic fibrosis (n = 9) and healthy individuals (n = 7) were studied for A20 protein level by immunohistochemistry. A20 messenger RNA (mRNA) and protein level were also analyzed in two murine hepatic fibrosis models: methionine- and choline-deficient (MCD) diet and extrahepatic bile duct ligation (BDL) operation by real-time PCR and western blot...
March 1, 2017: Inflammation
https://www.readbyqxmd.com/read/28240686/sepsis-patients-display-a-reduced-capacity-to-activate-nuclear-factor-%C3%AE%C2%BAb-in-multiple-cell-types
#20
Arie J Hoogendijk, M Isabel Garcia-Laorden, Lonneke A van Vught, Maryse A Wiewel, Hakima Belkasim-Bohoudi, JanWillem Duitman, Janneke Horn, Marcus J Schultz, Brendon P Scicluna, Cornelis van 't Veer, Alex F de Vos, Tom van der Poll
OBJECTIVES: Sepsis is a complex clinical condition associated with high morbidity and mortality. A distinctive feature of sepsis is the reduced capacity of leukocytes to release proinflammatory cytokines in response to ex vivo stimulation. Cellular signaling events leading to immunosuppression in sepsis are not well defined. We investigated cell-specific signaling events underlying the immunosuppressed phenotype in sepsis. DESIGN: Ex vivo study. SETTING: ICU of an academic hospital...
May 2017: Critical Care Medicine
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