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https://www.readbyqxmd.com/read/29778854/proposed-stages-of-myocardial-phenotype-development-in-fabry-disease
#1
Sabrina Nordin, Rebecca Kozor, Katia Medina-Menacho, Amna Abdel-Gadir, Shanat Baig, Daniel M Sado, Ilaria Lobascio, Elaine Murphy, Robin H Lachmann, Atul Mehta, Nicola C Edwards, Uma Ramaswami, Richard P Steeds, Derralynn Hughes, James C Moon
OBJECTIVES: The authors sought to explore the Fabry myocardium in relation to storage, age, sex, structure, function, electrocardiogram changes, blood biomarkers, and inflammation/fibrosis. BACKGROUND: Fabry disease (FD) is a rare, x-linked lysosomal storage disorder. Mortality is mainly cardiovascular with men exhibiting cardiac symptoms earlier than women. By cardiovascular magnetic resonance, native T1 is low in FD because of sphingolipid accumulation. METHODS: A prospective, observational study of 182 FD (167 adults, 15 children; mean age 42 ± 17 years, 37% male) who underwent cardiovascular magnetic resonance including native T1, late gadolinium enhancement (LGE), and extracellular volume fraction, 12-lead electrocardiogram, and blood biomarkers (troponin and N-terminal pro-brain natriuretic peptide)...
May 11, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29777548/higher-contact-force-during-radiofrequency-ablation-leads-to-a-much-larger-increase-in-edema-as-compared-to-chronic-lesion-size
#2
Samuel Thomas, Josh Silvernagel, Nathan Angel, Eugene Kholmovski, Elyar Ghafoori, Nan Hu, John Ashton, Derek J Dosdall, Rob MacLeod, Ravi Ranjan
INTRODUCTION: Reversible edema is a part of any radiofrequency ablation but its relationship with contact force is unknown. The goal of this study was to characterize through histology and MRI, acute and chronic ablation lesions and reversible edema with contact force. METHODS AND RESULTS: In a canine model (n = 14), chronic ventricular lesions were created with a 3.5 mm tip ThermoCool SmartTouch (Biosense Webster) catheter at 25W or 40W for 30 sec. Repeat ablation was performed after 3 months to create a second set of lesions (acute)...
May 18, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29764898/clinical-presentation-and-outcome-in-a-contemporary-cohort-of-patients-with-acute-myocarditis-the-multicenter-lombardy-registry
#3
Enrico Ammirati, Manlio Cipriani, Claudio Moro, Claudia Raineri, Daniela Pini, Paola Sormani, Riccardo Mantovani, Marisa Varrenti, Patrizia Pedrotti, Cristina Conca, Antonio Mafrici, Aurelia Grosu, Daniele Briguglia, Silvia Guglielmetto, Giovanni Battista Perego, Stefania Colombo, Salvatore Ivan Caico, Cristina Giannattasio, Alberto Maestroni, Valentina Carubelli, Marco Metra, Carlo Lombardi, Jeness Campodonico, Piergiuseppe Agostoni, Giovanni Peretto, Laura Scelsi, Annalisa Turco, Giuseppe Di Tano, Carlo Campana, Armando Belloni, Fabrizio Morandi, Andrea Mortara, Antonio Cirò, Michele Senni, Antonello Gavazzi, Maria Frigerio, Fabrizio Oliva, Paolo G Camici
Background -There is controversy regarding outcome of patients with acute myocarditis (AM), and lack of data on how patients admitted with suspected AM are managed. We report characteristics, in-hospital management and long-term outcome of patients with AM based on a retrospective multi-center registry from 19 Italian hospitals. Methods -A total of 684 patients with suspected AM and recent onset of symptoms (<30 days) were screened between May 2001 and February 2017. Patients >70 years and those older than 50 years without coronary angiography were excluded...
May 15, 2018: Circulation
https://www.readbyqxmd.com/read/29759774/assessment-of-left-atrial-fibrosis-by-late-gadolinium-enhancement-magnetic-resonance-imaging-methodology-and-clinical-implications
#4
REVIEW
Johannes Siebermair, Eugene G Kholmovski, Nassir Marrouche
Recently, studies using late gadolinium enhancement (LGE) magnetic resonance imaging (MRI) to identify structural changes of atrial tissue have contributed significantly to understanding the pathophysiology and progression of atrial fibrillation (AF). Moreover, imaging of atrial fibrosis using MRI has evolved to be a tool to improve clinical outcome of AF ablation procedures by allowing a patient-specific individualized management approach. LGE-MRI has been shown to predict AF ablation outcome based on pre-procedural imaging to define the extent of atrial fibrosis...
August 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29754182/assessment-of-aortic-stiffness-in-patients-with-ankylosing-spondylitis-using-cardiovascular-magnetic-resonance
#5
P Stefan Biesbroek, Sjoerd C Heslinga, Peter M van de Ven, Mike J L Peters, Raquel P Amier, Thelma C Konings, Christopher D Maroules, Colby Ayers, Parag H Joshi, Irene E van der Horst-Bruinsma, Vokko P van Halm, Albert C van Rossum, Michael T Nurmohamed, Robin Nijveldt
To evaluate aortic stiffness in patients with ankylosing spondylitis (AS) using cardiovascular magnetic resonance (CMR) and to assess its association with AS characteristics and left ventricular (LV) remodeling. In this prospective study, 14 consecutive AS patients were each matched to two controls without cardiovascular symptoms or known cardiovascular disease who underwent CMR imaging for the assessment of aortic arch pulse wave velocity (PWV) at 1.5 Tesla. To enhance comparability of the samples, matching was done with replacement resulting in 20 unique controls...
May 12, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29754161/motion-corrected-whole-heart-pet-mr-for-the-simultaneous-visualisation-of-coronary-artery-integrity-and-myocardial-viability-an-initial-clinical-validation
#6
Camila Munoz, Karl P Kunze, Radhouene Neji, Teresa Vitadello, Christoph Rischpler, René M Botnar, Stephan G Nekolla, Claudia Prieto
PURPOSE: Cardiac PET-MR has shown potential for the comprehensive assessment of coronary heart disease. However, image degradation due to physiological motion remains a challenge that could hinder the adoption of this technology in clinical practice. The purpose of this study was to validate a recently proposed respiratory motion-corrected PET-MR framework for the simultaneous visualisation of myocardial viability (18 F-FDG PET) and coronary artery anatomy (coronary MR angiography, CMRA) in patients with chronic total occlusion (CTO)...
May 12, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29750182/the-interaction-of-qrs-duration-with-cardiac-magnetic-resonance-derived-scar-and-mechanical-dyssynchrony-in-systolic-heart-failure-implications-for-cardiac-resynchronization-therapy
#7
Tom Jackson, Sana Amraoui, Manav Sohal, Eva Sammut, Jonathan M Behar, Simon Claridge, Jessica Webb, Ben Sienecwicz, Reza Razavi, Christopher Aldo Rinaldi, Gerald Carr-White
Background: Trials using echocardiographic mechanical dyssynchrony (MD) parameters in narrow QRS patients have shown a negative response to CRT. We hypothesized MD in these patients may relate to myocardial scar rather than electrical dyssynchrony. Methods: We determined the prevalence of cardiac magnetic resonance (CMR) derived measures of MD in 130 systolic heart failure patients with both broad (≥ 130 ms - BQRS) and narrow QRS duration (< 130 ms - NQRS)...
March 2018: IJC Heart & Vasculature
https://www.readbyqxmd.com/read/29747127/wideband-lge-mri-permits-unobstructed-viewing-of-myocardial-scarring-in-a-patient-with-an-mr-conditional-subcutaneous-implantable-cardioverter-defibrillator
#8
Amir Ali Rahsepar, Jeremy D Collins, Bradley P Knight, KyungPyo Hong, James C Carr, Daniel Kim
A subcutaneous implantable cardioverter-defibrillator (S-ICD) is an alternative device for prevention of sudden cardiac death, without any leads within the heart. Patients implanted with any type of ICD may need catheter ablation of ventricular tachycardia (VT) to reduce the overall arrhythmia burden (e.g., recurrent monomorphic VT) and lower the incidence of painful shocks induced by the device. Late gadolinium enhancement (LGE) MRI is a useful pre-test for guiding VT ablation, because it can be used to map myocardial scar and produce better outcomes...
May 4, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29743511/detection-of-recent-myocardial-infarction-using-native-t1-mapping-in-a-swine-model-a-validation-study
#9
Chen Cui, Shuli Wang, Minjie Lu, Xuejing Duan, Hongyue Wang, Liujun Jia, Yue Tang, Arlene Sirajuddin, Sanjay K Prasad, Peter Kellman, Andrew E Arai, Shihua Zhao
Late gadolinium enhancement (LGE) imaging is the currently the gold standard for in-vivo detection of myocardial infarction. However, gadolinium contrast administration is contraindicated in patients with renal insufficiency. We aim to evaluate the diagnostic sensitivity and specificity of this contrast-free MRI technique, native T1 mapping, in detecting recent myocardial infarction versus a reference histological gold standard. Ten pigs underwent CMR at 2 weeks after induced MI. The infarct size and transmural extent of MI was calculated using native T1 maps and LGE images...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29743457/-multiple-hepatic-sclerosed-hemangiomas-that-are-difficult-to-diagnose-preoperatively-a-case-report
#10
Yu Hada, Shintaro Takaki, Yasuyuki Aisaka, Yohji Honda, Nami Mori, Keiji Tsuji, Megumu Fujiwara, Takashi Maeda, Yoshinari Furukawa, Kazuaki Chayama
An 83-year-old woman was admitted to our hospital because of a space-occupying lesion (SOL) in the liver. Enhanced computed tomography (CT) showed a nodule measuring 20mm in size in the posterosuperior segment of the right hepatic lobe (S7) and another nodule measuring 14mm in size in the anterosuperior segment of the right hepatic lobe (S8). The margins of these nodules showed faint enhancement in the arterial phase and presented as low-density areas in the equilibrium phase. The S8 SOL could not be easily identified using ultrasonography (US)...
2018: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/29737871/circulating-biomarkers-of-hypertrophy-and-fibrosis-in-patients-with-hypertrophic-cardiomyopathy-assessed-by-cardiac-magnetic-resonance
#11
Monika Gawor, Mateusz Śpiewak, Agata Kubik, Aleksandra Wróbel, Anna Lutyńska, Magdalena Marczak, Jacek Grzybowski
PURPOSE: Myocardial fibrosis in hypertrophic cardiomyopathy (HCM) is associated with worse clinical outcomes. The availability of circulating biomarkers of myocardial fibrosis and hypertrophy would be helpful in clinical practice. METHODS: Levels of biomarkers: soluble ST2 (sST2), galectin-3, growth differentiation factor-15 (GDF-15), NT-proBNP, and high-sensitivity cardiac troponin T (hs-cTnT) were measured in 60 patients with HCM. All patients underwent cardiac magnetic resonance imaging to calculate parameters of hypertrophy and fibrosis...
May 8, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29735362/mri-with-gadofosveset-a-potential-marker-for-permeability-in-myocardial-infarction
#12
Begoña Lavin, Andrea Protti, Silvia Lorrio, Xuebin Dong, Alkystis Phinikaridou, René M Botnar, Ajay Shah
BACKGROUND AND AIMS: Acute ischemia is associated with myocardial endothelial damage and microvessel formation, resulting in leakage of plasma albumin into the myocardial extravascular space. In this study, we tested whether an albumin-binding intravascular contrast agent (gadofosveset) allows for improved quantification of myocardial permeability compared to the conventional extracellular contrast agent Gd-DTPA using late gadolinium enhancement (LGE) and T1 mapping in vivo. METHODS: MI was induced in C57BL/6 mice (n = 6) and cardiac magnetic resonance imaging (CMR) was performed at 3, 10 and 21 days post-MI using Gd-DTPA and 24 h later using gadofosveset...
April 25, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29734489/diagnostic-performance-of-intravoxel-incoherent-motion-diffusion-weighted-imaging-in-the-assessment-of-the-dynamic-status-of-myocardial-perfusion
#13
Dong-Aolei An, Bing-Hua Chen, Rui-Wu, Ruo-Yang Shi, Jun Bu, Heng Ge, Jiani Hu, Jian-Rong Xu, Lian-Ming Wu
BACKGROUND: Acute myocardial infarction (AMI) is a major cause of morbidity and mortality worldwide and places a significant financial burden on our society. PURPOSE: To determine the feasibility of cardiac intravoxel incoherent motion (IVIM) in the consecutive evaluation of myocardial perfusion in myocardial infarction patients postpercutaneous coronary intervention (PCI) and to investigate the dynamic biological phenomena in myocardial perfusion after AMI. STUDY TYPE: Prospective observational study...
May 7, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29731119/relation-of-left-atrial-appendage-remodeling-by-magnetic-resonance-imaging-and-outcome-of-ablation-for-atrial-fibrillation
#14
Promporn Suksaranjit, Nassir F Marrouche, Frederick T Han, Alan Morris, Gagandeep Kaur, Tyson Oswald, Brent D Wilson
The left atrial appendage (LAA) is a nonpulmonary vein trigger site in atrial fibrillation (AF). The association of LAA structural remodeling (SRM) identified by late gadolinium enhancement magnetic resonance imaging (LGE-MRI) and AF ablation outcome has never been described. This study sought to investigate the clinical significance of LAA-SRM in AF patients who undergo ablation therapy. Consecutive patients with AF who underwent catheter ablation therapy within 14 days following MRI scan were included in this study...
March 29, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29728953/electrocardiography-based-prediction-of-hypertrophy-pattern-and-fibrosis-amount-in-hypertrophic-cardiomyopathy-comparative-study-with-cardiac-magnetic-resonance-imaging
#15
Chul Hwan Park, Hyemoon Chung, Yoonjung Kim, Jong-Youn Kim, Pil-Ki Min, Kyung-A Lee, Young Won Yoon, Tae Hoon Kim, Byoung Kwon Lee, Bum-Kee Hong, Se-Joong Rim, Hyuck Moon Kwon, Eui-Young Choi
Although, cardiac magnetic resonance imaging (CMR) is a gold standard for risk stratification of hypertrophic cardiomyopathy (HCM), is limited in some situations. We sought to evaluate the predictive power of quantitative electrocardiography in assessing hypertrophy pattern and fibrosis in HCM. Eighty-eight patients with HCM were studied. Voltage of R-S-T waves, number of fragmented QRS (fQRS) complexes, and T wave morphology were measured by 12-lead electrocardiography. Sixteen segmental thickness, late gadolinium enhancement (LGE), native T1, extracellular volume fraction (ECV), and T2, left ventricular (LV) mass and %LGE were measured by CMR...
May 4, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29728952/myocardial-perfusion-reserve-and-global-longitudinal-strain-as-potential-markers-of-coronary-allograft-vasculopathy-in-late-stage-orthotopic-heart-transplantation
#16
Akhil Narang, John E Blair, Mita B Patel, Victor Mor-Avi, Savitri E Fedson, Nir Uriel, Roberto M Lang, Amit R Patel
Coronary allograft vasculopathy (CAV) is a major cause of mortality in late-stage orthotopic heart transplantation (OHT) patients. Recent evidence has shown that myocardial perfusion reserve (MPR) derived from vasodilator cardiovascular magnetic resonance imaging (vCMR) and global longitudinal strain (GLS) from transthoracic echocardiography (TTE) are useful to detect CAV. However, previous studies have not comprehensively addressed whether these parameters are confounded by allograft rejection, myocardial scar/fibrosis, or allograft dysfunction...
May 4, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29728817/lge-cmr-derived-texture-features-reflect-poor-prognosis-in-hypertrophic-cardiomyopathy-patients-with-systolic-dysfunction-preliminary-results
#17
Sainan Cheng, Mengjie Fang, Chen Cui, Xiuyu Chen, Gang Yin, Sanjay K Prasad, Di Dong, Jie Tian, Shihua Zhao
OBJECTIVES: To evaluate the prognostic value of texture features based on late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) images in hypertrophic cardiomyopathy (HCM) patients with systolic dysfunction. METHODS: 67 HCM patients with systolic dysfunction (41 male and 26 female, mean age ± standard deviation, 46.20 years ± 13.38) were enrolled. All patients underwent 1.5 T CMR cine and LGE imaging. Texture features were extracted from LGE images...
May 4, 2018: European Radiology
https://www.readbyqxmd.com/read/29725307/comparing-reentrant-drivers-predicted-by-image-based-computational-modeling-and-mapped-by-electrocardiographic-imaging-in-persistent-atrial-fibrillation
#18
Patrick M Boyle, Joe B Hakim, Sohail Zahid, William H Franceschi, Michael J Murphy, Edward J Vigmond, Rémi Dubois, Michel Haïssaguerre, Mélèze Hocini, Pierre Jaïs, Natalia A Trayanova, Hubert Cochet
Electrocardiographic mapping (ECGI) detects reentrant drivers (RDs) that perpetuate arrhythmia in persistent AF (PsAF). Patient-specific computational models derived from late gadolinium-enhanced magnetic resonance imaging (LGE-MRI) identify all latent sites in the fibrotic substrate that could potentially sustain RDs, not just those manifested during mapped AF. The objective of this study was to compare RDs from simulations and ECGI (RDsim /RDECGI ) and analyze implications for ablation. We considered 12 PsAF patients who underwent RDECGI ablation...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29722466/post-procedural-lge-cmr-comparison-of-laser-and-radiofrequency-ablation-lesions-after-pulmonary-vein-isolation
#19
Rosa M Figueras I Ventura, Andrei D Mǎrgulescu, Eva M Benito, Francisco Alarcón, Norihiro Enomoto, Susanna Prat-Gonzalez, Rosario J Perea, Roger Borràs, Fredy Chipa, Elena Arbelo, Jose M Tolosana, Josep Brugada, Antonio Berruezo, Lluis Mont
INTRODUCTION: The purpose of this study was to compare the anatomical characteristics of scar formation achieved by visual guided laser balloon (Laser) and radiofrequency (RF) pulmonary vein isolation (PVI), using late-gadolinium-enhanced cardiac magnetic resonance imaging (LGE-CMR). METHODS AND RESULTS: We included 17 patients with paroxysmal or early persistent drug resistant AF who underwent Laser ablation; 2 were excluded due to procedure-related complications...
May 3, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29720202/optimization-of-late-gadolinium-enhancement-cardiovascular-magnetic-resonance-imaging-of-post-ablation-atrial-scar-a-cross-over-study
#20
Henry Chubb, Shadman Aziz, Rashed Karim, Christian Sohns, Orod Razeghi, Steven E Williams, John Whitaker, James Harrison, Amedeo Chiribiri, Tobias Schaeffter, Matthew Wright, Mark O'Neill, Reza Razavi
BACKGROUND: Cardiovascular magnetic resonance (CMR) imaging may be used to visualize post-ablation atrial scar (PAAS), and three-dimensional late gadolinium enhancement (3D LGE) is the most widely employed technique for imaging of chronic scar. Detection of PAAS provides a unique non-invasive insight into the effects of the ablation and may help guide further ablation procedures. However, there is evidence that PAAS is often not detected by CMR, implying a significant sensitivity problem, and imaging parameters vary between leading centres...
May 3, 2018: Journal of Cardiovascular Magnetic Resonance
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