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https://www.readbyqxmd.com/read/28933028/improving-fmri-in-signal-drop-out-regions-at-7%C3%A2-t-by-using-tailored-radio-frequency-pulses-application-to-the-ventral-occipito-temporal-cortex
#1
Catarina Rua, Stephen J Wastling, Mauro Costagli, Mark R Symms, Laura Biagi, Mirco Cosottini, Alberto Del Guerra, Michela Tosetti, Gareth J Barker
OBJECTIVE: Signal drop-off occurs in echo-planar imaging in inferior brain areas due to field gradients from susceptibility differences between air and tissue. Tailored-RF pulses based on a hyperbolic secant (HS) have been shown to partially recover signal at 3 T, but have not been tested at higher fields. MATERIALS AND METHODS: The aim of this study was to compare the performance of an optimized tailored-RF gradient-echo echo-planar imaging (TRF GRE-EPI) sequence with standard GRE-EPI at 7 T, in a passive viewing of faces or objects fMRI paradigm in healthy subjects...
September 20, 2017: Magma
https://www.readbyqxmd.com/read/28919104/elevated-urinary-monocyte-chemoattractant-protein-1-levels-in-children-with-henoch-schonlein-purpura-nephritis
#2
Jiapei Wang, Qianqian Ying, Shiling Zhong, Yuanling Chen, Yazhen Di, Xiahua Dai, Jika Zheng, Mengjiao Shen
BACKGROUND: Chemokine monocyte chemoattractant protein-1 (MCP-1) has been proved as a potential urinary biomarker in nephropathies. The aim of this study was to investigate the urinary monocyte chemoattractant protein-1 (MCP-1) levels and clinical significance in Henoch-Schonlein purpura (HSP) children with and without nephritis and determine the association of MCP-1 with proteinuria. METHODS: A total of 261 HSP children-with or without nephritis-and 84 healthy control children were enrolled in this study...
August 26, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28880217/the-ameliorative-effects-of-a-tocotrienol-rich-fraction-on-the-age-rage-axis-and-hypertension-in-high-fat-diet-fed-rats-with-metabolic-syndrome
#3
Hong Sheng Cheng, So Ha Ton, Joash Ban Lee Tan, Khalid Abdul Kadir
The clinical value of tocotrienols is increasingly appreciated because of the unique therapeutic effects that are not shared by tocopherols. However, their effect on metabolic syndrome is not well-established. This study aimed to investigate the effects of a tocotrienol-rich fraction (TRF) from palm oil in high-fat-diet-treated rats. Male, post-weaning Sprague Dawley rats were provided high-fat (60% kcal) diet for eight weeks followed by a TRF (60 mg/kg) treatment for another four weeks. Physical, metabolic, and histological changes were compared to those on control and high-fat diets respectively...
September 7, 2017: Nutrients
https://www.readbyqxmd.com/read/28861457/data-and-material-of-the-safe-range-inventory-an-assistance-tool-helping-to-improve-the-charging-infrastructure-for-electric-vehicles
#4
Claus-Christian Carbon, Fabian Gebauer
The Safe-Range-Inventory (SRI) was constructed in order to help public authorities to improve the charging infrastructures for electric vehicles [1; 10.1016/j.trf.2017.04.011]. Specifically, the impact of fast (vs slow) charging stations on people's range anxiety was examined. Ninety-seven electric vehicle users from Germany (81 male; Mage=46.3 years, SD=12.1) were recruited to participate in the experimental design. Statistical analyses were conducted using ANOVA for repeated measures to test for interaction effects of available charging stations and remaining range with the dependent variable range anxiety...
October 2017: Data in Brief
https://www.readbyqxmd.com/read/28855106/sample-processing-approach-for-detection-of-ricin-in-surface-samples
#5
Staci Kane, Sanjiv Shah, Anne Marie Erler, Teneile Alfaro
With several ricin contamination incidents reported over the past decade, rapid and accurate methods are needed for environmental sample analysis, especially after decontamination. A sample processing method was developed for common surface sampling devices to improve the limit of detection and avoid false negative/positive results for ricin analysis. Potential assay interferents from the sample matrix (bleach residue, sample material, wetting buffer), including reference dust, were tested using a Time-Resolved Fluorescence (TRF) immunoassay...
August 27, 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/28820218/photophysical-characterization-and-time-resolved-spectroscopy-of-a-anthradithiophene-dimer-exploring-the-role-of-conformation-in-singlet-fission
#6
Jacob C Dean, Ruomeng Zhang, Rawad K Hallani, Ryan D Pensack, Samuel N Sanders, Daniel G Oblinsky, Sean R Parkin, Luis M Campos, John E Anthony, Gregory D Scholes
Quantitative singlet fission has been observed for a variety of acene derivatives such as tetracene and pentacene, and efforts to extend the library of singlet fission compounds is of current interest. Preliminary calculations suggest anthradithiophenes exhibit significant exothermicity between the first optically-allowed singlet state, S1, and 2 × T1 with an energy difference of >5000 cm(-1). Given the fulfillment of this ingredient for singlet fission, here we investigate the singlet fission capability of a difluorinated anthradithiophene dimer (2ADT) covalently linked by a (dimethylsilyl)ethane bridge and derivatized by triisobutylsilylethynyl (TIBS) groups...
August 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28804275/metabolomics-based-markers-predict-type-2-diabetes-in-a-14-year-follow-up-study
#7
Jun Liu, Sabina Semiz, Sven J van der Lee, Ashley van der Spek, Aswin Verhoeven, Jan B van Klinken, Eric Sijbrands, Amy C Harms, Thomas Hankemeier, Ko Willems van Dijk, Cornelia M van Duijn, Ayşe Demirkan
BACKGROUND: The growing field of metabolomics has opened up new opportunities for prediction of type 2 diabetes (T2D) going beyond the classical biochemistry assays. OBJECTIVES: We aimed to identify markers from different pathways which represent early metabolic changes and test their predictive performance for T2D, as compared to the performance of traditional risk factors (TRF). METHODS: We analyzed 2776 participants from the Erasmus Rucphen Family study from which 1571 disease free individuals were followed up to 14-years...
2017: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/28803863/epidermal-e-cadherin-dependent-%C3%AE-catenin-pathway-is-phytochemical-inducible-and-accelerates-anagen-hair-cycling
#8
Noha S Ahmed, Subhadip Ghatak, Mohamed S El Masry, Surya C Gnyawali, Sashwati Roy, Mohamed Amer, Helen Everts, Chandan K Sen, Savita Khanna
Unlike the epidermis, which regenerates continually, hair follicles anchored in the subcutis periodically regenerate by spontaneous repetitive cycles of growth (anagen), degeneration (catagen), and rest (telogen). The loss of hair follicles in response to injuries or pathologies such as alopecia endangers certain inherent functions of the skin. Thus, it is of interest to understand mechanisms underlying follicular regeneration in adults. In this work, a phytochemical rich in the natural vitamin E tocotrienol (TRF) served as a productive tool to unveil a novel epidermal pathway of hair follicular regeneration...
July 20, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28761840/comparative-analysis-of-serum-copper-iron-ceruloplasmin-and-transferrin-levels-in-mild-and-severe-psoriasis-vulgaris-in-iranian-patients
#9
Mohammad Shahidi-Dadras, Nastaran Namazi, Shima Younespour
BACKGROUND: There is a great body of evidence indicating that some inflammatory skin diseases, such as psoriasis, are mediated by oxidative stress. Trace metals have been shown to be involved in oxidative stress response. Altered trace metal homeostasis in psoriasis has been studied. However, limited number of studies has focused on the involvement of metal binding proteins in psoriasis. MATERIALS AND METHODS: In a case control-study, serum levels of Iron (Fe), Copper (Cu), Transferrin (Trf), and Ceruloplasmin (Cp) were measured in 40 psoriasis patients and matched healthy controls...
July 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28752174/transferrin-coated-magnetic-upconversion-nanoparticles-for-efficient-photodynamic-therapy-with-near-infrared-irradiation-and-luminescence-bioimaging
#10
Dan Wang, Lin Zhu, Yuan Pu, Jie-Xin Wang, Jian-Feng Chen, Liming Dai
In the present study, we devised a green-synthesis route to NaYF4:Gd(3+),Yb(3+),Er(3+) upconversion nanoparticles (UCNPs) by using eco-friendly paraffin liquid, instead of 1-octadecene, as a high boiling non-coordinating solvent. A multifunctional nanoplatform was then developed by coating UCNPs with biocompatible transferrin (TRF) for magnetically-assisted and near-infrared light induced photodynamic therapy and bioimaging. Protoporphyrin IX (PpIX), a clinically approved photodynamic therapy agent, was loaded into the shell layer of the TRF-coated UCNPs (UCNP@TRF nanoparticles), which can be efficiently taken up by cancer cells for photodynamic therapy...
July 28, 2017: Nanoscale
https://www.readbyqxmd.com/read/28748484/assessing-for-suicidal-behavior-in-youth-using-the-achenbach-system-of-empirically-based-assessment
#11
Anna R Van Meter, Guillermo Perez Algorta, Eric A Youngstrom, Yana Lechtman, Jen K Youngstrom, Norah C Feeny, Robert L Findling
This study investigated the clinical utility of the Achenbach System of Empirically Based Assessment (ASEBA) for identifying youth at risk for suicide. Specifically, we investigated how well the Total Problems scores and the sum of two suicide-related items (#18 "Deliberately harms self or attempts suicide" and #91 "Talks about killing self") were able to distinguish youth with a history of suicidal behavior. Youth (N = 1117) aged 5-18 were recruited for two studies of mental illness. History of suicidal behavior was assessed by semi-structured interviews (K-SADS) with youth and caregivers...
July 26, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28721355/simultaneously-estimating-the-task-related-and-stimulus-evoked-components-of-hemodynamic-imaging-measurements
#12
Max Charles Herman, Mariana M B Cardoso, Bruss Lima, Yevgeniy B Sirotin, Aniruddha Das
Task-related hemodynamic responses contribute prominently to functional magnetic resonance imaging (fMRI) recordings. They reflect behaviorally important brain states, such as arousal and attention, and can dominate stimulus-evoked responses, yet they remain poorly understood. To help characterize these responses, we present a method for parametrically estimating both stimulus-evoked and task-related components of hemodynamic responses from subjects engaged in temporally predictable tasks. The stimulus-evoked component is modeled by convolving a hemodynamic response function (HRF) kernel with spiking...
July 2017: Neurophotonics
https://www.readbyqxmd.com/read/28715381/modified-terminal-restriction-fragment-analysis-for-quantifying-telomere-length-using-in-gel-hybridization
#13
Frank J Jenkins, Charles M Kerr, Elise Fouquerel, Dana H Bovbjerg, Patricia L Opresko
There are several different techniques for measuring telomere length, each with their own advantages and disadvantages. The traditional approach, Telomere Restriction Fragment (TRF) analysis, utilizes a DNA hybridization technique whereby genomic DNA samples are digested with restriction enzymes, leaving behind telomere DNA repeats and some sub-telomeric DNA. These are separated by agarose gel electrophoresis, transferred to a filter membrane and hybridized to oligonucleotide probes tagged with either chemiluminescence or radioactivity to visualize telomere restriction fragments...
July 10, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28708049/identification-of-two-novel-functional-trna-derived-fragments-induced-in-response-to-respiratory-syncytial-virus-infection
#14
Jiehua Zhou, Shenxuan Liu, Yu Chen, Yu Fu, Alexander J Silver, Mark S Hill, Inhan Lee, Yong Sun Lee, Xiaoyong Bao
Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection (LRTI) in children from infancy up to early childhood. Recently, we demonstrated that RSV infection alters cellular small non-coding RNA (sncRNA) expression, most notably the tRNA-derived RNA fragments (tRFs). However, the functions of the tRFs in virus-host interaction are largely unknown. Herein, we examined the role of three RSV-induced tRFs derived from the 5-end of mature tRNAs decoding GlyCCC, LysCTT and CysGCA (named tRF5-GlyCCC, tRF5-LysCTT and tRF5-CysGCA, respectively) in controlling RSV replication...
July 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28673689/higher-adherence-to-the-vegetable-rich-dietary-pattern-is-related-to%C3%A2-longer-telomere-length-in-women
#15
Yunhui Gong, Guo Tian, Hongmei Xue, Xiao Zhang, Yong Zhao, Guo Cheng
BACKGROUND & AIMS: Increasing evidence suggests a role of nutrition in aging process measured by telomere length (TL). However, data from Chinese are scarce. Moreover, the potential mechanism underlying diet and aging is not clear. Although inflammation has been hypothesized as one of the main factors, direct evidence is lacking. We examined whether dietary patterns were associated with TL in Chinese adults, with particular attention paid to body fat (excessive accumulation of body fat is a state of high-systematic oxidative stress and inflammation) and C-reactive protein (CRP, a marker of inflammation)...
May 11, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28666125/ltr-retrotransposon-control-by-trna-derived-small-rnas
#16
Andrea J Schorn, Michael J Gutbrod, Chantal LeBlanc, Rob Martienssen
Transposon reactivation is an inherent danger in cells that lose epigenetic silencing during developmental reprogramming. In the mouse, long terminal repeat (LTR)-retrotransposons, or endogenous retroviruses (ERV), account for most novel insertions and are expressed in the absence of histone H3 lysine 9 trimethylation in preimplantation stem cells. We found abundant 18 nt tRNA-derived small RNA (tRF) in these cells and ubiquitously expressed 22 nt tRFs that include the 3' terminal CCA of mature tRNAs and target the tRNA primer binding site (PBS) essential for ERV reverse transcription...
June 29, 2017: Cell
https://www.readbyqxmd.com/read/28659816/cardioprotective-effects-of-sirt6-in-a-mouse-model-of-transverse-aortic-constriction-induced-heart-failure
#17
Yongming Li, Xianda Meng, Wenguang Wang, Fu Liu, Zhiru Hao, Yang Yang, Jinbo Zhao, Wensi Yin, Lijuan Xu, Ruiping Zhao, Jiang Hu
SIRT6, a member of the NAD (+)-dependent class III deacetylase sirtuin family, plays important roles in the maintenance of cardiovascular homeostasis. Telomere shortening is a risk factor for age-associated diseases, including heart disease. In the present study, we investigated the role of SIRT6 and telomerase in a mouse model of transverse aortic constriction (TAC)-induced heart failure. SIRT6, telomerase reverse transcriptase (TERT), and telomere repeat binding factor (TRF)-1 were significantly downregulated in TAC mice compared with their expression in sham-operated mice...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28658261/sequential-sampling-of-visual-objects-during-sustained-attention
#18
Jianrong Jia, Ling Liu, Fang Fang, Huan Luo
In a crowded visual scene, attention must be distributed efficiently and flexibly over time and space to accommodate different contexts. It is well established that selective attention enhances the corresponding neural responses, presumably implying that attention would persistently dwell on the task-relevant item. Meanwhile, recent studies, mostly in divided attentional contexts, suggest that attention does not remain stationary but samples objects alternately over time, suggesting a rhythmic view of attention...
June 2017: PLoS Biology
https://www.readbyqxmd.com/read/28654015/lmp1-and-dynamic-progressive-telomere-dysfunction-a-major-culprit-in-ebv-associated-hodgkin-s-lymphoma
#19
REVIEW
Hans Knecht, Sabine Mai
Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) is expressed in germinal-center-derived, mononuclear Hodgkin (H) and multinuclear, diagnostic Reed-Sternberg (RS) cells in classical EBV-positive Hodgkin's lymphoma (cHL). LMP1 expression in EBV-negative H-cell lines results in a significantly increased number of RS cells. In a conditional, germinal-center-derived B-cell in vitro system, LMP1 reversibly down-regulates the shelterin proteins, telomeric repeat binding factor (TRF)1, TRF2, and protection of telomeres (POT)1...
June 27, 2017: Viruses
https://www.readbyqxmd.com/read/28608481/discovery-and-function-of-transfer-rna-derived-fragments-and-their-role-in-disease
#20
REVIEW
Ana Raquel Soares, Manuel Santos
Until recently, transfer RNAs (tRNAs) were thought to function in protein translation only. However, recent findings demonstrate that both pre- and mature tRNAs can undergo endonucleolytic cleavage by different ribonucleases originating different types of small non-coding RNAs, known as tRNA-derived fragments (tRFs). tRFs are classified according to their origin and are implicated in various cellular processes, namely apoptosis, protein synthesis control, and RNA interference. Although their functions are still poorly understood, their mechanisms of action vary according to the tRF sub-type...
September 2017: Wiley Interdisciplinary Reviews. RNA
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