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https://www.readbyqxmd.com/read/27906473/tensile-comparison-of-polydioxanone-polyglyconate-and-barbed-glycolide-trimethylene-carbonate-suture-in-canine-cadaveric-tensor-fascia-lata
#1
Naomi Shimizu, John Tarlton, Ed Friend, Ivan Doran, Kevin Parsons
OBJECTIVE: To compare the mode of failure, load at yield, ultimate load to failure and stiffness of non-barbed polydioxanone, non-barbed polyglyconate and barbed glycolide-trimethylene carbonate (GTC) suture in canine cadaveric fascia. STUDY DESIGN: Ex vivo biomechanical study. SAMPLE POPULATION: 18 fascia lata specimens from 9 canine cadavers. METHODS: 6 fascia lata specimens were sutured with polydioxanone, 6 with polyglyconate, and 6 with barbed GTC suture...
December 1, 2016: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/27906050/the-sh3-and-cysteine-rich-domain-3-stac3-gene-is-important-to-growth-fiber-composition-and-calcium-release-from-the-sarcoplasmic-reticulum-in-postnatal-skeletal-muscle
#2
Xiaofei Cong, Jonathan Doering, Davi A G Mazala, Eva R Chin, Robert W Grange, Honglin Jiang
BACKGROUND: The SH3 and cysteine-rich domain 3 (Stac3) gene is specifically expressed in the skeletal muscle. Stac3 knockout mice die perinatally. In this study, we determined the potential role of Stac3 in postnatal skeletal muscle growth, fiber composition, and contraction by generating conditional Stac3 knockout mice. METHODS: We disrupted the Stac3 gene in 4-week-old male mice using the Flp-FRT and tamoxifen-inducible Cre-loxP systems. RESULTS: RT-qPCR and western blotting analyses of the limb muscles of target mice indicated that nearly all Stac3 mRNA and more than 70 % of STAC3 protein were deleted 4 weeks after tamoxifen injection...
April 11, 2016: Skeletal Muscle
https://www.readbyqxmd.com/read/27904965/chitosan-hydrogel-microspheres-an-effective-covalent-matrix-for-crosslinking-of-soluble-dextranase-to-increase-stability-and-recycling-efficiency
#3
Faiza Shahid, Afsheen Aman, Muhammad Asif Nawaz, Asad Karim, Shah Ali Ul Qader
Dextranase is a unique biocatalyst that has high specificity and stereo-selectivity towards a complex biopolymer known as dextran. Dextranase has wide industrial application, but most of the time harsh environmental conditions adversely affect the functionality and stability of the enzyme. To overcome this issue, a covalent cross-linking immobilization method was adapted in the current study utilizing a nontoxic and biocompatible matrix known as chitosan. Chitosan hydrogel microspheres were synthesized using chitosan which exhibited noteworthy physical and mechanical strength...
November 30, 2016: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/27904800/cervical-contribution-to-functional-shoulder-impingement-two-case-reports
#4
Steven Pheasant
BACKGROUND: Subacromial impingement is a common condition among overhead athletes. The cause of subacromial impingement can be multifactorial and often involves impaired rotator cuff function. CASE DESCRIPTION: The following cases outline the presentation, examination and intervention of two overhead athletes, a high school football quarterback and a collegiate swimmer, each presenting with signs and symptoms of subacromial impingement. The unique feature in each case was the manifestation of the cervical spine as the apparent source of rotator cuff weakness, which contributed to functional subacromial impingement although other overt signs of cervical or associated nerve root involvement were absent...
December 2016: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/27904519/mind-conduct-disorders-in-children-with-poor-oral-hygiene-habits-and-attention-deficit-hyperactivity-disorder-in-children-with-excessive-tooth-decay
#5
Onur Burak Dursun, Fatih Şengül, İbrahim Selçuk Esin, Tevfik Demirci, Nermin Yücel, Mehmet Melih Ömezli
INTRODUCTION: Dental caries and poor oral hygiene are among the major childhood public health problems. Although dental research frequently refers to the link between these conditions and behavioural issues, little attention has been paid to understanding the reason for oral health problems from a psychiatric point of view. The aim of this study was to examine the relationship between poor oral health and hygiene and parental attitudes towards child rearing, parents' and children's oral hygiene behaviours, and childhood psychiatric disorders...
December 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27904030/formulation-optimization-and-in-vitro-characterization-of-orally-disintegrating-films-using-a-factorial-design-and-mathematical-modeling-for-drug-release
#6
Yeongbin Lee, Prakash Thapa, Seong Hoon Jeong, Mi Hee Woo, Du Hyung Choi
Even though experimental designs are becoming popular especially for conventional dosage forms, limited studies have been performed to optimize formulations of orally disintegrating films (ODFs). This study aimed to evaluate sildenafil citrate-loaded ODFs for a controlled release with hydroxypropyl methylcellulose as a film-forming polymer. A factorial design was utilized for optimization with three control factors: ethanol ratio, plasticizer ratio, and the type of plasticizer. Tensile strength, disintegration time, water contact angle, and thickness were chosen as responses...
November 30, 2016: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27903730/network-patterns-associated-with-navigation-behaviors-are-altered-in-aged-nonhuman-primates
#7
James R Engle, Christopher J Machado, Michele R Permenter, Julie A Vogt, Andrew P Maurer, Alicia M Bulleri, Carol A Barnes
: The ability to navigate through space involves complex interactions between multiple brain systems. Although it is clear that spatial navigation is impaired during aging, the networks responsible for these altered behaviors are not well understood. Here, we used a within-subject design and [(18)F]FDG-microPET to capture whole-brain activation patterns in four distinct spatial behaviors from young and aged rhesus macaques: constrained space (CAGE), head-restrained passive locomotion (CHAIR), constrained locomotion in space (TREADMILL), and unconstrained locomotion (WALK)...
November 30, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27902895/pathogeny-of-fatigued-walking-condition-in-pekin-ducks
#8
M J Da Costa, E O Oviedo-Rondón, M Wineland, D Jeffrey
Fatigued walking condition (FWC) in ducks is an important welfare and processing issue during the loading/unloading to the processing plant that can be related to heart and bone development. An experiment was conducted to evaluate the effects of incubation conditions on duck embryo bone and heart development and their subsequent effects on ducks showing FWC at market age. Four groups of 2500 Pekin duck eggs were subjected to combinations of two incubation temperature profiles (elevated [E] and normal [N]) and two eggshell conductance profiles (G) (reduced [GR] and normal [GN])...
December 2016: Avian Diseases
https://www.readbyqxmd.com/read/27902841/dynamical-effects-of-calcium-sensitive-potassium-currents-on-voltage-and-calcium-alternans
#9
Matthew Kennedy, Donald M Bers, Nipavan Chiamvimonvat, Daisuke Sato
Cardiac alternans is a precursor to life-threatening arrhythmias. Alternans can be caused by instability of the membrane voltage (Vm ), instability of the intracellular Ca (Cai ) cycling, or both. Vm dynamics and Cai dynamics are coupled via Ca-sensitive currents. In cardiac myocytes, there are several Ca-sensitive potassium (K) currents such as the slowly activating delayed rectifier current (IKs ) and the small conductance Ca-activated potassium (SK) current (ISK ). However, the role of these currents in the development of arrhythmias is not well understood...
November 30, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27902168/biomechanical-comparison-of-pullout-strengths-of-five-cortical-screw-types-an-innovative-measurement-method
#10
Ahmet Karakaşlı, Nihat Acar, Mehmet Hilal Özcanhan, Fatih Ertem
OBJECTIVES: This study aims to assess five different cortical screw types using artificial femurs, under equated testing conditions. MATERIALS AND METHODS: We investigated the maximum force needed to cause deformation at screw-bone interface using fourth generation composite femurs by conducting separate pullout tests for each screw type. We normalized obtained results with traditional methods and cross-comparison. To conduct pullout tests dependent on screw dimensions, we eliminated the effect of bicortical bone thickness by equalizing the conditions of screw insertion...
December 2016: Eklem Hastalıkları Ve Cerrahisi, Joint Diseases & related Surgery
https://www.readbyqxmd.com/read/27901359/buprenorphine-transdermal-system-utilization
#11
Laura Wallace, Aditi Kadakia
OBJECTIVES: To evaluate utilization patterns in patients initiating buprenorphine transdermal system (BTDS), CIII, and estimate the proportion decreasing their total opioid dose over time. METHODS: This retrospective cohort study used data from the Truven Health Analytics MarketScan® Commercial Claims and Encounters Database from January 1, 2011 through December 31, 2015. Eligible individuals were adults aged 18-64 years newly dispensed BTDS (index prescription) who had at least six months of insurance coverage prior to (baseline period) and following (study period) the index prescription...
November 30, 2016: Postgraduate Medicine
https://www.readbyqxmd.com/read/27900312/posterior-tibial-tendon-displacement-behind-the-tibia-and-its-interposition-in-an-irreducible-isolated-ankle-dislocation-a-case-report-and-literature-review
#12
Alessandro Ortolani, Roberto Bevoni, Alessandro Russo, Maurilio Marcacci, Mauro Girolami
Isolated posteromedial ankle dislocation is a rare condition thanks to the highly congruent anatomical configuration of the ankle mortise, in which the medial and lateral malleoli greatly reduce the rotational movement of the talus, and the strength of the ligaments higher than the malleoli affords protection against fractures. However, other factors, like medial malleolus hypoplasia, laxity of the ligaments, peroneal muscle weakness and previous ankle sprains, could predispose to pure dislocation. In the absence of such factors, only a complex high-energy trauma, with a rotational component, can lead to this event...
July 2016: Joints
https://www.readbyqxmd.com/read/27899894/moderate-load-eccentric-exercise-a-distinct-novel-training-modality
#13
REVIEW
Hans Hoppeler
Over the last 20 years a number of studies have been published using progressive eccentric exercise protocols on motorized ergometers or similar devices that allow for controlled application of eccentric loads. Exercise protocols ramp eccentric loads over an initial 3 weeks period in order to prevent muscle damage and delayed onset muscle soreness. Final training loads reach 400-500 W in rehabilitative settings and over 1200 W in elite athletes. Training is typically carried out three times per week for durations of 20-30 min...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27898384/passivity-and-output-synchronization-of-complex-dynamical-networks-with-fixed-and-adaptive-coupling-strength
#14
Jin-Liang Wang, Huai-Ning Wu, Tingwen Huang, Shun-Yan Ren, Jigang Wu
This paper considers a complex dynamical network model, in which the input and output vectors have different dimensions. We, respectively, investigate the passivity and the relationship between output strict passivity and output synchronization of the complex dynamical network with fixed and adaptive coupling strength. First, two new passivity definitions are proposed, which generalize some existing concepts of passivity. By constructing appropriate Lyapunov functional, some sufficient conditions ensuring the passivity, input strict passivity and output strict passivity are derived for the complex dynamical network with fixed coupling strength...
November 24, 2016: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/27897456/estimating-between-person-and-within-person-subscore-reliability-with-profile-analysis
#15
Okan Bulut, Mark L Davison, Michael C Rodriguez
Subscores are of increasing interest in educational and psychological testing due to their diagnostic function for evaluating examinees' strengths and weaknesses within particular domains of knowledge. Previous studies about the utility of subscores have mostly focused on the overall reliability of individual subscores and ignored the fact that subscores should be distinct and have added value over the total score. This study introduces a profile reliability approach that partitions the overall subscore reliability into within-person and between-person subscore reliability...
November 29, 2016: Multivariate Behavioral Research
https://www.readbyqxmd.com/read/27897431/prevalence-and-incidence-of-sarcopenia-in-the-very-old-findings-from-the-newcastle-85-study
#16
Richard Matthew Dodds, Antoneta Granic, Karen Davies, Thomas B L Kirkwood, Carol Jagger, Avan Aihie Sayer
INTRODUCTION: Recognition that an older person has sarcopenia is important because this condition is linked to a range of adverse outcomes. Sarcopenia becomes increasingly common with age, and yet there are few data concerning its descriptive epidemiology in the very old (aged 85 years and above). Our aims were to describe risk factors for sarcopenia and estimate its prevalence and incidence in a British sample of the very old. METHODS: We used data from two waves (2006/07 and 2009/10) of the Newcastle 85+ Study, a cohort born in 1921 and registered with a Newcastle/North Tyneside general practice...
November 16, 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27897395/the-human-skeletal-muscle-proteome-project-a-reappraisal-of-the-current-literature
#17
REVIEW
Marta Gonzalez-Freire, Richard D Semba, Ceereena Ubaida-Mohien, Elisa Fabbri, Paul Scalzo, Kurt Højlund, Craig Dufresne, Alexey Lyashkov, Luigi Ferrucci
Skeletal muscle is a large organ that accounts for up to half the total mass of the human body. A progressive decline in muscle mass and strength occurs with ageing and in some individuals configures the syndrome of 'sarcopenia', a condition that impairs mobility, challenges autonomy, and is a risk factor for mortality. The mechanisms leading to sarcopenia as well as myopathies are still little understood. The Human Skeletal Muscle Proteome Project was initiated with the aim to characterize muscle proteins and how they change with ageing and disease...
August 3, 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27897254/high-level-expression-of-improved-thermo-stable-alkaline-xylanase-variant-in-pichia-pastoris-through-codon-optimization-multiple-gene-insertion-and-high-density-fermentation
#18
Yihong Lu, Cheng Fang, Qinhong Wang, Yuling Zhou, Guimin Zhang, Yanhe Ma
In paper industry, xylanases are used to increase the pulp properties in bleaching process as its eco-friendly nature. The xylanases activity is hindered by high temperature and alkaline conditions with high enzyme production cost in the paper industry. Here, XynHB, an alkaline stable xylanase from Bacillus pumilus HBP8 was mutated at N188A to XynHBN188A. Expressed mutant in E. coli showed 1.5-fold higher xylanase activity than XynHB at 60 °C. The mutant expressed in Pichia pastoris was glycosylated, remained stable for 30 min at 60 °C...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27896986/network-map-of-adverse-health-effects-among-victims-of-intimate-partner-violence
#19
Kathleen Whiting, Larry Y Liu, Mehmet Koyutürk, Günnur Karakurt
Intimate partner violence (IPV) is a serious problem with devastating health consequences. Screening procedures may overlook relationships between IPV and negative health effects. To identify IPV-associated women's health issues, we mined national, aggregated de-identified electronic health record data and compared female health issues of domestic abuse (DA) versus non-DA records, identifying terms significantly more frequent for the DA group. After coding these terms into 28 broad categories, we developed a network map to determine strength of relationships between categories in the context of DA, finding that acute conditions are strongly connected to cardiovascular, gastrointestinal, gynecological, and neurological conditions among victims...
2016: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27896949/sarcopenia-predicts-readmission-and-mortality-in-elderly-patients-in-acute-care-wards-a-prospective-study
#20
Ming Yang, Xiaoyi Hu, Haozhong Wang, Lei Zhang, Qiukui Hao, Birong Dong
OBJECTIVES: The aim of this study is to assess the prevalence of sarcopenia and investigate the associations between sarcopenia and long-term mortality and readmission in a population of elderly inpatients in acute care wards. METHODS: We conducted a prospective observational study in the acute care wards of a teaching hospital in western China. The muscle mass was estimated according to a previously validated anthropometric equation. Handgrip strength was measured with a handheld dynamometer, and physical performance was measured via a 4 m walking test...
November 28, 2016: Journal of Cachexia, Sarcopenia and Muscle
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