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https://www.readbyqxmd.com/read/28806330/nanoci-nanotechnology-based-cochlear-implant-with-gapless-interface-to-auditory-neurons
#1
Pascal Senn, Marta Roccio, Stefan Hahnewald, Claudia Frick, Monika Kwiatkowska, Masaaki Ishikawa, Peter Bako, Hao Li, Fredrik Edin, Wei Liu, Helge Rask-Andersen, Ilmari Pyykkö, Jing Zou, Marika Mannerström, Herbert Keppner, Alexandra Homsy, Edith Laux, Miguel Llera, Jean-Paul Lellouche, Stella Ostrovsky, Ehud Banin, Aharon Gedanken, Nina Perkas, Ute Wank, Karl-Heinz Wiesmüller, Pavel Mistrík, Heval Benav, Carolyn Garnham, Claude Jolly, Filippo Gander, Peter Ulrich, Marcus Müller, Hubert Löwenheim
: Cochlear implants (CI) restore functional hearing in the majority of deaf patients. Despite the tremendous success of these devices, some limitations remain. The bottleneck for optimal electrical stimulation with CI is caused by the anatomical gap between the electrode array and the auditory neurons in the inner ear. As a consequence, current devices are limited through 1) low frequency resolution, hence sub-optimal sound quality and 2), large stimulation currents, hence high energy consumption (responsible for significant battery costs and for impeding the development of fully implantable systems)...
September 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28805009/using-endoscopy-to-locate-the-round-window-membrane-during-cochlear-implantation-our-experience-with-25-patients
#2
Y H Chen, T C Liu, T H Yang, K N Lin, C C Wu, C J Hsu
Locating the round window membrane during cochlear implantation surgery is crucial to insert the electrode array correctly and to minimize intracochlear damage. However, it can be difficult to access the round window membrane in certain patients, especially in paediatric patients or patients with inner ear malformations. Recently, it has been demonstrated that endoscopy enables excellent visualization and exploration of the round window niche in ear surgery. This article is protected by copyright. All rights reserved...
August 14, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28803051/variations-in-the-labyrinthine-segment-of-facial-nerve-canal-revealed-by-high-resolution-computed-tomography
#3
Aiyan Jin, Peng Xu, Fengqin Qu
OBJECTIVE: To study variations in the labyrinthine segment of fallopian canal and the associated middle and inner ear malformations. METHOD: The high-resolution computed tomography (HRCT) images of the temporal bone in 24 patients with congenital variations in the labyrinthine segment of fallopian canal were analyzed retrospectively. The length of labyrinthine segment of the facial nerve and angle of the first genu of 10 normal subjects were also measured. Based on the original axial images, multi-planar reformation (MPR) and curved-planar reformation (CPR) images of bilateral ossicular chains, inner ear structure and fallopian canal were reconstructed...
August 9, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28802357/evaluation-of-ototoxicity-of-intratympanic-administration-of-methotrexate-in-rats
#4
Sabri Baki Eren, Remzi Dogan, Alper Yenigun, Bayram Veyseller, Selahattin Tugrul, Orhan Ozturan, Mehmet Serif Aydin
OBJECTIVE: Methotrexate is a dihydrofolate reductase enzyme inhibitor with very high selectivity, and it is an antiproliferative folic acid antagonist used for the treatment of autoimmune diseases. In this study, our objective was to evaluate the effect of intratympanic Methotrexate application in the inner ear. METHODS: This study was planned as an animal study. This study performed in a tertiary referral center. 24 healthy female rats were used in our study. They were separated into three groups...
September 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28802353/hearing-loss-in-children-with-growth-hormone-deficiency
#5
John S Muus, Forest W Weir, Kathryn L Kreicher, Deborah A Bowlby, Christopher M Discolo, Ted A Meyer
OBJECTIVE: Although insulin-like growth factor 1 (IGF-1) has been shown to be important for inner-ear development in animal models, little is known about the otologic and audiologic findings of children with growth hormone deficiency (GHD). The goal of this study is to evaluate the prevalence, type, and severity of hearing impairment in children with GHD. METHODS: Audiologic, otologic, and demographic data were recorded for children with a diagnosis of GHD in the AudGen database...
September 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28796081/the-seasonal-variation-of-benign-paroxysmal-positional-vertigo
#6
Sheneen Meghji, Declan Murphy, Ian Nunney, John S Phillips
OBJECTIVE: Benign paroxysmal positional vertigo (BPPV) is characterized by recurrent episodes of positional vertigo due to dislodged otoconia debris within the semicircular canals. Many studies have proposed a correlation between Vitamin-D deficiency and recurrent BPPV. In the UK, serum Vitamin-D falls during the winter, reaching its lowest level in May and it is highest level in September. We hypothesize that if there is a relationship between BPPV and Vitamin-D levels, one would expect to see a seasonal variation in the incidence of BPPV among UK residents...
August 8, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28794912/sensorineural-hearing-loss-in-a-patient-affected-by-congenital-cytomegalovirus-infection-is-it-useful-to-identify-comorbid-pathologies
#7
P Fontana, D Melis, A D'Amico, G Cappuccio, G Auletta, P Vassallo, R Genesio, L Nitsch, W Buffolano
Sensorineural hearing loss (SNHL) is a common defect with a multifactorial etiology. Congenital cytomegalovirus infection (cCMV) is the most common infectious cause, and its early detection allows a prompt pharmacological treatment that can improve hearing prognosis. In a consistent percentage of profound SNHL, genetic causes and/or inner ear malformations are involved; their prompt diagnosis might change therapeutic options. This study reports a case of a 3- year-old female patient with symptomatic cCMV infection who also exhibits developmental delay, dysmorphic facial features, bilateral hearing loss, and cochlear incomplete partition, type 2, in 7q21...
September 2017: Journal of Pediatric Genetics
https://www.readbyqxmd.com/read/28794401/three-dimensional-reconstruction-of-root-cells-and-interdental-cells-in-the-rat-inner-ear-by-serial-section-scanning-electron-microscopy
#8
Ryusuke Shodo, Manabu Hayatsu, Daisuke Koga, Arata Horii, Tatsuo Ushiki
In the cochlea, a high K(+) environment in the endolymph is essential for the maintenance of normal hearing function, and the transport of K(+) ions through gap junctions of the cochlear epithelium is thought to play an important role in endolymphatic homeostasis. The aim of the present study was to demonstrate the three-dimensional (3D) ultrastructure of spiral ligament root cells and interdental cells, which are located at both ends of the gap junction system of the cochlea epithelium. Serial semi-thin sections of plastic-embedded rat cochlea were mounted on glass slides, stained with uranyl acetate and lead citrate, and observed by scanning electron microscopy (SEM) using the backscattered electron (BSE) mode...
2017: Biomedical Research
https://www.readbyqxmd.com/read/28793961/hearing-loss-in-enlarged-vestibular-aqueduct-and-incomplete-partition-type-ii
#9
Emily Ahadizadeh, Mustafa Ascha, Nauman Manzoor, Amit Gupta, Maroun Semaan, Cliff Megerian, Todd Otteson
PURPOSE: The purpose of this work is to identify the role of incomplete partition type II on hearing loss among patients with enlarged vestibular aqueduct (EVA). BACKGROUND: EVA is a common congenital inner ear malformation among children with hearing loss, where vestibular aqueduct morphology in this population has been shown to correlate to hearing loss. However, the impact of incomplete partition between cochlear turns on hearing loss has not been, despite meaningful implications for EVA pathophysiology...
June 23, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28791351/altered-gene-expression-profile-in-a-rat-model-of-gentamicin-induced-ototoxicity-and-nephrotoxicity-and-the-potential-role-of-upregulated-ifi44-expression
#10
Jun-Gen Hu, Yu Fu, Jian-Ju Xu, Xian-Ping Ding, Hui-Qi Xie, Jesse Li-Ling
As demonstrated by Alport syndrome, the co‑occurrence of auditory and urinary system malformations, and gentamicin-induced ototoxicity and nephrotoxicity, the ears and kidneys potentially share certain molecular pathways. In the present study, microarray chips were used to analyze the changes in the gene expression profile using a rat model of gentamicin‑induced ototoxicity and nephrotoxicity, using rat liver tissue as a control. A number of genes were identified to exhibit similar expression changes in the rat ears and kidney tissues, among which microtubule‑associated protein 44 (Ifi44), was selected for further analysis to validate its expression changes and confirm potential involvement in the inflammation process in the disease model...
August 2, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28790422/spiral-form-of-the-human-cochlea-results-from-spatial-constraints
#11
M Pietsch, L Aguirre Dávila, P Erfurt, E Avci, T Lenarz, A Kral
The human inner ear has an intricate spiral shape often compared to shells of mollusks, particularly to the nautilus shell. It has inspired many functional hearing theories. The reasons for this complex geometry remain unresolved. We digitized 138 human cochleae at microscopic resolution and observed an astonishing interindividual variability in the shape. A 3D analytical cochlear model was developed that fits the analyzed data with high precision. The cochlear geometry neither matched a proposed function, namely sound focusing similar to a whispering gallery, nor did it have the form of a nautilus...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28783589/infection-exposure-detection-and-causes-of-death-in-perinatal-mortalities-in-polish-dairy-herds
#12
Paulina Jawor, Dawid Król, John F Mee, Zenon Sołtysiak, Stanisław Dzimira, Magdalena Larska, Tadeusz Stefaniak
The objective of this study was to determine the prevalence and types of infections in perinatal mortality (PM) cases from Polish dairy farms and the relevance of the presence of infection to the cause of death. This prospective longitudinal study was carried out on 121 PM and 21 control calves with a gestation of ≥260 days. Six control calves were euthanized and examined using the same protocol as for PM calves. Material was collected over a 20-month period between November 2013 and June 2015. The PM and control calves were collected from 29 to 5 herds, respectively...
July 29, 2017: Theriogenology
https://www.readbyqxmd.com/read/28777514/our-experience-in-the-treatment-of-idiopathic-sensorineural-hearing-loss-isnhl-effect-of-combination-therapy-with-hbo%C3%A2-and-vasodilator-infusion-therapy
#13
Barbora Kratochvílovà, Oliver Profant, Jaromír Astl, Richard Holý
Idiopathic sensorineural hearing loss (ISNHL) is a hearing impairment that occurs suddenly with onset over a period of 24 to 72 hours, affecting at least three adjacent frequencies with hearing loss of 30 decibels or more, caused by damage to the inner ear or auditory nerve without clear reasons. The treatment of ISNHL is still a hot topic. In a retrospective study, we examined 88 patients with ISNHL (2008-2013). The objective of the study was to compare the effects of two different types of therapy: vasodilator infusion treatment combined with hyperbaric oxygen (HBO₂) therapy vs...
November 2016: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/28777373/the-mir-183-itga3-axis-is-a-key-regulator-of-prosensory-area-during-early-inner-ear-development
#14
Priscilla Van den Ackerveken, Anaïs Mounier, Aurelia Huyghe, Rosalie Sacheli, Pierre-Bernard Vanlerberghe, Marie-Laure Volvert, Laurence Delacroix, Laurent Nguyen, Brigitte Malgrange
MicroRNAs are important regulators of gene expression and are involved in cellular processes such as proliferation or differentiation, particularly during development of numerous organs including the inner ear. However, it remains unknown if miRNAs are required during the earliest stages of otocyst and cochlear duct development. Here, we report that a conditional loss of Dicer expression in the otocyst impairs the early development of the inner ear as a result of the accumulation of DNA damage that trigger p53-mediated apoptosis...
August 4, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28776202/neurotrophin-gene-therapy-in-deafened-ears-with-cochlear-implants-long-term-effects-on-nerve-survival-and-functional-measures
#15
Bryan E Pfingst, Deborah J Colesa, Donald L Swiderski, Aaron P Hughes, Stefan B Strahl, Moaz Sinan, Yehoash Raphael
Because cochlear implants function by stimulating the auditory nerve, it is assumed that the condition of the nerve plays an important role in the efficacy of the prosthesis. Thus, considerable research has been devoted to methods of preserving the nerve following deafness. Neurotrophins have been identified as a potential contributor to neural health, but most of the research to date has been done in young animals and for short periods (less than 3 to 6 months) after the onset of treatment. The first objective of the current experiment was to examine the effects of a neurotrophin gene therapy delivery method on spiral ganglion neuron (SGN) preservation and function in the long term (5 to 14 months) in mature guinea pigs with cochlear implants...
August 3, 2017: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/28763630/growth-of-hollow-cell-spheroids-in-microbead-templated-chambers
#16
Eddie Wang, Dong Wang, Andrew Geng, Richard Seo, Xiaohua Gong
Cells form hollow, spheroidal structures during the development of many tissues, including the ocular lens, inner ear, and many glands. Therefore, techniques for in vitro formation of hollow spheroids are valued for studying developmental and disease processes. Current in vitro methods require cells to self-organize into hollow morphologies; we explored an alternative strategy based on cell growth in predefined, spherical scaffolds. Our method uses sacrificial, gelatin microbeads to simultaneously template spherical chambers within a hydrogel and deliver cells into the chambers...
July 26, 2017: Biomaterials
https://www.readbyqxmd.com/read/28761208/sudden-bilateral-sensorineural-hearing-loss-following-postpartum-hemorrhage-a-case-report
#17
Sara Mirzaeian, Sedigheh Ayati, Asieh Maleki
The prevalence of bilateral sudden sensorineural hearing loss (SSNHL) is less than 5% and the etiology of most cases is unknown. Due to many structural and functional similarities between the kidney and inner ear, many conditions, diseases, and drugs have both renal and cochlear effects and toxicities. There are several reports of SSNHL in patients with CRF, uraemic patient, hemodialysis treatment, and ARF. Here, we report a rare manifestation of SSNHL following severe postpartum hemorrhage that has simultaneous renal failure and cochlear impairment...
July 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28760332/evidence-of-surgical-treatments-for-intractable-meniere-s-disease
#18
REVIEW
Tadashi Kitahara
Meniere's disease is an inner ear disease, characterized by recurrent rotatory vertigo, sensorineural hearing loss and tinnitus. There are some with frequent vertigo attacks, progressive hearing loss and persistent annoying tinnitus even through the continuous standard medical treatments. These cases are thought to account for 10%-20% of all cases of Meniere's disease. In this review article, we would like to demonstrate the evidences for surgical treatments according to the previous papers, and consider the next therapeutic strategies including surgical options according to the international guidelines...
July 28, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28756569/sudden-hearing-loss-an-effectivity-comparison-of-intratympanic-and-systemic-steroid-treatments
#19
Gülce Ermutlu, Nilda Süslü, Taner Yılmaz, Sarp Saraç
Corticosteroid treatment has been considered the most effective treatment modality for sudden sensorineural hearing loss so far. Application route of corticosteroids may vary. We have designed a prospective randomized case-controlled clinical trial to evaluate the effectivenesses of the different application routes of steroids in the treatment of SSHL. Thirty-five patients were distributed randomly to two groups which were treated with either 'oral' or 'intratympanic' corticosteroids. Intratympanic steroid administration was performed three times every other day transtympanically...
July 29, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28754998/oral-exposure-to-arsenic-causes-hearing-loss-in-young-people-aged-12-29-years-and-in-young-mice
#20
Xiang Li, Nobutaka Ohgami, Yasuhiro Omata, Ichiro Yajima, Machiko Iida, Reina Oshino, Shoko Ohnuma, Nazmul Ahsan, Anwarul Azim Akhand, Masashi Kato
There is no information on the association between oral exposure to arsenic (As) and hearing loss in humans or mice. In this combined epidemiological study and experimental study, the association of oral exposure to As with hearing loss in people aged 12-29 years and young mice was examined. Subjects in the exposure group (n = 48), who were drinking tube well water contaminated with As, showed significantly higher risks of hearing loss at 4 kHz [odds ratio (OR) = 7.60; 95% confidence interval (CI): 1...
July 28, 2017: Scientific Reports
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