keyword
MENU ▼
Read by QxMD icon Read
search

Hair cell

keyword
https://www.readbyqxmd.com/read/28945013/pro-regenerative-hydrogel-restores-scarless-skin-during-cutaneous-wound-healing
#1
Guoming Sun
The transformation of fibrotic healing process to regenerative one has great potential to fully restore wounded skin. The M2 macrophage phenotype promotes constructive tissue remodeling and instructs tissue repair in a regenerative manner. It is hypothesized that hydrogels that can establish robustness of endogenous cells to regulate M2 phenotype will promote constructive dermal remodeling. Toward this end, a series of dextran-based bioabsorbable hydrogels are developed and self-crosslinkable dextran-isocyanatoethyl methacrylate-ethylamine (DexIEME) is identified as the potential scaffold...
September 25, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28944964/wnt-%C3%AE-catenin-and-erk-pathway-activation-a-possible-mechanism-of-photobiomodulation-therapy-with-light-emitting-diodes-that-regulate-the-proliferation-of-human-outer-root-sheath-cells
#2
Jung E Kim, Young J Woo, Ki M Sohn, Kwan H Jeong, Hoon Kang
BACKGROUND: Outer root sheath cells (ORSCs) play important roles in maintaining hair follicle structure and provide support for the bulge area. The hair growth promoting effects of photobiomodulation therapy (PBMT) have been reported, but the mechanisms for this in human ORCs (hORSCs) have rarely been studied. OBJECTIVE: The aim of this study was to investigate the effect of various wavelengths of light-emitting diode (LED) irradiation on human ORSCs (hORSCs). METHODS: LED irradiation effects on hORSC proliferation and migration were examined with MTT assay, BrdU incorporation assay and migration assays...
September 25, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28944415/nectar-and-oleiferous-trichomes-as-floral-attractants-in-bulbophyllum-saltatorium-lindl-orchidaceae
#3
Małgorzata Stpiczyńska, Bartosz J Płachno, Kevin L Davies
Although many Orchidaceae have deceit flowers that produce no reward, the most common reward, when present, is nectar. Bulbophyllum, however, is unusual in that the labellar secretions of most species investigated to date lack sugars, and, therefore, cannot be considered true nectar. The African species Bulbophyllum saltatorium is an exception in that it produces not only nectar but also possesses specialized, capitate oleiferous trichomes. The nectary of B. saltatorium is borne on the labellum and is represented by a deep, narrow, median longitudinal groove, having a small aperture, and flanked by trichomes...
September 24, 2017: Protoplasma
https://www.readbyqxmd.com/read/28944135/management-of-syndromic-diarrhea-tricho-hepato-enteric-syndrome-a-review-of-the-literature
#4
REVIEW
Alexandre Fabre, Patrice Bourgeois, Marie-Edith Coste, Céline Roman, Vincent Barlogis, Catherine Badens
Syndromic diarrhea/tricho-hepato-enteric syndrome (SD/THE) is a rare disease linked to the loss of function of either TTC37 or SKIV2L, two components of the SKI complex. It is characterized by a combination of 9 signs (intractable diarrhea, hair abnormalities, facial dysmorphism, immune abnormalities, IUGR/SGA, liver abnormalities, skin abnormalities, congenital heart defect and platelet abnormalities). We present a comprehensive review of the management of SD/THE and tested therapeutic regimens. A review of the literature was conducted in May 2017: 29 articles and 2 abstracts were included describing a total of 80 patients, of which 40 presented with mutations of TTC37, 14 of SKIV2L...
August 2017: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/28942365/nf-%C3%AE%C2%BAb-participates-in-mouse-hair-cycle-control-and-plays-distinct-roles-in-the-various-pelage-hair-follicle-types
#5
Karsten Krieger, Sarah E Millar, Nadine Mikuda, Inge Krahn, Jennifer E Kloepper, Marta Bertolini, Claus Scheidereit, Ralf Paus, Ruth Schmidt-Ullrich
The transcription factor NF-κB controls key features of hair follicle (HF) development, but the role of NF-κB in adult HF cycle regulation remains obscure. Using NF-κB reporter mouse models, strong NF-κB activity was detected in the secondary hair germ (SHG) of late telogen and early anagen HFs, suggesting a potential role for NF-κB in HF stem/progenitor cell activation during anagen induction. At mid-anagen, NF-κB activity was observed in the inner root sheath (IRS) and unilaterally clustered in the HF matrix, which indicates that NF-κB activity is also involved in hair fiber morphogenesis during HF cycling...
September 20, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28942294/histopathological-and-immunohistochemical-study-of-trichoblastoma-in-the-rabbit
#6
M K Kok, J K Chambers, N Ushio, A Watamori, Y Miwa, H Nakayama, K Uchida
Trichoblastoma is the most common skin tumour in the rabbit. The aim of the present study was to characterize the histological and immunohistochemical features of trichoblastoma in 27 rabbits. Common sites of tumour occurrence were the neck (6/30, 20%), head (5/30, 16.7%), flank (4/30, 13.3%) and hindlimb (4/30, 13.3%). Histologically, rabbit trichoblastoma was categorized into ribbon (10/30, 33.3%), trabecular (8/30, 26.7%) and mixed types (12/30, 40%). The tumour tissue showed close interaction with the surrounding stroma where prominent fibroblastic aggregation, known as papillary mesenchymal bodies, was frequently observed (24/30; 80%)...
August 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28940785/transglutaminases-in-autoimmune-and-inherited-skin-diseases-the-phenomena-of-epitope-spreading-and-functional-compensation
#7
REVIEW
Sarolta Kárpáti, Miklós Sárdy, Krisztián Németh, Balázs Mayer, Neil Smyth, Mats Paulsson, Heiko Traupe
Transglutaminases (TGs) are structurally and functionally related enzymes that modify the posttranslational structure and activity of proteins or peptides, and thus are able to turn on or switch off their function. Depending on location and activities, TGs are able to modify the signaling, the function and the fate of cells and extracellular connective tissues. Beside mouse models also human diseases enable us to appreciate the function of various TGs. In this paper skin diseases induced by genetic damages or autoimmune targeting of these enzymes will be discussed...
September 23, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28940653/the-clinicoaetiological-hormonal-and-histopathological-characteristics-of-melasma-in-men
#8
S Handa, D De, G Khullar, B D Radotra, N Sachdeva
BACKGROUND: Melasma is relatively uncommon in males, and there is a paucity of data on male melasma, including its clinical pattern, triggering factors, endocrine profile and histopathological findings. AIM: To characterize the clinical findings and aetiological factors, including hormonal and histopathological features, of male melasma. METHODS: Male patients with melasma and age- and sex-matched healthy controls (HCs) were recruited. Demographic profile, risk factors, clinical pattern and Wood lamp findings of patients were recorded...
September 22, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28939680/mobilizing-transit-amplifying-cell-derived-ectopic-progenitors-prevents-hair-loss-from-chemotherapy-or-radiation-therapy
#9
Wen-Yen Huang, Shih-Fan Lai, Hsien-Yi Chiu, Michael Chang, Maksim Plikus, Chih-Chieh Chan, You-Tzung Chen, Po-Nien Tsao, Tsung-Lin Yang, Hsuan-Shu Lee, Peter Chi, Sung-Jan Lin
Genotoxicity-induced hair loss from chemotherapy and radiotherapy is often encountered in cancer treatment, and there is a lack of effective treatment. In growing hair follicles (HF), quiescent stem cells (SC) are maintained in the bulge region and hair bulbs at the base contain rapidly dividing, yet genotoxicity-sensitive transit-amplifying cells (TAC) that maintain hair growth. How genotoxicity-induced HF injury is repaired remains unclear. We report here that HF mobilize ectopic progenitors from distinct TAC compartments for regeneration in adaptation to the severity of dystrophy induced by ionizing radiation (IR)...
September 22, 2017: Cancer Research
https://www.readbyqxmd.com/read/28937389/incontinentia-pigmenti-an-x-linked-dominant-disorder-in-a-2-year-old-boy-with-klinefelter-syndrome
#10
Abhilasha Williams, Laxmisha Chandrashekar, Vivi M Srivastava, Meera Thomas, Saban Horo, Renu George
Incontinentia pigmenti (IP) is a rare X-linked dominant disorder, in which skin lesions distributed along Blaschko's lines appear shortly after birth. Early lesions which are erythematous/bullous evolve over time into warty lesions, hyperpigmented swirls/macules, and atrophic hypopigmented streaks. Clinical features are heterogeneous. Abnormalities of the teeth, nails, hair, eyes, central nervous system, and breast may also be present. While intelligence is generally normal, varied degrees of intellectual disability/developmental delay have been reported...
July 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28935970/negative-membrane-capacitance-of-outer-hair-cells-electromechanical-coupling-near-resonance
#11
Kuni H Iwasa
Outer hair cells in the cochlea have a unique motility in their cell body based on mechanoelectric coupling, with which voltage changes generated by stimuli at their hair bundles drive the cell body and, in turn, it has been assumed, amplifies the signal. In vitro experiments show that the movement of the charges of the motile element significantly increases the membrane capacitance, contributing to the attenuation of the driving voltage. That is indeed the case in the absence of mechanical load. Here it is predicted, however, that the movement of motile charges creates negative capacitance near the condition of mechanical resonance, such as those in the cochlea, enhancing energy output...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28934520/damage-of-inner-ear-sensory-hair-cells-via-mitochondrial-loss-in-a-murine-model-of-sleep-apnea-with-chronic-intermittent-hypoxia
#12
Young Joon Seo, Hyun Mi Ju, Sun Hee Lee, Sang Hyun Kwak, Min Jung Kang, Joo-Heon Yoon, Chang-Hoon Kim, Hyung-Ju Cho
Study Objectives: Investigating the exact pathophysiology of obstructive sleep apnea syndrome (OSAS)-induced hearing loss is critical. We sought to verify the hypothesis that a correlation exists between mitochondrial dysfunction in inner ear hair cells and the auditory dysfunction induced by chronic intermittent hypoxia (CIH) in a murine model of sleep apnea. Methods: C57BL/6J adult male mice were randomized to 4 weeks of CIH (n = 12) or normoxia (Sham) (n = 12)...
September 1, 2017: Sleep
https://www.readbyqxmd.com/read/28932937/foxn1-deficiency-from-the-discovery-to-novel-therapeutic-approaches
#13
REVIEW
Vera Gallo, Emilia Cirillo, Giuliana Giardino, Claudio Pignata
Since the discovery of FOXN1 deficiency, the human counterpart of the nude mouse, a growing body of evidence investigating the role of FOXN1 in thymus and skin, has been published. FOXN1 has emerged as fundamental for thymus development, function, and homeostasis, representing the master regulator of thymic epithelial and T cell development. In the skin, it also plays a pivotal role in keratinocytes and hair follicle cell differentiation, although the underlying molecular mechanisms still remain to be fully elucidated...
September 21, 2017: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/28932061/epidermal-cysts-a-clinicopathological-analysis-with-emphasis-on-unusual-findings
#14
Jitendra Singh Nigam, Jyotsna Naresh Bharti, Vivek Nair, Chitrawati Bal Gargade, Archana Hemant Deshpande, Biswajit Dey, Ashok Singh
BACKGROUND: Epidermoid cysts, one of the common benign intradermal or subcutaneous tumors commonly result from the trauma to the pilosebaceous unit in the hair bearing area. In areas without hair, these cysts are considered implantation and proliferation of squamous epithelium into the dermis due to injury. AIMS: The aim is to evaluate the clinicopathological details with emphasis on unusual findings related to epidermoid cysts. STUDY DESIGN: This is a retrospective cross-sectional study carried out over 2 years...
July 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/28931742/barn-owls-have-ageless-ears
#15
Bianca Krumm, Georg Klump, Christine Köppl, Ulrike Langemann
We measured the auditory sensitivity of the barn owl (Tyto alba), using a behavioural Go/NoGo paradigm in two different age groups, one younger than 2 years (n = 4) and another more than 13 years of age (n = 3). In addition, we obtained thresholds from one individual aged 23 years, three times during its lifetime. For computing audiograms, we presented test frequencies of between 0.5 and 12 kHz, covering the hearing range of the barn owl. Average thresholds in quiet were below 0 dB sound pressure level (SPL) for frequencies between 1 and 10 kHz...
September 27, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28931463/severe-streptomycin-ototoxicity-in-the-mouse-utricle-leads-to-a-flat-epithelium-but-the-peripheral-neural-degeneration-is-delayed
#16
Guo-Peng Wang, Ishani Basu, Lisa A Beyer, Hiu Tung Wong, Donald L Swiderski, Shu-Sheng Gong, Yehoash Raphael
The damaged vestibular sensory epithelium of mammals has a limited capacity for spontaneous hair cell regeneration, which largely depends on the transdifferentiation of surviving supporting cells. Little is known about the response of vestibular supporting cells to a severe insult. In the present study, we evaluated the impact of a severe ototoxic insult on the histology of utricular supporting cells and the changes in innervation that ensued. We infused a high dose of streptomycin into the mouse posterior semicircular canal to induce a severe lesion in the utricle...
September 11, 2017: Hearing Research
https://www.readbyqxmd.com/read/28929679/-identification-of-six-species-of-medicinal-diospyros-plants-based-on-leaf-macro-and-micro-morphology
#17
Ze Yi, Juan-Juan Qiao, Geng-Yu Lu, Gang Wu, Guo-Yong Xie, Min-Jian Qin
To establish a method for the identification of five species and one variety of medicinal plants from Diospyros, their leaf veins, epidermis, anatomic and powder characters were observed and compared with macro-morphological and microscopic methods. The results indicated the differences of secondary and tertiary veins among those Diospyros species. The single cell non-glandular hair and glandular hair exist in most species' epidermis while stone cells were only found in the leaf powders of two species. Through the study, the main differences of leaf macro- and micro-morphology of these species were obtained and practical keys were also established, which can provide scientific base not only for identification of these species during their vegetative stages, but also for accuracy authentication of the source of Kaki Folium...
November 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28929130/cytoskeletal-stability-in-the-auditory-organ-in-vivo-rhoa-is-dispensable-for-wound-healing-but-essential-for-hair-cell-development
#18
Tommi Anttonen, Ilya Belevich, Maarja Laos, Anni Herranen, Eija Jokitalo, Cord Brakebusch, Ulla Pirvola
Wound healing in the inner ear sensory epithelia is performed by the apical domains of supporting cells (SCs). Junctional F-actin belts of SCs are thin during development but become exceptionally thick during maturation. The functional significance of the thick belts is not fully understood. We have studied the role of F-actin belts during wound healing in the developing and adult cochlea of mice in vivo. We show that the thick belts serve as intracellular scaffolds that preserve the positions of surviving cells in the cochlear sensory epithelium...
September 2017: ENeuro
https://www.readbyqxmd.com/read/28928907/adipose-derived-stromal-cell-in-regenerative-medicine-a-review
#19
REVIEW
Reza Tabatabaei Qomi, Mohsen Sheykhhasan
The application of appropriate cell origin for utilizing in regenerative medicine is the major issue. Various kinds of stem cells have been used for the tissue engineering and regenerative medicine. Such as, several stromal cells have been employed as treat option for regenerative medicine. For example, human bone marrow-derived stromal cells and adipose-derived stromal cells (ADSCs) are used in cell-based therapy. Data relating to the stem cell therapy and processes associated with ADSC has developed remarkably in the past 10 years...
August 26, 2017: World Journal of Stem Cells
https://www.readbyqxmd.com/read/28928635/d-tubocurarine-and-berbamine-alkaloids-that-are-permeant-blockers-of-the-hair-cell-s-mechano-electrical-transducer-channel-and-protect-from-aminoglycoside-toxicity
#20
Nerissa K Kirkwood, Molly O'Reilly, Marco Derudas, Emma J Kenyon, Rosemary Huckvale, Sietse M van Netten, Simon E Ward, Guy P Richardson, Corné J Kros
Aminoglycoside antibiotics are widely used for the treatment of life-threatening bacterial infections, but cause permanent hearing loss in a substantial proportion of treated patients. The sensory hair cells of the inner ear are damaged following entry of these antibiotics via the mechano-electrical transducer (MET) channels located at the tips of the hair cell's stereocilia. d-Tubocurarine (dTC) is a MET channel blocker that reduces the loading of gentamicin-Texas Red (GTTR) into rat cochlear hair cells and protects them from gentamicin treatment...
2017: Frontiers in Cellular Neuroscience
keyword
keyword
31566
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"