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https://www.readbyqxmd.com/read/29130797/dose-finding-study-of-carbamylated-monomeric-allergoid-tablets-in-grass-allergic-rhinoconjunctivitis-patients
#1
Ralph Mösges, Christina Rohdenburg, Andrea Eichel, Gregor Zadoyan, Elena-Manja Kasche, Kija Shah-Hosseini, Walter Lehmacher, Petra Schmalz, Enrico Compalati
AIM: To determine the optimal effective and safe dose of sublingual immunotherapy tablets containing carbamylated monomeric allergoids in patients with grass pollen-induced allergic rhinoconjunctivitis. METHODS: In this prospective, randomized, double-blind, active-controlled, multicenter, Phase II study, four different daily doses were applied preseasonally for 12 weeks. RESULTS: Of 158 randomized adults, 155 subjects (safety population) received 300 units of allergy (UA)/day (n = 36), 600 UA/day (n = 43), 1000 UA/day (n = 39), or 2000 UA/day (n = 37)...
November 2017: Immunotherapy
https://www.readbyqxmd.com/read/29113807/cyanate-improves-insulin-sensitivity-and-hepatic-steatosis-in-normal-and-high-fat-fed-mice-anorexic-and-antioxidative-effects
#2
Seong Sik Kang, Kyo-Cheol Mun, Ji Hae Seo, Misun Choe, Eunyoung Ha
Obesity is an important contributing factor to progression of chronic kidney disease. Cyanate, known as uremic toxin, is an electrophile produced spontaneously from urea or by myeloperoxidase-catalyzed oxidation of thiocyanate. Herein, we explored metabolic effects of cyanate in normal chow diet (NCD)- and high fat diet (HFD)-fed mice. Mice were treated with cyanate (1 mg/mL in drinking water) and fed NCD or HFD. Peritoneal glucose tolerance test (PGTT) and insulin tolerance test (ITT) were performed. Blood urea nitrogen (BUN) and creatinine concentrations were determined...
November 4, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29107336/citrulline-in-health-and-disease-review-on-human-studies
#3
REVIEW
Cinzia Papadia, Sylwia Osowska, Luc Cynober, Alastair Forbes
The amino acid L-citrulline (CIT) is safely used from the neonatal period onwards in those with urea cycle defects and carbamyl phosphate synthetase or ornithine transcarbamylase deficiencies, but several lines of enquiry indicate that it might have a much wider therapeutic role. When protein intake is low and there is a catabolic state, endogenous arginine (ARG) synthesis cannot fully be met and its supplementation can prove challenging, particularly in patients with critical and multisystem illness. Supplementary CIT could constitute a safer but still focused means of delivering ARG to endothelial and immune cells as CIT is efficiently recycled into these cells and as kidneys can convert CIT into ARG...
October 16, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29100671/-nettling-the-host-breaking-of-tolerance-in-chronic-inflammation-and-chronic-infection
#4
REVIEW
Sladjana Skopelja-Gardner, Jonathan D Jones, William F C Rigby
How and why we break tolerance to self-proteins still remains a largely unanswered question. Neutrophils have been identified as a rich source of autoantigens in a wide array of autoimmune diseases that arise as a consequence of different environmental and genetic factors, e.g. rheumatoid arthritis (RA), lupus, vasculitis, cystic fibrosis (CF) etc. Specifically, neutrophil extracellular trap (NET) formation has been identified as a link between innate and adaptive immune responses in autoimmunity. Autoantigens including neutrophil granular proteins (targeted by anti-neutrophil cytoplasmic antibodies, ANCA) as well as post-translationally modified proteins, i...
October 31, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/29096669/anti-carbamylated-protein-antibodies-precede-disease-onset-in-monkeys-with-collagen-induced-arthritis
#5
Marije K Verheul, Michel P M Vierboom, Bert A 't Hart, Rene E M Toes, Leendert A Trouw
BACKGROUND: Rheumatoid factor (RF), anti-citrullinated protein antibodies (ACPA) and anti-carbamylated protein (anti-CarP) antibodies are rheumatoid arthritis (RA)-associated autoantibodies. Besides their presence in human serum, anti-CarP antibodies have also been described in rodent models of arthritis, while ACPA are not consistently detectable. Data on these RA-associated autoantibodies in primates are not available. Therefore, we investigated the presence of RF, anti-CarP antibodies and ACPA in rhesus monkeys before and after collagen-induced arthritis immunizations...
November 2, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29044530/gingival-tissue-an-extrasynovial-source-of-malondialdehyde-acetaldehyde-adducts-citrullinated-and-carbamylated-proteins
#6
R Bright, G M Thiele, J Manavis, T R Mikuls, J B Payne, P M Bartold
BACKGROUND AND OBJECTIVE: Postranslational modification of proteins can lead to the production of autoantibodies and loss of immune tolerance. This process has been hypothesised to be a critical factor in the pathogenesis of rheumatoid arthritis. The objective of this study was to demonstrate that inflamed human gingival tissue provides an extrasynovial source of malondialdehyde-acetaldehyde adducts, citrullinated and carbamylated proteins all of which are considered to be linked to the development of rheumatoid arthritis...
October 17, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29035051/integrating-carbamylation-and-ultraviolet-photodissociation-mass-spectrometry-for-middle-down-proteomics
#7
James D Sanders, Sylvester M Greer, Jennifer S Brodbelt
The most popular bottom-up proteomics workflow uses trypsin to enzymatically cleave proteins C-terminal to lysine and arginine residues prior to LCMS/MS analysis of the resulting peptides. The high frequency of these residues generates short peptides, some of which are too small or uninformative for optimal analysis and which potentially contribute to gaps in sequence coverage of proteins. Analysis of larger peptides, termed "middle-down", has the potential to span greater sections of protein sequences if the larger peptides are adequately characterized based on their fragmentation patterns...
November 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29030163/metabolites-related-to-renal-function-immune-activation-and-carbamylation-are-associated-with-muscle-composition-in-older-adults
#8
Michael S Lustgarten, Roger A Fielding
Reduced skeletal muscle density in older adults is associated with insulin resistance, decreased physical function, and an increased all-cause mortality risk. To elucidate mechanisms that may underlie the maintenance of skeletal muscle density, we conducted a secondary analysis of previously published muscle composition and serum metabolomic data in 73 older adults (average age, 78y). Multivariable-adjusted linear regression was used to examine associations between 321 metabolites with muscle composition, defined as the ratio between normal density (NDM) with low density (LDM) thigh muscle cross sectional area (NDM/LDM)...
October 10, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29029341/an-increased-concentration-of-receptor-activator-of-nuclear-factor-kappa-b-ligand-pre-dates-the-onset-of-rheumatoid-arthritis
#9
Linda Johansson, Lisbeth Ärlestig, Heidi Kokkonen, Mikael Brink, Solbritt Rantapää-Dahlqvist
Objectives: RANK ligand (RANKL) is involved in destruction and osteoporosis in RA. In this study, the relationships between RANKL and ACPA, anti-carbamylated protein antibodies (anti-CarP), cytokines and chemokines were analysed in individuals before the onset of RA symptoms, and their associations with radiological findings at disease onset were assessed. Methods: This was a case-control study performed within the Medical Biobank of Northern Sweden that included 470 pre-symptomatic individuals [334 women and 136 men; mean (s...
September 25, 2017: Rheumatology
https://www.readbyqxmd.com/read/28992314/nutritional-therapy-reduces-protein-carbamylation-through-urea-lowering-in-chronic-kidney-disease
#10
Biagio R Di Iorio, Stefania Marzocco, Antonio Bellasi, Emanuele De Simone, Fabrizio Dal Piaz, Maria Teresa Rocchetti, Carmela Cosola, Lucia Di Micco, Loreto Gesualdo
Background: Protein carbamylation is one of the non-enzymatic reactions involved in protein molecular ageing. We sought to investigate the relationship between urea levels and protein carbamylation, and whether a Mediterranean diet (MD) and a very low protein diet (VLPD) reduce protein carbamylation through reduction in urea levels in patients with chronic kidney disease (CKD). Methods: This is a prospective, randomized, crossover controlled trial that investigated 60 patients with CKD grades 3B-4 (46 males, mean age of 67 years)...
July 11, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28985181/binding-of-bromocresol-green-and-bromocresol-purple-to-albumin-in-hemodialysis-patients
#11
Sigurd Delanghe, Wim Van Biesen, Nadeige Van de Velde, Sunny Eloot, Anneleen Pletinck, Eva Schepers, Griet Glorieux, Joris R Delanghe, Marijn M Speeckaert
BACKGROUND: Colorimetric albumin assays based on binding to bromocresol purple (BCP) and bromocresol green (BCG) yield different results in chronic kidney disease. Altered dye binding of carbamylated albumin has been suggested as a cause. In the present study, a detailed analysis was carried out in which uremic toxins, acute phase proteins and Kt/V, a parameter describing hemodialysis efficiency, were compared with colorimetrically assayed (BCP and BCG) serum albumin. METHODS: Albumin was assayed using immunonephelometry on a BN II nephelometer and colorimetrically based on, respectively, BCP and BCG on a Modular P analyzer...
October 6, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28968865/the-risk-of-individual-autoantibodies-autoantibody-combinations-and-levels-for-arthritis-development-in-clinically-suspect-arthralgia
#12
Robin M Ten Brinck, Hanna W van Steenbergen, Myrthe A M van Delft, Marije K Verheul, Rene E M Toes, Leendert A Trouw, Annette H M van der Helm-van Mil
Objectives: Autoantibody testing is helpful for predicting the risk of progression to clinical arthritis in subjects at risk. Previous longitudinal studies have mainly selected autoantibody-positive arthralgia patients, and consequently the predictive values of autoantibodies were evaluated relative to one another. This study assessed the risks for arthritis development of ACPA, RF and/or anti-carbamylated protein antibodies (anti-CarP) in arthralgia patients considered at risk for RA by rheumatologists, based on clinical characteristics (clinically suspect arthralgia, CSA)...
September 11, 2017: Rheumatology
https://www.readbyqxmd.com/read/28943354/hydroxyhomocitrulline-is-a-collagen-specific-carbamylation-mark-that-affects-cross-link-formation
#13
Yuki Taga, Keisuke Tanaka, Chieko Hamada, Masashi Kusubata, Kiyoko Ogawa-Goto, Shunji Hattori
Carbamylation is a non-enzymatic post-translational modification that physiologically occurs during aging and is a risk factor for various diseases. The most common product of carbamylation is homocitrulline (HCit), where a lysine (Lys) amino group has reacted with urea-derived cyanate. HCit has recently been detected in collagen; however, given that 15%-90% of total Lys in collagen is hydroxylated, it is unclear how hydroxylation affects collagen carbamylation. Here, we identified a collagen-specific carbamylation product, hydroxyhomocitrulline (HHCit), and showed that high levels of HHCit are correlated with age in rat tissue collagen and in vivo carbamylation in mice, as well as with the decline of kidney function in the serum of dialysis patients...
October 19, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/28937640/solvent-free-synthesis-and-safener-activity-of-sulfonylurea-benzothiazolines
#14
Ying Fu, Jing-Yi Wang, Dong Zhang, Yu-Feng Chen, Shuang Gao, Li-Xia Zhao, Fei Ye
A series of novel sulfonylurea benzothiazolines was designed by splicing active groups and bioisosterism. A solvent-free synthetic route was developed for the sulfonylurea benzothiazoline derivatives via the cyclization and carbamylation. All compounds were characterized by IR, ¹H-NMR, (13)C-NMR, HRMS. The biological activity tests indicated the compounds could protect maize against the injury caused by chlorsulfuron to some extent. The molecular docking result showed that the new compound competed with chlorsulfuron to bind with the herbicide target enzyme active site to attain detoxification...
September 22, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28931886/value-of-measuring-anti-carbamylated-protein-antibodies-for-classification-on-early-arthritis-patients
#15
Cristina Regueiro, Laura Nuño, Ana M Ortiz, Diana Peiteado, Alejandro Villalba, Dora Pascual-Salcedo, Ana Martínez-Feito, Isidoro González-Alvaro, Alejandro Balsa, Antonio González
Classification of patients with rheumatoid arthritis (RA) as quickly as possible improves their prognosis. This reason motivates specially dedicated early arthritis (EA) clinics. Here, we have used 1062 EA patients with two years of follow-up to explore the value of anti-carbamylated protein (anti-CarP) antibodies, a new type of RA specific autoantibodies, for classification. Specifically, we aimed to determine whether the addition of anti-CarP antibodies to IgM rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) antibodies, which are helpful in RA classification, improves it or not...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28904872/treatment-of-renal-anemia-erythropoiesis-stimulating-agents-and-beyond
#16
REVIEW
Patrick Biggar, Gheun-Ho Kim
Anemia, complicating the course of chronic kidney disease, is a significant parameter, whether interpreted as subjective impairment or an objective prognostic marker. Renal anemia is predominantly due to relative erythropoietin (EPO) deficiency. EPO inhibits apoptosis of erythrocyte precursors. Studies using EPO substitution have shown that increasing hemoglobin (Hb) levels up to 10-11 g/dL is associated with clinical improvement. However, it has not been unequivocally proven that further intensification of erythropoiesis stimulating agent (ESA) therapy actually leads to a comprehensive benefit for the patient, especially as ESAs are potentially associated with increased cerebro-cardiovascular events...
September 2017: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/28889152/anti-carbamylated-protein-antibodies-in-rheumatoid-arthritis-patients-and-their-association-with-rheumatoid-factor
#17
Maizatul A Othman, Wan Syamimee W Ghazali, Wan Zuraida W A Hamid, Kah K Wong, Nurul K Yahya
To evaluate levels of anti-carbamylated protein (anti-CarP) antibodies in rheumatoid arthritis (RA) patients and to determine their association with serological parameters and disease activity. Methods: A cross-sectional study involving 105 multiethnic RA patients (48 rheumatoid factor [RF]-positive and 57 RF-negative patients) was conducted at Hospital Universiti Sains Malaysia, Kelantan, Malaysia, from January 2015 to February 2016. Fifty healthy controls (HCs) were included. C-reactive protein (CRP), RF, anti-cyclic citrullinated peptide (anti-CCP) and anti-CarP antibodies were measured...
September 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28865468/brain-ureido-degenerative-protein-modifications-are-associated-with-neuroinflammation-and-proteinopathy-in-alzheimer-s-disease-with-cerebrovascular-disease
#18
Xavier Gallart-Palau, Aida Serra, Benjamin Sian Teck Lee, Xue Guo, Siu Kwan Sze
BACKGROUND: Brain degenerative protein modifications (DPMs) are associated with the apparition and progression of dementia, and at the same time, Alzheimer's disease with cerebrovascular disease (AD + CVD) is the most prevalent form of dementia in the elder population. Thus, understanding the role(s) of brain DPMs in this dementia subtype may provide novel insight on the disease pathogenesis and may aid on the development of novel diagnostic and therapeutic tools. Two essential DPMs known to promote inflammation in several human diseases are the ureido DPMs (uDPMs) arginine citrullination and lysine carbamylation, although they have distinct enzymatic and non-enzymatic origins, respectively...
September 2, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28864665/the-clinical-and-research-implications-of-anti-carbamylated-protein-antibodies
#19
EDITORIAL
M Kristen Demoruelle
No abstract text is available yet for this article.
September 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28853240/anti-carbamylated-protein-antibodies-presence-in-early-arthritis-with-a-poorer-clinical-and-radiological-outcome-data-from-the-french-espoir-cohort
#20
Marie-Elise Truchetet, Stéphanie Dublanc, Thomas Barnetche, Olivier Vittecoq, Xavier Mariette, Christophe Richez, Patrick Blanco, Michael Mahler, Cécile Contin-Bordes, Thierry Schaeverbeke
OBJECTIVES: To assess the prevalence of anti-carbamylated protein (CarP) antibodies in a French cohort of early arthritis and to investigate their association with clinical features, final diagnosis, prognosis and comorbidities. METHODS: The presence of anti-CarP antibodies among patients with early arthritis belonging to the ESPOIR French cohort (n=720) was determined using ELISA. We calculated the prevalence of anti-CarP antibodies in different patient subgroups that were stratified according to their anti-citrullinated peptides antibodies (ACPA) and/or rheumatoid factor (RF) status...
August 29, 2017: Arthritis & Rheumatology
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