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Obesity paradox

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https://www.readbyqxmd.com/read/28610685/the-overweight-paradox-in-the-prognosis-of-acute-coronary-syndrome-for-patients-with-heart-failure-a-truth-for-all-a-10-year-follow-up-study
#1
Matina Kouvari, Christina Chrysohoou, Eleptherios Tsiamis, Hara Kosyfa, Lemonia Kalogirou, Androniki Filippou, Stelios Iosifidis, Panagiotis Aggelopoulos, Christos Pitsavos, Dimitris Tousoulis
OBJECTIVES: In established acute coronary syndrome (ACS) with major complications (i.e. heart failure), overweight/obese patients usually have a survival advantage. To what extent this is irrespective of other characteristics remains inconclusive. The role of body mass index (BMI) in ACS prognosis (fatal/recurrent non-fatal cardiac episodes) and background potential interactions were evaluated. STUDY DESIGN: In 2006-2009, 1000 consecutive patients, hospitalized at First Cardiology Clinic of Athens with a diagnosis of ACS were enrolled in the study...
August 2017: Maturitas
https://www.readbyqxmd.com/read/28601194/relation-between-obesity-and-survival-in-patients-hospitalized-for-pulmonary-arterial-hypertension-from-a-nationwide-inpatient-sample-database-2003-to-2011
#2
Manyoo Agarwal, Sahil Agrawal, Lohit Garg, Carl J Lavie
There have been numerous studies reporting lower mortality rates in obese patients with various cardiovascular disorders than in nonobese patients, a phenomenon known as the "obesity paradox." Limited data exist regarding the effect of obesity on prognosis in patients with pulmonary arterial hypertension (PAH). We used the National Inpatient Sample database for years 2003 to 2011 to identify all patient hospitalizations aged ≥18 years with a primary diagnosis of PAH. Patients with a diagnosis of obesity were identified using Elixhauser co-morbidity measure provided in Nationwide Inpatient Sample database, based on International Classification of Diseases, Ninth Revision, Clinical Modification, codes and the diagnosis-related groups...
May 11, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28595816/impact-of-body-mass-index-on-the-short-term-outcomes-of-resected-gastrointestinal-stromal-tumors
#3
Zachary E Stiles, Tyler M Rist, Paxton V Dickson, Evan S Glazer, Martin D Fleming, David Shibata, Jeremiah L Deneve
BACKGROUND: Potentially curative treatment for gastrointestinal stromal tumors (GIST) involves resection with selective utilization of tyrosine kinase inhibitors. A potential association between obesity and GIST has been postulated as GIST is among the most common incidental findings during gastric resection for bariatric procedures. The purpose of this study is to investigate the relationship and impact of obesity on the pathologic and short-term outcomes in patients with GIST. METHODS: We performed a retrospective review of patients with resected GIST...
May 10, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28593612/an-obesity-paradox-increased-body-mass-index-is-associated-with-decreased-aortic-atherosclerosis
#4
REVIEW
Rolf F Barth, L Maximilian Buja, Lei Cao, Sergey V Brodsky
Brodsky et al. (Cardiovasc Pathol 25(6), 515-520, 2016) recently have reported that there was an unexpected and highly significant inverse correlation between body mass index (BMI) and atherosclerosis of the aortas of morbidly obese decedents (BMI >40 kg/m(2)). In a series of 304 decedents, 65 of whom were morbidly obese, minimal or no atherosclerosis was seen in 46 of them (70%) versus 20 (30%) who had severe atherosclerosis (P = 0.008). This obesity paradox was unexpected and raises important questions about the etiology and pathogenesis of atherosclerosis, which will be the subject of this commentary...
July 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28592783/association-of-optimal-combination-drug-treatment-with-obesity-status-among-recent-ischemic-stroke-patients-results-of-the-vitamin-intervention-for-stroke-prevention-visp-trial
#5
Jong-Ho Park, Juneyoung Lee, Bruce Ovbiagele
BACKGROUND AND PURPOSE: One explanation for the 'obesity paradox', where obese patients seem to have better cardiovascular outcomes than lean patients, is that obese patients display an identifiable high cardiovascular risk phenotype that may lead to receiving or seeking earlier/more aggressive treatment. METHODS: We analyzed a clinical trial dataset comprising 3643 recent (<120 days) ischemic stroke patients followed up for 2 years. Subjects were categorized as lean (body mass index [BMI], <25 kg/m(2), n=1,006), overweight (25-29...
May 2017: Journal of Stroke
https://www.readbyqxmd.com/read/28588582/nanoparticle-based-magnetic-resonance-imaging-on-tumor-associated-macrophages-and-inflammation
#6
REVIEW
Natalie J Serkova
The inflammatory response, mediated by tissue-resident or newly recruited macrophages, is an underlying pathophysiological condition for many diseases, including diabetes, obesity, neurodegeneration, atherosclerosis, and cancer. Paradoxically, inflammation is a double-edged sword in oncology. Macrophages are, generally speaking, the major drivers of inflammatory insult. For many solid tumors, high density of cells expressing macrophage-associated markers have generally been found in association with a poor clinical outcome, characterized by inflamed microenvironment, a high level of dissemination and resistance to conventional chemotherapies...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28588319/subcutaneous-adiposity-is-an-independent-predictor-of-mortality-in-cancer-patients
#7
Maryam Ebadi, Lisa Martin, Sunita Ghosh, Catherine J Field, Richard Lehner, Vickie E Baracos, Vera C Mazurak
BACKGROUND: Prognostic significance of adiposity, at the time of cancer diagnosis, on survival is not clear. Body mass index (kg m(-2)) does not provide an appropriate assessment of body composition; therefore, the concept of the 'obesity paradox' needs to be investigated based on the prognostic significance of fat and muscle. Independent prognostic significance of adipose tissue in predicting mortality, importance of visceral and subcutaneous adiposity in the presence and absence of sarcopenia on survival, was investigated...
June 6, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28584251/the-obesity-paradox-may-not-be-a-paradox-at-all
#8
EDITORIAL
H R Banack, A Stokes
No abstract text is available yet for this article.
June 6, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28582523/the-interplay-between-adipose-tissue-and-the-cardiovascular-system-is-fat-always-bad
#9
Ioannis Akoumianakis, Charalambos Antoniades
Obesity is a risk factor for cardiovascular disease (CVD). However, clinical research has revealed a paradoxically protective role for obesity in patients with chronic diseases including CVD, suggesting that the biological "quality" of adipose tissue (AT) may be more important than overall AT mass or body weight. Importantly, AT is recognized as a dynamic organ secreting a wide range of biologically active adipokines, microRNAs, gaseous messengers and other metabolites that affect the cardiovascular system in both endocrine and paracrine ways...
June 5, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28576906/factors-associated-with-frailty-and-its-trajectory-among-patients-on-hemodialysis
#10
Kirsten L Johansen, Lorien S Dalrymple, Cynthia Delgado, Glenn M Chertow, Mark R Segal, Janet Chiang, Barbara Grimes, George A Kaysen
BACKGROUND AND OBJECTIVES: Frailty is common among patients on hemodialysis and associated with adverse outcomes. However, little is known about changes in frailty over time and the factors associated with those changes. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: To address these questions, we examined 762 participants in the A Cohort to Investigate the Value of Exercise/Analyses Designed to Investigate the Paradox of Obesity and Survival in ESRD cohort study, among whom frailty was assessed at baseline and 12 and 24 months...
June 2, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28574920/asking-too-much-of-epidemiologic-studies-the-problem-of-collider-bias-and-the-obesity-paradox
#11
Stijn Vansteelandt
No abstract text is available yet for this article.
May 26, 2017: Epidemiology
https://www.readbyqxmd.com/read/28574919/re-collider-bias-is-only-a-partial-explanation-for-the-obesity-paradox
#12
Vivian Viallon, Marine Dufournet
No abstract text is available yet for this article.
May 26, 2017: Epidemiology
https://www.readbyqxmd.com/read/28574918/response-to-can-collider-bias-fully-explain-the-obesity-paradox
#13
Matthew Sperrin, Jane Candlish, Ellena Badrick, Andrew Renehan, Iain Buchan
No abstract text is available yet for this article.
May 26, 2017: Epidemiology
https://www.readbyqxmd.com/read/28549096/the-molecular-mechanisms-of-obesity-paradox
#14
Alexios S Antonopoulos, Dimitris Tousoulis
Clinical observations suggest a complex relationship between human obesity and cardiovascular disease. Whilst abdominal (visceral) adiposity leads to deleterious metabolic disturbances, subcutaneous fat accumulation has a benign effect on cardiometabolic risk. Notably, an accumulating body of evidence paradoxically links increased body mass index with a better prognosis in patients with established cardiovascular disease, a finding that has been termed the 'obesity paradox'. While this is now acknowledged to be an epidemiological finding, a metabolically healthy obese group associated with low cardiovascular risk has also been identified...
May 26, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28548286/obesity-gets-on-your-renal-nerves
#15
EDITORIAL
B L Jensen
No abstract text is available yet for this article.
May 26, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28536936/effect-of-body-mass-index-on-clinical-outcome-and-all-cause-mortality-in-patients-undergoing-transcatheter-aortic-valve-implantation
#16
M Abawi, R Rozemeijer, P Agostoni, R C van Jaarsveld, C S van Dongen, M Voskuil, A O Kraaijeveld, P A F M Doevendans, P R Stella
OBJECTIVES: To assess the effect of body mass index (BMI) on outcome among patients with severe aortic stenosis (AS) admitted for transcatheter aortic valve implantation (TAVI). BACKGROUND: Being overweight or obese is associated with improved outcome following certain medical treatments, suggesting the existence of a BMI paradox. However, the relationship between BMI and mortality after TAVI remains controversial. METHODS: Patients were classified according to World Health Organisation criteria such as normal weight, overweight, or obesity according to their BMI (18...
May 23, 2017: Netherlands Heart Journal
https://www.readbyqxmd.com/read/28532465/obesity-and-survival-in-critically-ill-patients-with-acute-respiratory-distress-syndrome-a-paradox-within-the-paradox
#17
EDITORIAL
Lorenzo Ball, Ary Serpa Neto, Paolo Pelosi
No abstract text is available yet for this article.
May 3, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28531635/obesity-paradox-in-elderly-patients-with-cardiac-failure-an-updated-review-of-current-evidence
#18
Ioannis Doundoulakis, Kalliopi-Anna Poulia, Christina Antza, Eirini Kasapidou, Michael Chourdakis
No abstract text is available yet for this article.
June 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28529499/exercise-and-glycemic-control-focus-on-redox-homeostasis-and-redox-sensitive-protein-signaling
#19
REVIEW
Lewan Parker, Christopher S Shaw, Nigel K Stepto, Itamar Levinger
Physical inactivity, excess energy consumption, and obesity are associated with elevated systemic oxidative stress and the sustained activation of redox-sensitive stress-activated protein kinase (SAPK) and mitogen-activated protein kinase signaling pathways. Sustained SAPK activation leads to aberrant insulin signaling, impaired glycemic control, and the development and progression of cardiometabolic disease. Paradoxically, acute exercise transiently increases oxidative stress and SAPK signaling, yet postexercise glycemic control and skeletal muscle function are enhanced...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28506965/explaining-the-obesity-paradox-the-association-between-body-composition-and-colorectal-cancer-survival-c-scans-study
#20
Bette J Caan, Jeffrey A Meyerhardt, Candyce H Kroenke, Stacey Alexeeff, Jingjie Xiao, Erin Weltzien, Elizabeth Cespedes Feliciano, Adrienne L Castillo, Charles P Quesenberry, Marilyn L Kwan, Carla M Prado
Background: Body composition may partially explain the U-shaped association between body mass index (BMI) and colorectal cancer survival.Methods: Muscle and adiposity at colorectal cancer diagnosis and survival were examined in a retrospective cohort using Kaplan-Meier curves, multivariable Cox regression, and restricted cubic splines in 3,262 early-stage (I-III) male (50%) and female (50%) patients. Sarcopenia was defined using optimal stratification and sex- and BMI-specific cut points. High adiposity was defined as the highest tertile of sex-specific total adipose tissue (TAT)...
May 15, 2017: Cancer Epidemiology, Biomarkers & Prevention
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