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Obesity paradox

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https://www.readbyqxmd.com/read/29468911/reality-of-obesity-paradox-results-of-percutaneous-coronary-intervention-in-middle-eastern-patients
#1
Mohamad Jarrah, Ayman J Hammoudeh, Yousef Khader, Ramzi Tabbalat, Eyas Al-Mousa, Osama Okkeh, Imad A Alhaddad, Loai Issa Tawalbeh, Issa M Hweidi
Objective The aim of this study was to assess the baseline clinical characteristics, coronary angiographic features, and adverse cardiovascular events during hospitalization and at 1 year of follow-up in obese patients compared with overweight and normal/underweight patients. Methods A prospective, multicenter study of consecutive patients undergoing percutaneous coronary intervention was performed. Results Of 2425 enrolled patients, 699 (28.8%) were obese, 1178 (48.6%) were overweight, and 548 (22.6%) were normal/underweight...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29461311/looking-for-food-food-access-food-insecurity-and-the-food-environment-in-rural-mississippi
#2
Leslie H Hossfeld, Gina Rico Mendez
Mississippi has the highest food insecurity rate in the nation, and while the overall pattern of food insecurity has declined in the United States, for Mississippians it has plateaued, remaining significantly higher than prerecession rates. In addition, the food environment of the state is characterized by low healthy food access, high persistent poverty, and a primarily rural landscape. This translational research seeks to bridge thinking on agriculture policy, nutrition, food access/food insecurity in seeking to understand the paradox between obesity and poverty in rural Mississippi...
April 2018: Family & Community Health
https://www.readbyqxmd.com/read/29449191/bmi-and-outcomes-in-melanoma-more-evidence-for-the-obesity-paradox
#3
Andrew J Hayes, James Larkin
No abstract text is available yet for this article.
February 12, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29434629/transcatheter-versus-surgical-aortic-valve-replacement-in-severe-symptomatic-aortic-stenosis
#4
REVIEW
Tsigkas Grigorios, Despotopoulos Stefanos, Makris Athanasios, Koniari Ioanna, Armylagos Stylianos, Davlouros Periklis, Hahalis George
Aortic stenosis (AS) is the most common type of valvular heart disease in the elderly. Surgical aortic valve replacement (SAVR) has been the standard practice for treating severe, symptomatic AS, but recently new treatment options have emerged. Transcatheter aortic valve replacement (TAVR) is now an established treatment option in patients at high surgical risk. In this review, we focus on recent developments and compare the two treatment methods in specific populations in terms of efficacy and safety (e.g...
January 2018: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29428438/no-obesity-paradox-in-pediatric-patients-with-dilated-cardiomyopathy
#5
Chesney D Castleberry, John L Jefferies, Ling Shi, James D Wilkinson, Jeffrey A Towbin, Ryan W Harrison, Joseph W Rossano, Elfriede Pahl, Teresa M Lee, Linda J Addonizio, Melanie D Everitt, Justin Godown, Joseph Mahgerefteh, Paolo Rusconi, Charles E Canter, Steven D Colan, Paul F Kantor, Hiedy Razoky, Steven E Lipshultz, Tracie L Miller
OBJECTIVES: This study aimed to examine the role of nutrition in pediatric dilated cardiomyopathy (DCM). BACKGROUND: In adults with DCM, malnutrition is associated with mortality, whereas obesity is associated with survival. METHODS: The National Heart, Lung, and Blood Institute-funded Pediatric Cardiomyopathy Registry was used to identify patients with DCM and categorized by anthropometric measurements: malnourished (MN) (body mass index [BMI] <5% for ≥2 years or weight-for-length <5% for <2 years), obesity (BMI >95% for age ≥2 years or weight-for-length >95% for <2 years), or normal bodyweight (NB)...
February 1, 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/29428437/obesity-and-prognosis-in-pediatric-dilated-cardiomyopathy-no-paradox-or-adverse-effects
#6
EDITORIAL
Carl J Lavie, Hector O Ventura
No abstract text is available yet for this article.
February 1, 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/29428434/impact-of-body-mass-index-on-heart-failure-by-race-ethnicity-from-get-with-the-guidelines-heart-failure-gwtg-hf-registry
#7
Tiffany M Powell-Wiley, Julius Ngwa, Selomie Kebede, Di Lu, Phillip J Schulte, Deepak L Bhatt, Clyde Yancy, Gregg C Fonarow, Michelle A Albert
OBJECTIVES: This study sought to evaluate the influence of race/ethnicity on the relationship between body mass index (BMI) and mortality in heart failure with preserved ejection fraction (HFpEF) and HF with reduced EF (HFrEF) patients. BACKGROUND: Prior studies demonstrated an "obesity paradox" among overweight and obese patients, where they have a better HF prognosis than normal weight patients. Less is known about the relationship between BMI and mortality among diverse patients with HF, particularly given disparities in obesity and HF prevalence...
February 1, 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/29421422/influence-of-body-weight-on-surgical-treatment-for-neurogenic-thoracic-outlet-syndrome
#8
J Westley Ohman, Ahmmad A Abuirqeba, Senthil N Jayarajan, Joshua Balderman, Robert W Thompson
BACKGROUND: Body weight affects outcomes of surgical treatment for various conditions, but its effects on the treatment of neurogenic thoracic outlet syndrome (NTOS) are unknown. The purpose of this study was to evaluate the influence of body weight on technical and functional outcomes of surgical treatment for NTOS. METHODS: A retrospective review of prospectively collected data was conducted for 265 patients that underwent supraclavicular decompression for NTOS between January 1, 2014 and March 31, 2016...
February 5, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29420235/loss-of-mitochondrial-protease-clpp-protects-mice-from-diet-induced-obesity-and-insulin-resistance
#9
Shylesh Bhaskaran, Gavin Pharaoh, Rojina Ranjit, Ashley Murphy, Satoshi Matsuzaki, Binoj C Nair, Brittany Forbes, Suzana Gispert, Georg Auburger, Kenneth M Humphries, Michael Kinter, Timothy M Griffin, Sathyaseelan S Deepa
Caseinolytic peptidase P (ClpP) is a mammalian quality control protease that is proposed to play an important role in the initiation of the mitochondrial unfolded protein response (UPRmt), a retrograde signaling response that helps to maintain mitochondrial protein homeostasis. Mitochondrial dysfunction is associated with the development of metabolic disorders, and to understand the effect of a defective UPRmt on metabolism, ClpP knockout (ClpP-/-) mice were analyzed. ClpP-/- mice fed ad libitum have reduced adiposity and paradoxically improved insulin sensitivity...
February 2, 2018: EMBO Reports
https://www.readbyqxmd.com/read/29419749/deficiency-of-invariant-natural-killer-t-cells-does-not-protect-against-obesity-but-exacerbates-atherosclerosis-in-ldlr-mice
#10
Savitha Subramanian, Leela Goodspeed, Shari Wang, Yilei Ding, Kevin D O'Brien, Godfrey S Getz, Alan Chait, Catherine A Reardon
Obesity is a chronic inflammatory state characterized by altered levels of adipose tissue immune cell populations. Natural killer T (NKT) cells are CD1d restricted lymphocyte subsets that recognize lipid antigens whose level decreases in obese adipose tissue. However, studies in mice with deficiency or increased levels of NKT cells have yielded contradictory results, so the exact role of these cells in obesity and adipose tissue inflammation is not yet established. We previously showed that Ldlr-/- mice with excess invariant NKT (iNKT) cells demonstrate significant weight gain, adiposity, metabolic abnormalities, and atherosclerosis...
February 8, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29415663/the-impact-of-disease-severity-on-paradoxical-association-between-body-mass-index-and-mortality-in-patients-with-acute-kidney-injury-undergoing-continuous-renal-replacement-therapy
#11
Hyoungnae Kim, Hyunwook Kim, Misol Lee, Min-Uk Cha, Ki Heon Nam, Seong Yeong An, Su-Young Jung, Jong Hyun Jhee, Seohyun Park, Hae-Ryong Yun, Youn Kyung Kee, Hyung Jung Oh, Jung Tak Park, Tae Ik Chang, Tae-Hyun Yoo, Shin-Wook Kang, Seung Hyeok Han
BACKGROUND: Association between high body mass index (BMI) and survival benefit is confounded by comorbid conditions such as nutritional status and inflammation. Patients with acute kidney injury (AKI), particularly those receiving continuous renal replacement therapy (CRRT), are highly catabolic and more susceptible to loss of energy. Herein, we evaluated whether disease severity can modify the relationship between BMI and mortality. METHODS: We conducted an observational study in 1144 patients who had undergone CRRT owing to various causes of AKI between 2010 and 2014...
February 7, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29414761/global-analyses-of-selective-insulin-resistance-in-hepatocytes-due-to-palmitate-lipotoxicity
#12
Zhihuan Li, Zon Weng Lai, Romain Christiano, Felipe Gazos-Lopes, Tobias C Walther, Robert V Farese
Obesity is tightly linked to hepatic steatosis and insulin resistance. One feature of this association is the paradox of selective insulin resistance: insulin fails to suppress hepatic gluconeogenesis but activates lipid synthesis in the liver. How lipid accumulation interferes selectively with some branches of hepatic insulin signaling is not well understood. Here we provide a resource, based on unbiased approaches and established in a simple cell culture system, to enable investigations of the phenomenon of selective insulin resistance...
February 5, 2018: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29396230/nonlinear-dose-response-association-between-body-mass-index-and-risk-of-all-cause-and-cardiovascular-mortality-in-patients-with-hypertension-a-meta-analysis
#13
REVIEW
Ahmad Jayedi, Sakineh Shab-Bidar
OBJECTIVE: The present study examined the dose-response association of body mass index (BMI) and risk of all-cause and cardiovascular mortality in patients with existing hypertension. METHOD: A systematic search was done using PubMed and Scopus, from their inception up to January 25, 2017. Prospective and retrospective cohort studies reporting risk estimates of all-cause and cardiovascular mortality for three or more quantitative categories of BMI were included...
January 30, 2018: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/29388820/the-obesity-paradox-in-chronic-obstructive-pulmonary-disease-can-it-be-resolved
#14
Anand S Iyer, Mark T Dransfield
No abstract text is available yet for this article.
February 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29387396/impact-of-body-mass-index-on-clinicopathological-outcomes-in-patients-with-renal-cell-carcinoma-without-anorexia-cachexia-syndrome
#15
Daisuke Watanabe, Akio Horiguchi, Shinsuke Tasaki, Kenji Kuroda, Akinori Sato, Junichi Asakuma, Keiichi Ito, Tomohiko Asano
Although obesity defined by a high body mass index (BMI) is generally associated with increased risk of renal cell carcinoma (RCC), low BMI has paradoxically been associated with increased tumor aggressiveness and poor prognosis. As anorexia-cachexia syndrome (ACS) is associated with decreased BMI and is frequently observed in patients with advanced RCC, the present study investigated the association of BMI with tumor aggressiveness and prognosis in RCC in relation to ACS. The association of BMI with clinicopathological parameters was analyzed in 503 consecutive patients who underwent surgery for RCC...
January 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29385791/the-influence-of-patients-nutritional-status-on-the-prevalence-course-and-treatment-outcomes-of-lower-limb-ischemia-an-overview-of-current-evidence
#16
Marta Spychalska-Zwolińska, Tomasz Zwoliński, Marzena Anaszewicz, Jacek Budzyński
INTRODUCTION: The association of lower limb ischemia (LLI) with disturbances in nutritional status, in respect to over- or undernutrition, is still uncertain. The aim of this study was to present the current state of knowledge on this issue. EVIDENCE ACQUISITION: Systematic review of papers published between 2006 and 2018. EVIDENCE SYNTHESIS: The literature shows inconclusive evidence regarding the impact of nutritional status on the risk, course, prognosis and outcomes of conservative and invasive treatment of LLI...
January 31, 2018: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/29374028/paediatric-obesity-appears-to-lower-the-risk-of-diabetes-if-selection-bias-is-ignored
#17
Steven D Stovitz, Hailey R Banack, Jay S Kaufman
BACKGROUND: Frustrated with the onslaught of articles reporting fascination with results that appear paradoxical but are merely due to selection bias, we studied the apparent effect of obesity on diabetes risk in youth who had a test for diabetes. We hypothesised that obese subjects would have lower rates of diabetes than non-obese subjects due to selection bias, and consequently, obesity would appear to lower the risk of diabetes. METHODS: Retrospective cohort study of children (4-9 years), pre-teens (10-12 years) and teenagers (13-19 years)...
January 26, 2018: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/29370691/autophagy-dysregulation-and-obesity-associated-pathologies
#18
REVIEW
Sim Namkoong, Chun-Seok Cho, Ian Semple, Jun Hee Lee
Autophagy is one of the major degradative mechanisms that can eliminate excessive nutrients, toxic protein aggregates, damaged organelles and invading microorganisms. In response to obesity and obesity-associated lipotoxic, proteotoxic and oxidative stresses, autophagy plays an essential role in maintaining physiological homeostasis. However, obesity and its associated stress insults can often interfere with the autophagic process through various mechanisms, which result in further aggravation of obesity-related metabolic pathologies in multiple metabolic organs...
January 31, 2018: Molecules and Cells
https://www.readbyqxmd.com/read/29364914/relation-of-body-mass-index-to-risk-of-developing-inflammatory-bowel-disease-amongst-women-in-the-danish-national-birth-cohort
#19
Michael Mendall, Maria Christina Harpsøe, Devinder Kumar, Mikael Andersson, Tine Jess
BACKGROUND: Crohn's disease (CD) has traditionally been associated with weight loss and low BMI, yet paradoxically obesity has recently been suggested as a risk factor for CD, but not for ulcerative colitis (UC). We therefore hypothesized that the relation between BMI and CD is U shaped. AIM: To conduct a large population-based prospective cohort study of BMI and later risk of IBD, taking age at IBD diagnosis into account. METHODS: A cohort of 74,512 women from the Danish National Birth Cohort, with BMI measured pre-pregnancy and 18 months after delivery, was followed for 1,022,250 person-years for development of IBD, according to the Danish National Patient Register...
2018: PloS One
https://www.readbyqxmd.com/read/29358509/neurotoxic-chemicals-in-adipose-tissue-a-role-in-puzzling-findings-on-obesity-and-dementia
#20
Duk-Hee Lee, Miquel Porta, Lars Lind, P Monica Lind, David R Jacobs
Midlife obesity is associated with increased risk of dementia, whereas late-life obesity is commonly associated with a lower risk of dementia. Although methodologic issues are often discussed in this apparent risk reversal, chronic exposure to low-dose organochlorine pesticides (OCPs), an emerging risk factor for dementia in general populations, may contribute to a direct explanation for these differences. OCPs are strong lipophilic chemicals with very long half-lives (several years), primarily stored in adipose tissue and very slowly released and metabolized over years...
January 23, 2018: Neurology
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