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Obesity paradox

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https://www.readbyqxmd.com/read/28213000/obesity-is-associated-with-long-term-improved-survival-in-definitively-treated-locally-advanced-non-small-cell-lung-cancer-nsclc
#1
Vincent K Lam, Søren M Bentzen, Pranshu Mohindra, Elizabeth M Nichols, Neha Bhooshan, Melissa Vyfhuis, Katherine A Scilla, Steven J Feigenberg, Martin J Edelman, Josephine L Feliciano
OBJECTIVES: To determine the prognostic effect of Body Mass Index (BMI) in definitively treated locally advanced NSCLC patients. MATERIALS AND METHODS: In this single institution retrospective cohort study, we evaluated 291 patients who were treated for locally advanced NSCLC from 2000 to 2010. They were stratified into four BMI groups based on World Health Organization criteria: underweight (<18.5kg/m2), normal weight (18.5 to <25kg/m2), overweight (25 to <30kg/m2), and obese (≧30kg/m2)...
February 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28209971/obesity-paradox-in-group-1-pulmonary-hypertension-analysis-of-the-nih-pulmonary-hypertension-registry
#2
S Mazimba, E Holland, V Nagarajan, A D Mihalek, J L W Kennedy, K C Bilchick
BACKGROUND: The 'obesity paradox' refers to the fact that obese patients have better outcomes than normal weight patients. This has been observed in multiple cardiovascular conditions, but evidence for obesity paradox in pulmonary hypertension (PH) remains sparse. METHODS: We categorized 267 patients from the NIH PH Registry into five groups based on BMI: underweight, normal weight, overweight, obese, and morbidly obese. Mortality was compared in BMI groups using the chi square statistic...
February 17, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28193372/-scientific-evidence-on-preventive-interventions-in-childhood-obesity
#3
Raquel Alba-Martín
INTRODUCTION: The increasing prevalence of obesity or overweight at all ages, their associated morbidity and mortality associated, and the increased perception of the problem by the society have generated several hypotheses in response to the scientific and the international community. OBJECTIVE: Investigate the preventive interventions in childhood obesity so far. METHODS: Integrative review during the study period from April 2013 to November 2014...
January 2017: Revista Colombiana de Psiquiatría
https://www.readbyqxmd.com/read/28178338/the-impact-of-obesity-and-adiponectin-signaling-in-patients-with-renal-cell-carcinoma-a-potential-mechanism-for-the-obesity-paradox
#4
Ryuichi Ito, Shintaro Narita, Mingguo Huang, Taketoshi Nara, Kazuyuki Numakura, Koichiro Takayama, Hiroshi Tsuruta, Atsushi Maeno, Mitsuru Saito, Takamitsu Inoue, Norihiko Tsuchiya, Shigeru Satoh, Tomonori Habuchi
Although obesity increases the risk of renal cell carcinoma (RCC), obese patients with RCC experience longer survival than non-obese patients. However, the mechanism of this "obesity paradox" is unknown. We examined the impact of preoperative BMI, serum total adiponectin (sAd) level, total adiponectin secretion from perinephric adipose tissue, and intratumoral expression of adiponectin receptors on RCC aggressiveness and survival. We also investigated the mechanism underlying enhanced cancer aggressiveness in RCC cells stimulated with exogenous adiponectin...
2017: PloS One
https://www.readbyqxmd.com/read/28161905/total-and-central-obesity-in-elderly-associated-with-a-marker-of-undernutrition-in-early-life-sitting-height-to-stature-ratio-a-nutritional-paradox
#5
Erika Aparecida Silveira, Carla Cristina da Conceição Ferreira, Valéria Pagotto, Annelisa Silva E Alves de Carvalho Santos, Gustavo Velasquez-Melendez
OBJECTIVES: The purpose of this study was to investigate whether sitting height-to-stature ratio (SHSR) is associated with total and central obesity in the elderly. METHODS: This was a cross-sectional study with 133 noninstitutionalized elderly. High SHSR (≥ 1SD above the mean) was used as a marker of undernutrition (MU) in early life. Poisson's multiple regression was used to determine the association between variables. RESULTS: The prevalence of high SHSR was 21...
February 5, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/28121665/body-mass-index-carotid-plaque-and-clinical-outcomes-in-patients-with-coronary-artery-disease
#6
Hyun Woong Park, Ki-Hong Kim, In Girl Song, Taek-Geun Kwon, Wan Ho Kim, Jang-Ho Bae
OBJECTIVES: We evaluated the relationship among BMI, carotid sonographic findings, and long-term (5 years) cardiovascular events in Asian patients with coronary artery disease (CAD). PATIENTS AND METHODS: The study population consisted of 1342 consecutive patients with CAD, who were stratified into four groups according to weight status, as defined by the WHO for the Asian population: underweight (group I: BMI<18.5 kg/m, n=38); normal weight (group II: 18.5≤BMI<23...
January 31, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28117927/association-between-obesity-and-heart-failure-symptoms-in-male-and-female-patients
#7
S Heo, D K Moser, S J Pressler, S B Dunbar, K S Lee, J Kim, T A Lennie
In patients with heart failure (HF), higher body mass index (BMI) has been associated with lower rates of hospitalization and mortality (obesity paradox). Symptoms are antecedents of hospitalizations, but little is known about the relationship between BMI and symptoms and gender differences. To examine the association of BMI with symptoms in male and female patients with HF, controlling for covariates (sample characteristics, depressive symptoms and sodium intake). In this cross-sectional correlational study, patients (N = 247) provided data on BMI, symptoms and covariates...
January 24, 2017: Clinical Obesity
https://www.readbyqxmd.com/read/28109619/obesity-and-heart-failure-focus-on-the-obesity-paradox
#8
REVIEW
Salvatore Carbone, Carl J Lavie, Ross Arena
The escalating prevalence of obesity has been linked to substantial increases in both metabolic and cardiovascular disease. Nevertheless, the direct effects of obesity on cardiovascular health and function require further exploration. In particular, the relationship between obesity and cardiac function has received intense scrutiny. Although obesity increases the risk for development of heart failure (HF), it appears to exert a protective effect in patients in whom HF has already been diagnosed (the "obesity paradox")...
February 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28100880/significant-association-of-serum-adiponectin-and-creatine-kinase-mb-levels-in-st-segment-elevation-myocardial-infarction
#9
Tomoaki Natsukawa, Norikazu Maeda, Shiro Fukuda, Masaya Yamaoka, Yuya Fujishima, Hirofumi Nagao, Fumi Sato, Hitoshi Nishizawa, Hirotaka Sawano, Yasuyuki Hayashi, Tohru Funahashi, Tatsuro Kai, Iichiro Shimomura
AIMS: Adiponectin, an adipocyte-specific secretory protein, abundantly exists in the blood stream while its concentration paradoxically decreases in obesity. Hypoadiponectinemia is one of risks of cardiovascular diseases. However, impact of serum adiponectin concentration on acute ischemic myocardial damages has not been fully clarified. The present study investigated the association of serum adiponectin and creatine kinase (CK)-MB levels in subjects with ST-segment elevation myocardial infarction (STEMI)...
January 17, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28100429/right-ventricular-function-measured-by-tapse-in-obese-subjects-at-the-time-of-acute-myocardial-infarction-and-2year-outcomes
#10
Yaser S Alhamshari, Talal Alnabelsi, Ramzi Mulki, Beatriz Cepeda-Valery, Vincent M Figueredo, Abel Romero-Corral
INTRODUCTION: Obesity is associated with significantly better outcome after acute myocardial infarction (AMI), a phenomenon known as 'obesity paradox'. Tricuspid annular plane systolic excursion (TAPSE) is an echocardiographic measurement of right ventricular (RV) function and has prognostic implications at the time of AMI. METHODS: We examined the difference in RV function among patients admitted with AMI according to obesity status. In a single center cohort analysis of 105 patients admitted between 2010 and 2011 with the diagnosis of AMI...
January 6, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28100227/prenatal-and-postnatal-mothering-by-diesel-exhaust-pm2-5-exposed-dams-differentially-program-mouse-energy-metabolism
#11
Minjie Chen, Shuai Liang, Huifen Zhou, Yanyi Xu, Xiaobo Qin, Ziying Hu, Xiaoke Wang, Lianglin Qiu, Wanjun Wang, Yuhao Zhang, Zhekang Ying
BACKGROUND: Obesity is one of the leading threats to global public health. It is consequent to abnormal energy metabolism. Currently, it has been well established that maternal exposure to environmental stressors that cause inappropriate fetal development may have long-term adverse effects on offspring energy metabolism in an exposure timing-dependent manner, known as developmental programming of health and diseases paradigm. Rapidly increasing evidence has indicated that maternal exposure to ambient fine particles (PM2...
18, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28094538/the-obesity-paradox-in-colorectal-cancer-surgery-an-analysis-of-korean-healthcare-big-data-2012-2013
#12
Sanghun Lee
Although it is well known that obesity increases the risk of colorectal cancer, several studies have recently suggested that those who are overweight or class-one obese have better outcomes after surgery. However, the impact of obesity on the success of colorectal cancer surgery remains controversial. The medical records of patients diagnosed with colorectal cancer who were treated surgically from 2012 through 2013 were retrospectively analyzed. Data from a total of 36,740 patients were provided by the Healthcare Big Data Hub of the Korean Health Insurance Review & Assessment Service...
January 17, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28092289/the-impact-of-obesity-on-heart-failure
#13
Alexander B Zhai, Haissam Haddad
PURPOSE OF REVIEW: Obesity, a growing global health problem, contributes to the development of heart failure. However, increased BMI seems protective for those with established disease, a phenomenon known as the 'obesity paradox'. In this review, we outline the mechanism through which obesity can contribute to the development of heart failure, explore the concept of obesity paradox, and highlight the challenges that obesity presents for advanced heart failure therapy. RECENT FINDINGS: Although the mechanism underlying the obesity paradox is complex, meta-analysis shows that intentional weight loss through bariatric surgery can indeed improve cardiac structure and function...
March 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/28089155/prognostic-value-of-body-mass-index-in-transcatheter-aortic-valve-implantation-a-j-shaped-curve
#14
Rocío González-Ferreiro, Antonio J Muñoz-García, Diego López-Otero, Pablo Avanzas, Isaac Pascual, Juan H Alonso-Briales, Ramiro Trillo-Nouche, Federico Pun, Manuel F Jiménez-Navarro, José M Hernández-García, César Morís, José R González Juanatey
OBJECTIVES: We aimed to determine whether body mass index (BMI) is a prognostic indicator for long-term, all-cause mortality in patients undergoing transcatheter aortic valve implantation (TAVI). BACKGROUND: Obesity in patients with established cardiovascular disease has previously been identified as an indicator of good prognosis, a phenomenon known as the "obesity paradox". The prognostic significance of BMI in patients with severe aortic stenosis (AoS) undergoing TAVI is a matter of current debate, as published studies are scarce and their results conflicting...
December 21, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28077227/impact-of-nutritional-assessment-and-body-mass-index-on-cardiovascular-outcomes-in-patients-with-stable-coronary-artery-disease
#15
Ayako Kunimura, Hideki Ishii, Tadayuki Uetani, Toshijirou Aoki, Kazuhiro Harada, Kenshi Hirayama, Yosuke Negishi, Yohei Shibata, Takuya Sumi, Kazuhiro Kawashima, Yosuke Tatami, Toshiki Kawamiya, Dai Yamamoto, Susumu Suzuki, Tetsuya Amano, Toyoaki Murohara
BACKGROUND: An inverse association between obesity, as defined by body mass index (BMI) and prognosis has been reported in patients with cardiovascular disease ("obesity paradox"). The aim of this study was to investigate whether adding nutritional information to BMI provides better risk assessment in patients undergoing elective percutaneous coronary intervention (PCI). METHOD: This study comprised 1004 patients undergoing elective PCI. We calculated each patient's controlling nutritional status (CONUT) score for nutritional screening at baseline...
March 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28076839/chemotherapy-can-induce-weight-normalization-of-morbidly-obese-mice-despite-undiminished-ingestion-of-high-fat-diet
#16
Cheryl E Myers, Dominique B Hoelzinger, Tiffany N Truong, Lindsey A Chew, Arpita Myles, Leena Chaudhuri, Jan B Egan, Jun Liu, Sandra J Gendler, Peter A Cohen
Morbidly obese patients who accomplish substantial weight loss often display a long-term decline in their resting metabolism, causing even relatively restrained caloric intake to trigger a relapse to the obese state. Paradoxically, we observed that morbidly obese mice receiving chemotherapy for cancer experienced spontaneous weight reduction despite unabated ingestion of their high fat diet (HFD). This response to chemotherapy could also be achieved in morbidly obese mice without cancer. Optimally dosed methotrexate (MTX) or cyclophosphamide (CY) enabled the mice to completely and safely normalize their body weight despite continued consumption of obesogenic quantities of HFD...
January 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28074616/is-hemodialysis-patient-survival-dependent-upon-small-solute-clearance-kt-v-if-so-how-can-kt-v-be-adjusted-to-prevent-under-dialysis-in-vulnerable-groups
#17
Andrew Davenport
Small solute clearance achieved during a single hemodialysis session has been traditionally evaluated by urea clearance, normalized for total body water (Kt/Vurea) for more than 30 years. By consensus, the target sessional KtVurea for thrice weekly treatments has been increased from 0.9 to 1.2 over the years. Although this is supported by observational studies, there is a fundamental lack of prospective studies to support this threshold target. In clinical practice achieving sessional Kt/Vurea targets are most closely followed in the US...
January 11, 2017: Seminars in Dialysis
https://www.readbyqxmd.com/read/28069728/the-obesity-paradox-in-survival-after-cancer-diagnosis-tools-for-evaluation-of-potential-bias
#18
EDITORIAL
Elizabeth Rose Mayeda, M Maria Glymour
The effects of overweight or obesity on survival after cancer diagnosis are difficult to discern based on observational data because these associations reflect the net impact of both causal and spurious phenomena. We describe two sources of bias that might lead to underestimation of the effect of increased body weight on survival after cancer diagnosis: collider stratification bias and heterogeneity in disease bias. Given the mixed evidence on weight status, weight change, and postdiagnosis survival for cancer patients, systematic evaluation of alternative explanations is critical...
January 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28069727/the-obesity-paradox-in-cancer-moving-beyond-bmi
#19
EDITORIAL
Shlomit Strulov Shachar, Grant R Williams
Body mass index (BMI) and simple counts of weight are easy and available tools in the clinic and in research. Recent studies have shown that cancer patients with a low normal BMI (or those with weight loss) have worse outcomes than obese patients. These results suggest that obesity has a protective effect and has been termed the "obesity paradox." In this commentary, we discuss hypothetical explanations and take a step beyond BMI or simple weights alone to present other useful and more specific body composition metrics, such as muscle tissue mass, visceral fat mass, and subcutaneous fat mass...
January 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28069726/next-steps-in-understanding-the-obesity-paradox-in-cancer
#20
EDITORIAL
Bette J Caan, Candyce H Kroenke
No abstract text is available yet for this article.
January 2017: Cancer Epidemiology, Biomarkers & Prevention
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