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Obesity paradox

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https://www.readbyqxmd.com/read/28306588/is-there-an-obesity-paradox-in-coronary-heart-disease-in-asia
#1
Carl J Lavie, Sergey Kachur, Alban De Schutter
No abstract text is available yet for this article.
March 16, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28291782/obesity-paradox-in-stroke-myth-or-reality-a-systematic-review
#2
Lisa Oesch, Turgut Tatlisumak, Marcel Arnold, Hakan Sarikaya
BACKGROUND AND PURPOSE: Both stroke and obesity show an increasing incidence worldwide. While obesity is an established risk factor for stroke, its influence on outcome in ischemic stroke is less clear. Many studies suggest a better prognosis in obese patients after stroke ("obesity paradox"). This review aims at assessing the clinical outcomes of obese patients after stroke by performing a systematic literature search. METHODS: The reviewers searched MEDLINE from inception to December 2015...
2017: PloS One
https://www.readbyqxmd.com/read/28291623/bmi-is-inversely-correlated-to-the-risk-of-mortality-in-patients-with-type-2-diabetes-hospitalized-for-acute-heart-failure-findings-from-the-gulf-acute-heart-failure-gulf-care-registry
#3
Charbel Abi Khalil, Kadhim Sulaiman, Rajvir Singh, Amin Jayyousi, Nidal Asaad, Khalid F AlHabib, Alawi Alsheikh-Ali, Mohammed Al-Jarallah, Bassam Bulbanat, Wael AlMahmeed, Soha Dargham, Mustafa Ridha, Nooshin Bazargani, Haitham Amin, Ahmed Al-Motarreb, Husam AlFaleh, Abdelfatah Elasfar, Prashanth Panduranga, Jassim Al Suwaidi
BACKGROUND: A U-shaped relationship has been reported between BMI and cardiovascular events among patients with acute heart failure (AHF). We hypothesized that an obesity paradox also governs the relationship between BMI and mortality in patients with type 2 diabetes (T2D) and AHF. METHODS: We studied 3-month and 12-month mortality in patients with T2D hospitalized for AHF according to 5 BMI categories: Underweight (<20kg/m(2)), normal weight (referent group, 20-24...
February 27, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28288028/the-obesity-paradox-is-not-observed-in-critically-ill-patients-on-early-enteral-nutrition
#4
Kimberley Harris, Jiachen Zhou, Xinggang Liu, Erkan Hassan, Omar Badawi
OBJECTIVES: To investigate the association between body mass index and mortality in a large, ICU population and determine if the relationship is observed among a subgroup of patients ordered early enteral nutrition. DESIGN: Retrospective cohort study within a national clinical mixed ICU database of patients admitted between January 1, 2008, and June 30, 2015. SETTING: Initial ICU admissions among patients monitored by tele-ICU programs and recorded in the Philips eICU Research Institute database...
March 10, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28279831/inverse-relationship-between-the-body-mass-index-and-severity-of-carotid-siphon-calcifications-another-obesity-paradox-results-from-the-atahualpa-project
#5
Oscar H Del Brutto, Robertino M Mera
BACKGROUND AND AIMS: The importance of the obesity paradox in the intracranial vasculature has not been explored. We assessed whether the body mass index (BMI) correlates with severity of carotid siphon calcifications (CSC) in community-dwelling adults. METHODS: Using a population-based study design, Atahualpa residents aged ≥40 years underwent head computed tomography (CT) for assessment of CSC. We evaluated the association between BMI and severity of CSC (dependent variable) using regression models adjusted for demographics and cardiovascular risk factors...
February 27, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28268079/gender-disparities-in-the-food-insecurity-overweight-and-food-insecurity-obesity-paradox-among-low-income-older-adults
#6
Daphne C Hernandez, Layton Reesor, Rosenda Murillo
BACKGROUND: Obesity and obesity-related comorbidities are increasing among older adults. Food insecurity is a nutrition-related factor that coexists with obesity among low-income individuals. The majority of the research on the food insecurity-obesity paradox has been conducted on low-income mothers and children, with research lacking on large diverse samples of older adults. OBJECTIVE: The purpose of this study was to assess gender disparities in the association between food insecurity and overweight and obesity among low-income older adults...
March 3, 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28265017/is-there-an-obesity-paradox-for-outcomes-in-atrial-fibrillation-a-systematic-review-and-meta-analysis-of-non-vitamin-k-antagonist-oral-anticoagulant-trials
#7
Marco Proietti, Elisa Guiducci, Paola Cheli, Gregory Y H Lip
BACKGROUND AND PURPOSE: Obesity is a risk factor for all-cause and cardiovascular death but, despite this, an inverse relationship between overweight or obesity and a better cardiovascular prognosis in long-term follow-up studies has been observed; this phenomenon, described as obesity paradox, has also been found evident in atrial fibrillation cohorts. METHODS: We performed a systematic review on the relationship between body mass index and major adverse outcomes in atrial fibrillation patients...
March 6, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28255978/the-effect-of-bmi-serum-leptin-and-adiponectin-levels-on-prognosis-in-patients-with-non-ischaemic-dilated-cardiomyopathy
#8
Celina Wojciechowska, Wojciech Jacheć, Ewa Romuk, Ewa Nowalany-Kozielska, Andrzej Tomasik, Lucyna Siemińska
INTRODUCTION: The recent studies demonstrated that obese heart failure patients have better prognosis - "obesity paradox". The aim of the study was to evaluate the relationship between body mass index (BMI), leptin and adiponectin concentrations and prognosis in patients with heart failure due to non ischeamic dilated cardiomyopathy (NIDCM). MATERIAL AND METHODS: 128 patients with NIDCM were included and followed-up for three years. Leptin and adiponectin were measured at baseline using commercially available ELISA tests...
2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28249867/obesity-paradox-comparison-of-heart-failure-patients-with-and-without-comorbid-diabetes
#9
Kyoung Suk Lee, Debra K Moser, Terry A Lennie, Michele M Pelter, Thomas Nesbitt, Jeffrey A Southard, Kathleen Dracup
BACKGROUND: Diabetes is a common comorbid condition in patients with heart failure and is strongly associated with poor outcomes. Patients with heart failure who have diabetes are more likely to be obese than are those without diabetes. Obesity is positively associated with survival in patients with heart failure, but how comorbid diabetes influences the relationship between obesity and favorable prognosis is unclear. OBJECTIVE: To explore whether the relationship between body mass index and survival differs between patients with heart failure who do or do not have diabetes...
March 2017: American Journal of Critical Care: An Official Publication, American Association of Critical-Care Nurses
https://www.readbyqxmd.com/read/28249273/intestinal-farnesoid-x-receptor-and-takeda-g-protein-couple-receptor-5-signaling-in-metabolic-regulation
#10
John Y L Chiang, Preeti Pathak, Hailiang Liu, Ajay Donepudi, Jessica Ferrell, Shannon Boehme
Bile acids play a critical role in the regulation of glucose, lipid and energy metabolisms by activating the nuclear bile acid receptor farnesoid X receptor (FXR) and membrane G protein-coupled bile acid receptor-1 (aka takeda G protein couple receptor 5, TGR5) signaling. Paradoxical roles of FXR in the regulation of glucose and lipid metabolism and metabolic disorder have been reported recently. The activation or inhibition of intestinal FXR signaling has been shown to improve insulin and glucose sensitivity and energy metabolism to prevent diabetes, obesity and non-alcoholic fatty liver disease (NAFLD)...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/28246337/diacylglycerol-kinase-%C3%AF%C2%B5-deficiency-preserves-glucose-tolerance-and-modulates-lipid-metabolism-in-obese-mice
#11
Louise Mannerås-Holm, Milena Schönke, Joseph T Brozinick, Laurène Vetterli, Hai-Hoang Bui, Philip Sanders, Emmani B M Nascimento, Marie Björnholm, Alexander V Chibalin, Juleen R Zierath
Diacylglycerol kinases (DGKs) catalyze the phosphorylation and conversion of DAG into phosphatidic acid. DGK isozymes have unique primary structures, expression patterns, subcellular localizations, regulatory mechanisms and DAG preferences. DGKε has a hydrophobic segment that promotes its attachment to membranes and shows substrate specificity for DAG with an arachidonoyl acyl chain in the sn-2 position of the substrate. We determined the role of DGKε in the regulation of energy and glucose homeostasis in relation to diet-induced insulin resistance and obesity using DGKε deficient (KO) and wild-type mice...
February 28, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28242638/an-apparent-obesity-paradox-in-cardiac-surgery
#12
EDITORIAL
Mercedes R Carnethon, Sadiya S Khan
No abstract text is available yet for this article.
February 28, 2017: Circulation
https://www.readbyqxmd.com/read/28240939/healthier-than-thou-practicing-what-you-preach-backfires-by-increasing-anticipated-devaluation
#13
Lauren C Howe, Benoît Monin
Should experts always practice what they preach? When an expert displays exemplary behavior, individuals who fear negative devaluation sometimes anticipate that this expert will look down on them. As a result, displays of excellence can paradoxically turn off the very people they are trying to inspire. Five studies document this in the medical domain, showing that individuals who are overweight or obese and concerned about their weight avoid physicians who advertise their fitness, for fear that these doctors will judge them negatively...
February 27, 2017: Journal of Personality and Social Psychology
https://www.readbyqxmd.com/read/28238694/interaction-of-physical-activity-and-body-mass-index-on-mortality-in-coronary-heart-disease-data-from-the-nord-tr%C3%A3-ndelag-health-study
#14
Trine Moholdt, Carl J Lavie, Javaid Nauman
AIMS: The role of physical activity in the BMI-survival relationship in coronary heart disease is unclear. Our aim was to examine isolated and combined associations between BMI and physical activity, and mortality in subjects with coronary heart disease.. METHODS AND RESULTS: 6 493 participants (34.4% women) with coronary heart disease from the Nord-Trøndelag Health Study, with examinations in 1986, 1996, and 2007, were followed until the end of 2014. We calculated hazard ratios (HR) for all-cause and cardiovascular disease mortality, estimated using Cox proportionate hazard regression adjusted for age, smoking, diabetes, hypertension, self-reported health status, and alcohol...
February 23, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28225703/do-acute-hospitalised-patients-in-australia-have-a-different-body-mass-index-to-the-general-australian-population-a-point-prevalence-study
#15
Diane M Dennis, Vicki Carter, Michelle Trevenen, Jacinta Tyler, Luisa Perrella, Erika Lori, Ian Cooper
Objective The aim of the present study was to provide a current snapshot of the body mass index (BMI) of the entire patient cohort of an Australian tertiary hospital on one day and compare these data with current published Australian and state (Western Australia) population norms.Methods A single-centre prospective point prevalence study was performed whereby BMI was calculated following actual measurement of patient weight (nurse) and height (physiotherapist) on one day during 2015. Variables were summarised descriptively, and one-way analysis of variance was used to investigate the relationship between continuous BMI and hospital speciality...
February 23, 2017: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/28219624/the-effects-of-body-mass-index-on-complications-and-mortality-after-emergency-abdominal-operations-the-obesity-paradox
#16
Elizabeth R Benjamin, Evren Dilektasli, Tobias Haltmeier, Elizabeth Beale, Kenji Inaba, Demetrios Demetriades
BACKGROUND: Recent literature suggests that obesity is protective in critically illness. This study addresses the effect of BMI on outcomes after emergency abdominal surgery (EAS). METHODS: Retrospective, ACS-NSQIP analysis. All patients that underwent EAS were included. The study population was divided into five groups based on BMI; regression models were used to evaluate the role of obesity in morbidity and mortality. RESULTS: 101,078 patients underwent EAS; morbidity and mortality were 19...
February 13, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28213000/obesity-is-associated-with-long-term-improved-survival-in-definitively-treated-locally-advanced-non-small-cell-lung-cancer-nsclc
#17
Vincent K Lam, Søren M Bentzen, Pranshu Mohindra, Elizabeth M Nichols, Neha Bhooshan, Melissa Vyfhuis, Katherine A Scilla, Steven J Feigenberg, Martin J Edelman, Josephine L Feliciano
OBJECTIVES: To determine the prognostic effect of Body Mass Index (BMI) in definitively treated locally advanced NSCLC patients. MATERIALS AND METHODS: In this single institution retrospective cohort study, we evaluated 291 patients who were treated for locally advanced NSCLC from 2000 to 2010. They were stratified into four BMI groups based on World Health Organization criteria: underweight (<18.5kg/m2), normal weight (18.5 to <25kg/m2), overweight (25 to <30kg/m2), and obese (≧30kg/m2)...
February 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28209971/obesity-paradox-in-group-1-pulmonary-hypertension-analysis-of-the-nih-pulmonary-hypertension-registry
#18
S Mazimba, E Holland, V Nagarajan, A D Mihalek, J L W Kennedy, K C Bilchick
BACKGROUND: The 'obesity paradox' refers to the fact that obese patients have better outcomes than normal weight patients. This has been observed in multiple cardiovascular conditions, but evidence for obesity paradox in pulmonary hypertension (PH) remains sparse. METHODS: We categorized 267 patients from the NIH PH Registry into five groups based on BMI: underweight, normal weight, overweight, obese, and morbidly obese. Mortality was compared in BMI groups using the chi square statistic...
February 17, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28193372/-scientific-evidence-on-preventive-interventions-in-childhood-obesity
#19
Raquel Alba-Martín
INTRODUCTION: The increasing prevalence of obesity or overweight at all ages, their associated morbidity and mortality associated, and the increased perception of the problem by the society have generated several hypotheses in response to the scientific and the international community. OBJECTIVE: Investigate the preventive interventions in childhood obesity so far. METHODS: Integrative review during the study period from April 2013 to November 2014...
January 2017: Revista Colombiana de Psiquiatría
https://www.readbyqxmd.com/read/28178338/the-impact-of-obesity-and-adiponectin-signaling-in-patients-with-renal-cell-carcinoma-a-potential-mechanism-for-the-obesity-paradox
#20
Ryuichi Ito, Shintaro Narita, Mingguo Huang, Taketoshi Nara, Kazuyuki Numakura, Koichiro Takayama, Hiroshi Tsuruta, Atsushi Maeno, Mitsuru Saito, Takamitsu Inoue, Norihiko Tsuchiya, Shigeru Satoh, Tomonori Habuchi
Although obesity increases the risk of renal cell carcinoma (RCC), obese patients with RCC experience longer survival than non-obese patients. However, the mechanism of this "obesity paradox" is unknown. We examined the impact of preoperative BMI, serum total adiponectin (sAd) level, total adiponectin secretion from perinephric adipose tissue, and intratumoral expression of adiponectin receptors on RCC aggressiveness and survival. We also investigated the mechanism underlying enhanced cancer aggressiveness in RCC cells stimulated with exogenous adiponectin...
2017: PloS One
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