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Exercise AND peripheral vascular disease

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https://www.readbyqxmd.com/read/28527724/review-of-article-leeper-n-j-myers-j-zhou-m-nead-k-t-syed-a-kojima-y-%C3%A2-cooke-j-p-2013-exercise-capacity-is-the-strongest-predictor-of-mortality-in-patients-with-peripheral-arterial-disease-journal-of-vascular-surgery-57-728-33
#1
Rebecca Brown
No abstract text is available yet for this article.
June 2017: Journal of Vascular Nursing: Official Publication of the Society for Peripheral Vascular Nursing
https://www.readbyqxmd.com/read/28498233/wearable-sensor-technology-efficacy-in-peripheral-vascular-disease-wstep-a-randomized-controlled-trial
#2
Pasha Normahani, Richard Kwasnicki, Colin Bicknell, Louise Allen, Mike P Jenkins, Richard Gibbs, Nicholas Cheshire, Ara Darzi, Celia Riga
OBJECTIVE: To evaluate the effect of using wearable activity monitors (WAMs) in patients with intermittent claudication (IC) within a single-center randomized controlled trial. BACKGROUND: WAMs allow users to set daily activity targets and monitor their progress. They may offer an alternative treatment to supervised exercise programs (SEPs) for patients with IC. METHODS: Thirty-seven patients with IC were recruited and randomized into intervention or control group...
May 11, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28492794/exploring-vascular-function-biomarkers-implications-for-rehabilitation
#3
Shane A Phillips, Daniela Kuguimoto Andaku, Renata Gonçalves Mendes, Flávia Rossi Caruso, Ramona Cabiddu, Rodrigo Boemo Jaenisch, Ross Arena, Audrey Borghi-Silva
The endothelium plays an important role in maintaining vascular homeostasis and regulating blood vessel function. Endothelial function is considered an independent predictor for risk of future cardiovascular events in cardiovascular and non-cardiovascular patients, as well as a predictor for postoperative complications in cardiovascular surgery patients. Brachial artery flow-mediated dilation by high-resolution ultrasound is widely used to evaluate endothelium-dependent vasodilation, which is mainly mediated by nitric oxide release...
March 2017: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/28479467/the-natural-history-and-outcomes-of-endovascular-therapy-for-claudication
#4
Julia T Saraidaridis, Emel A Ergul, W Darrin Clouse, Virendra I Patel, Richard P Cambria, Mark F Conrad
INTRODUCTION: The natural history of claudication is well characterized and traditional therapy includes risk factor modification and exercise protocols with revascularization reserved for patients who are severely impaired. However, the reduced peri-procedural morbidity with endovascular therapy has led physicians to broaden the indications for intervention for peripheral artery disease and more claudicants are undergoing procedures for disease that is moderately limiting to their lifestyle...
May 4, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28476756/indie-hfpef-inorganic-nitrite-delivery-to-improve-exercise-capacity-in-heart-failure-with-preserved-ejection-fraction-rationale-and-design
#5
Yogesh N V Reddy, Gregory D Lewis, Sanjiv J Shah, Martin LeWinter, Marc Semigran, Victor G Davila-Roman, Kevin Anstrom, Adrian Hernandez, Eugene Braunwald, Margaret M Redfield, Barry A Borlaug
Approximately half of patients with heart failure have preserved ejection fraction. There is no proven treatment that improves outcome. The pathophysiology of heart failure with preserved ejection fraction is complex and includes left ventricular systolic and diastolic dysfunction, pulmonary vascular disease, endothelial dysfunction, and peripheral abnormalities. Multiple lines of evidence point to impaired nitric oxide (NO)-cGMP bioavailability as playing a central role in each of these abnormalities. In contrast to traditional organic nitrate therapies, an alternative strategy to restore NO-cGMP signaling is via inorganic nitrite...
May 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28463859/adiponectin-lipids-and-atherosclerosis
#6
Niki Katsiki, Christos Mantzoros, Dimitri P Mikhailidis
PURPOSE OF REVIEW: Adiponectin is an adipokine with anti-inflammatory, antioxidant, antiatherogenic, pro-angiogenic, vasoprotective and insulin-sensitizing properties. Several factors may influence adiponectin levels, such as genetic polymorphisms, obesity / body fat distribution, diet and exercise as well as cardiovascular risk factors such as sleep deprivation and smoking as well as medications. Adiponectin has been proposed as a potential prognostic biomarker and a therapeutic target in patients with cardiometabolic diseases...
April 29, 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28410504/exercise-training-in-older-adults-what-effects-on-muscle-oxygenation-a-systematic-review
#7
REVIEW
Elie Fiogbé, Verena de Vassimon-Barroso, Anielle Cristhine de Medeiros Takahashi
AIM: To determine the effects of different modality of exercise training programs on muscle oxygenation in older adults. METHODS: Relevant articles were searched in PubMed, Web of Science, Science Direct and Scopus, using the keywords: "Aged" AND "Muscle oxygenation" AND (Exercise OR "Exercise therapy" OR "Exercise Movement Techniques" OR Hydrotherapy), without limitation concerning the publication date. To be included in the full analysis, the study had to be a randomized controlled trial in which older adults participants (mean age: 65 years at least) were submitted to an exercise-training program and muscle oxygenation assessment...
March 20, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28403379/effect-of-resveratrol-on-walking-performance-in-older-people-with-peripheral-artery-disease-the-restore-randomized-clinical-trial
#8
Mary M McDermott, Christiaan Leeuwenburgh, Jack M Guralnik, Lu Tian, Robert Sufit, Lihui Zhao, Michael H Criqui, Melina R Kibbe, James H Stein, Donald Lloyd-Jones, Stephen D Anton, Tamar S Polonsky, Ying Gao, Rafael de Cabo, Luigi Ferrucci
Importance: Research shows that resveratrol, a sirtuin activator in red wine, improves exercise endurance and skeletal-muscle oxidative metabolism in animals and may enhance vascular function in humans. Resveratrol supplement sales exceed $30 million annually in the United States, but few data are available regarding its efficacy in humans. Objective: To determine whether resveratrol, 125 mg/d or 500 mg/d, improves the 6-minute walk performance in patients with peripheral artery disease (PAD)...
April 12, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28385920/blood-pressure-and-calf-muscle-oxygen-extraction-during-plantar-flexion-exercise-in-peripheral-artery-disease
#9
J Carter Luck, Amanda J Miller, Faisal Aziz, John F Radtka, David N Proctor, Urs A Leuenberger, Lawrence I Sinoway, Matthew D Muller
Peripheral artery disease (PAD) is an atherosclerotic vascular disease that affects 200 million worldwide. While PAD primarily affects large arteries, it is also associated with microvascular dysfunction, an exaggerated blood pressure (BP) response to exercise, and high cardiovascular mortality. We hypothesized that fatiguing plantar flexion exercise that evokes claudication elicits a greater reduction in skeletal muscle oxygenation (SmO2) and a higher rise in BP in PAD compared to age-matched healthy subjects, but low-intensity steady state plantar flexion elicits similar responses between groups...
April 6, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28292763/oxygen-delivery-and-the-restoration-of-the-muscle-energetic-balance-following-exercise-implications-for-delayed-muscle-recovery-in-patients-with-copd
#10
Gwenael Layec, Corey R Hart, Joel D Trinity, Oh-Sung Kwon, Matthew J Rossman, Ryan M Broxterman, Yann Le Fur, Eun-Kee Jeong, Russell S Richardson
Patients with chronic obstructive pulmonary disease (COPD) experience a delayed recovery from skeletal muscle fatigue following exhaustive exercise that likely contributes to their progressive loss of mobility. As this phenomenon is not well understood, this study sought to examine post-exercise peripheral oxygen (O2) transport and muscle metabolism dynamics in patients with COPD, two important determinants of muscle recovery. Twenty four subjects, 12 non-hypoxemic patients with COPD and 12 healthy subjects with a sedentary lifestyle, performed dynamic plantar flexion exercise at 40% of maximal work rate (WRmax) with phosphorus magnetic resonance spectroscopy ((31)P-MRS), near-infrared spectroscopy (NIRS), and vascular Doppler ultrasound assessments...
March 14, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28291304/mitochondrial-dysfunction-in-calf-muscles-of-patients-with-combined-peripheral-arterial-disease-and-diabetes-type-2
#11
Brian Lindegaard Pedersen, Niels Bækgaard, Bjørn Quistorff
BACKGROUND: This study elucidate the effects on muscle mitochondrial function in patients suffering from combined peripheral arterial disease (PAD) and type 2 diabetes (T2D) and the relation to patient symptoms and treatment. METHODS: Near Infra Red Spectroscopy (NIRS) calf muscle exercise tests were conducted on Forty subjects, 15 (PAD), 15 (PAD+T2D) and 10 healthy age matched controls (CTRL) recruited from the vascular outpatient clinic at Gentofte County Hospital, Denmark...
March 14, 2017: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/28255088/oral-n-acetylcysteine-and-exercise-tolerance-in-mild-chronic-obstructive-pulmonary-disease
#12
Daniel M Hirai, Joshua H Jones, Joel T Zelt, Marianne L da Silva, Robert F Bentley, Brittany Ann Edgett, Brendon James Gurd, Michael E Tschakovsky, Denis E O'Donnell, J Alberto Neder
Heightened oxidative stress is implicated in the progressive impairment of skeletal muscle vascular and mitochondrial function in chronic obstructive pulmonary disease (COPD). Whether accumulation of reactive oxygen species contribute to exercise intolerance in the early stages of COPD is unknown. We examined the effects of oral antioxidant treatment with N-acetylcysteine (NAC) on respiratory, cardiovascular and locomotor muscle function and exercise tolerance in patients with mild COPD. Thirteen patients with forced expiratory volume in one second and forced vital capacity ratio (FEV1/FVC) < lower limit of normal (LLN) and FEV1 ≥ LLN were enrolled in a double-blind, randomized crossover study to receive NAC (1800 mg/day) or placebo for 4 days...
March 2, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28241882/systematic-review-of-patient-factors-affecting-adipose-stem-cell-viability-and-function-implications-for-regenerative-therapy
#13
REVIEW
Jajini Varghese, Michelle Griffin, Afshin Mosahebi, Peter Butler
BACKGROUND: The applications for fat grafting have increased recently, within both regenerative and reconstructive surgery. Although fat harvesting, processing and injection techniques have been extensively studied and standardised, this has not had a big impact on the variability of outcome following fat grafting. This suggests a possible larger role of patient characteristics on adipocyte and adipose-derived stem cell (ADSC) viability and function. This systematic review aims to collate current evidence on the effect of patient factors on adipocyte and ADSC behaviour...
February 28, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28225505/nonrevascularizable-buttock-claudication-improved-with-sildenafil-a-case-report
#14
Loukman Omarjee, Audrey Camarzana, Samir Henni, Pierre Abraham
RATIONALE: Sildenafil, a phosphodiesterase-5-inhibitor (PDE5i), could represent a new treatment in addition to the medical treatment and advice to walk in peripheral arterial disease (PAD). PATIENT CONCERNS AND DIAGNOSES: We report a case of a 62-year-old heavy smoker man who developed a buttock claudication and a severe walking limitation following an aorto-bi-femoral bypass in 1992. Since 2003, each year, he has been referred for investigation of bilateral buttock claudication on treadmill using transcutaneous oxygen pressure (tcpO2) measurement during exercise to argue for the vascular origin of the walking impairment...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28155616/crosstalk-between-oxidative-and-nitrosative-stress-and-arterial-stiffness
#15
Ioana Mozos, Constantin Tudor Luca
Arterial stiffness, the expression of reduced arterial elasticity, is an effective predictor of cardiovascular disorders. Oxidative stress is an imbalance between exposure to toxic reactive oxygen species (ROS) and antioxidant systems. The increase in reactive nitrogen species (RNS) is termed nitrosative stress. We review the main mechanisms and products linking arterial stiffness with oxidative and nitrosative stress in several disorders, focusing on recent experimental and clinical data, and the mechanisms explaining benefits of antioxidant therapy...
February 1, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28028947/the-effects-of-controlled-physical-training-on-peripheral-circulation-following-interventional-treatment-of-coronary-artery-disease
#16
Ireneusz Jurczak, Ksenia Jurczak, Robert Irzmański
BACKGROUND: Controlled physical training induces specific changes in the peripheral circulatory system and can lead to positive changes in the vascular perfusion of the lower extremities. OBJECTIVES: The aim of the study was to evaluate changes in peripheral circulation in the calf in patients with acute coronary disease (ACD) undergoing controlled physical training. Impedance plethysmography was used to monitor peripheral circulation during the training. MATERIAL AND METHODS: A total of 90 patients were divided into three study groups...
September 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28002068/an-acute-bout-of-aerobic-exercise-alters-interarm-systolic-blood-pressure-difference
#17
Michael E Holmstrup, Melanie M Clarke, Cailin R Conner, Brock T Jensen
BACKGROUND: Clinically, when a difference of at least 10 mmHg in systolic blood pressure (SBP) between arms exists, it is identified as an interarm systolic blood pressure difference (ISBPD). At rest, ISBPD is linked with hypertension, peripheral vascular disease, and increased premature mortality. Exercise may reveal underlying cardiovascular pathologies otherwise absent at rest. However, there have been no investigations to examine the effect of exercise on ISBPD. AIM: The aim of this investigation was to determine whether exercise may alter ISBPD when detected at rest or reveal ISBPD when it was not observed in the resting condition...
April 2017: Blood Pressure Monitoring
https://www.readbyqxmd.com/read/27997623/the-coupling-of-peripheral-blood-pressure-and-ventilatory-responses-during-exercise-in-young-adults-with-cystic-fibrosis
#18
Erik H Van Iterson, Courtney M Wheatley, Sarah E Baker, Thomas P Olson, Wayne J Morgan, Eric M Snyder
PURPOSE: Cystic fibrosis (CF) is commonly recognized as a pulmonary disease associated with reduced airway function. Another primary symptom of CF is low exercise capacity where ventilation and gas-exchange are exacerbated. However, an independent link between pathophysiology of the pulmonary system and abnormal ventilatory and gas-exchange responses during cardiopulmonary exercise testing (CPET) has not been established in CF. Complicating this understanding, accumulating evidence suggests CF demonstrate abnormal peripheral vascular function; although, the clinical implications are unclear...
2016: PloS One
https://www.readbyqxmd.com/read/27992395/vascular-function-and-structure-in-veteran-athletes-after-myocardial-infarction
#19
Martijn F H Maessen, Thijs M H Eijsvogels, Bregina T P Hijmans-Kersten, Ayla Grotens, Tim H A Schreuder, Maria T E Hopman, Dick H J Thijssen
PURPOSE: Although athletes demonstrate lower cardiovascular risk and superior vascular function compared with sedentary peers, they are not exempted from cardiac events (i.e., myocardial infarction [MI]). The presence of an MI is associated with increased cardiovascular risk and impaired vascular function. We tested the hypothesis that lifelong exercise training in post-MI athletes, similar as in healthy controls, is associated with a superior peripheral vascular function and structure compared with a sedentary lifestyle in post-MI individuals...
January 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27960614/long-term-individual-shear-rate-therapy-counterpulsation-enhances-plasma-nitrite-release-in-patients-with-pad
#20
Michèle Brix, Eva-Elina Buschmann, Andreas Zietzer, Jonnel Anthony Jaurigue, Lulu Li, Constantin Jungk, Ivo Buschmann, Doreen Janke, Philipp Hillmeister
BACKGROUND: Individual shear rate therapy (ISRT) has been designed as a novel non-invasive treatment option for peripheral artery disease (PAD) patients and has been shown to improve endothelial function and walking distance. The aim of this study was to elucidate the impact of ISRT on the level of nitric oxide in patient blood plasma and the expression of related molecular markers in peripheral blood mononuclear cells (PBMCs). Molecular diagnostic tests were performed for two ISRT trials...
January 2017: VASA. Zeitschrift Für Gefässkrankheiten
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