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Exercise AND peripheral vascular disease

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https://www.readbyqxmd.com/read/28028947/the-effects-of-controlled-physical-training-on-peripheral-circulation-following-interventional-treatment-of-coronary-artery-disease
#1
Ireneusz Jurczak, Ksenia Jurczak, Robert Irzmański
BACKGROUND: Controlled physical training induces specific changes in the peripheral circulatory system and can lead to positive changes in the vascular perfusion of the lower extremities. OBJECTIVES: The aim of the study was to evaluate changes in peripheral circulation in the calf in patients with acute coronary disease (ACD) undergoing controlled physical training. Impedance plethysmography was used to monitor peripheral circulation during the training. MATERIAL AND METHODS: A total of 90 patients were divided into three study groups...
September 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28002068/an-acute-bout-of-aerobic-exercise-alters-interarm-systolic-blood-pressure-difference
#2
Michael E Holmstrup, Melanie M Clarke, Cailin R Conner, Brock T Jensen
BACKGROUND: Clinically, when a difference of at least 10 mmHg in systolic blood pressure (SBP) between arms exists, it is identified as an interarm systolic blood pressure difference (ISBPD). At rest, ISBPD is linked with hypertension, peripheral vascular disease, and increased premature mortality. Exercise may reveal underlying cardiovascular pathologies otherwise absent at rest. However, there have been no investigations to examine the effect of exercise on ISBPD. AIM: The aim of this investigation was to determine whether exercise may alter ISBPD when detected at rest or reveal ISBPD when it was not observed in the resting condition...
December 21, 2016: Blood Pressure Monitoring
https://www.readbyqxmd.com/read/27997623/the-coupling-of-peripheral-blood-pressure-and-ventilatory-responses-during-exercise-in-young-adults-with-cystic-fibrosis
#3
Erik H Van Iterson, Courtney M Wheatley, Sarah E Baker, Thomas P Olson, Wayne J Morgan, Eric M Snyder
PURPOSE: Cystic fibrosis (CF) is commonly recognized as a pulmonary disease associated with reduced airway function. Another primary symptom of CF is low exercise capacity where ventilation and gas-exchange are exacerbated. However, an independent link between pathophysiology of the pulmonary system and abnormal ventilatory and gas-exchange responses during cardiopulmonary exercise testing (CPET) has not been established in CF. Complicating this understanding, accumulating evidence suggests CF demonstrate abnormal peripheral vascular function; although, the clinical implications are unclear...
2016: PloS One
https://www.readbyqxmd.com/read/27992395/vascular-function-and-structure-in-veteran-athletes-after-myocardial-infarction
#4
Martijn F H Maessen, Thijs M H Eijsvogels, Bregina T P Hijmans-Kersten, Ayla Grotens, Tim H A Schreuder, Maria T E Hopman, Dick H J Thijssen
PURPOSE: Although athletes demonstrate lower cardiovascular risk and superior vascular function compared with sedentary peers, they are not exempted from cardiac events (i.e., myocardial infarction [MI]). The presence of an MI is associated with increased cardiovascular risk and impaired vascular function. We tested the hypothesis that lifelong exercise training in post-MI athletes, similar as in healthy controls, is associated with a superior peripheral vascular function and structure compared with a sedentary lifestyle in post-MI individuals...
January 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27960614/long-term-individual-shear-rate-therapy-counterpulsation-enhances-plasma-nitrite-release-in-patients-with-pad
#5
Michèle Brix, Eva-Elina Buschmann, Andreas Zietzer, Jonnel Anthony Jaurigue, Lulu Li, Constantin Jungk, Ivo Buschmann, Doreen Janke, Philipp Hillmeister
BACKGROUND: Individual shear rate therapy (ISRT) has been designed as a novel non-invasive treatment option for peripheral artery disease (PAD) patients and has been shown to improve endothelial function and walking distance. The aim of this study was to elucidate the impact of ISRT on the level of nitric oxide in patient blood plasma and the expression of related molecular markers in peripheral blood mononuclear cells (PBMCs). Molecular diagnostic tests were performed for two ISRT trials...
December 14, 2016: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/27940923/prognostic-value-of-an-increase-in-post-exercise-ankle-brachial-index
#6
Tarek A Hammad, William R Hiatt, Heather L Gornik, Mehdi H Shishehbor
Prior studies have assessed the prognostic value of a decrease, not an increase, of the post-exercise ankle-brachial index (ABI) among patients with normal resting results. Thus, we sought to evaluate the prognostic significance of an increase in post-exercise ABI among these patients. From a single center vascular laboratory database between September 2005 and January 2010, we retrospectively identified 1437 consecutive patients with a normal resting ABI (1.00-1.40) and available post-exercise results. We classified them into group 1 (normal subjects; post-exercise ABI drop ⩽ 20%, 58%) and group 2 (post-exercise ABI increase, 42%) after excluding those with an ABI drop > 20% (peripheral artery disease) as they had known disease (n=192)...
December 9, 2016: Vascular Medicine
https://www.readbyqxmd.com/read/27935081/hemodynamic-function-during-finger-force-production-tasks-in-healthy-adults
#7
Luca Pollonini, Lena Younes, Stacey L Gorniak
INTRODUCTION: Near-infrared spectroscopy (NIRS) is a non-invasive technique utilized to measure muscle hemodynamics. The focus of this study was to evaluate changes in muscle oxygenation during sustained maximal force production in young, healthy control individuals to establish baseline function in an ideal population. METHODS: NIRS was used to monitor reduced hemoglobin (HbR) and oxygenated hemoglobin (HbO) in forearm muscles. Hemodynamic responses during force production tasks were monitored in real time...
December 9, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27903484/loss-of-kidney-function-after-endovascular-treatment-of-peripheral-arterial-disease
#8
T A Sigterman, L J J Bolt, A G Krasznai, M G Snoeijs, R Heijboer, G W H Schurink, L H Bouwman
BACKGROUND: Administration of radiocontrast during endovascular procedures for peripheral arterial disease may cause acute kidney injury, which generally recovers with supportive treatment. Long-term effects of endovascular procedures on renal function remain to be investigated. METHOD: This retrospective observational cohort study includes all patients who newly presented to the vascular surgery outpatient clinic with rutherford class II or III peripheral arterial disease and who were treated with either supervised exercise therapy or endovascular interventions...
November 26, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27866570/the-diagnosis-and-treatment-of-peripheral-arterial-vascular-disease
#9
Holger Lawall, Peter Huppert, Christine Espinola-Klein, Gerhard Rümenapf
BACKGROUND: In peripheral arterial occlusive disease (PAOD), arterial stenosis or occlusion impairs perfusion in the territory of the distal portion of the aorta and the iliac and leg arteries. In Germany, the prevalence of PAOD rises with age, reaching 20% among persons over age 70. METHODS: This guideline was prepared by a collaboration of 22 medical specialty societies and two patient self-help organizations on the basis of pertinent publications that were retrieved by a systematic search in PubMed for articles that appeared from 2008 to April 2014, with a subsequent update to May 2015...
October 28, 2016: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/27770498/acute-physical-exercise-and-long-term-individual-shear-rate-therapy-increase-telomerase-activity-in-human-peripheral-blood-mononuclear-cells
#10
A Zietzer, E E Buschmann, D Janke, L Li, M Brix, H Meyborg, P Stawowy, C Jungk, I Buschmann, P Hillmeister
AIM: Physical activity is a potent way to impede vascular ageing. However, patients who suffer from peripheral artery disease (PAD) are often unable to exercise adequately. For those patients, we have developed individual shear rate therapy (ISRT), which is an adaptation of external counterpulsation and enhances endovascular fluid shear stress to increase collateral growth (arteriogenesis). To evaluate the effects of physical exercise and ISRT on the telomere biology of peripheral blood mononuclear cells (PBMCs), we conducted two clinical trials...
October 22, 2016: Acta Physiologica
https://www.readbyqxmd.com/read/27760222/mitochondrial-respiration-after-one-session-of-calf-raise-exercise-in-patients-with-peripheral-vascular-disease-and-healthy-older-adults
#11
Michel van Schaardenburgh, Martin Wohlwend, Øivind Rognmo, Erney J R Mattsson
PURPOSE: Mitochondria are essential for energy production in the muscle cell and for this they are dependent upon a sufficient supply of oxygen by the circulation. Exercise training has shown to be a potent stimulus for physiological adaptations and mitochondria play a central role. Whether changes in mitochondrial respiration are seen after exercise in patients with a reduced circulation is unknown. The aim of the study was to evaluate the time course and whether one session of calf raise exercise stimulates mitochondrial respiration in the calf muscle of patients with peripheral vascular disease...
2016: PloS One
https://www.readbyqxmd.com/read/27753870/poa-02-3-small-vessel-disease-and-hypertension-molecular-mechanisms-and-clinical-implications
#12
Rhian M Touyz
Pathophysiological mechanisms contributing to hypertension include injury to small arteries, characterised by endothelial dysfunction, vascular remodeling, fibrosis and inflammation, (so called hypertensive vascular phenotype). These changes are initially adaptive but in the long term become maladaptive leading to vascular damage and loss of function, particularly important in small resistance arteries, critically involved in the regulation of peripheral vascular resistance and consequently in blood pressure control...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27749546/high-prevalence-of-known-and-unknown-pulmonary-diseases-in-patients-with-claudication-during-exercise-oximetry-a-retrospective-analysis
#13
Christophe Colas-Ribas, Isabelle Signolet, Samir Henni, Mathieu Feuillloy, Frédéric Gagnadoux, Pierre Abraham
The prevalence of pulmonary disease in patients with peripheral artery disease (PAD) has not been extensively studied. Recent evidence has shown that ∼20% of the patients have an atypical chest transcutaneous oxygen pressure (TcpO2) pattern during exercise, which suggests walking-induced hypoxemia. The main objectives of this study were to: (1) describe in a retrospective way the characteristics of the patients suffering from claudication, who attended a treadmill testing in our laboratory, (2) assess the prevalence of known or unknown pulmonary disease...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27702407/-diagnostics-and-treatment-of-lower-extremity-peripheral-arterial-disease-guideline-and-registry
#14
A Vahl, B Elsman, A van Enst
- Revision of the 2005 guideline 'Diagnostics and treatment of lower extremity peripheral arterial disease' and the development of an audit have instigated a degree of efficiency and transparency for the treatment of patients with peripheral arterial disease (PAD). - The key recommendations are that first-line treatment of patients, who - preferably by means of a consultation in a vascular laboratory - are diagnosed with intermittent claudication, is supervised exercise therapy and secondary prevention. Referral for second-line treatment only needs to occur when invasive therapy is considered, for example when there is insufficient improvement in symptoms or in patients who have or are developing critical ischemia...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27694218/exercise-induced-brachial-artery-blood-flow-and-vascular-function-is-impaired-in-systemic-sclerosis
#15
Daniel R Machin, Heather L Clifton, Ryan S Garten, Jayson R Gifford, Russell S Richardson, D Walter Wray, Tracy M Frech, Anthony J Donato
Systemic sclerosis (SSc) is a rare autoimmune disease characterized by debilitating fibrosis and vascular dysfunction; however, little is known about the circulatory response to exercise in this population. Therefore, we examined the peripheral hemodynamic and vasodilatory responses to handgrip exercise in 10 patients with SSc (61 ± 4 yr) and 15 age-matched healthy controls (56 ± 5 yr). Brachial artery diameter, blood flow, and mean arterial pressure (MAP) were determined at rest and during progressive static-intermittent handgrip exercise...
December 1, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27643107/poa-02-3-small-vessel-disease-and-hypertension-molecular-mechanisms-and-clinical-implications
#16
Rhian M Touyz
Pathophysiological mechanisms contributing to hypertension include injury to small arteries, characterised by endothelial dysfunction, vascular remodeling, fibrosis and inflammation, (so called hypertensive vascular phenotype). These changes are initially adaptive but in the long term become maladaptive leading to vascular damage and loss of function, particularly important in small resistance arteries, critically involved in the regulation of peripheral vascular resistance and consequently in blood pressure control...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27620999/revascularization-and-muscle-adaptation-to-limb-demand-ischemia-in-diet-induced-obese-mice
#17
Hassan Albadawi, A Aria Tzika, Christian Rask-Madsen, Lindsey M Crowley, Michael W Koulopoulos, Hyung-Jin Yoo, Michael T Watkins
BACKGROUND: Obesity and type 2 diabetes are major risk factors for peripheral arterial disease in humans, which can result in lower limb demand ischemia and exercise intolerance. Exercise triggers skeletal muscle adaptation including increased vasculogenesis. The goal of this study was to determine whether demand ischemia modulates revascularization, fiber size, and signaling pathways in the ischemic hind limb muscles of mice with diet-induced obesity (DIO). MATERIALS AND METHODS: DIO mice (n = 7) underwent unilateral femoral artery ligation and recovered for 2 wks followed by 4 wks with daily treadmill exercise to induce demand ischemia...
September 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27603342/exercise-transcutaneous-oxygen-pressure-measurement-has-good-sensitivity-and-specificity-to-detect-lower-extremity-arterial-stenosis-assessed-by-computed-tomography-angiography
#18
Caroline Koch, Emmanuel Chauve, Ségolène Chaudru, Alexis Le Faucheur, Vincent Jaquinandi, Guillaume Mahé
Peripheral artery disease (PAD) is a highly prevalent disease diagnosed by the use of ankle-brachial index (ABI) at rest. In some clinical conditions (diabetes, renal insufficiency, advanced age), ABI can be falsely normal and other tests are required for the PAD diagnosis (American Heart Association statement). This study was conducted to determine the accuracy of exercise transcutaneous oxygen pressure measurement (exercise-TcPo2) in detection of arterial stenosis ≥50% using computed tomography angiography (CTA) as the gold standard...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27575303/coronary-exercise-hyperemia-is-impaired-in-patients-with-peripheral-arterial-disease
#19
Amanda J Ross, Zhaohui Gao, Jonathan Carter Luck, Cheryl A Blaha, Aimee E Cauffman, Faisal Aziz, John F Radtka, David N Proctor, Urs A Leuenberger, Lawrence I Sinoway, Matthew D Muller
BACKGROUND: Peripheral arterial disease (PAD) is an atherosclerotic vascular disease that affects over 200 million people worldwide. The hallmark of PAD is ischemic leg pain and this condition is also associated with an augmented blood pressure response to exercise, impaired vascular function, and high risk of myocardial infarction and cardiovascular mortality. In this study, we tested the hypothesis that coronary exercise hyperemia is impaired in PAD. METHODS: Twelve patients with PAD and no overt coronary disease (65 ± 2 years, 7 men) and 15 healthy control subjects (64 ± 2 years, 9 men) performed supine plantar flexion exercise (30 contractions/min, increasing workload)...
January 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27550906/supervised-exercise-training-in-peripheral-arterial-disease-increases-vascular-shear-stress-and-profunda-femoral-artery-diameter
#20
Jörn F Dopheide, Jennifer Rubrech, Amelie Trumpp, Philipp Geissler, Geraldine C Zeller, Boris Schnorbus, Frank Schmidt, Tommaso Gori, Thomas Münzel, Christine Espinola-Klein
Background Arteriogenesis is promoted by flow- and pressure-related forces such as tangential wall stress and laminar shear stress. Exercise training (ET) is known to promote arteriogenesis in peripheral arterial disease (PAD) patients. It remains unclear whether supervised ET (SET) promotes arteriogenesis more efficiently than non-SET (nSET). Methods and results Forty PAD patients participated in a SET or nSET training programme ( n = 20 each) and were compared to 20 healthy individuals without any history of cardiovascular events...
January 2017: European Journal of Preventive Cardiology
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