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Exercise AND heart failure

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https://www.readbyqxmd.com/read/28925093/limited-contractile-reserve-contributes-to-poor-peak-exercise-capacity-in-iron-deficient-heart-failure
#1
Pieter Martens, Frederik H Verbrugge, Petra Nijst, Matthias Dupont, Wilfried Mullens
No abstract text is available yet for this article.
September 18, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28925073/role-of-cardiopulmonary-exercise-testing-in-clinical-stratification-in-heart-failure-a-position-paper-from-the-committee-on-exercise-physiology-and-training-of-the-heart-failure-association-of-the-european-society-of-cardiology
#2
REVIEW
Ugo Corrà, Pier Giuseppe Agostoni, Stefan D Anker, Andrew J S Coats, Maria G Crespo Leiro, Rudolph A de Boer, Veli-Pekka Hairola, Loreena Hill, Mitja Lainscak, Lars H Lund, Marco Metra, Piotr Ponikowski, Jillian Riley, Petar M Seferović, Massimo F Piepoli
Traditionally, the main indication for cardiopulmonary exercise testing (CPET) in heart failure (HF) was for the selection of candidates to heart transplantation: CPET was mainly performed in middle-aged male patients with HF and reduced left ventricular ejection fraction. Today, CPET is used in broader patients' populations, including women, elderly, patients with co-morbidities, those with preserved ejection fraction, or left ventricular assistance device recipients, i.e. individuals with different responses to incremental exercise and markedly different prognosis...
September 18, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28924977/performing-lung-ultrasound-at-rest-and-or-after-an-exercise-stress-test-to-better-identify-high-risk-ambulatory-patients-with-heart-failure
#3
EDITORIAL
Nicolas Girerd, Patrick Rossignol
No abstract text is available yet for this article.
September 18, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28919241/cardiopulmonary-exercise-testing-in-patients-with-heart-failure-and-a-preserved-ejection-fraction-filling-the-prognostic-knowledge-gap
#4
Cemal Ozemek, Ross Arena
No abstract text is available yet for this article.
September 14, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28918895/a-method-for-determining-exercise-oscillatory-ventilation-in-heart-failure-prognostic-value-and-practical-implications
#5
Baruch Vainshelboim, Aisha Amin, Jeffrey W Christle, Shreyas Hebbal, Euan A Ashley, Jonathan Myers
BACKGROUND: Exercise oscillatory ventilation (EOV) has been shown to be a powerful prognostic marker in chronic heart failure (CHF). However, EOV is poorly defined, its measurement lacks standardization and it is underutilized in clinical practice. The purpose of this pilot study was to investigate the prognostic value of a modified definition of EOV in patients with CHF. METHODS: Eighty-nine CHF patients (56.5±8.4years) (64% NYHA class III-IV) underwent cardiopulmonary exercise testing...
September 14, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28916479/dietary-nitrate-increases-vo2peak-and-performance-but-does-not-alter-ventilation-or-efficiency-in-patients-with-heart-failure-with-reduced-ejection-fraction
#6
Andrew R Coggan, Seth R Broadstreet, Kiran Mahmood, Deana Mikhalkova, Michael Madigan, Indra Bole, Soo Park, Joshua L Leibowitz, Ana Kadkhodayan, Deepak P Thomas, Dakkota Thies, Linda R Peterson
BACKGROUND: Patients with heart failure with reduced ejection fraction (HFrEF) exhibit lower efficiency, dyspnea, and diminished peak O2 uptake (VO2peak) during exercise. Dietary nitrate (NO3(-)), a source of nitric oxide (NO), has improved these measures in some studies of other populations. We determined the effects of acute NO3(-) ingestion on exercise responses in eight patients with HFrEF using a randomized, double-blind, placebo-controlled, crossover design. METHODS AND RESULTS: Plasma NO3(-), nitrite (NO2(-)), and breath NO were measured at multiple time points and respiratory gas exchange was determined during exercise after ingestion of beetroot juice containing or devoid of 11...
September 12, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28912263/hemodynamic-phenotyping-of-pulmonary-hypertension-in-left-heart-failure
#7
REVIEW
Robert Naeije, Mario Gerges, Jean-Luc Vachiery, Sergio Caravita, Christian Gerges, Irene M Lang
Increased pulmonary venous pressure secondary to left heart disease is the most common cause of pulmonary hypertension (PH). The diagnosis of PH due to left heart disease relies on a clinical probability assessment followed by the invasive measurements of a mean pulmonary artery pressure (PAP) ≥25 mm Hg and mean wedged PAP (PAWP) >15 mm Hg. A combination of mean PAP and mean PAWP defines postcapillary PH. Postcapillary PH is generally associated with a diastolic pulmonary pressure gradient (diastolic PAP minus mean PAWP) <7 mm Hg, a transpulmonary pressure gradient (mean PAP minus mean PAWP) <12 mm Hg, and pulmonary vascular resistance ≤3 Wood units (WU)...
September 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28911236/comments-on-effects-of-yoga-versus-hydrotherapy-training-on-health-related-quality-of-life-and-exercise-capacity-in-patients-with-heart-failure-a-randomized-controlled-study
#8
Sergio Rico-Martín, Esperanza Santano-Mogena, José L Cobos-Serrano, Julián F Calderón-García
No abstract text is available yet for this article.
September 1, 2017: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/28905503/the-complex-interplay-between-systolic-and-diastolic-function-at-rest-and-during-exercise-in-heart-failure-the-case-of-cardiac-amyloidosis
#9
EDITORIAL
Claudio Rapezzi, Agnese Milandri, Massimiliano Lorenzini
No abstract text is available yet for this article.
September 14, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28902683/exercise-oscillatory-ventilation-inter-reviewer-agreement-and-a-novel-determination
#10
Clinton A Brawner, Jonathan K Ehrman, Jonathan Myers, Paul Chase, Baruch Vainshelboim, Shadi Farha, Matthew A Saval, Rita McGuire, Bunny Pozehl, Steven J Keteyian
INTRODUCTION: Determination of exercise oscillatory ventilation (EOV) is subjective and the inter-reviewer agreement has not been reported. The purpose of this study was, among patients with heart failure (HF): (1) determine the inter-reviewer agreement for EOV; and (2) describe a novel, objective, and quantifiable measure of EOV. METHODS: This was a secondary analysis of the HEART Camp: Promoting Adherence to Exercise in Patients with Heart Failure study. EOV was determined through a blinded review by 6 individuals based on their interpretation of the EOV literature...
September 11, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28887766/short-term-effects-of-passive-mobilization-on-the-sublingual-microcirculation-and-on-the-systemic-circulation-in-patients-with-septic-shock
#11
Tuanny Teixeira Pinheiro, Flávio Geraldo Rezende de Freitas, Karla Tuanny Fiorese Coimbra, Vanessa Marques Ferreira Mendez, Heloísa Baccaro Rossetti, Paulo Vinicius Talma, Antônio Tonete Bafi, Flávia Ribeiro Machado
BACKGROUND: Active mobilization is not possible in patients under deep sedation and unable to follow commands. In this scenario, passive therapy is an interesting alternative. However, in patients with septic shock, passive mobilization may have risks related to increased oxygen consumption. Our objective was to evaluate the impact of passive mobilization on sublingual microcirculation and systemic hemodynamics in patients with septic shock. METHODS: We included patients who were older than 18 years, who presented with septic shock, and who were under sedation and mechanical ventilation...
September 8, 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28883851/improvement-of-exercise-tolerance-in-cardiopulmonary-testing-with-sustained-safety-after-regular-training-in-outpatients-with-systolic-heart-failure-nyha-iii-and-an-implantable-cardioverter-defibrillator-prospective-18-month-randomized-study
#12
Edyta Smolis-Bąk, Hanna Rymuza, Barbara Kazimierska, Ilona Kowalik, Tomasz Chwyczko, Anna Borowiec, Witold Rongies, Agnieszka Jankowska, Hanna Szwed, Rafał Dąbrowski
INTRODUCTION: The aim of the study was to evaluate the impact of individual training on the level of physical capacity and echocardiographic parameters in patients with systolic heart failure (SHF), NYHA III and an implantable cardioverter-defibrillator (ICD). MATERIAL AND METHODS: The study included 84 patients with SHF, randomly assigned to one of two groups: with regular training (ICD-Ex) and a control group (ICD-control). The ICD-Ex group participated in a hospital rehabilitation program which after discharge was individually continued for 6 months in an outpatient setting...
August 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28883713/patients-knowledge-of-heart-failure-and-their-perception-of-the-disease
#13
Anna Płotka, Edyta Prokop, Jacek Migaj, Ewa Straburzyńska-Migaj, Stefan Grajek
PURPOSE: The aim of this study was to gain a deeper insight into patients' perception of chronic heart failure (CHF) symptoms by analyzing their compliance with nonpharmacological recommendations. PATIENTS AND METHODS: This was a prospective, single-center survey-based registry. Patients included in this study were hospitalized between December 2014 and January 2016 at the 1(st) Department of Cardiology, University Hospital of Lord's Transfiguration, Poznań University of Medical Sciences, and had been diagnosed with CHF at least 3 months prior to inclusion...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28883044/beneficial-effects-of-exercise-training-in-heart-failure-are-lost-in-male-diabetic-rats
#14
Dalila Boudia, Valérie Domergue, Phlippe Mateo, Loubina Fazal, Mathilde Prud'homme, Heloise Prigent, Claude Delcayre, Alain Cohen-Solal, Anne Garnier, Renee Ventura-Clapier, Jane-Lise Samuel
Exercise training has been demonstrated to have beneficial effects in patients with heart failure (HF) or diabetes. However, it is unknown whether diabetic patients with HF will benefit from exercise training. Male Wistar rats were fed either a standard (Sham, n= 53) or high-fat, high-sucrose (HFHS) diet (D, n=66) for 6 months. After 2 months of diet, the rats were already diabetic. Rats were then randomly subjected to either myocardial infarction by coronary artery ligation (MI) or sham operation (Sham). Two months later, heart failure was documented by echocardiography and animals were randomly subjected to exercise training with treadmill for eight additional weeks or remained sedentary...
September 7, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28880460/cryopreserved-off-the-shelf-allogeneic-adipose-derived-stromal-cells-for-therapy-in-patients-with-ischemic-heart-disease-and-heart-failure-a-safety-study
#15
Jens Kastrup, Mandana Haack-Sørensen, Morten Juhl, Rebekka Harary Søndergaard, Bjarke Follin, Lisbeth Drozd Lund, Ellen Mønsted Johansen, Abbas Ali Qayyum, Anders Bruun Mathiasen, Erik Jørgensen, Steffen Helqvist, Jens Jørgen Elberg, Helle Bruunsgaard, Annette Ekblond
The present first-in-human clinical trial evaluated the safety and feasibility of a newly developed and cryopreserved Cardiology Stem Cell Centre adipose-derived stromal cell (CSCC_ASC) product from healthy donors for intramyocardial injection in ten patients with ischemic heart disease and ischemic heart failure (IHF). Batches of CSCC_ASC were isolated from three healthy donors by liposuction from abdominal adipose tissue. Adipose mesenchymal stromal cells were culture expanded in bioreactors without the use of animal constituents, cryopreserved, and stored in vials in nitrogen dry-storage containers until use...
September 7, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28879684/epigenetic-regulation-of-sirt1-induced-skeletal-muscle-mass-exercise-and-heart-diseases
#16
Tiago Fernandes, João Lucas P Gomes, André C Silveira
Skeletal myopathy is commonly recognized as a major cause of exercise intolerance in cardiac diseases such as chronic heart failure; which contributes to increased morbidity and mortality. This article is protected by copyright. All rights reserved.
September 6, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28878952/pathophysiology-of-exercise-intolerance-in-chronic-diseases-the-role-of-diminished-cardiac-performance-in-mitochondrial-and-heart-failure-patients
#17
Jodi McCoy, Matthew Bates, Christopher Eggett, Mario Siervo, Sophie Cassidy, Jane Newman, Sarah A Moore, Grainne Gorman, Michael I Trenell, Lazar Velicki, Petar M Seferovic, John G F Cleland, Guy A MacGowan, Doug M Turnbull, Djordje G Jakovljevic
OBJECTIVE: Exercise intolerance is a clinical hallmark of chronic conditions. The present study determined pathophysiological mechanisms of exercise intolerance in cardiovascular, neuromuscular, and metabolic disorders. METHODS: In a prospective cross-sectional observational study 152 patients (heart failure reduced ejection fraction, n=32; stroke, n=34; mitochondrial disease, n=28; type two diabetes, n=28; and healthy controls, n=30) performed cardiopulmonary exercise testing with metabolic and haemodynamic measurements...
2017: Open Heart
https://www.readbyqxmd.com/read/28875043/the-role-of-endoplasmic-reticulum-stress-in-cardiovascular-disease-and-exercise
#18
REVIEW
Junyoung Hong, Kwangchan Kim, Jong-Hee Kim, Yoonjung Park
Endoplasmic reticulum (ER) stress, which is highly associated with cardiovascular disease, is triggered by a disturbance in ER function because of protein misfolding or an increase in protein secretion. Prolonged disruption of ER causes ER stress and activation of the unfolded protein response (UPR) and leads to various diseases. Eukaryotic cells respond to ER stress via three major sensors that are bound to the ER membrane: activating transcription factor 6 (ATF6), inositol-requiring protein 1α (IRE1α), and protein kinase RNA-like ER kinase (PERK)...
2017: International Journal of Vascular Medicine
https://www.readbyqxmd.com/read/28871621/systolic-blood-pressure-reduction-during-the-first-24%C3%A2-h-in-acute-heart-failure-admission-friend-or-foe
#19
Gad Cotter, Marco Metra, Beth A Davison, Guillaume Jondeau, John G F Cleland, Robert C Bourge, Olga Milo, Christopher M O'Connor, John D Parker, Guillermo Torre-Amione, Dirk J van Veldhuisen, Isaac Kobrin, Maurizio Rainisio, Stefanie Senger, Christopher Edwards, John J V McMurray, John R Teerlink
AIMS: Changes in systolic blood pressure (SBP) during an admission for acute heart failure (AHF), especially those leading to hypotension, have been suggested to increase the risk for adverse outcomes. METHODS AND RESULTS: We analysed associations of SBP decrease during the first 24 h from randomization with serum creatinine changes at the last time-point available (72 h), using linear regression, and with 30- and 180-day outcomes, using Cox regression, in 1257 patients in the VERITAS study...
September 4, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28870770/mechanisms-of-the-improvement-in-peak-vo2-with-exercise-training-in-heart-failure-with-reduced-or-preserved-ejection-fraction
#20
REVIEW
Wesley J Tucker, Cecilia C Lijauco, Christopher M Hearon, Siddhartha S Angadi, Michael D Nelson, Satyam Sarma, Shane Nanayakkara, André La Gerche, Mark J Haykowsky
Heart failure (HF) is a major health care burden associated with high morbidity and mortality. Approximately 50% of HF patients have reduced ejection fraction (HFrEF) while the remainder of patients have preserved ejection fraction (HFpEF). A hallmark of both HF phenotypes is dyspnoea upon exertion and severe exercise intolerance secondary to impaired oxygen delivery and/or use by exercising skeletal muscle. Exercise training is a safe and effective intervention to improve peak oxygen uptake (VO2peak) and quality of life in clinically stable HF patients, however, evidence to date suggests that the mechanism of this improvement appears to be related to underlying HF phenotype...
August 4, 2017: Heart, Lung & Circulation
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