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Exercise AND heart failure

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https://www.readbyqxmd.com/read/27909753/six-minute-walk-test-as-a-predictor-for-outcome-in-children-with-dilated-cardiomyopathy-and-chronic-stable-heart-failure
#1
Susanna L den Boer, Daniël H K Flipse, Marijke H van der Meulen, Ad P C M Backx, Gideon J du Marchie Sarvaas, Arend D J Ten Harkel, Gabriëlle G van Iperen, Lukas A J Rammeloo, Ronald B Tanke, Willem A Helbing, Tim Takken, Michiel Dalinghaus
Cardiopulmonary exercise testing is an important tool to predict prognosis in children and adults with heart failure. A much less sophisticated exercise test is the 6 min walk test, which has been shown an independent predictor for morbidity and mortality in adults with heart failure. Therefore, we hypothesized that the 6 min walk test could be predictive for outcome in children with dilated cardiomyopathy. We prospectively included 49 children with dilated cardiomyopathy ≥6 years who performed a 6 min walk test...
December 1, 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/27909230/the-protective-role-of-sex-hormones-in-females-and-exercise-prehabilitation-in-males-on-sternotomy-induced-cranial-hypoperfusion-in-aortic-banded-mini-swine
#2
T Dylan Olver, Jessica A Hiemstra, Jenna C Edwards, Brian S Ferguson, Harold Laughlin, Craig A Emter
During cardiac surgery, specifically sternotomy, cranial hypoperfusion is linked to cerebral ischemia, increased risk of perioperative watershed stroke and other neurocognitive complications. The purpose of this study was to retrospectively examine the effect of sex hormones in females and exercise prehabilitation in males on median sternotomy-induced changes in cranial perfusion in a large animal model of heart failure. Cranial blood flow (CBF) before, 10- and 60 min post-sternotomy was analyzed in eight groups of Yucatan mini-swine: female-control, aortic-banded, ovariectomized, and ovariectomized+aortic-banded; male-control, aortic-banded, aortic-banded+continuous exercise trained, and aortic-banded+interval exercise trained...
December 1, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27905297/altered-thermoregulatory-responses-in-heart-failure-patients-exercising-in-the-heat
#3
Bryce N Balmain, Ollie Jay, Surendran Sabapathy, Danielle Royston, Glenn M Stewart, Rohan Jayasinghe, Norman R Morris
Heart failure (HF) patients appear to exhibit impaired thermoregulatory capacity during passive heating, as evidenced by diminished vascular conductance. Although some preliminary studies have described the thermoregulatory response to passive heating in HF, responses during exercise in the heat remain to be described. Therefore, the aim of this study was to compare thermoregulatory responses in HF and controls (CON) during exercise in the heat. Ten HF (NYHA classes I-II) and eight CON were included. Core temperature (Tc), skin temperature (Tsk), and cutaneous vascular conductance (CVC) were assessed at rest and during 1 h of exercise at 60% of maximal oxygen uptake...
November 2016: Physiological Reports
https://www.readbyqxmd.com/read/27898735/cognitive-dysfunction-and-malnutrition-are-independent-predictor-of-dysphagia-in-patients-with-acute-exacerbation-of-congestive-heart-failure
#4
Junichi Yokota, Yoshiko Ogawa, Shinsuke Yamanaka, Yoshimi Takahashi, Hiroshi Fujita, Nobuhiro Yamaguchi, Noriko Onoue, Takeshi Ishizuka, Tsuyoshi Shinozaki, Masahiro Kohzuki
Early detection and intervention for dysphagia is important in patients with congestive heart failure (CHF). However, previous studies have focused on how many patients with dysphagia develop CHF. Studies focusing on the comorbidity of dysphagia in patients with CHF are rare. Additionally, risk factors for dysphagia in patients with CHF are unclear. Thus, the aim of this study was to clarify risk factors for dysphagia in patients with acute exacerbation of CHF. A total of 105 patients, who were admitted with acute exacerbation of CHF, were enrolled...
2016: PloS One
https://www.readbyqxmd.com/read/27895476/community-based-exercise-training-for-people-with-chronic-respiratory-and-chronic-cardiac-disease-a-mixed-methods-evaluation
#5
Renae J McNamara, Zoe J McKeough, Laura R Mo, Jamie T Dallimore, Sarah M Dennis
BACKGROUND: Poor uptake and adherence are problematic for hospital-based pulmonary and heart failure rehabilitation programs, often because of access difficulties. The aims of this mixed-methods study were to determine the feasibility of a supervised exercise training program in a community gymnasium in people with chronic respiratory and chronic cardiac disease, to explore the experiences of participants and physiotherapists and to determine if a community venue improved access and adherence to rehabilitation...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27895211/improvement-in-aerobic-capacity-during-cardiac-rehabilitation-in-coronary-artery-disease-patients-is-there-a-role-for-autonomic-adaptations
#6
Davide Lazzeroni, Paolo Castiglioni, Matteo Bini, Andrea Faini, Umberto Camaiora, Pietro Tito Ugolotti, Claudio Stefano Centorbi, Lorenzo Brambilla, Valerio Brambilla, Massimo Francesco Piepoli, Paolo Coruzzi
BACKGROUND: It has been previously shown in patients with heart failure that exercise-based rehabilitation programmes may improve functional capacity and autonomic response. The aim of this study was to investigate this issue further by evaluating whether an association exists between autonomic adaptations and improvements of aerobic capacity in a general population of coronary artery disease patients undergoing cardiac rehabilitation. METHODS: Ninety consecutive patients (age 60 ± 11 years) attended a rehabilitation programme of moderate continuous training (25 ± 8 sessions, 2-3 sessions/week)...
November 28, 2016: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/27892422/prognostic-value-of-serial-six-minute-walk-tests-using-tele-accelerometry-in-patients-with-chronic-heart-failure-a-pre-specified-sub-study-of-the-tim-hf-trial
#7
Sandra Prescher, Christoph Schoebel, Kerstin Koehler, Oliver Deckwart, Brunhilde Wellge, Marcus Honold, Oliver Hartmann, Sebastian Winkler, Friedrich Koehler
BACKGROUND: The six-minute walk test (6MWT) is an established functional test assessing exercise capacity and is used to predict clinical prognosis in patients with chronic heart failure (HF). Tele-accelerometry is a novel approach to activity monitoring using telemedical data transfer and allows a Tele-6MWT to be performed in an outpatient setting. It offers patients the option of performing simple serial follow-up tests in their own home. AIMS: The aim of this study was to investigate the prognostic value of serial Tele-6MWTs using tele-accelerometry in patients with HF...
October 2016: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/27887692/mechanisms-of-effort-intolerance-in-patients-with-heart-failure-and-borderline-ejection-fraction
#8
Yan Topilsky, Zach Rozenbaum, Shafik Khoury, Gregg S Pressman, Yaniv Gura, Jack Sherez, Avi Man, Jason Shimiaie, Sanford Edwards, Joshua Berookhim, Thierry Le Tourneau, Amir Halkin, Simon Biner, Gad Keren, Galit Aviram
Combining echocardiography and cardiopulmonary stress testing allows noninvasive assessment of hemodynamics, and oxygen extraction (A-VO2 difference). We evaluated mechanisms of effort intolerance in patients with heart failure with borderline (40% to 49%) left ventricular ejection fraction (EF) (HF and Borderline Ejection fraction). We included 89 consecutive patients with HF and Borderline Ejection fraction (n = 25; 63.6 ± 14 years, 64% men), control subjects (n = 22), patients with HF with preserved EF (n = 26; EF ≥50%), and patients with HF with reduced EF (n = 16; <40%)...
November 1, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27884004/precapillary-pulmonary-hypertension-and-sleep-disordered-breathing-is-there-a-link
#9
Robert Thurnheer, Silvia Ulrich, Konrad E Bloch
Among patients with sleep apnea the reported prevalence of precapillary pulmonary hypertension (PH) has varied largely, depending on patient selection, disease definition, and associated conditions, in particular chronic pulmonary disease. However, in the absence of comorbidities, PH seems to be rare in patients with sleep apnea. Conversely, sleep-related breathing disorders have been commonly found in patients with PH and they have been associated with an impaired quality of life. Since sleep-related breathing disorders may affect the pulmonary circulation and vice versa, patients with sleep-related breathing disorders should be evaluated for risk factors, symptoms and clinical signs of PH and right ventricular heart failure and patients with PH should be evaluated for sleep apnea...
November 25, 2016: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/27881506/development-and-evolution-of-a-hierarchical-clinical-composite-end-point-for-the-evaluation-of-drugs-and-devices-for-acute-and-chronic-heart-failure-a-20-year-perspective
#10
Milton Packer
Traditional approaches to the assessment of new treatments for heart failure have generally evaluated individual components of the syndrome at fixed points in time or have relied on surrogate physiological measures that are poorly correlated with the clinical status of patients. Conventional time-to-event trials that focus on morbidity and mortality represent an important methodological advance, but they generally assign undue weight to clinical events of less importance and are insensitive to difference in functional capacity among individuals who do not experience a clinical event during follow-up...
November 22, 2016: Circulation
https://www.readbyqxmd.com/read/27878925/left-ventricular-deformation-at-rest-predicts-exercise-induced-elevation-in-pulmonary-artery-wedge-pressure-in-patients-with-unexplained-dyspnoea
#11
Tor Biering-Sørensen, Mário Santos, Jose Rivero, Shane D McCullough, Erin West, Alexander R Opotowsky, Aaron B Waxman, David M Systrom, Amil M Shah
AIMS: Impaired left ventricular (LV) deformation despite preserved LV ejection fraction (LVEF) is common and predicts outcomes in heart failure with preserved LVEF. We hypothesized that impaired LV deformation at rest is a marker of impaired cardiac systolic and diastolic reserve, and aimed to determine whether resting longitudinal (LS) and circumferential strain (CS) are associated with invasively measured haemodynamic response to exercise in patients with dyspnoea and a normal LVEF...
November 22, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27875738/heart-rate-response-to-exercise-in-heart-failure-patients-the-prognostic-role-of-metabolic-chronotropic-relation-and-heart-rate-recovery
#12
Pavel Hajdusek, Martin Kotrc, Josef Kautzner, Vojtech Melenovsky, Eva Benesova, Petr Jarolim, Jan Benes
BACKGROUND: The dynamics of the sinus node response to exercise is linked to functional capacity and outcome in heart failure (HF). The goal of the work was to analyze determinants and impacts of cardio-acceleration, described by the concept of metabolic-chronotropic relation (MCR) and of cardio-deceleration, described by heart rate recovery (HRR). METHODS: A cohort of 25 healthy controls and 78 patients with advanced systolic HF and optimized medical and/or device therapy (97% receiving beta-blockers, 54% ICD) underwent maximal cardiopulmonary exercise test and were prospectively followed...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27873388/effects-of-sildenafil-on-cardiac-structure-and-function-cardiopulmonary-exercise-testing-and-health-related-quality-of-life-measures-in-heart-failure-patients-with-preserved-ejection-fraction-and-pulmonary-hypertension
#13
Licette C Y Liu, Yoran M Hummel, Peter van der Meer, Rolf M F Berger, Kevin Damman, Dirk J van Veldhuisen, Adriaan A Voors, Elke S Hoendermis
AIMS: We recently showed that sildenafil did not improve pulmonary pressures and exercise capacity in a cohort of patients with heart failure and preserved ejection fraction (HFpEF) and predominantly postcapillary pulmonary hypertension. Here, we present the effects of sildenafil on cardiac structure and function, cardiopulmonary exercise testing, laboratory parameters and health-related quality of life measures. METHODS AND RESULTS: Fifty-two HFpEF patients with pulmonary hypertension (mean pulmonary artery pressure >25 mmHg; pulmonary artery wedge pressure >15 mmHg) were randomized to sildenafil 60 mg three times a day or placebo and treated for 12 weeks...
November 21, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27871197/left-ventricular-assist-device-induced-reverse-remodeling-it-s-not-just-about-myocardial-recovery
#14
Karolina K Marinescu, Nir Uriel, Douglas L Mann, Daniel Burkhoff
The abnormal structure, function and molecular makeup of dilated cardiomyopathic hearts can be partially normalized in patients supported by a left ventricular assist device (LVAD), a process called reverse remodeling. This leads to recovery of function in many patients, though the rate of full recovery is low and in many cases is temporary, leading to the concept of heart failure remission, rather than recovery. Areas covered: We summarize data indicative of ventricular reverse remodeling, recovery and remission during LVAD support...
November 22, 2016: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/27867115/central-chemoreceptor-sensitivity-is-not-enhanced-in-contemporary-patients-with-chronic-systolic-heart-failure-receiving-optimal-treatment
#15
Bartłomiej Paleczny, Martyna Olesińska, Agnieszka Siennicka, Piotr Niewiński, Ewa A Jankowska, Beata Ponikowska, W Banasiak, Stephan von Haehling, Stefan D Anker, Piotr Ponikowski
BACKGROUND: Clinical and prognostic consequences of enhanced central chemosensitivity in the contemporary optimally treated patients with chronic heart failure (CHF) are unknown. METHODS AND RESULTS: We studied central chemosensitivity (defined as the ventilatory response to hypercapnia assessed by the rebreathing method, HCVR [L/min/mmHg]) in 161 CHF patients (mean left ventricular ejection fraction [LVEF]: 31±6%, all receiving a combination of angiotensin-converting enzyme inhibitor/angiotensin receptor blocker and beta-blocker) and 55 sex-, age-matched healthy controls...
November 17, 2016: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/27864509/loss-of-%C3%AE-adrenergic-stimulated-phosphorylation-of-cav1-2-channels-on-ser1700-leads-to-heart-failure
#16
Linghai Yang, Dao-Fu Dai, Can Yuan, Ruth E Westenbroek, Haijie Yu, Nastassya West, Horacio O de la Iglesia, William A Catterall
L-type Ca(2+) currents conducted by voltage-gated calcium channel 1.2 (CaV1.2) initiate excitation-contraction coupling in the heart, and altered expression of CaV1.2 causes heart failure in mice. Here we show unexpectedly that reducing β-adrenergic regulation of CaV1.2 channels by mutation of a single PKA site, Ser1700, in the proximal C-terminal domain causes reduced contractile function, cardiac hypertrophy, and heart failure without changes in expression, localization, or function of the CaV1.2 protein in the mutant mice (SA mice)...
November 18, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27863363/exercise-based-cardiac-rehabilitation-in-twelve-european-countries-results-of-the-european-cardiac-rehabilitation-registry
#17
Werner Benzer, Bernhard Rauch, Jean-Paul Schmid, Ann Dorthe Zwisler, Paul Dendale, Constantinos H Davos, Evangelia Koudi, Attila Simon, Ana Abreu, Nana Pogosova, Dan Gaita, Bojan Miletic, Gerd Bönner, Taoufik Ouarrak, Hannah McGee
AIM: Results from EuroCaReD study should serve as a benchmark to improve guideline adherence and treatment quality of cardiac rehabilitation (CR) in Europe. METHODS AND RESULTS: Data from 2.054 CR patients in 12 European countries were derived from 69 centres. 76% were male. Indication for CR differed between countries being predominantly ACS in Switzerland (79%), Portugal (62%) and Germany (61%), elective PCI in Greece (37%), Austria (36%) and Spain (32%), and CABG in Croatia and Russia (36%)...
November 11, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27862596/outcome-of-patients-with-cardiac-sarcoidosis-who-received-cardiac-resynchronization-therapy-comparison-with-dilated-cardiomyopathy-patients
#18
Kunio Yufu, Hidekazu Kondo, Tetsuji Shinohara, Kyoko Kawano, Yumi Ishii, Miho Miyoshi, Takaaki Imamura, Shotaro Saito, Norihiro Okada, Hidefumi Akioka, Yasushi Teshima, Mikiko Nakagawa, Naohiko Takahashi
INTRODUCTION: Cardiac resynchronization therapy (CRT) has been shown to be effective for patients with chronic heart failure; however, the efficacy of CRT in patients with cardiac sarcoidosis (CS) has not been established. METHODS: We compared the outcomes of patients with CS who received CRT to patients with dilated cardiomyopathy (DCM). The incidence of major adverse cerebral and cardiovascular events (MACCE) in 11 consecutive CS patients (8 females; mean age, 66±8...
November 9, 2016: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/27861471/-comparison-of-peak-oxygen-uptake-and-ve-vco2-slope-between-children-with-and-without-heart-failure
#19
Hermes Ilarraza-Lomelí, Irma Miranda Chávez, Javier Castañeda-López, Rafael Chávez-Domínguez, Carlos Felipe Barrera-Ramírez, Marianna García-Saldivia, María Dolores Rius-Suárez, Alfonso Buendía-Hernández
: Heart failure is a health problem associated with disability and mortality. Physicians may stratify the risk of adult patients with heart failure using a cardiopulmonary exercise testing. Until now, in childhood this evaluation has been poorly used. The purpose of this study is to compare the peak oxygen uptake and minute ventilation/carbon dioxide production slope among children with heart failure versus children without heart disease (control). METHODS: Thirty-eight children with heart failure were compared with 194 children without heart disease...
November 2016: Gaceta Médica de México
https://www.readbyqxmd.com/read/27860259/resp%C3%A4-ratory-muscle-strength-%C3%A4-n-pat%C3%A4-ents-w%C3%A4-th-pulmonary-hypertens%C3%A4-on-the-relat%C3%A4-onsh%C3%A4-p-w%C3%A4-th-exerc%C3%A4-se-capac%C3%A4-ty-phys%C3%A4-cal-act%C3%A4-v%C3%A4-ty-level-and-qual%C3%A4-ty-of-l%C3%A4-fe
#20
Goksen Kuran Aslan, Buket Akıncı, Ipek Yeldan, Gulfer Okumus
INTRODUCTION: Pulmonary hypertension (PH) is characterized by exertional dyspnea, fatigue, chest pain, dizziness, and syncope. Physical activity, peripheral and respiratory muscle strength reduces in pateints with PH. Little is known about respiratory muscle weakness and related outcomes. OBJECTIVES: The aims of the study were to determine respiratory muscle strength and to investigate the relationship between respiratory muscle strength and spirometric measurements, exercise capacity, physical activity level, quality of life, and pulmonary hemodynamics in patients with PH...
November 17, 2016: Clinical Respiratory Journal
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