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JOURNAL ARTICLE
Xiaohui Song, Xiangrui Sheng, Lei Ding, Jian Wu, Xin Chang, Erye Zhou, Jing Cao, Tao Cheng, Mingjun Wang
BACKGROUND: Connective tissue disease (CTD) is the second most common cause of the pulmonary arterial hypertension (PAH). Currently, clinical data concerning CTD-PAH is scarce. Our study aimed to assess the efficacy and safety of macitentan in the treatment of CTD-PAH. METHODS: In this retrospective study, patients diagnosed with CTD-PAH at The First Affiliated Hospital of Soochow University from April 2020 to November 2021 were included. Of the patients, 9 were switched to macitentan monotherapy whereas 23 received initial combination therapy...
March 29, 2024: Journal of Thoracic Disease
#2
JOURNAL ARTICLE
Kiana M Schulze, Andrew G Horn, Judy M Muller-Delp, Zachary J White, Stephanie E Hall, Steven L Medarev, Ramona E Weber, David C Poole, Timothy I Musch, Bradley J Behnke
Pulmonary hypertension (PH) is a chronic, progressive condition in which respiratory muscle dysfunction is a primary contributor to exercise intolerance and dyspnea in patients. Contractile function, blood flow distribution, and the hyperemic response are altered in the diaphragm with PH, and we sought to determine whether this may be attributed, in part, to impaired vasoreactivity of the resistance vasculature. We hypothesized that there would be blunted endothelium-dependent vasodilation and impaired myogenic responsiveness in arterioles from the diaphragm of PH rats...
April 11, 2024: Microvascular Research
#3
JOURNAL ARTICLE
Jiaying Li, Daniel Yee Tak Fong, Kris Yuet Wan Lok, Janet Yuen Ha Wong, Mandy Man Ho, Edmond Pui Hang Choi, Vinciya Pandian, Patricia M Davidson, Wenjie Duan, Marie Tarrant, Jung Jae Lee, Chia-Chin Lin, Oluwadamilare Akingbade, Khalid M Alabdulwahhab, Mohammad Shakil Ahmad, Mohamed Alboraie, Meshari A Alzahrani, Anil S Bilimale, Sawitree Boonpatcharanon, Samuel Byiringiro, Muhammad Kamil Che Hasan, Luisa Clausi Schettini, Walter Corzo, Josephine M De Leon, Anjanette S De Leon, Hiba Deek, Fabio Efficace, Mayssah A El Nayal, Fathiya El-Raey, Eduardo Ensaldo-Carrasco, Pilar Escotorin, Oluwadamilola Agnes Fadodun, Israel Opeyemi Fawole, Yong-Shian Shawn Goh, Devi Irawan, Naimah Ebrahim Khan, Binu Koirala, Ashish Krishna, Cannas Kwok, Tung Thanh Le, Daniela Giambruno Leal, Miguel Ángel Lezana-Fernández, Emery Manirambona, Leandro Cruz Mantoani, Fernando Meneses-González, Iman Elmahdi Mohamed, Madeleine Mukeshimana, Chinh Thi Minh Nguyen, Huong Thi Thanh Nguyen, Khanh Thi Nguyen, Son Truong Nguyen, Mohd Said Nurumal, Aimable Nzabonimana, Nagla Abdelrahim Mohamed Ahmed Omer, Oluwabunmi Ogungbe, Angela Chiu Yin Poon, Areli Reséndiz-Rodriguez, Busayasachee Puang-Ngern, Ceryl G Sagun, Riyaz Ahmed Shaik, Nikhil Gauri Shankar, Kathrin Sommer, Edgardo Toro, Hanh Thi Hong Tran, Elvira L Urgel, Emmanuel Uwiringiyimana, Tita Vanichbuncha, Naglaa Youssef
BACKGROUND: Central and bridge nodes can drive significant overall improvements within their respective networks. We aimed to identify them in 16 prevalent chronic diseases during the coronavirus disease 2019 (COVID-19) pandemic to guide effective intervention strategies and appropriate resource allocation for most significant holistic lifestyle and health improvements. METHODS: We surveyed 16 512 adults from July 2020 to August 2021 in 30 territories. Participants self-reported their medical histories and the perceived impact of COVID-19 on 18 lifestyle factors and 13 health outcomes...
April 12, 2024: Journal of Global Health
#4
JOURNAL ARTICLE
Sergey S Gutor, Bradley W Richmond, Vineet Agrawal, Evan L Brittain, Ciara M Shaver, Pingsheng Wu, Taryn K Boyle, Ravinder R Mallugari, Katrina Douglas, Robert N Piana, Joyce E Johnson, Robert F Miller, John H Newman, Timothy S Blackwell, Vasiliy V Polosukhin
Exertional dyspnea has been documented in U.S. military personnel after deployment to Iraq and Afghanistan. We studied whether continued exertional dyspnea in this patient population is associated with pulmonary vascular disease (PVD). We performed detailed histomorphometry of pulmonary vasculature in 52 Veterans with biopsy-proven post-deployment respiratory syndrome (PDRS) and then recruited five of these same Veterans with continued exertional dyspnea to undergo a follow-up clinical evaluation, including symptom questionnaire, pulmonary function testing, surface echocardiography, and right heart catheterization (RHC)...
April 9, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
#5
JOURNAL ARTICLE
E S Mazur, V V Mazur, N D Bazhenov, O V Nilova, T O Nikolaeva, D V Alekseev
AIM: To study the relationship between changes in left atrial volume (LAV) during exercise and the result of a diastolic stress test (DST) in patients with arterial hypertension (AH). MATERIAL AND METHODS: The study included 219 patients with AH without ischemic heart disease and atrial fibrillation. During the DST performed before and after exercise, the ratio of transmitral flow velocity to mitral annular velocity (E/e'), the left atrial global longitudinal strain in the reservoir phase (reservoir strain), and LAV were determined...
March 31, 2024: Kardiologiia
#6
JOURNAL ARTICLE
C Barrett Bowling, Richard A Faldowski, Richard Sloane, Carl Pieper, Tyson H Brown, Erin E Dooley, Brett T Burrows, Norrina B Allen, Kelley Pettee Gabriel, Cora E Lewis
BACKGROUND: Multimorbidity research has focused on the prevalence and consequences of multimorbidity in older populations. Less is known about the accumulation of chronic conditions earlier in the life course. METHODS: We identified patterns of longitudinal multimorbidity accumulation using 30 years of data from in-person exams, annual follow-ups, and adjudicated end-points among 4,945 participants of the Coronary Artery Risk Development in Young Adults (CARDIA) study...
2024: J Multimorb Comorb
#7
JOURNAL ARTICLE
Peng Zhang, Denielli Da Silva Goncalves Bos, Alexander Vang, Julia Feord, Danielle J McCullough, Alexsandra Zimmer, Natalie D'Silva, Richard T Clements, Gaurav Choudhary
Reduced exercise capacity in pulmonary hypertension (PH) significantly impacts quality of life. However, the cause of reduced exercise capacity in PH remains unclear. The objective of this study was to investigate whether intrinsic skeletal muscle changes are causative in reduced exercise capacity in PH using preclinical PH rat models with different PH severity. PH was induced in adult Sprague-Dawley (SD) or Fischer (CDF) rats with one dose of SU5416 (20 mg/kg) injection, followed by 3 weeks of hypoxia and additional 0-4 weeks of normoxia exposure...
April 2024: Pulmonary Circulation
#8
JOURNAL ARTICLE
Aaron B Waxman, David M Systrom, Solaiappan Manimaran, Janethe de Oliveira Pena, Jonathan Lu, Franz P Rischard
BACKGROUND: This study aims to assess the impact of sotatercept on exercise tolerance, exercise capacity, and right ventricular function in pulmonary arterial hypertension. METHODS: SPECTRA (Sotatercept Phase 2 Exploratory Clinical Trial in PAH) was a phase 2a, single-arm, open-label, multicenter exploratory study that evaluated the effects of sotatercept by invasive cardiopulmonary exercise testing in participants with pulmonary arterial hypertension and World Health Organization functional class III on combination background therapy...
April 4, 2024: Circulation. Heart Failure
#9
Sojwal P Nandanwar, Lajwanti Lalwani, Priyanka K Chilhate
Pneumonia is an infection that causes inflammation in the air sacs of the lungs. Coronary artery disease is a condition characterized by the buildup of plaque in the coronary arteries, which supply blood to the heart. This obstruction restricts blood flow, resulting in chest pain (angina) and, in extreme cases, heart attacks. An important part of successfully treating diseases like peripheral artery disease and coronary artery disease is balloon angioplasty, a commonly used medical procedure for treating narrowed or clogged arteries...
March 2024: Curēus
#10
JOURNAL ARTICLE
Paul J Critser, Terry L Buchmiller, Kimberlee Gauvreau, Jill M Zalieckas, Catherine A Sheils, Gary A Visner, Keri M Shafer, Ming Hui Chen, Mary P Mullen
OBJECTIVE: To determine the prevalence of exercise-induced pulmonary hypertension (PH) among long-survivors of congenital diaphragmatic hernia (CDH) repair. STUDY DESIGN: This is a single-center, retrospective cohort study of CDH survivors who underwent exercise stress echocardiography (ESE) at Boston Children's Hospital from January 2006 to June 2020. PH severity was assessed by echocardiogram at baseline and after exercise. Patients were categorized by right ventricular systolic pressure (RVSP) after exercise: Group 1 - no or mild PH; and Group 2 - moderate or severe PH (RVSP ≥ 60 mmHg or ≥ ½ systemic blood pressure)...
March 27, 2024: Journal of Pediatrics
#11
REVIEW
Mithum Kularatne, Christian Gerges, Mitja Jevnikar, Marc Humbert, David Montani
Pulmonary hypertension (PH) refers to a pathologic elevation of the mean pulmonary artery pressure (mPAP) and is associated with increased morbidity and mortality in a wide range of medical conditions. These conditions are classified according to similarities in pathophysiology and management in addition to their invasive hemodynamic profiles. The 2022 ESC/ERS guidelines for the diagnosis and treatment of pulmonary hypertension present the newest clinical classification system and includes significant updates to the hemodynamic definitions...
February 27, 2024: Journal of Cardiovascular Development and Disease
#12
JOURNAL ARTICLE
F Joachim Meyer, Christian Opitz
In survivors of acute pulmonary embolism (PE), the post-PE syndrome (PPES) may occur. In PPES, patients typically present with persisting or progressive dyspnea on exertion despite 3 months of therapeutic anticoagulation. Therefore, a structured follow-up is warranted to identify patients with chronic thromboembolic pulmonary disease (CTEPD) with normal pulmonary pressure or chronic thromboembolic pulmonary hypertension (CTEPH). Both are currently understood as a dual vasculopathy, that is, secondary arterio- and arteriolopathy, affecting the large and medium-sized pulmonary arteries as well as the peripheral vessels (diameter < 50 µm)...
March 26, 2024: Hämostaseologie
#13
JOURNAL ARTICLE
Ahmed Youssouf Addou, Wafa El Mire, Nawal Doghmi, Aatif Benyass
BACKGROUND: Gaucher disease (GD) is a lysosomal storage disease that leads to the accumulation of glucocerebroside within reticuloendothelial cells, haematological, neurological, skeletal and abdominal organs. These clinical manifestations are common to all types of GD, but categorization depends on the absence of neurological involvement (type I) or its presence (type II and III). Cardiac involvement is rare and only reported in few cases, where valvular and aortic calcifications were associated with type IIIc...
March 24, 2024: Egyptian Heart Journal: EHJ
#14
JOURNAL ARTICLE
Jason Weatherald, Steven D Nathan, Karim El-Kersh, Rahul G Argula, Hilary M DuBrock, Franz P Rischard, Steven J Cassady, James Tarver, Deborah J Levine, Victor F Tapson, Chunqin Deng, Eric Shen, Manisit Das, Aaron B Waxman
BACKGROUND: Inhaled treprostinil (iTre) is the only treatment approved for pulmonary hypertension due to interstitial lung disease (PH-ILD) to improve exercise capacity. This post hoc analysis evaluated clinical worsening and PH-ILD exacerbations from the 16-week INCREASE study and change in 6-minute walking distance (6MWD) in the INCREASE open-label extension (OLE) in patients with less severe haemodynamics. METHODS: Patients were stratified by baseline pulmonary vascular resistance (PVR) of <4 Wood units (WU) versus ≥4 WU and <5 WU versus ≥5 WU...
March 22, 2024: BMJ Open Respiratory Research
#15
JOURNAL ARTICLE
Chang-Ying Chen, Wang Mei-Tzu, Shih-Hsien Sung, Yih-Jer Wu, Chih-Hsin Hsu, Wan-Jing Ho, Yen-Hung Lin, Wei-Shin Liu, Ju-Chi Liu, Yung-Ta Kao, Wen-Shiann Wu, Chun-Hsien Wu, Meng-Huan Lei, Yu-Wei Chen, Chien Chen-Yu, Yu-Wei Chiu, Zen-Kong Dai, Tsung-Hsien Lin, Lin Lin, Cheng-Chih Chung, Chang-Min Chung, Sung-Hao Huang, Chin-Chang Cheng, Yen-Wen Wu, Ting-Hsing Chao, Juey-Jen Hwang, Charles Jia-Yin Hou, Wei-Chun Huang
BACKGROUND: Demographics of pulmonary hypertension (PH) has changed a lot over the past forty years. Several recent registries noted an increase in mean age of PH but only a few of them investigated the characteristics of elderly patients. Thus, we aimed to analyze the characteristics of PH in such a population in this study. METHODS: This multicenter study enrolled patients diagnosed with PH in group 1, 3, 4, and 5 consecutively from January 1, 2019 to December 31, 2020...
March 30, 2024: Heliyon
#16
JOURNAL ARTICLE
Min Sun Kim, Kina Jeon, Eun Kyoung Kim, Taek Kyu Park, Hye Yun Park, Jeong Hoon Yang, Sung-Ji Park, Sang-Chol Lee, Seung Woo Park, Duk-Kyung Kim, Sung-A Chang
PURPOSE: Chronic thromboembolic pulmonary disease (CTEPD) can lead to exercise limitations even without right ventricular (RV) dysfunction or pulmonary hypertension at rest. Combining exercise stress echocardiography with cardiopulmonary exercise testing (ESE-CPET) for RV function and pressure changes combined measuring overall function may be useful for CTEPD evaluation. This study aims to investigate CPET and ESE results to elucidate the mechanisms of exercise limitation in mild CTEPD cases...
March 2024: Echocardiography
#17
Vanessa C Perez, Veronica Williams, Franck F Rahaghi
Oral treprostinil, approved for the treatment of pulmonary arterial hypertension, remains an attractive option in combination with other medications to delay disease progression and improve exercise capacity. However, patients are often challenged with the ability to overcome adverse effects as outpatients and reach effective doses in a timely manner. We describe a case of a 47-year-old female on oral treprostinil who presented to the clinic with worsening symptoms of disease, necessitating higher dosing. This patient was previously uptitrated outpatient with oral treprostinil, which had allowed her to remain stable for years...
February 2024: Curēus
#18
JOURNAL ARTICLE
Piotr Mieszczański, Marek Janiak, Paweł Ziemiański, Radosław Cylke, Wojciech Lisik, Janusz Trzebicki
BACKGROUND Patients with obesity with interstitial lung diseases (ILD) are encouraged to lose weight, as it improves lung function and lung transplant eligibility. As exercise tolerance in these patients is low and weight gain is a common adverse effect of corticosteroids, bariatric surgery can be an effective method for the management of obesity in this patient group. However, perioperative complications in such high-risk patients remain a concern. Therefore, we aimed to demonstrate successful anesthetic management for obese patients with ILD, which may be practically utilized to reduce perioperative pulmonary complications and improve outcomes...
March 19, 2024: American Journal of Case Reports
#19
JOURNAL ARTICLE
Qin-Hua Zhao, Jun Chen, Fa-Dong Chen, Hong-Yun Ruan, Wei Zhang, Yan-Li Zhou, Qi-Qi Wang, Xiao-Ling Xu, Ke-Fu Feng, Jian-Zhou Guo, Su-Gang Gong, Rui-Feng Zhang, Lan Wang
This study aimed to evaluate the effectiveness and safety of an oral sequential triple combination therapy with selexipag after dual combination therapy with endothelin receptor antagonist (ERA) and phosphodiesterase-5 inhibitor (PDE5I)/riociguat in pulmonary arterial hypertension (PAH) patients. A total of 192 PAH patients from 10 centers had received oral sequential selexipag therapy after being on dual-combination therapy with ERA and PDE5i/riociguat for a minimum of 3 months. Clinical data were collected at baseline and after 6 months of treatment...
January 2024: Pulmonary Circulation
#20
JOURNAL ARTICLE
Han Shi, Yuan Yuan, Xue Li, Yan-Fang Li, Ling Fan, Xue-Mei Yang
BACKGROUND: In China, the prevalence of type 2 diabetes mellitus (T2DM) among diabetic patients is estimated to be between 90%-95%. Additionally, China is among the 22 countries burdened by a high number of tuberculosis cases, with approximately 4.5 million individuals affected by active tuberculosis. Notably, T2DM poses a significant risk factor for the development of tuberculosis, as evidenced by the increased incidence of T2DM coexisting with pulmonary tuberculosis (T2DM-PTB), which has risen from 19...
February 15, 2024: World Journal of Diabetes
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