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https://www.readbyqxmd.com/read/28098192/wearable-atmospheric-pressure-plasma-fabrics-produced-by-knitting-flexible-wire-electrodes-for-the-decontamination-of-chemical-warfare-agents
#1
Heesoo Jung, Jin Ah Seo, Seungki Choi
One of the key reasons for the limited use of atmospheric pressure plasma (APP) is its inability to treat non-flat, three-dimensional (3D) surface structures, such as electronic devices and the human body, because of the rigid electrode structure required. In this study, a new APP system design-wearable APP (WAPP)-that utilizes a knitting technique to assemble flexible co-axial wire electrodes into a large-area plasma fabric is presented. The WAPP device operates in ambient air with a fully enclosed power electrode and grounded outer electrode...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28093363/alignment-of-collagen-fiber-in-knitted-silk-scaffold-for-functional-massive-rotator-cuff-repair
#2
Zefeng Zheng, Jisheng Ran, Weishan Chen, Yejun Hu, Ting Zhu, Xiao Chen, Zi Yin, Boon Chin Heng, Gang Feng, Huihui Le, Chenqi Tang, Jiayun Huang, Yangwu Chen, Yiting Zhou, Pioletti Dominique, Weiliang Shen, Hong-Wei Ouyang
: Rotator cuff tear is one of the most common types of shoulder injuries, often resulting in pain and physical debilitation. Allogeneic tendon-derived decellularized matrices do not have appropriate pore size and porosity to facilitate cell infiltration, while commercially-available synthetic scaffolds are often inadequate at inducing tenogenic differentiation. The aim of this study is to develop an advanced 3D aligned collagen/silk scaffold (ACS) and investigate its efficacy in a rabbit massive rotator cuff tear model...
January 13, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28088344/design-control-considerations-for-biologic-device-combination-products
#3
Dave Anderson, Roger Liu, J Anand Subramony, Jon Cammack
Combination products are therapeutic and diagnostic medical products that combine drugs, devices, and/or biological products with one another. Historically, biologics development involved identifying efficacious doses administered to patients intravenously or perhaps by a syringe. Until fairly recently, there has been limited focus on developing an accompanying medical device, such as a prefilled syringe or auto-injector, to enable easy and more efficient delivery. For the last several years, and looking forward, where there may be little to distinguish biologics medicines with relatively similar efficacy profiles, the biotechnology market is beginning to differentiate products by patient-focused, biologic-device based combination products...
January 11, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28049476/an-improved-extraction-method-for-surface-dosage-of-insecticides-on-treated-textile-fabrics
#4
Florence Dieval, Jérémy Bouyer, Jean-François Fafet
BACKGROUND: Tens of millions of people live in mosquito-infested regions and controlling mosquito-borne diseases is one of the major interventions aimed at alleviating poverty worldwide. The use of insecticide-treated textiles is one of the most widespread control measures. This includes bed nets, battle clothing or, more generally, textiles use for clothing. These textiles are generally treated with permethrin as active ingredient, which is dosed after extraction of the active molecule present throughout the fabric (measured in mg permethrin/g of fabric) and does not take the effective concentration on the textile surfaces into account...
January 4, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28038405/comprehensive-mechanical-characterization-of-pla-fabric-combined-with-pcl-to-form-a-composite-structure-vascular-graft
#5
Chaojing Li, Fujun Wang, Graeham Douglas, Ze Zhang, Robert Guidoin, Lu Wang
Vascular grafts made by tissue engineering processes are prone to buckling and twisting, which can impede blood flow and lead to collapse of the vessel. These vascular conduits may suffer not only from insufficient tensile strength, but also from vulnerabilities related to compression, torsion, and pulsatile pressurization. Aiming to develop a tissue engineering-inspired blood conduit, composite vascular graft (cVG) prototypes were created by combining a flexible polylactic acid (PLA) knitted fabric with a soft polycaprolactone (PCL) matrix...
December 15, 2016: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28034577/10-lessons-learned-by-a-misguided-physician
#6
REVIEW
Barry E Levin
It was a great and humbling honor to receive the 2016 Distinguished Career Award from my SSIB colleagues. This paper summarizes the major points of my DCA talk at the 2016 annual meeting. It is a reflection on my 50year medical and research career and 10 lessons I have learned over those years which might be of help to young investigators near the beginning of their own research careers. These lessons include: the value of being receptive to the opportunities provided you; how clinician-scientists can serve as critical role models for young investigators like me and a history of how my career developed as a result of their influence; the importance of carefully examining your own data, particularly when it doesn't agree with your preconceived ideas; the critical role that students, postdocs and PhD (and even veterinarian) colleagues can play in developing one's career; the likelihood that your career path will have many interesting twists and turns determined by changes in your own scientific interests and how rewarding various areas of research focus are to you; the importance of building a close-knit laboratory staff family; the fact that science and romance can mix...
December 26, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/28028595/comprehensive-two-dimensional-gas-chromatographic-profiling-and-chemometric-interpretation-of-the-volatile-profiles-of-sweat-in-knit-fabrics
#7
A Paulina de la Mata, Rachel H McQueen, Seo Lin Nam, James J Harynuk
Human axillary sweat is a poorly explored biofluid within the context of metabolomics when compared to other fluids such as blood and urine. In this paper, we explore the volatile organic compounds emitted from two different types of fabric samples (cotton and polyester) which had been worn repeatedly during exercise by participants. Headspace solid-phase microextraction (SPME) and comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry (GC×GC-TOFMS) were employed to profile the (semi)volatile compounds on the fabric...
December 27, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28028520/evaluation-of-structural-and-mechanical-properties-of-electrospun-nano-micro-hybrid-of-poly-hydroxybutyrate-chitosan-silk-scaffold-for-cartilage-tissue-engineering
#8
Saeed Karbasi, Farnoosh Fekrat, Daryoush Semnani, Shahnaz Razavi, Elham Naghash Zargar
BACKGROUND: One of the new methods of scaffold fabrication is a nano-micro hybrid structure in which the properties of the scaffold are improved by introducing nanometer and micrometer structures. This method could be suitable for scaffold designing if some features improve. MATERIALS AND METHODS: In this study, electrospun nanofibers of 9% weight solution of poly (3-hydroxybutyrate) (P3HB) and a 15% weight of chitosan by trifluoroacetic acid were coated on both the surface of a silk knitted substrate in the optimum condition to improve the mechanical properties of scaffolds for cartilage tissue engineering application...
2016: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28027084/caring-for-the-amish-what-every-anesthesiologist-should-know
#9
Gregory E R Weller
The Amish are a relatively isolated group with cultural and religious customs that differ significantly from the mainstream American population. Functioning as tight-knit communities with strong conservative Christian beliefs, the Amish maintain a culture based on intentional separateness from the outside world. Key aspects of Amish life include distinct clothing and behaviors, a unique language, an agrarian lifestyle, limited formal education, nonviolence/nonaggression, and a general lack of modern technology, as exemplified by the use of the traditional horse-and-buggy...
December 22, 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27999810/development-of-a-new-hybrid-biodegradable-drug-eluting-stent-for-the-treatment-of-peripheral-artery-disease
#10
Jung-Hee Lee, Soon-Joong Kim, Se-Il Park, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang
This study aimed to develop a new biodegradable stent for peripheral artery disease (PAD) that could provide sufficient radial force to maintain long-term patency and flexibility. All self-expandable hybrid biodegradable stents were designed by using a knitting structure composed of poly-L-lactic acid (PLLA) and nitinol. Four different types of stents were implanted in 20 iliac arteries in 10 mini pigs as follows: a bare-metal stent (BMS) (group 1, n = 5), a drug-free hybrid stent (group 2, n = 5), a 50% (50 : 100, w/w) paclitaxel (PTX)/poly-lactide-co-glycolic acid (PLGA; fast PTX-releasing form) hybrid stent (group 3, n = 5), and a 30% (30 : 100, w/w) PTX/PLGA (slow PTX-releasing form) hybrid stent (group 4, n = 5)...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27990114/sparing-surgery-for-the-successful-treatment-of-thyroid-papillary-carcinoma-invading-the-trachea-a-case-report
#11
Denis Kulbakin, Timofey Chekalkin, Marat Muhamedov, Evgeniy Choynzonov, Ji-Hoon Kang, Seung-Baik Kang, Victor Gunther
Published reports on salvage treatment for trachea reconstruction after total thyroidectomy or partial tracheotomy are available, some of them using structures of the trachea itself, auricular cartilage, a musculocutaneous flap, or other methods. In our report, we emphasize the importance of a search for a new material and approach for sparing surgery. The purpose of this article is to describe a case of a successful sparing surgery in a patient with advanced thyroid papillary carcinoma invading the trachea...
September 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27989108/quantification-of-total-n-nitrosamine-concentrations-in-aqueous-samples-via-uv-photolysis-and-chemiluminescence-detection-of-nitric-oxide
#12
Florian Breider, Urs von Gunten
N-nitrosamines are potent mutagens and carcinogens that can be formed during oxidative water treatment. This study describes a novel method for the determination of total N-nitrosamines by UV-photolysis and subsequent chemiluminescence detection of nitric oxide. Denitrosation of N-nitrosamines was accomplished with a microphotochemical reactor consisting of a knitted reaction coil and a low-pressure mercury lamp. The detection limits for differing N-nitrosamines ranged between 0.07 μM (14 pmol injected) and 0...
December 19, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27931575/bile-duct-anastomosis-supplied-with-biodegradable-stent-in-liver-transplantation-the-initial-experience
#13
L Janousek, S Maly, M Oliverius, M Kocik, M Kucera, J Fronek
BACKGROUND: The most common biliary complications after orthotopic liver transplantation are bile leaks, anastomotic and intrahepatic strictures, stones, and ampullary dysfunction. These complications can occur in up to 10% to 30% of liver transplant recipients. Leaks occur early in the posttransplant period; the stricture formation typically graduates over time. METHODS: Ten patients underwent transplantation in our preliminary study: 5 were randomized to the group with stent placement and 5 to the control group...
December 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27905601/an-atlas-of-endohedral-sc2s-cluster-fullerenes
#14
Li-Hua Gan, Rui Wu, Jian-Lei Tian, Patrick W Fowler
Structural identification is a difficult task in the study of metallofullerenes, but understanding of the mechanism of formation of these structures is a pre-requisite for new high-yield synthetic methods. Here, systematic density functional theory calculations demonstrate that metal sulfide fullerenes Sc2S@Cn have similar cage geometries from C70 to C84 and form a close-knit family of structures related by Endo-Kroto insertion/extrusion of C2 units and Stone-Wales isomerization transformations. The stabilities predicted for favoured isomers by DFT calculations are in good agreement with available experimental observations, have implications for the formation of metallofullerenes, and will aid structural identification from within the combinatorially vast pool of conceivable isomers...
December 21, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27886727/you-can-t-always-get-what-you-want-network-determinants-of-relationship-inactualization-in-adolescence
#15
Rachel L Behler
Despite widespread interest in the link between social and sexual networks, little research has focused on how social networks influence the progression of intimate relationships (e.g., from holding hands to sexual intercourse). I argue that social networks not only affect individuals' opportunities to meet romantic partners, but also shape the ideal and actual progressions of intimate acts within their relationships. Using data from the National Longitudinal Survey of Adolescent to Adult Health (Add Health), I conduct an optimal matching analysis of adolescents' purported ideal versus actual relationship sequences, which are comprised of romantic and sexual events...
January 2017: Social Science Research
https://www.readbyqxmd.com/read/27865400/new-mycobacterium-tuberculosis-lam-sublineage-with-geographical-specificity-for-the-old-world-revealed-by-phylogenetical-and-bayesian-analyses
#16
Yann Reynaud, Nalin Rastogi
We recently showed that the Mycobacterium tuberculosis sublineage LAM9 could be subdivided as two distinct subpopulations - each reflecting its unique biogeographical structure and evolutionary history. We subsequently attempted to verify if this genetic structuration could be traced in an enlarged global sample. For this purpose, we analyzed global evolutionary relationships of LAM strains in a large dataset (n = 1923 isolates from 35 countries worldwide) with concomitant spoligotyping and MIRU-VNTR data, followed by a deeper analysis of LAM9 sublineage (n = 851 isolates)...
December 2016: Tuberculosis
https://www.readbyqxmd.com/read/27805565/computationally-designed-high-specificity-inhibitors-delineate-the-roles-of-bcl2-family-proteins-in-cancer
#17
Stephanie Berger, Erik Procko, Daciana Margineantu, Erinna F Lee, Betty W Shen, Alex Zelter, Daniel-Adriano Silva, Kusum Chawla, Marco J Herold, Jean-Marc Garnier, Richard Johnson, Michael J MacCoss, Guillaume Lessene, Trisha N Davis, Patrick S Stayton, Barry L Stoddard, W Douglas Fairlie, David M Hockenbery, David Baker
Many cancers overexpress one or more of the six human pro-survival BCL2 family proteins to evade apoptosis. To determine which BCL2 protein or proteins block apoptosis in different cancers, we computationally designed three-helix bundle protein inhibitors specific for each BCL2 pro-survival protein. Following in vitro optimization, each inhibitor binds its target with high picomolar to low nanomolar affinity and at least 300-fold specificity. Expression of the designed inhibitors in human cancer cell lines revealed unique dependencies on BCL2 proteins for survival which could not be inferred from other BCL2 profiling methods...
November 2, 2016: ELife
https://www.readbyqxmd.com/read/27798709/association-between-social-network-characteristics-and-lifestyle-behaviours-in-adults-at-risk-of-diabetes-and-cardiovascular-disease
#18
Sandra D Bot, Joreintje D Mackenbach, Giel Nijpels, Jeroen Lakerveld
OBJECTIVES: In this exploratory study we examined the associations between several social network characteristics and lifestyle behaviours in adults at increased risk of diabetes and cardiovascular diseases. In addition, we explored whether similarities in lifestyle between individuals and their network members, or the level of social support perceived by these individuals, could explain these associations. METHODS: From the control group of the Hoorn Prevention Study, participants with high and low educational attainment were approached for a structured interview between April and August 2010...
2016: PloS One
https://www.readbyqxmd.com/read/27794440/fabrication-of-biodegradable-textile-scaffold-based-on-hydrophobized-hyaluronic-acid
#19
Vojtech Zapotocky, Martina Pospisilova, Katerina Janouchova, Daniel Svadlak, Jana Batova, Jana Sogorkova, Martin Cepa, Jiri Betak, Veronika Stepankova, Romana Sulakova, Jaromir Kulhanek, Tomas Pitucha, Jana Vranova, Garry Duffy, Vladimir Velebny
In this work, we report on the preparation of a novel biodegradable textile scaffold made of palmitoyl-hyaluronan (palHA). Monofilament fibres of palHA with a diameter of 120μm were prepared by wet spinning. The wet-spun fibres were subsequently processed into a warp-knitted textile. To find a compromise between swelling in water and degradability of the final textile scaffold, a series of palHA derivatives with different degrees of substitution of the palmitoyl chain was synthesized. Freeze-drying not only provided shape fixation, but also speeded up scaffold degradation in vitro...
February 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27786565/the-electromagnetic-basis-of-social-interactions
#20
A R Liboff
It has been established that living things are sensitive to extremely low-frequency magnetic fields at vanishingly small intensities, on the order of tens of nT. We hypothesize, as a consequence of this sensitivity, that some fraction of an individual's central nervous system activity can be magnetically detected by nearby individuals. Even if we restrict the information content of such processes to merely simple magnetic cues that are unconsciously received by individuals undergoing close-knit continuing exposure to these cues, it is likely that they will tend to associate these cues with the transmitting individual, no less than would occur if such signals were visual or auditory...
2017: Electromagnetic Biology and Medicine
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