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Vitamin deficiency

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https://www.readbyqxmd.com/read/29232067/clinical-factors-are-associated-with-vitamin-d-levels-in-ibd-patients-a-retrospective-analysis
#1
Holger Schäffler, Martin Schmidt, Astrid Huth, Johannes Reiner, Änne Glass, Georg Lamprecht
INTRODUCTION: There is growing evidence for the hypothesis, that vitamin D deficiency plays a role in the development and the disease course of IBD. However, the correlation of vitamin D deficiency to clinical parameters in IBD is still not completely understood. MATERIAL AND METHODS: A retrospective study of IBD patients was performed. Vitamin D values were analyzed and correlated to clinical parameters like medical therapy, anatomical situation, localization of the disease and disease activity...
December 12, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29231753/rates-of-insufficiency-and-deficiency-of-vitamin-d-levels-in-elite-professional-male-and-female-skiers-a-chronobiologic-approach
#2
Jacopo Antonino Vitale, Giovanni Lombardi, Luca Cavaleri, Rosa Graziani, Herbert Schoenhuber, Antonio La Torre, Giuseppe Banfi
Vitamin D is essential for the maintenance and promotion of musculoskeletal health, for the functioning of the immune, cardiovascular and reproductive systems, and its main action is to keep calcium and phosphate plasmatic physiological concentrations at intestinal, renal and bony level. Vitamin D affects several parameters related to physical performance too and a particularly high percentage of vitamin D insufficiency and deficiency in professional athletes has been observed. Several variables are able to impair the synthesis of 25(OH)D in athletes, specifically both genetic and environmental factors, but the most probable explanation for the deficient/insufficient vitamin D levels is the insufficient ultraviolet B light (UVB) exposure during winter...
December 12, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29230557/seasonal-variation-of-serum-vitamin-d-levels-in-romania
#3
Dan Alexandru Niculescu, Cristina Ana Maria Capatina, Roxana Dusceac, Andra Caragheorgheopol, Adina Ghemigian, Catalina Poiana
We measured serum vitamin D in 8024 Romanian subjects and found a marked seasonal variation with highest levels in September and lowest levels in March. The seasonal variation (early autumn vs. early spring) persisted in all age and sex groups. The prevalence of vitamin D deficiency was very high. PURPOSE: Romania is located in Eastern Europe, roughly between 44°N and 48°N latitude. Seasonal variation of serum vitamin D in Romanian subjects is unknown. We assessed the seasonal variation of 25-hydroxy vitamin D [25(OH)D] in Romanian population...
December 11, 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29230421/association-of-vitamin-d-deficiency-and-degree-of-coronary-artery-disease-in-cardiac-patients-with-type-2-diabetes
#4
Ewelina A Dziedzic, Jakub S Gąsior, Mariusz Pawłowski, Marek Dąbrowski
Several modifiable factors may influence cardiac function in diabetic patients. The aim of the study was to evaluate the influence of vitamin D level on the stage of coronary atherosclerosis in cardiac patients diagnosed with type 2 diabetes. The study was performed in 337 consecutive patients undergoing coronarography. The stage of atherosclerosis was evaluated using Coronary Artery Surgery Study Score. The plasma 25(OH)D concentration was determined by an electrochemiluminescence method. Patients without significant lesions in coronary arteries presented the highest 25(OH)D level, significantly higher than patients with one-, two-, and three-vessel coronary artery disease (CAD) (p < 0...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29230333/celiac-disease-in-patients-with-cystic-fibrosis-related-bone-disease
#5
Melissa S Putman, Alexandra Haagensen, Isabel Neuringer, Leonard Sicilian
Both cystic fibrosis (CF) and celiac disease can cause low bone mineral density (BMD) and fractures. Celiac disease may occur at a higher frequency in patients with CF than the general population, and symptoms of these conditions may overlap. We report on two patients presenting with CF-related bone disease in the past year who were subsequently found to have concurrent celiac disease. Because adherence to a gluten-free diet may improve BMD in patients with celiac disease, this could have important implications for treatment...
2017: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/29229962/reference-and-influential-factors-of-serum-bone-markers-in-chinese-adolescents
#6
Xinyi Wang, Lichao Liu, Ping Li, Jie Ma, Ranhua Jiang, Renee Wang, Ling Li, Haixia Guan
This study aimed to establish reference ranges of bone markers in Chinese adolescents between the age of 12 and 16, and to search these markers' characteristics and influential factors. Personal information and fasting blood samples were collected from 174 healthy adolescents in Northeast China. Serum levels of PINP, ALP, β-CrossLaps, calcium, phosphate, PTH, 25(OH)D and TSH were measured. Reference ranges were established for PINP [(85.55-2,028.75)ng/ml], ALP [(53.88-463.63)U/L], β-CrossLaps [(0.16-1.19)ng/ml], calcium [(2...
December 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29228951/hypovitaminosis-c-and-vitamin-c-deficiency-in-critically-ill-patients-despite-recommended-enteral-and-parenteral-intakes
#7
Anitra C Carr, Patrice C Rosengrave, Simone Bayer, Steve Chambers, Jan Mehrtens, Geoff M Shaw
BACKGROUND: Vitamin C is an essential water-soluble nutrient which cannot be synthesised or stored by humans. It is a potent antioxidant with anti-inflammatory and immune-supportive roles. Previous research has indicated that vitamin C levels are depleted in critically ill patients. In this study we have assessed plasma vitamin C concentrations in critically ill patients relative to infection status (septic shock or non-septic) and level of inflammation (C-reactive protein concentrations)...
December 11, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29227833/vitamin-a-deficiency-in-mice-alters-host-and-gut-microbial-metabolism-leading-to-altered-energy-homeostasis
#8
Yuan Tian, Robert G Nichols, Jingwei Cai, Andrew D Patterson, Margherita T Cantorna
Vitamin A deficiency (A-) is a worldwide public health problem. To better understand how vitamin A status influences gut microbiota and host metabolism, we systematically analyzed urine, cecum, serum and liver samples from vitamin A sufficient (A+) and deficient (A-) mice using 1H NMR-based metabolomics, quantitative (q)PCR and 16S rRNA gene sequencing coupled with multivariate data analysis. The microbiota in the cecum of A- mice showed compositional as well as functional shifts compared to the microbiota from A+ mice...
November 5, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29227493/prophylactic-role-of-vitamin-k-supplementation-on-vascular-inflammation-in-type-2-diabetes-by-regulating-the-nf-%C3%AE%C2%BAb-nrf2-pathway-via-activating-gla-proteins
#9
Anjum Dihingia, Dibyajyoti Ozah, Pranab Kumar Baruah, Jatin Kalita, Prasenjit Manna
There is no previous study that has examined the relationship between circulating vitamin K1 (VK1) and vascular inflammation in type 2 diabetes (T2D). This study aims to examine the hypothesis that circulating VK1 deficiency may be associated with higher inflammation and insulin resistance in T2D patients and that VK1 supplementation regulates the NF-κB/Nrf2 pathway via activating VK-dependent Gla proteins and reduces vascular inflammation. The results showed that plasma VK1 levels were significantly lower and MCP-1, fasting glucose, HbA1c, and insulin resistance (HOMA-IR) were significantly higher in T2D patients compared to those in the controls...
December 11, 2017: Food & Function
https://www.readbyqxmd.com/read/29226809/vitamin-d-supplementation-in-chronic-schizophrenia-patients-treated-with-clozapine-a-randomized-double-blind-placebo-controlled-clinical-trial
#10
Amir Krivoy, Roy Onn, Yael Vilner, Eldar Hochman, Shira Weizman, Amir Paz, Shmuel Hess, Roi Sagy, Shiri Kimhi-Nesher, Ehud Kalter, Tal Friedman, Zvi Friedman, Gil Bormant, Sharon Trommer, Avi Valevski, Abraham Weizman
BACKGROUND: While accumulating evidence suggests that vitamin D deficiency may be involved in the risk to develop schizophrenia and its outcome, there are no studies on vitamin D supplementation in this context. We sought to assess the effect of vitamin D supplementation on psychiatric, cognitive and metabolic parameters in chronic clozapine-treated schizophrenia patients. METHODS: This eight-week, randomized, double-blind, placebo-controlled clinical trial, recruited schizophrenia patients who had been maintained on clozapine treatment for at least 18weeks and had low levels of vitamin D (<75nmol/l) and total PANSS scores >70 (to ascertain the presence of residual symptoms)...
December 2, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29225928/causes-of-severe-visual-impairment-and-blindness-in-students-in-schools-for-the-blind-in-northwest-ethiopia
#11
Mulusew Asferaw, Geoffrey Woodruff, Clare Gilbert
Objectives: To determine the causes of severe visual impairment and blindness (SVI/BL) among students in schools for the blind in Northwest Ethiopia and to identify preventable and treatable causes. Method: Students attending nine schools for the blind in Northwest Ethiopia were examined and causes assigned using the standard WHO record form for children with blindness and low vision in May and June 2015. Results: 383 students were examined, 357 (93%) of whom were severely visually impaired or blind (<6/60 in their better eye)...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29225484/the-prevalence-of-iron-deficiency-anemia-and-its-associated-risk-factors-among-a-sample-of-female-university-students-in-tabuk-saudi-arabia
#12
Riyadh A Alzaheb, Osama Al-Amer
Background: Prior data on iron deficiency anemia's (IDA) prevalence and associated risk factors among female university students are scarce in the Saudi Arabian context. This study therefore recruited a sample of female students at the University of Tabuk, Saudi Arabia, to investigate IDA prevalence and risk factors and fill the identified research gap. Methods: A cross-sectional study of 200 apparently healthy female students aged between 19 and 25 years was performed between February and June 2016...
2017: Clinical Medicine Insights. Women's Health
https://www.readbyqxmd.com/read/29225312/prevalence-and-trends-of-vitamin-d-deficiency-among-iranian-adults-a-longitudinal-study-from-2001-2013
#13
Hossein Khosravi-Boroujeni, Nizal Sarrafzadegan, Masoumeh Sadeghi, Hamidreza Roohafza, Shu-Kay Ng, Ali Pourmogaddas, Faruk Ahmed
Vitamin D deficiency/insufficiency is currently considered to be a re-emerging public health problem globally. This study was designed to determine the prevalence of vitamin D deficiency and insufficiency and to investigate its trend from 2001 to 2013 in a longitudinal study of Iranian adults. This study was part of a population-based, longitudinal ongoing study of Iranian healthy adults aged 35 y and older at baseline. Serum vitamin D level was assessed in a sub-sample of 370 subjects, who were apparently healthy at the time of recruitment in 2001 and were free from MetS, in three phases (2001, 2007 and 2013) during the 12-y study period...
2017: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/29223041/understanding-motivations-for-dietary-supplementation-during-pregnancy-a-focus-group-study
#14
Lenka Malek PhD, Wendy J Umberger PhD, Maria Makrides PhD, Carmel T Collins PhD, Shao Jia Zhou PhD
OBJECTIVE: to increase understanding of psychosocial factors (behavioural, normative and control beliefs) motivating vitamin and mineral supplement use during pregnancy. DESIGN: ten focus group discussions and two in-depth interviews were conducted using a script comprising questions based on study objectives. All discussions were recorded, transcribed verbatim and analysed using a framework approach. SETTING: South Australia, Australia. SUBJECTS: 40 women aged 21-45 years who were either pregnant or<12 months postpartum...
November 26, 2017: Midwifery
https://www.readbyqxmd.com/read/29222903/vitamin-d-status-and-cardiometabolic-risk-factors-in-young-adults-in-hong-kong-associations-and-implications
#15
Erica Wei-Lan Wang, Marco Yiu-Chung Pang, Parco Ming-Fai Siu, Claudia Kam-Yuk Lai, Jean Woo, Andrew R Collins, Iris Ff Benzie
BACKGROUND AND OBJECTIVES: Vitamin D deficiency is reportedly common, but we lack data from young adults. Such data are of interest because epidemiological data support vitamin D as a possible risk modulator for diabetes and cardiovascular ('cardiometabolic') disease. Our objectives were to assess vitamin D status (as plasma 25(OH)D concentration) and investigate associations between this and biomarkers of cardiometabolic disease risk in a group of still-healthy young adults in Hong Kong...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29222896/serum-vitamin-b-12-in-children-presenting-with-vasovagal-syncope
#16
Ayhan Pektas, Resit Koken, Halit Bugra Koca
BACKGROUND AND OBJECTIVES: The present study aims to determine the serum vitamin B-12 in children presenting with vasovagal syncope. METHODS AND STUDY DESIGN: This is a prospective review of 160 children presenting with vasovagal syncope. Subgroup analysis was done based on the results of head up tilt test. RESULTS: Head up tilt test gave positive results in 80 children and yielded negative results in the remaining 80 children. The tilt test positive children had significantly lower thyroid stimulating hormone concentrations (p=0...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29222266/impact-of-bone-disease-and-pain-in-thalassemia
#17
REVIEW
Antonio Piga
Conventional treatment of thalassemia, namely regular blood transfusion and iron chelation, improves perspectives and quality of life; however, successful treatment leads to more time in which long-term complications such as bone disease can develop. Thalassemia bone disease (TBD) is unique: all aspects, from bone anatomy and bone quality to mineral density, may be affected, with important morbidity including osteoporosis, fractures, spinal deformities, nerve compression, and pain. Clinical presentations include growth impairment, rickets-like features, back pain, spinal deformities, any sign of nerve compression, severe osteoporosis, and fragility fractures...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29221945/the-relationship-of-physical-performance-and-osteoporosis-prevention-with-vitamin-d-in-older-african-americans-poda
#18
Ruban Dhaliwal, Mageda Mikhail, Gianina Usera, Alexandra Stolberg, Shahidul Islam, Louis Ragolia, John F Aloia
RATIONALE: Vitamin D deficiency is associated with bone loss, poor muscle strength, falls and fracture. This information in older African Americans (AAs) is sparse. OBJECTIVE: The study of the relationship of Physical performance, Osteoporosis prevention with vitamin D in older African Americans (PODA) is a randomized, double-blind, placebo-controlled 3-year trial examining the effect of vitamin D on bone loss and physical performance in older AA women. METHODS: 260 healthy AA women aged >60years were assigned to receive placebo or vitamin D3...
December 5, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29220424/genetically-deprived-vitamin-d-exposure-predisposes-to-atrial-fibrillation
#19
Yap-Hang Chan, Kai-Hang Yiu, Jo Jo Hai, Pak-Hei Chan, Tai-Hing Lam, Ben J Cowling, Pak-Chung Sham, Chu-Pak Lau, Karen Siu-Ling Lam, Chung-Wah Siu, Hung-Fat Tse
Aims: Low vitamin D level is associated with atrial fibrillation (AF) and may be implicated in its pathogenesis. Methods and results: We studied single nucleotide polymorphisms (SNPs) of vitamin D mechanistic pathways and serum 25-hydroxyvitamin D [25(OH)D] levels in an age- and gender-matched case-control study (controls without AF: mean age 68.6 ± 8.7 years, female 25%; n = 1019; with AF: mean age 69.7 ± 9.5 years, female 30%; n = 156) recruited from a Chinese clinical cohort of patients with stable coronary artery disease...
December 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29218905/considerations-for-automated-machine-learning-in-clinical-metabolic-profiling-altered-homocysteine-plasma-concentration-associated-with-metformin-exposure
#20
Alena Orlenko, Jason H Moore, Patryk Orzechowski, Randal S Olson, Junmei Cairns, Pedro J Caraballo, Richard M Weinshilboum, Liewei Wang, Matthew K Breitenstein
With the maturation of metabolomics science and proliferation of biobanks, clinical metabolic profiling is an increasingly opportunistic frontier for advancing translational clinical research. Automated Machine Learning (AutoML) approaches provide exciting opportunity to guide feature selection in agnostic metabolic profiling endeavors, where potentially thousands of independent data points must be evaluated. In previous research, AutoML using high-dimensional data of varying types has been demonstrably robust, outperforming traditional approaches...
2018: Pacific Symposium on Biocomputing
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