Helena Libalova, Tana Zavodna, Fatima Elzeinova, Hana Barosova, Tereza Cervena, Alena Milcova, Jolana Vankova, Foteini Paradeisi, Michal Vojtisek-Lom, Jitka Sikorova, Jan Topinka, Pavel Rossner
Emissions from modern gasoline engines represent an environmental and health risk. In this study, we aimed to compare the toxicity of organic compound mixtures extracted from particulate matter (PM extracts) produced by neat gasoline (E0) and a blend containing 15% ethanol (E15), which is offered as an alternative to non-renewable fossil fuels. Human lung BEAS-2B cells were exposed to PM extracts, and biomarkers of genotoxicity, such as DNA damage evaluated by comet assay, micronuclei formation, levels of phosphorylated histone H2AX, the expression of genes relevant to the DNA damage response, and exposure to polycyclic aromatic hydrocarbons (PAHs), were determined...
December 21, 2023: Journal of Xenobiotics