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https://www.readbyqxmd.com/read/27874271/diagnostic-model-generated-by-mri-derived-brain-features-in-toddlers-with-autism-spectrum-disorder
#1
Xiang Xiao, Hui Fang, Jiansheng Wu, ChaoYong Xiao, Ting Xiao, Lu Qian, FengJing Liang, Zhou Xiao, Kang Kang Chu, Xiaoyan Ke
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with core symptoms of atypical social interaction, communication, and restricted, repetitive patterns of behavior, interests, and activities. Although the pathophysiologic mechanism of ASD is unclarified yet, the neuroanatomical features are considered as valuable predictors for discriminating ASD from others. But there has been relatively little scientific study about predictive power of different neuroanatomical features of early age ASD...
November 22, 2016: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/27855311/effect-of-aging-on-regional-neuromuscular-regulation-within-human-rectus-femoris-muscle-during-stair-ascent-and-descent
#2
Kohei Watanabe, Motoki Kouzaki, Toshio Moritani
Our recent studies showed the rectus femoris (RF) muscle is regionally regulated during the level walking and this unique neuromuscular activation pattern is influenced by aging (Watanabe et al., 2014, 2016 J Biomech). We aimed to investigate and compare regional neuromuscular activation patterns along the RF muscle between the young and elderly during the stair walking. Fourteen young men (age: 20.4±1.0years) and 14 elderly men (age: 73.8±5.9years) performed the stair ascent and descent. Fifteen trials of three steps were performed for both stair ascent and descent...
November 10, 2016: Gait & Posture
https://www.readbyqxmd.com/read/27852279/classification-of-parkinson-s-disease-utilizing-multi-edit-nearest-neighbor-and-ensemble-learning-algorithms-with-speech-samples
#3
He-Hua Zhang, Liuyang Yang, Yuchuan Liu, Pin Wang, Jun Yin, Yongming Li, Mingguo Qiu, Xueru Zhu, Fang Yan
BACKGROUND: The use of speech based data in the classification of Parkinson disease (PD) has been shown to provide an effect, non-invasive mode of classification in recent years. Thus, there has been an increased interest in speech pattern analysis methods applicable to Parkinsonism for building predictive tele-diagnosis and tele-monitoring models. One of the obstacles in optimizing classifications is to reduce noise within the collected speech samples, thus ensuring better classification accuracy and stability...
November 16, 2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/27844014/genetic-va-riation-in-the-na-rrow-c-lawed-c-ra-yfish-astacus-lepto-dactylus-po-pulatio-ns-as-assesse-d-by-pcr-rflp-of-mitochondria-l-coi-gene
#4
Majidreza Khos Hkholgh, Sajad Nazari
The genetic variation and population structure of narrow-clawed crayfish (Astacus leptodactylus) was examined by means of polymerase chain reaction (PC R) restriction fragment length polymorphism (RF LP) analysis of the cytochrome oxidase subunit I (COI) of mitochondrial DNA. A total of 194 adult specimens were collected from seven sample sites including, two in the south Caspian Sea and one each in Anzali wetland and Aras reservoir and three rivers Chafrood, Masule Rudkhan and S iah Darvishan. The PCR products were digested with 19 restriction enzymes and five enzymes revealed polymorphism patterns (DdeІ, MboІ, TaqI, RsaІ and HinfІ)...
December 2015: Molecular Biology Research Communications
https://www.readbyqxmd.com/read/27828194/reference-free-holographic-diversity-interferometry-via-iterative-measurements-for-high-accuracy-phase-detection
#5
Yuta Goto, Atsushi Okamoto, Yuta Wakayama, Kazuhisa Ogawa, Jin Nozawa, Akihisa Tomita, Takehiro Tsuritani
To obtain a phase distribution without the use of an optical path besides an object beam, a reference-free holographic diversity interferometry (RF-HDI) has been proposed. Although the RF-HDI can generate an internal reference beam from the object beam, the method has a problem of measurement accuracy due to insufficient power of the internal reference beam. To solve the problem, we newly propose a RF-HDI via iterative measurements. Our method improves the measurement accuracy by utilizing iterative measurements and feedback of each obtained phase image to the measurement system...
October 17, 2016: Optics Express
https://www.readbyqxmd.com/read/27827833/a-stretchable-radio-frequency-strain-sensor-using-screen-printing-technology
#6
Heijun Jeong, Sungjoon Lim
In this paper, we propose a stretchable radio-frequency (RF) strain sensor fabricated with screen printing technology. The RF sensor is designed using a half-wavelength patch that resonates at 3.7 GHz. The resonant frequency is determined by the length of the patch, and it therefore changes when the patch is stretched. Polydimethylsiloxane (PDMS) is used to create the substrate, because of its stretchable and screen-printable surface. In addition, Dupont PE872 (Dupont, NC, American) silver conductive ink is used to create the stretchable conductive patterns...
November 2, 2016: Sensors
https://www.readbyqxmd.com/read/27825072/surface-emg-analysis-for-the-quantification-of-thigh-muscle-dynamic-co-contractions-during-normal-gait
#7
Annachiara Strazza, Alessandro Mengarelli, Sandro Fioretti, Laura Burattini, Valentina Agostini, Marco Knaflitz, Francesco Di Nardo
The research purpose was to quantify the co-contraction patterns of quadriceps femoris (QF) vs. hamstring muscles during free walking, in terms of onset-offset muscular activation, excitation intensity, and occurrence frequency. Statistical gait analysis was performed on surface-EMG signals from vastus lateralis (VL), rectus femoris (RF), and medial hamstrings (MH), in 16315 strides walked by 30 healthy young adults. Results showed full superimpositions of MH with both VL and RF activity from terminal swing, 80 to 100% of gait cycle (GC), to the successive loading response (≈0-15% of GC), in around 90% of the considered strides...
November 2, 2016: Gait & Posture
https://www.readbyqxmd.com/read/27821150/comparative-effectiveness-of-treatment-with-the-first-tnf-antagonist-in-monotherapy-the-first-tnf-antagonist-plus-one-conventional-synthetic-disease-modifying-antirheumatic-drug-and-the-first-tnf-antagonist-plus-two-or-more-conventional-synthetic-disease-modifying
#8
Blanca Hernández-Cruz, Esther Márquez-Saavedra, Rafael Caliz-Caliz, Federico Navarro-Sarabia
BACKGROUND: Rheumatoid arthritis (RA) patients are treated with a mean of 3-4 conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) with or without glucocorticoids (GCs), before the first biologic prescription. The main reasons for change are inefficacy in 30-40 % of patients, and toxicity ≈ 10 %. Thus, they are treated with the first TNF antagonists in monotherapy. The aim of this study was to analyse the csDMARD and GC prescription patterns before and during treatment with the first TNF antagonist, and compare their effectiveness in three groups of patients...
November 8, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27818924/identification-and-differentiation-of-panax-ginseng-panax-quinquefolium-and-panax-notoginseng-by-monitoring-multiple-diagnostic-chemical-markers
#9
Wenzhi Yang, Xue Qiao, Kai Li, Jingran Fan, Tao Bo, De-An Guo, Min Ye
To differentiate traditional Chinese medicines (TCM) derived from congeneric species in TCM compound preparations is usually challenging. The roots of Panax ginseng (PG), Panax quinquefolium (PQ) and Panax notoginseng (PN) are used as popular TCM. They contain similar triterpenoid saponins (ginsenosides) as the major bioactive constituents. Thus far, only a few chemical markers have been discovered to differentiate these three species. Herein we present a multiple marker detection approach to effectively differentiate the three Panax species, and to identify them in compound preparations...
November 2016: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/27798605/nanocavity-optomechanical-torque-magnetometry-and-radiofrequency-susceptometry
#10
Marcelo Wu, Nathanael L-Y Wu, Tayyaba Firdous, Fatemeh Fani Sani, Joseph E Losby, Mark R Freeman, Paul E Barclay
Nanophotonic optomechanical devices allow the observation of nanoscale vibrations with a sensitivity that has dramatically advanced the metrology of nanomechanical structures and has the potential to impact studies of nanoscale physical systems in a similar manner. Here we demonstrate this potential with a nanophotonic optomechanical torque magnetometer and radiofrequency (RF) magnetic susceptometer. Exquisite readout sensitivity provided by a nanocavity integrated within a torsional nanomechanical resonator enables observations of the unique net magnetization and RF-driven responses of single mesoscopic magnetic structures in ambient conditions...
October 31, 2016: Nature Nanotechnology
https://www.readbyqxmd.com/read/27795746/surface-micromachining-of-polydimethylsiloxane-for-microfluidics-applications
#11
Staci Hill, Weiyi Qian, Weiqiang Chen, Jianping Fu
Polydimethylsiloxane (PDMS) elastomer has emerged as one of the most frequently applied materials in microfluidics. However, precise and large-scale surface micromachining of PDMS remains challenging, limiting applications of PDMS for microfluidic structures with high-resolution features. Herein, surface patterning of PDMS was achieved using a simple yet effective method combining direct photolithography followed by reactive-ion etching (RIE). This method incorporated a unique step of using oxygen plasma to activate PDMS surfaces to a hydrophilic state, thereby enabling improved adhesion of photoresist on top of PDMS surfaces for subsequent photolithography...
September 2016: Biomicrofluidics
https://www.readbyqxmd.com/read/27795697/dependence-of-b1-and-b1-field-patterns-of-surface-coils-on-the-electrical-properties-of-the-sample-and-the-mr-operating-frequency
#12
Manushka V Vaidya, Christopher M Collins, Daniel K Sodickson, Ryan Brown, Graham C Wiggins, Riccardo Lattanzi
In high field MRI, the spatial distribution of the radiofrequency magnetic ( B1) field is usually affected by the presence of the sample. For hardware design and to aid interpretation of experimental results, it is important both to anticipate and to accurately simulate the behavior of these fields. Fields generated by a radiofrequency surface coil were simulated using dyadic Green's functions, or experimentally measured over a range of frequencies inside an object whose electrical properties were varied to illustrate a variety of transmit [Formula: see text] and receive [Formula: see text] field patterns...
February 2016: Concepts in Magnetic Resonance. Part B, Magnetic Resonance Engineering
https://www.readbyqxmd.com/read/27779779/direct-sar-mapping-by-thermoacoustic-imaging-a-feasibility-study
#13
Simone A Winkler, Paul A Picot, Michael M Thornton, Brian K Rutt
PURPOSE: To develop a new method capable of directly measuring specific absorption rate (SAR) deposited in tissue using the thermoacoustic signal induced by short radiofrequency (RF) pulse excitation. THEORY: A detailed model based on the thermoacoustic wave generation and propagation is presented. METHODS: We propose a new concept for direct measurement of SAR, to be used as a safety assessment/monitoring tool for MRI. The concept involves the use of short bursts of RF energy and the measurement of the resulting thermoacoustic excitation pattern by an array of ultrasound transducers, followed by image reconstruction to yield the 3D SAR distribution...
October 25, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27765067/rheumatoid-arthritis-antigens-homocitrulline-and-citrulline-are-generated-by-local-myeloperoxidase-and-peptidyl-arginine-deiminases-2-3-and-4-in-rheumatoid-nodule-and-synovial-tissue
#14
Sanna Turunen, Johanna Huhtakangas, Tomi Nousiainen, Maarit Valkealahti, Jukka Melkko, Juha Risteli, Petri Lehenkari
BACKGROUND: Seropositive rheumatoid arthritis (RA) is characterized by autoantibodies binding to citrullinated and homocitrullinated proteins. We wanted to study the expression patterns of these disease-associated protein forms and if the rheumatoid nodule and synovial tissue itself contain biologically active levels of citrullinating peptidyl arginine deiminases 2, 3 and 4 and homocitrullination-facilitating neutrophil enzyme myeloperoxidase. METHOD: Total of 195 synovial samples from metatarsal joints from five ACPA/RF-positive RA patients (n = 77), synovial samples from knees of eight seropositive RA (n = 60), seven seronegative RA (n = 33) and five osteoarthritis (n = 25) patients were analyzed for citrulline and homocitrulline contents using HPLC...
October 20, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27746079/mmp-12-and-timp-behavior-in-symptomatic-and-asymptomatic-critical-carotid-artery-stenosis
#15
Flavia Del Porto, Noemi Cifani, Maria Proietta, Danilo Toni, Maurizio Taurino
OBJECTIVE: The aim of this study was to evaluate the levels of matrix metalloproteinase-12 (MMP-12) and tissue inhibitors of metalloproteinases (TIMP)-1, TIMP-2, TIMP-3, and TIMP-4 in patients with symptomatic and asymptomatic critical carotid artery stenosis (CAS). METHODS: We enrolled 10 patients affected by symptomatic CAS within 12 hours from onset of stroke (S group) and 30 patients with asymptomatic CAS (CAS group); 31 patients matched for age, sex, and traditional cardiovascular risk factors were used as controls (RF group)...
October 13, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27718453/parental-reflective-functioning-among-mothers-with-eating-disorder-symptomatology
#16
Elizabeth Claydon, Stephanie Zerwas, Laura Callinan, Megan V Smith
OBJECTIVE: Reflective Functioning is a vital aspect of parental aptitude and its absence, especially in the presence of psychopathology, can impair attachment. This study sought to clarify the relationship of parental RF among mothers with eating disorder symptomatology. METHOD: We assessed 59 mothers for ED symptomatology using the Eating Disorder Examination Questionnaire (EDE-Q) and RF through the Parental Reflective Functioning Questionnaire (PRFQ). Bivariate and multivariate analyses compared PRFQ subscales between symptomatic and asymptomatic mothers, using a clinical cutoff score of 4 on the EDE-Q subscales...
December 2016: Eating Behaviors
https://www.readbyqxmd.com/read/27717541/the-efficacy-of-a-novel-saline-bipolar-radiofrequency-energy-instrument-for-arresting-ongoing-solid-and-non-solid-organ-hemorrhage-in-a-swine-model
#17
Chad G Ball, Andre Campbell, Sean C Grondin, Elijah Dixon
INTRODUCTION: Ongoing hemorrhage is often life threatening and can be challenging to stop in critically injured patients. Traditional techniques for addressing this issue include high voltage cautery (Bovie), topical hemostatic application, and the delivery of ignited argon gas. The goal of this study was to evaluate the efficacy of a novel energy device for arresting ongoing bleeding from both solid and non-solid organs within a swine model. METHODS: A novel instrument utilizing bipolar radiofrequency (RF) energy which acts to ignite/boil dripping saline from a small hand piece was employed to arrest ongoing hemorrhage from an escalating series of injuries in large male swine...
December 2016: Injury
https://www.readbyqxmd.com/read/27715316/using-the-research-domain-criteria-framework-to-explore-associations-between-mmpi-2-rf-constructs-and-physiological-variables-assessed-by-eye-tracker-technology
#18
David M McCord, Margaret C Achee, Elissa M Cannon, Tiffany M Harrop, William D Poynter
The National Institute of Mental Health has proposed a paradigm shift in the conceptualization of psychopathology, abandoning the traditional categorical model in favor of one based on hierarchically organized dimensional constructs (Insel et al., 2010 ). One explicit goal of this initiative, the Research Domain Criteria (RDoC) project, is to facilitate the incorporation of newly available neurobiologic variables into research on psychopathology. The Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF; Ben-Porath & Tellegen, 2008/2011 ) represents a similar paradigm shift, also adopting a hierarchical arrangement of dimensional constructs...
October 7, 2016: Journal of Personality Assessment
https://www.readbyqxmd.com/read/27705879/local-tumor-progression-patterns-after-radiofrequency-ablation-of-colorectal-cancer-liver-metastases
#19
Marc Napoleone, Ania Z Kielar, Rebecca Hibbert, Sameh Saif, Benjamin Y Kwan
PURPOSE: We aimed to evaluate patterns of local tumor progression (LTP) after radiofrequency ablation (RF ablation) of colorectal cancer liver metastases (CRCLM) and to highlight the percentage of LTP not attributable to lesion size or RF ablation procedure-related factors (heat sink or insufficient ablation margin). METHODS: CRCLM treated by RF ablation at a single tertiary care center from 2004-2012, with a minimum of six months of postprocedure follow-up, were included in this retrospective study...
November 2016: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/27690642/regulatory-t-cd4-cd25-lymphocytes-increase-in-symptomatic-carotid-artery-stenosis
#20
Flavia Del Porto, Noemi Cifani, Maria Proietta, Sara Perrotta, Raffaele Dito, Cira di Gioia, Raffaella Carletti, Luigi Rizzo, Gianluigi Orgera, Michele Rossi, Livia Ferri, Luigi Tritapepe, Maurizio Taurino
BACKGROUND: Atherosclerosis is a multifactorial disease characterized by an immune-inflammatory remodeling of the arterial wall. Tregs and Th17 subpopulations are detectable inside atherosclerotic plaque, however their behavior in symptomatic carotid artery stenosis (CAS) is not fully elucidated. The aim of this study was to evaluate Th17 and Tregs subsets and their ratio in patients affected by symptomatic and asymptomatic CAS. METHODS: 14 patients with symptomatic CAS (CAS-S group), 41 patients with asymptomatic CAS (CAS-A group), 32 subjects with traditional cardiovascular risk factors (RF group) and 10 healthy subjects (HS group) were enrolled...
October 3, 2016: Annals of Medicine
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