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https://www.readbyqxmd.com/read/29764945/a-mechanism-of-unidirectional-transformation-leading-to-antibiotic-resistance-occurs-within-nasopharyngeal-pneumococcal-biofilm-consortia
#1
Santiago M Lattar, Xueqing Wu, Jennifer Brophy, Fuminori Sakai, Keith P Klugman, Jorge E Vidal
Streptococcus pneumoniae acquires genes for resistance to antibiotics such as streptomycin (Str) or trimethoprim (Tmp) by recombination via transformation of DNA released by other pneumococci and closely related species. Using naturally transformable pneumococci, including strain D39 serotype 2 (S2) and TIGR4 (S4), we studied whether pneumococcal nasopharyngeal transformation was symmetrical, asymmetrical, or unidirectional. Incubation of S2Tet and S4Str in a bioreactor simulating the human nasopharynx led to the generation of SpnTet/Str recombinants...
May 15, 2018: MBio
https://www.readbyqxmd.com/read/29764244/kinetics-and-tissue-repair-process-following-fractional-bipolar-radiofrequency-treatment
#2
G Kokolakis, L von Eichel, M Ulrich, J Lademann, T Zuberbier, M A Hofmann
INTRODUCTION: Fractionated radiofrequency (RF) tissue tightening is an alternative method to fractionated laser treatment of skin wrinkling, laxity and acne scars, with reduced risk of scarring or persistent pigmentation. The aim of this study was to evaluate and quantify the wound healing process after RF treatment. MATERIALS AND METHODS: 12 patients were treated with a 64-pin fractional bipolar RF device with 60 mJ/pin applied energy. Confocal laser scanning microscopy (CLSM) examination was performed on day 1, day 2, day 7 and day 14 after treatment...
May 15, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29755663/the-ongoing-challenge-of-large-anal-cancers-prospective-long-term-outcomes-of-intensity-modulated-radiation-therapy-with-concurrent-chemotherapy
#3
Ali Hosni, Kathy Han, Lisa W Le, Jolie Ringash, James Brierley, Rebecca Wong, Robert Dinniwell, Anthony Brade, Laura A Dawson, Bernard J Cummings, Monika K Krzyzanowska, Eric X Chen, David Hedley, Jennifer Knox, Alexandra M Easson, Patricia Lindsay, Tim Craig, John Kim
Purpose: Patterns of failure and long term outcomes were prospectively evaluated following tumor factors-stratified radiation dose for anal/perianal cancer. Methods: Between 2008-2013, patients with anal/perianal squamous cell carcinoma were accrued to an institutional REB-approved prospective study. All patients were treated with image-guided intensity-modulated radiation therapy (IG-IMRT). Radiation dose selection (27-36 Gy for elective target, and 45-63 Gy for gross target) was based on tumor clinico-pathologic features...
April 17, 2018: Oncotarget
https://www.readbyqxmd.com/read/29751525/demonstration-of-a-speckle-based-sensing-with-pulse-doppler-radar-for-vibration-detection
#4
Nisan Ozana, Reuven Bauer, Koby Ashkenazy, Nissim Sasson, Ariel Schwarz, Amir Shemer, Zeev Zalevsky
In previous works, an optical technique for extraction and separation of remote static vibrations has been demonstrated. In this paper, we will describe an approach in which RF speckle movement is used to extract remote vibrations of a static target. The use of conventional radar Doppler methods is not suitable for detecting vibrations of static targets. In addition, the speckle method has an important advantage, in that it is able to detect vibrations at far greater distances than what is normally detected in classical optical methods...
May 3, 2018: Sensors
https://www.readbyqxmd.com/read/29751090/sex-dependent-and-sex-independent-muscle-activation-patterns-in-adult-gait-as-a-function-of-age
#5
Christopher A Bailey, Federica Corona, Giuseppina Pilloni, Micaela Porta, Maria Chiara Fastame, Paul Kenneth Hitchcott, Maria Pietronilla Penna, Massimiliano Pau, Julie N Côté
INTRODUCTION: Aging leads to poorer neuromuscular control that may impact mobility. However, the specific decades when these changes occur, and whether these time-based changes are sex-specific, are unclear. METHODS: Adults aged 20-82 years (N = 93, 51 females) walked six gait trials at their preferred speed over a 10-m platform. Electromyography (EMG) of the rectus femoris (RF), tibialis anterior (TA), and gastrocnemius lateralis (GL) were measured using wireless surface sensors...
May 8, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29732351/cancers-of-the-brain-and-cns-global-patterns-and-trends-in-incidence
#6
S M J Mortazavi, S A R Mortazavi, M Paknahad
Miranda-Filho et al. in their recently published paper entitled "Cancers of the brain and CNS: global patterns and trends in incidence" provided a global status report of the geographic and temporal variations in the incidence of brain and CNS cancers in different countries across continents worldwide. While the authors confirm the role of genetic risk factors and ionizing radiation exposures, they claimed that no firm conclusion could be drawn about the role of exposure to non-ionizing radiation...
March 2018: Journal of Biomedical Physics & Engineering
https://www.readbyqxmd.com/read/29720260/smoking-body-mass-index-disease-activity-and-the-risk-of-rapid-radiographic-progression-in-patients-with-early-rheumatoid-arthritis
#7
Emil Rydell, Kristina Forslind, Jan-Åke Nilsson, Lennart T H Jacobsson, Carl Turesson
BACKGROUND: Identification of risk factors for rapid joint destruction in early rheumatoid arthritis (RA) can be helpful for optimizing treatment, and improving our understanding of destructive arthritis and its mechanisms. The objective of this study was to investigate the relationship between early RA patient characteristics and subsequent rapid radiographic progression (RRP). METHODS: An inception cohort of patients with early RA (symptom duration < 12 months), recruited during 1995-2005 from a defined area (Malmö, Sweden), was investigated...
May 2, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29709495/morphological-changes-induced-by-intraprostatic-psa-based-vaccine-in-prostate-cancer-biopsies-phase-i-clinical-trial
#8
Maria J Merino, A Peter, Vanessa Moreno, Sara Gil, Jeffrey Schlom, James L Gulley
Immunotherapy is a novel treatment for many tumors including prostate cancer. Little is known about the histological changes in prostate biopsies caused by the prostatic-specific antigen (PSA)-based vaccine. This study evaluated the histopathological effects in prostate biopsies of recombinant fowlpox (rF) virus-based vaccine engineered to present the PSA and three costimulatory molecules (collectively labeled as PSA-TRICOM). This vaccine has shown that it can break tolerance of the PSA, and its administration directly into a tumor enables the affected tumor cells to act as antigen-presenting cells activating new T-cells, and broadening the immune response to recognize and kill tumor...
April 27, 2018: Human Pathology
https://www.readbyqxmd.com/read/29709461/different-biochemical-patterns-in-type-ii-and-type-iii-mixed-cryoglobulinemia-in-hcv-positive-patients
#9
Umberto Basile, Francesca Gulli, Laura Gragnani, Krizia Pocino, Cecilia Napodano, Luca Miele, Stefano Angelo Santini, Mariapaola Marino, Anna Linda Zignego, Gian Ludovico Rapaccini
BACKGROUND: Reversible cryoprecipitability of proteins is observed as a concomitant feature of immune complex formation. Mixed cryoglobulinemia (MC) is systemic vasculitis, associated with mixed IgM and IgG cryoglobulins (CGs) showing rheumatoid factor (RF) activity. It is frequently associated with hepatitis C virus (HCV). This study investigates the presence of IgG RF and anti-nuclear antibodies (ANA) in cryoprecipitates of patients with type III and type II MC, to understand the biochemical patterns associated with different types of MC to a greater degree...
April 4, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29680436/distal-muscle-activity-alterations-during-the-stance-phase-of-gait-in-restless-leg-syndrome-rls-patients
#10
Chloe Dafkin, Andrew Green, Benita Olivier, Warrick McKinon, Samantha Kerr
OBJECTIVE: To assess if there is a circadian variation in electromyographical (EMG) muscle activity during gait in restless legs syndrome (RLS) patients and healthy control participants. METHODS: Gait assessment was done in 14 RLS patients and 13 healthy control participants in the evening (PM) and the morning (AM). Muscle activity was recorded bilaterally from the tibialis anterior (TA), lateral gastrocnemius (GL), rectus femoris (RF) and biceps femoris (BF) muscles...
May 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29679219/rf-ablation-pattern-shaping-employing-switching-channels-of-dual-bipolar-needle-electrodes-ex-vivo-results
#11
Jens Ziegle, Chloé Audigier, Johannes Krug, Ghazanfar Ali, Younsu Kim, Emad M Boctor, Michael Friebe
PURPOSE: Radiofrequency (RF) ablation with mono- or bipolar electrodes is a common procedure for hepatocellular carcinoma (HCC) with a low rate of recurrence for small size tumors. For larger lesions and/or non-round/ellipsoid shapes RF ablation has some limitations and generally does not achieve comparable success rates to microwave ablation or high-intensity focused ultrasound therapies. MATERIALS AND METHODS: To shape RF ablations for matching a tumor size and geometry, we have developed an electronic channel switch box for two bipolar needles that generates multiple selectable ablation patterns...
April 20, 2018: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/29677777/a-study-on-the-formation-of-2-dimensional-tungsten-disulfide-thin-films-on-sapphire-substrate-by-sputtering-and-high-temperature-rapid-thermal-processing
#12
Hanyeob Nam, Hong-Seok Kim, Jae-Hee Han, Sang Jik Kwon, Eou Sik Cho
As direct formation of p-type two-dimensional transition metal dichalcogenides (TMDC) films on substrates, tungsten disulfide (WS2) thin films were deposited onto sapphire glass substrate through shadow mask patterns by radio-frequency (RF) sputtering at different sputtering powers ranging from 60 W to 150 W and annealed by rapid thermal processing (RTP) at various high temperatures ranging from 500 °C to 800 °C. Based on scanning electron microscope (SEM) images and Raman spectra, better surface roughness and mode dominant E12g and A1g peaks were found for WS2 thin films prepared at higher RF sputtering powers...
September 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29677664/age-induced-changes-in-the-lower-limb-muscle-activities-during-uphill-walking-at-steep-grades
#13
Sonja Th Kwee-Meier, Alexander Mertens, Sabina Jeschke
BACKGROUND: Uphill walking is particularly challenging for elderly persons. However, there is a lack of age-differentiated studies investigating the underlying differences in muscle activation when walking on sloped surfaces. These studies are needed, e.g., for planning of evacuations of large modern cruise ships with long walking distances on often inclined surfaces. METHODS: An age-differentiated, gender-balanced study with 26 young (20-30 years) and 26 elderly people (60-77 years) was therefore conducted, investigating uphill walking at 7° and at 14° contrasted to level walking on a treadmill...
April 12, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29670177/proton-decoupled-carbon-magnetic-resonance-spectroscopy-in-human-calf-muscles-at-7-t-using-a-multi-channel-radiofrequency-coil
#14
Sigrun Goluch, Roberta Frass-Kriegl, Martin Meyerspeer, Michael Pichler, Jürgen Sieg, Martin Gajdošík, Martin Krššák, Elmar Laistler
13 C magnetic resonance spectroscopy is a viable, non-invasive method to study cell metabolism in skeletal muscles. However, MR sensitivity of 13 C is inherently low, which can be overcome by applying a higher static magnetic field strength together with radiofrequency coil arrays instead of single loop coils or large volume coils, and 1 H decoupling, which leads to a simplified spectral pattern. 1 H-decoupled 13 C-MRS requires RF coils which support both, 1 H and 13 C, Larmor frequencies with sufficient electromagnetic isolation between the pathways of the two frequencies...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29665781/machine-learning-methods-reveal-the-temporal-pattern-of-dengue-incidence-using-meteorological-factors-in-metropolitan-manila-philippines
#15
Thaddeus M Carvajal, Katherine M Viacrusis, Lara Fides T Hernandez, Howell T Ho, Divina M Amalin, Kozo Watanabe
BACKGROUND: Several studies have applied ecological factors such as meteorological variables to develop models and accurately predict the temporal pattern of dengue incidence or occurrence. With the vast amount of studies that investigated this premise, the modeling approaches differ from each study and only use a single statistical technique. It raises the question of whether which technique would be robust and reliable. Hence, our study aims to compare the predictive accuracy of the temporal pattern of Dengue incidence in Metropolitan Manila as influenced by meteorological factors from four modeling techniques, (a) General Additive Modeling, (b) Seasonal Autoregressive Integrated Moving Average with exogenous variables (c) Random Forest and (d) Gradient Boosting...
April 17, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29623847/adenosine-deaminase-activity-and-hla-drb-as-diagnostic-markers-for-rheumatoid-arthritis
#16
Shirin Valadbeigi, Mina Ebrahimi-Rad, Shohreh Khatami, Hadi Akhbari, Reza Saghiri
BACKGROUND AND OBJECTIVE: Rheumatoid Arthritis (RA) is a chronic multi systemic disorder with the unclarified ethiopathology. Although several markers have been presented for recognition of RA, but none of them has been specific. New markers such as HLA typing and activity of Adenosine deaminase (ADA) isoenzymes could be useful and specific. The aim of this study is to evaluate the pattern of ADA isoenzymes activity and HLA typing in both RA patients and healthy cases. METHODS: Blood samples were collected from 55 RA patients and 60 healthy subjects, over a period of 6 months...
April 5, 2018: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/29617171/lenvatinib-induced-renal-failure-two-first-time-case-reports-and-review-of-literature
#17
Stefano Cavalieri, Laura Cosmai, Augusto Genderini, Manuela Nebuloni, Antonella Tosoni, Federica Favales, Paola Pistillo, Cristiana Bergamini, Paolo Bossi, Lisa Licitra, Laura D Locati, Salvatore Alfieri
Lenvatinib (LEN) is a multi-kinase anti-angiogenic drug recently approved in several cancers. LEN is not easily manageable due to its complex safety profile. Proteinuria and renal failure (RF) were reported among the most frequent LEN-induced adverse events (AEs), often leading to discontinuations or dose modifications. Understanding the pathogenesis of these AEs could ameliorate the management of LEN-induced renal toxicity. Areas covered: We present two cases of LEN-induced renal failure (LIRF) with different pathogenesis...
April 4, 2018: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/29607211/development-of-a-multisensory-wearable-system-for-monitoring-cigarette-smoking-behavior-in-free-living-conditions
#18
Masudul Haider Imtiaz, Raul I Ramos-Garcia, Volkan Yusuf Senyurek, Stephen Tiffany, Edward Sazonov
This paper presents the development and validation of a novel multi-sensory wearable system (Personal Automatic Cigarette Tracker v2 or PACT2.0) for monitoring of cigarette smoking in free-living conditions. The contributions of the PACT2.0 system are: (1) the implementation of a complete sensor suite for monitoring of all major behavioral manifestations of cigarette smoking (lighting events, hand-to-mouth gestures, and smoke inhalations); (2) a miniaturization of the sensor hardware to enable its applicability in naturalistic settings; and (3) an introduction of new sensor modalities that may provide additional insight into smoking behavior e...
December 2017: Electronics (Basel)
https://www.readbyqxmd.com/read/29607046/a-machine-learning-approach-for-extending-classical-wildlife-resource-selection-analyses
#19
Kevin T Shoemaker, Levi J Heffelfinger, Nathan J Jackson, Marcus E Blum, Tony Wasley, Kelley M Stewart
Resource selection functions (RSFs) are tremendously valuable for ecologists and resource managers because they quantify spatial patterns in resource utilization by wildlife, thereby facilitating identification of critical habitat areas and characterizing specific habitat features that are selected or avoided. RSFs discriminate between known-use resource units (e.g., telemetry locations) and available (or randomly selected) resource units based on an array of environmental features, and in their standard form are performed using logistic regression...
March 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29601012/photonics-enabled-wideband-microwave-burst-detection
#20
Yihan Li, Naoya Kuse, Martin Fermann
In this Letter, to the best of our knowledge, a novel wideband microwave burst detection system is realized by utilizing photonics-assisted wavelength and time division multiplexing, in conjunction with optical storage. Deploying a coherent electro-optical dual comb and a recirculating optical frequency shifter with ∼1.28  μs round-rip delay, the proof-of-concept experimental system demonstrates the interrogation of ∼1  μs radio frequency (RF) bursts with up to an 8 GHz bandwidth and arbitrary hopping pattern at 1 MHz resolution and a refresh rate of ∼60  kHz using an 80 MHz RF detection unit...
April 1, 2018: Optics Letters
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