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Trishan Patel, Amy Elphick, James E Jackson, Claire L Shovlin
OBJECTIVE: To evaluate if injection of intravenous particles may provoke migraines in subjects with right-to-left shunts due to pulmonary arteriovenous malformations (AVMs). BACKGROUND: Migraine headaches commonly affect people with hereditary hemorrhagic telangiectasia (HHT), especially those with pulmonary AVMs that provide right-to-left shunts. In our clinical practice, patients occasionally reported acute precipitation of migraine headaches following injection of technetium-labeled albumin macroaggregates for nuclear medicine scans...
October 11, 2016: Headache
Sally Mannix, Anne Skalicky, Dawn C Buse, Pooja Desai, Sandhya Sapra, Brian Ortmeier, Katherine Widnell, Asha Hareendran
BACKGROUND: Migraine is characterized by headache with symptoms such as intense pain, nausea, vomiting, photophobia, and phonophobia that significantly impact individuals' lives. The objective of this study was to develop a strategy to measure outcomes from the patients' perspectives for use in evaluating preventive treatments for migraine. METHODS: This study used a multi-stage process. The first stage included concept identification research through literature review, patient-reported outcome (PRO) instrument content review, and clinician interviews, and resulted in a list of concepts relevant to understand the migraine experience...
October 6, 2016: Health and Quality of Life Outcomes
Meeta Pathak, O K Olstad, Liv Drolsum, Morten C Moe, Natalia Smorodinova, Sarka Kalasova, Katerina Jirsova, Bjørn Nicolaissen, Agate Noer
Patients with limbal stem cell deficiency (LSCD) often experience pain and photophobia due to recurrent epithelial defects and chronic inflammation of the cornea. Successfully restoring a healthy corneal surface in these patients by transplantation of ex vivo expanded human limbal epithelial cells (LECs) may alleviate these symptoms and significantly improve their quality of life. The clinical outcome of transplantation is known to be influenced by the quality of transplanted cells. Presently, several different protocols for cultivation and transplantation of LECs are in use...
October 1, 2016: Experimental Eye Research
Darija Mahović, Fanika Mrsić
Dear Editor, the practitioners of traditional Chinese medicine described psoriasis some 2000 years ago (1). Psoriasis vulgaris is a common, chronic inflammatory skin disease whose worldwide prevalence ranges from 0.1-3% (2,3). Understanding the role of the immune system in psoriasis and the interplay between the innate and adaptive immune system has helped to manage this complex disease, which affects patients far beyond the skin changes themselves (2). In addition to the usual and widely accepted methods of treatment of psoriasis, including topical therapies, phototherapy, and conventional and biological systemic therapies, data can be found in the literature that suggest a favorable effect of acupuncture on the course of psoriasis (4,5)...
August 2016: Acta Dermatovenerologica Croatica: ADC
Maya Kumar, Sheila Gahagan, Bretten Pickering, Jeffrey Gold, Martin T Stein
Jennifer is a 16-year-old Latina girl who is new to your practice. During her first well visit, she mentions that she has had daily headaches for 2 years. They began after sustaining a concussion in a car accident. Typically, her headaches are bilateral and "squeezing"; they occur in the afternoons and last for a few hours. Her concussion also resulted in depressed mood, which has improved over time.When you ask if her headaches have changed recently, she says that they have been worse for the last few days...
September 20, 2016: Journal of Developmental and Behavioral Pediatrics: JDBP
Sara AlQuorain, Sukayna Alfaraj, Mohammed Alshahrani
A 45-year-old woman presented to the Emergency Department complaining of severe headache for 3 hours duration associated with bilateral blurred vision, photophobia, and one attack of vomiting. Her clinical examination revealed normal vital signs and decrease in visual acuity with hazy cornea bilaterally. There were no signs of increased intracranial pressure and no neck rigidity or meningeal signs. The patient was diagnosed with bilateral acute closed angle glaucoma (AACG) with intraocular pressure of 60 mmHg in both eyes...
2016: Open Access Emergency Medicine: OAEM
Sheena Sharma, Jennifer M Kalish, Ethan M Goldberg, Francis Jeshira Reynoso, Madhura Pradhan
Background. Oral-facial-digital syndrome type 1 (OFD1) is a rare condition with X-linked dominant inheritance caused by mutations in the Cxorf5 (OFD1) gene. This gene encodes the OFD1 protein located within centrosomes and basal bodies of primary cilia. Approximately 15-50% of patients with OFD1 progress to end-stage kidney disease following development of polycystic changes within the kidneys. This condition almost always causes intrauterine lethality in males. Description of Case Diagnosis and Treatment. A Caucasian male aged 9 years and 9 months presented with increased urinary frequency, increased thirst, and decreased appetite...
2016: Case Reports in Nephrology
Muhammad Saim Khan, Imran Basit, Mazhar Ishaq, Tariq Shakoor, Amer Yaqub, Rana Intisar
OBJECTIVE: To determine mean change in visual acuity, central corneal thickness and symptoms in patients with pseudophakic bullous keratopathy after treatment with corneal collagen crosslinking. METHODS: This quasi experimental study was conducted at Armed Forces Institute of Ophthalmology, Rawalpindi, Pakistan from April 2015 to Nov 2015. A total of 24 eyes of 24 patients were included in the study. Visual symptoms were graded in five grades (Grade 1-5), Grade-1 being very mild with decreased vision only while patients with all five symptoms (decreased vision, foreign body sensations, pain, watering and photophobia) were graded as Grade-5...
July 2016: Pakistan Journal of Medical Sciences Quarterly
Ana L Pérez-Balbuena, Juan C Ochoa-Tabares, Sandra Belalcazar-Rey, Cristian Urzúa-Salinas, Laura R Saucedo-Rodríguez, Regina Velasco-Ramos, Raúl G Suárez-Sánchez, Adolfo D Rodríguez-Carrizalez, Aldo A Oregón-Miranda
BACKGROUND: Dry eye disease (DED) is multifactorial, affecting 5-34 % of the global adult population and reducing quality of life. The artificial tears or lubricants are the therapy most used for the treatment of DED, due to their low side effect profile, which attempt to modify the properties of the tear film. The aim of the present study was to evaluate the clinical efficacy of a fixed combination of xanthan gum and chondroitin sulfate preservative free on the ocular surface of patients with dry eye disease during 60 days of intervention...
2016: BMC Ophthalmology
Doga Vuralli, H Evren Boran, Bulent Cengiz, Ozlem Coskun, Hayrunnisa Bolay
BACKGROUND AND OBJECTIVE: Migraine headache attacks have been shown to be accompanied by significant prolongation of somatosensory temporal discrimination threshold values, supporting signs of disrupted sensorial processing in migraine. Chronic migraine is one of the most debilitating and challenging headache disorders with no available biomarker. We aimed to test the diagnostic value of somatosensory temporal discrimination for chronic migraine in this prospective, controlled study. METHODS: Fifteen chronic migraine patients and 15 healthy controls completed the study...
October 2016: Headache
Pawan Prasher, Mandeep Kaur, Shakeen Singh, Harpreet Kaur, Madhu Bala, Silonie Sachdeva
PURPOSE: To report the pattern of ophthalmic manifestations associated with Paederus dermatitis (PD). SETTING: Department of Ophthalmology, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, India. DESIGN: Clinic-based retrospective study. METHODS: Medical charts of patients presenting to the eye clinic with clinical features consistent with the diagnosis of PD from May 1, 2014 to April 30, 2016 were retrospectively reviewed...
September 15, 2016: International Ophthalmology
Stefânia Barbosa Diniz de Vasconcelos, Fernanda Machado Guerra, Gisele Macioca Morato, Nathália Teles das Neves, Patrick Frensel Tzelikis
We describe an unusual case of acquired anterior staphyloma in a patient addicted to crack cocaine. At the beginning of his crack cocaine abuse, he noticed redness and irritation of his eyes. Over the next 4 months, the patient also noticed the onset of decreasing visual acuity in his right eye (OD). Initially, his visual acuity was light perception in OD, and slit-lamp examination revealed a corneal infiltrate with a peripheral perforation and an iris prolapse. The patient was hospitalized to ensure compliance with the prescribed treatment and was advised to undergo therapeutic keratoplasty; however, the patient left the hospital against medical advice and was lost to follow-up for the next 6 months...
July 2016: Arquivos Brasileiros de Oftalmologia
Alessandro Lambiase, Benjamin D Sullivan, Tannin A Schmidt, David A Sullivan, Gregory Jay, Edward R Truitt, Alice Bruscolini, Marta Sacchetti, Flavio Mantelli
PURPOSE: The objective of this clinical trial (NCT02507934) was to assess the efficacy and safety of recombinant human lubricin as compared to a 0.18% sodium hyaluronate (HA) eye drop in subjects with moderate dry eye disease (DED). METHODS: DEWS Grade 2-3 subjects were randomized to use lubricin (N=19, 51.9±11.8 years) or HA (N=20, 61.8±13.3 years). After a saline washout period, subjects administered BID therapy for 7 days, followed by instillation as needed (2-6 drops per eye) for 7 days...
September 7, 2016: Ocular Surface
Evangelos Anagnostou, Michael Vikelis, Elias Tzavellas, Apostolia Ghika, Ioanna Kouzi, Ioannis Evdokimidis, Evangelia Kararizou
OBJECTIVES: Although photophobia is a well-known symptom in various disorders, it has rarely been studied explicitly and its definition in a clinical setting can be somewhat elusive. Here, we assessed photophobia with a common psychometric tool in different conditions, in which light intolerance is considered part of the syndrome. PATIENTS AND METHODS: A prospective study was undertaken in patients with migraine (MH), cluster headache (CH), tension-type headache (TH), essential blepharospasm (BS) and major depression (MD)...
August 31, 2016: International Journal of Neuroscience
Sanjeet K Shahi
Acute retinal necrosis (ARN), secondary to herpes simplex encephalitis, is a rare syndrome that can present in healthy individuals, as well as immuno-compromised patients. Most cases are caused by a secondary infection from the herpes virus family, with varicella zoster virus being the leading cause of this syndrome. Potential symptoms include blurry vision, floaters, ocular pain and photophobia. Ocular findings may consist of severe uveitis, retinal vasculitis, retinal necrosis, papillitis and retinal detachment...
August 31, 2016: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
Duriye Deniz Demirseren, Fadime Kilinc, Selma Emre, Mesut Akyol, Ahmet Metin, Akin Aktas
BACKGROUND: The purpose of our study is to find out in which weeks and in which cumulative doses the side effects emerge and to study whether or not there is a significant variance between the observed period and doses of the emergent side effects of the patients taking the daily doses of below and above 0.5 mg/kg. METHODS: Patients were started treatment with doses of 0.25-1 mg/kg isotretinoin, and a form was given to the patients to mark which probable side effects occurred in which weeks and called for weekly follow-up for the first 2 months...
September 15, 2016: Journal of Dermatological Treatment
Laura Moyal, Olivia Zambrowski, Charles Thirkill, Caroline Bottin, Rocio Blanco, Corinne Haioun, Eric H Souied
PURPOSE: To report the case of a patient whose retinal disease was found to be associated with a diffuse large B-cell lymphoma found 30 years after the apparent successful treatment of a classical Hodgkin lymphoma. METHODS: Observational case report. RESULTS: The authors describe the case of a 69-year-old man referred to their Department because of progressive, bilateral vision loss over the last few months. Deterioration in color vision and intense photophobia were also present...
August 26, 2016: Retinal Cases & Brief Reports
Leilei Zhang, Jie He, Bing Han, Linna Lu, Jiayan Fan, He Zhang, Shengfang Ge, Yixiong Zhou, Renbing Jia, Xianqun Fan
Distichiasis presents as double rows of eyelashes arising from aberrant differentiation of the meibomian glands of the eyelids, and it may be sporadic or hereditary. FOXC2 gene mutations in hereditary distichiasis are rarely reported. Here, we examined two generations of a Chinese family with hereditary distichiasis but without lymphedema or other features of LD syndrome. The FOXC2 gene was amplified and sequenced in all family members. Subcellular localization and luciferase assays were performed to assess the activity of the mutant FOXC2 protein...
2016: International Journal of Biological Sciences
Gréta Varkoly, János Bencze, László Módis, Tibor Hortobágyi
The human cornea is rich in extracellular matrix. The stroma constitutes the main thickness of the cornea, which consists of collagens and proteoglycans mainly. The epithelial-stromal and stromal dystrophies of the cornea are either autosomal dominant or recessive inherited disorders, which are unrelated to inflammation or trauma. The diseases can manifest in each layer of the cornea, but in most cases the corneal stroma is affected. Generally, they develop in childhood or young adulthood but the diagnosis is only possible when clinical signs (epithelial erosions, decreased visual acuity, photophobia) develop...
August 2016: Orvosi Hetilap
Kristian Thorlund, Kabirraaj Toor, Ping Wu, Keith Chan, Eric Druyts, Elodie Ramos, Rahul Bhambri, Anne Donnet, Richard Stark, Peter J Goadsby
INTRODUCTION: Migraine headache is a neurological disorder whose attacks are associated with nausea, vomiting, photophobia and phonophobia. Treatments for migraine aim to either prevent attacks before they have started or relieve attacks (abort) after onset of symptoms and range from complementary therapies to pharmacological interventions. A number of treatment-related adverse events such as somnolence, fatigue, and chest discomfort have previously been reported in association with triptans...
August 12, 2016: Cephalalgia: An International Journal of Headache
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