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https://www.readbyqxmd.com/read/29137026/implantation-of-artificialiris-a-customflex-irisprosthesis-in-a-trauma-patient-with-an-artisan-lens-a-case-report-and-review
#1
Farideh Doroodgar, Mahmoud Jabbarvand, Feizollah Niazi, Sana Niazi, Azad Sanginabadi
PURPOSE: To evaluate probable complications of ArtificialIris implantation with iris fixated intraocular lens. METHOD: Development of photophobia, glare, and psychological strain during face-to-face communication in a 23-year-old man with a widespread traumatic iris defect terminate to make a decision for performing implantation of an ArtificialIris (Humanoptics, Erlangen, Germany) under the remnant iris without removing the patient's existing Artisan lens. RESULTS: Without any intraoperative or postoperative complications, the patient's visual acuity increased by 1 line, the endothelial cell loss was comparable with the cell loss associated with standard cataract surgery, and the anterior-chamber depth and anterior-chamber anatomy did not change...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29135704/popper-maculopathy-long-term-follow-up-and-case-series
#2
Michelle Hui, Justin Galvin, Michael Chilov, Pierre-Henry Gabrielle, Adrian T Fung
PURPOSE: To report a case series of popper maculopathy. METHODS: Clinical history, examination findings, retinal imaging, and progress of the disease are described. RESULTS: Four male patients with a mean age of 37 years (range 25-48) and different duration of popper use (ranging from first time user to chronic user) presented with central scotomata, phosphenes, or photophobia. Optical coherence tomography in all cases demonstrated subfoveal disruption of the ellipsoid zone...
November 10, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29118500/iridoplasty-of-fixed-dilated-pupil-urrets-zavalia-syndrome-after-deep-anterior-lamellar-keratoplasty
#3
Efthalia Ntora, Nikolaos Ziakas
A 38-year-old woman with advanced keratoconus initially developed Urrets-Zavalia Syndrome (UZS) in the left eye after deep anterior lamellar keratoplasty. During the uneventful surgery, a 7-mm-wide pupil unresponsive to light was noticed. On the first postoperative day, intraocular pressure (IOP) was elevated up to 45 mmHg with shallow anterior chamber (AC). A peripheral iridotomy in 2 o'clock position was conducted and a fixed combination of brinzolamide 1% and timolol 0.5% was administered topically. In the subsequent postoperative period, IOP was successfully reduced, but the patient reported severe photophobia, glare, and decreased vision...
September 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/29114288/lhermitte-duclos-disease-a-rare-cause-of-cerebellar-ataxia
#4
Sanjay Pandey, Neelav Sarma
The aim of this study is to describe a case of Lhermitte-Duclos disease (LDD), which is an extremely rare cause of cerebellar ataxia. LDD is an extremely rare type of benign cerebellar mass and usually manifest as features of raised intracranial pressure and cerebellar dysfunction. Patients may remain asymptomatic for many years, and detection of tumor may be by chance on routine magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS). A 29-year-old female presented to the outdoor patient department with 18 months history of a headache, which was moderate to severe in intensity, throbbing in nature, localized to the right side of the head, and associated with nausea and photophobia...
October 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29110944/botulinum-toxin-a-for-the-treatment-of-photophobia-and-dry-eye
#5
Ryan J Diel, Zachary A Kroeger, Roy C Levitt, Constantine Sarantopoulos, Heather Sered, Jasmine Martinez-Barrizonte, Anat Galor
No abstract text is available yet for this article.
October 27, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29101724/adjunctive-role-of-self-retained-cryopreserved-amniotic-membrane-in-treating-immune-related-dry-eye-disease
#6
Anny M S Cheng, Sean Tighe, Hosam Sheha, Scheffer C G Tseng
PURPOSE: To present a case of successful treatment of immune-related severe dry eye disease (DED) by self-retained cryopreserved amniotic membrane (CAM) in conjunction with conventional and systemic immunotherapy. OBSERVATIONS: A 48-year-old female with a 10-year history of rheumatoid arthritis under systemic immunomodulation developed non-resolved severe ocular dryness, pain, photophobia and blurred vision due to corneal epithelial keratopathy OD much worse than OS despite topical artificial tears, steroids, cyclosporine, autologous serum drops, punctal plugs and scleral lens for the last 3 years...
November 3, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29096522/phenotypic-and-treatment-outcome-data-on-sunct-and-suna-including-a-randomised-placebo-controlled-trial
#7
Hsing-Yu Weng, Anna S Cohen, Christoph Schankin, Peter J Goadsby
Background Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) and short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms (SUNA) are two rare headache syndromes classified broadly as Trigeminal Autonomic Cephalalgias (TACs). Methods Here, 65 SUNCT (37 males) and 37 SUNA (18 males) patients were studied to describe their clinical manifestations and responses to treatment. Results Pain was almost always unilateral and side-locked...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29075855/efficacy-of-depatuxizumab-mafodotin-abt-414-monotherapy-in-patients-with-egfr-amplified-recurrent-glioblastoma-results-from-a-multi-center-international-study
#8
Martin van den Bent, Hui K Gan, Andrew B Lassman, Priya Kumthekar, Ryan Merrell, Nicholas Butowski, Zarnie Lwin, Tom Mikkelsen, Louis B Nabors, Kyriakos P Papadopoulos, Marta Penas-Prado, John Simes, Helen Wheeler, Tobias Walbert, Andrew M Scott, Erica Gomez, Ho-Jin Lee, Lisa Roberts-Rapp, Hao Xiong, Earle Bain, Peter J Ansell, Kyle D Holen, David Maag, David A Reardon
PURPOSE: Patients with recurrent glioblastoma (rGBM) have a poor prognosis. Epidermal growth factor receptor (EGFR) gene amplification is present in ~ 50% of glioblastomas (GBMs). Depatuxizumab mafodotin (depatux-m), formerly ABT-414, is an antibody-drug conjugate that preferentially binds cells with EGFR amplification, is internalized and releases a potent antimicrotubule agent, monomethyl auristatin F (MMAF). Here we report the safety, pharmacokinetics, and efficacy of depatux-m monotherapy at the recommended Phase 2 dose (RPTD) in patients with EGFR-amplified, rGBM...
October 26, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29070018/hemorrhagic-hypopyon-as-presenting-feature-of-intravascular-lymphoma-a-case-report
#9
Andrew Winegarner, Noriyasu Hashida, Shizuka Koh, Kohji Nishida
BACKGROUND: Herpes uveitis has been previously reported to present with hyphema, but hemorrhagic hypopyon is rarely reported as a herpetic uveitis manifestation. We report a case of herpes simplex virus (HSV) presenting with hemorrhagic hypopyon, and speculate on the underlying pathophysiology with relation to an intravascular lymphoma which was subsequently diagnosed as a result. CASE PRESENTATION: We present a case wherein a 62-year-old Japanese rheumatoid arthritis woman, with HSV uveitis, presented with hemorrhagic hypopyon in the anterior chamber and a fever with photophobia...
October 25, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29068979/trabeculotomy-ab-interno-with-trabectome-as-surgical-management-for-systemic-fluoroquinolone-induced-pigmentary-glaucoma-a-case-report
#10
Kyle A Den Beste, Constance Okeke
RATIONALE: Bilateral acute iris transillumination (BAIT) is a poorly-understood ocular syndrome in which patients present with acute iridocyclitis and pigmentary dispersion with or without ocular hypertension. The etiology of the disease remains unknown, though recent reports suggest an antecedent upper respiratory tract infection or systemic antibiotic administration may trigger the clinical syndrome. PATIENT CONCERNS: A 55-year-old female was referred for a second opinion regarding her bilateral ocular pain, photophobia, and ocular hypertension...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29047014/a-callosal-catastrophe-toxic-leukoencephalopathy-associated-with-thermogenic-weight-loss-supplement-use
#11
Zakraus K Mahdavi, Ram Narayan, Shraddha Mainali, Benjamin M Greenberg, Venkatesh Aiyagari, David L McDonagh
BACKGROUND: The use of weight loss drugs and dietary supplements is common, but safety profiles for these drugs are largely unknown. Reports of toxicity have been published, and the use of these agents should be considered in clinical differential diagnoses. METHODS: We report the case of a patient with toxic leukoencephalopathy and hyponatremia associated with oral consumption of a thermogenic dietary supplement and essential oils. RESULTS: A 30-year-old woman presented after 2 days of headache, blurred vision, photophobia, vomiting, and hand spasms...
October 18, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/29044077/ophthalmic-manifestations-in-rothmund-thomson-syndrome-case-report-and-review-of-literature
#12
J T Chinmayee, G R Meghana, R K Prathiba, T K Ramesh
A 24-year-old male patient presented to us with diminution of vision in both eyes with watering and photophobia for the past 8 years. General physical examination showed short stature and poikiloderma. Ocular findings include photophobia with reflex tearing, dry eye, cicatricial ectropion, symblepharon approaching pupillary area of cornea, and multiple superficial punctuate erosions on the cornea. Both eyelids showed scanty meibomian glands on infrared meibography. The rest of the anterior and posterior segment was normal...
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29034154/intraocular-pressure-monitoring-by-rebound-tonometry-in-children-with-myopia
#13
Jenchieh Weng, I-Lun Tsai, Li-Lin Kuo, Ching-Yao Tsai, Lin-Chung Woung, Ya-Chuan Hsiao
BACKGROUND/PURPOSE: Topical atropine treatment is generally accepted to retard the progression of myopia, but it is associated with side effects such as photophobia and elevation of intraocular pressure (IOP). IOP measurements in children are challenging. The traditional applanation tonometry by direct contact with the cornea will require patient's cooperation. The rebound tonometer, using a dynamic electromechanical method for measuring IOP, shows good correlation with traditional tonometry...
July 2017: Taiwan Journal of Ophthalmology
https://www.readbyqxmd.com/read/29033539/possible-association-between-subtypes-of-dry-eye-disease-and-seasonal-variation
#14
Masahiko Ayaki, Motoko Kawashima, Miki Uchino, Kazuo Tsubota, Kazuno Negishi
PURPOSE: The purpose of this study was to evaluate the influence of seasons on the signs and symptoms of dry eye disease (DED). METHODS: This is a cross-sectional, case-control study, and participants were non-DED subjects (n=1,916, mean age 54.4±14.4 years) and DED patients (n=684, 54.2±12.1 years) visiting six eye clinics at various practices and locations in Japan. We evaluated the signs and symptoms of DED and the seasons with the most severe results were compared to those with the least severe results in both groups...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29023238/severe-phenotype-of-keratitis-ichthyosis-deafness-syndrome-with-presumed-ocular-surface-squamous-neoplasia
#15
Ana Silvia Serrano-Ahumada, Vianney Cortes-González, Luz María González-Huerta, Sergio Cuevas, Luis Aguilar-Lozano, Cristina Villanueva-Mendoza
PURPOSE: The aim of this study was to describe a case of severe keratitis-ichthyosis-deafness (KID) syndrome with ocular surface squamous neoplasia. METHODS: The affected patient underwent complete ocular and systemic examinations. The molecular studies included polymerase chain reaction amplification and automated DNA sequencing of the complete gap junction beta-2 (GJB2) gene coding sequence. RESULTS: A 30-year-old man presented with generalized erythro-hyperkeratosis and deafness and complaints of decreased visual acuity, tearing, and photophobia...
October 10, 2017: Cornea
https://www.readbyqxmd.com/read/29022755/randomized-double-blind-placebo-controlled-parallel-group-multi-center-study-of-the-safety-and-efficacy-of-adam-zolmitriptan-for-the-acute-treatment-of-migraine
#16
Egilius Lh Spierings, Jan Lewis Brandes, David B Kudrow, James Weintraub, Peter C Schmidt, Donald J Kellerman, Stewart J Tepper
Objective To determine the efficacy, tolerability, and safety of ascending doses of Adhesive Dermally-Applied Microarray (ADAM) zolmitriptan versus placebo for acute migraine treatment. Background ADAM is a novel patient-administered system for intracutaneous drug administration. In a phase 1 pharmacokinetic study, zolmitriptan administered using ADAM had much faster absorption than oral administration with higher exposure in the first two hours. Methods This was a multicenter, randomized, double-blind, placebo-controlled, parallel-group Phase 2b/3 study evaluating ADAM zolmitriptan 1 mg, 1...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29020806/transcranial-static-magnetic-field-stimulation-tsms-of-the-visual-cortex-decreases-experimental-photophobia
#17
Elena Lozano-Soto, Vanesa Soto-León, Simona Sabbarese, Lara Ruiz-Alvarez, Margarita Sanchez-Del-Rio, Juan Aguilar, Bryan A Strange, Guglielmo Foffani, Antonio Oliviero
Background Transcranial static magnetic field stimulation (tSMS) reduces cortical excitability in humans. Methods The objective of this study was to determine whether tSMS over the occipital cortex is effective in reducing experimental photophobia. In a sham-controlled double-blind crossover study, tSMS (or sham) was applied for 10 minutes with a cylindrical magnet on the occiput of 20 healthy subjects. We assessed subjective discomfort induced by low-intensity and high-intensity visual stimuli presented in a dark room before, during and after tSMS (or sham)...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29020214/how-well-do-neurologic-symptoms-identify-individuals-with-neurosyphilis
#18
Arielle P Davis, Joshua Stern, Lauren Tantalo, Sharon Sahi, Sarah Holte, Shelia Dunaway, Christina M Marra
Background: Current guidelines recommend lumbar puncture (LP) in patients with syphilis who have neurologic syndromes. Methods: 81 HIV-uninfected individuals and 385 HIV-infected individuals enrolled in a study of cerebrospinal fluid (CSF) abnormalities in syphilis underwent LP and a structured symptom history, including assessment of headache; stiff neck; photophobia; ocular inflammation; vision, hearing or sensory loss; or gait incoordination. Neurosyphilis was defined as a reactive CSF-Venereal Disease Research Laboratory (VDRL) test...
September 9, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29016937/screening-for-insomnia-an-observational-study-examining-sleep-disturbances-headache-characteristics-and-psychiatric-symptoms-in-patients-visiting-a-headache-center
#19
Olivia Begasse de Dhaem, Elizabeth Seng, Mia T Minen
Objective: Effective treatments for insomnia exist, but few physicians treating headaches have routine methods for screening for insomnia. We sought to 1) describe the migraine characteristics and comorbid conditions that can affect sleep and 2) assess their relationships with positive screens on the Insomnia Severity Index (ISI). Methods: This is a retrospective cross-sectional study of the migraine and sleep characteristics of new patients in our headache center (August 15, 2015-October 28, 2015) who were suspected of having migraines based on the new patient intake questionnaire...
July 21, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28991343/endophthalmitis-following-pediatric-cataract-surgery-an-international-pediatric-ophthalmology-and-strabismus-council-global-perspective
#20
Almutez M Gharaibeh, Eedy Mezer, Luis H Ospina, Tamara Wygnanski-Jaffe
PURPOSE: To compile international data on the risk factors, diagnosis, and treatment of endophthalmitis following pediatric cataract surgery. METHODS: An e-mail containing a link to an online survey was sent to all members of the American Association for Pediatric Ophthalmology and Strabismus. The questionnaire examined the incidence, risk factors, treatment, outcomes, and prophylaxis of endophthalmitis following pediatric cataract surgery around the world. RESULTS: Two hundred thirty-seven ophthalmologists answered the questionnaire...
October 9, 2017: Journal of Pediatric Ophthalmology and Strabismus
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