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https://www.readbyqxmd.com/read/28338564/studying-the-retinal-source-of-photophobia-by-facial-electroretinography
#1
Christopher W Tyler, Lora T Likova
PURPOSE: Photophobia is a debilitating clinical condition that disrupts the ability to use vision for everyday tasks in bright lighting conditions. The goal of the study is to develop a methodology to study the neural basis of photophobia and the contribution of the melanopic pathway to its etiology with differential chromatic responses by means of standard electroencephalographic recording equipment. METHODS: We introduce and validate the approach of recording wavelength-specific electroretinographic (ERG) responses from the face electrodes of the high-density whole-head electroencephalography recording system under light-adapted conditions...
April 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28337834/retinal-dystrophy-in-two-boys-with-costello-syndrome-due-to-the-hras-p-gly13cys-mutation
#2
Mary Ella Pierpont, Mary Richards, W Keith Engel, Nancy J Mendelsohn, C Gail Summers
Features of Costello Syndrome, a systemic disorder caused by germline mutations in the proto-oncogene HRAS from the RAS/MAPK pathway, include failure-to-thrive, short stature, coarse facial features, cardiac defects including hypertrophic cardiomyopathy, intellectual disability, and predisposition to neoplasia. Two unrelated boys with Costello syndrome and an HRAS mutation (p.Gly13Cys) are presented with their ophthalmologic findings. Both had early symptoms of nystagmus, photophobia, and vision abnormalities...
March 23, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28332775/ocular-involvement-in-pemphigus-vulgaris-a-retrospective-study-of-a-large-spanish-cohort
#3
Agustin España, Pilar Iranzo, Josep Herrero-González, José M Mascaro, Ricardo Suárez
BACKGROUND AND OBJECTIVES: Ocular/periocular involvement in pemphigus vulgaris (OPV) has rarely been reported. The objective of the present study was to investigate the pattern of OPV and define the prognostic value of its manifestation. PATIENTS AND METHODS: From 1985 to 2014, a total of 167 patients with pemphigus vulgaris (PV) were treated at four tertiary Spanish hospitals. In this retrospective study, we included all patients with OPV. Clinical data and information on associated symptoms were obtained from patients' medical records...
March 23, 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28329493/ichthyosis-follicularis-with-alopecia-and-photophobia-syndrome-ifap-a-case-report
#4
Bruno Ferrari, Lucila Morita, Keith Choate, Rong-Hua Hu
IFAP syndrome is a rare autosomal recessive X-linked disease characterized by the triad of alopecia universalis, severe photophobia, and follicular ichthyosis. It is caused by loss of function of the gene MBTPS2. Its severity varies and there are only a few reports in the literature. We present a patient with characteristic clinical features and a mutation not previously reported.
February 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28295285/tolosa-hunt-syndrome-presenting-during-pregnancy-following-progesterone-administration
#5
Charles E Litwin, Annie S O Leung
Tolosa-Hunt syndrome (THS) is a rare disease with an estimated incidence of 1 case per 1 million people per year [1]. A 24 year-old woman (G2 P0 A1 ) at 37(+3) weeks of pregnancy presented at the study institution reporting a 2-week unilateral headache on the left side, worsening nausea, and 1 day of progressively worsening left eye diplopia and photophobia. No significant medical or surgical history was reported, and the index pregnancy had been uncomplicated with the exception of some first-trimester bleeding that resulted in the patient being prescribed vaginal progesterone as part of a clinical trial...
March 10, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28289999/erratum-to-psychiatric-comorbidities-and-photophobia-in-patients-with-migraine
#6
Stefan Seidel, Roland Beisteiner, Maike Manecke, Tuna Stefan Aslan, Christian Wöber
No abstract text is available yet for this article.
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28286669/long-term-complications-of-sulfur-mustard-poisoning-retinal-electrophysiological-assessment-in-40-severely-intoxicated-iranian-veterans
#7
Nasser Shoeibi, Mir Naghi Mousavi, Mahdi Balali-Mood, Mohammad Moshiri, Emadodin Darchini-Maragheh, Seyed Reza Mousavi, Mojtaba Abrishami
BACKGROUND: The eye is one of the most sensitive organs to sulfur mustard (SM) [C4H8Cl2S], and preliminary symptoms of exposure usually become evident in the eyes. In this study we aim to evaluate the possible long-term retinal electrophysiologic complications of SM poisoning in Iranian veterans during Iran-Iraq war (1980-1988). METHODS: In a cross-sectional study forty Iranian veterans who were exposed to mustard gas during the Iran-Iraq war (1980-1988) were included...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/28264130/a-new-matrix-therapy-agent-for-faster-corneal-healing-and-less-ocular-discomfort-following-epi-off-accelerated-corneal-cross-linking-in-progressive-keratoconus
#8
Koray Gumus, Marta Gomes Guerra, Sara Homem de Melo Marques, Sarper Karaküçük, Denis Barritault
PURPOSE: To investigate the hypothesis that a new matrix therapy agent (ReGeneraTing Agent, [RGTA]) would speed up the corneal reepithelialization, improve stromal healing, and reduce ocular symptoms after epi-off corneal cross-linking (CXL). METHODS: Sixty eyes of 60 patients with progressive keratoconus were enrolled in the study. Epi-off accelerated CXL was performed in all patients. Sixty eyes were randomized into two groups according to use of RGTA eye drops prior to contact lens fitting at the end...
March 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28264100/the-relation-between-light-induced-lacrimation-and-the-melanopsin-driven-postillumination-pupil-response
#9
Shaobo Lei, Herbert C Goltz, Xingqiao Chen, Marija Zivcevska, Agnes M F Wong
Purpose: To investigate the chromatic characteristics and intensity-response function of light-induced reflex lacrimation and its correlation with the melanopsin-driven postillumination pupil response (PIPR). Methods: Eleven visually normal participants completed the experiment. Lacrimation was measured in one eye by placing a calibrated filter paper strip in the conjunctival sac over a 1 minute-interval (Schirmer's test) during which participants received either no light stimulation (baseline trial) or one flash of blue or red light stimuli presented binocularly with a Ganzfeld stimulator, while the pupil response was recorded simultaneously from the fellow eye by using an eye tracker...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28262355/the-importance-of-a-neck-exam-in-sport-related-concussion-cervical-schwannoma-in-post-concussion-syndrome
#10
David M Langelier, Kathryn J Schneider, John Hurlbert, Chantel T Debert
OBJECTIVE: Few cases of cervical schwannoma have been reported following head trauma. The present case, involves a schwannoma of the C2 spinal nerve mimicking post-concussion symptoms following a sport-related concussion (SRC). DESIGN: Case study. SETTING: University of Calgary, Sport Medicine Clinic, Calgary, Alberta, Canada. RESULTS: We report a 28 year old, athlete who developed headache, dizziness, photophobia, and neck pain following a cycling accident...
January 17, 2017: Physical Therapy in Sport
https://www.readbyqxmd.com/read/28239956/spreading-of-thelazia-callipaeda-in-greece
#11
E Papadopoulos, A Komnenou, A Thomas, E Ioannidou, V Colella, D Otranto
Thelazia callipaeda (Spirurida, Thelaziidae), the so-called oriental eyeworm, has been increasingly reported as an agent of infection in animals and humans from many European countries. Clinical signs range from subclinical to moderate or severe ocular disorders (e.g., epiphora, photophobia, conjunctivitis, keratitis, ulcers). The disease has been also diagnosed in animals from countries of the Balkan area (e.g., Croatia, Bosnia and Herzegovina and Serbia), but only a single case of canine thelaziosis, presumably autochthonous, was reported in Northern Greece...
February 26, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/28217052/topical-versus-caudal-ketamine-bupivacaine-combination-for-postoperative-analgesia-in-children-undergoing-inguinal-herniotomy
#12
Hala Saad Abdel-Ghaffar, Seham Mohamed Moeen, Ahmed Mohamed Moeen
BACKGROUND: Multiple studies claim that caudal administration of ketamine causes effective postoperative analgesia. The aim of this study was to assess the clinical effectiveness of ketamine after caudal or topical administration in pediatric patients undergoing inguinal herniotomy. PATIENTS AND METHODS: This randomized, comparative, double-blind study included eighty children (aged 6 months to 6 years) received either 1 ml/kg of 0.25% bupivacaine/ketamine 0.5 mg/kg for caudal analgesia (caudal group) or 0...
January 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/28211458/molecular-genetic-and-clinical-evaluation-of-three-chinese-families-with-x-linked-ocular-albinism
#13
Xuan Zou, Hui Li, Lizhu Yang, Zixi Sun, Zhisheng Yuan, Huajin Li, Ruifang Sui
X-linked ocular albinism (OA1) is an X-linked inherited disease characterized by hypopigmentation of the fundus and nystagmus. Our study performed mutation analysis of the G protein-coupled receptor 143 gene (GPR143) and assessed the clinical characteristics of OA1 in three Chinese families. Three novel mutations, c.333_360+14del42insCTT, c.276G>A (p.W92X), and c.793C>T (p.R265X), were identified in GPR143 by PCR followed by Sanger sequencing in these families. All affected individuals presented with nystagmus, photophobia, poor visual acuity, foveal hypoplasia and varying degrees of hypopigmentation of the fundus...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28209324/japanese-guidelines-for-allergic-conjunctival-diseases-2017
#14
REVIEW
Etsuko Takamura, Eiichi Uchio, Nobuyuki Ebihara, Shigeaki Ohno, Yuichi Ohashi, Shigeki Okamoto, Naoki Kumagai, Yoshiyuki Satake, Jun Shoji, Yayoi Nakagawa, Kenichi Namba, Kazumi Fukagawa, Atsuki Fukushima, Hiroshi Fujishima
The definition, classification, pathogenesis, test methods, clinical findings, criteria for diagnosis, and therapies of allergic conjunctival disease are summarized based on the Guidelines for Clinical Management of Allergic Conjunctival Disease (Second Edition) revised in 2010. Allergic conjunctival disease is defined as "a conjunctival inflammatory disease associated with a Type I allergy accompanied by some subjective or objective symptoms." Allergic conjunctival disease is classified into allergic conjunctivitis, atopic keratoconjunctivitis, vernal keratoconjunctivitis, and giant papillary conjunctivitis...
February 10, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28185159/psychiatric-comorbidities-and-photophobia-in-patients-with-migraine
#15
Stefan Seidel, Roland Beisteiner, Maike Manecke, Tuna Stefan Aslan, Christian Wöber
BACKGROUND: Based on recent findings and our own impressions we took a closer look at the relationship between (inter)ictal photophobia and psychometric variables in migraine patients with photophobia. FINDINGS: For this study we included 29 (27 female) migraine patients and 31 (18 female) controls with a mean age of 31.6 ± 12.5 years and 24.0 ± 4.1 years, respectively. All participants filled out the Depression Anxiety Stress Scale (DASS). Interictal photophobia in patients was significantly higher than photophobia in controls (p = ...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28179394/pathophysiology-of-migraine-a-disorder-of-sensory-processing
#16
REVIEW
Peter J Goadsby, Philip R Holland, Margarida Martins-Oliveira, Jan Hoffmann, Christoph Schankin, Simon Akerman
Plaguing humans for more than two millennia, manifest on every continent studied, and with more than one billion patients having an attack in any year, migraine stands as the sixth most common cause of disability on the planet. The pathophysiology of migraine has emerged from a historical consideration of the "humors" through mid-20th century distraction of the now defunct Vascular Theory to a clear place as a neurological disorder. It could be said there are three questions: why, how, and when? Why: migraine is largely accepted to be an inherited tendency for the brain to lose control of its inputs...
April 2017: Physiological Reviews
https://www.readbyqxmd.com/read/28176235/randomized-double-blind-crossover-study-comparing-dfn-11-injection-3%C3%A2-mg-subcutaneous-sumatriptan-with-6%C3%A2-mg-subcutaneous-sumatriptan-for-the-treatment-of-rapidly-escalating-attacks-of-episodic-migraine
#17
RANDOMIZED CONTROLLED TRIAL
Roger K Cady, Sagar Munjal, Ryan J Cady, Heather R Manley, Elimor Brand-Schieber
BACKGROUND: A 6-mg dose of SC sumatriptan is the most efficacious and fast-acting acute treatment for migraine, but a 3-mg dose of SC sumatriptan may improve tolerability while maintaining efficacy. METHODS: This randomized, double-blind, crossover study compared the efficacy and tolerability of 3 mg subcutaneous (SC) sumatriptan (DFN-11) with 6 mg SC sumatriptan in 20 adults with rapidly-escalating migraine attacks. Eligible subjects were randomized (1:1) to treat 1 attack with DFN-11 and matching placebo autoinjector consecutively or 2 DFN-11 autoinjectors consecutively and a second attack similarly but with the alternative dose (3 mg or 6 mg)...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28170093/topical-treatments-for-blepharokeratoconjunctivitis-in-children
#18
REVIEW
Michael O'Gallagher, Catey Bunce, Melanie Hingorani, Frank Larkin, Stephen Tuft, Annegret Dahlmann-Noor
BACKGROUND: Blepharokeratoconjunctivitis (BKC) is a type of inflammation of the surface of the eye and eyelids that involves changes of the eyelids, dysfunction of the meibomian glands, and inflammation of the conjunctiva and cornea. Chronic inflammation of the cornea can lead to scarring, vascularisation and opacity. BKC in children can cause significant symptoms including irritation, watering, photophobia and loss of vision from corneal opacity, refractive error or amblyopia.Treatment of BKC is directed towards modification of meibomian gland disease and the bacterial flora of lid margin and conjunctiva, and control of ocular surface inflammation...
February 7, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28137823/topical-tacrolimus-solution-in-autoimmune-polyglandular-syndrome-1-associated-keratitis
#19
Samir S Shoughy, Khalid F Tabbara
PURPOSE: To evaluate the efficacy of topical tacrloimus eye drops in the treatment of keratitis associated with autoimmune polyglandular syndrome (APS)-1. METHODS: This is a retrospective review of 10 patients with APS-1. The patients were treated with topical tacrolimus 0.01% solution at The Eye Center, between 1 March 2012 and 30 April 2016. The outcome measures included improvement in visual acuity, photophobia and keratitis following treatment. Clinical assessment was carried out before, during and on the last visit following initiation of therapy...
January 30, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28124109/decompression-endoscopic-surgery-for-frontal-secondary-headache-attributed-to-supraorbital-and-supratrochlear-nerve-entrapment-a-comprehensive-review
#20
REVIEW
Boris Filipović, J Alexander de Ru, Rick van de Langenberg, Pepijn A Borggreven, Zdravko Lacković, Peter J F M Lohuis
In the last decade, a new surgical treatment modality was developed for frontal secondary headache, based on the assumption that the trigger of this pain entity is the entrapment of peripheral sensory nerves. The surgery entails a procedure, where an endoscopic approach is used to decompress the supraorbital and supratrochlear nerve branches, which are entrapped by the periosteum in the region of the corrugator supercilii muscle. Candidates for the surgery define their headache as moderate to severe persistent daily pressure or tension, localized in the frontal area, sometimes accompanied by symptoms of nausea and photophobia mimicking a primary headache-migraine...
January 25, 2017: European Archives of Oto-rhino-laryngology
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