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https://www.readbyqxmd.com/read/28101292/is-allergic-sensitization-relevant-in-severe-asthma-which-allergens-may-be-culprit
#1
REVIEW
Carlo Lombardi, Eleonora Savi, Erminia Ridolo, Giovanni Passalacqua, Giorgio Walter Canonica
Severe asthma is a major health concern. The allergic (IgE-mediated) form of asthma is well known from a pathogenic viewpoint. We searched the available literature to identify which allergens are most frequently associated with severe, refractory or life threatening asthma. According to the results, molds, pet dander, cockroach and ragweed were more frequently responsible for severe asthma. Thunderstorm asthma, in addition, represents a special association between allergic sensitization and an external climatic factor...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28100601/the-use-of-selective-fungal-culture-media-increases-detection-rates-of-fungi-in-the-cystic-fibrosis-respiratory-tract
#2
Gina Hong, Heather B Miller, Sarah Allgood, Richard Lee, Noah Lechtzin, Sean X Zhang
The prevalence of fungi in the respiratory tract of cystic fibrosis (CF) patients has risen. However, fungal surveillance is not routinely performed in most clinical centers in the United States, which may lead to an underestimation of the true prevalence of the problem. We conducted a prospective study comparing fungal detection rates for clinically important fungi (CIF) defined as Aspergillus species, Scedosporium species, Trichosporon species, and Exophiala dermatitidis in CF sputum using standard bacterial culture media and selective-fungal culture media, including Sabouraud dextrose agar with gentamicin (SDA), inhibitory mold agar (IMA), and brain-heart infusion agar (BHI) with chloramphenicol and gentamicin...
January 18, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28098752/microbiological-load-of-edible-insects-found-in-belgium
#3
Rudy Caparros Megido, Sandrine Desmedt, Christophe Blecker, François Béra, Éric Haubruge, Taofic Alabi, Frédéric Francis
Edible insects are gaining more and more attention as a sustainable source of animal protein for food and feed in the future. In Belgium, some insect products can be found on the market, and consumers are sourcing fresh insects from fishing stores or towards traditional markets to find exotic insects that are illegal and not sanitarily controlled. From this perspective, this study aims to characterize the microbial load of edible insects found in Belgium (i.e., fresh mealworms and house crickets from European farms and smoked termites and caterpillars from a traditional Congolese market) and to evaluate the efficiency of different processing methods (blanching for all species and freeze-drying and sterilization for European species) in reducing microorganism counts...
January 13, 2017: Insects
https://www.readbyqxmd.com/read/28096447/pbp1b-glycosyltransferase-and-transpeptidase-activities-play-different-essential-roles-during-the-de-novo-regeneration-of-rod-shaped-morphology-in-escherichia-coli
#4
Dev K Ranjit, Matthew A Jorgenson, Kevin D Young
: Peptidoglycan is a vital component of nearly all cell wall-bearing bacteria and is a valuable target for antibacterial therapy. However, despite decades of work, there remain important gaps in understanding how this macromolecule is synthesized and molded into a three-dimensional structure that imparts specific morphologies to individual cells. Here, we investigate the particularly enigmatic area of how peptidoglycan is synthesized and shaped during the first stages of creating cell shape de novo, that is, in the absence of a pre-existing template...
January 17, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28094976/breath-figure-micromolding-approach-for-regulating-the-microstructures-of-polymeric-films-for-triboelectric-nanogenerators
#5
Jianliang Gong, Bingang Xu, Xiaoming Tao
Triboelectric nanogenerator (TENG) is an innovative kind of energy harvester recently developed based on organic materials for converting mechanical energy into electricity through the conjunction use of triboelectric effect and electrostatic induction. Polymeric materials and their microstructures play key roles in the generation, accumulation, and retainment of triboelectric charges, which decisively determines the final electric performance of TENGs. Herein we report a simple and efficient breath figure micromolding approach to rapidly regulate the surface microstructures of polymeric films for the assembly of TENGs...
January 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28094689/quantification-of-rectifications-for-the-northwestern-university-flexible-sub-ischial-vacuum-socket
#6
Stefania Fatone, William Brett Johnson, Lilly Tran, Kerice Tucker, Christofer Mowrer, Ryan Caldwell
BACKGROUND: The fit and function of a prosthetic socket depend on the prosthetist's ability to design the socket's shape to distribute load comfortably over the residual limb. We recently developed a sub-ischial socket for persons with transfemoral amputation: the Northwestern University Flexible Sub-Ischial Vacuum Socket. OBJECTIVE: This study aimed to quantify the rectifications required to fit the Northwestern University Flexible Sub-Ischial Vacuum Socket to teach the technique to prosthetists as well as provide a computer-aided design-computer-aided manufacturing option...
January 1, 2017: Prosthetics and Orthotics International
https://www.readbyqxmd.com/read/28094686/northwestern-university-flexible-subischial-vacuum-socket-for-persons-with-transfemoral-amputation-part-1-description-of-technique
#7
Stefania Fatone, Ryan Caldwell
BACKGROUND: Current transfemoral prosthetic sockets restrict function, lack comfort, and cause residual limb problems. Lower proximal trim lines are an appealing way to address this problem. Development of a more comfortable and possibly functional subischial socket may contribute to improving quality of life of persons with transfemoral amputation. OBJECTIVES: The purpose of this study was to (1) describe the design and fabrication of a new subischial socket and (2) describe efforts to teach this technique...
January 1, 2017: Prosthetics and Orthotics International
https://www.readbyqxmd.com/read/28092188/a-longitudinal-study-of-factors-explaining-attitude-change-towards-gambling-among-adolescents
#8
Ståle Pallesen, Daniel Hanss, Helge Molde, Mark D Griffiths, Rune Aune Mentzoni
Background and aims No previous study has investigated changes in attitudes toward gambling from under legal gambling age to legal gambling age. The aim of the present study was therefore to investigate attitudinal changes during this transition and to identify predictors of corresponding attitude change. Methods In all 1239 adolescents from a national representative sample participated in two survey waves (Wave 1; 17.5 years; Wave 2; 18.5 years). Results From Wave 1 to Wave 2 the sample became more acceptant toward gambling...
March 2016: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/28089333/fit-of-interim-crowns-fabricated-using-photopolymer-jetting-3d%C3%A2-printing
#9
Hang-Nga Mai, Kyu-Bok Lee, Du-Hyeong Lee
STATEMENT OF PROBLEM: The fit of interim crowns fabricated using 3-dimensional (3D) printing is unknown. PURPOSE: The purpose of this in vitro study was to evaluate the fit of interim crowns fabricated using photopolymer-jetting 3D printing and to compare it with that of milling and compression molding methods. MATERIAL AND METHODS: Twelve study models were fabricated by making an impression of a metal master model of the mandibular first molar...
January 12, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28088667/cell-laden-hydrogels-for-osteochondral-and-cartilage-tissue-engineering
#10
REVIEW
Jingzhou Yang, Yu Shrike Zhang, Kan Yue, Ali Khademhosseini
: Despite tremendous advances in the field of regenerative medicine, it still remains challenging to repair the osteochondral interface and full-thickness articular cartilage defects. This inefficiency largely originates from the lack of appropriate tissue engineered artificial matrices that can replace the damaged regions and promote tissue regeneration. Hydrogels are emerging as a promising class of biomaterials for both soft and hard tissue regeneration. Many critical properties of hydrogels, such as mechanical stiffness, elasticity, water content, bioactivity, and degradation, can be rationally designed and conveniently tuned by proper selection of the material and chemistry...
January 11, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28088418/laboratory-silo-type-and-inoculation-effects-on-nutritional-composition-fermentation-and-bacterial-and-fungal-communities-of-oat-silage
#11
J J Romero, Y Zhao, M A Balseca-Paredes, F Tiezzi, E Gutierrez-Rodriguez, M S Castillo
The objectives were to evaluate (1) the use of 2 types of experimental silos (S) to characterize whole-crop oat (Avena sativa L.) silage with or without addition of an inoculant (I), and (2) the effect of inoculation on the microbial community structure of oats ensiled using only plastic bucket silos (BKT). From each of 6 sections in a field, oats were harvested, treated (INO) or not (CON) with inoculant, packed into 19-L BKT or vacuum bags (BG), and ensiled for 217 d. The inoculant added contained Lactobacillus buchneri and Pediococcus pentosaceus (4 × 10(5) and 1 × 10(5) cfu/g of fresh oats, respectively)...
January 11, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28087871/poison-ivy-how-effective-are-available-treatments
#12
Cara K Vaught, James W Mold
In this study, only one treatment approach significantly reduced pruritus. Three approaches were often associated with recurrences of rash or symptoms.
November 2016: Journal of Family Practice
https://www.readbyqxmd.com/read/28081106/broad-bandwidth-reversible-and-high-contrast-ratio-optical-diode
#13
Chao Li, Min Wang, Jun-Fang Wu
Fano resonance is widely used to realize high-contrast nonreciprocal transmission. However, resonance-enhanced all-optical diodes (AOD) are bandwidth-limited, and their transmission rates are normally low, which restricts realistic application. In this Letter, we analytically and numerically demonstrate that this limitation can be overcome once multistability of cascaded nonlinear cavities is appropriately excited. By precisely molding the transiting of the signal light between multistable states, a high-contrast-ratio, high-unidirectional-transmission-rate, and reversal-controllable AOD is achieved with a bandwidth over 2...
January 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28080024/direct-fabrication-of-micro-nano-patterned-surfaces-by-vertical-directional-photofluidization-of-azobenzene-materials
#14
Jaeho Choi, Wonhee Cho, Yeon Sik Jung, Hong Suk Kang, Hee-Tak Kim
Anisotropic movement of azobenzene materials (i.e., azobenzene molecules incorporated in polymer, glass, or supramolecules) has provided significant opportunities for the fabrication of micro/nanoarchitectures. The examples include circular holes, line gaps, ellipsoidal holes, and nanofunnels. However, all of the previous studies have only focused on the lateral directional movement for the structural shaping of azobenzene materials. Herein, we propose structural shaping based on a vertical directional movement of azobenzene materials...
January 12, 2017: ACS Nano
https://www.readbyqxmd.com/read/28078073/soft-encapsulation-of-flexible-electrical-stimulation-implant-challenges-and-innovations
#15
Adrien Debelle, Laura Hermans, Maxime Bosquet, Sam Dehaeck, Laurent Lonys, Benoit Scheid, Antoine Nonclercq, Anne Vanhoestenberghe
In this document we discuss the main challenges encountered when producing flexible electrical stimulation implants, and present our approach to solving them for prototype production. We include a study of the optimization of the flexible PCB design, the selection of additive manufacturing materials for the mold, and the chemical compatibility of the different materials. Our approach was tested on a flexible gastro-stimulator as part of the ENDOGES research program.
September 15, 2016: European Journal of Translational Myology
https://www.readbyqxmd.com/read/28076995/biosurfactants-in-cosmetic-formulations-trends-and-challenges
#16
X Vecino, J M Cruz, A B Moldes, L R Rodrigues
Cosmetic products play an essential role in everyone's life. People everyday use a large variety of cosmetic products such as soap, shampoo, toothpaste, deodorant, skin care, perfume, make-up, among others. The cosmetic industry encompasses several environmental, social and economic impacts that are being addressed through the search for more efficient manufacturing techniques, the reduction of waste and emissions and the promotion of personal hygiene, contributing to an improvement of public health and at the same time providing employment opportunities...
January 12, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28070698/drug-coated-microneedles-for-rapid-and-painless-local-anesthesia
#17
Sung-Hyun Baek, Ju-Hyung Shin, Yeu-Chun Kim
This study showed that drug-coated PLLA (Poly (L-lactide)) microneedle arrays can induce rapid and painless local anesthesia. Microneedle arrays were fabricated using a micro-molding technique, and the needle tips were coated with 290.6 ± 45.9 μg of lidocaine, the most widely used local anesthetic worldwide. A dip-coating device was newly designed for the coating step using an optimized coating formulation. Lidocaine coated on the arrays was released rapidly into PBS within 2 min, and its stability in storage lasted 3 weeks at 4, 25, and 37°C...
March 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28069561/cancer-survivors-experience-with-telehealth-a-systematic-review-and-thematic-synthesis
#18
REVIEW
Anna Cox, Grace Lucas, Afrodita Marcu, Marianne Piano, Wendy Grosvenor, Freda Mold, Roma Maguire, Emma Ream
BACKGROUND: Net survival rates of cancer are increasing worldwide, placing a strain on health service provision. There is a drive to transfer the care of cancer survivors-individuals living with and beyond cancer-to the community and encourage them to play an active role in their own care. Telehealth, the use of technology in remote exchange of data and communication between patients and health care professionals (HCPs), is an important contributor to this evolving model of care. Telehealth interventions are "complex," and understanding patient experiences of them is important in evaluating their impact...
January 9, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28068484/informatics-and-data-analytics-to-support-exposome-based-discovery-for-public-health
#19
Arjun K Manrai, Yuxia Cui, Pierre R Bushel, Molly Hall, Spyros Karakitsios, Carolyn J Mattingly, Marylyn Ritchie, Charles Schmitt, Denis A Sarigiannis, Duncan C Thomas, David Wishart, David M Balshaw, Chirag J Patel
The complexity of the human exposome-the totality of environmental exposures encountered from birth to death-motivates systematic, high-throughput approaches to discover the environmental determinants of disease. In this review, we describe the state of science in analyzing the human exposome and provide recommendations for the public health community to consider in dealing with analytic challenges of exposome-based biomedical research. We describe extant and novel analytic methods needed to associate the exposome with critical health outcomes and contextualize the data-centered challenges by drawing parallels to other research endeavors such as human genomics research...
December 23, 2016: Annual Review of Public Health
https://www.readbyqxmd.com/read/28067917/structural-insights-into-a-unique-hsp70-hsp40-interaction-in-the-eukaryotic-ribosome-associated-complex
#20
Felix Alexander Weyer, Andrea Gumiero, Genís Valentín Gesé, Karine Lapouge, Irmgard Sinning
Cotranslational chaperones assist de novo folding of nascent polypeptides, prevent them from aggregating and modulate translation. The ribosome-associated complex (RAC) is unique in that the Hsp40 protein Zuo1 and the atypical Hsp70 chaperone Ssz1 form a stable heterodimer, which acts as a cochaperone for the Hsp70 chaperone Ssb. Here we present the structure of the Chaetomium thermophilum RAC core comprising Ssz1 and the Zuo1 N terminus. We show how the conserved allostery of Hsp70 proteins is abolished and this Hsp70-Hsp40 pair is molded into a functional unit...
January 9, 2017: Nature Structural & Molecular Biology
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