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https://www.readbyqxmd.com/read/28453437/umbilical-cord-as-human-cell-source-for-mitral-valve-tissue-engineering-venous-vs-arterial-cells
#1
Axel Malischewski, Ricardo Moreira, Luis Hurtado, Valentine Gesché, Thomas Schmitz-Rode, Stefan Jockenhoevel, Petra Mela
Around 2% of the population in developed nations are affected by mitral valve disease and available valvular replacements are not designed for the atrioventricular position. Recently our group developed the first tissue-engineered heart valve (TEHV) specifically designed for the mitral position - the TexMi valve. The valve recapitulates the main components of the native valve, i.e. annulus, asymmetric leaflets and the crucial chordae tendineae. In the present study, we evaluated the human umbilical cord as a clinically applicable cell source for the TexMi valve...
April 28, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28453304/mold-allergy-is-it-real-and-what-do-we-do-about-it
#2
Amanda Rudert, Jay Portnoy
Fungi produce substances that contain pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) which bind to pattern recognition receptors, stimulating innate immune responses in humans. They also produce allergens that induce production of specific IgE. Areas Covered: In this review we cover both innate and adaptive immune responses to fungi. Some fungal products can activate both innate and adaptive responses and in doing so, cause an intense and complex health effects...
April 28, 2017: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/28453293/predicting-a-drug-s-membrane-permeability-a-computational-model-validated-with-in-vitro-permeability-assay-data
#3
Brian J Bennion, Nicholas A Be, Margaret Windy McNerney, Victoria Lao, Emma M Carlson, Carlos A Valdez, Michael A Malfatti, Heather A Enright, Tuan H Nguyen, Felice C Lightstone, Timothy S Carpenter
Membrane permeability is a key property to consider during the drug design process, and particularly vital when dealing with small molecules that have intracellular targets as their efficacy highly depends on their ability to cross the membrane. In this work, we describe the use of umbrella sampling Molecular Dynamics (MD) computational modeling to comprehensively assess the passive permeability profile of a range of compounds through a lipid bilayer. The model was initially calibrated through in vitro validation studies employing a Parallel Artificial Membrane Permeability Assay (PAMPA)...
April 28, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28448223/the-alerrt-%C3%A2-instrument-a-quantitative-measure-of-the-effort-required-to-compromise-prescription-opioid-abuse-deterrent-tablets
#4
Edward J Cone, August R Buchhalter, Karsten Lindhardt, Torben Elhauge, Jeffrey M Dayno
BACKGROUND: US FDA guidance recommends measuring the degree of effort needed to manipulate abuse-deterrent (AD) opioids. The ALERRT(®) instrument (PinneyAssociates; Bethesda, MD) uses visual analog scales to assess the labor, effort, and resources necessary to physically compromise AD product candidates in standardized settings. OBJECTIVE: Use the ALERRT(®) instrument for testing morphine abuse-deterrent, extended-release, injection-molded tablets (ADER-IMT) 60 and 100 mg and the comparators immediate-release (IR) morphine sulfate 30 mg and extended-release (ER) morphine sulfate 60 mg...
May 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/28447994/scaling-of-engineered-vascular-grafts-using-3d-printed-guides-and-the-ring-stacking-method
#5
Cameron B Pinnock, Zhengfan Xu, Mai T Lam
Coronary artery disease remains a leading cause of death, affecting millions of Americans. With the lack of autologous vascular grafts available, engineered grafts offer great potential for patient treatment. However, engineered vascular grafts are generally not easily scalable, requiring manufacture of custom molds or polymer tubes in order to customize to different sizes, constituting a time-consuming and costly practice. Human arteries range in lumen diameter from about 2.0-38 mm and in wall thickness from about 0...
March 27, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28447136/-environmental-health-relevance-of-airborne-microorganisms-in-ambient-and-indoor-air
#6
REVIEW
Sandra M Walser, Bernhard Brenner, Stefanie Heinze, Regine Szewzyk, Eike Wolter, Caroline E W Herr
Airborne microorganisms occur ubiquitously in the ambient air. Besides allergic and irritative-toxic effects, they can cause infections after inhalation. Occupational studies have shown that an increased incidence of respiratory diseases is found in adequately exposed workers. In addition to respiratory diseases, severe systemic infections can also occur in particular cases, such as in the case of a hantavirus infection that is recognized as an occupational disease. In studies from environmental medicine, respiratory diseases have also been observed in residents living in the vicinity of livestock facilities and evaporative cooling towers...
April 26, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28445166/repurposing-compact-discs-as-master-molds-to-fabricate-high-performance-organic-nanowire-field-effect-transistors
#7
Kyunghun Kim, Jinhwi Cho, Heesauk Jhon, Jongwook Jeon, Myounggon Kang, Chan Eon Park, Jihoon Lee, Tae Kyu An
Organic field-effect transistors (OFETs) have been developed over the past few decades due to their potential applications in future electronics such as wearable and foldable electronics. As the electrical performance of OFETs has improved, patterning organic semiconducting crystals has become a key issue for their commercialization. However, conventional soft lithographic techniques have required the use of expensive processes to fabricate high-resolution master molds. In this study, we demonstrated a cost-effective method to prepare nanopatterned master molds for the fabrication of high-performance nanowire OFETs...
May 19, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28445164/simple-and-scalable-preparation-of-master-mold-for-nanoimprint-lithography
#8
Yuri Yamada, Kota Ito, Atsushi Miura, Hideo Iizuka, Hiroaki Wakayama
Nanoimprint lithography (NIL) is one of the most prominent bottom-up techniques for duplicating nanostructures with a high throughput. However, fabrication of starting master mold commonly requires expensive equipment of top-down techniques, or additional steps to transfer the fabricated patterns from bottom-up methods. Here we demonstrate that a SiO2 nanostructure manufactured from a self-assembled block copolymer, polystyrene-b-polydimethylsiloxane (PS-b-PDMS), directly serves as a master mold for NIL without further modification...
May 19, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28444619/the-reference-cube-a-new-ballistic-model-to-generate-staining-in-firearm-barrels
#9
Christian Schyma, Kristina Bauer, Julia Brünig
After contact shots to the head biological traces can be found inside firearm barrels. So far silicone coated, gelatin filled box models were used to generate such staining according to the triple contrast method (mixture of acrylic paint, barium sulfate and blood sealed in a thin foil bag). This study was conducted to develop a transparent ballistic model allowing contact shots. Gelatin filled polyethylene bottles with and without a silicone coat were tested in comparison to non-covered gelatin blocks. Finally, thin foil bags of 5 cm × 5 cm dimension were glued on a synthetic absorbent kitchen wipe on top of which 1 L 10% gelatin solution was molded to create blocks of 8...
April 25, 2017: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/28443860/fabrication-of-large-area-polymer-microfilter-membranes-and-their-application-for-particle-and-cell-enrichment
#10
Javier Alejandro Hernández-Castro, Kebin Li, Anne Meunier, David Juncker, Teodor Veres
A vacuum assisted UV micro-molding (VAUM) process is proposed for the fabrication of freestanding and defect-free polymer membranes based on a UV-curable methacrylate polymer (MD 700). VAUM is a highly flexible and powerful method for fabricating low cost, robust, large-area membranes over 9 × 9 cm(2) with pore sizes from 8 to 20 μm in diameter, 20 to 100 μm in thickness, high aspect ratio (the thickness of the polymer over the diameter of the hole is up to 15 : 1), high porosity, and a wide variety of geometrical characteristics...
April 26, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28440038/induced-chemical-defense-of-a-mushroom-by-a-double-bond-shifting-polyene-synthase
#11
Philip Brandt, María García-Altares, Markus Nett, Christian Hertweck, Dirk Hoffmeister
The antilarval mushroom polyenes 18-methyl-19-oxoicosaoctaenoic acid and 20-methyl-21-oxodocosanonaenoic acid appear in response to injury of the mycelium of the stereaceous mushroom BY1. We identified a polyketide synthase (PPS1) which belongs to a hitherto completely uncharacterized clade of polyketide synthases. Expression of the PPS1 gene is massively upregulated following mycelial damage. The synthesis of the above polyenes was reconstituted in the mold Aspergillus niger as a heterologous host. This demonstrates that PPS1 1) synchronously produces branched-chain polyketides of varied lengths, and 2) catalyzes the unprecedented shift of eight or nine double bonds...
April 25, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28439577/shear-bond-strength-of-lining-materials-to-calciumsilicate-cements-at-different-time-intervals
#12
Alena Schmidt, Edgar Schäfer, Till Dammaschke
PURPOSE: To compare the shear bond strength of three different light-curing, flowable composites (Ionoseal [IS], Vertise flow [VF], and Futurabond NR + Grandio Flow [GF]) on MTA-Angelus [MTA] or Biodentine [BD] at three different time intervals. MATERIALS AND METHODS: Freshly mixed MTA or BD was applied into 180 identical plaster molds. Three minutes, 15 min, and 2 days after mixing, specimens of IS, VF, and GF with standardized size and diameter were applied on MTA and BD specimens (n = 10 per material and time interval)...
April 21, 2017: Journal of Adhesive Dentistry
https://www.readbyqxmd.com/read/28438703/multilayered-membranes-with-tuned-well-arrays-to-be-used-as-regenerative-patches
#13
Nádia I Martins, Maria P Sousa, Catarina A Custódio, Vânia C Pinto, Paulo J Sousa, Graça Minas, Franck Cleymand, João F Mano
Membranes have been explored as patches in tissue repair and regeneration, most of them presenting a flat geometry or a patterned texture at the nano/micrometer scale. Herein, a new concept of a flexible membrane featuring well arrays forming pore-like environments to accommodate cell culture is proposed. The processing of such membranes using polysaccharides is based on the production of multilayers using the layer-by-layer methodology over a patterned PDMS substrate. The detached multilayered membrane exhibits a layer of open pores at one side and a total thickness of 38 ± 2...
April 21, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28434826/the-accuracy-of-patient-specific-implant-prebented-with-3d-printed-rapid-prototype-model-for-orbital-wall-reconstruction
#14
Young Chul Kim, Woo Shik Jeong, Tae-Kyung Park, Jong Woo Choi, Kyung S Koh, Tae Suk Oh
BACKGROUND: This study evaluated the accuracy of blow out fracture reduction using 3D-printed rapid prototyping (RP) skull modeling. PATIENTS AND METHODS: Retrospective review was performed for 82 patients who underwent post-traumatic orbital wall fracture reduction between 2012 and 2014. Patients were divided into two groups according to the use of 3D-printed RP skull model reproduced by mirroring technique, onto which a titanium mesh was anatomically molded. Using computed tomographic scans, the areas of pre- and post-operative orbital wall defect, the layout angles of the titanium mesh, and the gap lengths between the implant and fracture margin were compared between the two groups...
March 27, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28432177/a-peptide-adhesive-molded-by-magnesium-glues-rubisco-s-subunits-together
#15
Rebekka M Wachter
Rubisco enzymes play central roles in carbon fixation, with potential importance in biotechnology, but have eluded a full description of their multistep assembly and function. A new article describes the fascinating discovery that some archaeal Rubiscos contain a built-in assembly domain inserted into an otherwise canonical Rubisco fold, providing a tremendous expansion of our understanding of the diversity of naturally occurring Rubiscos.
April 21, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28430244/numerical-optimization-platform-for-precision-glass-molding-by-the-simplex-algorithm
#16
Weidong Liu, Liangchi Zhang
Precision glass molding (PGM) can fabricate aspherical lens and irregular optical products in a single step, but its applicability is currently limited by the thermally induced residual stresses and lens shape derivation after molding. To remove this barrier, this paper develops a numerical optimization platform for PGM based on a simplex algorithm and finite element simulation. It was found that the platform can effectively reduce the residual stress in a molded lens through cooling process optimization and minimize the lens shape derivation by die shape compensation...
April 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/28427629/development-of-a-novel-folate-modified-nanobubbles-with-improved-targeting-ability-to-tumor-cells
#17
Sujuan Duan, Lu Guo, Dandan Shi, Mengmeng Shang, Dong Meng, Jie Li
Conjugation of folate (FOL) to nanobubbles could enhance the selective targeting to tumors expressing high levels of folate receptor (FR). To further improve the selective targeting ability of FOL-modified nanobubbles, a novel FOL-targeted nanobubble ((FOL)2-NB) with increasing FOL content (accomplished by linking two FOL molecules per DSPE-PEG2000 chain) was synthesized, through the methods of mechanical shaking and low-speed centrifugation based on lipid-stabilized perfluoropropane. The bubble size and distribution range were measured by dynamic light scattering (DLS)...
July 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28424858/electrochemical-simulation-of-biotransformation-reactions-of-citrinin-and-dihydroergocristine-compared-to-uv-irradiation-and-fenton-like-reaction
#18
Julia Keller, Hajo Haase, Matthias Koch
Mycotoxins occur widely in foodstuffs and cause a variety of mold-related health risks to humans and animals. Elucidation of the metabolic fate of mycotoxins and the growing number of newly discovered mycotoxins have enhanced the demand for fast and reliable simulation methods. The viability of electrochemistry coupled with mass spectrometry (EC/ESI-MS), Fenton-like oxidation, and UV irradiation for the simulation of oxidative phase I metabolism of the mycotoxins citrinin (CIT) and dihydroergocristine (DHEC) was investigated...
April 19, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28423881/effects-of-calcium-propionate-on-the-fermentation-quality-and-aerobic-stability-of-alfalfa-silage
#19
Zhi Hao Dong, Xian Jun Yuan, Ai You Wen, Seare T Desta, Tao Shao
Objective: To assess the potency of calcium propionate used as silage additive, an experiment was carried out to evaluate the effect of calcium propionate on the nitrogen transformation, fermentation quality and aerobic stability of alfalfa silages. Methods: Alfalfa was ensiled with four levels of calcium propionate (CAP; 5, 10, 15 and 20 g kg-1 of fresh weigh) in laboratory silos for 30 days. After opening, the silages were analyzed for the chemical and microbiological characteristics, and subjected to an aerobic stability test...
March 25, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28422679/a-bio-inspired-approach-to-traffic-network-equilibrium-assignment-problem
#20
Xiaoge Zhang, Sankaran Mahadevan
Finding an equilibrium state of the traffic assignment plays a significant role in the design of transportation networks. We adapt the path finding mathematical model of slime mold Physarum polycephalum to solve the traffic equilibrium assignment problem. We make three contributions in this paper. First, we propose a generalized Physarum model to solve the shortest path problem in directed and asymmetric graphs. Second, we extend it further to resolve the network design problem with multiple source nodes and sink nodes...
April 14, 2017: IEEE Transactions on Cybernetics
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