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https://www.readbyqxmd.com/read/28729164/antenatal-antipsychotic-exposure-induces-multigenerational-and-gender-specific-programming-of-adiposity-and-glucose-tolerance-in-adult-mouse-offspring
#1
E Courty, P Gobalakichenane, M Garcia, A Muscat, C Kazakian, T Ledent, M Moldes, B Blondeau, D Mitanchez, M Buyse, B Fève
Second-generation antipsychotics (SGAs) are well known for their metabolic side effects in humans, including obesity and diabetes. These compounds are maintained during pregnancy to prevent the relapse of psychoses, but they readily diffuse across the placenta to the fetus, as documented with the widely-prescribed drug olanzapine (OLZ). However, observational studies have provided conflicting results on the potential impact of SGAs on fetal growth and body weight, and their effects on metabolic regulation in the offspring...
July 17, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28728980/the-role-of-hexon-protein-as-a-molecular-mold-in-patterning-the-protein-ix-organization-in-human-adenoviruses
#2
Vijay S Reddy
Adenoviruses are respiratory, ocular and enteric pathogens that form complex capsids, which are assembled from seven different structural proteins and composed of several core proteins that closely interact with the packaged dsDNA genome. The recent near-atomic resolution structures revealed that the interlacing continuous hexagonal network formed by the protein IX (IX) molecules is conserved among different human adenoviruses (HAdVs), but not in non-human adenoviruses (non-HAdVs). In this report we propose a distinct role for the hexon protein as a "molecular mold" in enabling the formation of such hexagonal IX-network that has been shown to preserve the stability, infectivity of HAdVs...
July 17, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/28728969/a-nanoporous-titanium-surface-promotes-the-maturation-of-focal-adhesions-and-the-formation-of-filopodia-with-distinctive-nanoscale-protrusions-by-osteogenic-cells
#3
Dainelys Guadarrama Bello, Aurélien Fouillen, Antonella Badia, Antonio Nanci
While topography is a key determinant of the cellular response to biomaterials the mechanisms implicated in the cell-surface interactions are complex and still not fully elucidated. In this context, we have examined the effect of nanoscale topography on the formation of filopodia, focal adhesions, and on gene expression of proteins associated with cell adhesion and sensing. Commercially pure titanium discs were treated for oxidative nanopatterning with a solution of H2SO4/H2O2 50:50 (v/v). Scanning electron microscopy and atomic force microscopy characterizations showed that this facile chemical treatment efficiently creates a unique nanoporous surface with a root-mean-square roughness of 11...
July 17, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28728399/fermentation-quality-and-in-vitro-methane-production-of-sorghum-silage-prepared-with-cellulase-and-lactic-acid-bacteria
#4
Waroon Khota, Suradej Pholsen, David Higgs, Cai Yimin
Objective: The effects of lactic acid bacteria (LAB) and cellulase enzyme on fermentation quality, microorganism population, chemical composition and in vitro gas production of sorghum silages were studied. Methods: Commercial inoculant Lactobacillus plantarum Chikuso 1 (CH), local selected strain L. casei TH 14 and Acremonium cellulase (AC) were used as additives in sorghum silage preparation. Results: Prior to ensiling Sorghum contained 104 LAB and 106 cfu/g fresh matter coliform bacteria...
May 14, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28727575/surface-energy-tunable-iso-decyl-acrylate-based-molds-for-low-pressure-nano-imprint-lithography
#5
Hyowon Tak, Dongha Tahk, Chanho Jeong, Sori Lee, Tae-Il Kim
We presented surface energy-tunable nanoscale molds for unconventional lithography. The mold is highly robust, transparent, has a minimized haze, does not contain additives, and is a non-fluorinated IDA Isodecyl acrylate (IDA) and Trimethylolpropane Triacrylate (TMPTA) based polymer. By changing the mixing ratio of the polymer components, the cross-linking density, mechanical modulus, and surface energy (crucial factors in low pressure (1~2×105 N/m2) nanoimprint lithography (LP-NIL)), can be controlled. To verify these properties of the molds, we also characterized the surface energy by measuring the contact angles and calculating the work of adhesion among the wafer, polymer film, and mold for successful demolding in nanoscale structures...
July 20, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28727468/effect-of-finishing-procedures-on-the-surface-roughness-of-resin-modified-glass-ionomer-materials
#6
Mohammad Garshasb, Gildo C Santos, Amin S Rizkalla, Richard Bohay, M Jacinta Santos
This study examined the influence of finishing procedures on the surface roughness of different formulations of resin-modified glass ionomers (RMGIs) available in capsules compared with standard resin composites (RCs). Disc samples of three RMGIs and two RCs were fabricated using a metal mold (5 mm x 1.5 mm). Samples were randomly divided into seven groups (N = 10) and subjected to finishing and polishing procedures using a combination of carbide or diamond burs, followed by either rubber points or aluminum-oxide discs...
July 2017: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/28725928/structural-modification-of-cuminaldehyde-thiosemicarbazone-increases-inhibition-specificity-toward-aflatoxin-biosynthesis-and-sclerotia-development-in-aspergillus-flavus
#7
Francesca Degola, Franco Bisceglie, Marianna Pioli, Sabrina Palmano, Lisa Elviri, Giorgio Pelosi, Tiziana Lodi, Francesco Maria Restivo
Aspergillus flavus is an opportunistic mold that represents a serious threat for human and animal health due to its ability to synthesize and release, on food and feed commodities, different toxic secondary metabolites. Among them, aflatoxin B1 is one of the most dangerous since it is provided with a strong cancerogenic and mutagenic activity. Controlling fungal contamination on the different crops that may host A. flavus is considered a priority by sanitary authorities of an increasing number of countries due also to the fact that, owing to global temperature increase, the geographic areas that are expected to be prone to experience sudden A...
July 19, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28725393/water-mold-infection-but-not-paternity-induces-selective-filial-cannibalism-in-a-goby
#8
Martin Vallon, Nils Anthes, Katja U Heubel
Many animals heavily invest in parental care but still reject at least some of their offspring. Although seemingly paradoxical, selection can favor parents to neglect offspring of particularly low reproductive value, for example, because of small survival chances. We here assess whether filial cannibalism (FC), where parents routinely eat some of their own young, is selective in response to individual offspring reproductive value. We performed two independent laboratory experiments in the common goby (Pomatoschistus microps) to test whether caring fathers preferentially cannibalize eggs of a given infection history and paternity...
October 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/28720834/chemical-inhibitors-of-candida-albicans-hyphal-morphogenesis-target-endocytosis
#9
Hagit Bar-Yosef, Nora Vivanco Gonzalez, Shay Ben-Aroya, Stephen J Kron, Daniel Kornitzer
Candida albicans is an opportunistic pathogen, typically found as a benign commensal yeast living on skin and mucosa, but poised to invade injured tissue to cause local infections. In debilitated and immunocompromised individuals, C. albicans may spread to cause life-threatening systemic infections. Upon contact with serum and at body temperature, C. albicans performs a regulated switch to filamentous morphology, characterized by emergence of a germ tube from the yeast cell followed by mold-like growth of branching hyphae...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28719482/teaching-incision-and-drainage-perceived-educational-value-of-abscess-models
#10
Cynthia M Adams, Lise E Nigrovic, Gavin Hayes, Peter H Weinstock, Joshua Nagler
OBJECTIVES: Incision and drainage (I&D) of skin abscesses is an important procedural skill for pediatric emergency medicine providers. Practical skills training using simulation provides an opportunity to learn and gain confidence with this invasive procedure. Our objective was to assess the perceived educational value of 2 versions of an abscess model as part of an educational workshop for teaching I&D. METHODS: A combined didactic and practical skills workshop was developed for use at 2 national conferences...
July 17, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28718709/bioaerosols-concentrations-in-working-areas-in-biomethanization-facilities
#11
Marie-Eve Dubuis, Hamza M'Bareche, Marc Veillette, Bouchra Bakhiyi, Joseph Zayed, Jacques Lavoie, Caroline Duchaine
This study sought to fill the gap in information about the type and the concentration of bioaerosols present in the air of biomethanization facilities (BF). Evaluation of bioaerosol composition and concentration was achieved in two biomethanization facilities located in Eastern Canada, during summer and winter. In order to have a thorough understanding of the studied environment, the methodology combined culture of bacteria and molds, qPCR for specific microorganisms, endotoxin quantification and NGS for bacterial diversity...
July 18, 2017: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/28718329/assessment-of-forearm-rotational-control-using-4-upper-extremity-immobilization-constructs
#12
Ayesha M Rahman, Nicole Montero-Lopez, Richard M Hinds, Michael Gottschalk, Eitan Melamed, John T Capo
BACKGROUND: Forearm immobilization techniques are commonly used to manage distal radius, scaphoid, and metacarpal fractures. The purpose of our study was to compare the degree of rotational immobilization provided by a sugar-tong splint (STS), short arm cast (SAC), Munster cast (MC), and long arm cast (LAC) at the level of the distal radioulnar joint (DRUJ), carpus, and metacarpals. METHODS: Seven cadaveric upper extremity specimens were mounted to a custom jig with the ulnohumeral joint fixated in 90° of flexion...
February 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28713763/evaluation-of-three-different-processing-techniques-in-the-fabrication-of-complete-dentures
#13
Vamsi Krishna Chintalacheruvu, Rajasekaran Uttukuli Balraj, Lavanya Sireesha Putchala, Sreelekha Pachalla
AIMS AND OBJECTIVES: The objective of the present study is to compare the effectiveness of three different processing techniques and to find out the accuracy of processing techniques through number of occlusal interferences and increase in vertical dimension after denture processing. MATERIALS AND METHODS: A cross-sectional study was conducted on a sample of 18 patients indicated for complete denture fabrication was selected for the study and they were divided into three subgroups...
June 2017: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/28713702/evidence-based-efficacy-of-autologous-grated-cartilage-in-primary-and-secondary-rhinoplasty
#14
Ali Manafi, Ali Kaviani, Zahra Sadat Hamedi, Afsaneh Rajabiani, Navid Manafi
BACKGROUND: There are numerous methods to mold and shape cartilage grafts for use in rhinoplasty. Each technique has advantages and disadvantages. We are going to introduce a new method for cartilage shaping with long lasting effects confirmed by follow up examination and pathologic evaluation. METHODS: Grated cartilage was used in 483 patients. For 89 cases, it was wrapped in fascia and in 394 patients, used as a filler per se or in contiguity with solid structural grafts...
May 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/28713400/overexpression-of-e3-ubiquitin-ligase-gene-adbil-contributes-to-resistance-against-chilling-stress-and-leaf-mold-disease-in-tomato
#15
Shuangchen Chen, Hongjiao Zhao, Mengmeng Wang, Jidi Li, Zhonghong Wang, Fenghua Wang, Airong Liu, Golam J Ahammed
Ubiquitination is a common regulatory mechanism, playing a critical role in diverse cellular and developmental processes in eukaryotes. However, a few reports on the functional correlation between E3 ubiquitin ligases and reactive oxygen species (ROS) or reactive nitrogen species (RNS) metabolism in response to stress are currently available in plants. In the present study, the E3 ubiquitin ligase gene AdBiL (Adi3 Binding E3 Ligase) was introduced into tomato line Ailsa Craig via Agrobacterium-mediated method...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28713362/biocontrol-agents-increase-the-specific-rate-of-patulin-production-by-penicillium-expansum-but-decrease-the-disease-and-total-patulin-contamination-of-apples
#16
Xiangfeng Zheng, Qiya Yang, Xiaoyun Zhang, Maurice T Apaliya, Giuseppe Ianiri, Hongyin Zhang, Raffaello Castoria
Synthetic fungicides are commonly employed for the control of postharvest diseases of fruits. However, due to health concerns about the use of these chemicals, alternative control methods including biocontrol based on antagonistic yeasts are gaining in popularity. In this study, we investigated the effects of two biocontrol yeasts, Rhodotorula mucilaginosa strain 3617 and Rhodotorula kratochvilovae strain LS11, on blue mold and patulin (PAT) contamination caused by Penicillium expansum strains PY and FS7 in artificially inoculated Fuji apples stored at 20°C for 9 days...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28713110/an-innovative-approach-to-retention-thermoplastic-retainer
#17
K A Adam Ozeer, Sumitha A David, Umar Mohamed, P C Sunil, Sam Paul, Parson Paul
AIM: The aim of this study was to design and introduce a retainer that overcomes the common shortcomings seen in other retainers. MATERIALS AND METHODS: Hard thermoplastic sheet of 0.5 mm thickness is vacuum or pressure-molded onto the patient cast. Lingual portion of the retainer is trimmed according to the contours of the anterior teeth. Contact points between the maxillary and mandibular anterior teeth are marked on the retainer and reduced. Punch cut holes are placed on the retainer for the exit of flash and air bubbles while fixation...
July 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28712819/clinical-characteristics-radiologic-findings-risk-factors-and-outcomes-of-serum-galactomannan-negative-invasive-pulmonary%C3%A2-aspergillosis
#18
Jiwon Jung, Mi Young Kim, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Sung-Han Kim
BACKGROUND: The sensitivity of galactomannan (GM) assay is suboptimal for detecting invasive pulmonary aspergillosis (IPA) in serum samples. However, the clinical characteristics, radiologic findings, and outcomes in patients with GM-negative IPA have not been fully elucidated. METHODS: Over a 7-year period, adult patients with proven or probable IPA by the EORTC/MSG definition were retrospectively enrolled. Patients with negative GM results and positive Aspergillus spp...
June 29, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28712740/aspects-of-adhesion-tests-on-resin-glass-ceramic-bonding
#19
Andrew Chi Ho Wong, Tian Tian, James Kit Hon Tsoi, Michael Francis Burrow, Jukka Pekka Matinlinna
OBJECTIVES: This study aimed to compare and contrast two resin-ceramic bond strength tests, the tensile bond strength and the four-point bending tests. The effects of hydrofluoric acid (HF) etching time and storage condition on bond strength were also studied. METHODS: Ceramic beams (N=480) with the dimensions of 2.00×2.00×12.45mm(3) were sectioned from lithium disilicate ceramic ingots (IPS e.max CAD), then polished and fired for final crystallization. The joint surfaces were etched with HF gel (IPS Ceramic etching gel) for 20s, 40s, or 60s of each group (n=160)...
July 13, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28712345/post-processing-optimization-of-electrospun-sub-micron-poly-3-hydroxybutyrate-fibers-to-obtain-continuous-films-of-interest-in-food-packaging-applications
#20
A Cherpinski, S Torres-Giner, L Cabedo, J M Lagaron
Polyhydroxyalkanoates (PHAs) are one of the most researched family of biodegradable polymers based on renewable materials due to their thermoplastic nature and moisture resistance. The present study was targeted to investigate the preparation and characterization of poly(3-hydroxybutyrate) (PHB) films obtained through the electrospinning technique. To convert them into continuous films, of interest in for instance packaging, the electrospun fiber mats were subsequently post-processed by different physical treatments to optimize their physical performance...
July 17, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
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