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https://www.readbyqxmd.com/read/28749564/impact-of-sustained-virologic-response-with-direct-acting-antiviral-treatment-on-mortality-in-patients-with-advanced-liver-disease
#1
Lisa I Backus, Pamela S Belperio, Troy A Shahoumian, Larry A Mole
The impact of sustained virologic response (SVR) on mortality after direct-acting antiviral (DAA) treatment is not well documented. This study evaluated the impact of DAA-induced SVR on all-cause mortality and on incident hepatocellular carcinoma (HCC) in 15,059 HCV-infected patients with advanced liver disease defined by a FIB-4 >3.25. Overall, 1,067 patients did not achieve SVR (No SVR) and 13,992 patients achieved SVR. In a mean follow-up period of approximately 1.6 years, 195 No SVR patients and 598 SVR patients died...
July 27, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28749413/pgk1-drives-hepatocellular-carcinoma-metastasis-by-enhancing-metabolic-process
#2
Huijun Xie, Guihui Tong, Yupei Zhang, Shu Liang, Kairui Tang, Qinhe Yang
During the proliferation and metastasis, the tumor cells prefer glycolysis (Warburg effect), but its exact mechanism remains largely unknown. In this study, we demonstrated that phosphoglycerate kinase 1 (PGK1) is an important enzyme in the pathway of metabolic glycolysis. We observed a significant overexpression of PGK1 in hepatocellular carcinoma tissues, and a correlation between PGK1 expression and poor survival of hepatocellular carcinoma patients. Also, the depletion of PGK1 dramatically reduced cancer cell proliferation and metastasis, indicating an oncogenic role of PGK1 in liver cancer progression...
July 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28748353/mir-93-enhances-hepatocellular-carcinoma-invasion-and-metastasis-by-emt-via-targeting-pdcd4
#3
Chunmei Ji, Hang Liu, Qiang Yin, Hui Li, Han Gao
OBJECTIVES: To clarify the potential biological function of miR-93 and its related molecular mechanism underlying metastasis in human hepatocellular carcinoma (HCC). RESULTS: miR-93 was significantly up-regulated in HCC tissues and was associated with poor 5-year overall survival in HCC patients. Transwell assays showed that over-expression of miR-93 increased HCC cell migration and invasion in vitro. Programmed cell death 4 (PDCD4) was a target gene of miR-93 and miR-93 could down-regulate the expression of PDCD4 by directly targeting its 3'-UTR...
July 26, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28747271/diagnostic-accuracy-of-split-bolus-single-phase-contrast-enhanced-cone-beam-ct-for-the-detection-of-liver-tumors-before-transarterial-chemoembolization
#4
Martin Jonczyk, Julius Chapiro, Federico Collettini, Dominik Geisel, Dirk Schnapauff, Florian Streitparth, Thomas Schmidt, Bernd Hamm, Bernhard Gebauer, Gero Wieners
PURPOSE: To evaluate detectability of hepatocellular carcinoma (HCC) using split-bolus cone-beam CT in intraindividual comparison between cone-beam CT and contrast-enhanced MR imaging. MATERIALS AND METHODS: In a retrospective, single-center study, 28 patients with 85 HCC tumors were treated with transarterial chemoembolization between May 2015 and June 2016. All patients underwent arterial and hepatobiliary phase (HBP) MR imaging within 1 month before transarterial chemoembolization...
July 23, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28747084/mir-615-5p-depresses-natural-killer-cells-cytotoxicity-through-repressing-igf-1r-in-hepatocellular-carcinoma-patients
#5
Mai Atef Rahmoon, Rana Ahmed Youness, Asmaa Ibrahim Gomaa, Mohamed Tarif Hamza, Imam Waked, Hend Mohamed El Tayebi, Ahmed Ihab Abdelaziz
miR-615-5p was characterized by our group as a tumour suppressor. IGF-1 R activates a downstream signalling pathway, well characterized in liver cells, however, its role in immunity especially Natural Killer cells (NKs) remains vague. This study aimed at investigating the regulatory role of miR-615-5p on IGF signalling and its impact on NKs cytotoxicity in HCC. Our results showed an upregulation in miR-615-5p and IGF-1 R in NKs of 130 HCC patients compared to 35 controls. Forcing the expression of miR-615-5p, repressed IGF-IR, attenuated NKs cytotoxicity, decreased CD56(dim), increased CD56(bright) NK subsets and reduced the cytotoxic markers NKG2D, TNF-α and perforins...
July 27, 2017: Growth Factors
https://www.readbyqxmd.com/read/28747003/baicalein-a-review-of-its-anti-cancer-effects-and-mechanisms-in-hepatocellular-carcinoma
#6
REVIEW
Beibei Bie, Jin Sun, Ying Guo, Jun Li, Wei Jiang, Jun Yang, Chen Huang, Zongfang Li
Baicalein (5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one) is a flavonoid compound derived from the roots of Scutellaria baicalensis. It has historically been used in anti-oxidant, anti-virus, anti-bacteria, anti-inflammatory and anti-allergic therapies. Recently, baicalein has been found to possess anti-cancer activities via its effect on a variety of biological processes involving cell proliferation, metastasis, apoptosis and autophagy and so on. Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies and high fatality rate worldwide...
July 21, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28746912/transcatheter-hepatic-arterial-chemoembolization-and-sorafenib-for-hepatocellular-carcinoma-a-meta-analysis-of-randomized-double-blind-controlled-trials
#7
Jun Li, Wenhui Liu, Wenhua Zhu, Yinqiao Wu, Benyan Wu
We performed a meta-analysis of transcatheter hepatic arterial chemoembolization (TACE) combined with sorafenib for hepatocellular carcinoma (HCC), which included 4 double-blind, randomized controlled trials (RCTs) that investigated the effects of TACE combined with sorafenib (experimental groups) on time to disease progression (TTP), overall survival (OS), and various sorafenib-related adverse events, compared to those in the placebo (control) groups. A total of 877 HCC cases from 14 countries, including China and the USA, were included in our meta-analysis...
July 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28746790/long-noncoding-rna-tslnc8-is-a-tumor-suppressor-that-inactivates-the-il-6-stat3-signaling-pathway
#8
Jiwei Zhang, Zhe Li, Longzi Liu, Qifeng Wang, Shengli Li, Di Chen, Zhixiang Hu, Tao Yu, Jie Ding, Jinjun Li, Ming Yao, Shenglin Huang, Yingjun Zhao, Xianghuo He
Long noncoding RNAs (lncRNAs) can serve as oncogenes or tumor suppressors in human cancer; however, their biological functions and underlying mechanism in hepatocarcinogenesis are largely unknown. Here, we report a novel tumor suppressor lncRNA on chromosome 8p12 (termed TSLNC8) that is frequently deleted and downregulated in hepatocellular carcinoma (HCC) tissues. The loss of TSLNC8 is highly associated with the malignant features of HCC and serves as a prognostic indicator for HCC patients. TSLNC8 significantly suppresses the proliferation and metastasis of HCC cells in vitro and in vivo...
July 26, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28746788/a-randomized-placebo-controlled-trial-of-prophylactic-dexamethasone-for-transcatheter-arterial-chemoembolization
#9
Sadahisa Ogasawara, Tetsuhiro Chiba, Yoshihiko Ooka, Naoya Kanogawa, Tenyu Motoyama, Eiichiro Suzuki, Akinobu Tawada, Kazue Nagai, Tomoo Nakagawa, Takeshi Sugawara, Hideki Hanaoka, Fumihiko Kanai, Osamu Yokosuka
This randomized, double-blind, placebo-controlled trial evaluated dexamethasone efficacy in preventing fever, anorexia, and nausea/vomiting, the most frequent adverse events of transcatheter arterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC). Child-Pugh class A/B patients with HCC and no macrovascular invasion/extrahepatic metastases were randomly assigned to either a dexamethasone (day 1, intravenous dexamethasone [20 mg] and granisetron [3 mg] before TACE; days 2 and 3, intravenous dexamethasone [8 mg]) or a control regimen (day 1, intravenous placebo [saline] and granisetron [3 mg]; days 2 and 3, intravenous placebo)...
July 26, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28746230/tace-plus-percutaneous-chemotherapy-lipiodol-treatment-of-unresectable-pedunculated-hepatocellular-carcinoma
#10
Dexiao Huang, Yong Chen, Shuo Chen, Qingle Zeng, Jianbo Zhao, Renhua Wu, Yanhao Li
Pedunculated hepatocellular carcinoma (P-HCC) is rare type of HCC. The study aimed to evaluate the clinical features and outcomes of unresectable P-HCC treated with transcatheter arterial chemoembolization (TACE) and percutaneous chemotherapeutic agents lipiodol emulsion (CALE) injection. The clinical features and outcomes of 25 patients with unresectable P-HCC treated with TACE plus percutaneous CALE injection were retrospectively reviewed, and factors associated with outcomes were analyzed. Comparison with nonpedunculated unresectable HCC was also performed...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28746212/intermediate-stage-hepatocellular-carcinoma-patients-with-a-high-hbv-dna-load-may-benefit-from-postoperative-anti-hepatitis-b-virus-therapy
#11
Shaozhen Rui, Jun Yan, Hui Zhang, Zhengfeng Wang, Wence Zhou
Liver resection may be beneficial in intermediate-stage hepatocellular carcinoma (HCC), though the benefit of postoperative anti-hepatitis B virus (HBV) therapy in these patients remains unclear. In this study, we sought to evaluate the efficacy of postoperative anti-HBV for intermediate-stage HCC patients who underwent radical liver resection.According to inclusion and exclusion criteria, this study enrolled 202 HCC patients who underwent liver resection and had a high HBV-DNA load. The patients were divided into 2 groups on the basis of postoperative anti-HBV therapy: group A included patients undergoing postoperative anti-HBV therapy, whereas group B patients did not receive any postoperative anti-HBV therapy...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28746206/association-between-relative-liver-enhancement-on-gadoxetic-acid-enhanced-magnetic-resonance-images-and-histologic-grade-of-hepatocellular-carcinoma
#12
Young-Joo Jin, Soon Gu Cho, Kun Young Lee, Joon Mee Kim, Jin Woo Lee
We evaluated the association between histologic grade of hepatocellular carcinoma (HCC) and degree of HCC enhancement on Gd-EOB-DTPA (Gadoxetic acid, Primovist)-enhanced magnetic resonance images (MRI) in HCC patients.A total of 121 patients who underwent curative surgical resection for HCC at our institution between January 2012 and March 2015 were retrospectively analyzed. Gadoxetic acid enhanced MRI was performed in all patients before surgery. Signal intensities of HCC and peri-HCC areas were measured using regions of interest...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28746200/promising-significance-of-the-association-of-mir-204-5p-expression-with-clinicopathological-features-of-hepatocellular-carcinoma
#13
Yi-Huan Luo, Wei Tang, Xin Zhang, Zhong Tan, Wen-Liang Guo, Na Zhao, Si-Min Pang, Yi-Wu Dang, Min-Hua Rong, Ji Cao
Decreased level of miR-204-5p has been documented in various malignancies. However, the expression and clinical significance of miR-204-5p in hepatocellular carcinoma has not been investigated. The aim of this study is to examine the relationship between miR-204-5p expression and clinicopathological features in hepatocellular carcinoma (HCC) as well as to predict the relevant signaling pathways. The miR-204-5p expression level was detected in HCC and in matched paraneoplastic liver from 95 formalin-fixed paraffin-embedded tissues by the real-time reverse transcription polymerized chain reaction (qRT-PCR)...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28746170/multiple-ectopic-hepatocellular-carcinomas-in-the-pancreas-a-case-report
#14
Zhigui Li, Xiaoting Wu, Tianfu Wen, Chuan Li, Wen Peng
RATIONALE: Ectopic liver tissue can develop at various sites near the liver. Ectopic hepatocellular carcinomas (HCCs) arising from ectopic liver tissue have a rare clinical incidence. A very rare case has been observed to have metastasis after operation. PATIENT CONCERNS: We report an extremely rare case with multiple masses which were identified in the head and body of the pancreas. DIAGNOSES: Ectopic hepatocellular carcinomas. INTERVENTIONS: The masses were removed by surgical resection...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28745399/average-treatment-effect-of-hepatic-resection-versus-locoregional-therapies-for-hepatocellular-carcinoma
#15
A Cucchetti, V Mazzaferro, A D Pinna, C Sposito, R Golfieri, C Serra, C Spreafico, F Piscaglia, A Cappelli, M Bongini, M Cucchi, M Cescon
BACKGROUND: When comparing the efficacy of surgical and non-surgical therapies for hepatocellular carcinoma (HCC), a major limitation is the causal inference problem. This concerns the impossibility of seeing both outcomes of two different treatments for the same individual at the same time because one is inevitably missing. This aspect can be addressed methodologically by estimating the so-called average treatment effect (ATE). METHODS: To estimate the ATE of hepatic resection over locoregional therapies for HCC, data from patients treated in two tertiary care settings between August 2000 and December 2014 were used to obtain counterfactual outcomes using an inverse probability weight survival adjustment...
July 26, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28745317/reticulocalbin-2-enhances-hepatocellular-carcinoma-proliferation-via-modulating-the-egfr-erk-pathway
#16
D Ding, H Huang, W Jiang, W Yu, H Zhu, J Liu, H Saiyin, J Wu, H Huang, S Jiang, L Yu
Hepatocellular carcinoma (HCC) is a major health threat worldwide. Although the involvement of reticulocalbin-2 (RCN2) in cell differentiation has been reported, its function in oncogenesis is poorly understood. Here, we showed that RCN2 was upregulated in tumors compared with adjacent non-tumorous tissues in HCC patients and RCN2 expression clinically correlated with tumor size, disease recurrence and survival rate. Both knockdown and knockout of RCN2 significantly inhibited HCC cell proliferation by inducing G1/S transition arrest and downregulating cyclin D1 expression, while the proliferative ability was restored in knockout HCC cells with exogenously expressed RCN2...
July 24, 2017: Oncogene
https://www.readbyqxmd.com/read/28744835/advantages-of-laparoscopic-radiofrequency-ablation-over-percutaneous-radiofrequency-ablation-in-hepatocellular-carcinoma
#17
Hyuk Soo Eun, Byung Seok Lee, In Sun Kwon, Gee Young Yun, Eaum Seok Lee, Jong Seok Joo, Jae Kyu Sung, Hee Seok Moon, Sun Hyung Kang, Ju Seok Kim, Hae Jin Shin, Tae Kyun Kim, Kwangsik Chun, Seok Hyun Kim
BACKGROUND: Inoperable hepatocellular carcinoma (HCC) can be treated with laparoscopic radiofrequency ablation (LRFA), which is generally a more accurate and accessible procedure than percutaneous RFA (PRFA). However, few studies have compared survival outcomes between LRFA and PRFA in patients with HCC. AIMS: This study aimed to compare the efficacy of LRFA and PRFA for HCC treatment. METHODS: Patients who underwent PRFA or LRFA as an initial treatment modality between April 2005 and April 2016 were enrolled in this study...
July 25, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28743833/therapeutic-vaccine-to-cure-large-mouse-hepatocellular-carcinomas
#18
Zhen Han, De Yang, Anna Trivett, Joost J Oppenheim
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide with limited therapeutic options. Here we report the development of a therapeutic vaccination regimen (shortened as 'TheraVac') consisting of intratumoral delivery of high-mobility group nucleosome-binding protein 1 (HMGN1), R848/resiquimod, and one of the checkpoint inhibitors (e.g. anti-CTLA4, anti-PD-L1, or low dose of Cytoxan). C57BL/6 mice harboring large (approximately 1 cm in diameter) established subcutaneous Hepa1-6 hepatomas were cured by intratumoral injections of TheraVac and became tumor-free long-term survivors...
July 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28743160/the-prognostic-utility-of-baseline-alpha-fetoprotein-for-hepatocellular-carcinoma-patients
#19
Jack P Silva, Richard A Gorman, Nicholas G Berger, Susan Tsai, Kathleen K Christians, Callisia N Clarke, Harveshp Mogal, T Clark Gamblin
INTRODUCTION: Alpha-fetoprotein (AFP) has a valuable role in postoperative surveillance for hepatocellular carcinoma (HCC) recurrence. The utility of pretreatment or baseline AFP remains controversial. The present study hypothesized that elevated baseline AFP levels are associated with worse overall survival in HCC patients. METHODS: Adult HCC patients were identified using the National Cancer Database (2004-2013). Patients were stratified according to baseline AFP measurements into the following groups: Negative (<20), Borderline (20-199), Elevated (200-1999), and Highly Elevated (>2000)...
July 25, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28742983/should-adults-with-diabetes-mellitus-be-vaccinated-against-hepatitis-b-virus-a-systematic-review-of-diabetes-mellitus-and-the-progression-of-hepatitis-b-disease
#20
Zobair Younossi, Katrin Kochems, Marc de Ridder, Desmond Curran, Eveline M Bunge, Laurence de Moerlooze
Despite the burden of diabetes mellitus (DM), little is known about the role of this and other metabolic syndromes on the severity of hepatitis B virus (HBV) chronicity and liver disease progression. The value of hepatitis B vaccination and its impact on liver diseases and HCC has been largely demonstrated (ref), adult vaccination coverage is however suboptimal and DM diagnosis represents an opportunity for the HCP to discuss hepatitis B and other adult vaccinations. We performed a systematic literature search to identify studies (2000 to January 2017) describing liver disease progression among patients with HBV by DM status...
July 25, 2017: Human Vaccines & Immunotherapeutics
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