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https://www.readbyqxmd.com/read/28972892/brain-functional-connectivity-patterns-in-children-and-adolescents-with-gender-dysphoria-sex-atypical-or-not
#1
Nienke M Nota, Baudewijntje P C Kreukels, Martin den Heijer, Dick J Veltman, Peggy T Cohen-Kettenis, Sarah M Burke, Julie Bakker
Various previous studies have reported that brains of people diagnosed with gender dysphoria (GD) show sex-atypical features. In addition, recent functional magnetic resonance imaging studies found that several brain resting-state networks (RSNs) in adults with GD show functional connectivity (FC) patterns that are not sex-atypical, but specific for GD. In the current study we examined whether FC patterns are also altered in prepubertal children and adolescents with GD in comparison with non-gender dysphoric peers...
September 18, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28965587/low-zinc-levels-may-contribute-to-gynecomastia-in-puberty
#2
Pinar Erkekoglu, Erdem Durmaz, Murat Kızılgün, Elif N Özmert, Orhan Derman, Kadriye Yurdakök, Belma Kocer-Gumusel
This study aimed to determine whether there were any differences in trace element levels between adolescent boys with gynecomastia and control boys and to determine the correlations between the levels of trace elements and body mass index (BMI) and sex hormones. The pubertal gynecomastia group comprised of 41 patients (mean age=13.2 ±0.9 years), who were admitted to Hacettepe University İhsan Doğramacı Children's Hospital in Ankara. Control group comprised of 21 healthy male children. Analyses of trace element levels were performed atomic absorption spectrometry...
December 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28960325/the-sex-shift-in-single-disease-and-multimorbid-asthma-and-rhinitis-during-puberty
#3
Theresa Keller, C Hohmann, M Standl, A H Wijga, U Gehring, E Melén, C Almqvist, S Lau, E Eller, U Wahn, E Soegaard Christiansen, A V Berg, J Heinrich, I Lehmann, D Maier, D S Postma, J M Antó, J Bousquet, T Keil, S Roll
BACKGROUND: Cross-sectional studies suggested that allergy prevalence in childhood is higher in boys compared to girls, but it remains unclear if this inequality changes after puberty. We examined the sex-specific prevalence of asthma and rhinitis as single and as multimorbid diseases before and after puberty-onset in longitudinal cohort data. METHODS: In six European population-based birth cohort studies we assessed the outcomes current rhinitis, current asthma, current allergic multimorbidity (i...
September 27, 2017: Allergy
https://www.readbyqxmd.com/read/28926121/new-pediatric-percentiles-of-liver-enzyme-serum-levels-alt-ast-ggt-effects-of-age-sex-bmi-and-pubertal-stage
#4
Sarah Bussler, Mandy Vogel, Diana Pietzner, Kristian Harms, Theresa Buzek, Melanie Penke, Norman Händel, Antje Körner, Ulrich Baumann, Wieland Kiess, Gunter Flemming
The present study aims to clarify the effects of sex, age, BMI and puberty on transaminase serum levels in children and adolescents and to provide new age- and sex-related percentiles for alanine aminotransferase (ALT), aspartate aminotransferase (AST) and γ-glutamyltransferase (GGT). Venous blood and anthropometric data were collected from 4,126 cases. Excluded were cases of participants with potential hepatotoxic medication, with evidence of potential illness at the time of blood sampling and non-normal BMI (BMI < 10(th) or > 90(th) )...
September 19, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28925408/liver-volume-and-hepatic-adiposity-in-childhood-relations-to-body-growth-and-visceral-fat
#5
R Malpique, J Bassols, A López-Bermejo, M Diaz, F Villarroya, J Pavia, A Congo, F de Zegher, L Ibáñez
BACKGROUND AND OBJECTIVE: The sequence of prenatal growth restraint and postnatal catch-up growth may lead to hepato-visceral adiposity, insulin resistance and low-grade inflammation before the onset of puberty. In prepubertal children born appropriate for gestational age (AGA) or small for gestational age (SGA), we assessed potential relationships between the aforementioned sequence and liver volume. SUBJECTS/METHODS: The study population consisted of 86 children (41 AGA and 45 SGA with catch-up growth; age (mean±s...
August 14, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28924487/a-novel-stop-mutation-p-gln22-of-dax1-nr0b1-results-in-late-onset-x-linked-adrenal-hypoplasia-congenita
#6
Judith Gerards, Michael M Ritter, Elke Kaminsky, Andreas Gal, Wolfgang Hoeppner, Marcus Quinkler
DAX1 (NR0B1) is an orphan nuclear receptor, which plays an important role in development and function of the adrenal glands and gonads. Mutations in DAX1 cause X-linked adrenal hypoplasia congenita (X-linked AHC), which is characterized by adrenal insufficiency (AI) and hypogonadotropic hypogonadism (HHG). Affected boys present with adrenal failure usually in childhood and, later in life, with delayed puberty. However, patients with a late-onset form of X-linked AHC have also been described in the past years...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28923047/prepubertal-onset-of-slipped-capital-femoral-epiphysis-associated-with-hypothyroidism-a-case-report-and-literature-review
#7
Saori Kadowaki, Tomohiro Hori, Hideki Matsumoto, Kaori Kanda, Michio Ozeki, Yu Shirakami, Norio Kawamoto, Hidenori Ohnishi, Toshiyuki Fukao
BACKGROUND: Slipped capital femoral epiphysis (SCFE) is a common hip disorder characterized by displacement of the capital femoral epiphysis from the metaphysic through the femoral epiphyseal plate. SCFE usually occurs during puberty, with obesity a common risk factor. We experienced a rare case of SCFE associated with hypothyroidism in a prepubescent patient who was not obese. CASE PRESENTATION: The patient was an 8-year-old boy suffering from bilateral SCFE with hypothyroidism...
September 18, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28915991/adolescent-and-parental-reactions-to-puberty-in-nigeria-and-kenya-a-cross-cultural-and-intergenerational-comparison
#8
Bamidele M Bello, Adesegun O Fatusi, Oluwatomi E Adepoju, Beatrice W Maina, Caroline W Kabiru, Marni Sommer, Kristin Mmari
PURPOSE: This qualitative study assesses the cross-cultural and intergenerational reactions of young adolescents and parents to puberty in Ile-Ife, Nigeria, and Nairobi, Kenya. METHODS: Sixty-six boys and girls (aged 11-13 years) and their parents participated in narrative interviews conducted in English or local languages in two urban poor settings in Ile-Ife and Nairobi. All interviews were recorded, transcribed, translated, and uploaded into Atlas.ti software for coding and analysis...
October 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28912339/reproductive-and-metabolic-features-during-puberty-in-sons-of-women-with-polycystic-ovary-syndrome
#9
Nicolás Crisosto, Bárbara Echiburú, Manuel Maliqueo, Marta Luchsinger, Pedro Rojas, Sergio Recabarren, Teresa Sir-Petermann
CONTEXT: Intrauterine life may be implicated in the origin of polycystic ovary syndrome (PCOS) modifying the endocrine and metabolic functions of children born to PCOS mothers independently of the genetic inheritance and gender. The aim of the present study was to evaluate the reproductive and metabolic functions in sons of women with PCOS during puberty. METHODS: Sixty-nine PCOS sons (PCOSs) and 84 control sons of 7-18 years old matched by the Tanner stage score were studied...
November 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28902184/the-relationship-between-infancy-growth-rate-and-the-onset-of-puberty-in-both-genders
#10
Banu Kucukemre Aydin, Esra Devecioglu, Alev Kadioglu, Ayca Erkin Cakmak, Sezin Kisabacak, Gulbin Gokcay, Firdevs Bas, Sukran Poyrazoglu, Ruveyde Bundak, Feyza Darendeliler
BackgroundIn this study, we examined the hypothesis that weight gain and linear growth during the first years of life influence the onset of puberty both in girls and in boys.MethodsA cohort of 157 healthy children, aged 6-9 years, was evaluated and their growth patterns were analyzed retrospectively. Repeated measures mixed model was used to examine the longitudinal anthropometric data.ResultsGirls with pubertal signs were heavier than their peers starting at 9 months of age (P=0.02), and the difference became more evident over time (P<0...
September 13, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28890442/marked-geographic-patterns-in-the-incidence-of-idiopathic-central-precocious-puberty-a-nationwide-study-in-france
#11
Joëlle Le Moal, Annabel Rigou, Alain Le Tertre, Perrine Decrouy-Chanel, Juliane Leger, Jean-Claude Carel
OBJECTIVES: Precocious puberty seems to be increasing but epidemiological data are scarce. Our objective was to improve the epidemiologic knowledge on this disease, in the context of a suspected role of endocrine disruptor chemicals exposure. We analyzed the national incidence and spatial trends of idiopathic central precocious puberty in France in 2011-2013 in a cross-sectional descriptive study. DESIGN: We used an indicator based on treatment reimbursements recorded in the national insurance database, in boys less than 10 years and girls less than nine years old...
September 10, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28888750/primary-mediastinal-pure-seminomatous-germ-cell-tumor-germinoma-as-a-rare-cause-of-precocious-puberty-in-a-9-year-old-patient
#12
Alejandra Bravo-Balado, Lynda Torres Castellanos, Adriana Carrillo Rodríguez, Daniel Gómez Zapata, Juan Javier Lammoglia Hoyos, Rafael Andrade, Jaime Pérez Niño
Less than 5-7% of germ cell tumors (GCTs) are extragonadal, being the central nervous system (CNS) the most common location in children, followed by retroperitoneum and mediastinum. Only 10% of mediastinal tumors are malignant and one third of these are pure seminomas (germinomas). We report the case of a 9 year-old boy with development of secondary sexual characteristics. Beta human chorionic gonadotropin (B-hCG) was elevated and a mediastinal mass was found. Final histology showed a pure seminomatous germ cell tumor (SGCT)...
September 6, 2017: Urology
https://www.readbyqxmd.com/read/28881543/-associations-between-overweight-obesity-and-puberty-timing-in-children-with-different-genders-in-china
#13
Y Y Xu, L Sun, X Guo, J Zhang, X M Lou, H Wang, F B Tao
Objective: To understand the associations between overweight-obesity and puberty timing in children with different genders. Methods: The girls in grade 2, 3, 7, 8 and boys in grade 3, 4, 7, 8 were recruited from primary and middle schools in North new area of Shenyang, Yanqing district of Beijing, Erqi district of Zhengzhou and Jiulongpo district of Chongqing by purposive sampling method between October and December 2014, respectively. The information of demographic characteristics of the respondents were collected and the pubertal development status was evaluated by Pubertal Development Scale (PDS)...
September 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28872422/bone-turnover-markers-and-lean-mass-in-pubescent-boys-comparison-between-elite-soccer-players-and-controls
#14
Ammar Nebigh, Mohamed Elfethi Abed, Rihab Borji, Sonia Sahli, Slaheddine Sellami, Zouhair Tabka, Haithem Rebai
The aim of this study was to examine the relationship between bone mass and bone turnover markers with lean mass (LM) in pubescent soccer players. Two groups participated in this study, which included 65 elite young soccer players who trained for 6-8 hours per week and 60 controls. Bone mineral density; bone mineral content in the whole body, lower limbs, lumbar spine, and femoral neck; biochemical markers of osteocalcin; bone-specific alkaline phosphatase; C-telopeptide type I collagen; and total LM were assessed...
October 17, 2017: Pediatric Exercise Science
https://www.readbyqxmd.com/read/28859208/height-increment-and-laboratory-profile-of-boys-treated-with-aromatase-inhibitors-with-or-without-growth-hormone
#15
Ludmila Fernandes Pedrosa, Joice Marquez de Oliveira, Paula Roberta Vieira Thomé, Cristiane Kochi, Durval Damiani, Carlos Alberto Longui
Aromatase inhibitors (AIs) have been used to recover height loss due to their capacity to delay growth plate closure. Long-term studies describing final heights are needed to determine the efficacy and safety profiles of these drugs for the treatment of impaired growth. This study aims to identify the therapeutic efficiency of AIs in improve growth and to describe potential adverse effects during treatment. Retrospective data analysis of 96 adolescents, among which 22 patients already attained near-final height, were followed at outpatient clinics of two referral centers...
October 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28856494/typical-pubertal-timing-in-an-australian-population-of-girls-and-boys-with-autism-spectrum-disorder
#16
Tamara May, Ken C Pang, Michele A O'Connell, Katrina Williams
Secondary data analyses from the Longitudinal Study of Australian Children Kindergarten cohort were performed to understand any alterations in pubertal timing in Autism Spectrum Disorder (ASD) in a population sample. Timing of parent-reported pubertal events (ages 8-9, 10-11, 12-13 years), and self-report (14-15 years; N = 3454 no ASD, N = 94 with ASD) included breast development, menses, skin changes, growth spurt, body hair, deepening voice and facial hair. Survival analyses and Cox regression controlling for covariates showed no evidence of altered pubertal onset amongst males with ASD...
August 30, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28837909/age-sex-and-gonadal-hormones-differently-influence-anxiety-and-depression-related-behavior-during-puberty-in-mice
#17
Josiah R Boivin, David J Piekarski, Jessica K Wahlberg, Linda Wilbrecht
Anxiety and depression symptoms increase dramatically during adolescence, with girls showing a steeper increase than boys after puberty onset. The timing of the onset of this sex bias led us to hypothesize that ovarian hormones contribute to depression and anxiety during puberty. In humans, it is difficult to disentangle direct effects of gonadal hormones from social and environmental factors that interact with pubertal development to influence mental health. To test the role of gonadal hormones in anxiety- and depression-related behavior during puberty, we manipulated gonadal hormones in mice while controlling social and environmental factors...
August 12, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28821292/the-relationship-between-obesity-and-body-compositions-with-respect-to-the-timing-of-puberty-in-chongqing-adolescents-a-cross-sectional-study
#18
Fang He, Peiyu Guan, Qin Liu, Donna Crabtree, Linli Peng, Hong Wang
BACKGROUND: It is well known that excess adiposity during childhood may influence pubertal development. However, the extent to which body compositions vary in throughout puberty in boys and girls is currently unknown. The aim of this study was to investigate whether obesity and body compositions correlate with the timing of puberty in boys and girls. METHODS: By random cluster sampling, our study analyzed data from 1472 students (690 girls, 782 boys) aged 6-17 years from two schools in the Chongqing area...
August 18, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28795206/children-and-adolescents-with-cystic-fibrosis-display-moderate-bone-microarchitecture-abnormalities-data-from-high-resolution-peripheral-quantitative-computed-tomography
#19
C Braun, J Bacchetta, P Braillon, R Chapurlat, J Drai, P Reix
We investigated whether bone microstructure assessed by high-resolution peripheral quantitative tomography (HR-pQCT) could be altered in children and teenagers with cystic fibrosis (CF). In comparison to their healthy counterparts, bone microstructure was mildly affected at the tibial level only. INTRODUCTION: Cystic fibrosis-related bone disease (CFBD) may alter bone health, ultimately predisposing patients to bone fractures. Our aim was to assess bone microstructure using high-resolution peripheral quantitative tomography (HR-pQCT) in a cohort of children and teenagers with CF in comparison to age-, puberty-, and gender-matched healthy volunteers (HVs)...
August 9, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28771561/fitness-and-food-environments-around-junior-high-schools-in-taiwan-and-their-association-with-body-composition-gender-differences-for-recreational-reading-food-and-beverage-exposures
#20
Po-Huang Chiang, Lin-Yuan Huang, Meei-Shyuan Lee, Hui-Chen Tsou, Mark L Wahlqvist
School environments may contribute to adolescent behavior, reproductive physiology and body composition (BC). The Nutritional and Health Survey in Taiwan (2010) for 1458 junior high school students was geo-mapped for 30 school environs. Facilities for physical activity (fitness centers, gymnasia and sports stadiums, activity centers and parks), sedentary activities (reading material rental shops (RMRS), internet cafes) and food and beverage outlets (FBOs) were calculated as weighted numbers within 1000m of schools...
2017: PloS One
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