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https://www.readbyqxmd.com/read/28706730/body-mass-index-associations-between-mother-and-offspring-from-birth-to-age-18-the-fels-longitudinal-study
#1
S Swanton, A C Choh, M Lee, L L Laubach, J K Linderman, S A Czerwinski, M J Peterson
BACKGROUND: Parental obesity is a known determinant of childhood obesity. Previous research has shown a strong maternal influence on body mass index (BMI) during infancy and early childhood. OBJECTIVES: The purpose of this research was to investigate the BMI associations between mother and offspring from birth to age 18 years. METHODS: Participants were selected from the Fels Longitudinal Study. The current study sample includes 427 (215 mother/son and 212 mother/daughter) mother/child pairs...
June 2017: Obesity Science & Practice
https://www.readbyqxmd.com/read/28700985/genes-involved-in-long-term-memory-are-expressed-in-testis-of-cryptorchid-boys-and-respond-to-gnrha-treatment
#2
Faruk Hadziselimovic, Katharina Gegenschatz-Schmid, Gilvydas Verkauskas, Philippe Demougin, Vytautas Bilius, Darius Dasevicius, Michael B Stadler
It has been known for many years that boys with unilateral or bilateral undescended testis (cryptorchidism) tend to have a low IQ, and those who belong to the high infertility risk (HIR) group perform less well at school than low infertility risk (LIR) patients. However, the molecular biological processes underlying this phenomenon are not understood. In this study, we report the outcome of testicular RNA profiling for genes involved in long-term memory formation. We analyzed the histology and the transcriptome of testicular biopsies from bilateral HIR cryptorchid boys, comparing those who received GnRHa treatment for 6 months after the first surgery with those who did not receive GnRHa before the second surgery...
July 13, 2017: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/28699265/effects-of-harsh-parenting-and-positive-parenting-practices-on-youth-aggressive-behavior-the-moderating-role-of-early-pubertal-timing
#3
Frances R Chen, Adrian Raine
Prior research indicates that early pubertal timing is associated with aggressive behavior, particularly in the context of adversity as postulated in the contextual amplification hypothesis. However, few studies have examined harsh parenting as the context for the effect of early pubertal timing. Even fewer studies have tested the interactive effect of early pubertal timing and positive parenting on aggressive behavior. In this study, we tested the proposition that early pubertal timing, contrary to the general conception of it as a vulnerability, indexed susceptibility, and thus early maturing individuals were affected more by their environment in a "for better and for worse" manner...
July 12, 2017: Aggressive Behavior
https://www.readbyqxmd.com/read/28695484/use-of-testosterone-gel-compared-to-intramuscular-formulation-for-puberty-induction-in-males-with-constitutional-delay-of-growth-and-puberty-a-preliminary-study
#4
Laura Chioma, Giulia Papucci, Danilo Fintini, Marco Cappa
PURPOSE: Constitutional delay of growth and puberty (CDGP) treatment include observation or therapy with intramuscular testosterone (IMTT). No data are available about transdermal testosterone gel (TTG). The aim of our study was to analyze the use of TTG in males with CDGP. METHODS: 73 boys with CDGP were divided into three groups: IMTT treated with 50 mg i.m. testosterone; TTG with 10 mg daily 2% testosterone transdermal gel, and no treatment (CNT). All subjects were observed at baseline and after 6 months...
July 10, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28691847/expanding-the-developmental-boundaries-of-etiologic-effects-the-role-of-adrenarche-in-genetic-influences-on-disordered-eating-in-males
#5
Kristen M Culbert, S Alexandra Burt, Kelly L Klump
Genetic influences on disordered eating (DE) increase across age and puberty in girls, an effect that is at least partially due to ovarian hormone activation. However, development shifts in genetic effects have not been detected in boys; genetic influences have been found to be relatively constant from prepuberty to adulthood, suggesting that gonadal hormones may be less important. One caveat is that studies have examined males ages 10 or older. Genetic effects on DE may emerge earlier in boys, such as during adrenarche, when androgens begin to increase but the physical changes of puberty are not yet observable...
July 2017: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/28660406/evaluation-of-potentially-prolactin-related-adverse-events-and-sexual-maturation-in-adolescents-with-schizophrenia-treated-with-paliperidone-extended-release-er-for-2-years-a-post-hoc-analysis-of-an-open-label-multicenter-study
#6
Srihari Gopal, Rosanne Lane, Isaac Nuamah, Margaret Copenhaver, Jaskaran Singh, David Hough, Mark Bach, Adam Savitz
BACKGROUND: Elevated prolactin levels (hyperprolactinemia) are a frequent adverse effect of antipsychotic medications, especially in young populations. Prolonged hyperprolactinemia may affect sexual functioning and the onset and progression of puberty. OBJECTIVE: This study assessed potentially prolactin-related treatment-emergent adverse events (PPRL-TEAEs) and sexual maturation during long-term treatment of adolescents with paliperidone extended-release (ER). METHODS: This post hoc analysis of a 2-year open-label multicenter study (NCT00488319) included patients of either sex aged 12-17 years at study enrollment, diagnosed with schizophrenia (Diagnostic and Statistical Manual of Mental Disorders, 4th edition [DSM-IV]) for ≥1 year, who had received one or more adequate antipsychotic treatment prior to enrollment but had not responded sufficiently...
June 28, 2017: CNS Drugs
https://www.readbyqxmd.com/read/28659579/sex-hormones-gonadotropins-and-sex-hormone-binding-globulin-in-infants-fed-breast-milk-cow-milk-formula-or-soy-formula
#7
Xin Fang, Lei Wang, Chunhua Wu, Huijing Shi, Zhijun Zhou, Scott Montgomery, Yang Cao
Measurement of endogenous hormones in early life is important to investigate the effects of hormonally active environmental compounds. To assess the possible hormonal effects of different feeding regimens in different sample matrices of infants, 166 infants were enrolled from two U.S hospitals between 2006 and 2009. The children were classified into exclusive soy formula, cow milk formula or breast milk regimens. Urine, saliva and blood samples were collected over the first 12 months of life. Estradiol, estrone, testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH) and sex hormone-binding globulin (SHBG) levels were measured in the three matrices...
June 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28651391/-prevalence-of-myopia-and-increase-trend-in-children-and-adolescents-aged-7-18-years-in-han-ethnic-group-in-china-2005-2014
#8
Y H Dong, H B Liu, Z H Wang, Z P Yang, R B Xu, Z G Yang, J Ma
Objective: To understand and evaluate the prevalence of myopia and its trend in children and adolescents aged 7-18 years in Han ethnic group in China from 2005 to 2014, and provide evidence for the prevention of myopia. Methods: The data of 2005, 2010 and 2014 Chinese National Students Constitution and Health Surveys were collected. The children and adolescents with complete detection data of binoculus were selected as study subjects. The sample size of three studies were 233 108, 215 319 and 212 743, respectively...
May 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28647951/complexities-of-care-in-klinefelter-syndrome-an-aprn-perspective
#9
Sharron Close, Amy Talboy, Ilene Fennoy
47,XXY (Klinefelter Syndrome) is associated with a spectrum of complex clinical needs that are associated with variable physical, neurocognitive and psychosocial aspects. For patients and families affected by this sex chromosome trisomy, navigation of health care services is difficult due to lack of 47,XXY awareness among many health care providers and little evidence to support endocrine and additional treatment plans. While endocrine management of androgen deficiency has been the mainstay of treatment for patients from puberty through adulthood, testosterone replacement, alone, fails to mitigate many symptoms and issues...
June 2017: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28641572/a-child-with-hypertension-and-ambiguous-genitalia-an-uncommon-variant-of-congenital-adrenal-hyperplasia-a-case-report
#10
Vivek Pant, Suman Baral, Bishal Shrestha, Arjun Tumbapo
BACKGROUND: Deficiency in 11β-hydroxylase as a cause of congenital adrenal hyperplasia is uncommon. It should be considered in the differential diagnosis of hypertension with virilization in any prepubescent child. CASE PRESENTATION: A 12-year-old Asian boy from eastern Nepal presented with pain in his abdomen and hypertension. He was raised as a male but had absent testicles since birth and had precocious puberty. Plasma testosterone, follicle-stimulating hormone, and luteinizing hormone were below baseline level...
June 23, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28613046/anti-mullerian-hormone-amh-determinations-in-the-pediatric-and-adolescent-endocrine-practice
#11
Amir Weintraub, Talia Eldar-Geva
Anti-Mullerian hormone (AMH), secreted by immature testicular Sertoli-cells, triggers the regression of male fetal Mullerian ducts. During puberty, AMH is downregulated by intratesticular testosterone. In females, AMH is secreted from granulosa cells of immature ovarian follicles from late prenatal life until menopause; serum concentration is 5-20 times lower in females than in males through lifetime. In boys, AMH determination is useful in the clinical setting as a marker of Sertoli cell function. Serum AMH is low in infants with hypogonadotrophic hypogonadism (and increases with FSH treatment), in patients with primary hypogonadism from early postnatal life and in Klinefelter syndrome from midpuberty...
June 2017: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28608742/pediatric-onset-multiple-sclerosis-and-other-acquired-demyelinating-syndromes-of-the-central-nervous-system-in-denmark-during-1977-2015-a-nationwide-population-based-incidence-study
#12
Magnus Spangsberg Boesen, Melinda Magyari, Nils Koch-Henriksen, Lau Caspar Thygesen, Alfred Peter Born, Peter Vilhelm Uldall, Morten Blinkenberg
BACKGROUND: The incidence of acquired demyelinating syndromes (ADS) including multiple sclerosis (MS) has never been investigated in a Danish pediatric population. OBJECTIVES: We estimated the nationwide age- and sex-specific incidence of pediatric ADS including MS. METHODS: Data were sourced from the Danish Multiple Sclerosis Registry, providing cases of pediatric MS for 1977-2015, and the National Patient Register, providing cases of ADS during 2008-2015...
June 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28604756/anthropometry-dxa-and-leptin-reflect-subcutaneous-but-not-visceral-abdominal-adipose-tissue-by-mri-in-197-healthy-adolescents
#13
Jeanette Tinggaard, Casper P Hagen, Anders N Christensen, Annette Mouritsen, Mikkel G Mieritz, Christine Wohlfahrt-Veje, Jørn W Helge, Thomas N Beck, Eva Fallentin, Rasmus Larsen, Rikke B Jensen, Anders Juul, Katharina M Main
BACKGROUND: Abdominal fat distribution is associated with development of cardio-metabolic disease, independently of BMI. We assessed anthropometry, serum adipokines and DXA as markers of abdominal subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) by MRIMETHODS:We performed a cross-sectional study including 197 healthy adolescents (114 boys) aged 10-15 years nested within a longitudinal population-based cohort. Clinical examination, blood sampling, DXA and abdominal MRI was performed...
June 12, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28591479/hypothalamic-hamartoma-with-epilepsy-review-of-endocrine-comorbidity
#14
REVIEW
Victor S Harrison, Oliver Oatman, John F Kerrigan
The most common, and usually the only, endocrine disturbance in patients with hypothalamic hamartoma (HH) and epilepsy is central precocious puberty (CPP). The mechanism for CPP associated with HH may relate to ectopic generation and pulsatile release of gonadotropin-releasing hormone (GnRH) from the HH, but this remains an unproven hypothesis. Possible regulators of GnRH release that are intrinsic to HH tissue include the following: (1) glial factors (such as transforming growth factor α[TGFα) and (2) γ-aminobutyric acid (GABA)-mediated excitation...
June 2017: Epilepsia
https://www.readbyqxmd.com/read/28590266/sex-differences-in-aortic-augmentation-index-in-adolescents
#15
Jennifer Y Barraclough, Frances L Garden, Brett Toelle, Shamus O'Meagher, Guy B Marks, Christopher T Cowell, David S Celermajer, Julian G Ayer
BACKGROUND: Augmentation index (AIx) is a noninvasive measure of pulse wave reflection. AIx is associated with cardiovascular disease. Adult women have a higher AIx than men, but the factors determining this sex-related difference remain to be determined. METHODS: To examine factors associated with AIx in adolescents, participants in the Childhood Asthma Prevention Study, followed from birth, were assessed at age 14 years, with AIx standardized to a heart rate of 75/min (AIx_75) and pulse wave velocity...
June 5, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28580516/indian-girls-have-higher-bone-mineral-content-per-unit-of-lean-body-than-boys-through-puberty
#16
Anuradha V Khadilkar, Neha Sanwalka, M Zulf Mughal, Shashi Chiplonkar, Vaman Khadilkar
Our aim is to describe changes in the muscle-bone unit assessed as a ratio of bone mineral content (BMC) to lean body mass (LBM) through puberty at total body and various skeletal sites in Indian boys and girls. A cross-sectional study was conducted (888 children, 480 boys, aged 5-17 years) in Pune, India. Pubertal staging was assessed. BMC, LBM and fat percentage at the arms, legs, android, gynoid and total body (less the head) were assessed by dual energy X-ray absorptiometry. The amount of BMC per unit LBM (BMC/LBM) was computed...
June 3, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/28562276/childhood-social-disadvantage-and-pubertal-timing-a-national-birth-cohort-from-australia
#17
Ying Sun, Fiona K Mensah, Peter Azzopardi, George C Patton, Melissa Wake
BACKGROUND AND OBJECTIVES: Early pubertal timing is linked with a range of adverse health outcomes later. Given recent trends of earlier pubertal maturation, there is growing interest in the factors influencing pubertal timing. Socioeconomic disadvantage has been previously linked with reproductive strategies later in life. In this study, we aim to determine the association between cumulative social disadvantages in early life and early puberty in a population-based birth cohort. METHODS: Data are from the B (baby) cohort of The Longitudinal Study of Australian Children...
May 23, 2017: Pediatrics
https://www.readbyqxmd.com/read/28562261/early-puberty-friendship-group-characteristics-and-dating-abuse-in-us-girls
#18
Frances R Chen, Emily F Rothman, Sara R Jaffee
OBJECTIVES: The current study aimed to investigate the relationship between advanced pubertal development and adolescent dating abuse (ADA) and to test if this relationship is moderated by friendship group characteristics in a nationally representative sample of US girls. METHODS: Data were drawn from wave 1 and 2 (1995-1996) of the National Longitudinal Study of Adolescent to Adult Health. The sample included 3870 girls aged 13 to 17 years, all of whom were in romantic and/or nonromantic sexual relationships...
May 8, 2017: Pediatrics
https://www.readbyqxmd.com/read/28558376/long-term-outcomes-of-patients-with-central-precocious-puberty-due-to-hypothalamic-hamartoma-after-gnrh-analog-treatment-anthropometric-metabolic-and-reproductive-aspects
#19
Carolina O Ramos, Ana C Latronico, Priscilla Cukier, Delanie B Macedo, Danielle S Bessa, Marina C Silva, Ivo J Arnhold, Berenice B Mendonca, Vinicius N Brito
CONTEXT: Hypothalamic hamartoma (HH) represents the commonest cause of organic central precocious puberty (CPP). Follow-up of these patients at adulthood are scarce. OBJECTIVE: To describe the anthropometric, metabolic and reproductive parameters of patients with CPP due to HH before and after treatment with gonadotropin-releasing hormone analog (GnRHa). DESIGN: Retrospective and cross-sectional study. SETTING: Single tertiary center...
May 30, 2017: Neuroendocrinology
https://www.readbyqxmd.com/read/28553601/pubertal-onset-in-apparently-healthy-indian-boys-and-impact-of-obesity
#20
Vineet Surana, Aashima Dabas, Rajesh Khadgawat, Raman Kumar Marwaha, V Sreenivas, M Ashraf Ganie, Nandita Gupta, Neena Mehan
OBJECTIVE: Primary - to determine the age of pubertal onset in Indian boys. Secondary - (a) to assess the impact of obesity on pubertal timing, (b) to assess the relationship between gonadotropins and puberty. DESIGN: Cross-sectional. SETTING: General community-seven schools across New Delhi. PARTICIPANTS: Random sample of 1306 school boys, aged 6-17 years. MATERIALS AND METHODS: Anthropometric measurement for weight and height and pubertal staging was performed for all subjects...
May 2017: Indian Journal of Endocrinology and Metabolism
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