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https://www.readbyqxmd.com/read/29669934/divergent-responses-to-kisspeptin-in-children-with-delayed-puberty
#1
Yee-Ming Chan, Margaret F Lippincott, Temitope O Kusa, Stephanie B Seminara
BACKGROUND: The neuropeptide kisspeptin stimulates luteinizing hormone (LH) secretion in healthy adults but not in adults with idiopathic hypogonadotropic hypogonadism. We hypothesized that, in children presenting with delayed or stalled puberty, kisspeptin would elicit LH secretion in those children found on detailed nighttime neuroendocrine profiling to have evidence of emerging reproductive endocrine function. METHODS: Eleven boys and four girls were admitted overnight to assess LH secretion at baseline, after a single intravenous bolus of kisspeptin, and after a single intravenous bolus of gonadotropin-releasing hormone (GnRH)...
April 19, 2018: JCI Insight
https://www.readbyqxmd.com/read/29669435/optimal-design-for-longitudinal-studies-to-estimate-pubertal-height-growth-in-individuals
#2
Tim James Cole
BACKGROUND: The SITAR model expresses individual pubertal height growth in terms of mean size, peak height velocity (PHV) and age at PHV. AIM: To use SITAR to identify the optimal time interval between measurements to summarise individual pubertal height growth. SUBJECTS AND METHODS: Heights in 3172 boys aged 9-19 years from Christ's Hospital School measured on 128 679 occasions (a median of 42 heights per boy) were analysed using the SITAR (SuperImposition by Translation And Rotation) mixed effects growth curve model, which estimates a mean curve and three subject-specific random effects...
April 18, 2018: Annals of Human Biology
https://www.readbyqxmd.com/read/29663652/a-longitudinal-study-of-serum-insulin-like-growth-factor-i-igf-i-levels-over-six-years-in-a-large-cohort-of-children-and-adolescents-with-type-1-diabetes-mellitus-a-marker-reflecting-diabetic-retinopathy
#3
Daniel Öberg, Jenny Salemyr, Eva Örtqvist, Anders Juul, Peter Bang
OBJECTIVE: To evaluate longitudinal serum IGF-I in a large cohort of children and adolescents with type 1 diabetes in relation to HbA1c, age, diabetes duration, and BMI, its association to height and retinopathy, and in comparison with healthy subject references. RESEARCH DESIGN AND METHODS: A total of 2,683 serum IGF-I values were obtained from 806 children and adolescents with T1DM, from annual blood samples for up to 6 consecutive years. RESULTS: In a multiple regression analysis IGF-I values were negatively correlated to HbA1c and diabetes duration, and positively correlated to BMI (p<0...
April 16, 2018: Pediatric Diabetes
https://www.readbyqxmd.com/read/29659920/chromosome-14q32-2-imprinted-region-disruption-as-an-alternative-molecular-diagnosis-of-silver-russell-syndrome
#4
Sophie Geoffron, Walid Abi Habib, Sandra Chantot-Bastaraud, Béatrice Dubern, Virginie Steunou, Salah Azzi, Alexandra Afenjar, Tiffanny Busa, Ana P Canton, Christel Chalouhi, Marie-Noëlle Dufourg, Blandine Esteva, Mélanie Fradin, David Geneviève, Solveig Heide, Bertrand Isidor, Agnès Linglart, Fanny Morice Picard, Catherine Naud-Saudreau, Isabelle Oliver Petit, Nicole Philip, Catherine Pienkowski, Marlène Rio, Sylvie Rossignol, Maithé Tauber, Julien Thevenon, Thuy-Ai Vu-Hong, Madeleine D Harbison, Jennifer Salem, Frédéric Brioude, Irène Netchine, Eloïse Giabicani
Context: Silver-Russell syndrome (SRS) (mainly secondary to 11p15 molecular disruption) and Temple syndrome (TS) (secondary to 14q32.2 molecular disruption) are imprinting disorders with phenotypic (prenatal and postnatal growth retardation, early feeding difficulties) and molecular overlap. Objective: To describe the clinical overlap between SRS and TS and extensively study the molecular aspects of TS. Patients: We retrospectively collected data on 28 patients with disruption of the 14q32...
April 11, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29629701/peripheral-precocious-puberty-caused-by-human-chorionic-gonadotropin-producing-pineal-gland-tumor
#5
S K Hammadur Rahaman, Deepak Khandelwal, Rajesh Khadgawat, Devasenathipathy Kandasamy, Sameer Bakhshi
BACKGROUND: Pineal gland lesions usually present with central precocious puberty. CASE CHARACTERISTICS: A 3½-yr-old boy presented with precocious puberty. Clinically and biochemically, it was gonadotropin releasing hormone (GnRH) independent. Serum and CSF beta-hCG levels were increased. Thin section magnetic resonance imaging of brain revealed a pineal gland tumor. OUTCOME: He received chemotherapy followed by radiotherapy and responded well...
March 15, 2018: Indian Pediatrics
https://www.readbyqxmd.com/read/29614125/the-prevalence-of-brain-abnormalities-in-boys-with-central-precocious-puberty-may-be-overestimated
#6
Jong Seo Yoon, Cheol Hwan So, Hae Sang Lee, Jung Sub Lim, Jin Soon Hwang
Brain magnetic resonance imaging (MRI) is routinely performed to identify brain lesions in boys with central precocious puberty (CPP). We investigated the prevalence of CPP in Korean boys and the necessity for routine brain MRI examinations. This retrospective cross-sectional study was conducted from April 2003 to December 2016 at a Korean university hospital. Among 151 boys who were diagnosed with CPP, the data of 138 boys who underwent sellar MRI were evaluated. The mean age of the study subjects was 9.51 ± 0...
2018: PloS One
https://www.readbyqxmd.com/read/29599748/polyostotic-fibrous-dysplasia-with-and-without-mccune-albright-syndrome-clinical-features-in-a-nordic-pediatric-cohort
#7
Pauliina Utriainen, Helena Valta, Sigridur Björnsdottir, Outi Mäkitie, Eva Horemuzova
Objective: Fibrous dysplasia (FD) presents as skeletal lesions in which normal bone is replaced by abnormal fibrous tissue due to mosaic GNAS mutation. McCune-Albright syndrome (MAS) refers to FD combined with skin (café-au-lait) and endocrine manifestations. This study describes the clinical childhood manifestations of polyostotic FD and MAS in a Nordic cohort. Patients and design: We retrospectively reviewed a cohort of pediatric patients ( n  = 16) with polyostotic FD with or without MAS diagnosed and followed in two Nordic Pediatric tertiary clinics between 1996 and 2017...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29593790/association-between-dietary-patterns-and-precocious-puberty-in-children-a-population-based-study
#8
Chang Chen, Yao Chen, Yunting Zhang, Wanqi Sun, Yanrui Jiang, Yuanjin Song, Qi Zhu, Hao Mei, Xiumin Wang, Shijian Liu, Fan Jiang
Objective: The aim of the present study was to investigate the association between dietary patterns and precocious puberty among Shanghai children. Methods: A cross-sectional study was conducted among Shanghai children by multistage stratified cluster random sampling in June 2014. Diet was assessed using a simplified food frequency questionnaire (FFQ). Height, weight, and Tanner stages of breast development, pubic hair growth, and testicular volume were carefully measured...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29557627/-atypical-presentation-of-a-giant-prolactinoma-in-a-15-year-old-boy
#9
Elisa Vaiani, Cintia Morales, Florencia Soto, Yeny Blanco, Carlos Rugilo, Marta Ciaccio, Alicia Belgorosky
Giant prolactinomas are rare pituitary adenomas characterized by their great local invasion. In this paper, we report a 15-year-old male with left retro-ocular pain and ipsilateral exophthalmos of 4 months of evolution, secondary to a tumour in the base of the skull that invaded the orbit. Hormonal studies revealed serum prolactin of 6913,7 ng/ml (normal value < 20), confirming the diagnosis of giant prolactinoma. The patient started treatment with the dopaminergic agonist cabergoline in increasing doses...
April 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29556038/modelling-3d-craniofacial-growth-trajectories-for-population-comparison-and-classification-illustrated-using-sex-differences
#10
Harold S Matthews, Anthony J Penington, Rita Hardiman, Yi Fan, John G Clement, Nicola M Kilpatrick, Peter D Claes
Many disorders present with characteristic abnormalities of the craniofacial complex. Precise descriptions of how and when these abnormalities emerge and change during childhood and adolescence can inform our understanding of their underlying pathology and facilitate diagnosis from craniofacial shape. In this paper we develop a framework for analysing how anatomical differences between populations emerge and change over time, and for binary group classification that adapts to the age of each participant. As a proxy for a disease-control comparison we use a database of 3D photographs of normally developing boys and girls to examine emerging sex-differences...
March 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29555486/early-pubertal-timing-and-adult-adjustment-outcomes-persistence-attenuation-or-accentuation
#11
Jennifer M Senia, M Brent Donnellan, Tricia K Neppl
Early pubertal timing is associated with internalizing and externalizing problems during adolescence. However, few studies explicitly test whether early puberty is especially problematic for those with pre-existing problems (i.e., accentuation) and little is known about whether the negative correlates of early pubertal timing persist past young adulthood. We address these questions using longitudinal data from up to 451 participants in the Iowa Youth and Families project (e.g., Ge, Conger, & Elder, 1996, 2001)...
March 16, 2018: Journal of Adolescence
https://www.readbyqxmd.com/read/29547741/unraveling-age-puberty-and-testosterone-effects-on-subcortical-brain-development-across-adolescence
#12
Lara M Wierenga, Marieke G N Bos, Elisabeth Schreuders, Ferdi Vd Kamp, Jiska S Peper, Christian K Tamnes, Eveline A Crone
The onset of adolescence in humans is marked by hormonal changes that give rise to secondary sexual characteristics, noted as puberty. It has, however, proven challenging to unravel to what extent pubertal changes may have organizing effects on the brain beyond chronological age, as reported in animal studies. The present longitudinal study aimed to characterize the unique effects of age and puberty on subcortical brain volumes and included three waves of data collection at two-year intervals and 680 T1-weighted MRI scans of 271 participants (54% females) aged between 8 and 29 years old...
March 8, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29547111/-sex-bias-in-allergic-asthma-androgens-and-group-2-innate-lymphoid-cells
#13
Sophie Laffont, Eve Blanquart, Jean-Charles Guéry
Allergic asthma is a chronic pulmonary inflammatory disease initiated by exposure to normally harmless allergens and marked by bronchial hyperreactivity. It affects more than 300 million people worldwide. Asthma often starts in childhood. Epidemiological studies show that there are sexual disparities in the prevalence and severity of asthma. Before the age of 10, the disease is more common in boys. This tendency reverses at puberty suggesting a regulating role of the sex hormones. In this synthesis, we summarize current knowledge on the role of sex hormones in allergic inflammation, with a particular focus on the impact of androgens on the development and function of recently introduced group 2 innate lymphoid cell subsets (ILC2) as critical actors in the initiation of allergic responses...
March 2018: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/29538744/in-vitro-formation-of-the-blood-testis-barrier-during-long-term-organotypic-culture-of-human-prepubertal-tissue-comparison-with-a-large-cohort-of-pre-peripubertal-boys
#14
F de Michele, J Poels, M G Giudice, F De Smedt, J Ambroise, M Vermeulen, D Gruson, C Wyns
STUDY QUESTION: How does the formation of the blood-testis barrier (BTB), as reflected by the expression of connexin 43 and claudin 11 proteins during the pubertal transition period, take place in vitro compared to samples from a large cohort of pre/peripubertal boys? SUMMARY ANSWER: The BTB connexin 43 and claudin 11 expression patterns appeared to be partially achieved in organotypic culture when compared to that in samples from 71 pre/peripubertal patients. WHAT IS KNOWN ALREADY: Although alterations in the protein expression patterns of the BTB, whose main components are connexin 43 and claudin 11, are known to be associated with impaired spermatogenesis in mice and adult men, there is a lack of knowledge on its formation in pre-peripubertal human tissue both in vitro and in vivo...
March 12, 2018: Molecular Human Reproduction
https://www.readbyqxmd.com/read/29538680/spontaneous-fertility-in-a-male-patient-with-testotoxicosis-despite-suppression-of-fsh-levels
#15
M Cunha-Silva, V N Brito, D B Macedo, D S Bessa, C O Ramos, L G Lima, P S Barroso, I J P Arnhold, D L Segaloff, B B Mendonca, A C Latronico
Testotoxicosis is a rare cause of peripheral precocious puberty in boys caused by constitutively activating mutations of the LHCG receptor. Affected males usually have normal gonadotropin profiles and fertility in their adult life. Here, we described the long-term follow-up of a 24-year-old young man with severe testotoxicosis due to a de novo activating mutation in the third transmembrane helix of the LHCGR (p.Leu457Arg). This patient was treated with different medications, including medroxyprogesterone acetate, ketoconazole, cyproterone acetate and aromatase inhibitor from age 2...
March 12, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29532534/bmi-change-during-puberty-and-the-risk-of-heart-failure
#16
J M Kindblom, M Bygdell, A Sondén, J Célind, A Rosengren, C Ohlsson
AIM: Hospitalization for heart failure amongst younger men has increased. The reason for this is unknown but it coincides with the obesity epidemic. The aim of this study was to evaluate the association between childhood BMI (Body Mass Index) and BMI change during puberty for risk of adult heart failure in men. METHODS: Using the BMI Epidemiology Study (BEST), a population-based study in Gothenburg, Sweden, we collected information on childhood BMI at age 8 years and BMI change during puberty (BMI at age 20 - BMI at 8) for men born 1945-1961, followed until December 2013 (n = 37 670)...
March 12, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29519117/assessment-of-nutritional-behaviours-of-children-aged-7-12-attending-to-primary-schools-in-biala-podlaska-poland
#17
Anna Galczak-Kondraciuk, Paweł Stempel, Jan Czeczelewski
Background: Children and youth constitute a group that is particularly prone to the effects of improper diet. In the puberty period, numerous significant lifestyle choices are made, for instance regarding particular nutritional behaviours which may be repeated later in life and may determine the state of health. Objective: The aim of the study was to assess nutritional behaviours of children aged 7-12 attending to primary schools in Biala Podlaska county (Eastern Region of Poland)...
2018: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/29500075/-immunosuppressive-therapy-and-fertility-preservation-indications-and-methods
#18
C Choux, M Cavalieri, J Barberet, M Samson, B Bonnotte, P Fauque, P Sagot
Fertility preservation is routinely performed in cancerology but less systematically used in the field of immune diseases, even though the use of gonadotoxic treatments in young patients may be required and even though the disease itself can alter fertility. This review aimed to clarify the indications and methods of fertility preservation in this context. Cyclophosphamide is the only immunosuppressive drug requiring fertility preservation in women. In men, fertility preservation should be proposed before treatment with cyclophosphamide, methotrexate, mycophenolate mofetil or mTOR inhibitors...
February 27, 2018: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29487555/the-interplay-between-gaze-following-emotion-recognition-and-empathy-across-adolescence-a-pubertal-dip-in-performance
#19
Rianne van Rooijen, Caroline M M Junge, Chantal Kemner
During puberty a dip in face recognition is often observed, possibly caused by heightened levels of gonadal hormones which in turn affects the re-organization of relevant cortical circuitry. In the current study we investigated whether a pubertal dip could be observed in three other abilities related to social information processing: gaze following, emotion recognition from the eyes, and empathizing abilities. Across these abilities we further explored whether these measurements revealed sex differences as another way to understand how gonadal hormones affect processing of social information...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29481988/the-association-between-digit-ratio-2d-4d-and-the-first-spermatorrhea-among-chinese-boys
#20
Ting Li, Lu Wu, Yujie Wang, Rongying Yao, Yanqiu Meng, Yifei Zhang, Zhiqiang Li, Yanni Zhou, Hui Han, Lianguo Fu
BACKGROUND: The second-to-fourth digit ratio (2D:4D) is a marker of prenatal hormone exposure, which is negatively correlated with prenatal androgen and positively correlated with prenatal estrogen. The study was to analyze the association between 2D:4D and the first spermatorrhea to indirectly show the possible role of prenatal hormone during puberty development among boys. METHOD: The total of 367 boys aged 8-15 years were enrolled by using the stratified cluster sampling method...
February 23, 2018: Early Human Development
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