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https://www.readbyqxmd.com/read/29931143/oxandrolone-treatment-results-in-an-increased-risk-of-gonadarche-in-prepubertal-boys-with-klinefelter-syndrome
#1
Shanlee M Davis, Najiba Lahlou, Matthew Cox-Martin, Karen Kowal, Philip S Zeitler, Judith L Ross
Context: Klinefelter syndrome (KS) is a common genetic condition in which males have an extra X chromosome. KS is associated with testosterone deficiency, neurodevelopmental delays, and cardiometabolic disorders. There has been recent interest in prepubertal androgen treatment, however the effects on puberty and gonadal function are unknown. Objective: To compare onset of puberty and testicular function in pre-pubertal boys treated with two years of oxandrolone versus placebo...
June 20, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29917083/sex-differences-in-reproductive-hormones-during-mini-puberty-in-infants-with-normal-and-disordered-sex-development
#2
T H Johannsen, K M Main, M L Ljubicic, T K Jensen, H R Andersen, M S Andersen, J H Petersen, A-M Andersson, A Juul
CONTEXT: The early activation of the hypothalamic-pituitary-gonadal axis during infancy can be used in the evaluation of infants suspected of disorders of sex development (DSD). However, few data exists on sex-specific reference ranges for these hormones during early life. OBJECTIVE: To evaluate sex-differences in reproductive hormone concentrations in serum from healthy infants in order to define sex-specific cut-off values and to apply these in infants with DSD...
June 15, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29911041/height-velocity-in-apparently-healthy-north-indian-school-children
#3
Aashima Dabas, Rajesh Khadgawat, Monita Gahlot, Vineet Surana, Neena Mehan, Rekha Ramot, Aparna Pareek, V Sreenivas, Raman Kumar Marwaha
Objective: Linear growth is best estimated by serial anthropometric data or height velocity (HV). In the absence of recent data on growth velocity, we undertook to establish normative data in apparently healthy North Indian children. Materials and Methods: Prospective longitudinal study in a representative sample of 7710 apparently healthy children, aged 3-17 years from different regions of Delhi. Height was measured at baseline and at 12 months while pubertal examination was performed at baseline in a subset of children...
March 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29894754/high-sensitivity-quantification-of-serum-androstenedione-testosterone-dihydrotestosterone-estrone-and-estradiol-by-gas-chromatography-tandem-mass-spectrometry-with-sex-and-puberty-specific-reference-intervals
#4
Carina Ankarberg-Lindgren, Jovanna Dahlgren, Mats X Andersson
BACKGROUND: Androgen and estrogen determinations serve as important diagnostic markers in a variety of clinical conditions. However, one challenge is to enhance assay sensitivity for determination in the lowest range, such as in prepubertal children. We here present a recently developed gas chromatography-tandem mass spectrometry (GC-MS/MS) method for determination of androstenedione (A4 ), dihydrotestosterone (DHT), testosterone (T), estrone (E1 ), and estradiol (E2 ) in children, which we have compared with the sensitive radioimmunoassays; E2 extraction-RIA and T-RIA...
June 9, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29892044/polygenic-differential-susceptibility-to-cumulative-stress-exposure-and-childhood-obesity
#5
Ying Sun, Jiao Fang, Yuhui Wan, Jingjing Hu, Yuanyuan Xu, Fangbiao Tao
OBJECTIVE: To examine whether polygenic susceptibility for body mass index (BMI) interacts with cumulative stress exposure, potentially exacerbating and buffering the effects of chronic stress, to predict obesity during childhood. METHODS: Data were analyzed from an established prospective puberty cohort in Anhui province, China. A total of 1000 children (421 boys and 579 girls, mean (standard deviation) age 8.97 (0.86) years) who had complete DNA genotyping, hair cortisol concentration and BMI were eligible for the study...
June 11, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29882476/processing-gender-lived-experiences-of-reproducing-and-transforming-gender-norms-over-the-life-course-of-young-people-in-northern-uganda
#6
Rebecka Lundgren, Sarah Burgess, Heather Chantelois, Susan Oregede, Brad Kerner, Anna E Kågesten
The years between 10-19 represent a critical stage of human development during which boys and girls learn and embody socially constructed gender norms, with long-term implications for their sexual and reproductive health. This ethnographic cohort study sought to understand how gendered norms and practices develop during the transition from child to young adult in post-conflict northern Uganda. A total of 60 girls and boys aged 10-19 were selected using purposive sampling for in-depth interviews over a three-year period; 47 individuals completed all four interviews...
June 8, 2018: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/29860506/ghrelin-and-peptide-yy-change-during-puberty-relationships-with-adolescent-growth-development-and-obesity
#7
Hoi Lun Cheng, Amanda Sainsbury, Frances Garden, Myuran Sritharan, Karen Paxton, Georgina Luscombe, Catherine Hawke, Katharine Steinbeck
Context: Pubertal adolescents show strong appetites. How this is mediated is unclear, but ghrelin and peptide YY (PYY) play potentially important roles. Objective: To measure ghrelin and PYY change in relation to pubertal growth. Design: Three-year prospective cohort study. Setting: Australian regional community. Participants: Eighty healthy adolescents (26 girls; 54 boys) recruited at 10-13y. Main outcome measures: Fasting circulating total ghrelin, total PYY, insulin-like growth factor 1 (IGF-1), insulin, leptin (via radioimmunoassay); estradiol and testosterone (via mass spectrometry); anthropometry and body composition (via bioelectrical impedance)...
May 31, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29858631/the-associations-between-the-changes-in-serum-inflammatory-markers-and-bone-mineral-accrual-in-boys-with-overweight-and-obesity-during-pubertal-maturation-a-3-year-longitudinal-study-in-estonian-boys
#8
E Mengel, V Tillmann, L Remmel, P Kool, P Purge, E Lätt, J Jürimäe
Adipose tissue produces different inflammatory cytokines which compromise bone mineral accrual during puberty. Vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), interleukin (IL)-8, and interferon-gamma (IFN-γ) are significantly related to bone mineral accrual during pubertal maturation in boys with different BMI values. INTRODUCTION: This longitudinal study aims to identify the inflammatory markers that most strongly associate with pubertal bone mineral density (BMD) increment in boys with overweight and obesity (OWB)...
June 1, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29795206/estimating-secular-changes-in-longitudinal-growth-patterns-underlying-adult-height-with-the-qeps-model-the-grow-up-gothenburg-cohorts
#9
Anton Holmgren, Aimon Niklasson, Andreas F M Nierop, Lars Gelander, A Stefan Aronson, Agneta Sjöberg, Lauren Lissner, Kerstin Albertsson-Wikland
BACKGROUND: Over the past 150 years, humans have become taller, and puberty has begun earlier. It is unclear if these changes are continuing in Sweden, and how longitudinal growth patterns are involved. We aimed to evaluate the underlying changes in growth patterns from birth to adulthood by QEPS estimates in two Swedish cohorts born in 1974 and 1990. METHODS: Growth characteristics of the longitudinal 1974 and 1990-birth cohorts (n = 4181) were compared using the QEPS model together with adult heights...
May 23, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29779250/soy-protein-supplement-intake-for-12-months-has-no-effect-on-sexual-maturation-and-may-improve-nutritional-status-in-pre-pubertal-children
#10
Sandra M Duitama, Javier Zurita, Diana Cordoba, Paola Duran, Leopold Ilag, Wilson Mejia
AIM: To evaluate the intake of a soy protein-based supplement (SPS) and its effects on the sexual maturation and nutritional status of prepubertal children who consumed it for a year. METHODS: Healthy children (n = 51) were recruited and randomly assigned to consume the lunch fruit juice with (n = 29) or without (n = 22) addition of 45 g of a commercial soy protein-based supplement (SPS) over 12 months. Nutritional assessment including anthropometry (bodyweight, height, triceps skinfold thickness, mid-upper arm circumference), body mass index (BMI), upper arm muscle area, arm muscle circumference, upper arm area, upper arm fat area data were derived from measures using usual procedures; age and gender-specific percentiles were used as reference...
May 20, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29774495/associations-among-early-life-stress-rumination-symptoms-of-psychopathology-and-sex-in-youth-in-the-early-stages-of-puberty-a-moderated-mediation-analysis
#11
Joelle LeMoult, Kathryn L Humphreys, Lucy S King, Natalie L Colich, Alexandria N Price, Sarah J Ordaz, Ian H Gotlib
Despite the high prevalence and substantial costs of early life stress (ELS), the mechanisms through which ELS confers risk for psychopathology are poorly understood, particularly among youth who are in an earlier stage of the transition through puberty. We sought to advance our understanding of the link between ELS and psychopathology by testing whether rumination mediates the relation between ELS and symptoms of psychopathology in youth in the early stages of puberty, and whether sex moderates this mediation...
May 17, 2018: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/29760811/global-dna-methylation-changes-spanning-puberty-are-near-predicted-estrogen-responsive-genes-and-enriched-for-genes-involved-in-endocrine-and-immune-processes
#12
Emma E Thompson, Jessie Nicodemus-Johnson, Kyung Won Kim, James E Gern, Daniel J Jackson, Robert F Lemanske, Carole Ober
Background: The changes that occur during puberty have been implicated in susceptibility to a wide range of diseases later in life, many of which are characterized by sex-specific differences in prevalence. Both genetic and environmental factors have been associated with the onset or delay of puberty, and recent evidence has suggested a role for epigenetic changes in the initiation of puberty as well. Objective: To identify global DNA methylation changes that arise across the window of puberty in girls and boys...
2018: Clinical Epigenetics
https://www.readbyqxmd.com/read/29753148/sex-related-differences-in-the-associations-between-maternal-dioxin-like-compounds-and-reproductive-and-steroid-hormones-in-cord-blood-the-hokkaido-study
#13
Chihiro Miyashita, Atsuko Araki, Takahiko Mitsui, Sachiko Itoh, Houman Goudarzi, Seiko Sasaki, Jumboku Kajiwara, Tsuguhide Hori, Kazutoshi Cho, Kimihiko Moriya, Nobuo Shinohara, Katsuya Nonomura, Reiko Kishi
BACKGROUND: Prenatal exposure to dioxin-like compounds (DLCs) irreversibly affects fetal reproductive and steroid hormone synthesis. OBJECTIVE: This study aimed to assess the relationships between maternal DLCs and cord blood reproductive and steroid hormones. METHODS: Participants in this study were pregnant women who enrolled in the Sapporo Cohort of the Hokkaido Study between 2002 and 2005. We quantified 29 DLCs during the 2nd and 3rd trimesters in maternal blood...
May 9, 2018: Environment International
https://www.readbyqxmd.com/read/29750651/predictors-of-bone-maturation-growth-rate-and-adult-height-in-children-with-central-precocious-puberty-treated-with-depot-leuprolide-acetate
#14
Karen O Klein, Sanja Dragnic, Ahmed M Soliman, Peter Bacher
BACKGROUND: Children with central precocious puberty (CPP) are treated with gonadotropin-releasing hormone agonists (GnRHa) to suppress puberty. Optimizing treatment outcomes continues to be studied. The relationships between growth, rate of bone maturation (bone age/chronological age [ΔBA/ΔCA]), luteinizing hormone (LH), predicted adult stature (PAS), as well as variables influencing these outcomes, were studied in children treated with depot leuprolide (LA Depot) Methods: Subjects (64 girls, seven boys) with CPP received LA Depot every 3 months for up to 42 months...
May 11, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29730183/genes-underlying-delayed-puberty
#15
REVIEW
S R Howard
The genetic control of pubertal timing has been a field of active investigation for the last decade, but remains a fascinating and mysterious conundrum. Self-limited delayed puberty (DP), also known as constitutional delay of growth and puberty, represents the extreme end of normal pubertal timing, and is the commonest cause of DP in both boys and girls. Familial self-limited DP has a clear genetic basis. It is a highly heritable condition, which often segregates in an autosomal dominant pattern (with or without complete penetrance) in the majority of families...
May 3, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29712621/incidence-of-lower-respiratory-tract-infections-and-atopic-conditions-in-boys-and-young-male-adults-royal-college-of-general-practitioners-research-and-surveillance-centre-annual-report-2015-2016
#16
Simon de Lusignan, Ana Correa, Richard Pebody, Ivelina Yonova, Gillian Smith, Rachel Byford, Sameera Rankiri Pathirannehelage, Christopher McGee, Alex J Elliot, Mariya Hriskova, Filipa Im Ferreira, Imran Rafi, Simon Jones
BACKGROUND: The Royal College of General Practitioners Research and Surveillance Centre comprises more than 150 general practices, with a combined population of more than 1.5 million, contributing to UK and European public health surveillance and research. OBJECTIVE: The aim of this paper was to report gender differences in the presentation of infectious and respiratory conditions in children and young adults. METHODS: Disease incidence data were used to test the hypothesis that boys up to puberty present more with lower respiratory tract infection (LRTI) and asthma...
April 30, 2018: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29705181/-natural-progression-of-premature-pubarche-and-underlying-diseases
#17
María Luisa Sancho Rodríguez, Gloria Bueno Lozano, José Ignacio Labarta Aizpún, Antonio de Arriba Muñoz
INTRODUCTION: Premature pubarche (PP) is generally thought to be a benign condition, but it can also be the first sign of underlying disease. OBJECTIVE: To analyse the aetiology and the evolution of the anthropometric, analytical and metabolic risk parameters of a group of patients with PP. MATERIAL AND METHODS: A descriptive and analytical retrospective study of 92 patients affected by PP. Anthropometry, analyses, bone age and indicators of lipid metabolism were all evaluated...
April 25, 2018: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/29684126/when-does-germ-cell-loss-and-fibrosis-occur-in-patients-with-klinefelter-syndrome
#18
D Van Saen, V Vloeberghs, I Gies, I Mateizel, K Sermon, Jean De Schepper, H Tournaye, E Goossens
STUDY QUESTION: When does germ cell loss and fibrosis occur in patients with Klinefelter syndrome (KS)? SUMMARY ANSWER: In KS, germ cell loss is not observed in testicular tissue from fetuses in the second semester of pregnancy but present at a prepubertal age when the testicular architecture is still normal, while fibrosis is highly present at an adolescent age. WHAT IS KNOWN ALREADY: Most KS patients are azoospermic at adult age because of a massive germ cell loss...
June 1, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29682070/capsuloganglionic-germinoma-a-rare-site-for-uncommon-childhood-tumor
#19
Kuntal Kanti Das, Jeena Joseph, Amit Kumar Singh, Pradeep Sharma, Jayesh Sardhara, Kamlesh Singh Bhaisora, Anant Mehrotra, Arun Kumar Srivastava, Sushila Jaiswal, Rabi Narayan Sahu, Awadhesh Kumar Jaiswal, Sanjay Behari
Germ cell tumors (GCTs) are rare intracranial tumors with a strong predilection for children. Commonly, these tumors arise either in the suprasellar or the pineal region. The basal ganglia-thalamus complex represents a rare site of nonmidline intracranial GCTs. Such basal ganglionic GCTs have been reported to produce certain interesting clinico-radiological features, the knowledge of which may provide important diagnostic clues preoperatively. We present the case of a 9.5-year-old boy who presented with right hemiparesis and precocious puberty...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29680294/klinefelter-syndrome-the-effects-of-early-androgen-therapy-on-competence-and-behavioral-phenotype
#20
REVIEW
Ryan Flannigan, Premal Patel, Darius A Paduch
INTRODUCTION: Klinefelter syndrome (KS) is the result of sex chromosome aneuploidy most often characterized as 47,XXY. The typical features of KS include tall stature, gynecomastia, small firm testicles, hypergonadotropic hypogonadism, and infertility. However, abnormalities in neurodevelopment, cognition, and social and behavioral functioning also can be present. The abnormalities in neurodevelopment are believed to be due in part to androgen deficiency during early development and puberty...
April 18, 2018: Sexual Medicine Reviews
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