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https://www.readbyqxmd.com/read/28424059/insight-into-human-pubertal-growth-by-applying-the-qeps-growth-model
#1
Anton Holmgren, Aimon Niklasson, Lars Gelander, A Stefan Aronson, Andreas F M Nierop, Kerstin Albertsson-Wikland
BACKGROUND: Computerized mathematical models describing absolute and relative individual growth during puberty in both cm and standard deviation (SD)-scores are lacking. The present study aimed to fill this gap, by applying the QEPS-model that delineates mathematically the specific pubertal functions of the total growth curve. METHODS: Study population used was the individual growth curves of the longitudinally followed cohort GrowUp1974 Gothenburg (n = 2280)...
April 19, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28400459/investigating-the-relationship-between-precocious-puberty-and-obesity-a-cross-sectional-study-in-shanghai-china
#2
Chang Chen, Yunting Zhang, Wanqi Sun, Yao Chen, Yanrui Jiang, Yuanjin Song, Qinmin Lin, Lixia Zhu, Qi Zhu, Xiumin Wang, Shijian Liu, Fan Jiang
OBJECTIVES: Obesity is reported to be closely relevant to early sexual development but the relationship between sexual precocity and obesity or central obesity is still inconsistent, especially in boys. We aimed to investigate the relationship between precocious puberty and obesity as well as central obesity. DESIGN: A large population-based cross-sectional study using multistage, stratified cluster random sampling. SETTING: Data from the Shanghai Children's Health, Education and Lifestyle Evaluation (SCHEDULE) study in June 2014...
April 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28397355/sex-differences-in-athletic-performance-emerge-coinciding-with-the-onset-of-male-puberty
#3
David J Handelsman
BACKGROUND: Male performance in athletic events begins to exceed that of age-matched females during early adolescence but the timing of this divergence relative to the onset of male puberty and the rise of circulating testosterone remains poorly defined. DESIGN: This study is a secondary quantitative analysis of four published sources which aimed to define the timing of the gender divergence in athletic performance and relating it to the rise in circulating testosterone due to male puberty...
April 11, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28395463/-the-combined-effect-of-spermarche-menarche-and-obesity-on-elevated-blood-pressure-among-chinese-students
#4
Y Song, J Ma, B Zhang, P J Hu
Objective: To investigate the association between the combined effect of spermarche/menarche and obesity with elevated blood pressure among Chinese students. Methods: A total of 106 009 primary and secondary school students (55 614 boys and 50 395 girls) were selected from " 2014 National Physical Fitness and Health Surveillance" (including 31 provinces, with the exception of Hong Kong, Macao, and Taiwan) with full record of height, weight, blood pressure, puberty development data of spermarche/menarche. The level of blood pressure, as well as the prevalence of high blood pressure(HBP), were compared between different subgroups (pre-spermarche/menarche and non-obesity group, pre-spermarche/menarche and obesity group, pro-spermarche/menarche and non-obesity group, pro-spermarche/menarche and obesity group), and mulilevel logistic model was used to investigate the relationship between puberty development, obesity and blood pressure...
April 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28378787/from-lark-to-owl-developmental-changes-in-morningness-eveningness-from-new-borns-to-early-adulthood
#5
Christoph Randler, Corina Faßl, Nadine Kalb
Morningness-eveningness or chronotype changes significantly throughout the life span. This has been reported for the transition during adolescence in some studies, and to a lesser extent in early adulthood. Primary and pre-school children have been under investigation in fewer studies. This is the first comprehensive study covering the age range from very young children until early adulthood (0-30 years) based on the same measurement instrument. Here, we show that the turn towards eveningness starts at an early age in German children...
April 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28374175/extensive-bmi-gain-in-puberty-is-associated-with-lower-increments-in-bone-mineral-density-in-estonian-boys-with-overweight-and-obesity-a-3-year-longitudinal-study
#6
Eva Mengel, Vallo Tillmann, Liina Remmel, Pille Kool, Priit Purge, Evelin Lätt, Jaak Jürimäe
The aim of this 3-year prospective study was to examine changes in bone mineral characteristics during pubertal maturation in boys with different BMI values at the beginning of puberty and with different BMI increments during puberty. 26 boys with overweight and obesity (OWB) and 29 normal weight boys (NWB) were studied yearly for 3 years from the age of 11 years to measure the changes in different bone mineral characteristics. The OWB group was further divided into two subgroups according to extensive or non-extensive BMI increment during 3-year period...
April 3, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28362191/increase-in-depression-diagnoses-and-prescribed-antidepressants-among-young-girls-a-national-cohort-study-2000-2013
#7
Charlotte Wessel Skovlund, Lars Vedel Kessing, Lina Steinrud Mørch, Øjvind Lidegaard
AIMS: To analyse trends in depression diagnoses and antidepressant use according to age and gender. METHODS: Nationwide cohort study including all women and men of 10-49 years living in Denmark during 2000-2013. The Psychiatric Registry and Prescription Registry provided data on depression diagnoses and antidepressant medication, respectively. Incidence rates as well as 1-year prevalence rates were calculated. RESULTS: The incidence and 1-year prevalence rates of depression diagnoses increased during 2000-2013...
March 31, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/28359061/intrafamilial-phenotypic-variability-and-consequences-of-non-compliance-with-treatment-in-congenital-adrenal-hyperplasia-and-congenital-hypothyroidism-within-a-single-family%C3%A2
#8
Nicola Improda, Caroline Ponmani, Nadia Schoenmakers, Senthil Senniappan, Abigail Atterbury, Angela Barnicoat, Krishna Chatterjee, Mehul T Dattani
BACKGROUND: Coexistence of congenital adrenal hyperplasia (CAH) and congenital hypothyroidism (CH) due to TG mutation in the same non-consanguineous family is rare. CASE SERIES: We report 4 siblings born to unrelated parents, the father being an asymptomatic carrier of homozygous p.V281L and heterozygous p.I172N CYP21A2 mutations. Sibling 1 had salt-wasting CAH (CYP21A2 genotype Intron 2 splice/p.I172N and p.V281L). She also had CH (TG genotype p.R296/ p.T1416Rfs*30) and learning difficulties...
March 30, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28339861/constitutive-luteinizing-hormone-receptor-signaling-causes-sexual-dysfunction-and-leydig-cell-adenomas-in-male-mice1
#9
Lan Hai, Deepak S Hiremath, Marilène Paquet, Prema Narayan
The luteinizing hormone receptor (LHCGR) is necessary for fertility and genetic mutations cause defects in reproductive development and function. Activating mutations in LHCGR cause familial male limited precocious puberty (FMPP). We have previously characterized a mouse model (KiLHRD582G) for FMPP that exhibits the same phenotype of precocious puberty, Leydig cell hyperplasia and elevated testosterone as boys with the disorder. We observed that KiLHRD582G male mice became infertile by 6 months of age although sperm count and motility were normal...
February 17, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28334719/meta-analysis-of-paediatric-patients-with-central-precocious-puberty-treated-with-intramuscular-triptorelin-11-25-mg-3-month-prolonged-release-formulation%C3%A2
#10
Adélaïde Durand, Maithé Tauber, Bharat Patel, Pascale Dutailly
BACKGROUND/AIMS: A meta-analysis was undertaken to assess the effect of triptorelin 11.25 mg 3-month prolonged-release formulation in central precocious puberty (CPP). METHODS: All available clinical studies with triptorelin 11.25 mg were included. The primary outcome was the proportion of children with suppressed luteinising hormone (LH) response (peak LH ≤3 IU/L) to the gonadotrophin-releasing hormone (GnRH) test 3 months after triptorelin 11.25 mg injection...
March 23, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28332107/mechanisms-driving-gender-differences-in-asthma
#11
REVIEW
Hubaida Fuseini, Dawn C Newcomb
PURPOSE OF REVIEW: Many phenotypes of asthma exist, ranging from mild asthma with onset during childhood to severe asthma with later onset, making asthma a broad disease with different pathologies. A gender disparity exists in asthma prevalence. As adults, women have an increased asthma prevalence compared to men. Further, women are more likely to have severe asthma and a later onset of asthma compared to men. Here, we review clinical and animal studies that have defined the role of sex hormones in airway inflammation, smooth muscle contraction, mucus production, and airway mechanics associated with asthma pathogenesis...
March 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28326606/physical-activity-sedentary-time-and-bone-strength-from-childhood-to-early-adulthood-a-mixed-longitudinal-hr-pqct-study
#12
Leigh Gabel, Heather M Macdonald, Lindsay Nettlefold, Heather A McKay
Bone strength is influenced by bone geometry, density, and bone microarchitecture, which adapt to increased mechanical loads during growth. Physical activity (PA) is essential for optimal bone strength accrual; however, less is known about how sedentary time influences bone strength and its determinants. Thus, our aim was to investigate the prospective associations between PA, sedentary time, and bone strength and its determinants during adolescence. We used HR-pQCT at distal tibia (8% site) and radius (7% site) in 173 girls and 136 boys (aged 9 to 20 years at baseline)...
March 22, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28323923/genetic-variation-of-follicle-stimulating-hormone-action-is-associated-with-age-at-testicular-growth-in-boys
#13
Alexander S Busch, Casper P Hagen, Katharina M Main, Anita Pereira, Camila Corvalan, Kristian Almstrup, Veronica Mericq, Anders Juul
Context: Although genetic factors play a pivotal role in male pubertal timing, genome-wide association studies have identified only a small number of loci. Genetic variation of FSH action affects adult reproductive parameters and female pubertal timing. Objective: To investigate whether genetic variation affecting FSH action is associated with onset of puberty in boys. Design: Cross-sectional and longitudinal study of two cohorts of healthy boys...
February 27, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28318781/spinal-fusion-in-a-patient-with-fukuyama-congenital-muscular-dystrophy
#14
Kaori Hino, Mitsumasa Fukuda, Tadao Morino, Tadanori Ogata, Masanori Ito, Eiichi Ishii
Many studies have evaluated surgical treatments for spinal deformities in patients with neuromuscular disease. However, few reports have described patients with Fukuyama congenital muscular dystrophy (FCMD). A 13-year-old boy with FCMD was unable to sit for long periods or sleep in the supine position because of progressive scoliosis. His Cobb angle worsened from 27° to 41° in 5months. He underwent standard posterior spinal fusion and pedicle-screw-alone fixation from T5 to S1. Postoperatively, his Cobb angle improved from 41° to 25° without exacerbation for 2years...
March 16, 2017: Brain & Development
https://www.readbyqxmd.com/read/28299573/mkrn3-levels-in-girls-with-central-precocious-puberty-and-correlation-with-sexual-hormone-levels-a-pilot-study
#15
Anna Grandone, Grazia Cirillo, Marcella Sasso, Carlo Capristo, Gianluca Tornese, Pierluigi Marzuillo, Caterina Luongo, Giuseppina Rosaria Umano, Adalgisa Festa, Ruggero Coppola, Emanuele Miraglia Del Giudice, Laura Perrone
PURPOSE: Recently, mutations of makorin RING-finger protein 3 (MKRN3) have been described in familial central precocious puberty. Serum levels of this protein decline before the pubertal onset in healthy girls and boys. The aim of the study is to investigate MKRN3 circulating levels in patients with central precocious puberty. METHODS: We performed an observational cross-sectional study. We enrolled 17 patients with central precocious puberty aged 7 years (range: 2-8 years) and breast development onset <8 years; 17 prepubertal control age-matched patients aged 6...
March 15, 2017: Endocrine
https://www.readbyqxmd.com/read/28287641/fertility-preservation-in-an-adolescent-boy-inducing-puberty-and-spermatogenesis-prior-to-elective-non-urgent-bone-marrow-transplantation
#16
C Ho, M Zacharin
No abstract text is available yet for this article.
March 13, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28285608/sex-differences-in-adolescents-glycaemic-and-insulinaemic-responses-to-high-and-low-glycaemic-index-breakfasts-a-randomised-control-trial
#17
Simon B Cooper, Karah J Dring, John G Morris, Ben E W Cousins, Maria L Nute, Mary E Nevill
During puberty young people undergo significant hormonal changes which affect metabolism and, subsequently, health. Evidence suggests there is a period of transient pubertal insulin resistance, with this effect greater in girls than boys. However, the response to everyday high and low glycaemic index (GI) meals remains unknown. Following ethical approval, forty adolescents consumed a high GI or low GI breakfast, in a randomised cross-over design. Capillary blood samples were taken during a 2-h postprandial period, examining the glycaemic and insulinaemic responses...
March 13, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28261833/diagnostic-utility-of-testosterone-priming-prior-to-dynamic-tests-to-differentiate-constitutional-delay-in-puberty-from-isolated-hypogonadotropic-hypogonadism
#18
Suja P Sukumar, Anil Bhansali, Naresh Sachdeva, Chirag Kamal Ahuja, Ujjwal Gorsi, Kush Dev Singh Jarial, Rama Walia
CONTEXT: Differentiation between constitutional delay in puberty (CDP) and isolated hypogonadotropic hypogonadism (IHH) during adolescence is a great clinical challenge, and the available diagnostic tests are of limited value. OBJECTIVE: To study the effect of withdrawal of short-term, low-dose testosterone therapy (testosterone priming) on the discriminatory power of dynamic tests for hypothalamo-pituitary-testicular axis to differentiate CDP from IHH. DESIGN: A prospective study (n = 30) consisting of 20 boys with delayed puberty (group A) and 10 patients with IHH (group B)...
March 5, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28257149/pubertal-testis-volume-age-at-pubertal-onset-and-adolescent-blood-pressure-evidence-from-hong-kong-s-children-of-1997-birth-cohort
#19
Man Ki Kwok, Gabriel M Leung, C Mary Schooling
OBJECTIVES: A warning from Health Canada suggests that testosterone increases blood pressure (BP). No evidence from large randomized controlled trials is available, and observational studies are confounded by ill-health lowering serum testosterone. To address the evidence gap, we assessed the association of pubertal testicular volume, as a reflection of testosterone production, with BP. METHODS: We examined whether testicular volume was associated with sex-, age-, and height-standardized BP z-score at ∼13 years in a population-representative Chinese birth cohort (n = 5195, 63% follow-up)...
March 3, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/28239958/differential-sex-effects-of-systolic-blood-pressure-and-low-density-lipoprotein-cholesterol-on-type-2-diabetes-life-course-data-from-the-bogalusa-heart-study
#20
Benjamin D Pollock, Wei Chen, Emily W Harville, Tian Shu, Vivian Fonseca, Franck Mauvais-Jarvis, Tanika N Kelly, Lydia A Bazzano
BACKGROUND: There may be sex-specific cardiometabolic mechanisms early in life that affect the development of type 2 diabetes mellitus (T2DM) through mid-adulthood. However, few studies have examined whether early life course interactions between cardiometabolic risk factors and sex are associated with incident T2DM. METHODS: This study followed 7725 children (3834 [49.6%] females, 3891 [50.4%] males) from the Bogalusa Heart Study through mid-adulthood to examine whether low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), body mass index (BMI), or systolic blood pressure (SBP) differentially affect the risk of T2DM for females versus males...
February 27, 2017: Journal of Diabetes
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