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https://www.readbyqxmd.com/read/28728112/reductive-defluorination-of-perfluorooctanoic-acid-by-titanium-iii-citrate-with-vitamin-b12-and-copper-nanoparticles
#1
Yu-Chi Lee, Yi-Pei Chen, Meng-Jia Chen, Jeff Kuo, Shang-Lien Lo
Perfluorooctanoic acid (PFOA) is widespread in the environment, which causes serious health and safety concerns. A mechanistic study on reductive defluorination of PFOA by titanium(III) citrate in the presence of catalysts was conducted. Vitamin B12 was used to catalyze reduction reactions by shuttling electrons from a reducing agent (electron donor) to PFOA to produce a Co-carbon bond intermediates. In the presence of copper nanoparticles, a precursor complex, B12-C7F14COOH, adsorbed on the metal surface, followed by a hydrogenolytic reaction to form less-fluorinated products...
June 29, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28727446/reductive-outer-sphere-single-electron-transfer-is-an-exception-rather-than-the-rule-in-natural-and-engineered-chlorinated-ethene-dehalogenation
#2
Benjamin Heckel, Stefan Cretnik, Sarah Kliegman, Orfan Shouakar-Stash, Kristopher McNeill, Martin Elsner
Chlorinated ethenes (CEs) such as perchloroethylene, trichloroethylene and dichloroethylene are notorious groundwater contaminants. Although reductive dehalogenation is key to their environmental and engineered degradation, underlying reaction mechanisms remain elusive. Outer-sphere reductive single electron transfer (OS-SET) has been proposed for such different processes as Vitamin B12-dependent biodegradation and zero-valent metal-mediated dehalogenation. Compound-specific isotope effect (13C/12C, 37Cl/35Cl) analysis offers a new opportunity to test these hypotheses...
July 20, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28726793/correction-vitamin-b12-deficiency
#3
Ralph Green, Lindsay H Allen, Anne-Lise Bjørke-Monsen, Alex Brito, Jean-Louis Guéant, Joshua W Miller, Anne M Molloy, Ebba Nexo, Sally Stabler, Ban-Hock Toh, Per Magne Ueland, Chittaranjan Yajnik
This corrects the article DOI: 10.1038/nrdp.2017.40.
July 20, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28726436/is-it-intestinal-tuberculosis-again-case-report
#4
Kristián Brat, Zdeněk Merta, Ivan Čundrle
This case report focuses on an immigrant admitted to the Department of Respiratory Diseases, University Hospital Brno due to suspicion of relapsing intestinal tuberculosis. The patient presented with fever, night sweat, weight loss, diarrhea, and a history of several tuberculosis attacks in the last few years. None of the examinations confirmed the presence of active tuberculosis but raised suspicion of hematological malignancy. Pancytopenia was present in the peripheral blood. However, bone marrow examination and flowcytometry excluded the presence of a hematological malignancy...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/28726051/serum-methylmalonic-acid-correlates-with-neuropathic-pain-in-idiopathic-parkinson-s-disease
#5
Jin-Sung Park, Donghwi Park, Pan-Woo Ko, Kyunghun Kang, Ho-Won Lee
Recent studies have shown a relatively higher prevalence of peripheral neuropathy in idiopathic Parkinson's disease (IPD). The hypothesis is that prolonged levodopa exposure causes vitamin B12 deficiency, which leads to peripheral neuropathy. The aim of our study was to find the relationship between vitamin B12 and its precursor methylmalonic acid (MMA) in IPD patients with neuropathic pain. We performed a cross-sectional study by enrolling consecutive 43 patients who were clinically tested positive for F-18 FP-CIT PET and 15 patients were diagnosed with peripheral neuropathy according to the Toronto clinical scoring system (TCSS)...
July 19, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28723303/folate-serum-levels-in-italian-women-entering-an-in-vitro-fertilization-program
#6
Adalisa Ponzano, Gian Mario Tiboni
Italian public health authorities recommend women of childbearing age to assume a daily dose of 0.4 mg of folic acid (FA) from at least one month before conception in order to reduce the risk of having children affected by neural tube defects (NTDs). In this study, folate, homocysteine and vitamin B12 serum levels were determined in 77 women entering an in vitro fertilization program. About 75% of patients had serum folate values compatible with the intake of the recommended dose of FA for at least three months, whereas only the 61% of them reached or exceeded the serum folate concentration regarded as the optimal concentration during the periconceptional period...
July 19, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28721209/recent-advances-in-preventing-stroke-recurrence
#7
REVIEW
J David Spence
Recent advances in secondary stroke prevention include new evidence in hypertension, nutrition, anticoagulation, antiplatelet therapy, intracranial stenosis, percutaneous closure of patent foramen ovale, and lipid-lowering therapy. Individualized therapy for hypertension based on phenotyping with plasma renin and aldosterone markedly improves blood pressure control in patients with resistant hypertension. A Mediterranean diet can reduce the risk of stroke by nearly half. The diagnosis and treatment of metabolic vitamin B12 deficiency, and B vitamins to lower homocysteine, can reduce the risk of stroke by approximately 30%...
2017: F1000Research
https://www.readbyqxmd.com/read/28718824/associations-between-red-meat-intakes-and-the-micronutrient-intake-and-status-of-uk-females-a-secondary-analysis-of-the-uk-national-diet-and-nutrition-survey
#8
Emma Derbyshire
Blanket health messages to lower red meat intakes are being communicated at present. These could have adverse implications on the micronutrient quality of women's diets. The current paper evaluates the nutritional impact of lower red meat intakes on British women's micronutrient intakes and status. A secondary analysis of the UK National Diet and Nutrition Survey was undertaken using data from years 2008/2009 to 2011/2012. This was comprised of dietary and blood analyte data from 1384 and 641 females aged 11 to 64 years...
July 18, 2017: Nutrients
https://www.readbyqxmd.com/read/28718091/nutritional-and-micronutrient-care-of-bariatric-surgery-patients-current-evidence-update
#9
REVIEW
Michael A Via, Jeffrey I Mechanick
PURPOSE OF REVIEW: The continued success of bariatric surgery to treat obesity and obesity-associated metabolic conditions creates a need for a strong understanding of clinical nutrition both before and after these procedures. RECENT FINDINGS: Surgically induced alteration of gastrointestinal physiology can affect the nutrition of individuals, especially among those who have undergone malabsorptive procedures. While uncommon, a subset of patients may develop protein-calorie malnutrition...
July 17, 2017: Current Obesity Reports
https://www.readbyqxmd.com/read/28715540/predictors-of-hand-foot-syndrome-and-pyridoxine-for-prevention-of-capecitabine-induced-hand-foot-syndrome-a-randomized-clinical-trial
#10
Yoon-Sim Yap, Li-Lian Kwok, Nicholas Syn, Wen Yee Chay, John Whay Kuang Chia, Chee Kian Tham, Nan Soon Wong, Soo Kien Lo, Rebecca Alexandra Dent, Sili Tan, Zuan Yu Mok, King Xin Koh, Han Chong Toh, Wen Hsin Koo, Marie Loh, Raymond Chee Hui Ng, Su Pin Choo, Richie Chuan Teck Soong
Importance: Hand-foot syndrome (HFS) is a common adverse effect of capecitabine treatment. Objective: To compare the incidence and time to onset of grade 2 or greater HFS in patients receiving pyridoxine vs placebo and to identify biomarkers predictive of HFS. Design, Setting, and Participants: This single-center, randomized double-blind, placebo-controlled phase 3 trial conducted at National Cancer Centre Singapore assessed whether oral pyridoxine could prevent the onset of grade 2 or higher HFS in 210 patients scheduled to receive single-agent capecitabine chemotherapy for breast, colorectal, and other cancers...
July 13, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28711333/b12-deficiency-leading-to-marked-poikilocytosis-versus-true-schistocytosis-a-pernicious-problem
#11
James A Hall, James Mason, Julia Choi, Mark Holguin
Severe vitamin B12 deficiency is caused most commonly by autoimmune atrophic gastritis leading to loss of intrinsic factor. Vitamin B12 deficiency leading to megaloblastic anemia and demyelinating central nervous system disease is well known; however, a rare presentation of B12 deficiency described as pseudothrombotic microangiopathy is not well known. This complication presents with signs of mechanical hemolysis, elevated lactate dehydrogenase (LDH), thrombocytopenia, and a low reticulocyte count, which can be incorrectly diagnosed as thrombotic thrombocytopenic purpura and managed incorrectly...
June 20, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28710276/atp-binding-and-hydrolysis-disrupts-the-high-affinity-interaction-between-the-heme-abc-transporter-hmuuv-and-its-cognate-substrate-binding-protein
#12
Hiba Qasem Abdullah, Michal Perach, Nurit Livnat-Levanon, Oded Lewinson
Using the energy of ATP hydrolysis ABC transporters catalyze the trans-membrane transport of molecules. In bacteria they partner with a high affinity substrate binding protein (SBP) to import essential micronutrients. ATP binding by Type-I ABC transporters (importers of amino acids, sugars, peptides, small ions) stabilizes the interaction between the transporter and the SBP, thus allowing transfer of the substrate from the latter to the former. In Type-II ABC transporters (importers of trace elements, e.g., vitamin B12, heme, iron-siderophores) the role of ATP remains debatable...
July 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28709008/iatrogenic-b12-deficient-peripheral-neuropathy-following-nitrous-oxide-administration-for-functional-tonic-leg-spasm-a-case-report
#13
Diego Kaski, Prateek Kumar, Elaine Murphy, Thomas T Warner
No abstract text is available yet for this article.
July 6, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28708674/chemotherapy-induced-peripheral-neuropathy-a-review-of-recent-findings
#14
Peggy Y Kim, Carrie E Johnson
PURPOSE OF REVIEW: Chemotherapy-induced peripheral neuropathy (CIPN) is a common, frequently chronic condition characterized by pain and decreased function. Given the growing number of cancer survivors and an increasing recognition of opioid therapy limitations, there is a need for critical analysis of the literature in directing an informed and thoughtful approach for the management of painful CIPN. RECENT FINDINGS: A PubMed search for 'chemotherapy-induced peripheral neuropathy AND pain' identifies 259 publications between 1 January 2016 and 31 March 2017...
July 13, 2017: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/28708118/low-energy-turnover-of-physically-inactive-participants-as-a-determinant-of-insufficient-mineral-and-vitamin-intake-in-nhanes
#15
Juliane Heydenreich, Katarina Melzer, Céline Flury, Bengt Kayser
Micronutrient requirements do not scale linearly with physical activity-related energy expenditure (AEE). Inactive persons may have insufficient micronutrient intake because of low energy intake (EI). We extracted data from NHANES 2003-2006 on 4015 adults (53 ± 18 years (mean ± SD), 29 ± 6 kg/m², 48% women) with valid physical activity (accelerometry) and food intake (2 × 24 h-dietary recall) measures. Total energy expenditure (TEE) was estimated by summing the basal metabolic rate (BMR, Harris-Benedict), AEE, and 10% of TEE for the thermic effect of food, to calculate the physical activity levels (PAL = TEE/BMR)...
July 14, 2017: Nutrients
https://www.readbyqxmd.com/read/28700571/open-and-closed-structures-reveal-allostery-and-pliability-in-the-hiv-1-envelope-spike
#16
Gabriel Ozorowski, Jesper Pallesen, Natalia de Val, Dmitry Lyumkis, Christopher A Cottrell, Jonathan L Torres, Jeffrey Copps, Robyn L Stanfield, Albert Cupo, Pavel Pugach, John P Moore, Ian A Wilson, Andrew B Ward
For many enveloped viruses, binding to a receptor(s) on a host cell acts as the first step in a series of events culminating in fusion with the host cell membrane and transfer of genetic material for replication. The envelope glycoprotein (Env) trimer on the surface of HIV is responsible for receptor binding and fusion. Although Env can tolerate a high degree of mutation in five variable regions (V1-V5), and also at N-linked glycosylation sites that contribute roughly half the mass of Env, the functional sites for recognition of receptor CD4 and co-receptor CXCR4/CCR5 are conserved and essential for viral fitness...
July 12, 2017: Nature
https://www.readbyqxmd.com/read/28699068/health-and-nutritional-status-of-vegetarian-candidates-for-bariatric-surgery-and-practical-recommendations
#17
Shiri Sherf-Dagan, Keren Hod, Assaf Buch, Limor Mardy-Tilbor, Ziva Regev, Tair Ben-Porat, Nasser Sakran, David Goitein, Asnat Raziel
INTRODUCTION: Data on vegetarianism and bariatric surgery (BS) are scarce. We herein describe the health and nutritional status of vegetarian patients who plan to undergo BS and propose combined recommendations for vegetarian patients who undergo BS, based on our clinical experience and current scientific literature in both nutrition fields. METHODS: Cross-sectional analysis of a prospectively maintained database of all primary laparoscopic sleeve gastrectomies (LSG) performed at a bariatric center of excellence between January 2014 and November 2016 was carried out querying patients who declared a vegetarian or vegan lifestyle before surgery...
July 11, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28699005/study-of-chlordecone-desorption-from-activated-carbons-and-subsequent-dechlorination-by-reduced-cobalamin
#18
Ronald Ranguin, Axelle Durimel, Reeka Karioua, Sarra Gaspard
Since 1972, the French departments of Guadeloupe and Martinique have intensively used organochlorinated pesticides such as chlordecone (CLD) and hexachlorocyclohexane (HCH) isomers to prevent the proliferation of banana weevil (Cosmopolite sordidus). These molecules are stable in the environment, leading to a continuous contamination of soils, water, and food chain in the banana-producing areas. In these polluted areas, water treatment plants are equipped with activated carbon (AC) filters. In order to improve treatment of CLD-contaminated waters by AC, CLD adsorption and desorption kinetic studies are carried out using different ACs produced from sugar cane bagasse as adsorbents and subsequent CLD degradation is performed using reduced vitamin B12 (VB12)...
July 11, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28698453/plasma-homocysteine-and-serum-folate-and-vitamin-b12-levels-in-mild-cognitive-impairment-and-alzheimer-s-disease-a-case-control-study
#19
Fei Ma, Tianfeng Wu, Jiangang Zhao, Lu Ji, Aili Song, Meilin Zhang, Guowei Huang
Homocysteine (Hcy) is a risk factor for brain atrophy, cognitive impairment, and dementia. Vitamin B12 and folate are cofactors necessary for the methylation of Hcy. However, there is some debate regarding the differing levels of plasma Hcy and serum folate and vitamin B12 among healthy controls, patients with mild cognitive impairment (MCI), and patients with Alzheimer's disease (AD). This study aimed to evaluate how the levels of plasma Hcy and its biological determinants, folate and vitamin B12, are related to MCI and AD in older Chinese adults...
July 8, 2017: Nutrients
https://www.readbyqxmd.com/read/28697391/nutrients-in-one-carbon-metabolism-and-urinary-arsenic-methylation-in-the-national-health-and-nutrition-examination-survey-nhanes-2003-2004
#20
Margaret Kurzius-Spencer, Vanessa da Silva, Cynthia A Thomson, Vern Hartz, Chiu-Hsieh Hsu, Jefferey L Burgess, Mary Kay O'Rourke, Robin B Harris
Exposure to inorganic arsenic (inAs), a potent toxicant, occurs primarily through ingestion of food and water. The efficiency with which it is methylated to mono and dimethyl arsenicals (MMA and DMA) affects toxicity. Folate, vitamins B12 and B6 are required for 1C metabolism, and studies have found that higher levels of these nutrients increase methylation capacity and are associated with protection against adverse health effects from inAs, especially in undernourished populations. Our aim was to determine whether 1C-related nutrients are associated with greater inAs methylation capacity in a general population sample with overall adequate nutrition and low levels of As exposure...
July 8, 2017: Science of the Total Environment
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