keyword
MENU ▼
Read by QxMD icon Read
search

Memory reconsolidation

keyword
https://www.readbyqxmd.com/read/28346453/activity-induced-histone-modifications-govern-neurexin-1-mrna-splicing-and-memory-preservation
#1
Xinlu Ding, Sanxiong Liu, Miaomiao Tian, Wenhao Zhang, Tao Zhu, Dongdong Li, Jiawei Wu, HaiTeng Deng, Yichang Jia, Wei Xie, Hong Xie, Ji-Song Guan
Epigenetic mechanisms regulate the formation, consolidation and reconsolidation of memories. However, the signaling path from neuronal activation to epigenetic modifications within the memory-related brain circuit remains unknown. We report that learning induces long-lasting histone modifications in hippocampal memory-activated neurons to regulate memory stability. Neuronal activity triggers a late-onset shift in Nrxn1 splice isoform choice at splicing site 4 by accumulating a repressive histone marker, H3K9me3, to modulate the splicing process...
March 27, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28346121/can-memories-of-traumatic-experiences-or-addiction-be-erased-or-modified-a-critical-review-of-research-on-the-disruption-of-memory-reconsolidation-and-its-applications
#2
Michael Treanor, Lily A Brown, Jesse Rissman, Michelle G Craske
Recent research suggests that the mere act of retrieving a memory can temporarily make that memory vulnerable to disruption. This process of "reconsolidation" will typically restabilize the neural representation of the memory and foster its long-term storage. However, the process of reconsolidating the memory takes time to complete, and during this limited time window, the original memory may be modified either by the presentation of new information or with pharmacological agents. Such findings have prompted rising interest in using disruption during reconsolidation as a clinical intervention for anxiety, posttraumatic stress, and substance use disorders...
March 2017: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/28302564/tackling-maladaptive-memories-through-reconsolidation-from-neural-to-clinical-science
#3
James W B Elsey, Merel Kindt
Behavioral neuroscience has greatly informed how we understand the formation, persistence, and plasticity of memory. Research has demonstrated that memory reactivation can induce a labile period, during which previously consolidated memories are sensitive to change, and in need of restabilization. This process is known as reconsolidation. Such findings have advanced not only our basic understanding of memory processes, but also hint at the prospect of harnessing these insights for the development of a new generation of treatments for disorders of emotional memory...
March 18, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28290061/accelerated-resolution-therapy-art-a-review-and-research-to-date
#4
REVIEW
Wendi Waits, Megan Marumoto, Jennifer Weaver
PURPOSE OF REVIEW: To describe and summarize published research on accelerated resolution therapy (ART), a promising and relatively new psychotherapy with the potential to offer rapid and effective resolution of a wide range of psychiatric symptoms. Unlike most evidence-based psychotherapies, ART is a predominately imaginative therapy that relies upon the rescripting of distressing events and metaphors as one of its key therapeutic elements. RECENT FINDINGS: The number of studies conducted on ART is limited, primarily consisting of one randomized, controlled trial (RCT) with 57 subjects and two large cohort studies involving 80 and 117 subjects, respectively...
March 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28286265/vicarious-extinction-learning-during-reconsolidation-neutralizes-fear-memory
#5
Armita Golkar, Cathelijn Tjaden, Merel Kindt
BACKGROUND: Previous studies have suggested that fear memories can be updated when recalled, a process referred to as reconsolidation. Given the beneficial effects of model-based safety learning (i.e. vicarious extinction) in preventing the recovery of short-term fear memory, we examined whether consolidated long-term fear memories could be updated with safety learning accomplished through vicarious extinction learning initiated within the reconsolidation time-window. We assessed this in a final sample of 19 participants that underwent a three-day within-subject fear-conditioning design, using fear-potentiated startle as our primary index of fear learning...
February 22, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28285131/retrieval-under-stress-decreases-the-long-term-expression-of-a-human-declarative-memory-via-reconsolidation
#6
Pablo Nicolás Fernández Larrosa, Alejandro Ojea, Ignacio Ojea, Victor Alejandro Molina, María Aurelia Zorrilla-Zubilete, Alejandro Delorenzi
Acute stress impairs memory retrieval of several types of memories. An increase in glucocorticoids, several minutes after stressful events, is described as essential to the impairing retrieval-effects of stressors. Moreover, memory retrieval under stress can have long-term consequences. Through what process does the reactivated memory under stress, despite the disrupting retrieval effects, modify long-term memories? The reconsolidation hypothesis proposes that a previously consolidated memory reactivated by a reminder enters a vulnerability phase (labilization) during which it is transiently sensitive to modulation, followed by a re-stabilization phase...
March 8, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28275863/post-reexposure-administration-of-d-cycloserine-facilitates-reconsolidation-of-contextual-conditioned-fear-memory-in-rats
#7
Akiyoshi Saitoh, Kie Akagi, Jun-Ichiro Oka, Mitsuhiko Yamada
The effect of D-cycloserine, a N-methyl-D-aspartate receptor partial agonist, on the reconsolidation of conditioned fear memory is not precisely understood. In this study, we clarified the effects of D-cycloserine on the reconsolidation in rats, by performing contextual fear conditioning with a mild fear-conditioning procedure and with post-reexposure administration of the drug. The D-cycloserine (15 mg/kg subcutaneously)-treated rats showed a persistent and greater fear response during the test session compared with the control group...
March 8, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28274825/brain-correlates-of-memory-reconsolidation-a-role-for-the-tpj
#8
Katharine C N S Simon, Rebecca L Gómez, Lynn Nadel, Paige E Scalf
In this paper, we investigate the process by which new experiences reactivate and potentially update old memories. Such memory reconsolidation appears dependent on the extent to which current experience deviates from what is predicted by the reactivated memory (i.e. prediction error). If prediction error is low, the reactivated memory is likely to be updated with new information. If it is high, however, a new, separate, memory is more likely to be formed. The temporal parietal junction TPJ has been shown across a broad range of content areas (attention, social cognition, decision making and episodic memory) to be sensitive to the degree to which current information violates the observer's expectations - in other words, prediction error...
March 6, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28274823/bdnf-controls-object-recognition-memory-reconsolidation
#9
Andressa Radiske, Janine I Rossato, Maria Carolina Gonzalez, Cristiano A Köhler, Lia R Bevilaqua, Martín Cammarota
Reconsolidation restabilizes memory after reactivation. Previously, we reported that the hippocampus is engaged in object recognition memory reconsolidation to allow incorporation of new information into the original engram. Here we show that BDNF is sufficient for this process, and that blockade of BDNF function in dorsal CA1 impairs updating of the reactivated recognition memory trace.
March 5, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28273291/an-integrated-neuroscience-perspective-on-formulation-and-treatment-planning-for-posttraumatic-stress-disorder-an-educational-review
#10
David A Ross, Melissa R Arbuckle, Michael J Travis, Jennifer B Dwyer, Gerrit I van Schalkwyk, Kerry J Ressler
Importance: Posttraumatic stress disorder (PTSD) is a common psychiatric illness, increasingly in the public spotlight in the United States due its prevalence in the soldiers returning from combat in Iraq and Afghanistan. This educational review presents a contemporary approach for how to incorporate a modern neuroscience perspective into an integrative case formulation. The article is organized around key neuroscience "themes" most relevant for PTSD. Within each theme, the article highlights how seemingly diverse biological, psychological, and social perspectives all intersect with our current understanding of neuroscience...
March 8, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28268256/cannabidiol-regulation-of-emotion-and-emotional-memory-processing-relevance-for-treating-anxiety-related-and-substance-abuse-disorders
#11
REVIEW
Jonathan L C Lee, Leandro J Bertoglio, Francisco S Guimarães, Carl W Stevenson
Learning to associate cues or contexts with potential threats or rewards is adaptive and enhances survival. Both aversive and appetitive memories are therefore powerful drivers of behaviour, but the inappropriate expression of conditioned responding to fear- and drug-related stimuli can develop into anxiety-related and substance abuse disorders respectively. These disorders are associated with abnormally persistent emotional memories and inadequate treatment, often leading to symptom relapse. Studies show that cannabidiol, the main non-psychotomimetic phytocannabinoid found in Cannabis sativa, reduces anxiety via 5-HT1A and (indirect) cannabinoid receptor activation in paradigms assessing innate responses to threat...
March 7, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28254465/spermidine-improves-the-persistence-of-reconsolidated-fear-memory-and-neural-differentiation-in-vitro-involvement-of-bdnf
#12
Cristiane Signor, Bruna Amanda Girardi, Arithane Lorena Wendel, Pâmella Karina Santana Frühauf, Micheli M Pillat, Henning Ulrich, Carlos F Mello, Maribel A Rubin
Putrescine, spermidine and spermine are organic cations implicated in learning, memory consolidation, reconsolidation and neurogenesis. These physiological processes are closely related, and convincing evidence indicates that neurogenesis is implicated both, in the establishment and maintenance of remote contextual fear memory. Although brain-derived neurotrophic factor (BDNF) is a key mediator involved in both neurogenesis and memory consolidation, effects of spermidine on persistence of memory after reactivation (reconsolidation) and possible involvement of BDNF have not been investigated...
February 22, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28239792/involvement-of-glycogen-synthase-kinase-3-in-the-mechanisms-of-conditioned-food-aversion-memory-reconsolidation
#13
V P Nikitin, S V Solntseva, S A Kozyrev
Experiments were performed on the snails trained in conditioned food aversion for 3 days. Injection of TDZD-8 (glycogen synthase kinase-3 inhibitor, 2 mg/kg) in combination with reminder (presentation of a conditioned food stimulus) led to memory impairment developing 3 days after inhibitor/reminder exposure and followed by spontaneous recovery in 10 days. Injections of TDZD-8 in a dose of 4 or 20 mg/kg before reminder were shown to cause amnesia that persisted for more than 10 days. Memory recovery during repeated training was observed at the earlier period than after initial training...
February 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28214541/think-twice-it-s-all-right-long-lasting-effects-of-disrupted-reconsolidation-on-brain-and-behavior-in-human-long-term-fear
#14
Johannes Björkstrand, Thomas Agren, Fredrik Åhs, Andreas Frick, Elna-Marie Larsson, Olof Hjorth, Tomas Furmark, Mats Fredrikson
Memories can be modified when recalled. Experimental fear conditioning studies support that amygdala-localized fear memories are attenuated when reconsolidation is disrupted through extinction training immediately following memory activation. Recently, using functional brain imaging in individuals with lifelong spider fears, we demonstrated that fear memory activation followed by repeated exposure to feared cues after 10min, thereby disrupting reconsolidation, attenuated activity in the amygdala during later re-exposure, and also facilitated approach behavior to feared cues...
May 1, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28202715/updating-of-aversive-memories-after-temporal-error-detection-is-differentially-modulated-by-mtor-across-development
#15
Lucille Tallot, Lorenzo Diaz-Mataix, Rosemarie E Perry, Kira Wood, Joseph E LeDoux, Anne-Marie Mouly, Regina M Sullivan, Valérie Doyère
The updating of a memory is triggered whenever it is reactivated and a mismatch from what is expected (i.e., prediction error) is detected, a process that can be unraveled through the memory's sensitivity to protein synthesis inhibitors (i.e., reconsolidation). As noted in previous studies, in Pavlovian threat/aversive conditioning in adult rats, prediction error detection and its associated protein synthesis-dependent reconsolidation can be triggered by reactivating the memory with the conditioned stimulus (CS), but without the unconditioned stimulus (US), or by presenting a CS-US pairing with a different CS-US interval than during the initial learning...
March 2017: Learning & Memory
https://www.readbyqxmd.com/read/28176459/reconsolidation-induced-rescue-of-a-remote-fear-memory-blocked-by-an-early-cortical-inhibition-involvement-of-the-anterior-cingulate-cortex-and-the-mediation-by-the-thalamic-nucleus-reuniens
#16
Rodrigo O Sierra, Lizeth K Pedraza, Querusche K Zanona, Fabiana Santana, Flávia Z Boos, Ana P Crestani, Josué Haubrich, Lucas de Oliveira Alvares, Maria Elisa Calcagnotto, Jorge A Quillfeldt
Systems consolidation is a time-dependent reorganization process involving neocortical and hippocampal networks underlying memory storage and retrieval. The involvement of the hippocampus during acquisition is well described, however we know much less about the concomitant contribution of cortical activity levels to the formation of stable remote memories. Here, after a reversible pharmacological inhibition of the anterior cingulate cortex (ACC) during the acquisition of a contextual fear conditioning, retrieval of both recent and remote memories were impaired, an effect that was reverted by a single memory reactivation session 48h after training, through a destabilization-dependent mechanism interpreted as reconsolidation, that restored the normal course of systems consolidation in order to rescue a remote memory...
February 8, 2017: Hippocampus
https://www.readbyqxmd.com/read/28174526/reconsolidation-extinction-interactions-in-fear-memory-attenuation-the-role-of-inter-trial-interval-variability
#17
Allison Auchter, Lawrence K Cormack, Yael Niv, Francisco Gonzalez-Lima, Marie H Monfils
Fear extinction typically results in the formation of a new inhibitory memory that suppresses the original conditioned response. Evidence also suggests that extinction training during a retrieval-induced labile period results in integration of the extinction memory into the original fear memory, rendering the fear memory less susceptible to reinstatement. Here we investigated the parameters by which the retrieval-extinction paradigm was most effective in memory updating. Specifically, we manipulated the inter-trial intervals (ITIs) between conditional stimulus (CS) presentations during extinction, examining how having interval lengths with different degrees of variability affected the strength of memory updating...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28171767/extinction-during-reconsolidation-eliminates-recovery-of-fear-conditioned-to-fear-irrelevant-and-fear-relevant-stimuli
#18
Alina Thompson, Ottmar V Lipp
Extant literature suggests that extinction training delivered during the memory reconsolidation period is superior to traditional extinction training in the reduction of fear recovery, as it targets the original fear memory trace. At present it is debated whether different types of fear memories are differentially sensitive to behavioral manipulations of reconsolidation. Here, we examined post-reconsolidation recovery of fear as a function of conditioned stimulus (CS) fear-relevance, using the unconditioned stimulus (US) to reactivate and destabilize conditioned fear memories...
February 2, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28169439/postretrieval-extinction-attenuates-alcohol-cue-reactivity-in-rats
#19
Roberto U Cofresí, Suzanne M Lewis, Nadia Chaudhri, Hongjoo J Lee, Marie-H Monfils, Rueben A Gonzales
BACKGROUND: Conditioned responses to alcohol-associated cues can hinder recovery from alcohol use disorder (AUD). Cue exposure (extinction) therapy (CET) can reduce reactivity to alcohol cues, but its efficacy is limited by phenomena such as spontaneous recovery and reinstatement that can cause a return of conditioned responding after extinction. Using a preclinical model of alcohol cue reactivity in rats, we evaluated whether the efficacy of alcohol CET could be improved by conducting CET during the memory reconsolidation window after retrieval of cue-alcohol associations...
March 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28169286/garcinol-blocks-the-reconsolidation-of-multiple-cocaine-paired-cues-after-a-single-cocaine-reactivation-session
#20
Amber B Dunbar, Jane R Taylor
Manipulations of memory reconsolidation can interfere with the ability of a drug-paired cue to drive drug-seeking behavior. However, the typical reconsolidation paradigm that reactivates the memory through the presentation of the cue (conditioned stimulus; CS) only interferes with the memory of the reactivated CS while leaving other drug-paired CSs intact and able to continue driving drug-seeking behavior. Here, we used a novel unconditioned-stimulus (US) reactivation paradigm to interfere with the ability of multiple cues to drive drug-seeking behavior after just one reactivation and treatment session...
February 7, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
keyword
keyword
31528
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"