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Memory reconsolidation

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https://www.readbyqxmd.com/read/28733209/intervention-strength-does-not-differentially-affect-memory-reconsolidation-of-strong-memories
#1
Kevin van Schie, Suzanne C van Veen, Yanniek R Hendriks, Marcel A van den Hout, Iris M Engelhard
Recently, it has become clear that retrieval (i.e., reactivation) of consolidated memories may return these memories into a labile state before they are restored into long-term memory ('reconsolidation'). Using behavioral manipulations, reactivated memories can be disrupted via the mechanism of novel learning. In the present study, we investigated whether changing a strong memory during reconsolidation depends on the strength of novel learning. To test this, participants (N = 144) in six groups acquired a relatively strong memory on Day 1 by viewing and recalling a series of pictures three times...
July 18, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28729064/effects-of-cannabinoid-drugs-on-aversive-and-rewarding-drug-associated-memory-extinction-and-reconsolidation
#2
REVIEW
Cristina A J Stern, Cristiane R de Carvalho, Leandro J Bertoglio, Reinaldo N Takahashi
Posttraumatic stress and drug use disorders may stem from aberrant memory formation. As the endocannabinoid (eCB) system has a pivotal role in emotional memory processing and related synaptic plasticity, here we seek to review and discuss accumulating evidence on how and where in the brain interventions targeting the eCB system would attenuate outcomes associated with traumatic events and/or drug addiction through memory extinction facilitation or memory reconsolidation disruption. Currently available data from mouse, rat, monkey and healthy human studies investigating the effects of cannabinoid drugs on the extinction and reconsolidation of aversive memories are more consistent than those related to rewarding drug-associated memories...
July 17, 2017: Neuroscience
https://www.readbyqxmd.com/read/28716956/a-comparison-of-behavioral-and-pharmacological-interventions-to-attenuate-reactivated-fear-memories
#3
Roque I Ferrer Monti, Joaquín M Alfei, Matías Mugnaini, Adrián M Bueno, Tom Beckers, Gonzalo P Urcelay, Victor A Molina
Two experiments using rats in a contextual fear memory preparation compared two approaches to reduce conditioned fear: (1) pharmacological reconsolidation blockade and (2) reactivation-plus-extinction training. In Experiment 1, we explored different combinations of reactivation-plus-extinction parameters to reduce conditioned fear and attenuate reacquisition. In Experiment 2, memory reactivation was followed by extinction training or administration of midazolam (MDZ) (vs. vehicle) to reduce conditioned fear and attenuate spontaneous recovery...
August 2017: Learning & Memory
https://www.readbyqxmd.com/read/28716952/differential-involvement-of-the-medial-prefrontal-cortex-across-variants-of-contextual-fear-conditioning
#4
Nicholas A Heroux, Patrese A Robinson-Drummer, Hollie R Sanders, Jeffrey B Rosen, Mark E Stanton
The context preexposure facilitation effect (CPFE) is a contextual fear conditioning paradigm in which learning about the context, acquiring the context-shock association, and retrieving/expressing contextual fear are temporally dissociated into three distinct phases. In contrast, learning about the context and the context-shock association happens concurrently in standard contextual fear conditioning (sCFC). By infusing the GABAA receptor agonist muscimol into medial prefrontal cortex (mPFC) in adolescent Long-Evans rats, the current set of experiments examined the functional role of the mPFC in each phase of the CPFE and sCFC...
August 2017: Learning & Memory
https://www.readbyqxmd.com/read/28710525/differential-role-of-the-anterior-and-intralaminar-lateral-thalamic-nuclei-in-systems-consolidation-and-reconsolidation
#5
Joëlle Lopez, Karine Gamache, Carmelo Milo, Karim Nader
The anterior thalamic nuclei (ATN) and the intralaminar/lateral thalamic nuclei (ILN/LT) play different roles in memory processes. The ATN are believed to be part of an extended hippocampal system, and the ILN/LT have strong connections with the medial prefrontal cortex. It was shown that the ILN/LT are involved in systems consolidation. However, whether they are necessary for memory retrieval as well remains unclear. We, therefore, used c-Fos immunohistochemistry and reversible inactivations to investigate the role of the ATN and ILN/LT in recent and remote contextual fear memory retrieval in rats...
July 14, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28705439/activation-of-nociceptin-orphanin-fq-receptors-inhibits-contextual-fear-memory-reconsolidation
#6
Khaoula Rekik, Raquel Faria Da Silva, Morgane Colom, Salvatore Pacifico, Nurulain T Zaveri, Girolamo Calo', Claire Rampon, Bernard Frances, Lionel Mouledous
Several neuropeptidergic systems act as modulators of cognitive performances. Among them, nociceptin, an opioid-like peptide also known as orphanin FQ (N/OFQ), has recently gained attention. Stimulation of its receptor, the N/OFQ opioid receptor (NOP), which is expressed in brain regions involved in emotion, memory and stress response, has inhibitory effects on the acquisition and/or consolidation of spatial and emotional memory in rodents. Recently, N/OFQ was also proposed to be linked to the pathogenesis of Post-Traumatic Stress Disorder in humans...
July 10, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28669783/gabaergic-signaling-within-the-basolateral-amygdala-complex-modulates-resistance-to-the-labilization-reconsolidation-process
#7
Pablo Javier Espejo, Pharm D Vanesa Ortiz, Irene Delia Martijena, Victor Alejandro Molina
It is well known that stress can affect mnemonic processes. In particular, stress before contextual fear conditioning induces a memory which exhibits resistance to being interfered with by Midazolam (MDZ) when applied after memory retrieval. Moreover, stress exposure strongly affects GABAergic transmission within the Basolateral Amygdala Complex (BLA), a brain structure critically involved in fear memory processing. The present study evaluated the involvement of GABAergic signaling within the BLA on the induction of resistance to memory reconsolidation interference...
June 29, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28664928/co-activation-of-metabotropic-glutamate-receptor-3-and-beta-adrenergic-receptors-modulates-cyclic-amp-long-term-potentiation-and-disrupts-memory-reconsolidation
#8
Adam G Walker, Douglas J Sheffler, Andrew S Lewis, Jonathan W Dickerson, Daniel J Foster, Rebecca K Senter, Mark S Moehle, Xiaohui Lv, Branden J Stansley, Zixiu Xiang, Jerri M Rook, Kyle A Emmitte, Craig W Lindsley, P Jeffrey Conn
Activation of β-adrenergic receptors (βARs) enhances both the induction of long-term potentiation (LTP) in hippocampal CA1 pyramidal cells and hippocampal-dependent cognitive function. Interestingly, previous studies reveal that coincident activation of group II metabotropic glutamate (mGlu) receptors with βARs in the hippocampal astrocytes induces a large increase in cyclic-AMP (cAMP) accumulation and release of adenosine. Adenosine then acts on A1 adenosine receptors at neighboring excitatory Schaffer collateral terminals, which could counteract effects of activation of neuronal βARs on excitatory transmission...
June 30, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28648649/selective-inhibition-of-amygdala-neuronal-ensembles-encoding-nicotine-associated-memories-inhibits-nicotine-preference-and-relapse
#9
Yan-Xue Xue, Ya-Yun Chen, Li-Bo Zhang, Li-Qun Zhang, Geng-Di Huang, Shi-Chao Sun, Jia-Hui Deng, Yi-Xiao Luo, Yan-Ping Bao, Ping Wu, Ying Han, Bruce T Hope, Yavin Shaham, Jie Shi, Lin Lu
BACKGROUND: Nicotine craving and relapse often occurs after reactivation of nicotine reward memories. We recently developed a memory retrieval-reconsolidation interference procedure in which reactivating nicotine reward memories by acute exposure to nicotine (the unconditioned stimulus [UCS]) and then pharmacologically interfering with memory reconsolidation decreased relapse to nicotine seeking in rats and nicotine craving in smokers. Here, we investigated underlying mechanisms. METHODS: In the first series of experiments, we trained rats for nicotine-induced conditioned place preference (CPP) or nicotine self-administration and ventricularly microinjected them with the protein synthesis inhibitor anisomycin immediately after UCS-induced memory retrieval...
May 11, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28647452/differential-roles-of-the-infralimbic-and-prelimbic-areas-of-the-prefrontal-cortex-in-reconsolidation-of-a-traumatic-memory
#10
Natali Levin, Milly Kritman, Mouna Maroun, Irit Akirav
Studies about reconsolidation of conditioned fear memories have shown that pharmacological manipulation at memory reactivation can attenuate or enhance the subsequent expression of the conditioned fear response. Here we examined the effects of a single injection of the mTOR inhibitor rapamycin (Rap) into the infralimbic (IL) and prelimbic (PL) areas [which compose the ventromedial prefrontal cortex (PFC)] on reconsolidation and extinction of a traumatic fear memory. We found opposite effects of Rap infused into the PL and IL on reconsolidation and extinction: intra-PL Rap and systemic Rap impaired reconsolidation and facilitated extinction whereas intra-IL Rap enhanced reconsolidation and impaired extinction...
June 22, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28603027/plasticity-mechanisms-of-memory-consolidation-and-reconsolidation-in-the-perirhinal-cortex
#11
REVIEW
Magdalena Miranda, Pedro Bekinschtein
In this review we explore the role of the perirhinal cortex (Prh) in memory, focusing on the cellular and molecular mechanisms that have been described to happen in this structure. The Prh is part of the medial temporal lobe, but the evidences show that it has a different function than that of the hippocampus. In particular, the Prh is known to be important for object recognition memory, although it could have a role in other types of memory. However, despite the fact that object recognition tasks are widely used, information regarding the molecular and cellular mechanisms underlying this type of memory in Prh is lacking...
June 9, 2017: Neuroscience
https://www.readbyqxmd.com/read/28549664/role-of-glucocorticoid-receptor-mediated-mechanisms-in-cocaine-memory-enhancement
#12
S J Stringfield, J A Higginbotham, R Wang, A L Berger, R J McLaughlin, R A Fuchs
The basolateral amygdala (BLA) is a critical site for the reconsolidation of labile contextual cocaine memories following retrieval-induced reactivation/destabilization. Here, we examined whether glucocorticoid receptors (GR), which are abundant in the BLA, mediate this phenomenon. Rats were trained to lever press for cocaine reinforcement in a distinct environmental context, followed by extinction training in a different context. Rats were then briefly exposed to the cocaine-paired context (to elicit memory reactivation and reconsolidation) or their home cages (no reactivation control)...
May 23, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28502663/memory-reactivation-enables-long-term-prevention-of-interference
#13
Jasmine Herszage, Nitzan Censor
The ability of the human brain to successively learn or perform two competing tasks constitutes a major challenge in daily function. Indeed, exposing the brain to two different competing memories within a short temporal offset can induce interference, resulting in deteriorated performance in at least one of the learned memories [1-4]. Although previous studies have investigated online interference and its effects on performance [5-13], whether the human brain can enable long-term prevention of future interference is unknown...
May 22, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28495311/an-update-on-memory-reconsolidation-updating
#14
REVIEW
Jonathan L C Lee, Karim Nader, Daniela Schiller
The reactivation of a stored memory in the brain can make the memory transiently labile. During the time it takes for the memory to restabilize (reconsolidate) the memory can either be reduced by an amnesic agent or enhanced by memory enhancers. The change in memory expression is related to changes in the brain correlates of long-term memory. Many have suggested that such retrieval-induced plasticity is ideally placed to enable memories to be updated with new information. This hypothesis has been tested experimentally, with a translational perspective, by attempts to update maladaptive memories to reduce their problematic impact...
May 8, 2017: Trends in Cognitive Sciences
https://www.readbyqxmd.com/read/28476650/molecular-mechanisms-controlling-protein-synthesis-in-memory-reconsolidation
#15
REVIEW
Rafael Roesler
It is currently well established that the synthesis of new proteins (mRNA translation) is required for long-lasting synaptic plasticity and memory formation. Translation in the brain is regulated primarily at the initiation stage by general as well as by gene-specific mechanisms. Stored memories can become sensitive to interference upon reactivation, through a process termed reconsolidation, which depends on protein synthesis. Here, I examine the role of translation control mechanisms, focusing particularly on the mechanistic target of rapamycin complex 1 (mTORC1), in reconsolidation...
May 2, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28469565/in-search-for-boundary-conditions-of-reconsolidation-a-failure-of-fear-memory-interference
#16
Natalie Schroyens, Tom Beckers, Merel Kindt
The presentation of a fear memory cue can result in mere memory retrieval, destabilization of the reactivated memory trace, or the formation of an extinction memory. The interaction between the degree of novelty during reactivation and previous learning conditions is thought to determine the outcome of a reactivation session. This study aimed to evaluate whether contextual novelty can prevent cue-induced destabilization and disruption of a fear memory acquired by non-asymptotic learning. To this end, fear memory was reactivated in a novel context or in the original context of learning, and fear memory reactivation was followed by the administration of propranolol, an amnestic drug...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28466871/reversal-of-cocaine-associated-synaptic-plasticity-in-prefrontal-cortex
#17
James M Otis, Devin Mueller
Addiction is characterized by abnormalities in prefrontal cortex that are thought to allow drug-associated cues to drive compulsive drug seeking and taking. Identification and reversal of these pathologic neuroadaptations is therefore critical for treatment of addiction. Previous studies using rodents reveal that drugs of abuse cause dendritic spine plasticity in prelimbic medial prefrontal cortex (PL-mPFC) pyramidal neurons, a phenomenon that correlates with the strength of drug-associated memories in vivo...
May 3, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28462472/role-of-the-agranular-insular-cortex-in-contextual-control-over-cocaine-seeking-behavior-in-rats
#18
Amy A Arguello, Rong Wang, Carey M Lyons, Jessica A Higginbotham, Matthew A Hodges, Rita A Fuchs
RATIONALE: Environmental stimulus control over drug relapse requires the retrieval of context-response-cocaine associations, maintained in long-term memory through active reconsolidation processes. Identifying the neural substrates of these phenomena is important from a drug addiction treatment perspective. OBJECTIVES: The present study evaluated whether the agranular insular cortex (AI) plays a role in drug context-induced cocaine-seeking behavior and cocaine memory reconsolidation...
May 2, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28457483/pathways-towards-the-proliferation-of-avoidance-in-anxiety-and-implications-for-treatment
#19
Inna Arnaudova, Merel Kindt, Michael Fanselow, Tom Beckers
Avoidance is a key symptom of anxiety disorders. Maladaptive avoidance impairs general functioning acutely and maintains chronic anxiety. A better understanding of the mechanisms that elicit and maintain excessive avoidance might provide opportunities to improve treatment. Here, we discuss pathways through which avoidance might get amplified in the context of anxiety disorders: 1) increased threat appraisal; 2) enhanced threat avoidance tendencies; 3) impaired regulation of avoidance; 4) habitual avoidance; and 5) attempts at increasing psychological distance...
April 19, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28456330/the-effects-of-%C3%AE-adrenergic-blockade-on-the-degrading-effects-of-eye-movements-on-negative-autobiographical-memories
#20
Marianne Littel, J Leon Kenemans, Johanna M P Baas, H N Alexander Logemann, Nellie Rijken, Malou Remijn, Rutger J Hassink, Iris M Engelhard, Marcel A van den Hout
BACKGROUND: Eye movement desensitization and reprocessing (EMDR) is an effective treatment for posttraumatic stress disorder. During EMDR, patients make horizontal eye movements (EMs) while simultaneously recalling a traumatic memory, which renders the memory less vivid and emotional when it is later recalled again. Recalling highly emotional autobiographical memories enhances noradrenergic neurotransmission. Noradrenaline (NA) strengthens memory (re)consolidation. However, memories become less vivid after recall+EMs...
March 28, 2017: Biological Psychiatry
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