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Memory reconsolidation

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https://www.readbyqxmd.com/read/28096495/memory-disrupting-effects-of-nonmuscle-myosin-ii-inhibition-depend-on-the-class-of-abused-drug-and-brain-region
#1
Sherri B Briggs, Ashley M Blouin, Erica J Young, Gavin Rumbaugh, Courtney A Miller
Depolymerizing actin in the amygdala through nonmuscle myosin II inhibition (NMIIi) produces a selective, lasting, and retrieval-independent disruption of the storage of methamphetamine-associated memories. Here we report a similar disruption of memories associated with amphetamine, but not cocaine or morphine, by NMIIi. Reconsolidation appeared to be disrupted with cocaine. Unlike in the amygdala, methamphetamine-associated memory storage was not disrupted by NMIIi in the hippocampus, nucleus accumbens, or orbitofrontal cortex...
February 2017: Learning & Memory
https://www.readbyqxmd.com/read/28067617/role-of-protein-synthesis-and-dna-methylation-in-the-consolidation-and-maintenance-of-long-term-memory-in-aplysia
#2
Kaycey Pearce, Diancai Cai, Adam C Roberts, David L Glanzman
Previously, we reported that long-term memory (LTM) in Aplysia can be reinstated by truncated (partial) training following its disruption by reconsolidation blockade and inhibition of PKM (Chen et al., 2014). Here, we report thatLTM can be induced by partial training after disruption of original consolidation by protein synthesis inhibition (PSI) begun shortly after training. But when PSI occurs during training, partial training cannot subsequently establish LTM. Furthermore, we find that inhibition of DNA methyltransferase (DNMT), whether during training or shortly afterwards, blocks consolidation of LTM and prevents its subsequent induction by truncated training; moreover, later inhibition of DNMT eliminates consolidated LTM...
January 9, 2017: ELife
https://www.readbyqxmd.com/read/28065842/fear-extinction-and-memory-reconsolidation-as-critical-components-in-behavioral-treatment-for-posttraumatic-stress-disorder-and-potential-augmentation-of-these-processes
#3
REVIEW
Noelle B Smith, Jennifer M Doran, Lauren M Sippel, Ilan Harpaz-Rotem
Posttraumatic stress disorder (PTSD) is associated with alterations in critical brain regions such as the amygdala, hippocampus, and prefrontal cortex. This brief review has two objectives: (1) to discuss research examining extinction and reconsolidation processes as mechanisms in PTSD psychotherapy, and (2) present possibilities for augmenting extinction and reconsolidation within treatment through alterations to therapeutic interventions and novel approaches. A key component of many effective PTSD therapies is exposure, which involves intentional confrontation and processing of the traumatic memory...
January 5, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28042872/infralimbic-glun2a-containing-nmda-receptors-modulate-reconsolidation-of-cocaine-self-administration-memory
#4
Madalyn Hafenbreidel, Carolynn Rafa Todd, Devin Mueller
Addiction is characterized by high relapse susceptibility, and relapse can be triggered by drug-associated cues. Cue presentation induces retrieval of the drug-cue memory, which becomes labile and must be reconsolidated into long-term storage. Repeated unpaired cue presentation, however, induces extinction. Cue-reactivity can be reduced by blocking reconsolidation or facilitating extinction, which are mediated by NMDA receptors (NMDArs). However, the role of NMDArs in either process following self-administration is unclear...
January 2, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28039087/inhibition-of-transcription-and-translation-in-the-striatum-after-memory-reactivation-lack-of-evidence-of-reconsolidation
#5
Roberto A Prado-Alcalá, Andrea Cristina Medina, Paola C Bello-Medina, Gina L Quirarte
It has been found that interference with neural activity after a consolidated memory is retrieved produces an amnestic state; this has been taken has indicative of destabilization of the memory trace that would have been produced by a process of reconsolidation (allowing for maintenance of the original trace). However, a growing body of evidence shows that this is not a reliable effect, and that it is dependent upon some experimental conditions, such as the age of the memory, memory reactivation procedures, the predictability of the reactivation stimulus, and strength of training...
December 27, 2016: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28034785/modulation-of-the-consolidation-and-reconsolidation-of-fear-memory-by-three-different-serotonin-receptors-in-hippocampus
#6
S D Schmidt, C R G Furini, C G Zinn, L E Cavalcante, F F Ferreira, J A K Behling, J C Myskiw, I Izquierdo
The process of memory formation is complex and highly dynamic. During learning, the newly acquired information is found in a fragile and labile state. Through a process known as consolidation, which requires specific mechanisms such as protein synthesis, the memory trace is stored and stabilized. It is known that when a consolidated memory is recalled, it again becomes labile and sensitive to disruption. To be maintained, this memory must undergo an additional process of restabilization called reconsolidation, which requires another phase of protein synthesis...
December 27, 2016: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28034784/altered-ampa-receptor-expression-plays-an-important-role-in-inducing-bidirectional-synaptic-plasticity-during-contextual-fear-memory-reconsolidation
#7
Subhrajit Bhattacharya, Whitney Kimble, Manal Buabeid, Dwipayan Bhattacharya, Jenna Bloemer, Ahmad Alhowail, Miranda Reed, Muralikrishnan Dhanasekaran, Martha Escobar, Vishnu Suppiramaniam
Retrieval of a memory appears to render it unstable until the memory is once again re-stabilized or reconsolidated. Although the occurrence and consequences of reconsolidation have received much attention in recent years, the specific mechanisms that underlie the process of reconsolidation have not been fully described. Here, we present the first electrophysiological model of the synaptic plasticity changes underlying the different stages of reconsolidation of a conditioned fear memory. In this model, retrieval of a fear memory results in immediate but transient alterations in synaptic plasticity, mediated by modified expression of the glutamate receptor subunits GluA1 and GluA2 in the hippocampus of rodents...
December 27, 2016: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28025069/does-reactivation-trigger-episodic-memory-change-a-meta-analysis
#8
Iiona D Scully, Lucy E Napper, Almut Hupbach
According to the reconsolidation hypothesis, long-term memories return to a plastic state upon their reactivation, leaving them vulnerable to interference effects and requiring re-storage processes or else these memories might be permanently lost. The present study used a meta-analytic approach to critically evaluate the evidence for reactivation-induced changes in human episodic memory. Results indicated that reactivation makes episodic memories susceptible to physiological and behavioral interference. When applied shortly after reactivation, interference manipulations altered the amount of information that could be retrieved from the original learning event...
December 23, 2016: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28024275/stress-disrupts-the-reconsolidation-of-fear-memories-in-men
#9
Shira Meir Drexler, Oliver T Wolf
Reconsolidation is a post-retrieval process of restabilization of the memory trace. Previous findings from our group suggest that cortisol, a glucocorticoid hormone secreted in response to stress, enhances the reconsolidation of fear memories in healthy men. Cortisol effect was found to be very specific, enhancing only the fear memory that was reactivated (i.e. retrieved), but not the non-reactivated memory. In the current study we aimed to investigate the effects of psychosocial stress, a more ecologically valid intervention, on fear memory reconsolidation in men...
November 25, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28018227/bidirectional-effects-of-cannabidiol-on-contextual-fear-memory-extinction
#10
Chenchen Song, Carl W Stevenson, Francisco S Guimaraes, Jonathan L C Lee
Cannabidiol (CBD) has been established to have both acute and long-lasting effects to reduce fear memory expression. The long-lasting impact might be mediated by an enhancement of memory extinction or an impairment of memory reconsolidation. Here, we directly compared the effects of i.p. injections of cannabidiol (10 mg/kg) with those of the NMDA receptor antagonist MK-801 (0.1 mg/kg) and partial agonist D-cycloserine (DCS; 15 mg/kg) in order to determine the mnemonic basis of long-term fear reduction. We showed that under conditions of strong fear conditioning, CBD reduced contextual fear memory expression both acutely during the extinction session as well as later at a fear retention test...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28017817/towards-a-better-understanding-on-the-role-of-prediction-error-on-memory-processes-from-bench-to-clinic
#11
María C Krawczyk, Rodrigo S Fernández, María E Pedreira, Mariano M Boccia
psychology defines Prediction Error (PE) as a mismatch between expected and current events. It represents a unifier concept within the memory field, as it is the driving force of memory acquisition and updating. Prediction error induces updating of consolidated memories in strength or content by memory reconsolidation. This process has two different neurobiological phases, which involves the destabilization (labilization) of a consolidated memory followed by its restabilization. The aim of this work is to emphasize the functional role of PE on the neurobiology of learning and memory, integrating and discussing different research areas: behavioural, neurobiological, computational and clinical psychiatry...
December 22, 2016: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28011191/determinants-to-trigger-memory-reconsolidation-the-role-of-retrieval-and-updating-information
#12
Carlos J Rodriguez-Ortiz, Federico Bermúdez-Rattoni
Long-term memories can undergo destabilization/restabilization processes, collectively called reconsolidation. However, the parameters that trigger memory reconsolidation are poorly understood and are a matter of intense investigation. Particularly, memory retrieval is widely held as requisite to initiate reconsolidation. This assumption makes sense since only relevant cues will induce reconsolidation of a specific memory. However, recent studies show that pharmacological inhibition of retrieval does not avoid memory from undergoing reconsolidation, indicating that memory reconsolidation occurs through a process that can be dissociated from retrieval...
December 21, 2016: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28003127/consolidation-and-reconsolidation-are-impaired-by-oral-propranolol-administered-before-but-not-after-memory-re-activation-in-humans
#13
Émilie Thomas, Daniel Saumier, Roger K Pitman, Jacques Tremblay, Alain Brunet
Propranolol administered immediately after learning or after recall has been found to impair memory consolidation or reconsolidation (respectively) in animals, but less reliably so in humans. Since reconsolidation impairment has been proposed as a treatment for mental disorders that have at their core an emotional memory, it is desirable to understand how to reliably reduce the strength of pathogenic memories in humans. We postulated that since humans (unlike experimental animals) typically receive propranolol orally, this introduces a delay before this drug can exert its memory impairment effects, which may render it less effective...
December 18, 2016: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/27987370/cued-memory-reconsolidation-in-rats-requires-nitric-oxide
#14
Natalia Bal, Mariia P Rysakova, Alia K Vinarskaya, Violetta Ivanova, Alena B Zuzina, Pavel M Balaban
It is well known that the reactivation of consolidated fear memory under boundary conditions of novelty and protein synthesis blockade results in an impairment of memory, suggesting that the reactivated memory is destabilised and requires synthesis of new proteins for reconsolidation. We tested the hypothesis of nitric oxide (NO) involvement in memory destabilization during the reconsolidation process in rats using memory reactivation under different conditions. We report that administration of NO-synthase selective blockers 3-Br-7-NI or ARL in the conditions of reactivation of memory under a protein synthesis blockade prevented destabilisation of fear memory to the conditioned stimulus...
December 17, 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27932983/cannabidiol-regulation-of-learned-fear-implications-for-treating-anxiety-related-disorders
#15
Regimantas Jurkus, Harriet L L Day, Francisco S Guimarães, Jonathan L C Lee, Leandro J Bertoglio, Carl W Stevenson
Anxiety and trauma-related disorders are psychiatric diseases with a lifetime prevalence of up to 25%. Phobias and post-traumatic stress disorder (PTSD) are characterized by abnormal and persistent memories of fear-related contexts and cues. The effects of psychological treatments such as exposure therapy are often only temporary and medications can be ineffective and have adverse side effects. Growing evidence from human and animal studies indicates that cannabidiol, the main non-psychotomimetic phytocannabinoid present in Cannabis sativa, alleviates anxiety in paradigms assessing innate fear...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27919830/newly-acquired-and-reactivated-contextual-fear-memories-are-more-intense-and-prone-to-generalize-after-activation-of-prelimbic-cortex-nmda-receptors
#16
Ana C Vanvossen, Marina A M Portes, Rafael Scoz-Silva, Hugo B Reichmann, Cristina A J Stern, Leandro J Bertoglio
Activity in the rodent prelimbic (PL) cortex contributes to consolidation, retrieval and reconsolidation of learned fear. The PL cortex is considered homologous to the primate dorsal anterior cingulate cortex (dACC). In patients with post-traumatic stress disorder (PTSD), the dACC is often reported to be hyperactive after acquisition and/or around the retrieval of the traumatic memory. It is still unknown, however, whether there is a relationship between altered dACC functioning at these time points and PTSD-associated behavioral outcomes, such as fear overgeneralization...
January 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/27918276/repeated-recall-and-pkm%C3%AE-maintain-fear-memories-in-juvenile-rats
#17
Chicora F Oliver, Patricia Kabitzke, Peter Serrano, Laura J Egan, Gordon A Barr, Harry N Shair, Christoph Wiedenmayer
We examined the neural substrates of fear memory formation and maintenance when repeated recall was used to prevent forgetting in young animals. In contrast to adult rats, juveniles failed to show contextual fear responses at 4 d post-fear conditioning. Reconsolidation sessions 3 and 6 d after conditioning restored contextual fear responses in juveniles 7 d after initial training. In juveniles that received reconsolidation sessions, protein kinase M zeta (PKMζ) increased in the amygdala, but not in the hippocampus...
December 2016: Learning & Memory
https://www.readbyqxmd.com/read/27885549/memory-reconsolidation
#18
Josue Haubrich, Karim Nader
Scientific advances in the last decades uncovered that memory is not a stable, fixed entity. Apparently stable memories may become transiently labile and susceptible to modifications when retrieved due to the process of reconsolidation. Here, we review the initial evidence and the logic on which reconsolidation theory is based, the wide range of conditions in which it has been reported and recent findings further revealing the fascinating nature of this process. Special focus is given to conceptual issues of when and why reconsolidation happen and its possible outcomes...
November 25, 2016: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/27871996/the-role-of-glucocorticoids-in-emotional-memory-reconsolidation-review
#19
REVIEW
Shira Meir Drexler, Oliver T Wolf
Glucocorticoids are secreted following exposure to stressful events. Their modulating role on memory reconsolidation, a post-retrieval process of re-stabilization, has been investigated only recently, at times with conflicting results. The goal of this review is twofold. First, to establish the modulating role of glucocorticoids on memory reconsolidation. Second, to point the potential factors and confounds that might explain the seemingly paradoxical findings. Here we review recent pharmacological studies, conducted in rodents and humans, which suggest a critical role of glucocorticoids in this post-retrieval process...
November 18, 2016: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/27869801/direct-dorsal-hippocampal-prelimbic-cortex-connections-strengthen-fear-memories
#20
Xiaojing Ye, Dana Kapeller-Libermann, Alessio Travaglia, M Carmen Inda, Cristina M Alberini
The ability to regulate the consolidation and strengthening of memories for threatening experiences is critical for mental health, and its dysregulation may lead to psychopathologies. Re-exposure to the context in which the threat was experienced can either increase or decrease fear response through distinct processes known, respectively, as reconsolidation or extinction. Using a context retrieval-dependent memory-enhancement model in rats, we report that memory strengthens through activation of direct projections from dorsal hippocampus to prelimbic (PL) cortex and activation of critical PL molecular mechanisms that are not required for extinction...
January 2017: Nature Neuroscience
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