keyword
MENU ▼
Read by QxMD icon Read
search

Memory consolidation

keyword
https://www.readbyqxmd.com/read/29908972/bidirectional-relationships-between-sleep-and-amyloid-beta-in-the-hippocampus
#1
Julien Dufort-Gervais, Valérie Mongrain, Jonathan Brouillette
Alzheimer's disease (AD) is a debilitating neurodegenerative disease characterized by progressive hippocampal-dependent explicit memory deficits that begin at the onset of the illness. An early hallmark of AD is the accumulation of amyloid-beta (Aß) proteins in brain structures involved in encoding and consolidation of memory, like the hippocampus and prefrontal cortex. Aß neurotoxicity is known to induce synaptic dysfunctions and neuronal death leading to cognitive decline. Another recurrent event observed in AD is sleep disturbances...
June 14, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29906574/do-different-salience-cues-compete-for-dominance-in-memory-over-a-daytime-nap
#2
Sara E Alger, Shirley Chen, Jessica D Payne
Information that is the most salient and important for future use is preferentially preserved through active processing during sleep. Emotional salience is a biologically adaptive cue that influences episodic memory processing through interactions between amygdalar and hippocampal activity. However, other cues that influence the importance of information, such as the explicit direction to remember or forget, interact with the inherent salience of information to determine its fate in memory. It is unknown how sleep-based processes selectively consolidate this complex information...
June 12, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29899451/quantitative-phosphoproteomic-analysis-of-the-molecular-substrates-of-sleep-need
#3
Zhiqiang Wang, Jing Ma, Chika Miyoshi, Yuxin Li, Makito Sato, Yukino Ogawa, Tingting Lou, Chengyuan Ma, Xue Gao, Chiyu Lee, Tomoyuki Fujiyama, Xiaojie Yang, Shuang Zhou, Noriko Hotta-Hirashima, Daniela Klewe-Nebenius, Aya Ikkyu, Miyo Kakizaki, Satomi Kanno, Liqin Cao, Satoru Takahashi, Junmin Peng, Yonghao Yu, Hiromasa Funato, Masashi Yanagisawa, Qinghua Liu
Sleep and wake have global effects on brain physiology, from molecular changes1-4 and neuronal activities to synaptic plasticity3-7 . Sleep-wake homeostasis is maintained by the generation of a sleep need that accumulates during waking and dissipates during sleep8-11 . Here we investigate the molecular basis of sleep need using quantitative phosphoproteomic analysis of the sleep-deprived and Sleepy mouse models of increased sleep need. Sleep deprivation induces cumulative phosphorylation of the brain proteome, which dissipates during sleep...
June 13, 2018: Nature
https://www.readbyqxmd.com/read/29891765/randomized-controlled-trial-considering-varied-exercises-for-reducing-proactive-memory-interference
#4
Emily Frith, Eveleen Sng, Paul D Loprinzi
We evaluated the effects of exercise on proactive memory interference. Study 1 ( n = 88) employed a 15-min treadmill walking protocol, while Study 2 ( n = 88) included a 15-min bout of progressive maximal exertion treadmill exercise. Each study included four distinct groups, in which groups of 22 participants each were randomly assigned to: (a) exercise before memory encoding, (b) a control group with no exercise, (c) exercise during memory encoding, and (d) exercise after memory encoding (i.e., during memory consolidation)...
June 11, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29887312/spatial-memory-engram-in-the-mouse-retrosplenial-cortex
#5
Michal M Milczarek, Seralynne D Vann, Frank Sengpiel
Memory relies on lasting adaptations of neuronal properties elicited by stimulus-driven plastic changes [1]. The strengthening (and weakening) of synapses results in the establishment of functional ensembles. It is presumed that such ensembles (or engrams) are activated during memory acquisition and re-activated upon memory retrieval. The retrosplenial cortex (RSC) has emerged as a key brain area supporting memory [2], including episodic and topographical memory in humans [3-5], as well as spatial memory in rodents [6, 7]...
May 30, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29885420/sub-efficacious-doses-of-phosphodiesterase-4-and-5-inhibitors-improve-memory-in-a-mouse-model-of-alzheimer-s-disease
#6
Walter Gulisano, Maria Rosaria Tropea, Ottavio Arancio, Agostino Palmeri, Daniela Puzzo
Cyclic nucleotides cAMP and cGMP cooperate to ensure memory acquisition and consolidation. Increasing their levels by phosphodiesterase inhibitors (PDE-Is) enhanced cognitive functions and rescued memory loss in different models of aging and Alzheimer's disease (AD). However, side effects due to the high doses used limited their application in humans. Based on previous studies suggesting that combinations of sub-efficacious doses of cAMP- and cGMP-specific PDE-Is improved synaptic plasticity and memory in physiological conditions, here we aimed to study whether this treatment was effective to counteract the AD phenotype in APPswe mice...
June 6, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29883710/a-brief-period-of-eyes-closed-rest-enhances-motor-skill-consolidation
#7
Graelyn B Humiston, Erin J Wamsley
Post-training sleep benefits both declarative and procedural memory consolidation. However, recent research suggests that eyes-closed waking rest may provide a similar benefit. Brokaw et al. (2016), for example, recently demonstrated that verbal declarative memory improved more following a 15min period of waking rest, in comparison to 15min of active wake. Here, we used the same procedures to test whether procedural memory similarly benefits from waking rest. Participants were trained on the Motor Sequence Task (MST), followed by a 15min retention interval during which they either rested with their eyes closed or completed a distractor task...
June 5, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29880391/bombesin-induced-enhancement-of-memory-consolidation-in-male-and-female-rat-pups-role-of-glutamatergic-and-dopaminergic-systems
#8
Ali Ghanbari, Nasroallah Moradi Kor, Ali Rashidy-Pour
Previous studies have shown that the neuropeptide bombesin (BBS) enhances consolidation of specifically for inhibitory avoidance memory in adult rats. However, its effect on memory consolidation during premature period is not clear as well. Thus, this study evaluated the effect of BBS and its interaction with glutamatergic and dopaminergic systems on memory consolidation in rat pups. Male and female rat pups (30 days old) were trained in an inhibitory avoidance (IA) task (0.5 mA, 3 s footshock). Memory retention was tested 24 h later during which the latency to re-enter to the shock compartment was recorded...
June 1, 2018: Neuropeptides
https://www.readbyqxmd.com/read/29879564/mechanisms-underlying-the-association-between-insomnia-anxiety-and-depression-in-adolescence-implications-for-behavioral-sleep-interventions
#9
REVIEW
Matthew J Blake, John A Trinder, Nicholas B Allen
There is robust evidence of an association between insomnia, anxiety, and depression in adolescence. The aim of this review is to describe and synthesize potential mechanisms underlying this association and explore implications for the design of adolescent behavioral sleep interventions. Specifically, we examine whether insomnia symptoms are a mechanism for the development of internalizing symptoms in adolescence and whether sleep interventions are an effective treatment for both insomnia and internalizing symptoms in adolescence because they target the shared mechanisms underlying these disorders...
May 28, 2018: Clinical Psychology Review
https://www.readbyqxmd.com/read/29878804/role-of-retrosplenial-cortex-in-processing-stress-related-context-memories
#10
Kevin A Corcoran, Naoki Yamawaki, Katherine Leaderbrand, Jelena Radulovic
This work summarizes evidence for the role of RSC in processing fear-inducing context memories. Specifically, we discuss molecular, cellular, and network mechanisms by which RSC might contribute the processing of contextual fear memories. We focus on glutamatergic and cholinergic mechanisms underlying encoding, retrieval, and extinction of context-dependent fear. RSC mechanisms underlying retrieval of recently and remotely acquired memories are compared to memory mechanisms of anterior cortices. Due to the strong connectivity between hippocampus and RSC, we also compare the extent to which their mechanisms of encoding, retrieval, and extinction show overlap...
June 7, 2018: Behavioral Neuroscience
https://www.readbyqxmd.com/read/29875390/the-dynamic-interplay-between-acute-psychosocial-stress-emotion-and-autobiographical-memory
#11
Signy Sheldon, Sonja Chu, Jonas P Nitschke, Jens C Pruessner, Jennifer A Bartz
Although acute psychosocial stress can impact autobiographical memory retrieval, the nature of this effect is not entirely clear. One reason for this ambiguity is because stress can have opposing effects on the different stages of autobiographical memory retrieval. We addressed this issue by testing how acute stress affects three stages of the autobiographical memory retrieval - accessing, recollecting and reconsolidating a memory. We also investigate the influence of emotion valence on this effect. In a between-subjects design, participants were first exposed to an acute psychosocial stressor or a control task...
June 6, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29872969/the-relationship-between-sleep-and-cognitive-function-in-patients-with-prediabetes-and-type-2-diabetes
#12
Sunee Saetung, Hataikarn Nimitphong, Nantaporn Siwasaranond, Rungtip Sumritsopak, Panitha Jindahra, Orapitchaya Krairit, Ammarin Thakkinstian, Thunyarat Anothaisintawee, Sirimon Reutrakul
AIMS: Diabetes is linked to cognitive impairment. Sleep plays a role in memory consolidation. Sleep disturbances, commonly found in patients with diabetes, were shown to be related to cognitive dysfunction. This study explored the role of sleep in cognitive function of patients with abnormal glucose tolerance. METHODS: A total of 162 patients (81 type 2 diabetes and 81 prediabetes) participated. Sleep duration and sleep efficiency (an indicator of sleep quality) were obtained using 7-day actigraphy recordings...
June 6, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29872376/dissociated-role-of-d-serine-in-extinction-during-consolidation-vs-reconsolidation-of-context-conditioned-fear
#13
Ran Inoue, Gourango Talukdar, Keizo Takao, Tsuyoshi Miyakawa, Hisashi Mori
Extinction-based exposure therapy is widely used for the treatment of anxiety disorders, such as post-traumatic stress disorder (PTSD). D-serine, an endogenous co-agonist at the glycine-binding site of the N -methyl-D-aspartate-type glutamate receptor (NMDAR), has been shown to be involved in extinction of fear memory. Recent findings suggest that the length of time between the initial learning and an extinction session is a determinant of neural mechanism involved in fear extinction. However, how D-serine is involved in extinction of fear memory at different timings remains unclear...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29870702/sleep-spindles-timed-for-memory-consolidation
#14
Monika Schönauer
It has long been known that sleep supports memory consolidation. Two recent studies now shed light on how sleep spindles, characteristic 11-16 Hz activity bursts, contribute critically to memory processing during the night.
June 4, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29869611/uncovering-temporal-structure-in-hippocampal-output-patterns
#15
Kourosh Maboudi, Etienne Ackermann, Laurel Watkins de Jong, Brad Pfeiffer, David Foster, Kamran Diba, Caleb Kemere
Place cell activity of hippocampal pyramidal cells has been described as the cognitive substrate of spatial memory. Replay is observed during hippocampal sharp-wave-ripple-associated population burst events (PBEs) and is critical for consolidation and recall-guided behaviors. PBE activity has historically been analyzed as a phenomenon subordinate to the place code. Here, we use hidden Markov models to study PBEs observed in rats during exploration of both linear mazes and open fields. We demonstrate that estimated models are consistent with a spatial map of the environment, and can even decode animals' positions during behavior...
June 5, 2018: ELife
https://www.readbyqxmd.com/read/29867439/age-related-decrease-in-stress-responsiveness-and-proactive-coping-in-male-mice
#16
Hee-Jin Oh, Minah Song, Young Ki Kim, Jae Ryong Bae, Seung-Yun Cha, Ji Young Bae, Yeongmin Kim, Minsu You, Younpyo Lee, Jieun Shim, Sungho Maeng
Coping is a strategic approach to dealing with stressful situations. Those who use proactive coping strategies tend to accept changes and act before changes are expected. In contrast, those who use reactive coping are less flexible and more likely to act in response to changes. However, little research has assessed how coping style changes with age. This study investigated age-related changes in coping strategies and stress responsiveness and the influence of age on the processing of conditioned fear memory in 2-, 12- and 23-month-old male mice...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29867116/reward-enhanced-encoding-improves-relearning-of-forgotten-associations
#17
Ewa A Miendlarzewska, Sara Ciucci, Carlo V Cannistraci, Daphne Bavelier, Sophie Schwartz
Research on human memory has shown that monetary incentives can enhance hippocampal memory consolidation and thereby protect memory traces from forgetting. However, it is not known whether initial reward may facilitate the recovery of already forgotten memories weeks after learning. Here, we investigated the influence of monetary reward on later relearning. Nineteen healthy human participants learned object-location associations, for half of which we offered money. Six weeks later, most of these associations had been forgotten as measured by a test of declarative memory...
June 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29863444/when-they-become-us-the-effect-of-time-and-ingroup-identity-on-perceptions-of-gay-and-lesbian-group-members
#18
Amber K Lupo, Michael A Zárate
Prejudice change manipulations rarely produce the expected attitude change effects. Our research suggests that attitude change depends on time-dependent memory consolidation processes. This study tested the effects of group information and time on perceptions of gays and lesbians. Heterosexual participants (N = 90) were randomly assigned to a condition where their ingroup, or an outgroup, included gay and lesbian individuals. We measured participants' gay and lesbian political attitudes and evaluations of the groups' members at a short- or long-delay...
June 4, 2018: Journal of Homosexuality
https://www.readbyqxmd.com/read/29860001/inhibition-of-histone-deacetylase-3-via-rgfp966-facilitates-cortical-plasticity-underlying-unusually-accurate-auditory-associative-cue-memory-for-excitatory-and-inhibitory-cue-reward-associations
#19
Andrea Shang, Sooraz Bylipudi, Kasia M Bieszczad
Epigenetic mechanisms are key for regulating long-term memory (LTM) and are known to exert control on memory formation in multiple systems of the adult brain, including the sensory cortex. One epigenetic mechanism is chromatin modification by histone acetylation. Blocking the action of histone de-acetylases (HDACs) that normally negatively regulate LTM by repressing transcription, has been shown to enable memory formation. Indeed, HDAC-inhibition appears to facilitate memory by altering the dynamics of gene expression events important for memory consolidation...
May 31, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29849564/context-and-time-matter-effects-of-emotion-and-motivation-on-episodic-memory-overtime
#20
Qing Sun, Simeng Gu, Jiongjiong Yang
Previous studies have shown that compared with neutral cues, stimuli with positive and negative/stressful contexts or reward and punishment cues are remembered better. However, it is unclear whether the enhanced effect differs in emotion or motivation dimensions and the passage of time. We addressed these issues by manipulating different contextual cues for neutral words at different time intervals. In experiment 1, subjects were asked to learn words with picture contexts in positive, negative/stressful, and neutral valences and were tested by old/new word recognition and contextual judgment 10 min, 1 day, and 1 week later...
2018: Neural Plasticity
keyword
keyword
31526
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"