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https://www.readbyqxmd.com/read/28228742/sleep-dependent-consolidation-of-rewarded-behavior-is-diminished-in-children-with-attention-deficit-hyperactivity-disorder-and-a-comorbid-disorder-of-social-behavior
#1
Christian D Wiesner, Ina Molzow, Alexander Prehn-Kristensen, Lioba Baving
Children suffering from attention-deficit hyperactivity disorder (ADHD) often also display impaired learning and memory. Previous research has documented aberrant reward processing in ADHD as well as impaired sleep-dependent consolidation of declarative memory. We investigated whether sleep also fosters the consolidation of behavior learned by probabilistic reward and whether ADHD patients with a comorbid disorder of social behavior show deficits in this memory domain, too. A group of 17 ADHD patients with comorbid disorders of social behavior aged 8-12 years and healthy controls matched for age, IQ, and handedness took part in the experiment...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28227755/differentiation-of-spindle-associated-hippocampal-hfos-based-on-a-correlation-analysis
#2
Daniel Lachner Piza, Jonas C Bruder, Julia Jacobs, Andreas Schulze-Bonhage, Thomas Stieglitz, Matthias Dumpelmann, Daniel Lachner Piza, Jonas C Bruder, Julia Jacobs, Andreas Schulze-Bonhage, Thomas Stieglitz, Matthias Dumpelmann, Thomas Stieglitz, Matthias Dumpelmann, Jonas C Bruder, Andreas Schulze-Bonhage, Daniel Lachner Piza, Julia Jacobs
High Frequency Oscillations (HFOs) have been described as biomarkers of epileptogenic tissue; however their pathological/physiological classification poses a challenge to their predictive power. For the population of ripples co-occurring with sleep spindles, those ripples improving the antiparallel correlation of ripple-peaks and sleep spindle-troughs were classified as coupled-ripples and the rest as uncoupled-ripples. For the same population of ripples two reference groups called in-SOZ and non-SOZ were formed according to the ripples' location inside or outside the seizure onset zone (SOZ)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28219752/sleep-does-not-facilitate-insight-in-older-adults
#3
Ursula Debarnot, Marta Rossi, Sophie Schwartz, Ugo Faraguna, Laura Sebastiani
Sleep has been shown to foster the process of insight generation in young adults during problem solving activities. Aging is characterized by substantial changes in sleep architecture altering memory consolidation. Whether sleep might promote the occurrence of insight in older adults as well has not yet been tested experimentally. To address this issue, we tested healthy young and old volunteers on an insight problem solving task, involving both explicit and implicit features, before and after a night of sleep or a comparable wakefulness period...
February 17, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28219076/effect-of-n-benzylpiperazine-its-metabolite-n-benzylethylenediamine-and-its-disubstituted-analogue-n-n-dibenzylpiperazine-on-the-acquisition-formation-and-consolidation-of-memory-in-mice
#4
Juan Carlos Castillo-Hernández, Josué A Velázquez-Moyado, Adelfo Reyes-Ramírez, Elena G Ramírez-López, Martín González-Andrade, Andrés Navarrete
BACKGROUND: N-benzylpiperazine (BZP) belongs to a class of piperazine derivatives (PZDs) that have emerged as recreational drugs. These compounds increase the release of dopamine and serotonin. BZP mimics the psychoactive effects of 3,4-methylenedioxymethylamphetamine. BZP is metabolized to N-benzylethylenediamine (BEDA) and benzylamine. The compound N,N'-dibenzylpiperazine (DBZP) is obtained as a byproduct during the synthesis of BZP. Some PZDs have shown effects on memory; however, there are no previous reports on the activity of BZP, BEDA, and DBZP on memory or on a description of their neuropharmacological profile...
February 21, 2017: Pharmacology
https://www.readbyqxmd.com/read/28215308/releasing-mechanism-of-neurotrophic-factors-via-polysialic-acid
#5
C Sato
Neurotrophins are well-characterized neurologically active molecules in the central nervous system. The regulation of these signaling molecules, which are involved in cell growth, differentiation, and survival, is critical for normal brain function. Among the different types of neurotrophins, brain-derived neurotrophic factor (BDNF) is involved in various brain functions, including memory consolidation, synaptic plasticity, and adult neurogenesis, and is therefore a key molecule for understanding comprehensive brain function and neurodevelopmental and psychiatric diseases...
2017: Vitamins and Hormones
https://www.readbyqxmd.com/read/28213398/foxo-integration-of-insulin-signaling-with-glucose-and-lipid-metabolism
#6
Sojin Lee, Henry H Dong
The forkhead box O family consists of FoxO1, FoxO3, FoxO4 and FoxO6 proteins in mammals. Expressed ubiquitously in the body, the four FoxO isoforms share in common the amino DNA binding domain, known as "forkhead box" domain. They mediate the inhibitory action of insulin or insulin-like growth factor on key functions involved in cell metabolism, growth, differentiation, oxidative stress, senescence, autophagy and aging. Genetic mutations in FoxO genes or abnormal expression of FoxO proteins are associated with metabolic disease, cancer or altered lifespan in humans and animals...
February 17, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28213162/the-effect-of-lamotrigine-on-learning-in-mice-using-the-passive-avoidance-model
#7
Fatemeh Izadpanah, Fatemeh Arab, Amin Zarghami, Ali Bijani, Sohrab Kazemi, Ali Akbar Moghadamnia
INTRODUCTION: Lamotrigine (LTG) is an antiepileptic drug that inhibits the release of glutamate by blocking sodium channels. The present study was conducted to evaluate the effect of LTG in different stages of memory using a passive avoidance learning task in mice. METHODS: Male albino mice in the weight range 20-25g were used. They were divided into four groups (control group and three groups receiving various doses of LTG). LTG was given in three doses of 10, 25, and 50mg/kg as intraperitoneal (IP) injections...
February 14, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28212946/divergent-effects-of-brain-interleukin-1%C3%A3-in-mediating-fever-lethargy-anorexia-and-conditioned-fear-memory
#8
Tamzyn L Baartman, Tanya Swanepoel, Ruth M Barrientos, Helen P Laburn, Duncan Mitchell, Lois M Harden
The influence of brain interleukin-1 (IL-1ß) on memory processes includes both detrimental and beneficial effects. To further explore the dynamics of brain IL-1ß in mediating learning and memory during acute sickness, we injected species-homologous rat IL-1ß (100ng/5μl) or vehicle (0.1% bovine serum albumin, 5μl) directly into the cisterna magna (i.c.m.) of male Sprague-Dawley rats. We measured, in parallel, body temperature, food intake, body mass, cage activity, as well as learning and memory using contextual fear conditioning...
February 14, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28211489/sleep-supports-the-slow-abstraction-of-gist-from-visual-perceptual-memories
#9
Nicolas D Lutz, Susanne Diekelmann, Patricia Hinse-Stern, Jan Born, Karsten Rauss
Sleep benefits the consolidation of individual episodic memories. In the long run, however, it may be more efficient to retain the abstract gist of single, related memories, which can be generalized to similar instances in the future. While episodic memory is enhanced after one night of sleep, effective gist abstraction is thought to require multiple nights. We tested this hypothesis using a visual Deese-Roediger-McDermott paradigm, examining gist abstraction and episodic-like memory consolidation after 20 min, after 10 hours, as well as after one year of retention...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28207863/identification-of-age-dependent-motor-and-neuropsychological-behavioural-abnormalities-in-a-mouse-model-of-mucopolysaccharidosis-type-ii
#10
Hélène F E Gleitz, Claire O'Leary, Rebecca J Holley, Brian W Bigger
Severe mucopolysaccharidosis type II (MPS II) is a progressive lysosomal storage disease caused by mutations in the IDS gene, leading to a deficiency in the iduronate-2-sulfatase enzyme that is involved in heparan sulphate and dermatan sulphate catabolism. In constitutive form, MPS II is a multi-system disease characterised by progressive neurocognitive decline, severe skeletal abnormalities and hepatosplenomegaly. Although enzyme replacement therapy has been approved for treatment of peripheral organs, no therapy effectively treats the cognitive symptoms of the disease and novel therapies are in development to remediate this...
2017: PloS One
https://www.readbyqxmd.com/read/28206646/acute-melamine-affects-spatial-memory-consolidation-via-inhibiting-hippocampal-nmdar-dependent-ltd-in-rats
#11
Lei An, Wei Sun
No abstract text is available yet for this article.
February 16, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28202719/sleep-enhances-knowledge-of-routes-and-regions-in-spatial-environments
#12
Hannes Noack, Wiebke Schick, Hanspeter Mallot, Jan Born
Sleep is thought to preferentially consolidate hippocampus-dependent memory, and as such, spatial navigation. Here, we investigated the effects of sleep on route knowledge and explicit and implicit semantic regions in a virtual environment. Sleep, compared with wakefulness, improved route knowledge and also enhanced awareness of the semantic regionalization within the environment, whereas signs of implicit regionalization remained unchanged. Results support the view that sleep specifically enhances explicit aspects of memory, also in the spatial domain...
March 2017: Learning & Memory
https://www.readbyqxmd.com/read/28198431/investigation-of-hippocampal-synaptic-transmission-and-plasticity-in-mice-deficient-in-the-actin-binding-protein-drebrin
#13
Claudia G Willmes, Till G A Mack, Julia Ledderose, Dietmar Schmitz, Christian Wozny, Britta J Eickholt
The dynamic regulation of the actin cytoskeleton plays a key role in controlling the structure and function of synapses. It is vital for activity-dependent modulation of synaptic transmission and long-term changes in synaptic morphology associated with memory consolidation. Several regulators of actin dynamics at the synapse have been identified, of which a salient one is the postsynaptic actin stabilising protein Drebrin (DBN). It has been suggested that DBN modulates neurotransmission and changes in dendritic spine morphology associated with synaptic plasticity...
February 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28193862/differential-modulation-of-global-and-local-neural-oscillations-in-rem-sleep-by-homeostatic-sleep-regulation
#14
Bowon Kim, Bernat Kocsis, Eunjin Hwang, Youngsoo Kim, Robert E Strecker, Robert W McCarley, Jee Hyun Choi
Homeostatic rebound in rapid eye movement (REM) sleep normally occurs after acute sleep deprivation, but REM sleep rebound settles on a persistently elevated level despite continued accumulation of REM sleep debt during chronic sleep restriction (CSR). Using high-density EEG in mice, we studied how this pattern of global regulation is implemented in cortical regions with different functions and network architectures. We found that across all areas, slow oscillations repeated the behavioral pattern of persistent enhancement during CSR, whereas high-frequency oscillations showed progressive increases...
February 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28188854/the-effects-of-a-single-bout-of-exercise-on-motor-memory-interference-in-the-trained-and-untrained-hemisphere
#15
Benedikt Lauber, Steffen Franke, Wolfgang Taube, Albert Gollhofer
Increasing evidence suggests that cardiovascular exercise has positive effects on motor memory consolidation. In this study, we investigated whether a single session of high-intensity interval training (HIIT) mitigates the effects of practicing an interfering motor task. Furthermore, learning and interference effects were assessed in the actively trained and untrained limb as it is known that unilateral motor learning can cause bilateral adaptations. Subjects performed a ballistic training and then the HIIT either before (HIIT_before) or after (HIIT_after) practicing an interfering accuracy task (AT)...
February 8, 2017: Neuroscience
https://www.readbyqxmd.com/read/28185871/differential-arc-protein-expression-in-dorsal-and-ventral-striatum-after-moderate-and-intense-inhibitory-avoidance-training
#16
Diego A González-Franco, Víctor Ramírez-Amaya, Patricia Joseph-Bravo, Roberto A Prado-Alcalá, Gina L Quirarte
Intense training refers to training mediated by emotionally arousing experiences, such as aversive conditioning motivated by relatively high intensities of foot-shock, which produces a strong memory that is highly resistant to extinction. Intense training protects memory consolidation against the amnestic effects of a wide variety of treatments, administered systemically or directly into brain structures. The mechanisms of this protective effect are unknown. To determine a potential neurobiological correlate of the protective effect of intense training, rats were trained in a one-trial step-through inhibitory avoidance task using different intensities of foot-shock (0...
February 6, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28178292/differential-requirements-of-hippocampal-de-novo-protein-and-mrna-synthesis-in-two-long-term-spatial-memory-tests-spontaneous-place-recognition-and-delay-interposed-radial-maze-performance-in-rats
#17
Takaaki Ozawa, Kazuo Yamada, Yukio Ichitani
Hippocampal de novo mRNA and protein synthesis has been suggested to be critical for long-term spatial memory. However, its requirement in each memory process (i.e. encoding, consolidation and retrieval) and the differences in the roles of de novo mRNA and protein synthesis in different situations where spatial memory is tested have not been thoroughly investigated. To address these questions, we examined the effects of hippocampal administration of the protein synthesis inhibitors, anisomycin (ANI) and emetine (EME), as well as that of an mRNA synthesis inhibitor, 5,6-dichlorobenzimidazole 1-β-D-ribofuranoside (DRB), on rat performance in two long-term spatial memory tests...
2017: PloS One
https://www.readbyqxmd.com/read/28176659/intrinsically-disordered-domains-amyloids-and-protein-liquid-phases-evolving-concepts-and-open-questions
#18
Miguel Ángel Mompeán, Douglas Vinson Laurents
Enzymes and structural proteins dominated thinking about protein structure and function for most of the twentieth century. In recent decades, however, we have begun to appreciate the significant physiological and pathological roles of nonglobular proteins. Amyloids first gained infamy from their implications in a score of human mortal diseases. However, they have recently been discovered to play vital physiological roles, such as memory consolidation in humans. This raises an important question: Can we inhibit pathological amyloids without affecting functional amyloids? Intrinsically disordered proteins (IDPs), many of which are prone to form amyloids, perform many essential functions, yet their importance has only been recognized in the last quarter century...
February 6, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28176459/reconsolidation-induced-rescue-of-a-remote-fear-memory-blocked-by-an-early-cortical-inhibition-involvement-of-the-anterior-cingulate-cortex-and-the-mediation-by-the-thalamic-nucleus-reuniens
#19
Rodrigo O Sierra, Lizeth K Pedraza, Querusche K Zanona, Fabiana Santana, Flávia Z Boos, Ana P Crestani, Josué Haubrich, Lucas de Oliveira Alvares, Maria Elisa Calcagnotto, Jorge A Quillfeldt
Systems consolidation is a time-dependent reorganization process involving neocortical and hippocampal networks underlying memory storage and retrieval. The involvement of the hippocampus during acquisition is well described, however we know much less about the concomitant contribution of cortical activity levels to the formation of stable remote memories. Here, after a reversible pharmacological inhibition of the anterior cingulate cortex (ACC) during the acquisition of a contextual fear conditioning, retrieval of both recent and remote memories were impaired, an effect that was reverted by a single memory reactivation session 48h after training, through a destabilization-dependent mechanism interpreted as reconsolidation, that restored the normal course of systems consolidation in order to rescue a remote memory...
February 8, 2017: Hippocampus
https://www.readbyqxmd.com/read/28173964/sleep-deprivation-disrupts-the-contribution-of-the-hippocampus-to-the-formation-of-novel-lexical-associations
#20
Virginie Sterpenich, Leonardo Ceravolo, Sophie Schwartz
Sleep is involved in the mechanisms underlying memory consolidation and brain plasticity. Consolidation refers to a process through which labile memories are reorganized into more stable ones. An intriguing but often neglected question concerns how pre-existing knowledge is modified when new information enters memory, and whether sleep can influence this process. We investigated how nonword learning may modify the neural representations of closely-related existing words. We also tested whether sleep contributes to any such effect by comparing a group of participants who slept during the night following a first encoding session to a sleep deprived group...
February 4, 2017: Brain and Language
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