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Memory consolidation

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https://www.readbyqxmd.com/read/29213231/the-roles-of-cortical-slow-waves-in-synaptic-plasticity-and-memory-consolidation
#1
Daisuke Miyamoto, Daichi Hirai, Masanori Murayama
Sleep plays important roles in sensory and motor memory consolidation. Sleep oscillations, reflecting neural population activity, involve the reactivation of learning-related neurons and regulate synaptic strength and, thereby affect memory consolidation. Among sleep oscillations, slow waves (0.5-4 Hz) are closely associated with memory consolidation. For example, slow-wave power is regulated in an experience-dependent manner and correlates with acquired memory. Furthermore, manipulating slow waves can enhance or impair memory consolidation...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/29213077/allosteric-nanobodies-uncover-a-role-of-hippocampal-mglu2-receptor-homodimers-in-contextual-fear-consolidation
#2
Pauline Scholler, Damien Nevoltris, Dimitri de Bundel, Simon Bossi, David Moreno-Delgado, Xavier Rovira, Thor C Møller, Driss El Moustaine, Michaël Mathieu, Emilie Blanc, Heather McLean, Elodie Dupuis, Gérard Mathis, Eric Trinquet, Hervé Daniel, Emmanuel Valjent, Daniel Baty, Patrick Chames, Philippe Rondard, Jean-Philippe Pin
Antibodies have enormous therapeutic and biotechnology potential. G protein-coupled receptors (GPCRs), the main targets in drug development, are of major interest in antibody development programs. Metabotropic glutamate receptors are dimeric GPCRs that can control synaptic activity in a multitude of ways. Here we identify llama nanobodies that specifically recognize mGlu2 receptors, among the eight subtypes of mGluR subunits. Among these nanobodies, DN10 and 13 are positive allosteric modulators (PAM) on homodimeric mGlu2, while DN10 displays also a significant partial agonist activity...
December 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/29209168/direct-neuronal-glucose-uptake-is-required-for-contextual-fear-acquisition-in-the-dorsal-hippocampus
#3
Liang Kong, Yan Zhao, Wen-Juan Zhou, Hui Yu, Shuai-Wen Teng, Qi Guo, Zheyu Chen, Yue Wang
The metabolism of glucose is a nearly exclusive source of energy for maintaining neuronal survival, synaptic transmission and information processing in the brain. Two glucose metabolism pathways have been reported, direct neuronal glucose uptake and the astrocyte-neuron lactate shuttle (ANLS), which can be involved in these functions simultaneously or separately. Although ANLS in the dorsal hippocampus (DH) has been proved to be required for memory consolidation, the specific metabolic pathway involved during memory acquisition remains unclear...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29205377/adenosine-a2a-receptors-are-required-for-glutamate-mglur5-and-dopamine-d1-receptor-evoked-erk1-2-phosphorylation-in-rat-hippocampus-involvement-of-nmda-receptor
#4
Paraskevi Krania, Eleni Dimou, Maria Bantouna, Stylianos Kouvaros, Eirini Tsiamaki, Costas Papatheodoropoulos, Konstantinos Sarantis, Fevronia Angelatou
Interaction between mGluR5 and NMDA receptors (NMDAR) is vital for synaptic plasticity and cognition. We recently demonstrated that stimulation of mGluR5 enhances NMDAR-responses in hippocampus by phosphorylating NR2B(Tyr1472) subunit, and this reaction was enabled by adenosine A2A receptors(A2A R) (Sarantis et al.2015). In this study, by using in vitro phosphorylation and western blot analysis in hippocampal slices of male Wistar rats, we show, that mGluR5 stimulation or mGluR5/NMDARs co-stimulation, synergistically activate ERK1/2 signaling leading to c-Fos expression...
December 5, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29204864/erp-evidence-for-temporal-independence-of-set-size-and-object-updating-in-object-substitution-masking
#5
Christine M Salahub, Stephen M Emrich
To keep track of dynamically changing objects in one's environment, it is necessary to individuate them from other objects, both temporally and spatially. Spatially, objects can be selected from nearby distractors using selective attention. Temporally, object updating processes incorporate new information into existing representations over time. Both of these processes have been implicated in a type of visual masking called object-substitution masking (OSM). Previous studies have found that the number of distractors (impacting selective attention) interacts with the strength of OSM...
December 4, 2017: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/29204119/differential-effects-of-inactivation-of-discrete-regions-of-medial-prefrontal-cortex-on-memory-consolidation-of-moderate-and-intense-inhibitory-avoidance-training
#6
María E Torres-García, Andrea C Medina, Gina L Quirarte, Roberto A Prado-Alcalá
It has been found that the medial prefrontal cortex (mPFC) is involved in memory encoding of aversive events, such as inhibitory avoidance (IA) training. Dissociable roles have been described for different mPFC subregions regarding various memory processes, wherein the anterior cingulate cortex (ACC), prelimbic cortex (PL), and infralimbic cortex (IL) are involved in acquisition, retrieval, and extinction of aversive events, respectively. On the other hand, it has been demonstrated that intense training impedes the effects on memory of treatments that typically interfere with memory consolidation...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29203303/interactive-effects-of-morphine-and-nicotine-on-memory-function-depend-on-the-central-amygdala-cannabinoid-cb1-receptor-function-in-rats
#7
Fatemeh Tirgar, Ameneh Rezayof, Sakineh Alijanpour, Nima Yazdanbakhsh
The present study investigated the possible involvement of the central amygdala (CeA) cannabinoid receptors type-1 (CB1Rs) in the interactive effects of morphine and nicotine on memory formation in a passive avoidance learning task. Our results showed that systemic administration of morphine (3 and 6mg/kg, s.c.) immediately after training phase impaired memory consolidation and induced amnesia. Administration of nicotine (0.3 and 0.6mg/kg, s.c.) before testing phase significantly restored morphine-induced amnesia, suggesting a cross state-dependent learning between morphine and nicotine...
December 1, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29203208/systems-consolidation-revisited-but-not-revised-the-promise-and-limits-of-optogenetics-in-the-study-of-memory
#8
REVIEW
Hardt Oliver, Nadel Lynn
Episodic memories (in humans) and event-like memories (in non-human animals) require the hippocampus for some time after acquisition, but at remote points seem to depend more on cortical areas instead. Systems consolidation refers to the process that promotes this reorganization of memory. Various theoretical frameworks accounting for this process have been proposed, but clear evidence favoring one or another of these positions has been lacking. Addressing this issue, a recent study deployed some of the most advanced neurobiological technologies - optogenetics and calcium imaging - and provided high resolution, precise observations regarding brain systems involved in recent and remote contextual fear memories...
December 1, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29198599/who-is-the-boss-individual-recognition-memory-and-social-hierarchy-formation-in-crayfish
#9
Nayeli Jiménez-Morales, Karina Mendoza-Ángeles, Mercedes Porras-Villalobos, Elizabeth Ibarra-Coronado, Gabriel Roldán-Roldán, Jesús Hernández-Falcón
Under laboratory conditions, crayfish establish hierarchical orders through agonistic encounters whose outcome defines the dominant one and one, or more, submissive animals. These agonistic encounters are ritualistic, based on threats, pushes, attacks, grabs, and avoidance behaviors that include retreats and escape responses. Agonistic behavior in a triad of unfamiliar, size-matched animals is intense on the first day of social interaction and the intensity fades on daily repetitions. The dominant animal keeps its status for long periods, and the submissive ones seem to remember 'who the boss is'...
November 30, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29191578/gastrin-releasing-peptide-attenuates-fear-memory-reconsolidation
#10
A Murkar, P Kent, C Cayer, J James, Z Merali
BACKGROUND: Gastrin Releasing Peptide (GRP) may play a role in fear learning. The GRP Receptor is expressed in the basolateral amygdala and hippocampus, and central administration of GRP mediates fear learning. The effects of GRP on reconsolidation, however, have been minimally explored. Reconsolidation, the process by which formed memories are rendered labile following recall, provides a window of opportunity for pharmacological intervention. Although evidence suggests the window of opportunity to alter reactivated consolidation memory can be as long as 6h, shorter intervals have not been extensively investigated...
November 27, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29189024/extension-to-one-week-of-verbal-memory-consolidation-assessment
#11
Romina Manoli, Laurence Chartaux-Danjou, Halima Mecheri, Hélène Delecroix, Marion Noulhiane, Christine Moroni
OBJECTIVE: Although impairments of long-term recall affect everyday life, they may be missed by standard delayed recall tests, which typically assess the ability to retain new information within a few minutes, without encompassing the consolidation process. We adapted a verbal memory test to evaluate long-term memory consolidation in healthy volunteers. METHOD: A sample of 238 participants (M = 42.23 years old, SD = 16.45) was administered an adapted version of the French RL/RI-16 (Van der Linden & the members of GREMEM, 2004), the One-Week Free and Cued Selective Reminding Test-word version, in which special feature relies on a 30-min and a 1-week-delayed recall after encoding...
November 30, 2017: Neuropsychology
https://www.readbyqxmd.com/read/29187752/inhibiting-rho-kinase-promotes-goal-directed-decision-making-and-blocks-habitual-responding-for-cocaine
#12
Andrew M Swanson, Lauren M DePoy, Shannon L Gourley
The prelimbic prefrontal cortex is necessary for associating actions with their consequences, enabling goal-directed decision making. We find that the strength of action-outcome conditioning correlates with dendritic spine density in prelimbic cortex, suggesting that new action-outcome learning involves dendritic spine plasticity. To test this, we inhibited the cytoskeletal regulatory factor Rho kinase. We find that the inhibitor fasudil enhances action-outcome memory, resulting in goal-directed behavior in mice that would otherwise express stimulus-response habits...
November 30, 2017: Nature Communications
https://www.readbyqxmd.com/read/29187611/enhancing-memory-consolidation-through-slow-oscillation-and-spindle-synchronization
#13
Sara Y Kim, Enmanuelle Pardilla-Delgado, Sara E Alger
No abstract text is available yet for this article.
November 29, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29187519/proteomics-reveals-the-molecular-underpinnings-of-stronger-learning-and-memory-in-eastern-compared-to-western-beess
#14
Lifeng Meng, Xinmei Huo, Mao Feng, Yu Fang, Bin Han, Han Hu, Fan Wu, Jianke Li
The eastern (Apis cerana cerana, Acc) and western (Apis mellifera ligustica, Aml) honeybee are two major honeybee species. Surprisingly, little is known about the fundamental molecular neurobiology of brain sub-organs of Acc and Aml. We characterized and compared the proteomes of mushroom bodies (MBs), antennal lobes (ALs) and optical lobes (OLs) in the brain of both species, and biologically validated the functions related to learning and memory. Acc and Aml have evolved similar proteome signatures in MBs and OLs to drive the domain-specific neural activities...
November 29, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29184500/camkii-requirement-for-in-vivo-insular-cortex-ltp-maintenance-and-cta-memory-persistence
#15
Yectivani Juárez-Muñoz, Laura E Ramos-Languren, Martha L Escobar
Calcium-calmodulin/dependent protein kinase II (CaMKII) plays an essential role in LTP induction, but since it has the capacity to remain persistently activated even after the decay of external stimuli it has been proposed that it can also be necessary for LTP maintenance and therefore for memory persistence. It has been shown that basolateral amygdaloid nucleus (Bla) stimulation induces long-term potentiation (LTP) in the insular cortex (IC), a neocortical region implicated in the acquisition and retention of conditioned taste aversion (CTA)...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29175514/reward-anticipation-modulates-the-effect-of-stress-related-increases-in-cortisol-on-episodic-memory
#16
Jörn A Quent, Andrew M McCullough, Matt Sazma, Oliver T Wolf, Andrew P Yonelinas
When acute stress is experienced shortly after an event is encoded into memory, this can slow the forgetting of the study event, which is thought to reflect the effect of cortisol on consolidation. In addition, when events are encoded under conditions of high reward they tend to be remembered better than those encoded under non-rewarding conditions, and these effects are thought to reflect the operation of the dopaminergic reward system. Although both modulatory systems are believed to impact the medial temporal lobe regions critical for episodic memory, the manner, and even the extent, to which these two systems interact is currently unknown...
November 21, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29174946/fluoxetine-not-donepezil-reverses-anhedonia-cognitive-dysfunctions-and-hippocampal-proteome-changes-during-repeated-social-defeat-exposure
#17
M G Gottschalk, P Mortas, M Haman, S Ozcan, B Biemans, S Bahn
While anhedonia is considered a core symptom of major depressive disorder (MDD), less attention has been paid to cognitive dysfunctions. We evaluated the behavioural and molecular effects of a selective serotonin re-uptake inhibitor (SSRI, fluoxetine) and an acetylcholinesterase inhibitor (AChEI, donepezil) on emotional-cognitive endophenotypes of depression and the hippocampal proteome. A chronic social defeat (SD) procedure was followed up by "reminder" sessions of direct and indirect SD. Anhedonia-related behaviour was assessed longitudinally by intracranial self-stimulation (ICSS)...
November 23, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29163309/eye-movement-desensitization-and-reprocessing-and-slow-wave-sleep-a-putative-mechanism-of-action
#18
Marco Pagani, Benedikt L Amann, Ramon Landin-Romero, Sara Carletto
Eye Movement Desensitization and Reprocessing (EMDR) is considered highly efficacious for the treatment of Post-traumatic Stress Disorder and has proved to be a valid treatment approach with a wide range of applications. However, EMDR's mechanisms of action is not yet fully understood. This is an active area of clinical and neurophysiological research, and several different hypotheses have been proposed. This paper discusses a conjecture which focuses on the similarity between the delta waves recorded by electroencephalography during Slow Wave Sleep (SWS) and those registered upon typical EMDR bilateral stimulation (eye movements or alternate tapping) during recurrent distressing memories of an emotionally traumatic event...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29163063/acetylcholine-neuromodulation-in-normal-and-abnormal-learning-and-memory-vigilance-control-in-waking-sleep-autism-amnesia-and-alzheimer-s-disease
#19
Stephen Grossberg
Adaptive Resonance Theory, or ART, is a neural model that explains how normal and abnormal brains may learn to categorize and recognize objects and events in a changing world, and how these learned categories may be remembered for a long time. This article uses ART to propose and unify the explanation of diverse data about normal and abnormal modulation of learning and memory by acetylcholine (ACh). In ART, vigilance control determines whether learned categories will be general and abstract, or specific and concrete...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/29162813/chemogenomic-analysis-reveals-key-role-for-lysine-acetylation-in-regulating-arc-stability
#20
Jasmin Lalonde, Surya A Reis, Sudhir Sivakumaran, Carl S Holland, Hendrik Wesseling, John F Sauld, Begum Alural, Wen-Ning Zhao, Judith A Steen, Stephen J Haggarty
The role of Arc in synaptic plasticity and memory consolidation has been investigated for many years with recent evidence that defects in the expression or activity of this immediate-early gene may also contribute to the pathophysiology of brain disorders including schizophrenia and fragile X syndrome. These results bring forward the concept that reversing Arc abnormalities could provide an avenue to improve cognitive or neurological impairments in different disease contexts, but how to achieve this therapeutic objective has remained elusive...
November 21, 2017: Nature Communications
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