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Memory consolidation

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https://www.readbyqxmd.com/read/29682834/the-nature-of-delayed-dream-incorporation-dream-lag-effect-personally-significant-events-persist-but-not-major-daily-activities-or-concerns
#1
Jean-Baptiste Eichenlaub, Elaine van Rijn, Mairéad Phelan, Larnia Ryder, M Gareth Gaskell, Penelope A Lewis, Matthew P Walker, Mark Blagrove
Incorporation of details from waking life events into rapid eye movement (REM) sleep dreams has been found to be highest on the 2 nights after, and then 5-7 nights after, the event. These are termed, respectively, the day-residue and dream-lag effects. This study is the first to categorize types of waking life experiences and compare their incorporation into dreams across multiple successive nights. Thirty-eight participants completed a daily diary each evening and a dream diary each morning for 14 days. In the daily diary, three categories of experiences were reported: major daily activities (MDAs), personally significant events (PSEs) and major concerns (MCs)...
April 22, 2018: Journal of Sleep Research
https://www.readbyqxmd.com/read/29681873/an-attempt-at-matching-waking-events-into-dream-reports-by-independent-judges
#2
Jia Xi Wang, He Yong Shen
Correlations between memories and dreaming has typically been studied by linking conscious experiences and dream reports, which has illustrated that dreaming reflects waking life events, thoughts, and emotions. As some research suggests that sleep has a function of memory consolidation, and dreams reflect this, researching this relationship further may uncover more useful insights. However, most related research has been conducted using the self-report method which asks participants to judge the relationship between their own conscious experiences and dreams...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29680772/%C3%AE-adrenergic-signaling-is-required-for-the-induction-of-a-labile-state-during-memory-reconsolidation
#3
Chae-Seok Lim, Jae-Ick Kim, Chuljung Kwak, Jaehyun Lee, Eun Hae Jang, Jihae Oh, Bong-Kiun Kaang
Memory reconsolidation is the process by which previously consolidated memories reenter a labile state through reactivation of the memory trace and are actively consolidated through de novo protein synthesis. Although extensive studies have shown that β-adrenergic signaling plays a critical role in the restabilization of reactivated memory, its role in the destabilization of long-term memory is not well-studied. In this study, we found that membrane excitability increased in hippocampal CA1 neurons immediately after the retrieval of contextual fear memory...
April 19, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29680498/sleep-eeg-spectral-power-is-correlated-with-subjective-objective-discrepancy-of-sleep-onset-latency-in-major-depressive-disorder
#4
Seung-Gul Kang, Sara Mariani, Stephanie A Marvin, Kwang-Pil Ko, Susan Redline, John W Winkelman
We aimed to identify the sleep electroencephalography (EEG) spectral power correlates of the subjective-objective discrepancy (SOD) of sleep onset latency (SOL) in major depressive disorder (MDD), primary insomnia (PI), and normal sleeping control (NSC) groups. We examined relative power values in standard frequency bands of the EEG spectra during the first Non-Rapid Eye Movement (NREM) sleep period as correlates of SOD of SOL between sleep diary and polysomnography in MDD (n = 36), PI (n = 19), and NSC (n = 23) groups...
April 19, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29678758/identification-of-memory-reactivation-during-sleep-by-eeg-classification
#5
Suliman Belal, James Cousins, Wael El-Deredy, Laura Parkes, Jules Schneider, Hikaru Tsujimura, Alexia Zoumpoulaki, Marta Perapoch, Lorena Santamaria Covariabus, Penelope Lewis
Memory reactivation during sleep is critical for consolidation, but also extremely difficult to measure as it is subtle, distributed and temporally unpredictable. This article reports a novel method for detecting such reactivation in standard sleep recordings. During learning, participants produced a complex sequence of finger presses, with each finger cued by a distinct audio-visual stimulus. Auditory cues were then re-played during subsequent sleep to trigger neural reactivation through a method known as targeted memory reactivation (TMR)...
April 17, 2018: NeuroImage
https://www.readbyqxmd.com/read/29674952/stability-and-function-of-hippocampal-mossy-fiber-synapses-depend-on-bcl11b-ctip2
#6
Elodie De Bruyckere, Ruth Simon, Sigrun Nestel, Bernd Heimrich, Dennis Kätzel, Alexei V Egorov, Pentao Liu, Nancy A Jenkins, Neal G Copeland, Herbert Schwegler, Andreas Draguhn, Stefan Britsch
Structural and functional plasticity of synapses are critical neuronal mechanisms underlying learning and memory. While activity-dependent regulation of synaptic strength has been extensively studied, much less is known about the transcriptional control of synapse maintenance and plasticity. Hippocampal mossy fiber (MF) synapses connect dentate granule cells to CA3 pyramidal neurons and are important for spatial memory formation and consolidation. The transcription factor Bcl11b/Ctip2 is expressed in dentate granule cells and required for postnatal hippocampal development...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29673482/dunce-phosphodiesterase-acts-as-a-checkpoint-for-drosophila-long-term-memory-in-a-pair-of-serotonergic-neurons
#7
Lisa Scheunemann, Pierre-Yves Plaçais, Yann Dromard, Martin Schwärzel, Thomas Preat
A key function of the brain is to filter essential information and store it in the form of stable, long-term memory (LTM). We demonstrate here that the Dunce (Dnc) phosphodiesterase, an important enzyme that degrades cAMP, acts as a molecular switch that controls LTM formation in Drosophila. We show that, during LTM formation, Dnc is inhibited in the SPN, a pair of newly characterized serotonergic neurons, which stimulates the cAMP/PKA pathway. As a consequence, the SPN activates downstream dopaminergic neurons, opening the gate for LTM formation in the olfactory memory center, the mushroom body...
April 18, 2018: Neuron
https://www.readbyqxmd.com/read/29671052/is-it-possible-to-modify-fear-memories-in-humans-with-extinction-training-within-a-single-day
#8
Jaime Redondo, Jose Fernandez-Rey, Daniel Gonzalez-Gonzalez
Extinction procedures have been used widely in the study of fear memories, and different positions have been adopted regarding the efficacy of such procedures and the mechanisms involved. It has been argued that extinction may interfere with the consolidation of the fear memory if the procedure is applied with the appropriate timing after acquisition. However, the opposite position is also held, that is, that the extinction does not achieve an elimination of the fear response. The aim of the present study is to test the short-term effects of immediate extinction in fear reduction when this extinction is preceded by a retrieval trial...
April 18, 2018: Psychological Research
https://www.readbyqxmd.com/read/29669258/rapid-effects-on-memory-consolidation-and-spine-morphology-by-estradiol-in-female-and-male-rodents
#9
REVIEW
Victoria Luine, Peter Serrano, Maya Frankfurt
Rapid, neurosteroid-like effects of estrogens on memory consolidation during recognition memory tasks in both male and female rodents are described. We discuss how these mnemonic changes are related to rapid estrogenic effects on dendritic spine density, the distribution of spine types and the expression of PSD95 and GluA2 within spines in the hippocampus and medial prefrontal cortex, two areas critical for learning and memory. Overall, these data lead to the conclusion that estrogens are capable of exerting rapid and potent influences on memory and spine morphology in both sexes...
April 15, 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29668862/evidence-that-default-network-connectivity-during-rest-consolidates-social-information
#10
Meghan L Meyer, Lila Davachi, Kevin N Ochsner, Matthew D Lieberman
Brain regions engaged during social inference, medial prefrontal cortex (MPFC) and tempoparietal junction (TPJ), are also known to spontaneously engage during rest. While this overlap is well known, the social cognitive function of engaging these regions during rest remains unclear. Building on past research suggesting that new information is committed to memory during rest, we explored whether one function of MPFC and TPJ engagement during rest may be to consolidate new social information. MPFC and TPJ regions significantly increased connectivity during rest after encoding new social information (relative to baseline and post nonsocial encoding rest periods)...
April 13, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29661836/fear-memory-consolidation-in-sleep-requires-protein-kinase-a
#11
Jiyeon Cho, Krzysztof A Sypniewski, Shoko Arai, Kazuo Yamada, Sonoko Ogawa, Constantine Pavlides
It is well established that protein kinase A (PKA) is involved in hippocampal dependent memory consolidation. Sleep is also known to play an important role in this process. However, whether sleep-dependent memory consolidation involves PKA activation has not been clearly determined. Using behavioral observation, animals were categorized into sleep and awake groups. We show that intrahippocampal injections of the PKA inhibitor Rp-cAMPs in post-contextual fear conditioning sleep produced a suppression of long-term fear memory, while injections of Rp-cAMPs during an awake state, at a similar time point, had no effect...
May 2018: Learning & Memory
https://www.readbyqxmd.com/read/29661833/no-is-required-for-memory-formation-and-expression-of-memory-and-for-minor-behavioral-changes-during-training-with-inedible-food-in-aplysia
#12
Valeria Briskin-Luchinsky, Shlomit Tam, Shlomit Shabbat, Itay Hurwitz, Abraham J Susswein
A learning experience may lead to changes in behavior during the experience, and also to memory expressed at a later time. Are signals causing changes in behavior during the learning experience related to the formation and expression of memory? We examined this question, using learning that food is inedible in Aplysia Treatment of an isolated buccal ganglia preparation with an NO donor elicited rejection-like motor programs. Rejection initiated by NO production is consistent with aspects of behavioral changes seen while animals learn, and with memory formation...
May 2018: Learning & Memory
https://www.readbyqxmd.com/read/29661832/kinase-activity-in-the-olfactory-bulb-is-required-for-odor-memory-consolidation
#13
Michelle T Tong, Tae-Young P Kim, Thomas A Cleland
Long-term fear memory formation in the hippocampus and neocortex depends upon brain-derived neurotrophic factor (BDNF) signaling after acquisition. Incremental, appetitive odor discrimination learning is thought to depend substantially on the differentiation of adult-born neurons within the olfactory bulb (OB)-a process that is closely associated with BDNF signaling. We sought to elucidate the role of neurotrophin signaling within the OB on odor memory consolidation. Male mice were trained on odor-reward associative discriminations after bilateral infusion of the kinase inhibitor K252a, or vehicle control, into the OB...
May 2018: Learning & Memory
https://www.readbyqxmd.com/read/29660400/hippocampal-coupling-with-cortical-and-subcortical-structures-in-the-context-of-memory-consolidation
#14
Ivan Skelin, Scott Kilianski, Bruce L McNaughton
Memory consolidation is a gradual process through which episodic memories become incorporated into long-term 'semantic' representations. It likely involves reactivation of neural activity encoding the recent experience during non-REM sleep. A critical prerequisite for memory consolidation is precise coordination of reactivation events between the hippocampus and cortical/subcortical structures, facilitated by the coupling of local field potential (LFP) oscillations (slow oscillations, sleep spindles and sharp wave/ripples) between these structures...
April 13, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29659655/poor-encoding-and-weak-early-consolidation-underlie-memory-acquisition-deficits-in-multiple-sclerosis-retroactive-interference-processing-speed-or-working-memory
#15
Joshua Sandry, Mark Zuppichini, Jessica Rothberg, Zerbrina Valdespino-Hayden, John DeLuca
Objective: Learning and memory impairments are common in multiple sclerosis (MS) and may be related to difficulty acquiring (encoding or consolidating) new information. We evaluate the role of retroactive interference and investigate whether minimizing interference immediately following encoding (early during consolidation) will improve MS participants' ability to remember new verbal information. Additionally, we investigate processing speed differences between memory-impaired and unimpaired participants and present an exploratory analysis of how the dual-components of working memory (capacity vs...
April 5, 2018: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29656871/activation-of-g-%C3%AE-q-signaling-enhances-memory-consolidation-and-slows-cognitive-decline
#16
Rachel N Arey, Geneva M Stein, Rachel Kaletsky, Amanda Kauffman, Coleen T Murphy
Perhaps the most devastating decline with age is the loss of memory. Therefore, identifying mechanisms to restore memory function with age is critical. Using C. elegans associative learning and memory assays, we identified a gain-of-function Gαq signaling pathway mutant that forms a long-term (cAMP response element binding protein [CREB]-dependent) memory following one conditioned stimulus-unconditioned stimulus (CS-US) pairing, which usually requires seven CS-US pairings. Increased CREB activity in AIM interneurons reduces the threshold for memory consolidation through transcription of a set of previously identified "long-term memory" genes...
April 6, 2018: Neuron
https://www.readbyqxmd.com/read/29656024/protein-synthesis-in-the-basolateral-amygdala-complex-is-required-for-consolidation-of-a-first-order-fear-memory-but-not-for-consolidation-of-a-higher-order-fear-memory
#17
Dana M Leidl, Belinda P P Lay, Cassandra Chakouch, R Frederick Westbrook, Nathan M Holmes
The present series of experiments pursued our recent findings that consolidation of a second-order fear memory requires neuronal activity, but not de novo protein synthesis, in the basolateral amygdala complex (BLA). It used a modified second-order conditioning protocol in which rats were exposed to S1-shock pairings in stage 1 and pairings of the serial S2-S1 compound and shock in stage 2. Experiment 1 showed that responding (freezing) to S2 in this protocol is conditional on its compounding with S1 in stage 2 (Experiment 1), and therefore, the result of associative formation...
April 12, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29653257/%C3%AE-adrenergic-receptors-reduce-the-threshold-for-induction-and-stabilization-of-ltp-and-enhance-its-magnitude-via-multiple-mechanisms-in-the-ventral-but-not-the-dorsal-hippocampus
#18
Vassilios Papaleonidopoulos, Costas Papatheodoropoulos
The hippocampus is a functionally heterogeneous structure with the cognitive and emotional signal processing ascribed to the dorsal (DH) and the ventral hippocampus (VH) respectively. However, the underlying mechanisms are poorly understood. Noradrenaline is released in hippocampus during emotional arousal modulating synaptic plasticity and memory consolidation through activation of β adrenergic receptors (β-ARs). Using recordings of field excitatory postsynaptic potentials from the CA1 field of adult rat hippocampal slices we demonstrate that long-term potentiation (LTP) induced either by theta-burst stimulation (TBS) that mimics a physiological firing pattern of hippocampal neurons or by high-frequency stimulation is remarkably more sensitive to β-AR activation in VH than in DH...
April 10, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29652580/methods-for-assessment-of-memory-reactivation
#19
Shizhao Liu, Andres D Grosmark, Zhe Chen
It has been suggested that reactivation of previously acquired experiences or stored information in declarative memories in the hippocampus and neocortex contributes to memory consolidation and learning. Understanding memory consolidation depends crucially on the development of robust statistical methods for assessing memory reactivation. To date, several statistical methods have seen established for assessing memory reactivation based on bursts of ensemble neural spike activity during offline states. Using population-decoding methods, we propose a new statistical metric, the weighted distance correlation, to assess hippocampal memory reactivation (i...
April 13, 2018: Neural Computation
https://www.readbyqxmd.com/read/29649583/noradrenergic-%C3%AE-receptor-antagonism-in-the-basolateral-amygdala-impairs-reconsolidation-but-not-extinction-of-alcohol-self-administration-intra-bla-propranolol-impairs-reconsolidation-of-alcohol-self-administration
#20
Rose Chesworth, Laura H Corbit
A critical barrier to recovery from alcohol addiction is relapse propensity. Alcohol cues can trigger relapse, and pharmacologically facilitating processes such as extinction, which decreases cue associations, may help prevent relapse. The noradrenergic system mediates extinction learning for alcohol; however, the neural locus of this effect is unknown. This study sought to determine whether the basolateral amygdala (BLA), a region critical for fear extinction, also mediates extinction of alcohol seeking. Hooded Wistar rats (N = 12-15 per experiment) were implanted with bilateral cannula targeting the BLA and trained to lever press for 10% ethanol during auditory or visual cues...
April 9, 2018: Neurobiology of Learning and Memory
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