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Memory consolidation

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https://www.readbyqxmd.com/read/29453207/hippocampal-ripple-oscillations-and-inhibition-first-network-models-frequency-dynamics-and-response-to-gaba-modulators
#1
José R Donoso, Dietmar Schmitz, Nikolaus Maier, Richard Kempter
Hippocampal ripples are involved in memory consolidation, but the mechanisms underlying their generation remain unclear. Models relying on interneuron networks in the CA1 region disagree on the predominant source of excitation to interneurons: either 'direct', via the Schaffer collaterals that provide feedforward input from CA3 to CA1, or 'indirect', via the local pyramidal cells in CA1, which are embedded in a recurrent excitatory-inhibitory network. Here, we used physiologically constrained computational models of basket-cell networks to investigate how they respond to different conditions of transient, noisy excitation...
February 16, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29449457/the-activity-of-thalamic-nucleus-reuniens-is-critical-for-memory-retrieval-but-not-essential-for-the-early-phase-of-off-line-consolidation
#2
Hao Mei, Nikos K Logothetis, Oxana Eschenko
Spatial navigation depends on the hippocampal function, but also requires bidirectional interactions between the hippocampus (HPC) and the prefrontal cortex (PFC). The cross-regional communication is typically regulated by critical nodes of a distributed brain network. The thalamic nucleus reuniens (RE) is reciprocally connected to both HPC and PFC and may coordinate the information flow within the HPC-PFC pathway. Here we examined if RE activity contributes to the spatial memory consolidation. Rats were trained to find reward following a complex trajectory on a crossword-like maze...
March 2018: Learning & Memory
https://www.readbyqxmd.com/read/29449429/heterogeneous-origins-of-human-sleep-spindles-in-different-cortical-layers
#3
Donald J Hagler, Istvan Ulbert, Lucia Wittner, Lorand Erőss, Joseph R Madsen, Orrin Devinsky, Werner Doyle, Daniel Fabo, Sydney S Cash, Eric Halgren
Sleep spindles are a cardinal feature in human NREM sleep and may be important for memory consolidation. We studied the intracortical organization of spindles in men and women by recording spontaneous sleep spindles from different cortical layers using linear microelectrode arrays. Two patterns of spindle generation were identified using visual inspection, and confirmed with factor analysis. Spindles (10-16Hz) were largest and most common in upper and middle channels, with limited involvement of deep channels...
February 15, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29447857/estradiol-effect-on-short-term-object-memory-under-hypocholinergic-condition
#4
Luciana M Pereira, Isabella M Guimarães, Vinícius E M Oliveira, Cristiane P Bastos, Fabíola M Ribeiro, Vânia F Prado, Marco A M Prado, Grace S Pereira
Estrogens positively affect object recognition memory (ORM). However, whether this effect rely on acetylcholine is unknown. Here we investigated if 17β-estradiol (E2) would be able to recover ORM deficits in animals with decreased expression of the Vesicular Acetylcholine Transporter (VAChT KD HET ). We found that E2 improved short-term ORM (STM) in VAChT KD HET male and in OVX female mutant mice. However, E2 did not recover long-term (LTM) ORM in both sexes. Next, we tested whether hippocampal ERs activation could also rescue STM in mutant mice...
February 12, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29447217/does-napping-enhance-the-effects-of-cognitive-bias-modification-appraisal-training-an-experimental-study
#5
Marcella L Woud, Jan C Cwik, Simon E Blackwell, Birgit Kleim, Emily A Holmes, Dirk Adolph, Hui Zhang, Jürgen Margraf
Posttraumatic Stress Disorder (PTSD) is characterised by dysfunctional appraisals of the trauma and its consequences including one's own symptoms. Experimental studies have shown that Cognitive Bias Modification-Appraisal (CBM-App) training can reduce dysfunctional interpretations and analog trauma symptoms. One important question is how to enhance the effects of CBM-App. Following work suggesting that sleep has beneficial effects on consolidation processes and can thus improve learning, the present study investigated whether a brief period of sleep (i...
2018: PloS One
https://www.readbyqxmd.com/read/29445333/sleep-dependent-memory-consolidation-and-incremental-sentence-comprehension-computational-dependencies-during-language-learning-as-revealed-by-neuronal-oscillations
#6
Zachariah R Cross, Mark J Kohler, Matthias Schlesewsky, M G Gaskell, Ina Bornkessel-Schlesewsky
We hypothesize a beneficial influence of sleep on the consolidation of the combinatorial mechanisms underlying incremental sentence comprehension. These predictions are grounded in recent work examining the effect of sleep on the consolidation of linguistic information, which demonstrate that sleep-dependent neurophysiological activity consolidates the meaning of novel words and simple grammatical rules. However, the sleep-dependent consolidation of sentence-level combinatorics has not been studied to date...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29444449/dendritic-spine-density-and-ephrinb2-levels-of-hippocampal-and-anterior-cingulate-cortex-neurons-increase-sequentially-during-formation-of-recent-and-remote-fear-memory-in-the-mouse
#7
Georgia Abate, Sandra Colazingari, Alessandra Accoto, David Conversi, Arturo Bevilacqua
Memory consolidation is a dynamic process that involves a sequential remodeling of hippocampal-cortical circuits. Although synaptic events underlying memory consolidation are well assessed, fine molecular events controlling this process deserve further characterization. To this aim, we challenged male C57BL/6N mice in a contextual fear conditioning (CFC) paradigm and tested their memory 24 h, 7 days or 36 days later. Mice displayed a strong fear response at all time points with an increase in dendritic spine density and protein levels of the cell adhesion factor EphrinB2 in CA1 hippocampal neurons 24 h and 7 days post conditioning (p...
February 11, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29441005/atypical-within-session-motor-procedural-learning-after-traumatic-brain-injury-but-well-preserved-between-session-procedural-memory-consolidation
#8
Maria Korman, Sharon Shaklai, Keren Cisamariu, Carmit Gal, Rinatia Maaravi-Hesseg, Ishay Levy, Ofer Keren, Avi Karni, Yaron Sacher
Using the finger-to-thumb opposition sequence (FOS) learning task, we characterized motor skill learning in sub-acute patients hospitalized for rehabilitation following traumatic brain injury (TBI). Ten patients (Trained TBI) and 11 healthy participants (Trained Healthy) were trained using a multi-session protocol: a single session was afforded in the first week of the study, and four daily sessions were afforded during the second week. Intensity of practice was adapted to patients. Performance speed and accuracy were tested before and after each session...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29440996/is-there-a-canonical-cortical-circuit-for-the-cholinergic-system-anatomical-differences-across-common-model-systems
#9
REVIEW
Jennifer J Coppola, Anita A Disney
Acetylcholine (ACh) is believed to act as a neuromodulator in cortical circuits that support cognition, specifically in processes including learning, memory consolidation, vigilance, arousal and attention. The cholinergic modulation of cortical processes is studied in many model systems including rodents, cats and primates. Further, these studies are performed in cortical areas ranging from the primary visual cortex to the prefrontal cortex and using diverse methodologies. The results of these studies have been combined into singular models of function-a practice based on an implicit assumption that the various model systems are equivalent and interchangeable...
2018: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/29438740/adult-hippocampal-mecp2-preserves-the-genomic-responsiveness-to-learning-required-for-long-term-memory-formation
#10
Kubra Gulmez Karaca, David V C Brito, Benjamin Zeuch, Ana M M Oliveira
MeCP2 is required both during postnatal neurodevelopment and throughout the adult life for brain function. Although it is well accepted that MeCP2 in the maturing nervous system is critical for establishing normal development, the functions of MeCP2 during adulthood are poorly understood. Particularly, the requirement of hippocampal MeCP2 for cognitive abilities in the adult is not studied. To characterize the role of MeCP2 in adult neuronal function and cognition, we used a temporal and region-specific disruption of MeCP2 expression in the hippocampus of adult male mice...
February 10, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29434376/memory-formation-depends-on-both-synapse-specific-modifications-of-synaptic-strength-and-cell-specific-increases-in-excitability
#11
REVIEW
John Lisman, Katherine Cooper, Megha Sehgal, Alcino J Silva
The modification of synaptic strength produced by long-term potentiation (LTP) is widely thought to underlie memory storage. Indeed, given that hippocampal pyramidal neurons have >10,000 independently modifiable synapses, the potential for information storage by synaptic modification is enormous. However, recent work suggests that CREB-mediated global changes in neuronal excitability also play a critical role in memory formation. Because these global changes have a modest capacity for information storage compared with that of synaptic plasticity, their importance for memory function has been unclear...
February 12, 2018: Nature Neuroscience
https://www.readbyqxmd.com/read/29433734/foxo-in-neural-cells-and-diseases-of-the-nervous-system
#12
Evan E Santo, Jihye Paik
The evolutionarily conserved FOXO family of transcription factors has emerged as a significant arbiter of neural cell fate and function in mammals. From the neural stem cell (NSC) state through mature neurons under both physiological and pathological conditions, they have been found to modulate neural cell survival, stress responses, lineage commitment, and neuronal signaling. Lineage-specific FOXO knockout mice have provided an invaluable tool for the dissection of FOXO biology in the nervous system. Within the NSC compartments of the brain, FOXOs are required for the maintenance of NSC quiescence and for the clearance of reactive oxygen species...
2018: Current Topics in Developmental Biology
https://www.readbyqxmd.com/read/29432778/-looking-at-nothing-during-sequential-sensorimotor-actions-long-term-memory-based-eye-scanning-of-remembered-target-locations
#13
Rebecca M Foerster
Before acting humans saccade to a target object to extract relevant visual information. Even when acting on remembered objects, locations previously occupied by relevant objects are fixated during imagery and memory tasks - a phenomenon called "looking-at-nothing". While looking-at-nothing was robustly found in tasks encouraging declarative memory built-up, results are mixed in the case of procedural sensorimotor tasks. Eye-guidance to manual targets in complete darkness was observed in a task practiced for days beforehand, while investigations using only a single session did not find fixations to remembered action targets...
February 9, 2018: Vision Research
https://www.readbyqxmd.com/read/29431646/basolateral-amygdala-inputs-to-the-medial-entorhinal-cortex-selectively-modulate-the-consolidation-of-spatial-and-contextual-learning
#14
Krista L Wahlstrom, Mary L Huff, Eric B Emmons, John H Freeman, Nandakumar S Narayanan, Christa K McIntyre, Ryan T LaLumiere
Although evidence suggests that the basolateral amygdala (BLA) and dorsal hippocampus (DH) work together to influence the consolidation of spatial/contextual learning, the circuit mechanism by which the BLA selectively modulates spatial/contextual memory consolidation is not clear. The medial entorhinal cortex (mEC) is a critical region in the hippocampus-based system for processing spatial information. As an efferent target of the BLA, the mEC is a candidate by which the BLA influences the consolidation of such learning...
February 5, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29431457/is-memory-better-for-objects-than-for-separate-single-features-the-temporal-hypothesis
#15
Naomi Langerock, Evie Vergauwe, Nicolas Dirix, Pierre Barrouillet
Working memory, the system allowing for a simultaneous maintenance and processing of information, is typically conceived as a capacity limited system. A proposed method to transcend its standard maintenance capacity is to maintain multifeature objects, instead of isolated features. Several studies have shown that multifeature memory items are stored as objects instead of separate single features in working memory, this object-based maintenance being thought to result in an increase in the number of features that can be maintained...
February 12, 2018: Journal of Experimental Psychology. Learning, Memory, and Cognition
https://www.readbyqxmd.com/read/29425369/auditory-stimulation-of-sleep-slow-oscillations-modulates-subsequent-memory-encoding-through-altered-hippocampal-function
#16
Ju Lynn Ong, Amiya Patanaik, Nicholas I Y N Chee, Xuan Kai Lee, Jia-Hou Poh, Michael W L Chee
Study Objectives: Slow oscillations (SO) during sleep contribute to the consolidation of learned material. How the encoding of declarative memories during subsequent wakefulness might benefit from their enhancement during sleep is less clear. In this study, we aimed to investigate the impact of acoustically enhanced SO during a nap on subsequent encoding of declarative material. Methods: Thirty-seven healthy young adults were studied under two conditions: stimulation (STIM) and no stimulation (SHAM), in counter-balanced order following a night of sleep restriction (4h time-in-bed; TIB)...
February 7, 2018: Sleep
https://www.readbyqxmd.com/read/29423839/molecular-neuronal-and-behavioral-effects-of-ethanol-and-nicotine-interactions
#17
Paul M Klenowski, Andrew R Tapper
Ethanol and nicotine can modulate the activity of several neurotransmitter systems and signalling pathways. Interactions between ethanol and nicotine can also occur via common molecular targets including nicotinic acetylcholine receptors (nAChRs). These effects can induce molecular and synaptic adaptations that over time, are consolidated in brain circuits that reinforce drug-seeking behavior, contribute to the development of withdrawal symptoms during abstinence and increase the susceptibility to relapse. This chapter will discuss the acute and chronic effects of ethanol and nicotine within the mesolimbic reward pathway and brain circuits involved in learning, memory, and withdrawal...
February 9, 2018: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/29422138/roles-of-the-anterior-basolateral-amygdalar-nucleus-during-exposure-to-a-live-predator-and-to-a-predator-associated-context
#18
Ricardo Passoni Bindi, Marcus Vinicius C Baldo, Newton Sabino Canteras
The basolateral amygdala complex, which includes the lateral, basolateral and basomedial nuclei, has been implicated in innate and contextual fear responses to predator threats. In the basolateral complex, the lateral and posterior basomedial nuclei are able to process predator odor information, and they project to the predator-responsive hypothalamic circuit; lesions in these amygdalar sites reduce innate responses and practically abolish contextual fear responses to predatory threats. In contrast to the lateral and posterior basomedial nuclei, the basolateral nucleus does not receive direct information from predator olfactory cues and has no direct link to the predator-responsive hypothalamic circuit...
April 16, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29416508/the-default-mode-network-supports-episodic-memory-in-cognitively-unimpaired-elderly-individuals-different-contributions-to-immediate-recall-and-delayed-recall
#19
Lijuan Huo, Rui Li, Pengyun Wang, Zhiwei Zheng, Juan Li
While the neural correlates of age-related decline in episodic memory have been the subject of much interest, the spontaneous functional architecture of the brain for various memory processes in elderly adults, such as immediate recall (IR) and delayed recall (DR), remains unclear. The present study thus examined the neural correlates of age-related decline of various memory processes. A total of 66 cognitively normal older adults (aged 60-80 years) participated in this study. Memory processes were measured using the Auditory Verbal Learning Test as well as resting-state brain images, which were analyzed using both regional homogeneity (ReHo) and correlation-based functional connectivity (FC) approaches...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29412170/propranolol-disrupts-consolidation-of-emotional-memory-in-lymnaea
#20
Tamila Shymansky, Emily Hughes, Cailin M Rothwell, Ken Lukowiak
The therapeutic efficacy of the synthetic β-adrenergic receptor blocker, propranolol, for the treatment of post-traumatic stress disorder (PTSD) is currently being debated. Mixed results have been published regarding propranolol's ability to disrupt the consolidation and reconsolidation of memories. Here, we use the invertebrate model Lymnaea to study propranolol's ability to disrupt consolidation of memories formed under varying various types of stress which cause differing degrees of emotional memory. We show that when propranolol is administered immediately following operant conditioning, only the consolidation process of memories enhanced by individual stressors (i...
February 3, 2018: Neurobiology of Learning and Memory
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