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https://www.readbyqxmd.com/read/28926961/effects-of-metal-ions-temperature-and-a-denaturant-on-the-oxidative-folding-pathways-of-bovine-%C3%AE-lactalbumin
#1
Reina Shinozaki, Michio Iwaoka
Bovine α-lactalbumin (αLA) has four disulfide (SS) bonds in the native form (N). On the oxidative folding pathways of this protein, two specific SS folding intermediates, i.e., (61-77, 73-91) and des[6-120], which have two and three native SS bonds, respectively, accumulate predominantly in the presence of Ca(2+). In this study, we reinvestigated the pathways using a water-soluble cyclic selenoxide reagent, trans-3,4-dihydroxyselenolane oxide (DHS(ox)), as a strong and quantitative oxidant to oxidize the fully reduced form (R)...
September 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28926927/grim-19-represses-the-proliferation-and-invasion-of-cutaneous-squamous-cell-carcinoma-cells-associated-with-downregulation-of-stat3-signaling
#2
Na Wu, Haiying Hui, Li Cui, Fan Yang
The gene associated with retinoid-interferon-induced mortality-19 (GRIM-19) has been identified as a tumor suppressor in many human cancers. However, little is known about the role of GRIM-19 in cutaneous squamous cell carcinoma (CSCC). Here, we aimed to investigate the potential function of GRIM-19 in CSCC and explore the underlying molecular mechanisms. We found that GRIM-19 protein and transcript levels were significantly decreased in CSCC cell lines. Overexpression of GRIM-19 suppressed the proliferation and invasion of CSCC cells, whereas knockdown of GRIM-19 promoted the proliferation and invasion of CSCC cells...
September 15, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28926918/effects-of-graphene-oxide-on-the-performance-microbial-community-dynamics-and-antibiotic-resistance-genes-reduction-during-anaerobic-digestion-of-swine-manure
#3
Junya Zhang, Ziyue Wang, Yawei Wang, Hui Zhong, Qianwen Sui, Changping Zhang, Yuansong Wei
The role of graphene oxide (GO) on anaerobic digestion (AD) of swine manure concerning the performance, microbial community and antibiotic resistance genes (ARGs) reduction was investigated. Results showed that methane production was reduced by 13.1%, 10.6%, 2.7% and 17.1% at GO concentration of 5mg/L, 50mg/L, 100mg/L and 500mg/L, respectively, but propionate degradation was enhanced along with GO addition. Both bacterial and archaeal community changed little after GO addition. AD could well reduce ARGs abundance, but it was deteriorated at the GO concentration of 50mg/L and 100mg/L and enhanced at 500mg/L, while no obvious changes at 5mg/L...
September 4, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28926852/endoscopic-management-of-chronic-pancreatitis-with-a-fully-covered-self-expanding-metal-stent-and-laser-lithotripsy
#4
Aleksey Novikov, Ming-Ming Xu, Amy Tyberg, Michel Kahaleh
No abstract text is available yet for this article.
September 19, 2017: Endoscopy
https://www.readbyqxmd.com/read/28926806/simultaneous-removal-of-sulfides-and-benzene-in-fcc-gasoline-by-in-situ-hydrogenation-over-nilain-zro2-r-al2o3
#5
Lei Wang, Qian Liu, Chunyu Jing, Jiajia Yin, Nchare Mominou, Shuzhen Li
The ZrO2-r-Al2O3 composite was developed and co-modified with nickel, lanthanum and indium species by the impregnation method. A fixed-bed reactor was utilized to investigate the activity of the resulting catalysts in the removal of sulfides and benzene in fluid catalytic cracking gasoline. The resultant samples were characterized using XRD, TEM, XPS, TGA, H2-TPR, NH3-TPD and N2 adsorption/desorption techniques. XRD analysis indicated no agglomeration of Ni and La species, in good agreement with the TEM image...
September 6, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28926756/warfarin-inhibits-allosterically-the-reductive-nitrosylation-of-ferric-human-serum-heme-albumin
#6
Paolo Ascenzi, Alessio Bocedi, Magda Gioia, Gabriella Fanali, Mauro Fasano, Massimo Coletta
Human serum heme-albumin (HSA-heme-Fe) displays heme-based ligand binding and (pseudo-)enzymatic properties. Here, the effect of the prototypical drug warfarin on kinetics and thermodynamics of NO binding to ferric and ferrous HSA-heme-Fe (HSA-heme-Fe(III) and HSA-heme-Fe(II), respectively) and on the NO-mediated reductive nitrosylation of the heme-Fe atom is reported; data were obtained between pH5.5 and 9.5 at 20.0°C. Since warfarin is a common drug, its effect on the reactivity of HSA-heme-Fe represents a relevant issue in the pharmacological therapy management...
September 5, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28926715/optical-forging-of-graphene-into-three-dimensional-shapes
#7
Andreas Johansson, Pasi Myllyperkiö, Pekka Koskinen, Jukka Aumanen, Juha Tapio Koivistoinen, Hung-Chieh Tsai, Chia-Hao Chen, Lo-Yueh Chang, Vesa-Matti Hiltunen, Jyrki Manninen, Wei-Yen Woon, Mika Pettersson
Atomically thin materials, such as graphene, are the ultimate building blocks for nanoscale devices. But although their synthesis and handling today are routine, all efforts thus far have been restricted to flat natural geometries, since the means to control their three-dimensional (3D) morphology has remained elusive. Here we show that, just as a blacksmith uses a hammer to forge a metal sheet into 3D shapes, a pulsed laser beam can forge graphene sheet into controlled 3D shapes in the nanoscale. The forging mechanism is based on laser-induced local expansion of graphene, as confirmed by computer simulations using thin sheet elasticity theory...
September 19, 2017: Nano Letters
https://www.readbyqxmd.com/read/28926707/medieval-gilding-technology-of-historical-metal-threads-revealed-by-electron-optical-and-micro-raman-spectroscopic-study-of-focused-ion-beam-milled-cross-sections
#8
Tamás Gábor Weiszburg, Katalin Gherdán, Kitti Ratter, Norbert Zajzon, Zsolt Bendő, György Z Radnoczi, Ágnes Takács, Tamás Váczi, Gábor Varga, György Szakmány
Although gilt silver threads were widely used for decorating historical textiles, their manufacturing techniques have been elusive for centuries. Contemporary written sources give only limited, sometimes ambiguous information, and detailed cross-sectional study of the microscale soft noble metal objects has been hindered by sample preparation. In this work, to give a thorough characterization of historical gilt silver threads, nano- and microscale textural, chemical and structural data on cross sections, prepared by focused ion beam milling, were collected, using various electron-optical methods (high-resolution scanning electron microscopy (SEM), wavelength-dispersive electron probe microanalysis (EPMA), electron back-scattered diffraction (EBSD) combined with energy-dispersive electron probe microanalysis (EDX), transmission electron microscopy (TEM) combined with EDX, and micro-Raman spectroscopy...
September 19, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28926705/a-low-temperature-transition-metal-free-cross-dehydrogenative-coupling-protocol-for-the-synthesis-of-3-3-disubstituted-oxindoles
#9
James R Donald, Richard John Kenneth Taylor, Wade F Petersen
A new low-temperature procedure for the synthesis of 3,3-disubstituted 2-oxindoles via cross dehydrogenative coupling (CDC) is reported. The use of a strong, non-reversible base in these reactions has been found to effect a dramatic drop in reaction temperature (to room temperature) relative to the current state-of-the-art (>100 °C). When employing iodine as an 'oxidant', new evidence suggests that this transformation may occur via a transiently stable iodinated intermediate rather than by direct single-electron oxidation...
September 19, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28926691/cobalt-porphyrin-thiazyl-radical-coordination-polymers-towards-metal-organic-electronics
#10
Delia A Haynes, Laura J van Laeren, Orde Q Munro
Herein we delineate an unusual one-dimensional coordination polymer (CP), 3, prepared from S = ½ Co(TPP), 1, (TPP = 5,10,15,20-tetraphenylporphyrin dianion) and S = ½ 4-(4'-pyridyl)-1,2,3,5-dithiadiazolyl (py-DTDA) radical, 2. The atypically long S-S distance for CP 3 (2.12 Å) reflects fractional electron transfer from the formally Co(II) ion into the antibonding π-SOMO of the metal-bound py-DTDA bridging ligand. The bonding in solid CP 3 involves non-integer redox states in a resonance hybrid repeat unit best formulated as [Co(TPP)](0...
September 19, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28926685/nir-absorbing-metal-free-organic-porphyrin-and-phthalocyanine-dyes-for-panchromatic-dscs
#11
Phillip Brogdon, Hammad Cheema, Jared Heath Delcamp
Dye-sensitized solar cells (DSCs) are a promising source of renewable energy. However, power conversion efficiency (PCE) of devices has been limited largely by the difficulty of producing electricity using photons from the near-infrared (NIR) spectral region. Metal-free organic sensitizers frequently employ strong electron donating or withdrawing moieties to tune the optical band gap to allow the absorption of lower energy wavelengths in charge transfer systems while porphyrins and phthalocyanines use substituents to shift the Soret and Q bands toward lower energy absorption...
September 19, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28926584/transcriptome-analysis-reveals-molecular-anthelmintic-effects-of-procyanidins-in-c-elegans
#12
Verena Spiegler, Andreas Hensel, Jochen Seggewiß, Milena Lubisch, Eva Liebau
Worldwide, more than 1 billion people are affected by infestations with soil-transmitted helminths and also in veterinary medicine helminthiases are a severe threat to livestock due to emerging resistances against the common anthelmintics. Proanthocyanidins have been increasingly investigated for their anthelmintic properties, however, except for an interaction with certain proteins of the nematodes, not much is known about their mode of action. To investigate the anthelmintic activity on a molecular level, a transcriptome analysis was performed in Caenorhabditis elegans after treatment with purified and fully characterized oligomeric procyanidins (OPC)...
2017: PloS One
https://www.readbyqxmd.com/read/28926475/altered-resting-state-functional-connectivity-of-default-mode-network-and-sensorimotor-network-in-heavy-metal-music-lovers
#13
Yan Sun, Congcong Zhang, Shuxia Duan, Xiaoxia Du, Vince D Calhoun
The aim of this study was to investigate the spontaneous neural activity and functional connectivity (FC) in heavy metal music lovers (HMML) compared with classical music lovers (CML) during resting state. Forty HMML and 31 CML underwent resting-state functional MRI scans. Fractional amplitude of low-frequency fluctuations (fALFF) and seed-based resting-state FC were computed to explore regional activity and functional integration. A voxel-based two-sample t-test was used to test the differences between the two groups...
September 18, 2017: Neuroreport
https://www.readbyqxmd.com/read/28926421/a-novel-hydroxyphenyl-hydrazone-derivate-ycl0426-inhibits-cancer-cell-proliferation-through-sequestering-iron
#14
Feifei Li, Long Long, Junhai Xiao, Chen Wang, Wei Li, Song Li, Changqi Zhao, Lili Wang
Cancer cells have an increased requirement for iron than normal cells, and iron chelators are under active consideration for cancer treatment. The metal-sequestering potential and antiproliferative mechanisms of a novel hydroxyphenyl hydrazone derivate YCL0426 were investigated here. Antiproliferative activity of YCL0426 was detected by MTT assay. The iron-sequestering potential was evaluated by ferrozine-Fe(II) sequestering assay and Fe(II) titration assay. Cell-cycle-arresting profile was checked by flow cytometry and the DNA synthesis status was evaluated by BrdU incorporation assay...
September 18, 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/28926395/is-metal-on-metal-total-hip-arthroplasty-still-an-alternative-commentary-on-an-article-by-tobias-reiner-md-et-al-mri-findings-in-patients-after-small-head-metal-on-metal-total-hip-arthroplasty-with-a-minimum-follow-up-of-10-years
#15
EDITORIAL
https://www.readbyqxmd.com/read/28926394/armd-and-presumed-dangerous-commentary-on-an-article-by-gulraj-s-matharu-bsc-hons-mrcs-mres-et-al-blood-metal-ion-thresholds-to-identify-patients-with-metal-on-metal-hip-implants-at-risk-of-adverse-reactions-to-metal-debris-an-external-multicenter-validation
#16
https://www.readbyqxmd.com/read/28926383/mri-findings-in-patients-after-small-head-metal-on-metal-total-hip-arthroplasty-with-a-minimum-follow-up-of-10-years
#17
Tobias Reiner, Thuy D Do, Matthias C Klot, Fabian Hertzsch, Kirsten Seelmann, Matthias M Gaida, Marc-André Weber, Tobias Gotterbarm
BACKGROUND: Concern has been raised about the late onset of adverse reactions to metal debris (ARMD) in patients with a small-head metal-on-metal total hip replacement. The aims of this study were to assess the frequency and characteristic appearance of ARMD in patients with a small-head (28-mm) metal-on-metal total hip replacement and elevated blood ion levels (>1 μg/L) after a minimum follow-up of 10 years and to analyze the possible risk factors associated with the prevalence of these lesions...
September 20, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28926382/blood-metal-ion-thresholds-to-identify-patients-with-metal-on-metal-hip-implants-at-risk-of-adverse-reactions-to-metal-debris-an-external-multicenter-validation-study-of-birmingham-hip-resurfacing-and-corail-pinnacle-implants
#18
Gulraj S Matharu, Fiona Berryman, Andrew Judge, Aleksi Reito, Jamie McConnell, Olli Lainiala, Stephen Young, Antti Eskelinen, Hemant G Pandit, David W Murray
BACKGROUND: The authors of recent studies have reported newly devised implant-specific blood metal ion thresholds to predict adverse reactions to metal debris (ARMD) in patients who have undergone unilateral or bilateral metal-on-metal (MoM) hip arthroplasty. These thresholds were most effective for identifying patients at low risk of ARMD. We investigated whether these newly devised blood metal ion thresholds could effectively identify patients at risk of ARMD after MoM hip arthroplasty in an external cohort of patients...
September 20, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28926266/metal-free-synthesis-of-unsymmetrical-organoselenides-and-selenoglycosides
#19
Yong Guan, Steven D Townsend
A one-pot, metal-free procedure has been developed to synthesize unsymmetrical organoselenides. In the first step of the reaction, arylation of potassium selenocyanate (KSeCN) with an iodonium reagent proceeds in the absence of a metal catalyst to produce an arylselenocyanate. In the second step, treatment with sodium borohydride unmasks a second selenium nucleophile that engages an aliphatic electrophile, iodonium reagent, or glycosyl halide. The procedure represents an umpolung approach to the synthesis of aryl-selenides...
September 19, 2017: Organic Letters
https://www.readbyqxmd.com/read/28926255/infrared-spectroscopic-and-theoretical-studies-on-the-omf2-and-omf-m-cr-mo-w-molecules-in-solid-argon
#20
Rui Wei, Qingnuan Li, Yu Gong, Lester Andrews, Zongtang Fang, Kanchana Sahan Thanthiriwatte, Monica Vasiliu, David A Dixon
Group 6 metal oxide fluoride molecules in the form of OMF2 and OMF (M=Cr, Mo, W) have been prepared via the reactions of laser-ablated metal atoms and OF2 in excess argon. Product identifications were carried out by using infrared spectroscopy, 18OF2 sample and electronic structure calculations. Reactions of group 6 metal atoms and OF2 resulted in the formation of ternary OCrF2, OMoF2 and OWF2 molecules with C2v symmetry in which the tetravalent metal center is coordinated by one oxygen and two fluorine atoms...
September 19, 2017: Journal of Physical Chemistry. A
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