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Pulmonary hypertension

I Papachatzakis, L Velentza, P Zarogoulidis, A Kallianos, G Trakada
OBJECTIVE: Chronic Obstructive Pulmonary Disease (COPD) and Obstructive Sleep Apnea (OSA) are separately associated with several comorbidities. The coexistence of the two diseases, referred to as overlap syndrome, may act as a predisposing factor for a higher prevalence of comorbidities compared to those associated with each disease separately. The objective of the study was to evaluate the relative prevalence of cardiovascular as well as other comorbidities, in patients with the overlap syndrome, as compared to patients that are diagnosed solely with OSA...
July 2018: European Review for Medical and Pharmacological Sciences
Laura González-Saiz, Alejandro Santos-Lozano, Carmen Fiuza-Luces, Paz Sanz-Ayán, Carlos A Quezada-Loaiza, Ana Ruiz-Casado, Lidia B Alejo, Angela Flox-Camacho, María Morán, Alejandro Lucia, Pilar Escribano-Subías
Background: Pulmonary hypertension (PH) leads to exercise capacity impairment, but limited data are available on the objective evaluation of physical activity (PA) levels in these patients. Methods: We assessed PA levels using triaxial accelerometry in Spanish PH patients (n=75, 48±14 years, 65% female) and gender/age matched controls (n=107), and examined potential associations of meeting minimum international recommendations [moderate-vigorous PA (MVPA) ≥150 min/week] with survival predictors...
June 2018: Annals of Translational Medicine
Young Bok Lee, Ji Hyun Lee, Min Ji Kang, Jin-Wou Kim, Dong Soo Yu, Kyung Do Han, Yong Gyu Park
The association between actinic keratosis (AK) and anthropometric measures has not been investigated. This study aims to evaluate the associations between anthropometric measures and the incidence of AK in South Korea. We analyzed clinical data from individuals aged over 20 years who received a health examination arranged by the national insurance program between 2005 and 2008. Newly diagnosed AK was identified using claims data from baseline to the date of diagnosis or until December 31, 2015. The incidence of AK was highest among the elderly (aged over 60 years) and showed a male bias...
July 18, 2018: Scientific Reports
Alberto M Marra, Robert Naeije, Francesco Ferrara, Olga Vriz, Anna Agnese Stanziola, Michele D'Alto, Antonello D'Andrea, Luca Carannante, Christina Alessandra Eichstaedt, Antonio Cittadini, Nicola Benjamin, Ekkehard Grünig, Eduardo Bossone
BACKGROUND: Tricuspid regurgitation velocity (TRV) is the most widely used parameter by transthoracic echocardiography (TTE) in the evaluation of patients with suspected pulmonary hypertension (PH). OBJECTIVES: To explore the physiologic range of TRV in healthy adults and to investigate its clinical determinants. METHODS: In the first part of the study, 614 healthy individuals (age 45.7± 14.7 years, 60.26% women) were prospectively assessed by TTE...
July 18, 2018: Respiration; International Review of Thoracic Diseases
Ryan G Short, Tina D Tailor
History A 31-year-old woman with a history of bilateral orthotopic lung transplantation performed 10 months earlier for cystic fibrosis presented for a routine follow-up appointment, with her chief symptom being a cough. The cough started approximately 1 month prior to this appointment and was minimally productive of clear to yellow phlegm. In addition to her cough, she reported increased sinus congestion and a sensation of "something in her upper chest." She denied shortness of breath, wheezing, hemoptysis, or cigarette smoking...
August 2018: Radiology
Bharathi D Jagadeesan, Kenneth K Liao, Ganesh Raveendran
Complex Coronary artery to Pulmonary artery fistulas (CPFs) can be difficult to manage with embolization or ligation. An 88-year-old woman with exertional angina was found to have a complex precordial CPF, severe Mitral regurgitation, and Pulmonary Hypertension. CPF treatment was recommended prior to minimally invasive mitral valve replacement (to avoid postoperative myocardial ischemia from worsened steal). The CPF was supplied by multiple branches from the LAD and RCA, and formed a complex common varicosity with multiple drainage channels to the pulmonary artery...
July 18, 2018: Catheterization and Cardiovascular Interventions
Deborah R Liptzin, Christopher D Baker, Jeffrey R Darst, Jason P Weinman, Megan K Dishop, Csaba Galambos, John T Brinton, Robin R Deterding
OBJECTIVES: We sought to describe the phenotype for patients with P.I.G. including presentation, evaluation, cardiac co-morbidities, high resolution computed tomography findings, and outcomes. METHODS: With institutional review board approval, we performed a retrospective review of patients with biopsy-proven P.I.G. Biopsies, high resolution chest computed tomography, and cardiac evaluations were reviewed and characterized by experts in each field. RESULTS: Sixty-two percent of the patients were male...
July 18, 2018: Pediatric Pulmonology
Timur Mese, Baris Guven, Murat Muhtar Yilmazer, Cem Karadeniz, Rahmi Ozdemir, Onder Doksoz
BACKGROUND: Mean platelet volume (MPV), platecrit, and platelet distribution width (PDW) are markers of platelet activation. Previous studies have found that platelet activation occurs in patients with pulmonary arterial hypertension. Platelet indices including MPV, PDW, and platecrit have not been studied in children with congenital heart disease associated pulmonary arterial hypertension (APAH-CHD) who survived and those who died. OBJECTIVE: The objective of this study to investigate the value of platelet indices with clinical and hemodynamic indicators predicting the disease severity and survival in children with APAH-CHD...
July 17, 2018: Congenital Heart Disease
Jeong-Moo Lee, Kwang-Woong Lee, Suk Kyun Hong, Kyung Chul Yoon, Jae-Hyung Cho, Nam-Joon Yi, Kyung-Suk Suh
BACKGROUND: Status in terms of major vascular structure invasion is a crucial factor for successful major hepatic resection. In particular, surgery for advanced tumors with inferior vena cava (IVC) invasion is difficult and may even be dangerous for the patient, having high risk of massive bleeding and greater chance of embolic complications such as stroke, bowel ischemia, and pulmonary venous thrombosis. For such reasons, many surgeons hesitate to carry out such surgical resection, and even if they do so, may not totally remove the tumor including the part inside the IVC, achieving R1 resection...
July 17, 2018: Annals of Surgical Oncology
Timothy Wen, Jason D Wright, Dena Goffman, Mary E D'Alton, William J Mack, Frank J Attenello, Alexander M Friedman
BACKGROUND: There is limited data on when postpartum readmissions for thromboembolism occur after delivery hospitalizations on a population basis in the United States. OBJECTIVE: To characterize risk factors for and timing of postpartum venous thromboembolism (VTE) readmission after delivery hospitalization discharge. STUDY DESIGN: The Healthcare Cost and Utilization Project's Nationwide Readmissions Database for calendar years 2013 and 2014 was used to perform a retrospective cohort study evaluating risk for readmission for venous thromboembolism within 60 days of discharge from a delivery hospitalization...
July 11, 2018: American Journal of Obstetrics and Gynecology
Szymon Darocha, Marta Banaszkiewicz, Arkadiusz Pietrasik, Michał Piłka, Michał Florczyk, Maria Wieteska, Anna Dobosiewicz, Sebastian Szmit, Adam Torbicki, Marcin Kurzyna
BACKGROUND: This study evaluated the incremental effect of riociguat on pulmonary hemodynamics in patients with inoperative or persistent chronic thromboembolic pulmonary hypertension (CTEPH) treated previously with sildenafil. METHODS: The retrospective study included 28 patients diagnosed with CTEPH who were ineligible for surgical treatment due to distal thrombi location or who suffered from persistent CTEPH after pulmonary endarterectomy and who were treated with sildenafil at a dose of 25 mg TID for a minimum of 3 months...
July 3, 2018: International Journal of Cardiology
Vinay Bahadur Panday, Ivandito Kuntjoro, Ting Ting Low, James W L Yip, Edgar Tay Lik Wui
No abstract text is available yet for this article.
July 16, 2018: QJM: Monthly Journal of the Association of Physicians
Paolo Versacci, Duccio Di Carlo, Maria C Digilio, Bruno Marino
PURPOSE OF REVIEW: In the last 40 years, with a better understanding of cardiac defects, and with the improved results of cardiac surgery, the life expectancy of persons with Down syndrome has significantly increased. This review article reports on advances in knowledge of cardiac defects and cardiovascular system of persons with trisomy 21. RECENT FINDINGS: New insights into the genetics of this syndrome have improved our understanding of the pathogenetic mechanisms of cardiac defects...
July 14, 2018: Current Opinion in Pediatrics
Jean Guglielminotti, Ruth Landau, Cynthia A Wong, Guohua Li
Background The incidence of severe maternal morbidity (SMM) during childbirth is increasing in the United States. A better characterization of risk factors for SMM may identify targets for improving maternal outcomes. This study aims to characterize patient-, hospital-, and neighborhood-level factors associated with SMM during childbirth. Methods SMM during childbirth was identified in the 2013-2014 State Inpatients Database for New York. Hospital and neighborhood characteristics were abstracted from the American Hospital Association and the Area Health Resources files...
July 16, 2018: Maternal and Child Health Journal
Marisol Herrera-Rivero, Rong Zhang, Stefanie Heilmann-Heimbach, Andreas Mueller, Soyhan Bagci, Till Dresbach, Lukas Schröder, Stefan Holdenrieder, Heiko M Reutter, Florian Kipfmueller
Pulmonary hypertension (PH) contributes to high mortality in congenital diaphragmatic hernia (CDH). A better understanding of the regulatory mechanisms underlying the pathology in CDH might allow the identification of prognostic biomarkers and potential therapeutic targets. We report the results from an expression profiling of circulating microRNAs (miRNAs) in direct post-pulmonary blood flow of 18 CDH newborns. Seven miRNAs differentially expressed in children that either died or developed chronic lung disease (CLD) up to 28 days after birth, compared to those who survived without developing CLD during this period, were identified...
July 16, 2018: Scientific Reports
Daniel X Augustine, Lindsay D Coates-Bradshaw, James Willis, Allan Harkness, Liam Ring, Julia Grapsa, Gerry Coghlan, Nikki Kaye, David Oxborough, Shaun Robinson, Julie Sandoval, Bushra S Rana, Anjana Siva, Petros Nihoyannopoulos, Luke S Howard, Kevin Fox, Sanjeev Bhattacharyya, Vishal Sharma, Richard P Steeds, Thomas Mathew
Pulmonary hypertension is defined as a mean arterial pressure of ≥25 mmHg as confirmed on right heart catheterisation. Traditionally, the pulmonary arterial systolic pressure has been estimated on echo by utilising the simplified Bernoulli equation from the peak tricuspid regurgitant velocity and adding this to an estimate of right atrial pressure. Previous studies have demonstrated a correlation between this estimate of pulmonary arterial systolic pressure and that obtained from invasive measurement across a cohort of patients...
September 2018: Echo Research and Practice
Sara Miranda, Alda Marques
OBJECTIVES: Chronic cardiovascular diseases, cancer, chronic respiratory diseases and diabetes are the four major groups of non-communicable diseases (NCDs) and the main cause of mortality worldwide. Pilates has been described as an effective intervention to promote healthy behaviors and physical activity in people with chronic diseases. However, the evidence of its effects in NCDs have not been systematized. We investigated the effects of Pilates in the four major groups of NCDs. DESIGN: A systematic review was performed...
August 2018: Complementary Therapies in Medicine
Ji-Ming Sha, Yi Cao, Sheng-Song Xu
Anomalous origin of the pulmonary artery from the ascending aorta (AOPA) can lead to congestive heart failure in infancy and with advancing age many patients will develop severe pulmonary hypertension. Surgical intervention had high mortality/morbidity risk if this happens. Strategies to manage these patients seem only limited to heart-lung transplantation or lung transplantation. Here, we successfully carried out surgical intervention to in an adult patient who had anomalous origin of the right pulmonary artery from the ascending aorta with high pressures in the ascending aorta and normally originating pulmonary artery...
July 13, 2018: Annals of Thoracic Surgery
Bodil Ivarsson, Roger Hesselstrand, Göran Rådegran, Barbro Kjellström
Pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) share similar quality of life impairment. The aim of the present study was to investigate health-related quality of life (HRQoL) and its relation to the perception of treatment and psychosocial support among PAH and CTEPH patients. All adult PAH or CTEPH patients in the Swedish Pulmonary Arterial Hypertension Register were invited to participate in a national cohort survey. The survey included the EuroQol 5-dimensions (EQ-5D) instrument that measures an individual's HRQoL; the Beliefs about Medicines Questionnaire-Specific Scale that assesses the perception of PAH-specific treatment; the Mastery scale that evaluates the feeling of control and ability to cope with the disease; and the Social Network and Support Scale that maps the social support network...
January 1, 2018: Chronic Respiratory Disease
Shuhei Miura, Yutaka Iba, Akira Yamada
No abstract text is available yet for this article.
August 1, 2018: European Journal of Cardio-thoracic Surgery
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