keyword
https://read.qxmd.com/read/38363249/source-of-hematopoietic-progenitor-cells-determines-their-capacity-to-generate-innate-lymphoid-cells-ex-vivo
#21
JOURNAL ARTICLE
Said Z Omar, Vera van Hoeven, Nienke J E Haverkate, Jolien M R Van der Meer, Carlijn Voermans, Bianca Blom, Mette D Hazenberg
BACKGROUND AIMS: The success of allogeneic hematopoietic cell transplantation (HCT) as therapy for hematologic conditions is negatively impacted by the occurrence of graft-versus-host disease (GVHD). Tissue damage, caused, for example, by chemotherapy and radiotherapy, is a key factor in GVHD pathogenesis. Innate lymphoid cells (ILCs) are important mediators of tissue repair and homeostasis. The presence of ILCs before, and enhanced ILC reconstitution after, allogeneic HCT is associated with a reduced risk to develop mucositis and GVHD...
February 14, 2024: Cytotherapy
https://read.qxmd.com/read/38359035/novel-approach-for-reconstruction-of-the-three-dimensional-biliary-system-in-decellularized-liver-scaffold-using-hepatocyte-progenitors
#22
JOURNAL ARTICLE
Kazuya Hirukawa, Hiroshi Yagi, Kohei Kuroda, Masafumi Watanabe, Kotaro Nishi, Shogo Nagata, Yuta Abe, Minoru Kitago, Shungo Adachi, Ryo Sudo, Yuko Kitagawa
Reconstruction of the biliary system is indispensable for the regeneration of transplantable liver grafts. Here, we report the establishment of the first continuous three-dimensional biliary system scaffold for bile acid excretion using a novel method. We confirmed the preservation of the liver-derived extracellular matrix distribution in the scaffold. In addition, hepatocyte progenitors decellularized via the bile duct by slow-speed perfusion differentiated into hepatocyte- and cholangiocyte-like cells, mimicking hepatic cords and bile ducts, respectively...
2024: PloS One
https://read.qxmd.com/read/38348657/molecular-and-spatial-signatures-of-mouse-embryonic-endothelial-cells-at-single-cell-resolution
#23
JOURNAL ARTICLE
Jian Chen, Xiaoran Zhang, Daniel Morris DeLaughter, Michael A Trembley, Shaila Saifee, Feng Xiao, Jiehui Chen, Pingzhu Zhou, Christine E Seidman, Jonathan G Seidman, William T Pu
BACKGROUND: Mature endothelial cells (ECs) are heterogeneous, with subtypes defined by tissue origin and position within the vascular bed (ie, artery, capillary, vein, and lymphatic). How this heterogeneity is established during the development of the vascular system, especially arteriovenous specification of ECs, remains incompletely characterized. METHODS: We used droplet-based single-cell RNA sequencing and multiplexed error-robust fluorescence in situ hybridization to define EC and EC progenitor subtypes from E9...
February 13, 2024: Circulation Research
https://read.qxmd.com/read/38342301/stromal-niche-signals-that-orchestrate-intestinal-regeneration
#24
REVIEW
Helen E Abud, Shanika L Amarasinghe, Diana Micati, Thierry Jardé
Stromal cell populations have a central role in providing signals that support the maintenance, differentiation and function of the intestinal epithelium. The behaviour and fate of epithelial cells is directed by the spatial organisation of stromal cells that either sustain stem and progenitor cell identity or drive differentiation. A combination of single-cell analyses, mouse models and organoid co-culture assays have provided insight into the diversity of signals delivered by stromal cells. Signalling gradients are established and fine-tuned by the expression of both signalling agonists and antagonists along the crypt-villus axis...
February 9, 2024: Cellular and Molecular Gastroenterology and Hepatology
https://read.qxmd.com/read/38342300/telocytes-in-the-luminal-gi-tract
#25
REVIEW
Michal Shoshkes-Carmel
Telocytes are unique mesenchymal cells characterized by multiple remarkably long cytoplasmic extensions that extend hundreds of micron away from the cell body. Through these extensions, telocytes establish a three-dimensional network by connecting with other telocytes and various cell types within the tissue. In the intestine, telocytes have emerged as an essential component of the stem cell niche, providing Wnt proteins that are critical for the proliferation of stem and progenitor cells. However, the analysis of single cell RNA sequencing has revealed other stromal populations and mechanisms for niche organization, raising questions about the role of telocytes as a component of the stem cell niche...
February 9, 2024: Cellular and Molecular Gastroenterology and Hepatology
https://read.qxmd.com/read/38342299/the-fibroblast-landscape-in-stomach-carcinogenesis
#26
REVIEW
Ela Contreras-Panta, Eunyoung Choi, James R Goldenring
Numerous recent studies using single cell RNA sequencing (scRNA-seq) and spatial transcriptomics have shown the vast cell heterogeneity, including epithelial, immune and stromal cells, present in the normal human stomach and at different stages of gastric carcinogenesis. Fibroblasts within the metaplastic and dysplastic mucosal stroma represent key contributors to the carcinogenic microenvironment in the stomach. The heterogeneity of fibroblast populations is present in the normal stomach, but plasticity within these populations underlies their alterations in association with both metaplasia and dysplasia...
February 9, 2024: Cellular and Molecular Gastroenterology and Hepatology
https://read.qxmd.com/read/38341954/big-data-analytics-for-mertk-genomics-reveals-its-double-edged-sword-functions-in-human-diseases
#27
JOURNAL ARTICLE
Shijie Liu, Jinzi Wu, Daixuan Yang, Jianliang Xu, Hang Shi, Bingzhong Xue, Zufeng Ding
RATIONALE: MER proto-oncogene tyrosine kinase (MerTK) is a key receptor for the clearance of apoptotic cells (efferocytosis) and plays important roles in redox-related human diseases. We will explore MerTK biology in human cells, tissues, and diseases based on big data analytics. METHODS: The human RNA-seq and scRNA-seq data about 42,700 samples were from NCBI Gene Expression Omnibus and analyzed by QIAGEN Ingenuity Pathway Analysis (IPA) with about 170,000 crossover analysis...
April 2024: Redox Biology
https://read.qxmd.com/read/38339164/immunological-profile-and-markers-of-endothelial-dysfunction-in-elderly-patients-with-cognitive-impairments
#28
JOURNAL ARTICLE
Nikolay V Goncharov, Polina I Popova, Igor V Kudryavtsev, Alexey S Golovkin, Irina V Savitskaya, Piotr P Avdonin, Ekaterina A Korf, Natalia G Voitenko, Daria A Belinskaia, Maria K Serebryakova, Natalia V Matveeva, Natalia O Gerlakh, Natalia E Anikievich, Marina A Gubatenko, Irina A Dobrylko, Andrey S Trulioff, Arthur D Aquino, Richard O Jenkins, Pavel V Avdonin
The process of aging is accompanied by a dynamic restructuring of the immune response, a phenomenon known as immunosenescence. Further, damage to the endothelium can be both a cause and a consequence of many diseases, especially in elderly people. The purpose of this study was to carry out immunological and biochemical profiling of elderly people with acute ischemic stroke (AIS), chronic cerebral circulation insufficiency (CCCI), prediabetes or newly diagnosed type II diabetes mellitus (DM), and subcortical ischemic vascular dementia (SIVD)...
February 4, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38334620/exploration-of-preservation-methods-for-utilizing-porcine-fetal-organ-derived-cells-in-regenerative-medicine-research
#29
JOURNAL ARTICLE
Kenji Matsui, Hidekazu Sekine, Jun Ishikawa, Shin Enosawa, Naoto Matsumoto, Yuka Inage, Yoshitaka Kinoshita, Keita Morimoto, Shutaro Yamamoto, Nagisa Koda, Shuichiro Yamanaka, Takashi Yokoo, Eiji Kobayashi
Human pluripotent stem cells have been employed in generating organoids, yet their immaturity compared to fetal organs and the limited induction of all constituent cell types remain challenges. Porcine fetal progenitor cells have emerged as promising candidates for co-culturing with human progenitor cells in regeneration and xenotransplantation research. This study focused on identifying proper preservation methods for porcine fetal kidneys, hearts, and livers, aiming to optimize their potential as cell sources...
January 25, 2024: Cells
https://read.qxmd.com/read/38321001/gitrl-impairs-hepatocyte-repopulation-by-liver-progenitor-cells-to-aggravate-inflammation-and-fibrosis-by-gitr-cd8-t-lymphocytes-in-cde-mice
#30
JOURNAL ARTICLE
Li Li, Yu He, Kai Liu, Lin Liu, Shan Shan, Helin Liu, Jiangbo Ren, Shujie Sun, Min Wang, Jidong Jia, Ping Wang
As an alternative pathway for liver regeneration, liver progenitor cells and their derived ductular reaction cells increase during the progression of many chronic liver diseases. However, the mechanism underlying their hepatocyte repopulation after liver injury remains unknown. Here, we conducted progenitor cell lineage tracing in mice and found that fewer than 2% of hepatocytes were derived from liver progenitor cells after 9 weeks of injury with a choline-deficient diet supplemented with ethionine (CDE), and this percentage increased approximately three-fold after 3 weeks of recovery...
February 6, 2024: Cell Death & Disease
https://read.qxmd.com/read/38320197/biliary-stem-cells-in-health-and-cholangiopathies-and-cholangiocarcinoma
#31
JOURNAL ARTICLE
Vincenzo Cardinale, Savino Paradiso, Domenico Alvaro
PURPOSE OF REVIEW: This review discusses evidence regarding progenitor populations of the biliary tree in the tissue regeneration and homeostasis, and the pathobiology of cholangiopathies and malignancies. RECENT FINDINGS: In embryogenesis biliary multipotent progenitor subpopulation contributes cells not only to the pancreas and gall bladder but also to the liver. Cells equipped with a constellation of markers suggestive of the primitive endodermal phenotype exist in the peribiliary glands, the bile duct glands, of the intra- and extrahepatic bile ducts...
March 1, 2024: Current Opinion in Gastroenterology
https://read.qxmd.com/read/38319104/unraveling-the-dynamics-of-hepatitis-c-virus-adaptive-mutations-and-their-impact-on-antiviral-responses-in-primary-human-hepatocytes
#32
JOURNAL ARTICLE
Nicola Frericks, Richard J P Brown, Birthe M Reinecke, Maike Herrmann, Yannick Brüggemann, Daniel Todt, Csaba Miskey, Florian W R Vondran, Eike Steinmann, Thomas Pietschmann, Julie Sheldon
Hepatitis C virus (HCV) infection progresses to chronicity in the majority of infected individuals. Its high intra-host genetic variability enables HCV to evade the continuous selection pressure exerted by the host, contributing to persistent infection. Utilizing a cell culture-adapted HCV population (p100pop) which exhibits increased replicative capacity in various liver cell lines, this study investigated virus and host determinants that underlie enhanced viral fitness. Characterization of a panel of molecular p100 clones revealed that cell culture adaptive mutations optimize a range of virus-host interactions, resulting in expanded cell tropism, altered dependence on the cellular co-factor micro-RNA 122 and increased rates of virus spread...
February 6, 2024: Journal of Virology
https://read.qxmd.com/read/38318851/depletion-of-smn-protein-in-mesenchymal-progenitors-impairs-the-development-of-bone-and-neuromuscular-junction-in-spinal-muscular-atrophy
#33
JOURNAL ARTICLE
Sang-Hyeon Hann, Seon-Yong Kim, Ye Lynne Kim, Young-Woo Jo, Jong-Seol Kang, Hyerim Park, Se-Young Choi, Young-Yun Kong
Spinal muscular atrophy (SMA) is a neuromuscular disorder characterized by the deficiency of the survival motor neuron (SMN) protein, which leads to motor neuron dysfunction and muscle atrophy. In addition to the requirement for SMN in motor neurons, recent studies suggest that SMN deficiency in peripheral tissues plays a key role in the pathogenesis of SMA. Using limb mesenchymal progenitor cell (MPC)-specific SMN-depleted mouse models, we reveal that SMN reduction in limb MPCs causes defects in the development of bone and neuromuscular junction (NMJ)...
February 6, 2024: ELife
https://read.qxmd.com/read/38306985/a-multi-tissue-metabolome-atlas-of-primate-pregnancy
#34
JOURNAL ARTICLE
Dainan Yu, Haifeng Wan, Chao Tong, Lu Guang, Gang Chen, Jiali Su, Lan Zhang, Yue Wang, Zhenyu Xiao, Jinglei Zhai, Long Yan, Wenwu Ma, Kun Liang, Taoyan Liu, Yuefan Wang, Zehang Peng, Lanfang Luo, Ruoxuan Yu, Wei Li, Hongbo Qi, Hongmei Wang, Ng Shyh-Chang
Pregnancy induces dramatic metabolic changes in females; yet, the intricacies of this metabolic reprogramming remain poorly understood, especially in primates. Using cynomolgus monkeys, we constructed a comprehensive multi-tissue metabolome atlas, analyzing 273 samples from 23 maternal tissues during pregnancy. We discovered a decline in metabolic coupling between tissues as pregnancy progressed. Core metabolic pathways that were rewired during primate pregnancy included steroidogenesis, fatty acid metabolism, and arachidonic acid metabolism...
February 1, 2024: Cell
https://read.qxmd.com/read/38296052/cdkn2a-p16-deletion-and-activated-kras-g12d-drive-barrett-s-like-gland-hyperplasia-metaplasia-and-synergize-in-the-development-of-dysplasia-pre-cancer-lesions
#35
JOURNAL ARTICLE
Jing Sun, Jorge L Sepulveda, Elena V Komissarova, Caitlin Hills, Tyler D Seckar, Narine M LeFevre, Hayk Simonyan, Colin Young, Gloria Su, Armando Del Portillo, Timothy C Wang, Antonia R Sepulveda
BACKGROUND & AIMS: Barrett's esophagus (BE) is the precursor of esophageal dysplasia and adenocarcinoma (EAC). CDKN2A-p16 deletions were reported in 34-74% of BE patients who progressed to dysplasia and EAC, suggesting that p16 loss may drive neoplastic progression. KRAS activation frequently occurs in EAC and pre-cancer lesions. LGR5+ stem cells in the squamocolumnar-junction (SCJ) of mouse stomach, contribute as BE progenitors. We aimed to determine the functional effects of p16 loss and KRAS activation in Barrett's-like metaplasia and dysplasia development...
January 29, 2024: Cellular and Molecular Gastroenterology and Hepatology
https://read.qxmd.com/read/38290102/modeling-primitive-and-definitive-erythropoiesis-with-induced-pluripotent-stem-cells
#36
JOURNAL ARTICLE
Giulia Pavani, Joshua G Klein, Catriana C Nations, Jonathan H Sussman, Kai Tan, Hyun Hyung An, Osheiza Abdulmalik, Christopher S Thom, Peter A Gearhart, Camryn Marie Willett, Jean Ann Maguire, Stella T Chou, Deborah L French, Paul Gadue
During development, erythroid cells are produced through at least two distinct hematopoietic waves (primitive and definitive), generating erythroblasts with different functional characteristics. Human induced pluripotent stem cells (iPSCs) can be used as a model platform to study red blood cell (RBC) development with many of the differentiation protocols following the primitive wave of hematopoiesis. Recent advances have established that definitive hematopoietic progenitors can be generated from iPSCs, creating a unique situation for comparing primitive and definitive erythrocytes derived from cell sources of identical genetic background...
January 30, 2024: Blood Advances
https://read.qxmd.com/read/38252699/implicating-the-cholecystokinin-b-receptor-in-liver-stem-cell-oncogenesis
#37
JOURNAL ARTICLE
Martha D Gay, Jack C Drda, Wenqiang Chen, Yimeng Huang, Amal A Yassin, Tetyana Duka, Hongbin Fang, Narayan Shivapurkar, Jill P Smith
Hepatocellular carcinoma (HCC) is the fastest growing cause of cancer-related deaths worldwide. Chronic inflammation and fibrosis are the greatest risk factors for the development of HCC. Although the cell of origin for HCC is uncertain, many theories believe this cancer may arise from liver progenitor cells or stem cells. Here, we describe the activation of hepatic stem cells that over-express the cholecystokinin-B receptor (CCK-BR) after liver injury with either a DDC diet (0.1% 3, 5-diethoxy-carbonyl 1,4-dihydrocollidine) or a NASH-inducing CDE diet (choline deficient ethionine) in murine models...
January 22, 2024: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://read.qxmd.com/read/38247843/trodusquemine-msi-1436-restores-metabolic-flexibility-and-mitochondrial-dynamics-in-insulin-resistant-equine-hepatic-progenitor-cells-hpcs
#38
JOURNAL ARTICLE
Badr Qasem, Agnieszka Dąbrowska, Jarosław Króliczewski, Jacek Łyczko, Krzysztof Marycz
Equine metabolic syndrome (EMS) is a significant global health concern in veterinary medicine. There is increasing interest in utilizing molecular agents to modulate hepatocyte function for potential clinical applications. Recent studies have shown promising results in inhibiting protein tyrosine phosphatase (PTP1B) to maintain cell function in various models. In this study, we investigated the effects of the inhibitor Trodusquemine (MSI-1436) on equine hepatic progenitor cells (HPCs) under lipotoxic conditions...
January 14, 2024: Cells
https://read.qxmd.com/read/38247453/oxidative-stress-and-redox-dependent-pathways-in-cholangiocarcinoma
#39
REVIEW
Alessandra Caligiuri, Matteo Becatti, Nunzia Porro, Serena Borghi, Fabio Marra, Mirella Pastore, Niccolò Taddei, Claudia Fiorillo, Alessandra Gentilini
Cholangiocarcinoma (CCA) is a primary liver tumor that accounts for 2% of all cancer-related deaths worldwide yearly. It can arise from cholangiocytes of biliary tracts, peribiliary glands, and possibly from progenitor cells or even hepatocytes. CCA is characterized by high chemoresistance, aggressiveness, and poor prognosis. Potentially curative surgical therapy is restricted to a small number of patients with early-stage disease (up to 35%). Accumulating evidence indicates that CCA is an oxidative stress-driven carcinoma resulting from chronic inflammation...
December 22, 2023: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38243869/linc-mir503hg-controls-sc-%C3%AE-cell-differentiation-and-insulin-production-by-targeting-cdh1-and-hes1
#40
JOURNAL ARTICLE
Yang Xu, Susu Mao, Haowen Fan, Jian Wan, Lin Wang, Mingyu Zhang, Shajun Zhu, Jin Yuan, Yuhua Lu, Zhiwei Wang, Bin Yu, Zhaoyan Jiang, Yan Huang
Stem cell-derived pancreatic progenitors (SC-PPs), as an unlimited source of SC-derived β (SC-β) cells, offers a robust tool for diabetes treatment in stem cell-based transplantation, disease modeling, and drug screening. Whereas, PDX1+ /NKX6.1+ PPs enhances the subsequent endocrine lineage specification and gives rise to glucose-responsive SC-β cells in vivo and in vitro. To identify the regulators that promote induction efficiency and cellular function maturation, single-cell RNA-sequencing is performed to decipher the transcriptional landscape during PPs differentiation...
January 20, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
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