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https://www.readbyqxmd.com/read/27919304/green-tea-extract-intake-during-lactation-modified-cardiac-macrophage-infiltration-and-amp-activated-protein-kinase-phosphorylation-in-weanling-rats-from-undernourished-mother-during-gestation-and-lactation
#1
E Matsumoto, S Kataoka, Y Mukai, M Sato, S Sato
Maternal dietary restriction is often associated with cardiovascular disease in offspring. The aim of this study was to investigate the effect of green tea extract (GTE) intake during lactation on macrophage infiltration, and activation of adenosine monophosphate (AMP)-activated protein kinase (AMPK) and serine-threonine kinase Akt (Akt) in the hearts of weanlings exposed to maternal dietary protein restriction. Pregnant Wistar rats were fed control (C) or low-protein diets (LP) throughout gestation. Following delivery, the dams received a control or a GTE-containing control diet during lactation: control diet during gestation and lactation (CC), low-protein diet during gestation and lactation (LPC), low-protein diet during gestation and 0...
December 6, 2016: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/27911610/successful-consecutive-expansion-of-limbal-explants-using-a-biosafe-culture-medium-under-feeder-layer-free-conditions
#2
Marina López-Paniagua, Teresa Nieto-Miguel, Ana de la Mata, Sara Galindo, José M Herreras, Rosa M Corrales, Margarita Calonge
PURPOSE: Transplantation of in vitro cultured limbal epithelial stem cells (LESCs) is a treatment widely used for LESC deficiency. However, the number of limbal tissue donors is limited, and protocols for LESC cultivation often include compounds and/or feeder layers that can induce side effects and/or increase the cost of the culture procedure. We investigated the feasibility of obtaining more than one limbal primary culture (LPC) from the same biopsy using a culture medium in which several potentially harmful compounds were replaced at the same time by biosafe supplements, allowing the LESC cultivation without feeder layers...
December 2, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27908498/hydrophilic-interaction-and-reversed-phase-mixed-mode-liquid-chromatography-coupled-to-high-resolution-tandem-mass-spectrometry-for-polar-lipids-analysis
#3
Sara Granafei, Pietro Azzone, Vito Alessandro Spinelli, Ilario Losito, Francesco Palmisano, Tommaso R I Cataldi
A hydrophilic interaction liquid chromatography (HILIC) fused-core column (150×2.1mm ID, 2.7μm particle size) and a short reversed-phase liquid chromatography (RPLC) column (20mm×2.1mm ID, 1.9μm) were serially coupled to perform mixed-mode chromatography (MMC) on complex mixtures of phospholipids (PL). Mobile phase composition and gradient elution program were, preliminarily, optimized using a mixture of phosphatidylcholines (PC), phosphatidylethanolamines (PE), their corresponding lyso-forms (LPC and LPE), and sphingomyelins (SM)...
November 25, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27895423/increased-cd4-cd45ra-foxp3-low-cells-alter-the-balance-between-treg-and-th17-cells-in-colitis-mice
#4
Ya-Hui Ma, Jie Zhang, Xue Chen, You-Fu Xie, Yan-Hua Pang, Xin-Juan Liu
AIM: To investigate the role of regulatory T cell (Treg) subsets in the balance between Treg and T helper 17 (Th17) cells in various tissues from mice with dextran sulfate sodium-induced colitis. METHODS: Treg cells, Treg cell subsets, Th17 cells, and CD4(+)CD25(+)FoxP3(+)IL-17(+) cells from the lamina propria of colon (LPC) and other ulcerative colitis (UC) mouse tissues were evaluated by flow cytometry. Forkhead box protein 3 (FoxP3), interleukin 17A (IL-17A), and RORC mRNA levels were assessed by real-time PCR, while interleukin-10 (IL-10) and IL-17A levels were detected with a Cytometric Beads Array...
November 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27892410/short-term-no2-exposure-is-associated-with-long-chain-fatty-acids-in-prospective-cohorts-from-augsburg-germany-results-from-an-analysis-of-138-metabolites-and-three-exposures
#5
Cavin K Ward-Caviness, Susanne Breitner, Kathrin Wolf, Josef Cyrys, Gabi Kastenmüller, Rui Wang-Sattler, Alexandra Schneider, Annette Peters
BACKGROUND: Short-term exposure to air pollution is associated with morbidity and mortality. Metabolites are intermediaries in biochemical processes, and associations between air pollution and metabolites can yield unique mechanistic insights. METHODS: We used independent cross-sectional samples with targeted metabolomics (138 metabolites across five metabolite classes) from three cohort studies, each a part of the Cooperative Health Research in the Region of Augsburg (KORA)...
October 2016: International Journal of Epidemiology
https://www.readbyqxmd.com/read/27883027/disturbed-phospholipid-homeostasis-in-endoplasmic-reticulum-initiates-tri-o-cresyl-phosphate-induced-delayed-neurotoxicity
#6
Li Zhu, Pan Wang, Ying-Jian Sun, Ming-Yuan Xu, Yi-Jun Wu
Tri-o-cresyl phosphate (TOCP) is a widely used organophosphorus compound, which can cause a neurodegenerative disorder, i.e., organophosphate-induced delayed neurotoxicity (OPIDN). The biochemical events in the initiation of OPIDN were not fully understood except for the essential inhibition of neuropathy target esterase (NTE). NTE, located in endoplasmic reticulum (ER), catalyzes the deacylation of phosphatidylcholine (PC) and lysophosphatidylcholine (LPC) to glycerophosphocholine (GPC). The present study aims to study the changes of ER phospholipids profile as well as levels of important intermediates of phospholipid synthesis such as diacylglycerol (DAG) and phosphatidic acid (PA) at the initiation stage of OPIDN...
November 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27872605/dissociating-the-electrophysiological-correlates-between-item-retrieval-and-associative-retrieval-in-associative-recognition-from-the-perspective-of-directed-forgetting
#7
Yujuan Wang, Xinrui Mao, Bingbing Li, Wei Wang, Chunyan Guo
Although many behavioral studies have reported associative memory was different from item memory, evidence coming from ERP researches has been in debate. In addition, directed forgetting effect for items has been fully discussed, but whether association between items can be directed-forgotten was unclear. The directed forgetting effect was important for dissociating the item retrieval and associative retrieval because of the one-to-one mapping relationship both between item retrieval and familiarity and between associative retrieval and recollection...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27871882/schistosomal-derived-lysophosphatidylcholine-triggers-m2-polarization-of-macrophages-through-ppar%C3%AE-dependent-mechanisms
#8
Leonardo Santos Assunção, Kelly G Magalhães, Alan Brito Carneiro, Raphael Molinaro, Patrícia E Almeida, Georgia C Atella, Hugo C Castro-Faria-Neto, Patrícia T Bozza
Mansonic schistosomiasis is a disease caused by the trematode Schistosoma mansoni, endemic to tropical countries. S. mansoni infection induces the formation of granulomas and potent polarization of Th2-type immune response. There is great interest in understanding the mechanisms used by this parasite that causes a modulation of the immune system. Recent studies from our group demonstrated that lipids of S. mansoni, including lysophosphatidylcholine (LPC) have immunomodulatory activity. In the present study, our aim was to investigate the role of lipids derived from S...
November 15, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27857199/neural-correlates-underlying-impaired-memory-facilitation-and-suppression-of-negative-material-in-depression
#9
Dandan Zhang, Hui Xie, Yunzhe Liu, Yuejia Luo
Previous behavioral studies demonstrated that depressed individuals have difficulties in forgetting unwanted, especially negative, event. However, inconsistent results still exit and the neural mechanism of this phenomenon has not been investigated. This study examined the intentional memory facilitation/suppression of negative and neutral materials in depression using Think/No-Think paradigm. We found that compared with nondepressed group, depressed group recalled more negative items, irrespective of either "Think" or "No-Think" instructions...
November 18, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27853831/role-of-the-lipid-regulated-nf-%C3%AE%C2%BAb-il-6-stat3-axis-in-alpha-naphthyl-isothiocyanate-induced-liver-injury
#10
Zhong-Ze Fang, Naoki Tanaka, Dan Lu, Chang-Tao Jiang, Wei-Hua Zhang, Chunze Zhang, Zuo Du, Zhi-Wei Fu, Peng Gao, Yun-Feng Cao, Hong-Zhi Sun, Zhi-Tu Zhu, Yan Cai, Kristopher W Krausz, Zhi Yao, Frank J Gonzalez
Alpha-naphthyl isothiocyanate (ANIT)-induced liver damage is regarded as a useful model to study drug-induced cholestatic hepatitis. Ultra-performance liquid chromatography coupled with electrospray ionization quadrupole mass spectrometry (UPLC-ESI-QTOF MS)-based metabolomics revealed clues to the mechanism of ANIT-induced liver injury, which facilitates the elucidation of drug-induced liver toxicity. 1-Stearoyl-2-hydroxy-sn-glycero-3-phosphocholine (LPC 18:0) and 1-oleoyl-2-hydroxy-sn-glycero-3-phosphocholine (LPC 18:1) were significantly increased in serum from ANIT-treated mice, and this increase resulted from altered expression of genes encoding the lipid metabolism enzymes Chka and Scd1...
November 16, 2016: Archives of Toxicology
https://www.readbyqxmd.com/read/27849246/margins-of-tolerance-and-reference-values-for-the-formant-vowels-for-use-in-voice-therapy-for-the-deaf-in-commercial-computer
#11
André Luis Maciel Leme, Márcio Abud Marcelino, Pedro Paulo Leite do Prado
Purpose: This study presents the margins of minimum and maximum tolerances for the frequencies of the first three formants (F1, F2, and F3) in the pronunciation of vowels of Brazilian Portuguese for use in voice therapy for the deaf. Methods: The frequencies were obtained from the voluntary collaboration of 53 adults who had their voices recorded and converted into digital signals during the phonation of each of the seven vowels (/a/, /e/, /Ɛ/, /i/, /o/, /ᴐ/, /u/) sustained for approximately one second...
September 2016: CoDAS
https://www.readbyqxmd.com/read/27845339/a-combination-of-muc5ac-and-ca19-9-improves-the-diagnosis-of-pancreatic-cancer-a-multicenter-study
#12
Sukhwinder Kaur, Lynette M Smith, Asish Patel, Melanie Menning, Duncan C Watley, Saad S Malik, Shiv Ram Krishn, Kavita Mallya, Abhijit Aithal, Aaron R Sasson, Sonny L Johansson, Maneesh Jain, Shailender Singh, Sushovan Guha, Chandrakanth Are, Massimo Raimondo, Michael A Hollingsworth, Randall E Brand, Surinder K Batra
OBJECTIVES: Pancreatic cancer (PC) is a lethal malignancy that lacks specific diagnostic markers. The present study explores the diagnostic potential of the most differentially overexpressed secretory mucin MUC5AC alone and in combination with CA19-9 using multi-center training and validation sets. METHODS: The expression of MUC5AC in benign pancreatic pathologies, PC precursor lesions, primary PC tissues and metastatic lesions was evaluated by immunohistochemistry...
November 15, 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27845031/the-temporal-dynamics-underlying-the-comprehension-of-scientific-metaphors-and-poetic-metaphors
#13
Xuemei Tang, Senqing Qi, Botao Wang, Xiaojuan Jia, Wei Ren
The neural mechanisms underlying the processing of novel metaphors created from poetic contexts have been investigated in previous experiments. Considering the different attributes of metaphors, the current study compared the temporal dynamics for processing two kinds of novel metaphors with event-related potentials (ERPs): scientific metaphors and poetic metaphors. Amplitudes of the N400 (350-450 ms) were similar for scientific metaphors and poetic metaphors. Within the LPC window (550-850 ms), ERPs associated with these two kinds of novel metaphors were observed every 100 ms in three successive subwindows...
November 11, 2016: Brain Research
https://www.readbyqxmd.com/read/27831558/ripk1-protects-from-tnf-%C3%AE-mediated-liver-damage-during-hepatitis
#14
Aveline Filliol, Claire Piquet-Pellorce, Jacques Le Seyec, Muhammad Farooq, Valentine Genet, Catherine Lucas-Clerc, John Bertin, Peter J Gough, Marie-Thérèse Dimanche-Boitrel, Peter Vandenabeele, Mathieu Jm Bertrand, Michel Samson
Cell death of hepatocytes is a prominent characteristic in the pathogenesis of liver disease, while hepatolysis is a starting point of inflammation in hepatitis and loss of hepatic function. However, the precise molecular mechanisms of hepatocyte cell death, the role of the cytokines of hepatic microenvironment and the involvement of intracellular kinases, remain unclear. Tumor necrosis factor alpha (TNF-α) is a key cytokine involved in cell death or survival pathways and the role of RIPK1 has been associated to the TNF-α-dependent signaling pathway...
November 10, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27829708/interleukin-22-might-act-as-a-double-edged-sword-in-type-2-diabetes-and-coronary-artery-disease
#15
Fangchen Gong, Jin Wu, Ping Zhou, Mengyao Zhang, Jingning Liu, Ying Liu, Xiang Lu, Zhengxia Liu
Type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD) are both characterized by chronic low-grade inflammation. The role of Th17 and its related cytokines in T2DM and CAD is unclear. Here we investigated the serum levels of five Th17-related cytokines (IL-17, IL-22, MIP-3α, IL-9, and IL-27) in T2DM, CAD, and T2DM-CAD comorbidity patients. IL-22 was found to be elevated in all three conditions. Elevated serum IL-22 was independently associated with the incidence of T2DM and CAD. Conversely, IL-22 was found to protect endothelial cells from glucose- and lysophosphatidylcholine- (LPC-) induced injury, and IL-22R1 expression on endothelial cells was increased upon treatment with high glucose and LPC...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27826058/the-progenitor-cell-dilemma-cellular-and-functional-heterogeneity-in-assistance-or-escalation-of-liver-injury
#16
REVIEW
Veronika Lukacs-Kornek, Frank Lammert
Liver progenitor cells (LPCs) are quiescent cells that are activated during liver injury and thought to give rise to hepatocytes and cholangiocytes in order to support liver regeneration and tissue restitution. While hepatocytes are capable of self-renewal, during most chronic injuries the proliferative capacity of hepatocytes is inhibited thus LPCs provide main source for regeneration. Despite extensive lineage tracing studies, their role and involvement in these processes are often controversial. Additionally, increasing evidence suggest that the LPC compartment consists of heterogeneous cell populations that are actively involved in cellular interactions with myeloid and lymphoid cells during regeneration...
November 5, 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/27825858/visually-guided-auditory-attention-in-a-dynamic-cocktail-party-speech-perception-task-erp-evidence-for-age-related-differences
#17
Dr Stephan Getzmann, Edmund Wascher
Speech understanding in the presence of concurring sound is a major challenge especially for older persons. In particular, conversational turn-takings usually result in switch costs, as indicated by declined speech perception after changes in the relevant target talker. Here, we investigated whether visual cues indicating the future position of a target talker may reduce the costs of switching in younger and older adults. We employed a speech perception task, in which sequences of short words were simultaneously presented by three talkers, and analysed behavioural measures and event-related potentials (ERPs)...
November 4, 2016: Hearing Research
https://www.readbyqxmd.com/read/27821758/mapping-human-temporal-and-parietal-neuronal-population-activity-and-functional-coupling-during-mathematical-cognition
#18
Amy L Daitch, Brett L Foster, Jessica Schrouff, Vinitha Rangarajan, Itır Kaşikçi, Sandra Gattas, Josef Parvizi
Brain areas within the lateral parietal cortex (LPC) and ventral temporal cortex (VTC) have been shown to code for abstract quantity representations and for symbolic numerical representations, respectively. To explore the fast dynamics of activity within each region and the interaction between them, we used electrocorticography recordings from 16 neurosurgical subjects implanted with grids of electrodes over these two regions and tracked the activity within and between the regions as subjects performed three different numerical tasks...
November 7, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27815167/calcium-independent-binding-of-human-c-reactive-protein-to-lysophosphatidylcholine-in-supported-planar-phospholipid-monolayers
#19
Tatsuro Goda, Yuji Miyahara
: Details describing the molecular dynamics of inflammation biomarker human C-reactive protein (CRP) on plasma membranes containing bioactive lipid lysophosphatidylcholine (LPC) remain elusive. Here, we measured the binding kinetics of CRP to supported phospholipid monolayers deposited on an alkanethiol self-assembled monolayer on a planar gold substrate using surface plasmon resonance. Surprisingly, CRP binding to supported 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC)/LPC monolayers was calcium-independent although CRP binding to supported POPC monolayers was calcium-dependent...
November 1, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27814564/switching-of-auditory-attention-in-cocktail-party-listening-erp-evidence-of-cueing-effects-in-younger-and-older-adults
#20
Stephan Getzmann, Julian Jasny, Michael Falkenstein
Verbal communication in a "cocktail-party situation" is a major challenge for the auditory system. In particular, changes in target speaker usually result in declined speech perception. Here, we investigated whether speech cues indicating a subsequent change in target speaker reduce the costs of switching in younger and older adults. We employed event-related potential (ERP) measures and a speech perception task, in which sequences of short words were simultaneously presented by four speakers. Changes in target speaker were either unpredictable or semantically cued by a word within the target stream...
November 1, 2016: Brain and Cognition
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