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https://www.readbyqxmd.com/read/29783268/lipidomic-components-alterations-of-human-follicular-fluid-reveal-the-relevance-of-improving-clinical-outcomes-in-women-using-progestin-primed-ovarian-stimulation-compared-to-short-term-protocol
#1
Xiaowei Wen, Yanping Kuang, Lixia Zhou, Baofeng Yu, Qiuju Chen, Yonglun Fu, Zheng Yan, Haiyan Guo, Qifeng Lyu, Jun Xie, Weiran Chai
BACKGROUND Increasing the success rate of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) is a duty of clinicians that has made many seek a variety of protocols. This study was undertaken to use a liquid chromatography-mass spectrometry (LC-MS) to define the alterations of follicular fluid (FF) lipid metabolites in patients undergoing progestin-primed ovarian stimulation (PPOS) compared with short-term protocol, revealing potential correlations between the differentially expressed lipids and ameliorative clinical outcomes...
May 21, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29774420/lysophosphatidylcholine-as-a-predictor-of-postoperative-complications-after-colorectal-cancer-surgery
#2
Akihisa Matsuda, Marina Yamada, Satoshi Matsumoto, Nobuyuki Sakurazawa, Takeshi Yamada, Takeshi Matsutani, Masao Miyashita, Eiji Uchida
PURPOSE: Lysophosphatidylcholine (LPC), which is generated from phosphatidylcholine (PC) and metabolized by autotaxin (ATX), modulates immune responses via its anti-inflammatory property. We investigated the association between LPC and postoperative complications (POCs) after colorectal cancer surgery (CRC). METHODS: The subjects of this study were 43 patients who underwent surgery for CRC. Peripheral blood samples were collected preoperatively and immediately after surgery, and on postoperative days (PODs) 1, 3, 5, and 7...
May 17, 2018: Surgery Today
https://www.readbyqxmd.com/read/29769317/lysophospholipids-induce-innate-immune-transdifferentiation-of-endothelial-cells-resulting-in-prolonged-endothelial-activation
#3
Xinyuan Li, Luqiao Wang, Pu Fang, Yu Sun, Xiaohua Jiang, Hong Wang, Xiao-Feng Yang
Innate immune cells express danger-associated molecular pattern (DAMP) receptors, T-cell co-stimulation/co-inhibition receptors, and the major histocompatibility complex II (MHC-II). We have recently proposed that endothelial cells can serve as innate immune cells, but the molecular mechanisms involved still await discovery. Here, we investigated whether human aortic endothelial cells (HAECs) could be transdifferentiated into innate immune cells by exposing them to hyperlipidemia-upregulated DAMP molecules, i...
May 16, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29764481/a-total-pleural-covering-of-absorbable-cellulose-mesh-prevents-pneumothorax-recurrence-in-patients-with-birt-hogg-dub%C3%A3-syndrome
#4
Teruaki Mizobuchi, Masatoshi Kurihara, Hiroki Ebana, Sumitaka Yamanaka, Hideyuki Kataoka, Shouichi Okamoto, Etsuko Kobayashi, Toshio Kumasaka, Kuniaki Seyama
BACKGROUND: Birt-Hogg-Dubé syndrome (BHDS) is a recently recognized inherited multiple cystic lung disease causing recurrent pneumothoraces. Similarly to the lesions in patients with lymphangioleiomyomatosis (LAM), the pulmonary cysts are innumerable and widely dispersed and cannot all be removed. We recently described a total pleural covering (TPC) that covers the entire visceral pleura with oxidized regenerated cellulose (ORC) mesh. TPC successfully prevented the recurrence of pneumothorax in LAM patients...
May 15, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29758238/electrophysiological-correlates-of-timbre-imagery-and-perception
#5
Przemysław Tużnik, Paweł Augustynowicz, Piotr Francuz
The primary objective of the present study was to verify whether the differences in imagined timbre are reflected by the event-related potentials (ERPs). It was verified the hypotheses that imagining of sounds, varying in spectral characteristics of timbre, influence the amplitude of the late positive component (LPC), associated with auditory imagery-related processes. It was also verified whether the manipulation of the perceived timbre corresponds to the amplitude fluctuations of the auditory evoked potentials (AEPs) N1 and P2...
May 11, 2018: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/29755479/lysophosphatidylcholine-promotes-phagosome-maturation-and-regulates-inflammatory-mediator-production-through-the-protein-kinase-a-phosphatidylinositol-3-kinase-p38-mitogen-activated-protein-kinase-signaling-pathway-during-mycobacterium-tuberculosis-infection
#6
Hyo-Ji Lee, Hyun-Jeong Ko, Dong-Kun Song, Yu-Jin Jung
Tuberculosis is caused by the infectious agent Mycobacterium tuberculosis (Mtb). Mtb has various survival strategies, including blockade of phagosome maturation and inhibition of antigen presentation. Lysophosphatidylcholine (LPC) is a major phospholipid component of oxidized low-density lipoprotein and is involved in various cellular responses, such as activation of second messengers and bactericidal activity in neutrophils. In this study, macrophages were infected with a low infectious dose of Mtb and treated with LPC to investigate the bactericidal activity of LPC against Mtb...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29737914/lipidomics-reveal-aryl-hydrocarbon-receptor-ahr-regulated-lipid-metabolic-pathway-in-alpha-naphthyl-isothiocyanate-anit-induced-intrahepatic-cholestasis
#7
Bao-Long Wang, Chang-Wen Zhang, Liang Wang, Kun-Long Tang, Naoki Tanaka, Frank J Gonzalez, Yong Xu, Zhong-Ze Fang
1. Ultra-performance liquid chromatography coupled with electrospray ionization quadrupole mass spectrometry (UPLC-ESI-QTOF MS)-based lipidomics was employ to elucidate new mechanism of alpha-naphthyl isothiocyanate (ANIT)-induced intrahepatic cholestasis in mice. 2. Multiple lipid components significantly increased in ANIT-induced intrahepatic cholestasis, including PC 16:0, 20:4, PC 16:0, 22:6, PC 16:0, 18:2, LPC 18:2, PC 18:2, LPC 18:1, PC 18:1, 14:0, SM 18:1, 16:0, oleoylcarnitine, and palmitoylcarnitine...
May 8, 2018: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/29730168/adenosine-a-2a-receptor-blockade-attenuates-spatial-memory-deficit-and-extent-of-demyelination-areas-in-lyolecithin-induced-demyelination-model
#8
Atefeh Akbari, Mohsen Khalili-Fomeshi, Manouchehr Ashrafpour, Ali Akbar Moghadamnia, Maryam Ghasemi-Kasman
In recent years, inactivation of A2A adenosine receptors has been emerged as a novel strategy for treatment of several neurodegenerative diseases. Although numerous studies have shown the beneficial effects of A2A receptors blockade on spatial memory, the impacts of selective adenosine A2A receptors on memory performance has not yet been examined in the context of demyelination. In the present study, we evaluated the effect of A2A receptor antagonist SCH58261 on spatial memory and myelination in an experimental model of focal demyelination in rat fimbria...
May 3, 2018: Life Sciences
https://www.readbyqxmd.com/read/29724434/visual-criterion-for-evaluating-hepatobiliary-phase-image-acquisition-of-gadolinium-ethoxybenzyl-diethylenetriaminepentaacetic-acid-enhanced-mri
#9
Y Takatsu, M Nakamura, S Kobayashi, T Miyati
AIM: To evaluate the hepatobiliary phase (HBP) of liver magnetic resonance imaging (MRI) using gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid, and report a visual criterion based on the portal vein (PV), which can be used as a substitute for the quantitative liver-spleen contrast ratio (Q-LSC). MATERIALS AND METHODS: In HBP images of 167 patients, a visual criterion was established based on the sufficient contrast between the liver parenchyma (LP) and PV...
April 30, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29720729/electrophysiological-dynamics-of-chinese-phonology-during-visual-word-recognition-in-chinese-english-bilinguals
#10
Yun Wen, Ruth Filik, Walter J B van Heuven
Silent word reading leads to the activation of orthographic (spelling), semantic (meaning), as well as phonological (sound) information. For bilinguals, native language information can also be activated automatically when they read words in their second language. For example, when Chinese-English bilinguals read words in their second language (English), the phonology of the Chinese translations is automatically activated. Chinese phonology, however, consists of consonants and vowels (segmental) and tonal information...
May 2, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29718662/high-spatial-resolution-imaging-of-mouse-pancreatic-islets-using-nanospray-desorption-electrospray-ionization-mass-spectrometry
#11
Ruichuan Yin, Jennifer E Kyle, Kristin E Burnum-Johnson, Kent Bloodsworth, Lori Sussel, Charles Ansong, Julia Laskin
Nanospray Desorption Electrospray Ionization mass spectrometry imaging (nano-DESI MSI) enables ambient imaging of biological samples with high sensitivity and minimal sample pretreatment. Recently, we developed an approach for constant-distance mode MSI using shear force microscopy to precisely control the distance between the sample and the nano-DESI probe. Herein, we demonstrate the power of this approach for robust imaging of pancreatic islets with high spatial resolution of ~11 μm. Pancreatic islets are difficult to characterize using traditional mass spectrometry approaches due to their small size (~100 μm) and molecular heterogeneity...
May 2, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29710749/a-novel-hand-gesture-recognition-method-based-on-2-channel-semg
#12
Hailong Yu, Xueli Fan, Lebin Zhao, Xiaoyang Guo
Hand gesture recognition is getting more and more important in the area of rehabilitation and human machine interface (HMI). However, most current approaches are difficult to achieve practical application because of an excess of sensors. In this work, we proposed a method to recognize six common hand gestures and establish the optimal relationship between hand gesture and muscle by utilizing only two channels of surface electromyography (sEMG). We proposed an integrated approach to process the sEMG data including filtering, endpoint detection, feature extraction, and classifier...
April 14, 2018: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/29691716/properties-and-structure-of-a-low-potential-penta-heme-cytochrome-c-552-from-a-thermophilic-purple-sulfur-photosynthetic-bacterium-thermochromatium-tepidum
#13
Jing-Hua Chen, Long-Jiang Yu, Alain Boussac, Zheng-Yu Wang-Otomo, Tingyun Kuang, Jian-Ren Shen
The thermophilic purple sulfur bacterium Thermochromatium tepidum possesses four main water-soluble redox proteins involved in the electron transfer behavior. Crystal structures have been reported for three of them: a high potential iron-sulfur protein, cytochrome c', and one of two low-potential cytochrome c 552 (which is a flavocytochrome c) have been determined. In this study, we purified another low-potential cytochrome c 552 (LPC), determined its N-terminal amino acid sequence and the whole gene sequence, characterized it with absorption and electron paramagnetic spectroscopy, and solved its high-resolution crystal structure...
April 24, 2018: Photosynthesis Research
https://www.readbyqxmd.com/read/29690953/stat3-regulates-liver-progenitor-cell-driven-liver-regeneration-in-zebrafish
#14
Mehwish Khaliq, Sungjin Ko, Yinzi Liu, Hualin Wang, Yonghua Sun, Lila Solnica-Kreze, Donghun Shin
After liver injury, regeneration manifests as either (1) hepatocytes proliferating to restore the lost hepatocyte massor (2) if hepatocyte proliferation is compromised, biliary epithelial cells (BECs) dedifferentiating into liver progenitor cells (LPCs), which subsequently differentiate into hepatocytes. Following pharmacogenetic ablation of hepatocytes in Tg(fabp10a:CFP-NTR) zebrafish, resulting in severe liver injury, signal transducer and activator of transcription 3 (Stat3) and its target gene and negative regulator, socs3a , were upregulated in regenerating livers...
April 24, 2018: Gene Expression
https://www.readbyqxmd.com/read/29680773/changes-in-the-hippocampal-and-peripheral-phospholipid-profiles-are-associated-with-neurodegeneration-hallmarks-in-a-long-term-global-cerebral-ischemia-model-attenuation-by-linalool
#15
Angélica Maria Sabogal-Guáqueta, Rafael Posada-Duque, Natalie Charlotte Cortes, Julian D Arias-Londoño, Gloria Patricia Cardona-Gómez
Phospholipid alterations in the brain are associated with progressive neurodegeneration and cognitive impairment after acute and chronic injuries. Various types of treatments have been evaluated for their abilities to block the progression of the impairment, but effective treatments targeting long-term post-stroke alterations are not available. In this study, we analyzed changes in the central and peripheral phospholipid profiles in ischemic rats and determined whether a protective monoterpene, Linalool, could modify them...
April 19, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29679909/mechanisms-of-the-active-components-from-korean-pine-nut-preventing-and-treating-d-galactose-induced-aging-rats
#16
Jianmei Zhang, Weiwei Lin, Ruijun Wu, Yanmeng Liu, Kai Zhu, Jinyu Ren, Sufang Zhang, Xiaomei Ling
Age-related neuronal injury and oxidative damage are the predominant factors for neurodegenerative diseases like Alzheimer's disease (AD). The aim of this study was to explore whether chronic administration of d-galactose (d-gal) can cause neuronal injury and oxidative damage, and to investigate the neuroprotective and antioxidative effects of the active components (UPNO-1) from Korean pine nut (Pinus koraiensis). Two dosing regimens were designed, one for the evaluation of preventive effects in which the rats were simultaneously administrated d-gal and UPNO-1/fishoil for 12 weeks, the other for the evaluation of therapeutic effects in which the rats were given d-gal for 8 weeks before treated with UPNO-1/selegiline for 8 weeks...
April 18, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29620892/hydroxamic-acids-constitute-a-novel-class-of-autotaxin-inhibitors-that-exhibit-in-vivo-efficacy-in-a-pulmonary-fibrosis-model
#17
Aikaterini Nikolaou, Ioanna Ninou, Maroula G Kokotou, Eleanna Kaffe, Antreas Afantitis, Vassilis Aidinis, George Kokotos
Autotaxin (ATX) catalyzes the hydrolysis of lysophosphatidylcholine (LPC) generating the lipid mediator lysophosphatidic acid (LPA). Both ATX and LPA are involved in various pathological inflammatory conditions, including fibrosis and cancer, and have attracted a great interest as medicinal targets over the last decade. Thus, the development of novel potent ATX inhibitors is of great importance. We have developed a novel class of ATX inhibitors containing the zinc binding functionality of hydroxamic acid. Such novel hydroxamic acids, that incorporate a non-natural δ-amino acid residue, exhibit high in vitro inhibitory potency over ATX (IC50 values 50-60 nM)...
April 5, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29615656/how-semantic-radicals-in-chinese-characters-facilitate-hierarchical-category-based-induction
#18
Xiaoxi Wang, Xie Ma, Yun Tao, Yachen Tao, Hong Li
Prior studies indicate that the semantic radical in Chinese characters contains category information that can support the independent retrieval of category information through the lexical network to the conceptual network. Inductive reasoning relies on category information; thus, semantic radicals may influence inductive reasoning. As most natural concepts are hierarchically structured in the human brain, this study examined how semantic radicals impact inductive reasoning for hierarchical concepts. The study used animal and plant nouns, organized in basic, superordinate, and subordinate levels; half had a semantic radical and half did not...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29596956/individual-differences-in-infants-neural-responses-to-their-peers-cry-and-laughter
#19
Maria Magdalena Crespo-Llado, Ross E Vanderwert, Elena Geangu
Infants' ability to process others' emotional expressions is fundamental for their social development. While infants' processing of emotions expressed by faces and speech has been more extensively investigated, less is known about how infants process non-verbal vocalizations of emotions. Here, we recorded frontal N100, P200, and LPC event-related potentials (ERPs) from 8-month-old infants listening to sounds of other infants crying, laughing, and coughing. Infants' temperament was measured via parental report...
March 26, 2018: Biological Psychology
https://www.readbyqxmd.com/read/29588370/intrinsic-properties-and-plasma-membrane-trafficking-route-of-src-family-kinase-sh4-domains-sensitive-to-retargeting-by-hiv-1-nef
#20
Amanda J Chase, Rebecka Wombacher, Oliver T Fackler
The HIV-1 pathogenicity factor Nef enhances viral replication by modulating multiple host cell pathways, including tuning the activation state of infected CD4 T lymphocytes to optimize virus spread. For this, Nef inhibits anterograde transport of the Src family kinase (SFK) Lck toward the plasma membrane (PM). This leads to retargeting of the kinase to the trans-Golgi network (TGN), while the intracellular transport of a related SFK, Fyn, is unaffected by Nef. The 18 amino acid SH4 domain membrane anchor of Lck is necessary and sufficient for Nef-mediated retargeting, but other details of this process are not known...
March 27, 2018: Journal of Biological Chemistry
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