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https://www.readbyqxmd.com/read/28716612/impulsive-personality-dimensions-are-associated-with-altered-behavioral-performance-and-neural-responses-in-the-monetary-incentive-delay-task
#1
Ruolei Gu, Yang Jiang, Seth Kiser, Chelsea L Black, Lucas S Broster, Yue-Jia Luo, Thomas H Kelly
Individual differences in dimensions of impulsivity personality including disinhibition and sensation seeking modulate approach responses to reinforcing stimuli, such as drugs and money. The current study examined the effects of monetary incentive on both behavioral performance and electrophysiological activity among individuals varying in disinhibition and sensation seeking. The monetary incentive delay (MID) task was completed under electroencephalogram (EEG) recording. Behavioral data showed that higher disinhibition and sensation-seeking were associated with lower performance accuracy...
July 14, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28715731/metabolomics-analysis-reveals-that-benzo-a-pyrene-a-component-of-pm2-5-promotes-pulmonary-injury-by-modifying-lipid-metabolism-in-a-phospholipase-a2-dependent-manner-in-vivo-and-in-vitro
#2
Song-Yang Zhang, Danqing Shao, Huiying Liu, Juan Feng, Baihuan Feng, Xiaoming Song, Qian Zhao, Ming Chu, Changtao Jiang, Wei Huang, Xian Wang
Particulate matter with an aerodynamic diameter less than 2.5μM (PM2.5) is one of the major environmental pollutants in China. In this study, we carried out a metabolomics profile study on PM2.5-induced inflammation. PM2.5 from Beijing, China, was collected and given to rats through intra-tracheal instillation in vivo. Acute pulmonary injury were observed by pulmonary function assessment and H.E. staining. The lipid metabolic profile was also altered with increased phospholipid and sphingolipid metabolites in broncho-alveolar lavage fluid (BALF) after PM2...
July 4, 2017: Redox Biology
https://www.readbyqxmd.com/read/28714685/adsorption-coupled-diffusion-of-gold-nanoclusters-within-a-large-pore-protein-crystal-scaffold
#3
Luke F Hartje, Brian E Munsky, Thomas W Ni, Christopher J Ackerson, Christopher D Snow
Large-pore protein crystals (LPCs) are ordered biologically-derived nanoporous materials exhibiting pore diameters greater than 8 nm. These substantial pores distinguish LPCs from typical nanoporous scaffolds; enabling engineered LPC materials to readily uptake, immobilize, and release macromolecular guests. In this study, macromolecular transport within an LPC environment has been experimentally and computationally investigated by studying adsorption-coupled diffusion of Au25(glutathione)18 nanoclusters within a crosslinked LPC scaffold via time-lapse confocal microscopy, bulk equilibrium adsorption, and hindered diffusion simulation...
July 17, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28714104/chronic-inflammation-elicited-liver-progenitor-cell-conversion-to-liver-cancer-stem-cell-with-clinical-significance
#4
Xiao-Feng Li, Cheng Chen, Dai-Min Xiang, Le Qu, Wen Sun, Xin-Yuan Lu, Teng-Fei Zhou, Shu-Zhen Chen, Bei-Fang Ning, Zhuo Cheng, Ming-Yang Xia, Wei-Feng Shen, Wen Yang, Wen Wen, Terence Kin Wah Lee, Wen-Ming Cong, Hong-Yang Wang, Jin Ding
The substantial heterogeneity and hierarchical organization in liver cancer supports the theory of liver cancer stem cell (LCSC). However, the relationship between chronic hepatic inflammation and LCSC generation remains obscure. Here we observed a close correlation between aggravated inflammation and liver progenitor cell (LPC) propagation in the cirrhotic liver of rats exposed to diethylnitrosamine. LPCs isolated from the rat cirrhotic liver initiated subcutaneous liver cancers in NOD/SCID mice, suggesting the malignant transformation of LPC toward LCSC...
July 17, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28708712/extended-second-window-of-protection-of-sevoflurane-induced-preconditioning
#5
Friederike Behmenburg, Yvonne Boekholt, Patrick van Caster, Marianne Dorsch, André Heinen, Markus W Hollmann, Ragnar Huhn
Late preconditioning (LPC) can be induced by volatile anesthetics and initiates cardioprotection against ischemia/reperfusion injury for three to four days. We investigated the possibility to extend the time window of sevoflurane-induced LPC by repeated sevoflurane administration. An in vivo rat model of regional myocardial ischemia/reperfusion injury was used. Myocardial infarct size was determined by TTC staining at the end of the experiment. In the first series of experiments, male Wistar rats were randomized to five groups (each n=8)...
July 13, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28706479/impact-of-semantic-relatedness-on-associative-memory-an-erp-study
#6
Pierre Desaunay, Patrice Clochon, Franck Doidy, Anna Lambrechts, Dermot M Bowler, Priscille Gérardin, Jean-Marc Baleyte, Francis Eustache, Bérengère Guillery-Girard
Encoding and retrieval processes in memory for pairs of pictures are thought to be influenced by inter-item similarity and by features of individual items. Using Event-Related Potentials (ERP), we aimed to identify how these processes impact on both the early mid-frontal FN400 and the Late Positive Component (LPC) potentials during associative retrieval of pictures. Twenty young adults undertook a sham task, using an incidental encoding of semantically related and unrelated pairs of drawings. At test, we conducted a recognition task in which participants were asked to identify target identical pairs of pictures, which could be semantically related or unrelated, among new and rearranged pairs...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28705360/do-inferences-of-competence-from-faces-predict-political-selection-in-authoritarian-regimes-evidence-from-china
#7
Stan Hok-Wui Wong, Yu Zeng
Candidate appearance is a significant predictor of election outcomes in democracies because voters often make inference of competence based on facial appearance. Do inferences of competence from faces matter in autocracies? In this article, we study the effects of candidate appearance on the selection of three types of Chinese officials: (1) rural deputies elected to a local people's congress (LPC), (2) urban deputies elected to the LPC, and (3) unelected mayors and bureaucrats. We find that facial competence cues are relevant only to the votes received by rural LPC candidates...
August 2017: Social Science Research
https://www.readbyqxmd.com/read/28683445/lysophosphatidylcholine-acyltransferase-3-expression-is-associated-with-atherosclerosis-progression
#8
Hiroki Tanaka, Nobuhiro Zaima, Takeshi Sasaki, Naoto Yamamoto, Kazunori Inuzuka, Tatsuro Yata, Takayuki Iwaki, Kazuo Umemura, Hideto Sano, Yuko Suzuki, Tetsumei Urano, Mitsutoshi Setou, Naoki Unno
Free arachidonic acid (AA) is an important precursor of lipid mediators such as leukotrienes and prostaglandins that induces inflammation and is associated with atherosclerosis progression. Recent studies have shown that lysophosphatidylcholine acyltransferase-3 (LPCAT3) converts lysophosphatidylcholine (LPC) and free AA into phosphatidylcholine (PC)-containing AA (arachidonyl-PC) and thereby can regulate intracellular free-AA levels. However, the association between LPCAT3 and atherosclerosis remains to be established...
July 6, 2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28683338/encoding-focus-alters-diagnostic-recollection-and-event-related-potentials-erps
#9
P Andrew Leynes, Brittany A Mok
The influence of encoding focus on source memory was investigated using event-related potentials (ERPs). Encoding was focused on the self (self-focus) or on the speaker (other-focus) while hearing words spoken in a male or female voice. Examination of the behavioral and ERP evidence suggests that encoding focus alters the amount of diagnostic recollection. Self-focus encoding produced more positive encoding ERPs, led to greater old/new recognition, and elicited a greater Late Positive Component (LPC; the putative neural correlate of recollection) during the source test...
July 3, 2017: Brain and Cognition
https://www.readbyqxmd.com/read/28628031/kinase-independent-functions-of-ripk1-regulate-hepatocyte-survival-and-liver-carcinogenesis
#10
Trieu-My Van, Apostolos Polykratis, Beate Katharina Straub, Vangelis Kondylis, Nikoletta Papadopoulou, Manolis Pasparakis
The mechanisms that regulate cell death and inflammation play an important role in liver disease and cancer. Receptor-interacting protein kinase 1 (RIPK1) induces apoptosis and necroptosis via kinase-dependent mechanisms and exhibits kinase-independent prosurvival and proinflammatory functions. Here, we have used genetic mouse models to study the role of RIPK1 in liver homeostasis, injury, and cancer. While ablating either RIPK1 or RelA in liver parenchymal cells (LPCs) did not cause spontaneous liver pathology, mice with combined deficiency of RIPK1 and RelA in LPCs showed increased hepatocyte apoptosis and developed spontaneous chronic liver disease and cancer that were independent of TNF receptor 1 (TNFR1) signaling...
June 30, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28611717/n450-and-lpc-event-related-potential-correlates-of-an-emotional-stroop-task-with-words-differing-in-valence-and-emotional-origin
#11
Kamil K Imbir, Tomasz Spustek, Joanna Duda, Gabriela Bernatowicz, Jarosław Żygierewicz
Affective meaning of verbal stimuli was found to influence cognitive control as expressed in the Emotional Stroop Task (EST). Behavioral studies have shown that factors such as valence, arousal, and emotional origin of reaction to stimuli associated with words can lead to lengthening of reaction latencies in EST. Moreover, electrophysiological studies have revealed that affective meaning altered amplitude of some components of evoked potentials recorded during EST, and that this alteration correlated with the performance in EST...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28607433/lipidomic-analysis-of-skeletal-muscle-tissues-of-p53-knockout-mice-by-nuplc-esi-ms-ms
#12
Se Mi Park, Seul Kee Byeon, Hojun Lee, Hyerim Sung, Il Yong Kim, Je Kyung Seong, Myeong Hee Moon
Tumour suppressor p53 is known to be associated with the maintenance of mitochondrial functional properties in the skeletal muscles. As deactivation or mutation of p53 can affect the synthesis of lipids, investigating the relationship between p53-related energy generation metabolism and perturbation of lipid profile is critical. In this study, 329 lipid species (among 412 identified species) in two different skeletal muscle tissues (the gastrocnemius and soleus) from p53 knockout (KO) mice were quantitatively analysed using nanoflow ultrahigh performance liquid chromatography tandem mass spectrometry (nUPLC-MS/MS)...
June 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28602806/the-overall-fatty-acid-absorption-controlled-by-basolateral-chylomicron-excretion-under-regulation-of-p-jnk1
#13
Wolfgang Stremmel, Simone Staffer, Andreas Wannhoff, Anita Pathil
Suppression of fatty acid absorption is one goal to fight obesity. However, the responsible molecular mechanism is poorly understood. Aim of the present study was the search for the key regulator of the overall fatty acid absorption mechanism and its pharmaceutical modulation. As experimental tool we employed the polarized human intestinal tumor derived cell line CaCo2. Here we showed that influx of fatty acids is mediated by an apical heterotetrameric plasma membrane protein complex of which the calcium-independent membrane phospholipase A2 (iPLA2ß) is one constituent...
June 6, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28599080/bmp-signaling-governs-biliary-driven-liver-regeneration-in-zebrafish-via-tbx2b-and-id2a
#14
Tae-Young Choi, Mehwish Khaliq, Shinya Tsurusaki, Nikolay Ninov, Didier Y R Stainier, Minoru Tanaka, Donghun Shin
Upon mild liver injury, new hepatocytes originate from pre-existing hepatocytes. However, if hepatocyte proliferation is impaired, a manifestation of severe liver injury, biliary epithelial cells (BECs) contribute to new hepatocytes through BEC dedifferentiation into liver progenitor cells (LPCs), also termed oval cells or hepatoblast-like cells (HB-LCs), and subsequent differentiation into hepatocytes. Despite the identification of several factors regulating BEC dedifferentiation and activation, little is known about factors involved in the regulation of LPC differentiation into hepatocytes during liver regeneration...
June 9, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28572881/association-between-dairy-intake-lipids-and-vascular-structure-and-function-in-diabetes
#15
Kristina S Petersen, Jennifer B Keogh, Natalie Lister, Jacquelyn M Weir, Peter J Meikle, Peter M Clifton
AIM: To determine lipid species that change in response to a change in dairy consumption. In addition, to investigate whether dairy associated lipid species are correlated with changes in measures of vascular structure and function. METHODS: A 12-mo randomised controlled trial was conducted to determine the effect of increased consumption of fruit, vegetables and dairy, compared to usual diet, on measures of vascular structure and function in adults with type 1 and type 2 diabetes (n = 108)...
May 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28572751/effect-of-probiotic-supplementation-on-total-lactobacilli-bifidobacteria-and-short-chain-fatty-acids-in-2-5-year-old-children
#16
R Hemalatha, A C Ouwehand, M T Saarinen, U V Prasad, K Swetha, V Bhaskar
​Background: Consumption of Lactobacillus paracasei Lpc-37 or Bifidobacterium lactis HN019 by 2-5-year-old children was found to reduce risk for diarrhoea and fever during the rainy season. Objective: Can changes in faecal short chain fatty acids (SCFAs) or branched chain fatty acids (BCFAs) explain the observed positive influence of probiotics and their role on nutritional status and diarrhoea risk? Design: Faecal samples were analysed for SCFAs and BCFAs and correlated to Bifidobacterium and Lactobacillus levels; both at the start and after nine months' consumption of either of the two probiotic strains, or placebo...
2017: Microbial Ecology in Health and Disease
https://www.readbyqxmd.com/read/28558307/electrophysiological-signals-associated-with-fluency-of-different-levels-of-processing-reveal-multiple-contributions-to-recognition-memory
#17
Bingbing Li, Jason R Taylor, Wei Wang, Chuanji Gao, Chunyan Guo
Processing fluency appears to influence recognition memory judgements, and the manipulation of fluency, if misattributed to an effect of prior exposure, can result in illusory memory. Although it is well established that fluency induced by masked repetition priming leads to increased familiarity, manipulations of conceptual fluency have produced conflicting results, variously affecting familiarity or recollection. Some recent studies have found that masked conceptual priming increases correct recollection (Taylor & Henson, 2012), and the magnitude of this behavioural effect correlates with analogous fMRI BOLD priming effects in brain regions associated with recollection (Taylor, Buratto, & Henson, 2013)...
May 27, 2017: Consciousness and Cognition
https://www.readbyqxmd.com/read/28552522/lysophosphatidylcholine-elicits-intracellular-calcium-signaling-in-a-gpr55-dependent-manner
#18
Anna Drzazga, Agata Sowinska, Agnieszka Krzeminska, Przemysław Rytczak, Maria Koziolkiewicz, Edyta Gendaszewska-Darmach
The GPR55 signaling is fertile ground for drug discovery, however despite considerable research progress during the past 10 years, many open questions remain. The GPR55 pharmacology remains controversial, as many ligands have been reported with inconsistent results. Here, we show that various molecular species of lysophosphatidylcholine (LPC) elicit intracellular Ca(2+) mobilization in GPR55-expressing PC-3 human prostate carcinoma cells. The response was even stronger than [Ca(2+)]i flux evoked by endogenous (OEA) and synthetic (Abn-CBD) agonists...
July 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28543218/the-time-course-of-indirect-moral-judgment-in-gossip-processing-modulated-by-different-agents
#19
Xiaozhe Peng, Can Jiao, Fang Cui, Qingfei Chen, Peng Li, Hong Li
Previous studies have investigated personal moral violations with different references (i.e., the protagonists in moral scenarios are the participants themselves or unknown other individuals). However, the roles of various agents in moral judgments have remained unclear. In the present study, ERPs were used to investigate moral judgments when the participants viewed gossip that described (im)moral behaviors committed by different agents (self, friend, celebrity). The results demonstrate that the P2 and late positive component (LPC) correspond to two successive processes of indirect moral judgment when individuals process gossip...
May 24, 2017: Psychophysiology
https://www.readbyqxmd.com/read/28541505/the-impact-of-personal-relevance-on-emotion-processing-evidence-from-event-related-potentials-and-pupillary-responses
#20
Mareike Bayer, Katja Ruthmann, Annekathrin Schacht
Emotional stimuli attract attention and lead to increased activity in the visual cortex. The present study investigated the impact of personal relevance on emotion processing by presenting emotional words within sentences that referred to participants' significant others or to unknown agents. In event-related potentials, personal relevance increased visual cortex activity within 100 ms after stimulus onset and the amplitudes of the Late Positive Complex (LPC). Moreover, personally relevant contexts gave rise to augmented pupillary responses and higher arousal ratings, suggesting a general boost of attention and arousal...
May 25, 2017: Social Cognitive and Affective Neuroscience
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