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https://www.readbyqxmd.com/read/29695316/pain-catastrophizing-behaviors-and-their-relation-to-poor-patient-reported-outcomes-after-scapular-muscle-reattachment
#1
W Ben Kibler, Cale A Jacobs, Aaron D Sciascia
HYPOTHESIS: We hypothesized that the patient-reported status following treatment of traumatic scapular muscle detachment would improve from the preoperative status and that higher pain catastrophizing scores would be more common in patients with poor postsurgical outcomes. METHODS: We studied 50 patients who met the diagnostic criteria for scapular muscle detachment and in whom rehabilitation failed. American Shoulder and Elbow Surgeons (ASES) scores were collected preoperatively and postoperatively...
April 23, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29690953/stat3-regulates-liver-progenitor-cell-driven-liver-regeneration-in-zebrafish
#2
Mehwish Khaliq, Sungjin Ko, Yinzi Liu, Hualin Wang, Yonghua Sun, Lila Solnica-Kreze, Donghun Shin
After liver injury, regeneration manifests as either (1) hepatocytes proliferating to restore the lost hepatocyte massor (2) if hepatocyte proliferation is compromised, biliary epithelial cells (BECs) dedifferentiating into liver progenitor cells (LPCs), which subsequently differentiate into hepatocytes. Following pharmacogenetic ablation of hepatocytes in Tg(fabp10a:CFP-NTR) zebrafish, resulting in severe liver injury, signal transducer and activator of transcription 3 (Stat3) and its target gene and negative regulator, socs3a , were upregulated in regenerating livers...
April 24, 2018: Gene Expression
https://www.readbyqxmd.com/read/29673755/understanding-liver-regeneration-from-mechanisms-to-regenerative-medicine
#3
REVIEW
Hélène Gilgenkrantz, Alexandra Collin de l'Hortet
Liver regeneration is a complex and unique process. When two-thirds of a mouse liver is removed, the remaining liver recovers its initial weight in approximately 10 days. The understanding of the mechanisms responsible for liver regeneration may help patients needing large liver resections or transplantation and may be applied to the field of regenerative medicine. All differentiated hepatocytes are capable of self-renewal, but different subpopulations of hepatocytes seem to have distinct proliferative abilities...
April 16, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29555973/analysis-of-the-neurotoxic-effects-of-neuropathic-organophosphorus-compounds-in-adult-zebrafish
#4
Melissa Faria, Inmaculada Fuertes, Eva Prats, Jose Luis Abad, Francesc Padrós, Cristian Gomez-Canela, Josefina Casas, Jorge Estevez, Eugenio Vilanova, Benjamin Piña, Demetrio Raldúa
Inhibition and aging of neuropathy target esterase (NTE) by exposure to neuropathic organophosphorus compounds (OPs) can result in OP-induced delayed neuropathy (OPIDN). In the present study we aimed to build a model of OPIDN in adult zebrafish. First, inhibition and aging of zebrafish NTE activity were characterized in the brain by using the prototypic neuropathic compounds cresyl saligenin phosphate (CBDP) and diisopropylphosphorofluoridate (DFP). Our results show that, as in other animal models, zebrafish NTE is inhibited and aged by both neuropathic OPs...
March 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29513773/guided-bone-regeneration-in-the-treatment-of-a-lateral-periodontal-cyst-2-year-clinical-and-radiologic-follow-up
#5
Stefano Sivolella, Chiara Perin, Marco Capecchi, Valerio Buongiorno, Marialuisa Valente
Lateral periodontal cysts (LPCs) are rare odontogenic cysts of developmental origin. A 52-year-old man presented with an asymptomatic gingival swelling located between the mandibular left canine and first premolar, both of which were vital. Radiography showed a well-circumscribed radiolucent area and loss of the lamina dura around the tooth socket in contact with the lesion and of the interproximal buccal bone. The lesion was enucleated. The defect was immediately grafted with a 1:1 mixed autologous and heterologous bone graft covered with a collagen membrane...
March 7, 2018: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/29507906/interleukins-17-and-27-promote-liver-regeneration-by-sequentially-inducing-progenitor-cell-expansion-and-differentiation
#6
Adrien Guillot, Imène Gasmi, Arthur Brouillet, Yeni Ait-Ahmed, Julien Calderaro, Isaac Ruiz, Bin Gao, Sophie Lotersztajn, Jean-Michel Pawlotsky, Fouad Lafdil
Liver progenitor cells (LPCs)/ductular reactions (DRs) are associated with inflammation and implicated in the pathogenesis of chronic liver diseases. However, how inflammation regulates LPCs/DRs remains largely unknown. Identification of inflammatory processes that involve LPC activation and expansion represent a key step in understanding the pathogenesis of liver diseases. In the current study, we found that diverse types of chronic liver diseases are associated with elevation of infiltrated interleukin (IL)-17-positive (+) cells and cytokeratin 19 (CK19)+ LPCs, and both cell types colocalized and their numbers positively correlated with each other...
March 2018: Hepatology Communications
https://www.readbyqxmd.com/read/29454887/metabolomic-analysis-uncovered-an-association-of-serum-phospholipid-levels-with-estrogen-induced-mammary-tumors-in-female-aci-seg-rats
#7
Yoshinori Okamoto, Akira Aoki, Koji Ueda, Hideto Jinno
Estrogen is reported to be involved in mammary tumorigenesis. To unveil metabolic signatures for estrogen-induced mammary tumorigenesis, we carried out serum metabolomic analysis in an estrogen-induced mammary tumor model, female August Copenhagen-Irish/Segaloff (ACI/Seg) rats, using liquid chromatography-mass spectrometry. In contrast to the control group, all rats with an implanted 17β-estradiol (E2) pellet developed mammary tumors during this experiment. E2 treatment significantly suppressed body weight gain...
May 15, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29429020/leukemia-propagating-cells-demonstrate-distinctive-gene-expression-profiles-compared-with-other-cell-fractions-from-patients-with-de-novo-philadelphia-chromosome-positive-all
#8
COMPARATIVE STUDY
Hong-Yan Zhao, Yang Song, Xie-Na Cao, Ya-Zhen Qin, Yue-Yun Lai, Hao Jiang, Qian Jiang, Xiao-Jun Huang, Yuan Kong
Relapse remains one of the major obstacles in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) even after allogeneic hematopoietic stem cell transplantation. The persistence of leukemia-propagating cells (LPCs) may lead to the recurrence of Ph+ ALL. Using a xenograft assay, LPCs enrichment in the CD34+ CD38- CD58- fraction in Ph+ ALL was recently identified. A further cohort study indicated that the LPCs phenotype at diagnosis was an independent risk factor for relapse of Ph+ ALL. However, little is known about the potential molecular mechanism of LPCs-mediated relapse...
May 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29424576/immunohistochemical-and-electron-microscopic-morphometric-image-analysis-of-hepatocellular-carcinoma-in-association-of-hcv-infection
#9
Sarah Hassan, Soheir S Mansy, Sahar A Tabak, Ahmed S AbdelFattah, Ahmed M Abdel-Aziz, Olfat Hamam, Mohammed I Seleem, Amr Abdelaal
Early detection of hepatocellular carcinoma (HCC) is crucial for successful therapy. The present work examined the value of ultrastructural morphometric image analysis of hepatocyte nuclei in patients with chronic hepatitis C virus (HCV) versus HCC cases with chronic HCV and the corresponding surgical tumor-free safe margins (TFMs), to highlight any early predictive signs of neoplastic cellular transformation. This work also performed an immunohistochemical assessment of cytokeratin 19 (CK19) and Ki-67-positive cells to visualize any associated proliferative activity in the examined groups...
March 2018: Ultrastructural Pathology
https://www.readbyqxmd.com/read/29414354/a-high-temporal-spatial-vehicle-emission-inventory-based-on-detailed-hourly-traffic-data-in-a-medium-sized-city-of-china
#10
Yong-Hong Liu, Jin-Ling Ma, Li Li, Xiao-Fang Lin, Wei-Jia Xu, Hui Ding
To improve the accuracy and temporal-spatial resolution for a vehicle emission inventory in a medium-sized city with a strip road network, this study was conducted based on detailed hourly traffic-flow data for each day of 2014, and covered all road types and regions in the city of Foshan. Detailed hourly emission characteristics and sources in five regions were analysed. The results showed that the total vehicle emissions of CO, NOX , VOCs, and PM2.5 were 13.10 × 104 , 0.23 × 104 , 4.46 × 104 , and 0...
May 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29402770/cord-blood-lysophosphatidylcholine-16-1-is-positively-associated-with-birth-weight
#11
Yong-Ping Lu, Christoph Reichetzeder, Cornelia Prehn, Liang-Hong Yin, Chen Yun, Shufei Zeng, Chang Chu, Jerzy Adamski, Berthold Hocher
BACKGROUND/AIMS: Impaired birth outcomes, like low birth weight, have consistently been associated with increased disease susceptibility to hypertension in later life. Alterations in the maternal or fetal metabolism might impact on fetal growth and influence birth outcomes. Discerning associations between the maternal and fetal metabolome and surrogate parameters of fetal growth could give new insight into the complex relationship between intrauterine conditions, birth outcomes, and later life disease susceptibility...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29225068/lysophosphatidylcholine-and-its-phosphorothioate-analogues-potentiate-insulin-secretion-via-gpr40-ffar1-gpr55-and-gpr119-receptors-in-a-different-manner
#12
Anna Drzazga, Hjalti Kristinsson, Maciej Sałaga, Hubert Zatorski, Maria Koziołkiewicz, Edyta Gendaszewska-Darmach, Peter Bergsten
Lysophosphatidylcholine (LPC) is an endogenous ligand for GPR119 receptor, mediating glucose-stimulated insulin secretion (GSIS). We demonstrate that LPC facilitates GSIS in MIN6 pancreatic β-cell line and murine islets of Langerhans by recognizing not only GPR119 but also GPR40 (free fatty acid receptor 1) and GPR55 activated by lysophosphatidylinositol. Natural LPCs are unstable when administered in vivo limiting their therapeutic value and therefore, we present phosphorothioate LPC analogues with increased stability...
December 8, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29156092/gingival-cyst-of-the-adult-lateral-periodontal-cyst-and-botryoid-odontogenic-cyst-an-updated-systematic-review
#13
REVIEW
B R Chrcanovic, R S Gomez
The aim of the present review was to integrate the available data published on gingival cyst of the adult (GCA), lateral periodontal cyst (LPC), and botryoid odontogenic cyst (BOC) into a comprehensive analysis of their clinical/radiological features. An electronic search was undertaken in July/2017. Eligibility criteria included publications having enough clinical/radiological/histological information to confirm the diagnosis. A total of 146 publications (157 GCAs, 213 LPCs, 96 BOCs) were included. GCA and LPC presented highest prevalence in the sixth/fifth decades; BOC in the sixth/seventh decades...
November 20, 2017: Oral Diseases
https://www.readbyqxmd.com/read/29129603/a-rapid-quantitative-analysis-of-bile-acids-lysophosphatidylcholines-and-polyunsaturated-fatty-acids-in-biofluids-based-on-ultraperformance-liquid-chromatography-coupled-with-triple-quadrupole-tandem-massspectrometry
#14
Zhangxiao Peng, Qian Zhang, Ziming Mao, Jie Wang, Chunying Liu, Xuejing Lin, Xin Li, Weidan Ji, Jianhui Fan, Maorong Wang, Changqing Su
Much evidence suggested that quantitative analysis of bile acids (BAs), lysophosphatidylcholines (LPCs), and polyunsaturated fatty acids (PUFAs) in biofluids may be very useful for diagnosis and prevention of hepatobiliary disease with a non-invasive manner. However, simultaneously fast analysis of these metabolites has been challenging for their huge differences of physicochemical properties and concentration levels in biofluids. In this study, we present a liquid chromatography-mass spectrometry method with a high throughput analytical cycle (10min) to fast and accurately quantify fifteen potential biomarkers (eight BAs, four LPCs and three PUFAs) of hepatobiliary disease...
November 15, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29117232/rate-of-acyl-migration-in-lysophosphatidylcholine-lpc-is-dependent-upon-the-nature-of-the-acyl-group-greater-stability-of-sn-2-docosahexaenoyl-lpc-compared-to-the-more-saturated-lpc-species
#15
Dhavamani Sugasini, Papasani V Subbaiah
Several previous studies reported that sn-2 acyl lysophosphatidylcholines (LPCs) undergo rapid isomerization due to acyl migration, especially at physiological pH and temperature. However, these studies have been carried out using mostly sn-2 palmitoyl LPC, whereas the naturally occurring sn-2 LPCs are predominantly unsaturated. In this study, we investigated the acyl migration in four naturally occurring sn-2 acyl LPCs (sn-2 16:0, sn-2 18:1, sn-2 20:4, and sn-2 22:6) stored at various temperatures in aqueous or organic solvents, employing LC/MS to analyze the isomer composition...
2017: PloS One
https://www.readbyqxmd.com/read/29079451/2-ome-lysophosphatidylcholine-analogues-are-gpr119-ligands-and-activate-insulin-secretion-from-%C3%AE-tc-3-pancreatic-cells-evaluation-of-structure-dependent-biological-activity
#16
Anna Drzazga, Agata Sowińska, Agnieszka Krzemińska, Andrzej Okruszek, Piotr Paneth, Maria Koziołkiewicz, Edyta Gendaszewska-Darmach
GPR119 receptor has been proposed as a metabolic regulator playing a pivotal role in the modulation of glucose homeostasis in type 2 diabetes. GPR119 was identified on pancreatic β cells and its ligands have the ability to enhance glucose-stimulated insulin secretion (GSIS). Lysophosphatidylcholine (LPC) was shown to potentiate GSIS and our present studies indicate that 2-methoxy-lysophosphatidylcholine (2-OMe-LPC) analogues, unable to undergo 1→2 acyl migration, stimulate GSIS from murine βTC-3 pancreatic cells even more efficiently...
January 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29066962/self-referential-information-alleviates-retrieval-inhibition-of-directed-forgetting-effects-an-erp-evidence-of-source-memory
#17
Xinrui Mao, Yujuan Wang, Yanhong Wu, Chunyan Guo
Directed forgetting (DF) assists in preventing outdated information from interfering with cognitive processing. Previous studies pointed that self-referential items alleviated DF effects due to the elaboration of encoding processes. However, the retrieval mechanism of this phenomenon remains unknown. Based on the dual-process framework of recognition, the retrieval of self-referential information was involved in familiarity and recollection. Using source memory tasks combined with event-related potential (ERP) recording, our research investigated the retrieval processes of alleviative DF effects elicited by self-referential information...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29056548/human-induced-pluripotent-stem-cell-derived-lung-progenitor-and-alveolar-epithelial-cells-attenuate-hyperoxia-induced-lung-injury
#18
Mehdi Shafa, Lavinia Iuliana Ionescu, Arul Vadivel, Jennifer J P Collins, Liqun Xu, Shumei Zhong, Martin Kang, Geneviève de Caen, Manijeh Daneshmand, Jenny Shi, Katherine Z Fu, Andrew Qi, Ying Wang, James Ellis, William L Stanford, Bernard Thébaud
BACKGROUND AIMS: Bronchopulmonary dysplasia (BPD), a chronic lung disease characterized by disrupted lung growth, is the most common complication in extreme premature infants. BPD leads to persistent pulmonary disease later in life. Alveolar epithelial type 2 cells (AEC2s), a subset of which represent distal lung progenitor cells (LPCs), promote normal lung growth and repair. AEC2 depletion may contribute to persistent lung injury in BPD. We hypothesized that induced pluripotent stem cell (iPSC)-derived AECs prevent lung damage in experimental oxygen-induced BPD...
January 2018: Cytotherapy
https://www.readbyqxmd.com/read/29052842/shear-stress-upregulates-regeneration-related-immediate-early-genes-in-liver-progenitors-in-3d-ecm-like-microenvironments
#19
Kenichiro Nishii, Erik Brodin, Taylor Renshaw, Rachael Weesner, Emma Moran, Shay Soker, Jessica L Sparks
The role of fluid stresses in activating the hepatic stem/progenitor cell regenerative response is not well understood. This study hypothesized that immediate early genes (IEGs) with known links to liver regeneration will be upregulated in liver progenitor cells (LPCs) exposed to in vitro shear stresses on the order of those produced from elevated interstitial flow after partial hepatectomy. The objectives were: (1) to develop a shear flow chamber for application of fluid stress to LPCs in 3D culture; and (2) to determine the effects of fluid stress on IEG expression in LPCs...
May 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28961775/brain-responses-at-encoding-predict-limited-verbal-memory-retrieval-by-persons-with-schizophrenia
#20
Julia M Longenecker, Noah C Venables, Seung Suk Kang, Kathryn A McGuire, Scott R Sponheim
Objective: Special attention has been given to verbal memory deficits in schizophrenia because they are apparent in healthy biological relatives of affected individuals, indicating a link to genetic risk for the disorder. Despite a growing consensus that encoding abnormalities contribute to poor verbal memory in the disorder, few studies have directly examined how neural responses during encoding contribute to later memory performance. Method: We evaluated event-related potentials (ERPs) during encoding of verbal material by patients with schizophrenia, healthy first-degree biological relatives of patients, and healthy controls...
September 15, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
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