David Conen, Ekaterine Popova, Michael Ke Wang, Matthew T V Chan, Giovanni Landoni, Cara Reimer, Sadeesh K Srinathan, Juan P Cata, Sean R McLean, Juan Carlos Trujillo Reyes, Ascensión Martín Grande, Anna Gonzalez Tallada, Daniel I Sessler, Edith Fleischmann, Donna E Maziak, Barbara Kabon, Luca Voltolini, Laura Gutiérrez-Soriano, Vikas Tandon, Deborah DuMerton, Biniam Kidane, Ravi Rajaram, Yaron Shargall, John D Neary, Jennifer R Wells, William F McIntyre, Steffen Blum, Sandra N Ofori, Jessica Vincent, Lizhen Xu, Zhuoru Li, Jeff S Healey, Amit X Garg, P J Devereaux
BACKGROUND: Perioperative atrial fibrillation (AF) and myocardial injury after noncardiac surgery (MINS) are common complications after noncardiac surgery. Inflammation has been implicated in the pathogenesis of both disorders. The COP-AF trial tests the hypothesis that colchicine reduces the incidence of perioperative AF and MINS in patients undergoing major noncardiac thoracic surgery. METHODS AND RESULTS: The 'COlchicine for the Prevention of Perioperative Atrial Fibrillation' (COP-AF) trial is an international, blinded, randomized trial that compares colchicine to placebo in patients aged at least 55 years and undergoing major noncardiac thoracic surgery with general anesthesia...
May 2023: American Heart Journal