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https://www.readbyqxmd.com/read/29239812/dosimetric-impact-of-inter-observer-catheter-reconstruction-variability-in-ultrasound-based-high-dose-rate-prostate-brachytherapy
#1
Alexandru Nicolae, Jure Murgic, Ivan Kruljac, Lior Dubnitzky, Laura D'Alimonte, Lin Lu, Aaron Cumal, Niki Law, Gerard Morton, Andrew Loblaw, Hans T Chung, Ananth Ravi
PURPOSE: To investigate the dosimetric impact of interobserver catheter reconstruction variability in transrectal ultrasound-guided prostate high-dose-rate (HDR) brachytherapy. METHODS AND MATERIALS: Twenty consecutive patients with intermediate- or high-risk prostate cancer were treated with a single, 15-Gy HDR brachytherapy boost as part of this study. The treated plan was used as the study reference plan (PR). Three expert treatment planners (observers) manually reconstructed the catheter paths on the static three-dimensional transrectal ultrasound images, and new plans were generated from the updated positions (POBS); subsequently, the dwell time and positions from the POBS plans were superimposed on the PR catheter paths to evaluate the dosimetric effect of the interobserver variations (PEVAL)...
November 24, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29223915/marijuana-buyers-in-the-united-states-2010-2014
#2
Alejandro Azofeifa, Laura J Sherman, Margaret E Mattson, Rosalie L Pacula
BACKGROUND: Obtaining or purchasing marijuana in the U.S. can be done only in certain states via a lawful market, for medical or non-medical (recreational) purposes, or via an unlawful market ("black market") by home cultivation and unlicensed vendors and individuals. Given the evolving U.S. state marijuana legislation landscape, the objective of this study is to describe individuals who report buying marijuana in the past year by selected characteristics and U.S. geographical location...
December 5, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29205995/volume-and-health-outcomes-evidence-from-systematic-reviews-and-from-evaluation-of-italian-hospital-data
#3
Laura Amato, Danilo Fusco, Anna Acampora, Katia Bontempi, Alessandro Cesare Rosa, Paola Colais, Fabio Cruciani, Mariangela D'Ovidio, Francesca Mataloni, Silvia Minozzi, Zuzana Mitrova, Luigi Pinnarelli, Rosella Saulle, Salvatore Soldati, Chiara Sorge, Simona Vecchi, Martina Ventura, Marina Davoli
BACKGROUND Improving quality and effectiveness of healthcare is one of the priorities of health policies. Hospital or physician volume represents a measurable variable with an impact on effectiveness of healthcare. An Italian law calls for the definition of «qualitative, structural, technological, and quantitative standards of hospital care». There is a need for an evaluation of the available scientific evidence in order to identify qualitative, structural, technological, and quantitative standards of hospital care, including the volume of care above or below which the public and private hospitals may be accredited (or not) to provide specific healthcare interventions...
September 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/29140582/abortion-knowledge-and-experiences-among-u-s-servicewomen-a-qualitative-study
#4
Kate Grindlay, Jane W Seymour, Laura Fix, Sarah Reiger, Brianna Keefe-Oates, Daniel Grossman
CONTEXT: U.S. servicewomen have a higher rate of unintended pregnancy than civilian women, yet the military does not provide or cover abortion, except in limited circumstances. Servicewomen's experiences with abortion care have received little research attention. METHODS: Twenty-one in-depth interviews with servicewomen who had had an abortion during active-duty service in the prior two years were conducted between January 2015 and July 2016. Women reported on their experiences accessing abortion, as well as their knowledge and opinions of the military's abortion policy...
November 15, 2017: Perspectives on Sexual and Reproductive Health
https://www.readbyqxmd.com/read/29126116/c-621-15-w-and-others-v-sanofi-pasteur-an-example-of-judicial-distortion-and-indifference-to-science
#5
Laura R Smillie, Mark R Eccleston-Turner, Sarah L Cooper
This case commentary examines the CJEU's recent decision in C-621/15 W and Others v Sanofi Pasteur MSD SNC [2017] ECR I. This commentary critically examines the decision through the lens of the cultural conflict between law and science. We argue that the CJEU's decision reflects both a distortion of scientific knowledge and an improper indifference to the legitimate methods by which scientific knowledge is generated in the context of vaccines. These judicial approaches may, the authors argue, inadvertently fuel the vaccine scepticism that is growing across the developed world, and in particular in Europe...
November 8, 2017: Medical Law Review
https://www.readbyqxmd.com/read/29119763/-systematic-review-of-safeness-and-therapeutic-efficacy-of-cannabis-in-patients-with-multiple-sclerosis-neuropathic-pain-and-in-oncological-patients-treated-with-chemotherapy
#6
REVIEW
Laura Amato, Silvia Minozzi, Zuzana Mitrova, Elena Parmelli, Rosella Saulle, Fabio Cruciani, Simona Vecchi, Marina Davoli
BACKGROUND: medical cannabis refers to the use of cannabis or cannabinoids as medical therapy to treat disease or alleviate symptoms. In the United States, 23 states and Washington DC (May 2015) have introduced laws to permit the medical use of cannabis. Within the European Union, medicinal cannabis laws and praxis vary wildly between Countries. OBJECTIVES: to provide evidence for benefits and harms of cannabis (including extracts and tinctures) treatment for adults in the following indications: control of spasticity and pain in patients with multiple sclerosis; control of pain in patients with chronic neuropathic pain; control of nausea and vomiting in adults with cancer receiving chemotherapy...
September 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/29119305/the-development-and-psychometric-properties-of-the-immigration-law-concerns-scale-ilcs-for-hiv-testing
#7
Julia Lechuga, Carol L Galletly, Michelle R Broaddus, Julia B Dickson-Gomez, Laura R Glasman, Timothy L McAuliffe, Miriam Y Vega, Sarah LeGrand, Carla A Mena, Morgan L Barlow, Erik Valera, Judith I Montenegro
To develop, pilot test, and conduct psychometric analyses of an innovative scale measuring the influence of perceived immigration laws on Latino migrants' HIV-testing behavior. The Immigration Law Concerns Scale (ILCS) was developed in three phases: Phase 1 involved a review of law and literature, generation of scale items, consultation with project advisors, and subsequent revision of the scale. Phase 2 involved systematic translation- back translation and consensus-based editorial processes conducted by members of a bilingual and multi-national study team...
November 8, 2017: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/29119186/ion-dehydration-controls-adsorption-at-the-micellar-interface-hydrotropic-ions
#8
Filipe S Lima, Marcos F C Andrade, Laura Mortara, Luís Gustavo Dias, Iolanda M Cuccovia, Hernan Chaimovich
The properties of ionic micelles depend on the nature of the counterion, and these effects become more evident as the ion adsorption at the interface increases. Prediction of the relative extent of ion adsorption is required for rational design of ionic micellar aggregates. Unlike the well understood adsorption of monatomic ions, the adsorption of polyatomic ions is not easily predicted. We combined experimental and computational methods to evaluate the affinity of hydrotropic ions, i.e., ions with polar and apolar regions, to the surface of positively charged micelles...
November 22, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29117104/current-status-of-legislation-on-dietary-products-for-sportspeople-in-a-european-framework
#9
REVIEW
José Miguel Martínez-Sanz, Isabel Sospedra, Eduard Baladía, Laura Arranz, Rocío Ortiz-Moncada, Angel Gil-Izquierdo
The consumption of nutritional ergogenic aids is conditioned by laws/regulations, but standards/regulations vary between countries. The aim of this review is to explore legislative documents that regulate the use of nutritional ergogenic aids intended for sportspeople in a Spanish/European framework. A narrative review has been developed from official websites of Spanish (Spanish Agency of the Consumer, Food Safety, and Nutrition) and European (European Commission and European Food Safety Authority) bodies...
November 8, 2017: Nutrients
https://www.readbyqxmd.com/read/29112651/progesterone-for-prevention-of-preterm-birth-shortcomings-and-unintended-consequences-of-the-orphan-drug-act
#10
Rebekah E Gee, SreyRam Kuy, Laura O Karas
Preterm birth is a problem of major public health significance that continues to plague our country despite the existence of a therapy, 17α-hydroxyprogesterone caproate, with known efficacy in reducing the risk of spontaneous preterm birth among high-risk women. Over the past several years, the Louisiana Department of Health has undertaken a robust, multifaceted initiative to improve access to 17α-hydroxyprogesterone caproate, which resulted in a 3.5-fold increase in the percentage of eligible high-risk pregnant women in the Medicaid program who received the therapy between 2013 and 2016...
November 3, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29071349/tanning-salon-compliance-rates-in-states-with-legislation-to-protect-youth-access-to-uv-tanning
#11
Melissa S Williams, Brittany Buhalog, Laura Blumenthal, Erik J Stratman
Importance: The US Food and Drug Administration has classified tanning beds as carcinogenic. Most states have enacted legislation to prevent or create barriers for minors accessing tanning establishments. Determining tanning salon compliance with legislation would provide an indication of the influence of legislation at preventing exposure to the carcinogen in minors. Objectives: To investigate compliance rates in the 42 states and the District of Columbia with legislation restricting tanning bed use in minors and to identify differences in compliance based on population, regional location, salon ownership, age group being regulated, and time since the law was enacted...
October 25, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/29066720/chiral-transcription-in-self-assembled-tetrahedral-eu4l6-chiral-cages-displaying-sizable-circularly-polarized-luminescence
#12
Chi-Tung Yeung, King-Him Yim, Ho-Yin Wong, Robert Pal, Wai-Sum Lo, Siu-Cheong Yan, Melody Yee-Man Wong, Dmitry Yufit, Danil E Smiles, Laura J McCormick, Simon J Teat, David K Shuh, Wing-Tak Wong, Ga-Lai Law
Predictable stereoselective formation of supramolecular assembly is generally believed to be an important but complicated process. Here, we show that point chirality of a ligand decisively influences its supramolecular assembly behavior. We designed three closely related chiral ligands with different point chiralities, and observe their self-assembly into europium (Eu) tetrametallic tetrahedral cages. One ligand exhibits a highly diastereoselective assembly into homochiral (either ΔΔΔΔ or ΛΛΛΛ) Eu tetrahedral cages whereas the two other ligands, with two different approaches of loosened point chirality, lead to a significant breakdown of the diastereoselectivity to generate a mixture of (ΔΔΔΔ and ΛΛΛΛ) isomers...
October 24, 2017: Nature Communications
https://www.readbyqxmd.com/read/29065200/basic-science-and-public-policy-informed-regulation-for-nicotine-and-tobacco-products
#13
Christie D Fowler, Cassandra D Gipson, Bethea A Kleykamp, Laura E Rupprecht, Paul T Harrell, Vaughan W Rees, Thomas J Gould, Jason Oliver, Deniz Bagdas, M Imad Damaj, Heath D Schmidt, Alexander Duncan, Mariella De Biasi
Introduction: Scientific discoveries over the past few decades have provided significant insight into the abuse liability and negative health consequences associated with tobacco and nicotine-containing products. While many of these advances have led to the development of policies and laws that regulate access to and formulations of these products, further research is critical to guide future regulatory efforts, especially as novel nicotine-containing products are introduced and selectively marketed to vulnerable populations...
August 3, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29028654/to-the-editor
#14
Laura V Duggan, J Adam Law, Ian R Morris
No abstract text is available yet for this article.
October 15, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28985266/enabling-research-in-care-homes
#15
Steve Iliffe, Pandora Wright, Ruth Law, Andrew Rogerson, Laura Cole, Jill Manthorpe, Mashur Khan
No abstract text is available yet for this article.
November 1, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28974643/perceived-satisfaction-with-long-term-oxygen-delivery-devices-affects-perceived-mobility-and-quality-of-life-of-oxygen-dependent-individuals-with-copd
#16
Constance C Mussa, Laura Tonyan, Yi-Fan Chen, David Vines
BACKGROUND: Although routine physical activity for individuals with COPD is recommended, there are inherent limitations of available oxygen delivery devices that may result in hypoxemia during activity. Changes in Medicare laws have resulted in an increased use of oxygen cylinders and a reduction in the use of liquid oxygen devices. The aim of this survey was to assess the impact of perceived satisfaction with various oxygen delivery devices on perceived mobility and quality of life (QOL) of oxygen-dependent subjects with COPD...
October 3, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28971857/health-system-and-law-enforcement-synergies-for-injury-surveillance-control-and-prevention-a-scoping-review
#17
REVIEW
Sara F Jacoby, Laura M Mercer Kollar, Greg Ridgeway, Steven A Sumner
BACKGROUND: Healthcare providers and law enforcement (LE) officers are among the most common first responders to injuring events. Despite frequent interface between the health system (HS) and LE sectors, the published evidence that supports their collaboration in injury surveillance, control and prevention has not been comprehensively reviewed. METHODS: We conducted a scoping review of literature published from 1990 to 2016 that focused on local and regional HS and LE collaborations in injury surveillance, control and prevention...
September 29, 2017: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/28960316/genome-wide-association-study-and-meta-analysis-in-northern-european-populations-replicate-multiple-colorectal-cancer-risk-loci
#18
Tomas Tanskanen, Linda van den Berg, Niko Välimäki, Mervi Aavikko, Eivind Ness-Jensen, Kristian Hveem, Yvonne Wettergren, Elinor Bexe Lindskog, Neeme Tõnisson, Andres Metspalu, Kaisa Silander, Giulia Orlando, Philip J Law, Sari Tuupanen, Alexandra E Gylfe, Ulrika A Hänninen, Tatiana Cajuso, Johanna Kondelin, Antti-Pekka Sarin, Eero Pukkala, Pekka Jousilahti, Veikko Salomaa, Samuli Ripatti, Aarno Palotie, Heikki Järvinen, Laura Renkonen-Sinisalo, Anna Lepistö, Jan Böhm, Jukka-Pekka Mecklin, Nada A Al-Tassan, Claire Palles, Lynn Martin, Ella Barclay, Albert Tenesa, Susan M Farrington, Maria N Timofeeva, Brian F Meyer, Salma M Wakil, Harry Campbell, Christopher G Smith, Shelley Idziaszczyk, Tim S Maughan, Richard Kaplan, Rachel Kerr, David Kerr, Daniel D Buchanan, Aung K Win, John Hopper, Mark A Jenkins, Polly A Newcomb, Steve Gallinger, David Conti, Fredrick R Schumacher, Graham Casey, Jeremy P Cheadle, Malcolm G Dunlop, Ian P Tomlinson, Richard S Houlston, Kimmo Palin, Lauri A Aaltonen
Genome-wide association studies have been successful in elucidating the genetic basis of colorectal cancer (CRC), but there remains unexplained variability in genetic risk. To identify new risk variants and to confirm reported associations, we conducted a genome-wide association study in 1,701 CRC cases and 14,082 cancer-free controls from the Finnish population. A total of 9,068,015 genetic variants were imputed and tested, and 30 promising variants were studied in additional 11,647 cases and 12,356 controls of European ancestry...
September 28, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28918717/ecological-origins-of-freedom-pathogens-heat-stress-and-frontier-topography-predict-more-vertical-but-less-horizontal-governmental-restriction
#19
Lucian Gideon Conway, Kate Bongard, Victoria Plaut, Laura Janelle Gornick, Daniel P Dodds, Thomas Giresi, Roger G Tweed, Meredith A Repke, Shannon C Houck
What kinds of physical environments make for free societies? The present research investigates the effect of three different types of ecological stressors (climate stress, pathogen stress, and frontier topography) on two measurements of governmental restriction: Vertical restriction involves select persons imposing asymmetrical laws on others, while horizontal restriction involves laws that restrict most members of a society equally. Investigation 1 validates our measurements of vertical and horizontal restriction...
October 2017: Personality & Social Psychology Bulletin
https://www.readbyqxmd.com/read/28863522/non-equilibrium-surface-tension-of-the-vapour-liquid-interface-of-active-lennard-jones-particles
#20
Siddharth Paliwal, Vasileios Prymidis, Laura Filion, Marjolein Dijkstra
We study a three-dimensional system of self-propelled Brownian particles interacting via the Lennard-Jones potential. Using Brownian dynamics simulations in an elongated simulation box, we investigate the steady states of vapour-liquid phase coexistence of active Lennard-Jones particles with planar interfaces. We measure the normal and tangential components of the pressure tensor along the direction perpendicular to the interface and verify mechanical equilibrium of the two coexisting phases. In addition, we determine the non-equilibrium interfacial tension by integrating the difference of the normal and tangential components of the pressure tensor and show that the surface tension as a function of strength of particle attractions is well fitted by simple power laws...
August 28, 2017: Journal of Chemical Physics
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