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Anosognosia

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https://www.readbyqxmd.com/read/28421896/anosognosia-and-its-relation-to-psychiatric-symptoms-in-early-onset-alzheimer-disease
#1
Bora Yoon, Yong S Shim, Yun Jeong Hong, Seong Hye Choi, Hee Kyung Park, Sun Ah Park, Jee Hyang Jeong, Soo Jin Yoon, Dong-Won Yang
BACKGROUND: We investigated differences in the prevalence of anosognosia and neuropsychiatric symptoms (NPSs) characteristics according to disease severity in patients with early-onset Alzheimer disease (EOAD). METHODS: We recruited 616 patients with EOAD. We subdivided participants into 2 groups based on the presence or absence of anosognosia and then again by Clinical Dementia Rating (CDR) scale. We compared the differences in the Neuropsychiatric Inventory (NPI) scores according to anosognosia and disease severity...
May 2017: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/28385579/memory-self-awareness-in-the-preclinical-and-prodromal-stages-of-alzheimer-s-disease
#2
Patrizia Vannini, Rebecca Amariglio, Bernard Hanseeuw, Keith A Johnson, Donald G McLaren, Jasmeer Chhatwal, Alvaro Pascual-Leone, Dorene Rentz, Reisa A Sperling
While loss of insight of cognitive deficits, anosognosia, is a common symptom in Alzheimer's disease dementia, there is a lack of consensus regarding the presence of altered awareness of memory function in the preclinical and prodromal stages of the disease. Paradoxically, very early in the Alzheimer's disease process, individuals may experience heightened awareness of memory changes before any objective cognitive deficits can be detected, here referred to as hypernosognosia. In contrast, awareness of memory dysfunction shown by individuals with mild cognitive impairment (MCI) is very variable, ranging from marked concern to severe lack of insight...
April 3, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28365036/toward-a-useful-standard-for-hospitalizing-pretrial-jail-detainees
#3
REVIEW
Alan R Felthous
Severely mentally ill jail detainees require an adequate spectrum of mental health services during detainment. For some this means a limited period of treatment in a mental hospital, just as some mentally ill individuals in the community occasionally require hospital treatment. Unfortunately, this appropriate level of treatment is often denied or neglected for jail detainees with adverse consequences for them. Among the reasons for this neglect, may be standards for hospital transfer that are no longer practical and can be easily skirted by policymakers and administrators with little interest in ensuring this level of care for mentally ill jail inmates...
March 29, 2017: International Journal of Law and Psychiatry
https://www.readbyqxmd.com/read/28357826/anton-s-syndrome-as-a-presentation-of-decompression-illness
#4
Charles Paul Azzopardi, Lyubisa Matity, Stephen Muscat
We present a case of a patient with Anton's syndrome due to decompression illness (DCI) after recreational scuba diving. Visual anosognosia, or denial of loss of vision, which is associated with lack of awareness regarding visual loss in the setting of cortical blindness, is known as Anton's syndrome (also termed Anton-Babinski syndrome). Our patient presented with progressive neurological DCI treated with repeated recompression. The anosogosia resolved after 48 h. Subsequent echocardiography revealed a persistent (patent) foramen ovale...
March 2017: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://www.readbyqxmd.com/read/28283961/integrating-the-constructs-of-anosognosia-and-metacognition-a-review-of-recent-findings-in-dementia
#5
REVIEW
Preeti Sunderaraman, Stephanie Cosentino
The current review integrates recent findings regarding the construct of self-awareness in dementia from both clinical and cognitive perspectives. We present the predominant theoretical models of awareness and summarize both traditional and emerging approaches to assessing awareness from clinical and meta-cognitive perspectives. In this review, we focus primarily on findings from recent studies in anosognosia and meta-cognition in the context of neurodegenerative disease with special emphasis on Alzheimer's disease and frontotemporal dementia...
March 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/27909421/metacognition-and-perspective-taking-in-alzheimer-s-disease-a-mini-review
#6
REVIEW
Elodie Bertrand, Jesus Landeira-Fernandez, Daniel C Mograbi
Metacognition refers to the monitoring and regulation of cognitive processes and its impairment can lead to a lack of self-awareness of deficits, or anosognosia. In the context of different neurological and psychiatric disorders (e.g., traumatic brain injury, dementia, and schizophrenia), studies have shown that patients who present impairments in metacognitive abilities may be able to recognize such difficulties in others and in themselves when exposed to material in a third-person perspective. Considering that metacognitive impairments are an important characteristic of dementia, especially in Alzheimer's Disease (AD), studies of the relationship between metacognition and perspective-taking may be relevant to improve the quality of life of people with dementia...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27886007/sleep-wake-profile-in-dementia-with-lewy-bodies-alzheimer-s-disease-and-normal-aging
#7
Annachiara Cagnin, Federica Fragiacomo, Giulia Camporese, Matteo Turco, Cinzia Bussè, Mario Ermani, Sara Montagnese
BACKGROUND: Alterations of the sleep-wake cycle are common features of neurodegenerative dementia. OBJECTIVES: To study differences in sleep-wake profiles in dementia with Lewy bodies (DLB), Alzheimer's disease (AD), and healthy controls. METHODS: 30 DLB and 32 AD patients, and 33 healthy elderly participants were studied. Patients were evaluated for global cognitive impairment, extrapyramidal signs, fluctuations of attention, and behavioral disorders...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27858712/self-consciousness-deficits-in-alzheimer-s-disease-and-frontotemporal-dementia
#8
Eva Ma Arroyo-Anlló, Adèle Turpin Bouston, Marie-Noëlle Fargeau, Begoña Orgaz Baz, Roger Gil
Self-consciousness (SC) is multifaceted and considered to be the consciousness of one's own mental states. The main aim of this paper is to compare SC in patients with Alzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD). Three groups (control and patient groups) of 23 subjects each were assessed using an SC questionnaire. Both types of dementia clearly induce an alteration of SC. The bvFTD group showed a greater impairment in SC than the AD and control groups. The SC score was strongly associated with frontal functions...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27819840/repressive-coping-does-not-contribute-to-anosognosia-in-first-diagnosis-patients-with-alzheimer-disease
#9
Sandra Verhülsdonk, Christian Lange-Asschenfeldt, Barbara Höft, Holger Schwender, Tillmann Supprian, Florence Hellen, Elke Kalbe
Anosognosia is common in patients with Alzheimer disease (AD) even in early stages. Although neural correlates and the impact of cognitive dysfunctions have been described, possible psychodynamic processes such as a repressive coping style as described in other illnesses, have not been examined. Our study aimed to examine possible psychological influence factors on illness perception embracing a repressive coping style and cognitive functions in AD patients in the diagnostic process. Fifty-four subjects with mild AD diagnosed in our memory clinic were enrolled...
November 4, 2016: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27780496/cognitive-and-anatomical-correlates-of-anosognosia-in-amnestic-mild-cognitive-impairment-and-early-stage-alzheimer-s-disease
#10
Gulben Senturk, Basar Bilgic, Ali Bilgin Arslan, Ali Bayram, Hasmet Hanagasi, Hakan Gurvit, Murat Emre
BACKGROUND: Anosognosia is a common feature in Alzheimer's disease (AD). The brain substrates of anosognosia are not fully understood, and less is known about the cognitive substrates of anosognosia in prodromal and early stages of AD. METHODS: Fourty-seven patients with amnestic-type mild cognitive impairment (aMCI) (n = 26) and early-stage AD (n = 21) were included, and Clinical Insight Rating Scale and Anosognosia Questionnaire for Dementia (AQ-D) were used to assess anosognosia...
October 26, 2016: International Psychogeriatrics
https://www.readbyqxmd.com/read/27779298/-the-prefrontal-symptoms-inventory-psi-in-acquired-brain-injury-agreement-between-the-scores-of-patients-relatives-and-professionals
#11
E Huertas-Hoyas, E J Pedrero-Perez, M Martinez-Campos, M Laselle-Lopez
INTRODUCTION: The use of self-reports about symptoms of malfunctioning in daily life derived from functional deficits of a prefrontal origin has become widespread in clinical practice, since they allow incremental ecological validity to be added to other specific tests. Yet it remains to be determined whether self-assessment is sufficient on its own or if the participation of an external evaluator would be preferable. SUBJECTS AND METHODS: The Prefrontal Symptoms Inventory (PSI) was administered to 115 subjects being treated for a range of brain pathologies...
November 1, 2016: Revista de Neurologia
https://www.readbyqxmd.com/read/27767990/the-proactive-self-in-space-how%C3%A2-egocentric-and-allocentric-spatial-impairments-contribute-to-anosognosia-in%C3%A2-alzheimer-s-disease
#12
Silvia Serino, Giuseppe Riva
In addition to impairments in episodic and spatial memory, anosognosia (i.e., loss of awareness of the deficient aspect of own cognitive functioning) may be considered an important cognitive marker of Alzheimer's disease (AD). However, although a growing body of interesting models have been proposed to explain this early symptom, what is still missing is a unifying framework of all the characteristic signs occurring in patients with AD that may guide the search for its causal neuropathological process and, ultimately, the etiological process...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27750070/examination-of-the-metacognitive-errors-that-contribute-to-anosognosia-in-alzheimer-s-disease
#13
Stephanie Cosentino, Carolyn Zhu, Elodie Bertrand, Janet Metcalfe, Sarah Janicki, Sarah Cines
Disordered awareness of memory loss (i.e., anosognosia) is a frequent and clinically relevant symptom of Alzheimer's disease (AD). The metacognitive errors which characterize anosognosia in AD, however, have not been fully articulated. The current study examined metamemory performance as a function of clinically defined awareness groups using different task conditions to examine the extent to which specific metacognitive deficits (i.e., detecting, integrating, or being explicitly aware of errors) contribute to anosognosia in AD (n = 49)...
November 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/27742371/leucoencephalopathy-following-abuse-of-sniffed-heroin
#14
Romain Lefaucheur, Axel Lebas, Emmanuel Gérardin, Lou Grangeon, Ozlem Ozkul-Wermester, Carole Aubier-Girard, Olivier Martinaud, David Maltête
A 29-year-old man was admitted for acute cognitive impairment. Three weeks earlier, he had been admitted for coma due to sniffed heroin abuse responsive to naloxone infusion. At admission, the patient presented with apraxia, severe memory impairment and anosognosia. Brain MRI revealed symmetric hyperintensities of supratentorial white matter, sparing brainstem and cerebellum, on FLAIR and B1000 sequences. Four months later, repeated neuropsychological assessment revealed dramatic improvement of global cognitive functions...
January 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/27697664/mood-congruent-recollection-and-anosognosia-in%C3%A2-alzheimer-s-disease
#15
Elodie Bertrand, Marcia C N Dourado, Jerson Laks, Robin G Morris, Jesus Landeira-Fernandez, Daniel C Mograbi
The aim of the study was to investigate experimentally the impact of current mood state on anosognosia or awareness of symptoms in AD patients, in which mood state was manipulated by giving tasks that were either easy (success condition) or very difficult (failure condition). Twenty-two patients with mild to moderate AD participated. Four success-failure manipulation (SFM) computerized tasks were used as mood induction procedures, two based on reaction time tasks and the other on memory tasks. Level of awareness and the current mood state were assessed before and after each task, using a modified version of the Anosognosia Questionnaire for Dementia and a self-reported questionnaire respectively...
September 13, 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/27677926/mnemonic-anosognosia-in-alzheimer-s-disease-is-caused-by-a-failure-to-transfer-online-evaluations-of-performance-evidence-from-memory-training-programs
#16
Ana Rita Silva, Maria Salomé Pinho, Luís Macedo, Céline Souchay, Christopher Moulin
INTRODUCTION: There is a debate about the ability of patients with Alzheimer's disease to build an up-to-date representation of their memory function, which has been termed mnemonic anosognosia. This form of anosognosia is typified by accurate online evaluations of performance, but dysfunctional or outmoded representations of function more generally. METHOD: We tested whether people with Alzheimer's disease could adapt or change their representations of memory performance across three different six-week memory training programs using global judgements of learning...
September 27, 2016: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/27636844/consequences-of-anosognosia-on-the-cost-of-caregivers-care-in-alzheimer-s-disease
#17
Oriol Turró-Garriga, Josep Garre-Olmo, Ramon Reñé-Ramírez, Laia Calvó-Perxas, Jordi Gascón-Bayarri, Josep-Lluís Conde-Sala
BACKGROUND: Anosognosia is common in patients with Alzheimer's disease (AD) and it is frequently related to an increase in time of care demand. OBJECTIVE: The aim of the study was to examine the effect of anosognosia on the total costs of informal care in patients with AD. METHODS: This was a prospective longitudinal study with community-dwelling AD patients. Anosognosia, time of informal care, and the use of support services (e.g., day care centers) were recorded at baseline and after 24 months...
October 18, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27622655/the-struggle-for-schizophrenia-treatment-a-case-study
#18
Maria Kozlowski-Gibson
Individual of legal age with schizophrenia presenting anosognosia was abandoned, as a result of a court decision. Close family members were not allowed to provide medical follow-up, treatment, protection regarding his vulnerability, and preserve the dignity of their loved one. The issue was the court's prioritization of the autonomy of the individual over his mental health status. The purpose of this case study was to identify the pitfalls of a court case seeking medical follow-up and treatment for a family member with schizophrenia and anosognosia...
September 2016: International Journal of Law and Psychiatry
https://www.readbyqxmd.com/read/27494375/motor-versus-body-awareness-voxel-based-lesion-analysis-in-anosognosia-for-hemiplegia-and-somatoparaphrenia-following-right-hemisphere-stroke
#19
Valentina Moro, Simone Pernigo, Manos Tsakiris, Renato Avesani, Nicola M J Edelstyn, Paul M Jenkinson, Aikaterini Fotopoulou
Anosognosia for hemiplegia (AHP) is informative about the neurocognitive basis of motor awareness. However, it is frequently associated with concomitant symptoms, such as hemispatial neglect and disturbances in the sense of body ownership (DSO). Although double dissociations between these symptoms have been reported, there is ongoing debate about whether they are manifestations of independent abnormalities, or a single neurocognitive deficit. We aimed to investigate the specificity of lesions associated with AHP by surpassing four, existing methodological limitations: (a) recruit a relatively large sample of patients (total N = 70) in a multi-centre study; (b) identify lesions associated with AHP in grey and white matter using voxel-based methods; (c) take into account the duration of AHP and concomitant neglect symptoms; and (d) compare lesions against a control hemiplegic group, patients suffering from AHP and DSO, and a few, rare patients with selective DSO...
October 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/27484245/space-related-confabulations-after-right-hemisphere-damage
#20
REVIEW
Paolo Bartolomeo, Stefania de Vito, Tal Seidel Malkinson
Confabulations usually refer to memory distortions, characterized by the production of verbal statements or actions that are inconsistent with the patient's history and present situation. However, behavioral patterns reminiscent of memory confabulations can also occur in patients with right hemisphere damage, in relation to their personal, peripersonal or extrapersonal space. Thus, such patients may be unaware of their left hemiplegia and confabulate about it (anosognosia), deny the ownership of their left limbs (somatoparaphrenia), insult and hit them (misoplegia), or experience a "third", supernumerary left limb...
February 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
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