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https://www.readbyqxmd.com/read/29028874/impaired-self-awareness-of-motor-disturbances-in-parkinson-s-disease
#1
Franziska Maier, George P Prigatano
Traditionally, anosognosia for cognitive or motor impairments in patients with Parkinson's disease (PD) was viewed as unlikely unless the patient was demented. More recent research has suggested that a portion of non-demented PD patients (30%-50%) in fact have impaired subjective awareness (ISA) of their motor impairments (ISAm). This empirical finding has implications for the clinical neuropsychological examination of PD patients and raises theoretical questions relevant to the broader study of anosognosia seen in other patient groups...
September 28, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29022655/anosognosia-is-an-independent-predictor-of-conversion-from-mild-cognitive-impairment-to-alzheimer-s-disease-and-is-associated-with-reduced-brain-metabolism
#2
Philip Gerretsen, Jun Ku Chung, Parita Shah, Eric Plitman, Yusuke Iwata, Fernando Caravaggio, Shinichiro Nakajima, Bruce G Pollock, Ariel Graff-Guerrero
OBJECTIVE: Anosognosia, or impaired illness awareness, is a common feature of Alzheimer's disease (AD) and less so of mild cognitive impairment (MCI). Importantly, anosognosia negatively influences clinical outcomes for patients and their caregivers and may predict the conversion from MCI to AD. This study aimed to examine (1) the relationship between brain glucose metabolism as measured by fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) and anosognosia in patients with MCI and AD and (2) the predictive utility of anosognosia in patients with MCI for later conversion to AD, even when controlling for other factors, including gender, education, apolipoprotein E ε4 carrier status, dementia severity, and cognitive dysfunction...
October 10, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28991661/behavioral-and-affective-features-of-amyotrophic-lateral-sclerosis-patients
#3
Yasuyuki Ohta, Kota Sato, Mami Takemoto, Yoshiaki Takahashi, Ryuta Morihara, Yumiko Nakano, Keiichiro Tsunoda, Emi Nomura, Nozomi Hishikawa, Toru Yamashita, Koji Abe
Evaluating the cognitive and behavioral features in amyotrophic lateral sclerosis (ALS) patients is important for therapy and care. Fifty-seven ALS, 5 ALS with the behavioral variant of frontotemporal dementia (FTD) (ALS-FTD), 12 FTD patients, and 35 control subjects were evaluated by 10 different tests for cognitive and behavioral (mini-mental state examination (MMSE), Hasegawa dementia rating scale - revised (HDS-R), frontal assessment battery (FAB), Montreal cognitive assessment (MoCA), ALS-frontotemporal dementia-Questionnaire (ALS-FTD-Q), and anosognosia scale), affective (depression, apathy, and behavioral and psychological symptoms of dementia (BPSD)), and activities of daily living (ADL) assessments...
October 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28843132/henry-where-have-you-lost-your-self
#4
Nathalie Philippi, Daniel Roquet, Hédi Ben Malek, Vincent Noblet, Anne Botzung, Benjamin Cretin, Frédéric Blanc
The Self is a complex construct encompassing distinct components, including episodic and semantic autobiographical memory, the Self-concept, and the subjective sense of Self, which highest level consists of Self-awareness. The neuro-anatomical correlates are complex, and it is debated as to whether a common region could support these different components of the Self, with a particular interest for the cortical midline structures and the medial prefrontal cortex (MPFC). Alzheimer's disease (AD) constitutes an interesting model for the study of Self as autobiographical memory typically deteriorates as the disease progresses...
July 14, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28840743/self-awareness-for-memory-impairment-in-amnestic-mild-cognitive-impairment-a-longitudinal-study
#5
Ilaria Cova, Giulia Grande, Valentina Cucumo, Roberta Ghiretti, Laura Maggiore, Daniela Galimberti, Elio Scarpini, Claudio Mariani, Simone Pomati
AIM: To assess memory impairment insight as a predictor of dementia and Alzheimer's disease (AD) in amnestic mild cognitive impairment (MCI). METHODS: To verify whether the awareness of memory impairment assessed by Geriatric Depression Scale (GDS) was associated with the risk of progression to dementia and AD in a cohort of MCI, we used a Cox regression model adjusted for age, sex, education, subtypes of amnestic MCI, Mini-Mental State Examination, Cumulative Illness Rating Scale severity index, and apolipoprotein E genotype...
January 1, 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28836490/unawareness-for-motor-impairment-and-distorted-perception-of-task-difficulty
#6
Gianna Cocchini, Nicoletta Beschin, Sergio Della Sala
OBJECTIVES: Anosognosia for motor impairment is a complex syndrome that can manifest itself under different forms, guiding patients' behavior and task decisions. However, current diagnostic tools tend to evaluate only more explicit aspects of anosognosia (asking the patients about their motor abilities) and fail to address more subtle features of awareness. We have developed a new assessment measure, the ECT (Errand Choice Test), where patients are asked to judge task difficulty rather than estimate their own impairment...
August 24, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28806707/deviant-functional-activation-and-connectivity-of-the-right-insula-are-associated-with-lack-of-awareness-of-episodic-memory-impairment-in-nonamnesic-alcoholism
#7
Anne-Pascale Le Berre, Eva M Müller-Oehring, Tilman Schulte, Matthew R Serventi, Adolf Pfefferbaum, Edith V Sullivan
A disorder of metamemory, expressed as unawareness of mnemonic ability, is typically associated with the profound amnesia of Korsakoff's Syndrome (KS). A similar but less severe type of limited awareness can also occur in non-KS alcoholism and is observed as an impairment in generating Feeling-of-Knowing (FOK) predictions about future recognition performance. We previously found that FOK accuracy was selectively related to volumes of the insula in alcoholics involved in the present study. Unknown, however, are the neural substrates of unawareness of memory impairment in alcoholism...
October 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28740390/brain-regions-associated-with-anosognosia-for-memory-disturbance-in-alzheimer-s-disease-a-magnetic-resonance-imaging-study
#8
Hiroshi Fujimoto, Teruyuki Matsuoka, Yuka Kato, Keisuke Shibata, Kaeko Nakamura, Kei Yamada, Jin Narumoto
BACKGROUND AND OBJECTIVE: Patients with Alzheimer's disease (AD) are frequently unaware of their cognitive symptoms and medical diagnosis. The term "anosognosia" is used to indicate a general lack of awareness of one's disease or disorder. The neural substrate underlying anosognosia in AD is unclear. Since anosognosia for memory disturbance might be an initial sign of AD, it is important to determine the neural correlates. This study was designed to investigate the characteristics and neural correlates of anosognosia for memory disturbance in patients with mild AD...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28699151/-emotion-recognition-rehabilitation-combined-with-cognitive-stimulation-for-people-with-alzheimer-s-disease-efficacy-for-cognition-and-functional-aspects
#9
J A Garcia-Casal, M Goni-Imizcoz, M V Perea-Bartolome, C Garcia-Moja, S Calvo-Simal, F Cardelle-Garcia, M Franco-Martin
INTRODUCTION: The ability to recognize facial emotional expression is essential for social interactions and adapting to the environment. Emotion recognition is impaired in people with Alzheimer's disease (AD), thus rehabilitation of these skills has the potential to elicit significant benefits. AIM: To assess the efficacy of a combined treatment of rehabilitation of emotion recognition (RER) and cognitive stimulation (CS) for people with AD, due to its potential implications for more effective psychosocial interventions...
August 1, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28671134/low-cognitive-awareness-but-not-complaint-is-a-good-marker-of-preclinical-alzheimer-s-disease
#10
Federica Cacciamani, Caroline Tandetnik, Geoffroy Gagliardi, Hugo Bertin, Marie-Odile Habert, Harald Hampel, Laurie Boukadida, Marie Révillon, Stéphane Epelbaum, Bruno Dubois
BACKGROUND: Subjective cognitive decline (SCD) may result from many conditions, including Alzheimer's disease (AD). OBJECTIVE: In this study, we searched for a specific pattern of SCD in asymptomatic individuals at risk for AD. METHODS: Cognitively normal older adults (N = 318) reporting SCD and their informants were enrolled in the INSIGHT-PreAD cohort. We examined the relationship between six SCD measures and both cognitive scores and AD neuroimaging markers (amyloid burden, hippocampal atrophy and brain hypometabolism)...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28616381/anosognosia-for-memory-deficits-in-mild-cognitive-impairment-insight-into-the-neural-mechanism-using-functional-and-molecular-imaging
#11
Patrizia Vannini, Bernard Hanseeuw, Catherine E Munro, Rebecca E Amariglio, Gad A Marshall, Dorene M Rentz, Alvaro Pascual-Leone, Keith A Johnson, Reisa A Sperling
Anosognosia, or loss of insight of memory deficits, is a common and striking symptom in Alzheimer's disease (AD). Previous findings in AD dementia patients suggest that anosognosia is due to both functional metabolic changes within cortical midline structures involved in self-referential processes, as well as functional disconnection between these regions. The present study aims to extend these findings by investigating the neural correlates of anosognosia in the prodromal stage of AD. Here, we used regional brain metabolism (resting state 18-F fluorodeoxyglucose positron emission tomography (FDG-PET)) to unravel the metabolic correlates of anosognosia in subjects with amnestic mild cognitive impairment (aMCI) and subsequently resting state functional magnetic resonance imaging (rs-fMRI) to investigate the intrinsic connectivity disruption between brain regions...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28501758/modulating-anosognosia-for-hemiplegia-the-role-of-dangerous-actions-in-emergent-awareness
#12
Daniela D'Imperio, Cristina Bulgarelli, Sara Bertagnoli, Renato Avesani, Valentina Moro
Anosognosia for hemiplegia is a lack of awareness of motor deficits following a right hemisphere lesion. Residual forms of awareness co-occur with an explicit denial of hemiplegia. The term emergent awareness refers to a condition in which awareness of motor deficits is reported verbally during the actual performance of an action involving the affected body part. In this study, two tasks were used to explore the potential effects of i) attempting actions which are impossible for sufferers of hemiplegia and ii) attempting actions which are potentially dangerous...
April 21, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28484905/historical-perspectives-on-ancient-greek-derived-a-prefixed-nomenclature-for-acquired-neurocognitive-impairment
#13
REVIEW
Philip Gerard Gasquoine
Distinct forms of acquired neurocognitive impairment are often described by "a" prefixed terms that derive from ancient Greek (and in one case Latin). Two modern English language neurological and neuropsychological reference books were searched to identify 17 such terms in contemporary usage: amnesia, akinesia, ataxia, aphasia, agraphia, anosmia, apraxia, athetosis, ageusia, achromatopsia, agnosia, alexia, amusia, anomia, anarthria, anosognosia, and acalculia. These were traced to their initial association with acquired neurocognitive impairment in German, English, and French language medical publications from the late 18th, 19th, and early 20th centuries (1770 through 1920)...
May 8, 2017: Neuropsychology Review
https://www.readbyqxmd.com/read/28436930/a-framework-for-ethical-decision-making-in-the-rehabilitation-of-patients-with-anosognosia
#14
Anna Rita Egbert
Currently, the number of patients diagnosed with impaired self-awareness of their own deficits after brain injury-anosognosia-is increasing. One reason is a growing understanding of this multifaceted phenomenon. Another is the development and accessibility of alternative measurements that allow more detailed diagnoses. Anosognosia can adversely affect successful rehabilitation, as often patients lack confidence in the need for treatment. Planning such treatment can become a complex process full of ethical dilemmas...
2017: Journal of Clinical Ethics
https://www.readbyqxmd.com/read/28421896/anosognosia-and-its-relation-to-psychiatric-symptoms-in-early-onset-alzheimer-disease
#15
MULTICENTER STUDY
Bora Yoon, Yong S Shim, Yun Jeong Hong, Seong Hye Choi, Hee Kyung Park, Sun Ah Park, Jee Hyang Jeong, Soo Jin Yoon, Dong-Won Yang
BACKGROUND: We investigated differences in the prevalence of anosognosia and neuropsychiatric symptoms (NPSs) characteristics according to disease severity in patients with early-onset Alzheimer disease (EOAD). METHODS: We recruited 616 patients with EOAD. We subdivided participants into 2 groups based on the presence or absence of anosognosia and then again by Clinical Dementia Rating (CDR) scale. We compared the differences in the Neuropsychiatric Inventory (NPI) scores according to anosognosia and disease severity...
May 2017: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/28385579/memory-self-awareness-in-the-preclinical-and-prodromal-stages-of-alzheimer-s-disease
#16
Patrizia Vannini, Rebecca Amariglio, Bernard Hanseeuw, Keith A Johnson, Donald G McLaren, Jasmeer Chhatwal, Alvaro Pascual-Leone, Dorene Rentz, Reisa A Sperling
While loss of insight of cognitive deficits, anosognosia, is a common symptom in Alzheimer's disease dementia, there is a lack of consensus regarding the presence of altered awareness of memory function in the preclinical and prodromal stages of the disease. Paradoxically, very early in the Alzheimer's disease process, individuals may experience heightened awareness of memory changes before any objective cognitive deficits can be detected, here referred to as hypernosognosia. In contrast, awareness of memory dysfunction shown by individuals with mild cognitive impairment (MCI) is very variable, ranging from marked concern to severe lack of insight...
May 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28365036/toward-a-useful-standard-for-hospitalizing-pretrial-jail-detainees
#17
REVIEW
Alan R Felthous
Severely mentally ill jail detainees require an adequate spectrum of mental health services during detainment. For some this means a limited period of treatment in a mental hospital, just as some mentally ill individuals in the community occasionally require hospital treatment. Unfortunately, this appropriate level of treatment is often denied or neglected for jail detainees with adverse consequences for them. Among the reasons for this neglect, may be standards for hospital transfer that are no longer practical and can be easily skirted by policymakers and administrators with little interest in ensuring this level of care for mentally ill jail inmates...
March 29, 2017: International Journal of Law and Psychiatry
https://www.readbyqxmd.com/read/28357826/anton-s-syndrome-as-a-presentation-of-decompression-illness
#18
Charles Paul Azzopardi, Lyubisa Matity, Stephen Muscat
We present a case of a patient with Anton's syndrome due to decompression illness (DCI) after recreational scuba diving. Visual anosognosia, or denial of loss of vision, which is associated with lack of awareness regarding visual loss in the setting of cortical blindness, is known as Anton's syndrome (also termed Anton-Babinski syndrome). Our patient presented with progressive neurological DCI treated with repeated recompression. The anosogosia resolved after 48 h. Subsequent echocardiography revealed a persistent (patent) foramen ovale...
March 2017: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://www.readbyqxmd.com/read/28283961/integrating-the-constructs-of-anosognosia-and-metacognition-a-review-of-recent-findings-in-dementia
#19
REVIEW
Preeti Sunderaraman, Stephanie Cosentino
The current review integrates recent findings regarding the construct of self-awareness in dementia from both clinical and cognitive perspectives. We present the predominant theoretical models of awareness and summarize both traditional and emerging approaches to assessing awareness from clinical and meta-cognitive perspectives. In this review, we focus primarily on findings from recent studies in anosognosia and meta-cognition in the context of neurodegenerative disease with special emphasis on Alzheimer's disease and frontotemporal dementia...
March 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/27909421/metacognition-and-perspective-taking-in-alzheimer-s-disease-a-mini-review
#20
REVIEW
Elodie Bertrand, Jesus Landeira-Fernandez, Daniel C Mograbi
Metacognition refers to the monitoring and regulation of cognitive processes and its impairment can lead to a lack of self-awareness of deficits, or anosognosia. In the context of different neurological and psychiatric disorders (e.g., traumatic brain injury, dementia, and schizophrenia), studies have shown that patients who present impairments in metacognitive abilities may be able to recognize such difficulties in others and in themselves when exposed to material in a third-person perspective. Considering that metacognitive impairments are an important characteristic of dementia, especially in Alzheimer's Disease (AD), studies of the relationship between metacognition and perspective-taking may be relevant to improve the quality of life of people with dementia...
2016: Frontiers in Psychology
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