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Anosognosia

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https://www.readbyqxmd.com/read/27909421/metacognition-and-perspective-taking-in-alzheimer-s-disease-a-mini-review
#1
REVIEW
Elodie Bertrand, Jesus Landeira-Fernandez, Daniel C Mograbi
Metacognition refers to the monitoring and regulation of cognitive processes and its impairment can lead to a lack of self-awareness of deficits, or anosognosia. In the context of different neurological and psychiatric disorders (e.g., traumatic brain injury, dementia, and schizophrenia), studies have shown that patients who present impairments in metacognitive abilities may be able to recognize such difficulties in others and in themselves when exposed to material in a third-person perspective. Considering that metacognitive impairments are an important characteristic of dementia, especially in Alzheimer's Disease (AD), studies of the relationship between metacognition and perspective-taking may be relevant to improve the quality of life of people with dementia...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27886007/sleep-wake-profile-in-dementia-with-lewy-bodies-alzheimer-s-disease-and-normal-aging
#2
Annachiara Cagnin, Federica Fragiacomo, Giulia Camporese, Matteo Turco, Cinzia Bussè, Mario Ermani, Sara Montagnese
BACKGROUND: Alterations of the sleep-wake cycle are common features of neurodegenerative dementia. OBJECTIVES: To study differences in sleep-wake profiles in dementia with Lewy bodies (DLB), Alzheimer's disease (AD), and healthy controls. METHODS: 30 DLB and 32 AD patients, and 33 healthy elderly participants were studied. Patients were evaluated for global cognitive impairment, extrapyramidal signs, fluctuations of attention, and behavioral disorders...
November 19, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27858712/self-consciousness-deficits-in-alzheimer-s-disease-and-frontotemporal-dementia
#3
Eva Ma Arroyo-Anlló, Adèle Turpin Boustonb, Marie-Noëlle Fargeau, Begoña Orgaz Baz, Roger Gil
Self-consciousness (SC) is multifaceted and considered to be the consciousness of one's own mental states. The main aim of this paper is to compare SC in patients with Alzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD). Three groups (control and patient groups) of 23 subjects each were assessed using an SC questionnaire. Both types of dementia clearly induce an alteration of SC. The bvFTD group showed a greater impairment in SC than the AD and control groups. The SC score was strongly associated with frontal functions...
November 14, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27819840/repressive-coping-does-not-contribute-to-anosognosia-in-first-diagnosis-patients-with-alzheimer-disease
#4
Sandra Verhülsdonk, Christian Lange-Asschenfeldt, Barbara Höft, Holger Schwender, Tillmann Supprian, Florence Hellen, Elke Kalbe
Anosognosia is common in patients with Alzheimer disease (AD) even in early stages. Although neural correlates and the impact of cognitive dysfunctions have been described, possible psychodynamic processes such as a repressive coping style as described in other illnesses, have not been examined. Our study aimed to examine possible psychological influence factors on illness perception embracing a repressive coping style and cognitive functions in AD patients in the diagnostic process. Fifty-four subjects with mild AD diagnosed in our memory clinic were enrolled...
November 4, 2016: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27780496/cognitive-and-anatomical-correlates-of-anosognosia-in-amnestic-mild-cognitive-impairment-and-early-stage-alzheimer-s-disease
#5
Gulben Senturk, Basar Bilgic, Ali Bilgin Arslan, Ali Bayram, Hasmet Hanagasi, Hakan Gurvit, Murat Emre
BACKGROUND: Anosognosia is a common feature in Alzheimer's disease (AD). The brain substrates of anosognosia are not fully understood, and less is known about the cognitive substrates of anosognosia in prodromal and early stages of AD. METHODS: Fourty-seven patients with amnestic-type mild cognitive impairment (aMCI) (n = 26) and early-stage AD (n = 21) were included, and Clinical Insight Rating Scale and Anosognosia Questionnaire for Dementia (AQ-D) were used to assess anosognosia...
October 26, 2016: International Psychogeriatrics
https://www.readbyqxmd.com/read/27779298/-the-prefrontal-symptoms-inventory-psi-in-acquired-brain-injury-agreement-between-the-scores-of-patients-relatives-and-professionals
#6
E Huertas-Hoyas, E J Pedrero-Perez, M Martinez-Campos, M Laselle-Lopez
INTRODUCTION: The use of self-reports about symptoms of malfunctioning in daily life derived from functional deficits of a prefrontal origin has become widespread in clinical practice, since they allow incremental ecological validity to be added to other specific tests. Yet it remains to be determined whether self-assessment is sufficient on its own or if the participation of an external evaluator would be preferable. SUBJECTS AND METHODS: The Prefrontal Symptoms Inventory (PSI) was administered to 115 subjects being treated for a range of brain pathologies...
November 1, 2016: Revista de Neurologia
https://www.readbyqxmd.com/read/27767990/the-proactive-self-in-space-how%C3%A2-egocentric-and-allocentric-spatial-impairments-contribute-to-anosognosia-in%C3%A2-alzheimer-s-disease
#7
Silvia Serino, Giuseppe Riva
In addition to impairments in episodic and spatial memory, anosognosia (i.e., loss of awareness of the deficient aspect of own cognitive functioning) may be considered an important cognitive marker of Alzheimer's disease (AD). However, although a growing body of interesting models have been proposed to explain this early symptom, what is still missing is a unifying framework of all the characteristic signs occurring in patients with AD that may guide the search for its causal neuropathological process and, ultimately, the etiological process...
October 20, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27750070/examination-of-the-metacognitive-errors-that-contribute-to-anosognosia-in-alzheimer-s-disease
#8
Stephanie Cosentino, Carolyn Zhu, Elodie Bertrand, Janet Metcalfe, Sarah Janicki, Sarah Cines
Disordered awareness of memory loss (i.e., anosognosia) is a frequent and clinically relevant symptom of Alzheimer's disease (AD). The metacognitive errors which characterize anosognosia in AD, however, have not been fully articulated. The current study examined metamemory performance as a function of clinically defined awareness groups using different task conditions to examine the extent to which specific metacognitive deficits (i.e., detecting, integrating, or being explicitly aware of errors) contribute to anosognosia in AD (n = 49)...
November 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/27742371/leucoencephalopathy-following-abuse-of-sniffed-heroin
#9
Romain Lefaucheur, Axel Lebas, Emmanuel Gérardin, Lou Grangeon, Ozlem Ozkul-Wermester, Carole Aubier-Girard, Olivier Martinaud, David Maltête
A 29-year-old man was admitted for acute cognitive impairment. Three weeks earlier, he had been admitted for coma due to sniffed heroin abuse responsive to naloxone infusion. At admission, the patient presented with apraxia, severe memory impairment and anosognosia. Brain MRI revealed symmetric hyperintensities of supratentorial white matter, sparing brainstem and cerebellum, on FLAIR and B1000 sequences. Four months later, repeated neuropsychological assessment revealed dramatic improvement of global cognitive functions...
October 11, 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/27697664/mood-congruent-recollection-and-anosognosia-in%C3%A2-alzheimer-s-disease
#10
Elodie Bertrand, Marcia C N Dourado, Jerson Laks, Robin G Morris, Jesus Landeira-Fernandez, Daniel C Mograbi
The aim of the study was to investigate experimentally the impact of current mood state on anosognosia or awareness of symptoms in AD patients, in which mood state was manipulated by giving tasks that were either easy (success condition) or very difficult (failure condition). Twenty-two patients with mild to moderate AD participated. Four success-failure manipulation (SFM) computerized tasks were used as mood induction procedures, two based on reaction time tasks and the other on memory tasks. Level of awareness and the current mood state were assessed before and after each task, using a modified version of the Anosognosia Questionnaire for Dementia and a self-reported questionnaire respectively...
September 13, 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/27677926/mnemonic-anosognosia-in-alzheimer-s-disease-is-caused-by-a-failure-to-transfer-online-evaluations-of-performance-evidence-from-memory-training-programs
#11
Ana Rita Silva, Maria Salomé Pinho, Luís Macedo, Céline Souchay, Christopher Moulin
INTRODUCTION: There is a debate about the ability of patients with Alzheimer's disease to build an up-to-date representation of their memory function, which has been termed mnemonic anosognosia. This form of anosognosia is typified by accurate online evaluations of performance, but dysfunctional or outmoded representations of function more generally. METHOD: We tested whether people with Alzheimer's disease could adapt or change their representations of memory performance across three different six-week memory training programs using global judgements of learning...
September 27, 2016: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/27636844/consequences-of-anosognosia-on-the-cost-of-caregivers-care-in-alzheimer-s-disease
#12
Oriol Turró-Garriga, Josep Garre-Olmo, Ramon Reñé-Ramírez, Laia Calvó-Perxas, Jordi Gascón-Bayarri, Josep-Lluís Conde-Sala
BACKGROUND: Anosognosia is common in patients with Alzheimer's disease (AD) and it is frequently related to an increase in time of care demand. OBJECTIVE: The aim of the study was to examine the effect of anosognosia on the total costs of informal care in patients with AD. METHODS: This was a prospective longitudinal study with community-dwelling AD patients. Anosognosia, time of informal care, and the use of support services (e.g., day care centers) were recorded at baseline and after 24 months...
October 18, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27622655/the-struggle-for-schizophrenia-treatment-a-case-study
#13
Maria Kozlowski-Gibson
Individual of legal age with schizophrenia presenting anosognosia was abandoned, as a result of a court decision. Close family members were not allowed to provide medical follow-up, treatment, protection regarding his vulnerability, and preserve the dignity of their loved one. The issue was the court's prioritization of the autonomy of the individual over his mental health status. The purpose of this case study was to identify the pitfalls of a court case seeking medical follow-up and treatment for a family member with schizophrenia and anosognosia...
September 2016: International Journal of Law and Psychiatry
https://www.readbyqxmd.com/read/27494375/motor-versus-body-awareness-voxel-based-lesion-analysis-in-anosognosia-for-hemiplegia-and-somatoparaphrenia-following-right-hemisphere-stroke
#14
Valentina Moro, Simone Pernigo, Manos Tsakiris, Renato Avesani, Nicola M J Edelstyn, Paul M Jenkinson, Aikaterini Fotopoulou
Anosognosia for hemiplegia (AHP) is informative about the neurocognitive basis of motor awareness. However, it is frequently associated with concomitant symptoms, such as hemispatial neglect and disturbances in the sense of body ownership (DSO). Although double dissociations between these symptoms have been reported, there is ongoing debate about whether they are manifestations of independent abnormalities, or a single neurocognitive deficit. We aimed to investigate the specificity of lesions associated with AHP by surpassing four, existing methodological limitations: (a) recruit a relatively large sample of patients (total N = 70) in a multi-centre study; (b) identify lesions associated with AHP in grey and white matter using voxel-based methods; (c) take into account the duration of AHP and concomitant neglect symptoms; and (d) compare lesions against a control hemiplegic group, patients suffering from AHP and DSO, and a few, rare patients with selective DSO...
October 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/27484245/space-related-confabulations-after-right-hemisphere-damage
#15
Paolo Bartolomeo, Stefania de Vito, Tal Seidel Malkinson
Confabulations usually refer to memory distortions, characterized by the production of verbal statements or actions that are inconsistent with the patient's history and present situation. However, behavioral patterns reminiscent of memory confabulations can also occur in patients with right hemisphere damage, in relation to their personal, peripersonal or extrapersonal space. Thus, such patients may be unaware of their left hemiplegia and confabulate about it (anosognosia), deny the ownership of their left limbs (somatoparaphrenia), insult and hit them (misoplegia), or experience a "third", supernumerary left limb...
July 15, 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/27458368/decreased-self-appraisal-accuracy-on-cognitive-tests-of-executive-functioning-is-a-predictor-of-decline-in-mild-cognitive-impairment
#16
Carole S Scherling, Sarah E Wilkins, Jessica Zakrezewski, Joel H Kramer, Bruce L Miller, Michael W Weiner, Howard J Rosen
OBJECTIVE: Mild cognitive impairment (MCI) in older individuals is associated with increased risk of progression to dementia. The factors predicting progression are not yet well established, yet cognitive performance, particularly for memory, is known to be important. Anosognosia, meaning lack of awareness of one's impaired function, is commonly reported in dementia and is often also a feature of MCI, but its association with risk of progression is not well understood. In particular, self-appraisal measures provide an autonomous measure of insight abilities, without the need of an informant...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27447979/anosognosia-for-memory-impairment-in-addiction-insights-from-neuroimaging-and-neuropsychological-assessment-of-metamemory
#17
REVIEW
Anne-Pascale Le Berre, Edith V Sullivan
In addiction, notably Alcohol Use Disorder (AUD), patients often have a tendency to fail to acknowledge the reality of the disease and to minimize the physical, psychological, and social difficulties attendant to chronic alcohol consumption. This lack of awareness can reduce the chances of initiating and maintaining sobriety. Presented here is a model focusing on compromised awareness in individuals with AUD of mild to moderate cognitive deficits, in particular, for episodic memory impairment-the ability to learn new information, such as recent personal experiences...
December 2016: Neuropsychology Review
https://www.readbyqxmd.com/read/27438597/anosognosia-in-dementia
#18
REVIEW
Robert S Wilson, Joel Sytsma, Lisa L Barnes, Patricia A Boyle
Progressive decline in memory (and other functions) is the defining feature of late-life dementia but affected individuals are often unaware of this impairment. This article reviews recent research on anosognosia in dementia, including methods of assessing anosognosia, its prevalence and developmental course in dementia, its occurrence in different forms of dementia, neuroimaging findings, and hypothesized component mechanisms. The results suggest that anosognosia is eventually exhibited by nearly all persons with dementia...
September 2016: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/27341471/behavioural-and-neuroimaging-correlates-of-impaired-self-awareness-of-hypo-and-hyperkinesia-in-parkinson-s-disease
#19
Franziska Maier, Kim L Williamson, Masoud Tahmasian, Luisa Rochhausen, Anna L Ellereit, George P Prigatano, Lutz Kracht, Chris C Tang, Damian M Herz, Gereon R Fink, Lars Timmermann, Carsten Eggers
INTRODUCTION: Anosognosia or impaired self-awareness of motor symptoms (ISAm) has been rarely investigated in Parkinson's disease (PD). We here studied the relationship between ISAm during periods with and without dopaminergic medication (ON- and OFF-state), and clinical, neuropsychological, and neuroimaging data to further elucidate behavioural aspects and the neurobiological underpinnings of ISAm. METHODS: Thirty-one right-handed, non-demented, non-depressed PD patients were included...
September 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/27332067/presence-or-absence-of-cognitive-complaints-in-parkinson-s-disease-mood-disorder-or-anosognosia
#20
Pollyanna Celso F Castro, Camila Catherine Aquino, André C Felício, Flávia Doná, Leonardo M I Medeiros, Sônia M C A Silva, Henrique Ballalai Ferraz, Paulo Henrique F Bertolucci, Vanderci Borges
We intended to evaluate whether non-demented Parkinsons's disease (PD) patients, with or without subjective cognitive complaint, demonstrate differences between them and in comparison to controls concerning cognitive performance and mood. We evaluated 77 subjects between 30 and 70 years, divided as follows: PD without cognitive complaints (n = 31), PD with cognitive complaints (n = 21) and controls (n = 25). We applied the following tests: SCOPA-Cog, Trail Making Test-B, Phonemic Fluency, Clock Drawing Test, Boston Naming Test, Neuropsychiatric Inventory, Hospital Anxiety and Depression Scale (HADS) and Beck Depression Inventory...
June 2016: Arquivos de Neuro-psiquiatria
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