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Anosognosia

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https://www.readbyqxmd.com/read/29666594/association-of-lower-spiritual-well-being-social-support-self-esteem-subjective-well-being-optimism-and-hope-scores-with-mild-cognitive-impairment-and-mild-dementia
#1
Sabrina B Dos Santos, Gabrielli P Rocha, Liana L Fernandez, Analuiza C de Padua, Caroline T Reppold
Introduction: Positive psychology (PP) constructs contribute significantly to a better quality of life for people with various diseases. There are still few studies that have evaluated the evolution of these aspects during the progression of dementia. Objective: To compare the scores for self-esteem, life satisfaction, affect, spirituality, hope, optimism and perceived support network between elderly people with mild cognitive impairment (MCI), mild dementia and moderate dementia and control group. Methods: Cross-sectional study...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29648845/online-and-offline-awareness-deficits-anosognosia-for-spatial-neglect
#2
Peii Chen, Joan Toglia
PURPOSE/OBJECTIVE: Anosognosia for spatial neglect (ASN) can be offline or online. Offline ASN is general unawareness of having experienced spatial deficits. Online ASN is an awareness deficit of underestimating spatial difficulties that likely to occur in an upcoming task (anticipatory ASN) or have just occurred during the task (emergent ASN). We explored the relationships among spatial neglect, offline ASN, anticipatory ASN, and emergent ASN. Research Method/Design: Forty-four survivors of stroke answered questionnaires assessing offline and online self-awareness of spatial problems...
April 12, 2018: Rehabilitation Psychology
https://www.readbyqxmd.com/read/29528693/interaction-between-memory-impairment-and-depressive-symptoms-can-exacerbate-anosognosia-a-comparison-of-alzheimer-s-disease-with-mild-cognitive-impairment
#3
Hikaru Oba, Teruyuki Matsuoka, Ayu Imai, Hiroshi Fujimoto, Yuka Kato, Keisuke Shibata, Kaeko Nakamura, Jin Narumoto
OBJECTIVE: To investigate the effects of interactions between memory impairment, depressive symptoms, and anosognosia. METHODS: Anosognosia for memory impairment was assessed in 118 patients with Alzheimer's disease (AD), 47 patients with mild cognitive impairment (MCI), and 17 non-diagnosed controls (NC) using a questionnaire and evaluation of the anosognosia score as the discrepancy between ratings of the patient and a relative. Demographic characteristics, such as the relationship of the patient with the relative and the activities of daily living (ADL) were evaluated...
March 12, 2018: Aging & Mental Health
https://www.readbyqxmd.com/read/29518705/cross-domain-self-monitoring-in-anosognosia-for-memory-loss-in-alzheimer-s-disease
#4
Silvia Chapman, Leigh E Colvin, Matti Vuorre, Gianna Cocchini, Janet Metcalfe, Edward D Huey, Stephanie Cosentino
Anosognosia for memory loss is a common feature of Alzheimer's disease (AD). Recent theories have proposed that anosognosia, a disruption in awareness at a global level, may reflect specific deficits in self-monitoring, or local awareness. Though anosognosia for memory loss has been shown to relate to memory self-monitoring, it is not clear if it relates to self-monitoring deficits in other domains (i.e., motor). The current study examined this question by analyzing the relationship between anosognosia for memory loss, memory monitoring, and motor monitoring in 35 individuals with mild to moderate AD...
February 8, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29444971/anosognosia-predicts-default-mode-network-hypometabolism-and-clinical-progression-to-dementia
#5
Joseph Therriault, Kok Pin Ng, Tharick A Pascoal, Sulantha Mathotaarachchi, Min Su Kang, Hanne Struyfs, Monica Shin, Andrea L Benedet, Ishan C Walpola, Vasavan Nair, Serge Gauthier, Pedro Rosa-Neto
OBJECTIVE: To identify the pathophysiologic mechanisms and clinical significance of anosognosia for cognitive decline in mild cognitive impairment. METHODS: We stratified 468 patients with amnestic mild cognitive impairment into intact and impaired awareness groups, determined by the discrepancy between the patient and the informant score on the Everyday Cognition questionnaire. Voxel-based linear regression models evaluated the associations between self-awareness status and baseline β-amyloid load, measured by [ 18 F]florbetapir, and the relationships between awareness status and regional brain glucose metabolism measured by [ 18 F]fluorodeoxyglucose at baseline and at 24-month follow-up...
February 14, 2018: Neurology
https://www.readbyqxmd.com/read/29409154/anosognosia-in-mild-alzheimer-s-disease-is-correlated-with-not-only-neural-dysfunction-but-also-compensation
#6
Kenji Tagai, Shunichiro Shinagawa, Hidehiro Kada, Keisuke Inamura, Tomoyuki Nagata, Kazuhiko Nakayama
BACKGROUND: Anosognosia in Alzheimer's disease (AD) is a complicated, non-unitary phenomenon. In a clinical setting, patients with mild AD often preserve their awareness partially. We hypothesized that compensation, as well as neural dysfunction, could be correlated with anosognosia in mild AD. METHODS: The severity of anosognosia was evaluated using the Anosognosia Questionnaire for Dementia in 37 subjects with mild AD or mild cognitive impairment due to AD. The subjects also underwent single-photon emission computed tomography with N-isopropyl-p-[123 I]iodoamphetamine...
March 2018: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
https://www.readbyqxmd.com/read/29262415/anorexia-nervosa-and-first-person-perspective-altruism-family-system-and-body-experience
#7
Jérôme Englebert, Valérie Follet, Caroline Valentiny
Based on the case study of Jeanne, the objective of this article is to study patterns of specific subjectivity in anorexic subjects. We seek to identify, in a first-person perspective, the core vulnerability features of anorexic existence, beyond the dimension of food alone. The identification of a psychopathological structure results in a better understanding of Jeanne's clinical situation and helps formulate psychotherapeutic and prophylactic recommendations. We suggest that so-called "denial" is a psychological mechanism that should be reconsidered...
2018: Psychopathology
https://www.readbyqxmd.com/read/29251546/examining-anosognosia-of-neglect
#8
Emily S Grattan, Elizabeth R Skidmore, Michelle L Woodbury
Unilateral neglect (neglect) and anosognosia often co-occur post stroke. It is unknown whether anosognosia of neglect varies for different types of daily activities. The objective is to examine the frequency of anosognosia of neglect for items on the Catherine Bergego Scale (CBS) and to determine the level of agreement between participant/assessor item ratings and total scores. Secondary analysis of data was carried out. We conducted descriptive analyses and interrater reliability analyses (Cohen's kappa) to determine the level of agreement between assessor and participant item ratings...
April 2018: OTJR: Occupation, Participation and Health
https://www.readbyqxmd.com/read/29145178/minor-hemisphere-major-syndromes
#9
Antonio Carota, Julien Bogousslavsky
A right "minor hemisphere" does not exist as the right hemisphere is dominant for awareness (nosognosia), spatial attention, emotional regulation, facial and voice expressions, visual recognition, and topographical orientation. Without the right hemisphere, the world would be flat, deprived of general and spatial attentions, pointing preferentially to the right side of the space, lacking visual experiences and emotions, exhibiting diminished awareness of the self and environment. Clinical-related syndromes of the right hemisphere are unilateral spatial neglect, object and face visual agnosia, the anosognosia for hemiparesis and/or hemianopia, misidentification syndromes, mania, and other obsessions for the food and the body...
2018: Frontiers of Neurology and Neuroscience
https://www.readbyqxmd.com/read/29122459/resolution-of-anton-babinski-syndrome-after-systemic-thrombolysis-and-mechanical-thrombectomy-with-a-stentriever
#10
Giuseppe Leone, Sergio Nappini, Andrea Wlderk, Antonio Laiso, Maria Lamassa, Patrizia Nencini, Salvatore Mangiafico, Nicola Limbucci
Anton-Babinski syndrome is a rare neuropsychiatric syndrome characterized by bilateral cortical blindness and anosognosia with visual confabulation. We present the case of a patient presenting with occlusion of both posterior cerebral arteries (PCA), with Anton-Babinski syndrome, completely solved after combined systemic thrombolysis and mechanical thrombectomy with a stent-retriever.
February 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29102412/anosognosia-denial-of-illness-and-the-right-hemisphere-dominance-for-emotions-some-historical-and-clinical-notes
#11
REVIEW
Guido Gainotti
Poor disease awareness ('anosognosia') is often observed in patients with various disabilities caused by brain damage. The lack of disease awareness can be due to the disruption of specific cognitive mechanisms and the development of psychodynamic mechanisms of denial. The aim of this paper is to review how these phenomena were discovered and evolved over time and to consider the relationships between them and the right hemisphere dominance for emotions. It is not clear whether the term 'anosognosia' refers to a basic mechanism that can explain similar awareness defects in different behavioural domains or whether it must be viewed as a multifaceted phenomenon in which both the disruption of cognitive or sensorimotor mechanisms and the emergence of motivational factors can play different roles in various forms of disease unawareness and in different kinds of 'anosognosic' patients...
October 25, 2017: Consciousness and Cognition
https://www.readbyqxmd.com/read/29089874/mistakes-too-few-to-mention-impaired-self-conscious-emotional-processing-of-errors-in-the-behavioral-variant-of-frontotemporal-dementia
#12
Carole S Scherling, Jessica Zakrzewski, Samir Datta, Robert W Levenson, Arthur P Shimamura, Virginia E Sturm, Bruce L Miller, Howard J Rosen
Anosognosia, or lack of awareness of one's deficits, is a core feature of the behavioral variant of frontotemporal dementia (bvFTD). We hypothesized that this deficit has its origins in failed emotional processing of errors. We studied autonomic and facial emotional reactivity to errors in patients with bvFTD ( n = 17), Alzheimer's disease (AD, n = 20), and healthy controls (HC, n = 35) during performance of a timed two-alternative-choice button press task. Performance-related behavioral responses to errors were quantified using rates of error correction and post-error slowing of reaction times...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29028874/impaired-self-awareness-of-motor-disturbances-in-parkinson-s-disease
#13
Franziska Maier, George P Prigatano
Traditionally, anosognosia for cognitive or motor impairments in patients with Parkinson's disease (PD) was viewed as unlikely unless the patient was demented. More recent research has suggested that a portion of non-demented PD patients (30%-50%) in fact have impaired subjective awareness (ISA) of their motor impairments (ISAm). This empirical finding has implications for the clinical neuropsychological examination of PD patients and raises theoretical questions relevant to the broader study of anosognosia seen in other patient groups...
November 1, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29022655/anosognosia-is-an-independent-predictor-of-conversion-from-mild-cognitive-impairment-to-alzheimer-s-disease-and-is-associated-with-reduced-brain-metabolism
#14
Philip Gerretsen, Jun Ku Chung, Parita Shah, Eric Plitman, Yusuke Iwata, Fernando Caravaggio, Shinichiro Nakajima, Bruce G Pollock, Ariel Graff-Guerrero
OBJECTIVE: Anosognosia, or impaired illness awareness, is a common feature of Alzheimer's disease (AD) and less so of mild cognitive impairment (MCI). Importantly, anosognosia negatively influences clinical outcomes for patients and their caregivers and may predict the conversion from MCI to AD. This study aimed to examine (1) the relationship between brain glucose metabolism as measured by fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) and anosognosia in patients with MCI and AD and (2) the predictive utility of anosognosia in patients with MCI for later conversion to AD, even when controlling for other factors, including gender, education, apolipoprotein E ε4 carrier status, dementia severity, and cognitive dysfunction...
November 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28991661/behavioral-and-affective-features-of-amyotrophic-lateral-sclerosis-patients
#15
Yasuyuki Ohta, Kota Sato, Mami Takemoto, Yoshiaki Takahashi, Ryuta Morihara, Yumiko Nakano, Keiichiro Tsunoda, Emi Nomura, Nozomi Hishikawa, Toru Yamashita, Koji Abe
Evaluating the cognitive and behavioral features in amyotrophic lateral sclerosis (ALS) patients is important for therapy and care. Fifty-seven ALS, 5 ALS with the behavioral variant of frontotemporal dementia (FTD) (ALS-FTD), 12 FTD patients, and 35 control subjects were evaluated by 10 different tests for cognitive and behavioral (mini-mental state examination (MMSE), Hasegawa dementia rating scale - revised (HDS-R), frontal assessment battery (FAB), Montreal cognitive assessment (MoCA), ALS-frontotemporal dementia-Questionnaire (ALS-FTD-Q), and anosognosia scale), affective (depression, apathy, and behavioral and psychological symptoms of dementia (BPSD)), and activities of daily living (ADL) assessments...
October 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28843132/henry-where-have-you-lost-your-self
#16
Nathalie Philippi, Daniel Roquet, Hédi Ben Malek, Vincent Noblet, Anne Botzung, Benjamin Cretin, Frédéric Blanc
The Self is a complex construct encompassing distinct components, including episodic and semantic autobiographical memory, the Self-concept, and the subjective sense of Self, which highest level consists of Self-awareness. The neuro-anatomical correlates are complex, and it is debated as to whether a common region could support these different components of the Self, with a particular interest for the cortical midline structures and the medial prefrontal cortex (MPFC). Alzheimer's disease (AD) constitutes an interesting model for the study of Self as autobiographical memory typically deteriorates as the disease progresses...
July 14, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28840743/self-awareness-for-memory-impairment-in-amnestic-mild-cognitive-impairment-a-longitudinal-study
#17
Ilaria Cova, Giulia Grande, Valentina Cucumo, Roberta Ghiretti, Laura Maggiore, Daniela Galimberti, Elio Scarpini, Claudio Mariani, Simone Pomati
AIM: To assess memory impairment insight as a predictor of dementia and Alzheimer's disease (AD) in amnestic mild cognitive impairment (MCI). METHODS: To verify whether the awareness of memory impairment assessed by Geriatric Depression Scale (GDS) was associated with the risk of progression to dementia and AD in a cohort of MCI, we used a Cox regression model adjusted for age, sex, education, subtypes of amnestic MCI, Mini-Mental State Examination, Cumulative Illness Rating Scale severity index, and apolipoprotein E genotype...
January 1, 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28836490/unawareness-for-motor-impairment-and-distorted-perception-of-task-difficulty
#18
Gianna Cocchini, Nicoletta Beschin, Sergio Della Sala
OBJECTIVES: Anosognosia for motor impairment is a complex syndrome that can manifest itself under different forms, guiding patients' behavior and task decisions. However, current diagnostic tools tend to evaluate only more explicit aspects of anosognosia (asking the patients about their motor abilities) and fail to address more subtle features of awareness. We have developed a new assessment measure, the ECT (Errand Choice Test), where patients are asked to judge task difficulty rather than estimate their own impairment...
January 2018: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28806707/deviant-functional-activation-and-connectivity-of-the-right-insula-are-associated-with-lack-of-awareness-of-episodic-memory-impairment-in-nonamnesic-alcoholism
#19
Anne-Pascale Le Berre, Eva M Müller-Oehring, Tilman Schulte, Matthew R Serventi, Adolf Pfefferbaum, Edith V Sullivan
A disorder of metamemory, expressed as unawareness of mnemonic ability, is typically associated with the profound amnesia of Korsakoff's Syndrome (KS). A similar but less severe type of limited awareness can also occur in non-KS alcoholism and is observed as an impairment in generating Feeling-of-Knowing (FOK) predictions about future recognition performance. We previously found that FOK accuracy was selectively related to volumes of the insula in alcoholics involved in the present study. Unknown, however, are the neural substrates of unawareness of memory impairment in alcoholism...
October 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28740390/brain-regions-associated-with-anosognosia-for-memory-disturbance-in-alzheimer-s-disease-a-magnetic-resonance-imaging-study
#20
Hiroshi Fujimoto, Teruyuki Matsuoka, Yuka Kato, Keisuke Shibata, Kaeko Nakamura, Kei Yamada, Jin Narumoto
BACKGROUND AND OBJECTIVE: Patients with Alzheimer's disease (AD) are frequently unaware of their cognitive symptoms and medical diagnosis. The term "anosognosia" is used to indicate a general lack of awareness of one's disease or disorder. The neural substrate underlying anosognosia in AD is unclear. Since anosognosia for memory disturbance might be an initial sign of AD, it is important to determine the neural correlates. This study was designed to investigate the characteristics and neural correlates of anosognosia for memory disturbance in patients with mild AD...
2017: Neuropsychiatric Disease and Treatment
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