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https://www.readbyqxmd.com/read/28723598/effects-of-tumor-necrosis-factor-blocker-on-salicylate-induced-tinnitus-in-mice
#1
Juen-Haur Hwang, David Chang-Wei Huang, Yin-Chang Lu, Wei-Shiung Yang, Tien-Chen Liu
OBJECTIVE: Neuroinflammation is considered a novel mechanism for acute tinnitus. Here, we investigated the effects of a tumor necrosis factor (TNF) blocker on the gene expression of inflammatory-cytokine in the cochlea in a tinnitus animal model. METHODS: Enbrel® (30 mg/kg, intraperitoneally (i.p.)) were administrated to the mice with the salicylate induced tinnitus for 3 days. Tinnitus score and mRNA expression levels of TNFR1, TNFR2, and N-methyl-d-aspartate receptor subunit 2B (NR2B) and its downstream regulatory element antagonist modulator (DREAM) in the cochlea of mice were measured and compared to the control...
June 1, 2017: International Tinnitus Journal
https://www.readbyqxmd.com/read/28723508/targeting-adaptive-pathways-in-metastatic-treatment-resistant-prostate-cancer-update-on-the-stand-up-2-cancer-prostate-cancer-foundation-supported-west-coast-prostate-cancer-dream-team
#2
Rahul Aggarwal, Tomasz M Beer, Martin Gleave, Joshua M Stuart, Matthew Rettig, Christopher P Evans, Jack Youngren, Joshi J Alumkal, Jiaoti Huang, George Thomas, Owen Witte, Eric J Small
The Stand Up 2 Cancer/Prostate Cancer Foundation-funded West Coast Dream Team project is a prospective multi-institutional study focused on acquiring metastatic castration-resistant prostate cancer (mCRPC) biopsy tissue at the time of resistance to abiraterone or enzalutamide. It is the first large-scale study designed to analyze mCRPC tissue specifically in this patient population. Study accrual is on target, with 261 out of a planned 300 metastatic tumor biopsies performed by August 2016. Paired biopsies have been completed in 42 patients, with paired genomic data before and after therapy obtained in 26 cases...
December 2016: European Urology Focus
https://www.readbyqxmd.com/read/28715599/dreamlike-events-are-correlated-with-the-length-of-sleep-mentation-reports
#3
N Rosenlicht, C Primich, J R McQuaid, T Maloney, I Feinberg
We investigated the relationship between length and dreamlike quality in sleep mentation reports. Reports were obtained by waking subjects at sleep onset (SO) and at 5 and 10 minutes into the second (REMP2) and fourth REM periods (REMP4). Reports were recorded, transcribed, and scored blindly for total word count (TWC) and dreamlike quality as measured by a composite dream scale score (CDS). Dreamlike quality was strongly correlated with TWC; both CDS and TWC scores increased across successively later awakenings...
July 1, 2017: Archives Italiennes de Biologie
https://www.readbyqxmd.com/read/28712461/2017-remington-honor-medal-address-blessings-and-dreams
#4
EDITORIAL
Daniel A Hussar
No abstract text is available yet for this article.
July 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28708847/attitudes-and-perceptions-towards-novel-objective-measures-of-arv-based-vaginal-ring-use-results-from-a-global-stakeholder-survey
#5
Randy M Stalter, Jenae Tharaldson, Derek H Owen, Eunice Okumu, Thomas Moench, Natasha Mack, Elizabeth E Tolley, Kathleen M MacQueen
Results of recent microbicide and pre-exposure prophylaxis clinical trials have shown adherence to be a significant challenge with new HIV prevention technologies. As the vaginal ring containing dapivirine moves into two open label follow-on studies (HOPE/MTN-025 and DREAM) and other antiretroviral-based and multi-purpose prevention technology ring products advance through the development pipeline, there is a need for more accurate and reliable measures of adherence to microbicide ring products. We previously conducted a comprehensive landscape analysis to identify new technologies that could be applied to adherence measurement of vaginal rings containing antiretrovirals...
2017: PloS One
https://www.readbyqxmd.com/read/28708013/psychometric-evaluation-of-an-abbreviated-version-of-the-intragroup-marginalization-inventory
#6
Jasmin Llamas, Louisa M Holmes, Nadra E Lisha, Pamela M Ling
Tobacco and marijuana use among U.S. young adults is a top public health concern, and racial/ethnic minorities may be at particular risk. Past research examining cultural variables has focused on the individual in relation to the mainstream U.S. culture; however, an individual can also experience within-group stress, or intragroup marginalization. We used the 2014 San Francisco Bay Area Young Adult Health Survey to validate an abbreviated measure of intragroup marginalization and identify associations between intragroup marginalization and tobacco and marijuana use among ethnic minority young adults (N = 1,058)...
July 14, 2017: Journal of Ethnicity in Substance Abuse
https://www.readbyqxmd.com/read/28701602/to-evaluate-dexmedetomidine-as-an-additive-to-propofol-for-sedation-for-elective-cardioversion-in-a-cardiac-intensive-care-unit-a-double-blind-randomized-controlled-trial
#7
Tanveer Singh Kundra, Parminder Kaur, P S Nagaraja, N Manjunatha
INTRODUCTION: Propofol may lead to patient recall and discomfort when used for sedation in elective cardioversion. The aim of the present study was to evaluate dexmedetomidine as an additive to propofol for sedation in elective cardioversion. MATERIALS AND METHODS: A total of 500 patients undergoing elective cardioversion were randomized into Group 1 (n = 250) and Group 2 (n = 250) on the basis of computer-generated randomization table. Patients in Group 1 were given dexmedetomidine (1 mcg/kg) over 10 min before giving propofol (1 mg/kg), while patients in Group 2 were given only propofol (1 mg/kg)...
July 2017: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/28696031/a-biotechnologist-s-dream-doubly-green-processes
#8
Ana Segura
No abstract text is available yet for this article.
July 11, 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/28695616/keeping-the-aqueous-polar-organometallic-chemistry-dream-alive-unprecedented-water-catalyzed-nucleophilic-additions-of-highly-polar-organometallic-compounds-to-imines-and-nitriles
#9
Giuseppe Dilauro, Marzia Dell'Aera, Paola Vitale, Vito Capriati, Filippo Maria Perna
In contrast to classic protocols carried out under inert atmospheres with dry volatile organic solvents and often low temperatures, we report that the addition of highly polar organometallic compounds to non-activated imines and nitriles proceeds quickly, efficiently, and chemoselectively with a broad range of substrates at room temperature and under air with water as the only reaction medium, providing secondary amines and tertiary carbinamines with yields up to >99%. The significant solvent D/H isotope effect observed for the on-water nucleophilic additions of organolithiums to imines suggests that the on-water catalysis arises from proton transfer across the organic-water interface...
July 11, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28676120/the-dream-team-for-sexual-reproductive-maternal-newborn-and-adolescent-health-an-adjusted-service-target-model-to-estimate-the-ideal-mix-of-health-care-professionals-to-cover-population-need
#10
Petra Ten Hoope-Bender, Andrea Nove, Laura Sochas, Zoë Matthews, Caroline S E Homer, Francisco Pozo-Martin
BACKGROUND: A competent, enabled and efficiently deployed health workforce is crucial to the achievement of the health-related sustainable development goals (SDGs). Methods for workforce planning have tended to focus on 'one size fits all' benchmarks, but because populations vary in terms of their demography (e.g. fertility rates) and epidemiology (e.g. HIV prevalence), the level of need for sexual, reproductive, maternal, newborn and adolescent health (SRMNAH) workers also varies, as does the ideal composition of the workforce...
July 4, 2017: Human Resources for Health
https://www.readbyqxmd.com/read/28673212/awareness-during-general-anaesthesia-in-the-first-4-000-incidents-reported-to-webairs
#11
K Leslie, M D Culwick, H Reynolds, J A Hannam, A F Merry
The aim of this study was to analyse the incidents related to awareness during general anaesthesia in the first 4,000 cases reported to webAIRS-an anaesthetic incident reporting system established in Australia and New Zealand in 2009. Included incidents were those in which the reporter selected "neurological" as the main category and "awareness/dreaming/nightmares" as a subcategory, those where the narrative report included the word "awareness" and those identified by the authors as possibly relevant to awareness...
July 2017: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/28649389/cases-of-acute-mercury-poisoning-by-mercury-vapor-exposure-during-the-demolition-of-a-fluorescent-lamp-factory
#12
Sang Yoon Do, Chul Gab Lee, Jae Yoon Kim, Young Hoon Moon, Min Sung Kim, In Ho Bae, Han Soo Song
BACKGROUND: In 2015, workers dismantling a fluorescent lamp factory in Korea were affected by mercury poisoning from exposure to mercury vapor. CASE PRESENTATION: Eighteen out of the 21 workers who participated in the demolition project presented with symptoms of poisoning and, of these, 10 had persistent symptoms even at 18 months after the initial exposure to mercury vapor. Early symptoms of 18 workers included a general skin rash, pruritus, myalgia, sleep disturbance, and cough and sputum production...
2017: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28647955/which-is-crucial-strengthen-the-foundation-or-building-the-dream-house
#13
EDITORIAL
Hiroyuki Isayama, Yousuke Nakai, Toshio Fujisawa
No abstract text is available yet for this article.
July 15, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28647746/the-effects-of-an-internet-based-imagery-rehearsal-intervention-a-randomized-controlled-trial
#14
Annika Gieselmann, Max Böckermann, Marjolijn Sorbi, Reinhard Pietrowsky
BACKGROUND: Nightmares are extremely dysphoric dreams, which are prevalent and associated with psychological strain. This study investigated (a) the efficacy of an internet-based imagery rehearsal therapy (IRT), (b) the role of imagery rescription, and (c) the role of guidance during internet-based IRT. METHODS: A total of 127 patients suffering from mainly idiopathic nightmares were randomly assigned to 1 of 2 IRT internet-based groups (guided IRT; unguided IRT) or to 1 of 2 active control groups (frequency control group; narrative control group)...
2017: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/28646790/the-effects-of-individual-biological-rhythm-differences-on-sleep-quality-daytime-sleepiness-and-dissociative-experiences
#15
Yavuz Selvi, Ali Kandeger, Murat Boysan, Nursel Akbaba, Ayca A Sayin, Emine Tekinarslan, Basak O Koc, Omer F Uygur, Vedat Sar
Individuals who differ markedly by sleep chronotype, i.e., morning-type or evening-type also differ on a number of psychological, behavioral, and biological variables. Among several other psychological functions, dissociation may also lead to disruption and alteration of consciousness, which may facilitate dream-like experiences. Our study was aimed at an inquiry into the effects of individual biological rhythm differences on sleep quality and daytime sleepiness in conjunction with dissociative experiences...
June 17, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28644712/comparative-analysis-of-behavioral-and-transcriptional-variation-underlying-co2-sensory-neuron-function-and-development-in-drosophila
#16
Jia Wern Pan, Joi McLaughlin, Haining Yang, Charles Leo, Paula Rambarat, Sumie Okuwa, Anaïs Monroy-Eklund, Sabrina Clark, Corbin D Jones, Pelin Cayirlioglu Volkan
Carbon dioxide is an important environmental cue for many insects, regulating many behaviors including some that have direct human impacts. To further improve our understanding of how this system varies among closely related insect species, we examined both the behavioral response to CO2 as well as the transcriptional profile of key developmental regulators of CO2 sensory neurons in the olfactory system across the Drosophila genus. We found that CO2 generally evokes repulsive behavior across most of the Drosophilids we examined, but this behavior has been lost or reduced in several lineages...
June 23, 2017: Fly
https://www.readbyqxmd.com/read/28640937/dreams-and-creative-problem-solving
#17
Deirdre Barrett
Dreams have produced art, music, novels, films, mathematical proofs, designs for architecture, telescopes, and computers. Dreaming is essentially our brain thinking in another neurophysiologic state-and therefore it is likely to solve some problems on which our waking minds have become stuck. This neurophysiologic state is characterized by high activity in brain areas associated with imagery, so problems requiring vivid visualization are also more likely to get help from dreaming. This article reviews great historical dreams and modern laboratory research to suggest how dreams can aid creativity and problem-solving...
June 22, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28640285/don-t-let-europe-s-open-science-dream-drift
#18
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
June 20, 2017: Nature
https://www.readbyqxmd.com/read/28638710/nicotine-prevented-learning-and-memory-impairment-in-rem-sleep-deprived-rat-is-modulated-by-dream-protein-in-the-hippocampus
#19
Norlinda Abd Rashid, Hermizi Hapidin, Hasmah Abdullah, Zalina Ismail, Idris Long
INTRODUCTION: REM sleep deprivation is associated with impairment in learning and memory, and nicotine treatment has been shown to attenuate this effect. Recent studies have demonstrated the importance of DREAM protein in learning and memory processes. This study investigates the association of DREAM protein in REM sleep-deprived rats hippocampus upon nicotine treatment. METHODS: Male Sprague Dawley rats were subjected to normal condition, REM sleep deprivation and control wide platform condition for 72 hr...
June 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28638154/-assessment-of-predictive-dermal-exposure-to-chemicals-in-the-work-environment
#20
Agnieszka Jankowska, Sławomir Czerczak, Małgorzata Kupczewska-Dobecka
Assessment of dermal exposure to chemicals in the work environment is problematic, mainly as a result of the lack of measurement data on occupational exposure to chemicals. Due to common prevalence of occupational skin exposure and its health consequences it is necessary to look for efficient solutions allowing for reliable exposure assessment. The aim of the study is to present predictive models used to assess non-measured dermal exposure, as well as to acquaint Polish users with the principles of the selected model functioning...
June 14, 2017: Medycyna Pracy
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