keyword
MENU ▼
Read by QxMD icon Read
search

Dreams

keyword
https://www.readbyqxmd.com/read/27908594/rucaparib-in-relapsed-platinum-sensitive-high-grade-ovarian-carcinoma-ariel2-part-1-an-international-multicentre-open-label-phase-2-trial
#1
Elizabeth M Swisher, Kevin K Lin, Amit M Oza, Clare L Scott, Heidi Giordano, James Sun, Gottfried E Konecny, Robert L Coleman, Anna V Tinker, David M O'Malley, Rebecca S Kristeleit, Ling Ma, Katherine M Bell-McGuinn, James D Brenton, Janiel M Cragun, Ana Oaknin, Isabelle Ray-Coquard, Maria I Harrell, Elaina Mann, Scott H Kaufmann, Anne Floquet, Alexandra Leary, Thomas C Harding, Sandra Goble, Lara Maloney, Jeff Isaacson, Andrew R Allen, Lindsey Rolfe, Roman Yelensky, Mitch Raponi, Iain A McNeish
BACKGROUND: Poly(ADP-ribose) polymerase (PARP) inhibitors have activity in ovarian carcinomas with homologous recombination deficiency. Along with BRCA1 and BRCA2 (BRCA) mutations genomic loss of heterozygosity (LOH) might also represent homologous recombination deficiency. In ARIEL2, we assessed the ability of tumour genomic LOH, quantified with a next-generation sequencing assay, to predict response to rucaparib, an oral PARP inhibitor. METHODS: ARIEL2 is an international, multicentre, two-part, phase 2, open-label study done at 49 hospitals and cancer centres in Australia, Canada, France, Spain, the UK, and the USA...
November 28, 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27903531/dream-plays-an-important-role-in-platelet-activation-and-thrombogenesis
#2
Kyungho Kim, Alan Tseng, Andrew Barazia, Joseph E Italiano, Jaehyung Cho
Downstream regulatory element antagonist modulator (DREAM), a transcriptional repressor, is known to modulate pain responses. However, it is unknown whether DREAM is expressed in anucleate platelets and plays a role in thrombogenesis. By using intravital microscopy with DREAM-null mice and their bone marrow chimeras, we demonstrated that both hematopoietic and non-hematopoietic cell DREAM are required for platelet thrombus formation following laser-induced arteriolar injury. In a FeCl3-induced thrombosis model, we found that compared to WT control and non-hematopoietic DREAM knockout (KO) mice, DREAM KO control and hematopoietic DREAM KO mice showed a significant delay in time to occlusion...
November 30, 2016: Blood
https://www.readbyqxmd.com/read/27903086/the-association-of-smokeless-tobacco-use-and-pack-years-of-smokeless-tobacco-with-age-related-macular-degeneration-in-indian-population
#3
Sangeetha Srinvasan, Gayathri Swaminathan, Vaitheeswaran Kulothungan, Tarun Sharma, Rajiv Raman
PURPOSE: To explore the association of use and the influence of pack-year use of smokeless tobacco versus no use with that of early and late age-related macular degeneration (AMD) in rural and urban south Indian population. We hypothesized that the use and pack-years of use would be significantly associated with both early and late AMD. We therefore sought to examine subjects who gave a history of using smokeless tobacco and we quantified the usage as pack-years, to examine the association with that of early and late AMD...
November 30, 2016: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/27893346/the-preoedipal-and-oedipal-structure-of-termination-an-in-depth-case-study
#4
Trevor Lubbe
Much has been written about the Oedipus complex as a central organizing focus for the understanding of early developmental attainments as well as for the structuring of the personality, but nowhere are triangular forces more vitally active, clinically, than in the termination phase. The decision to end, once agreed upon, typically sets in motion a symmetrical process in which two dynamics occur concurrently. First, what drives the termination is a mourning process in which the primary task is to relinquish the analyst as a transference object and to establish the analyst as an internal object...
December 2016: Psychoanalytic Review
https://www.readbyqxmd.com/read/27892959/novobreak-local-assembly-for-breakpoint-detection-in-cancer-genomes
#5
Zechen Chong, Jue Ruan, Min Gao, Wanding Zhou, Tenghui Chen, Xian Fan, Li Ding, Anna Y Lee, Paul Boutros, Junjie Chen, Ken Chen
We present novoBreak, a genome-wide local assembly algorithm that discovers somatic and germline structural variation breakpoints in whole-genome sequencing data. novoBreak consistently outperformed existing algorithms on real cancer genome data and on synthetic tumors in the ICGC-TCGA DREAM 8.5 Somatic Mutation Calling Challenge primarily because it more effectively utilized reads spanning breakpoints. novoBreak also demonstrated great sensitivity in identifying short insertions and deletions.
November 28, 2016: Nature Methods
https://www.readbyqxmd.com/read/27891640/chasing-the-dream-message-from-the-president
#6
Nan Smith-Blair, Leanne L Lefler
No abstract text is available yet for this article.
November 28, 2016: Research in Nursing & Health
https://www.readbyqxmd.com/read/27882716/toward-a-sociology-of-the-reconciliation-of-conflicting-desires
#7
Susan O'Donnell, David Perley
Desire-based research provides people and communities the opportunity to share their dreams and hopes for a better future. However, conflicting desires are difficult to reconcile. We suggest that sociological research to understand conflicting desires is required to support reconciliation work by Indigenous and non-Indigenous people in Canada. Our contribution begins by identifying much of current and past sociological research about Indigenous people and communities as damaged-centered, that is, identifying problems and obstacles in the hope that the knowledge will lead to change...
November 2016: Canadian Review of Sociology, Revue Canadienne de Sociologie
https://www.readbyqxmd.com/read/27881921/the-occurrence-and-predictive-factors-of-sleep-paralysis-in-university-students
#8
Monika Lišková, Denisa Janečková, Lucie Klůzová Kráčmarová, Karolína Mladá, Jitka Bušková
The aim of the present study was to assess the occurrence and predictive factors of sleep paralysis (SP) in Czech university students. Our sample included 606 students who had experienced at least one episode of SP. The participants completed an online battery of questionnaires involving questionnaires focused on describing their sleep habits and SP episodes, the 18-item Boundary Questionnaire (BQ-18), the Modified Tellegen Absorption Scale (MODTAS), the Dissociative Experience Scale Taxon, the Beck Depression Inventory II and the State-Trait Anxiety Inventory...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27878820/youth-and-the-great-recession-are-values-achievement-orientation-and-outlook-to-the-future-affected
#9
Ingrid Schoon, Jeylan Mortimer
This special section brings together leading experts in psychology and sociology to examine the consequences of the Great Recession for young people's values, achievement orientation, and outlook to the future. Evidence from Europe and the United States suggests that the impact of the recession varies for distinct outcomes and by age, the latter pointing to potential sensitive periods for interventions. Although the direct effects of the recession are not strong, they accelerate pre-existing trends towards more prolonged and precarious transitions to independence, and are likely to bring with them long-term scarring with respect to health and well-being...
November 23, 2016: International Journal of Psychology: Journal International de Psychologie
https://www.readbyqxmd.com/read/27875449/year-end-reindeer-dreams
#10
Peggy McDaniel
Updated several times a week with posts by a wide variety of authors, AJN's blog Off the Charts allows us to provide more timely-and often more personal-perspectives on professional, policy, and clinical issues. Best of the Blog will be a regular column to bring AJN readers recent posts that we think deserve a wider audience. To read more, please visit: www.ajnoffthecharts.com.
December 2016: American Journal of Nursing
https://www.readbyqxmd.com/read/27874869/oriented-electric-fields-as-future-smart-reagents-in-chemistry
#11
Sason Shaik, Debasish Mandal, Rajeev Ramanan
Oriented external electric fields (OEEFs) as 'smart reagents' are no longer a theoretical dream. Here, we discuss the wide-ranging potential of using OEEFs to catalyse and control a variety of non-redox reactions and impart selectivity at will. An OEEF along the direction of electron reorganization (the so-called reaction axis) will catalyse nonpolar reactions by orders of magnitude, control regioselectivity and induce spin-state selectivity. Simply flipping the direction of the OEEF or orienting it off of the reaction axis, will control at will the endo/exo ratio in Diels-Alder reactions and steps in enzymatic cycles...
November 22, 2016: Nature Chemistry
https://www.readbyqxmd.com/read/27867014/the-cave-microbiome-as-a-source-for-drug-discovery-reality-or-pipe-dream
#12
REVIEW
Soumya Ghosh, Nomeda Kuisiene, Naowarat Cheeptham
This review highlights cave habitats, cave microbiomes and their potential for drug discovery. Such studies face many challenges, including access to remote and pristine caves, and sample collection and transport. Inappropriate physical and chemical growth conditions in the laboratory for the isolation and cultivation of cave microorganisms pose many complications including length of cultivation; some cave microorganisms can take weeks and even months to grow. Additionally, DNA extraction from cave environmental samples may be difficult due to the high concentration of various minerals that are natural DNA blocking agents...
November 17, 2016: Biochemical Pharmacology
https://www.readbyqxmd.com/read/27864015/prediction-of-overall-survival-for-patients-with-metastatic-castration-resistant-prostate-cancer-development-of-a-prognostic-model-through-a-crowdsourced-challenge-with-open-clinical-trial-data
#13
Justin Guinney, Tao Wang, Teemu D Laajala, Kimberly Kanigel Winner, J Christopher Bare, Elias Chaibub Neto, Suleiman A Khan, Gopal Peddinti, Antti Airola, Tapio Pahikkala, Tuomas Mirtti, Thomas Yu, Brian M Bot, Liji Shen, Kald Abdallah, Thea Norman, Stephen Friend, Gustavo Stolovitzky, Howard Soule, Christopher J Sweeney, Charles J Ryan, Howard I Scher, Oliver Sartor, Yang Xie, Tero Aittokallio, Fang Liz Zhou, James C Costello
BACKGROUND: Improvements to prognostic models in metastatic castration-resistant prostate cancer have the potential to augment clinical trial design and guide treatment strategies. In partnership with Project Data Sphere, a not-for-profit initiative allowing data from cancer clinical trials to be shared broadly with researchers, we designed an open-data, crowdsourced, DREAM (Dialogue for Reverse Engineering Assessments and Methods) challenge to not only identify a better prognostic model for prediction of survival in patients with metastatic castration-resistant prostate cancer but also engage a community of international data scientists to study this disease...
November 15, 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27861831/freud-s-paternity-crises
#14
Edward A Jones
This article reexamines the interpretation of the significance of the Aliquis slip and related materials in terms of a family crisis in 1900 involving Freud, Anna Freud Bernays and their youngest sister Paula. It contends that Ernest Jones and Anna Freud later hid this story from history, largely for family reasons. It supports this contention by drawing on Ernest Jones and Anna Freud's archived letters, Anna Freud Bernays' memoirs, the complete Freud-Fliess letters and other historical sources and compares them to The Origins of Psychoanalysis and to Ernest Jones' biography of Freud...
November 14, 2016: International Journal of Psycho-analysis
https://www.readbyqxmd.com/read/27859181/the-analyst-s-narrative-function-inventing-a-possibility
#15
Maria Cecília Pereira da Silva
This article describes a psychic function common to analysts that was gradually revealed through clinical work with children. It is a psychic quality derived from function α, which involves analysts' capacity for reverie - their narrative function. The author presents two clinical situations where this function developed in the analytic field in relation to patients' difficulty in symbolizing. In the first case there was an early traumatic experience unavailable for representation. The analyst lent the patient her ability to represent and produced a narrative that made it possible to create a world of phantasies and transform nightmares into 'dreamable' dreams...
November 17, 2016: International Journal of Psycho-analysis
https://www.readbyqxmd.com/read/27858934/contrast-sensitivity-and-its-determinants-in-people-with-diabetes-sn-dreams-ii-report-no-6
#16
L Gella, R Raman, S S Pal, S Ganesan, T Sharma
PurposeTo assess contrast sensitivity (CS) and to elucidate the factors associated with CS among subjects with type 2 diabetes in a cross-sectional population-based study.Patients and MethodsSubjects were recruited from a follow-up cohort, Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular genetics Study (SN-DREAMS II). Of 958 subjects who were followed up in SN-DREAMS II, a subset of 653 subjects was included in the analysis. All subjects underwent a comprehensive eye examination, which included CS assessment using the Pelli-Robson chart...
November 18, 2016: Eye
https://www.readbyqxmd.com/read/27853683/medical-ethics-in-plastic-surgery-a-mini-review
#17
REVIEW
Nasrin Nejadsarvari, Ali Ebrahimi, Azin Ebrahimi, Haleh Hashem-Zade
Currently, cosmetic surgery is spread around the world. Several factors are involved in this rapidly evolving field such as socio-economic development, changes in cultural norms, globalization and the effects of Western culture, advertising, media, and mental disorders. Nowadays the cosmetic surgery is becoming a profitable business, which deals exclusively with human appearance and less from the perspective of beauty based on physical protests and considering factors such as sex, age, and race. The morality of plastic surgery subspecialty has undergone many moral dilemmas in the past few years...
September 2016: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/27843255/primary-oral-health-care-in-india-vision-or-dream
#18
REVIEW
Kotumachagi S Suresh, Pravin Kumar, Nagarathna Javanaiah, Shruti Shantappa, Pooja Srivastava
: The contemporary approach to dental caries management in children focuses on prevention than treatment. Pediatricians, general dentists and pediatric dentists must be involved in a detailed preventive program, which includes prenatal counselling, treatment of expectant mothers at risk for dental caries, infant oral health care and the establishment of the dental home, so that dental disease can be prevented in infants, starting at a young age. Various health care system and organizations in India must join together to promote oral health care for all the children and specially focused toward children from disadvantaged background and children with special health care needs...
July 2016: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/27837575/dreams-in-ancient-greek-medicine
#19
K Laios, M M Moschos, E Koukaki, E Vasilopoulos, M Karamanou, M-I Kontaxaki, G Androutsos
Dreams preoccupied the Greek and Roman world in antiquity, therefore they had a prominent role in social, philosophical, religious, historical and political life of those times. They were considered as omens and prophetic signs of future events in private and public life, and that was particularly accentuated when elements of actions which took place in the plot of dreams were associated directly or indirectly with real events. This is why it was important to use them in divination, and helped the growth of superstition and folklore believes...
July 2016: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/27829406/nightmare-frequency-in-last-trimester-of-pregnancy
#20
Michael Schredl, Maria Gilles, Isabell Wolf, Verena Peus, Barbara Scharnholz, Marc Sütterlin, Michael Deuschle
BACKGROUND: Pregnancy-related dreams are often found in pregnant women but also the number of negatively toned dreams seems to be increased in this challenging phase of a woman's life. METHODS: Nightmare frequency and subjectively experienced stress was elicited via questionnaires. The mothers-to-be were approached during their application visit about 4-8 weeks prior to delivery in three obstetric hospitals. The present analysis included 406 women aged 16-40 years in the last trimester of their pregnancy...
November 9, 2016: BMC Pregnancy and Childbirth
keyword
keyword
3147
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"