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Amy E Blevins, Elizabeth Kiscaden, Jason Bengtson
In 2015, two librarians at the Hardin Library for the Health Sciences at the University of Iowa turned their dreams into a reality and secured funding to build a zombie-themed evidence-based medicine game. The game features a "choose your own adventure" style that takes students through a scenario where a disease outbreak is taking place and a resident is asked to use evidence-based medicine skills to select a screening and diagnostic tool to use on potentially infected patients. Feedback on the game has been positive, and future plans include building additional modules on therapy, harm, and prognosis...
October 2017: Medical Reference Services Quarterly
Montserrat Pujol, Jesús Pujol, Tomás Alonso, Araceli Fuentes, Mercè Pallerola, Jovita Freixenet, Ferran Barbé, Manel Salamero, Joan Santamaría, Alex Iranzo
OBJECTIVE: To examine the presence and characteristics of idiopathic REM sleep behavior disorder (IRBD) in a representative Caucasian sample from the elderly community of Lleida, Spain, attending primary care centers. METHODS: Participants were individuals aged 60 years or older who underwent routine visits in two primary care centers. They underwent a two-stage study; a validated screening single question for IRBD diagnosis (RBD1Q) followed by, in those who endorsed positive answer, clinical assessment by a neurologist plus video-polysomnography (V-PSG)...
August 24, 2017: Sleep Medicine
Richard J McNally, Alexandre Heeren, Donald J Robinaugh
Background: The network approach to mental disorders offers a novel framework for conceptualizing posttraumatic stress disorder (PTSD) as a causal system of interacting symptoms. Objective: In this study, we extended this work by estimating the structure of relations among PTSD symptoms in adults reporting personal histories of childhood sexual abuse (CSA; N = 179).   Method: We employed two complementary methods. First, using the graphical LASSO, we computed a sparse, regularized partial correlation network revealing associations (edges) between pairs of PTSD symptoms (nodes)...
2017: European Journal of Psychotraumatology
Efstathios Karamanos, Sophie Dream, Anthony Falvo, Nathan Schmoekel, Aamir Siddiqui
CONTEXT: Use of epidural analgesia in patients undergoing elective abdominal wall reconstruction is common. OBJECTIVE: To assess the impact of epidural analgesia in patients undergoing abdominal wall reconstruction. DESIGN: All patients who underwent elective ventral hernia repair from 2005 to 2014 were retrospectively identified. Patients were divided into two groups by the postoperative use of epidural analgesics as an adjunct analgesic method...
2017: Permanente Journal
Çağdaş Yokuşoğlu, Mücahit Atasoy, Nurgül Tekeli, Ahmet Ural, Çağla Ulus, Yunus Taylan, Gülser Aydin, Gözde Gültekin, Murat Emül
INTRODUCTION: The aim of this study was to examine the level of lucidity and its relation with metacognitive beliefs and dream anxiety in medical students. METHODS: Nine hundred sixteen medical students were enrolled in the study. The participants were assessed with the Lucidity and Consciousness in Dreams Scale (LuCiD), the Metacognition Questionnaire-30 (MCQ-30), and the Van Dream Anxiety Scale (VDAS). RESULTS: There was no significant difference in mean total lucidity score between females and males, but there were some significant sex differences in subscales of lucidity, and control was significantly higher in male students, while realism, thought, and dissociation were significantly higher in female students...
September 2017: Noro Psikiyatri Arsivi
David S Goldstein, Courtney Holmes, Grisel J Lopez, Tianxia Wu, Yehonatan Sharabi
INTRODUCTION: By the time a person develops the motor manifestations of Parkinson's disease (PD), substantial loss of nigrostriatal dopamine neurons has already occurred. There is great interest in identifying biomarkers that can detect pre-clinical PD. Braak's neuropathological staging concept imputes early autonomic involvement. Here we report results from a small prospective cohort study about the utility of neuroimaging evidence of cardiac sympathetic denervation in predicting PD among individuals with multiple PD risk factors...
October 5, 2017: Parkinsonism & related Disorders
Erin M Shockley, Jasper A Vrugt, Carlos F Lopez
Summary: Biological models contain many parameters whose values are difficult to measure directly via experimentation and therefore require calibration against experimental data. Markov chain Monte Carlo (MCMC) methods are suitable to estimate multivariate posterior model parameter distributions, but these methods may exhibit slow or premature convergence in high-dimensional search spaces. Here, we present PyDREAM, a Python implementation of the (Multiple-Try) Differential Evolution Adaptive Metropolis (DREAM(ZS)) algorithm developed by Vrugt and ter Braak (2008) and Laloy and Vrugt (2012)...
October 4, 2017: Bioinformatics
Grant McKenzie, Krzysztof Janowicz
Gaining access to inexpensive, high-resolution, up-to-date, three-dimensional road network data is a top priority beyond research, as such data would fuel applications in industry, governments, and the broader public alike. Road network data are openly available via user-generated content such as OpenStreetMap (OSM) but lack the resolution required for many tasks, e.g., emergency management. More importantly, however, few publicly available data offer information on elevation and slope. For most parts of the world, up-to-date digital elevation products with a resolution of less than 10 meters are a distant dream and, if available, those datasets have to be matched to the road network through an error-prone process...
2017: PloS One
John S Andrews, James F Bale, Jennifer B Soep, Michele Long, Carol Carraccio, Robert Englander, Deborah Powell
The Education in Pediatrics Across the Continuum (EPAC) Study Group is developing the first competency-based, time-variable progression from undergraduate medical education (UME) to graduate medical education (GME) in the history of medical education in the United States. EPAC, an innovation project sponsored by the Association of American Medical Colleges (AAMC) and supported by the Josiah Macy Jr. Foundation, was developed through a collaboration between 5 medical schools and multiple professional organizations with an interest in undergraduate and graduate medical education...
October 11, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
Leide Porcu
In New York City, a man and his therapist talk about shame as a psychological, bodily, gendered, and social experience that pervades even the consulting room. They describe and analyze trauma and guilt against the background of a common Mediterranean culture they experienced while growing up, albeit from different gendered and class positions. The patient's modest presenting complaint of blushing opens into an exploration that results in an unexpectedly profound transformation. Ultimately, therapy helps him acknowledge and process his traumatic experience of circumcision and other traumas...
October 2017: Psychoanalytic Review
Bryn Williams-Jones, Vincent Couture, Renaud Boulanger, Charles Dupras
No abstract text is available yet for this article.
October 2017: American Journal of Bioethics: AJOB
Raphael Vallat, Benoit Chatard, Mark Blagrove, Perrine Ruby
Several studies have demonstrated that dream content is related to the waking life of the dreamer. However, the characteristics of the memory sources incorporated into dreams are still unclear. We designed a new protocol to investigate remote memories and memories of trivial experiences, both relatively unexplored in dream content until now. Upon awakening, for 7 days, participants identified the waking life elements (WLEs) related to their dream content and characterized them and their dream content on several scales to assess notably emotional valence...
2017: PloS One
Thérèse de Dassel, Lutz Wittmann, Sonja Protic, Helge Höllmer, Robert J Gorzka
Nightmares are among the most frequent and disturbing symptoms of posttraumatic stress disorder (PTSD). However, basic research questions regarding key associations between certain nightmare characteristics, especially replicativeness, and posttraumatic psychopathology need further empirical elaboration. Sixty-two German soldiers (mean age 33.8 years, 17.7% females) admitted to a hospital-based treatment program for veterans completed extensive assessments consisting of clinical interviews and self-rating measures with respect to sociodemographic characteristics and psychopathology as well as dream-related variables...
October 9, 2017: Psychological Trauma: Theory, Research, Practice and Policy
Kenneth Kimmel
The survivor of a decade of childhood sexual trauma and violence, perpetrated by a monstrous father, produced a series of dreams in the final year of a ten-year analysis. They illuminated the 'death drive' beneath a lifelong preoccupation with dying and fantasies of submission to death, perpetuated by the promise of hoped-for freedom from pain and release from a life of suffering. The initial dream involved the collapse of a team of white horses drawing him in a pillory cart to his own hanging for a crime he did not commit...
November 2017: Journal of Analytical Psychology
Joseph McFadden
The schism between psychiatry, psychology and analysis, while long present, has widened even more in the past half-century with the advances in psychopharmacology. With the advances in electronic brain imaging, particularly in developmental and post-traumatic stress disorders, there has emerged both an understanding of brain changes resulting from severe, chronic stress and an ability to target brain chemistry in ways that can relieve clinical symptomatology. The use of alpha-1 adrenergic brain receptor antagonists decreases many of the manifestations of PTSD...
November 2017: Journal of Analytical Psychology
Patrice Fort, Sara Valencia Garcia
No abstract text is available yet for this article.
October 2017: Médecine Sciences: M/S
Sascha Brunheim, Marcel Gratz, Sören Johst, Andreas K Bitz, Thomas M Fiedler, Mark E Ladd, Harald H Quick, Stephan Orzada
PURPOSE: Current methods for mitigation of transmit field B1+ inhomogeneities at ultrahigh field (UHF) MRI by multi-channel radiofrequency (RF) shimming rely on accurate B1+ mapping. This can be time consuming when many RF channels have to be mapped for in vivo body MRI, where the B1 maps should ideally be acquired within a single breath-hold. Therefore, a new B1+ mapping technique (B1TIAMO) is proposed. METHODS: The performance of this technique is validated against an established method (DREAM) in phantom measurements for a cylindrical head phantom with an 8-channel transmit/receive (Tx/Rx) array...
October 9, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Omolara T Uwemedimo, Ana C Monterrey, Julie M Linton
No abstract text is available yet for this article.
October 9, 2017: Pediatrics
Mehmet Gönen, Barbara A Weir, Glenn S Cowley, Francisca Vazquez, Yuanfang Guan, Alok Jaiswal, Masayuki Karasuyama, Vladislav Uzunangelov, Tao Wang, Aviad Tsherniak, Sara Howell, Daniel Marbach, Bruce Hoff, Thea C Norman, Antti Airola, Adrian Bivol, Kerstin Bunte, Daniel Carlin, Sahil Chopra, Alden Deran, Kyle Ellrott, Peddinti Gopalacharyulu, Kiley Graim, Samuel Kaski, Suleiman A Khan, Yulia Newton, Sam Ng, Tapio Pahikkala, Evan Paull, Artem Sokolov, Hao Tang, Jing Tang, Krister Wennerberg, Yang Xie, Xiaowei Zhan, Fan Zhu, Tero Aittokallio, Hiroshi Mamitsuka, Joshua M Stuart, Jesse S Boehm, David E Root, Guanghua Xiao, Gustavo Stolovitzky, William C Hahn, Adam A Margolin
We report the results of a DREAM challenge designed to predict relative genetic essentialities based on a novel dataset testing 98,000 shRNAs against 149 molecularly characterized cancer cell lines. We analyzed the results of over 3,000 submissions over a period of 4 months. We found that algorithms combining essentiality data across multiple genes demonstrated increased accuracy; gene expression was the most informative molecular data type; the identity of the gene being predicted was far more important than the modeling strategy; well-predicted genes and selected molecular features showed enrichment in functional categories; and frequently selected expression features correlated with survival in primary tumors...
October 3, 2017: Cell Systems
Nans Florens, Dan Yi, Laurent Juillard, Christophe O Soulage
Chronic kidney disease is associated with the accumulation of a large range of uremic retention solutes as referred to as uremic toxins. Some of these compounds belong to the group of Protein Bound Uremic Toxins (PBUT) due to their tight interactions with plasma proteins and especially serum albumin. These PBUT therefore exist in the bloodstream into two forms: a major bound (and non-diffusible) fraction and a minor free fraction. As a result, these compounds are poorly removed by most of the renal replacement therapies (such as hemodialysis) and their concentration can hardly be decreased in end-stage renal disease patients...
October 4, 2017: Biochimie
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