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https://www.readbyqxmd.com/read/29667836/molecular-dynamics-simulations-are-redefining-our-view-of-peptides-interacting-with-biological-membranes
#1
Jakob P Ulmschneider, Martin B Ulmschneider
Ever since the first molecular mechanics computer simulations of biological molecules became possible, there has been the dream to study all complex biological phenomena in silico, simply bypassing the enormous experimental challenges and their associated costs. For this, two inherent requirements need to be met: First, the time scales achievable in simulations must reach up to the millisecond range and even longer. Second, the computational model must accurately reproduce what is measured experimentally. Despite some recent successes, the general consensus in the field to date has been that neither of these conditions have yet been met and that the dream will be realized, if at all, only in the distant future...
April 18, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29665762/effects-of-vitamin-b6-pyridoxine-and-a-b-complex-preparation-on-dreaming-and-sleep
#2
Denholm J Aspy, Natasha A Madden, Paul Delfabbro
Anecdotal evidence indicates that supplementation with vitamin B6 (pyridoxine) before bed can enhance dream vividness and recall. In a single pilot study, Ebben, Lequerica, and Spielman (2002) found that vitamin B6 had a dose-dependent effect of increasing scores on a composite measure of dream vividness, bizarreness, emotionality, and color. The present research replicated this study using a larger and more diverse sample of 100 participants from across Australia. We conducted a randomized, double-blind, placebo-controlled investigation of the effects on dreaming and sleep of ingesting 240 mg vitamin B6 (pyridoxine hydrochloride) before bed for five consecutive days...
January 1, 2018: Perceptual and Motor Skills
https://www.readbyqxmd.com/read/29664464/the-legacy-of-dr-khalaf-al-mouteary-july-1948-january-2018
#3
Ahmed Ammar
We are hereby not only presenting and documenting the achievements of Dr. Khalaf Al Mouteary, which are great and unprecedented, but drawing lessons from his life and striving to develop and improve a system of neurosurgery practice and training in Saudi Arabia. Over 30 years of his dreams, sacrifices, hard work, vision, successes and failures in neurosurgical medical services, training and education have brought us to the position where we are in today, as one of leading countries in neurosurgery in the whole Middle East...
April 2018: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
https://www.readbyqxmd.com/read/29664058/relationships-between-rapid-eye-movement-sleep-behavior-disorder-and-neurodegenerative-diseases-clinical-assessments-biomarkers-and-treatment
#4
REVIEW
Min Li, Li Wang, Jiang-Hong Liu, Shu-Qin Zhan
Objective: Rapid eye movement sleep behavior disorder (RBD) is characterized by dream enactment and loss of muscle atonia during rapid eye movement sleep. RBD is closely related to α-synucleinopathies including Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Many studies have investigated the markers of imaging and neurophysiological, genetic, cognitive, autonomic function of RBD and their predictive value for neurodegenerative diseases. This report reviewed the progress of these studies and discussed their limitations and future research directions...
April 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29652551/n-3-fatty-acid-supplementation-for-the-treatment-of-dry-eye-disease
#5
(no author information available yet)
Background Dry eye disease is a common chronic condition that is characterized by ocular discomfort and visual disturbances that decrease quality of life. Many clinicians recommend the use of supplements of n-3 fatty acids (often called omega-3 fatty acids) to relieve symptoms. Methods In a multicenter, double-blind clinical trial, we randomly assigned patients with moderate-to-severe dry eye disease to receive a daily oral dose of 3000 mg of fish-derived n-3 eicosapentaenoic and docosahexaenoic acids (active supplement group) or an olive oil placebo (placebo group)...
April 13, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29652110/intranasal-glucagon-for-hypoglycaemia-in-diabetic-patients-an-old-dream-is-becoming-reality
#6
REVIEW
Antonio E Pontiroli, Valerio Ceriani
In 1983 it was shown that glucagon administered intranasally (IN) was absorbed through the nasal mucosa and increased blood glucose in healthy subjects. Shortly thereafter, it was shown that IN glucagon counteracts hypoglycaemia in insulin-treated diabetic patients. In spite of this evidence, IN glucagon has not been developed by any pharmaceutical company before 2010, when renewed interest led to intensive evaluation as a possible remedy for hypoglycaemia in insulin-treated diabetic adults and children. IN glucagon is now being developed as a needle-free device delivering glucagon powder for treating severe hypoglycaemia; the ease of using this device stands in stark contrast to the difficulties in preparing and injecting the current intramuscular glucagon emergency kits...
April 13, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29650552/hackathons-as-a-means-of-accelerating-scientific-discoveries-and-knowledge-transfer
#7
Amel Ghouila, Geoffrey Henry Siwo, Jean-Baka Domelevo Entfellner, Sumir Panji, Katrina A Button-Simons, Sage Zenon Davis, Faisal M Fadlelmola, Michael T Ferdig, Nicola Mulder
Scientific research plays a key role in the advancement of human knowledge and pursuit of solutions to important societal challenges. Typically, research occurs within specific institutions where data are generated and subsequently analyzed. Although collaborative science bringing together multiple institutions is now common, in such collaborations the analytical processing of the data is often performed by individual researchers within the team, with only limited internal oversight and critical analysis of the workflow prior to publication...
April 12, 2018: Genome Research
https://www.readbyqxmd.com/read/29644271/venlafaxine-induced-rem-sleep-behavioral-disorder-presenting-as-two-fractures
#8
R Ryan Williams, Gustavo Sandigo
Rapid eye movement (REM) sleep behavioral disorder is characterized by the absence of muscular atonia during REM sleep. In this disorder, patients can violently act out their dreams, placing them at risk for traumatic fractures during these episodes. REM sleep behavioral disorder (RBD) can be a sign of future neurodegenerative disease and has also been found to be a side effect of certain psychiatric medications. We present a case of venlafaxine-induced RBD in a 55 year old female who presented with a 13 year history of intermittent parasomnia and dream enactment in addition to a recent history of two fractures requiring intervention...
October 2017: Trauma Case Reports
https://www.readbyqxmd.com/read/29643182/my-winding-trail-while-fulfilling-my-love-for-science-and-family
#9
Kim Orth
My winding path toward a career in science was awkward, like an adolescent finding an identity. It did not follow a classic course; it had many interruptions, complications, and challenges. It also involved a bit of luck and extremely supportive colleagues, mentors, and family, including my husband, children, and in-laws. I was inspired to tell my story here because I met a young woman interviewing in 2018 for graduate school who is growing up with the same complicated family expectations, social challenges, love for science, and desire to be a scientist as I had four decades ago...
April 11, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29629050/perceptions-of-teenage-women-about-marriage-in-adolescence-in-an-iranian-setting-a-qualitative-study
#10
Afrouz Mardi, Abbas Ebadi, Zahra Behboodi Moghadam, Shirin Shahbazi
Background and aim: Early marriage threatens the health and human rights of millions of girls all around the world. The aim of this study was to explore the perceptions of Iranian teenage women about marriage in adolescence. Methods: A qualitative study was conducted based on the conventional content analysis approach on 14 teenage married women (aged13-19 years) who attended all urban-rural healthcare centers (4 centers) in Ardabil, Iran between May 2016 and Jan 2017...
February 2018: Electronic Physician
https://www.readbyqxmd.com/read/29623062/lucid-dreaming-intensity-but-not-frequency-is-inversely-related-to-psychopathology
#11
Liat Aviram, Nirit Soffer-Dudek
Lucid dreaming (LD) is awareness that one is dreaming, during the dream state. However, some define and assess LD relying also on controlling dream events, although control is present only in a subset of lucid dreams. LD has been claimed to represent well-being, and has even been used as a therapeutic agent. Conversely, LD is associated with mixed sleep-wake states, which are related to bizarre cognitions, stress, and psychopathology, and have been construed as arousal permeating and disrupting sleep. We propose that previous conflicting findings regarding relations between LD and both psychopathology and well-being, stem from the non-differentiated assessment of frequency and control...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29616980/direct-atomic-fabrication-and-dopant-positioning-in-si-using-electron-beams-with-active-real-time-image-based-feedback
#12
Stephen Jesse, Bethany Hudak, Eva Zarkadoula, Jiaming Song, Artem Maksov, Miguel A Fuentes-Cabrera, Panchapakesan Ganesh, Ivan Kravchenko, Paul C Snijders, Andrew Lupini, Albina Borisevich, Sergei V Kalinin
Semiconductor fabrication is a mainstay of modern civilization, enabling the myriad applications and technologies that underpin everyday life. However, while sub-10 nanometer devices are already entering the mainstream, the end of the Moore's Law roadmap still lacks tools capable of bulk semiconductor fabrication on sub-nanometer and atomic levels, with probe-based manipulation being explored as the only known pathway. Here we demonstrate that the atomic-sized focused beam of a scanning transmission electron microscope can be used to manipulate semiconductors such as Si on the atomic level, inducing growth of crystalline Si from the amorphous phase, reentrant amorphization, milling, and dopant-front motion...
April 4, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29614123/china-s-science-technology-engineering-and-mathematics-stem-research-environment-a-snapshot
#13
Xueying Han, Richard P Appelbaum
In keeping with China's President Xi Jinping's "Chinese Dream," China has set a goal of becoming a world-class innovator by 2050. China's higher education Science, Technology, Engineering, and Math (STEM) research environment will play a pivotal role in influencing whether China is successful in transitioning from a manufacturing-based economy to an innovation-driven, knowledge-based economy. Past studies on China's research environment have been primarily qualitative in nature or based on anecdotal evidence...
2018: PloS One
https://www.readbyqxmd.com/read/29610475/the-long-tail-of-oncogenic-drivers-in-prostate-cancer
#14
Joshua Armenia, Stephanie A M Wankowicz, David Liu, Jianjiong Gao, Ritika Kundra, Ed Reznik, Walid K Chatila, Debyani Chakravarty, G Celine Han, Ilsa Coleman, Bruce Montgomery, Colin Pritchard, Colm Morrissey, Christopher E Barbieri, Himisha Beltran, Andrea Sboner, Zafeiris Zafeiriou, Susana Miranda, Craig M Bielski, Alexander V Penson, Charlotte Tolonen, Franklin W Huang, Dan Robinson, Yi Mi Wu, Robert Lonigro, Levi A Garraway, Francesca Demichelis, Philip W Kantoff, Mary-Ellen Taplin, Wassim Abida, Barry S Taylor, Howard I Scher, Peter S Nelson, Johann S de Bono, Mark A Rubin, Charles L Sawyers, Arul M Chinnaiyan, Nikolaus Schultz, Eliezer M Van Allen
Comprehensive genomic characterization of prostate cancer has identified recurrent alterations in genes involved in androgen signaling, DNA repair, and PI3K signaling, among others. However, larger and uniform genomic analysis may identify additional recurrently mutated genes at lower frequencies. Here we aggregate and uniformly analyze exome sequencing data from 1,013 prostate cancers. We identify and validate a new class of E26 transformation-specific (ETS)-fusion-negative tumors defined by mutations in epigenetic regulators, as well as alterations in pathways not previously implicated in prostate cancer, such as the spliceosome pathway...
April 2, 2018: Nature Genetics
https://www.readbyqxmd.com/read/29609724/did-ren%C3%A3-descartes-have-exploding-head-syndrome
#15
Abidemi Idowu Otaiku
René Descartes (1596-1650), "the Father of Modern Philosophy" and advocate of mind-body dualism, had three successive dreams on November 10, 1619 that changed the trajectory of his life and the trajectory of human thought. Descartes' influential dreams have been of interest to a number of commentators including the famous neurologist and psychoanalyst Sigmund Freud. Descartes' second dream in particular, in which he heard a loud noise in his head before seeing a bright flash of light upon awakening, has been discussed extensively...
March 30, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29609617/genome-wide-analysis-of-gene-regulation-mechanisms-during-drosophila-spermatogenesis
#16
Petr P Laktionov, Daniil A Maksimov, Stanislav E Romanov, Polina A Antoshina, Olga V Posukh, Helen White-Cooper, Dmitry E Koryakov, Stepan N Belyakin
BACKGROUND: During Drosophila spermatogenesis, testis-specific meiotic arrest complex (tMAC) and testis-specific TBP-associated factors (tTAF) contribute to activation of hundreds of genes required for meiosis and spermiogenesis. Intriguingly, tMAC is paralogous to the broadly expressed complex Myb-MuvB (MMB)/dREAM and Mip40 protein is shared by both complexes. tMAC acts as a gene activator in spermatocytes, while MMB/dREAM was shown to repress gene activity in many cell types. RESULTS: Our study addresses the intricate interplay between tMAC, tTAF, and MMB/dREAM during spermatogenesis...
April 2, 2018: Epigenetics & Chromatin
https://www.readbyqxmd.com/read/29608764/mtor-inhibition-in-glioblastoma-requiem-for-a-dream
#17
Sam Babak, Warren P Mason
No abstract text is available yet for this article.
March 28, 2018: Neuro-oncology
https://www.readbyqxmd.com/read/29607497/low-dose-naltrexone-for-induction-of-remission-in-crohn-s-disease
#18
REVIEW
Claire E Parker, Tran M Nguyen, Dan Segal, John K MacDonald, Nilesh Chande
BACKGROUND: Crohn's disease is a transmural, relapsing inflammatory condition afflicting the digestive tract. Opioid signalling, long known to affect secretion and motility in the gut, has been implicated in the inflammatory cascade of Crohn's disease. Low dose naltrexone, an opioid antagonist, has garnered interest as a potential therapy. OBJECTIVES: The primary objective was to evaluate the efficacy and safety of low dose naltrexone for induction of remission in Crohn's disease...
April 1, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29606318/kleine-levin-syndrome-a-neuropsychiatric-disorder
#19
REVIEW
I Arnulf, E Groos, P Dodet
Kleine-Levin syndrome (KLS) is a rare, relapsing-remitting disease that affects mostly adolescents. It is characterized by episodes lasting from 1 to several weeks, and comprises neurological (hypersomnia, confusion, slowness, amnesia) and neuropsychiatric symptoms (derealization and apathy). Some psychiatric symptoms (megaphagia, hypersexuality, anxiety, depressed mood, hallucinations, delusions) arise during episodes, albeit less frequently, while patients are normal between episodes. However, sudden severe (>18h/day of sleep) and recurrent hypersomnia helps to differentiate KLS from other psychiatric mimics...
March 30, 2018: Revue Neurologique
https://www.readbyqxmd.com/read/29603725/digest-life-history-evolution-in-darwin-s-dream-ponds
#20
Foteini Spagopoulou, Mozes P K Blom
Can variation in sex-specific parental investment lead to sexual dimorphism in immune response? Keller et al. (2018) measured immune cell parameters, expression of candidate genes and composition of buccal microbiota in mouthbrooding cichlid species from Lake Tanganyika that show either maternal or biparental care. They found that maternal mouthbrooding species have increased sexual dimorphism in immune parameters, while biparental mouthbrooders exhibit an upregulated adaptive immune response, suggesting resource allocation shifts between parental investment and the immune system...
March 31, 2018: Evolution; International Journal of Organic Evolution
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