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Yi-Mi Wu, Marcin Cieślik, Robert J Lonigro, Pankaj Vats, Melissa A Reimers, Xuhong Cao, Yu Ning, Lisha Wang, Lakshmi P Kunju, Navonil de Sarkar, Elisabeth I Heath, Jonathan Chou, Felix Y Feng, Peter S Nelson, Johann S de Bono, Weiping Zou, Bruce Montgomery, Ajjai Alva, Dan R Robinson, Arul M Chinnaiyan
Using integrative genomic analysis of 360 metastatic castration-resistant prostate cancer (mCRPC) samples, we identified a novel subtype of prostate cancer typified by biallelic loss of CDK12 that is mutually exclusive with tumors driven by DNA repair deficiency, ETS fusions, and SPOP mutations. CDK12 loss is enriched in mCRPC relative to clinically localized disease and characterized by focal tandem duplications (FTDs) that lead to increased gene fusions and marked differential gene expression. FTDs associated with CDK12 loss result in highly recurrent gains at loci of genes involved in the cell cycle and DNA replication...
June 14, 2018: Cell
Koji Kasanuki, Keith A Josephs, Tanis J Ferman, Melissa E Murray, Shunsuke Koga, Takuya Konno, Nobutaka Sakae, Adam Parks, Ryan J Uitti, Jay A Van Gerpen, Neill R Graff-Radford, Zbigniew K Wszolek, Dennis W Dickson
OBJECTIVE: To describe clinical and pathologic characteristics of diffuse Lewy body disease (DLBD) manifesting as corticobasal syndrome (CBS). METHODS: In 523 autopsy-confirmed cases of DLBD, we identified 11 patients diagnosed with CBS. For comparison, we studied 22 DLBD brains with antemortem presentation of dementia with Lewy bodies (DLB). Given previous studies suggesting the importance of pathology in peri-Rolandic cortices in CBS, we used digital pathology to count Lewy bodies and to quantify intracytoplasmic and neuritic α-synuclein and phospho-tau burden in the motor cortex...
June 13, 2018: Neurology
Thomas Wiesmann, Jens Döffert, Thorsten Steinfeldt
No abstract text is available yet for this article.
June 11, 2018: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
Revital Nimri, Eyal Dassau, Tomer Segall, Ido Muller, Natasa Bratina, Olga Kordonouri, Rachel Bello, Torben Biester, Klemen Dovc, Ariel Tenenbaum, Avivit Brener, Marko Šimunović, Sophia D Sakka, Michal Nevo Shenker, Caroline Gb Passone, Irene Rutigliano, Davide Tinti, Clara Bonura, Silvana Caiulo, Anna Ruszala, Barbara Piccini, Dinesh Giri, Ronnie Stein, Ivana Rabbone, Patrizia Bruzzi, Jasna Šuput Omladič, Caroline Steele, Guglielmo Beccuti, Michal Yackobovitch-Gavan, Tadej Battelino, Thomas Danne, Eran Atlas, Moshe Phillip
AIMS: To evaluate physicians' adjustments of insulin pump settings based on continuous glucose monitoring (CGM) for patients with type 1 diabetes and to compare physicians' to automated insulin dose adjustments. METHODS: 26 physicians from 16 centers in Europe, Israel and South-America participated in the study. All were asked to adjust insulin dosing based on insulin pump, CGM and glucometer downloads of 15 patients (mean age 16.2 ± 4.3 y, 6 females, mean A1c 8...
June 8, 2018: Diabetes, Obesity & Metabolism
Daniel A Barone, Claire Henchcliffe
Rapid eye movement (REM) sleep behavior disorder (RBD) involves REM sleep without atonia in conjunction with a recurrent nocturnal dream enactment behavior, with vocalizations such as shouting and screaming, and motor behaviors such as punching and kicking. Secondary RBD is well described in association with neurological disorders including Parkinson's disease (PD), multiple system atrophy (MSA), and other conditions involving brainstem structures such as tumors. However, RBD alone is now considered to be a potential harbinger of later development of neurodegenerative disorders, in particular PD, MSA, dementia with Lewy bodies (DLB), and pure autonomic failure...
May 29, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
Penny A Asbell, Maureen G Maguire, Ellen Peskin, Vatinee Y Bunya, Eric J Kuklinski
PURPOSE: Describe trial design and baseline characteristics of participants in the DRy Eye Assessment and Management (DREAM©) Study. DESIGN: Prospective, multi-center, randomized, double-masked "real-world" clinical trial assessing efficacy and safety of oral omega-3 (ω3) supplementation for the treatment of dry eye disease (DED). METHODS: RESULTS: Mean age of participants was 58.0 ± 13.2 years. Mean OSDI score at baseline was 44...
June 5, 2018: Contemporary Clinical Trials
J R Son, Y Liu, Q N Ma, B Z Ju, K F Sun, J D Wu, L D Zhang, G L Yang
In the Huang di nei jing ( Huangdi ' s Internal Classic ), jin ye (fluid and humor) is described in two senses, broad and narrow, though not so strictly.Sometimes, jin ye is explained ambiguously as "sweat" and "urine" , as in the phrase "the bladder, being a house of jin ye " , here " jin ye " refers to the urine. In the Qi jue lun pian of Su wen ( Chapter on Qi - Syncope of Plain Questions ) , the " bao " in the sentence "heat of bao moved to bladder" refersto the uterus...
September 28, 2017: Zhonghua Yi Shi za Zhi, Chinese Journal of Medical History
Tyler Werbel, Philip R Cohen
Ranitidine is an H2 antihistamine used as an off-label therapy for recalcitrant verruca vulgaris. We describe a man who developed a sleep disturbance after initiating therapy with ranitidine and review similar adverse effects associated with other drugs in this class. The patient was a 40-year-old man with an eight-year history of a wart on his right plantar foot that was recalcitrant to several topical therapies. Adjunctive treatment with ranitidine 150 mg twice daily was initiated. He developed sleep disturbance with bizarre dreams and gastrointestinal symptoms...
April 3, 2018: Curēus
Ana P Rivera-García, Irma E López Ruiz, Ignacio Ramírez-Salado, Jorge J González-Olvera, Fructuoso Ayala-Guerrero, Anabel Jiménez-Anguiano
Although motor activity is actively inhibited during rapid eye movement (REM) sleep, specific activations of the facial mimetic musculature have been observed during this stage, which may be associated with greater emotional dream mentation. Nevertheless, no specific biomarker of emotional valence or arousal related to dream content has been identified to date. In order to explore the electromyographic (EMG) activity (voltage, number, density and duration) of the corrugator and zygomaticus major muscles during REM sleep and its association with emotional dream mentation, this study performed a series of experimental awakenings after observing EMG facial activations during REM sleep...
June 4, 2018: Journal of Sleep Research
Lokmane Chebouba, Dalila Boughaci, Carito Guziolowski
The use of data issued from high throughput technologies in drug target problems is widely widespread during the last decades. This study proposes a meta-heuristic framework using stochastic local search (SLS) combined with random forest (RF) where the aim is to specify the most important genes and proteins leading to the best classification of Acute Myeloid Leukemia (AML) patients. First we use a stochastic local search meta-heuristic as a feature selection technique to select the most significant proteins to be used in the classification task step...
June 4, 2018: Journal of Medical Systems
Jean-Baptiste Eichenlaub, Elaine van Rijn, M Gareth Gaskell, Penelope A Lewis, Emmanuel Maby, Josie Malinowski, Matthew P Walker, Frederic Boy, Mark Blagrove
Rapid Eye Movement (REM) sleep and its main oscillatory feature, frontal theta, have been related to the processing of recent emotional memories. As memories constitute much of the source material for our dreams, we explored the link between REM frontal theta and the memory sources of dreaming, so as to elucidate the brain activities behind the formation of dream content. Twenty participants were woken for dream reports in REM and Slow Wave Sleep (SWS) while monitored using electroencephalography. Eighteen participants reported at least one REM dream and 14 at least one SWS dream, and they, and independent judges, subsequently compared their dream reports with log records of their previous daily experiences...
June 4, 2018: Social Cognitive and Affective Neuroscience
Jason C Sanders, Timothy N Showalter
Big data and comparative effectiveness research methodologies can be applied within the framework of a rapid-learning health-care system (RLHCS) to accelerate discovery and to help turn the dream of fully personalized medicine into a reality. We synthesize recent advances in genomics with trends in big data to provide a forward-looking perspective on the potential of new advances to usher in an era of personalized radiation therapy, with emphases on the power of RLHCS to accelerate discovery and the future of individualized radiation treatment planning...
2018: Frontiers in Oncology
Dieter Kunz, Frederik Bes
INTRODUCTION: REM sleep behavior disorder (RBD) is considered a prodromal phase of α-synucleinopathy like Parkinson disease (PD). PD is characterized by a progressive decline of dopamine (DA) in the striatum. Here we report the surprising increase in DA transporter density over successive years in an RBD patient treated with melatonin. CASE PRESENTATION: A then 72-year-old man was clinically suspected to suffer from PD in 2011. DA transporter scintigraphy (DaTSCAN) revealed reduced DA transporter density, and the patient was diagnosed with developing PD...
June 1, 2018: Neuropsychobiology
Abdhalah Ziraba, Benedict Orindi, Sheru Muuo, Sian Floyd, Isolde J Birdthistle, Joyce Mumah, Jane Osindo, Pauline Njoroge, Caroline W Kabiru
INTRODUCTION: High incidence of HIV infection among adolescent girls and young women (AGYW) has been attributed to the numerous and often layered vulnerabilities that they encounter including violence against women, unfavourable power relations that are worsened by age-disparate sexual relations, and limited access to sexual and reproductive health information and services. For AGYW living in urban informal settlements (slums), these vulnerabilities are compounded by pervasive poverty, fragmented social networks, and limited access to social services including health and education...
2018: PloS One
Alex Iranzo
REM sleep is characterized by rapid eye movements, desynchronized electroencephalographic activity, dreams and muscle paralysis that preclude the individual from acting out the action of dreams. REM sleep is generated and modulated by a complex and still poorly understood, neuronal network that involves multiple nuclei and neurotransmission systems. The key structures that generate REM sleep muscle paralysis are the subcoeruleus nucleus in the mesopontine tegmentum and the reticular formation of the ventral medial medulla...
May 30, 2018: Cell and Tissue Research
Mary Anna Venneri, Valeria Hasenmajer, Daniela Fiore, Emilia Sbardella, Riccardo Pofi, Chiara Graziadio, Daniele Gianfrilli, Claudia Pivonello, Mariarosaria Negri, Fabio Naro, Ashley B Grossman, Andrea Lenzi, Rosario Pivonello, Andrea M Isidori
Context: Adrenal insufficiency (AI) requires life-long glucocorticoid replacement. Conventional therapies fail to mimic the endogenous cortisol circadian rhythm. Clock genes are essential components of the molecular machinery controlling an organ's circadian function and are influenced by glucocorticoids. However, clock gene expression has never been investigated in AI patients. Objective: To evaluate the effect of the timing of glucocorticoid administration on circadian gene expression in peripheral blood mononuclear cells (PBMCs) of AI patients from the DREAM trial...
May 25, 2018: Journal of Clinical Endocrinology and Metabolism
Yumi Motooka, Toshinobu Matsui, Rachel M Slaton, Ryogo Umetsu, Akiho Fukuda, Misa Naganuma, Shiori Hasegawa, Sayaka Sasaoka, Haruna Hatahira, Kazuhiro Iguchi, Mitsuhiro Nakamura
Objectives: Several smoking cessation treatments (nicotine replacement therapy and non-nicotine prescription medication) and electronic cigarettes are widely used. We evaluated the adverse events related to smoking cessation treatments and electronic cigarettes in the US Food and Drug Administration Adverse Event Reporting System database. Methods: We analyzed reports of adverse events associated with smoking cessation treatment and electronic cigarettes terms dated between January 2004 and December 2016...
2018: SAGE Open Medicine
Thuy Hoang, Abhijit A Date, Jairo Ortiz Ortiz, Ting-Wei Young, Sabrine Bensouda, Peng Xiao, Mark Marzinke, Lisa Rohan, Edward J Fuchs, Craig Hendrix, Sanjeev Gumber, Francois Villinger, Richard A Cone, Justin Hanes, Laura M Ensign
HIV pre-exposure prophylaxis (PrEP) strategies have the potential to prevent millions of incident HIV infections each year. However, the efficacy of PrEP strategies has been plagued by issues of non-adherence, likely because of the difficulty in motivating otherwise healthy people to adhere to treatment regimens that require significant behavioral changes and daily discipline. An alternative approach to PrEP is to focus on strategies that fit in to normal, and even desirable, sexual behaviors, such as the use of cleansing enemas by men who have sex with men (MSM) prior to receptive anal intercourse (RAI)...
May 23, 2018: European Journal of Pharmaceutics and Biopharmaceutics
Jiaojiao Ren, Miaomiao Zhao, Baohua Liu, Qunhong Wu, Yanhua Hao, Mingli Jiao, Lemeng Qu, Ding Ding, Ning Ning, Zheng Kang, Libo Liang, Huan Liu, Tong Zheng
The purpose of our research was to (a) identify sleep quality complications experienced by patients living with HIV infection and treated with antiretroviral therapy (ART), and (b) explore factors associated with sleep quality complications. From March to August in 2013, a cross-sectional study was conducted at HIV-designated hospitals in Harbin of Heilongjiang Province, China. Participants completed a questionnaire using the Spiegel scale to assess sleep quality; 32.1% of patients were negatively affected by sleep disturbances...
April 23, 2018: Journal of the Association of Nurses in AIDS Care: JANAC
Margo A Halm, Kristen Crusoe
Sustaining a clinical excellence culture for Magnet® redesignation requires continued engagement of frontline nurses, nurse leaders, and executives. Appreciative Inquiry is a strength-based approach emanating from a positive core. From this core, teams discover, dream, design, and create their preferred destiny. This article describes how a Magnet-designated organization used Appreciative Inquiry to revitalize its redesignation preparation and beyond.
June 2018: Journal of Nursing Administration
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