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Stephen P Becker, Melissa R Dvorsky, Alex S Holdaway, Aaron M Luebbe
Using a large sample of college students, objectives were to examine (1) the overlap between poor sleep and suicide risk status, (2) whether poor sleep was associated with suicide behaviors above and beyond depression, (3) whether sleep problems and depression interacted to predict increased suicidal behaviors or risk, and (4) which specific components of sleep were uniquely associated with suicidal behaviors. Participants were 1700 college students (ages 18-29 years; 65% female) from two universities who completed measures assessing sleep, depressive symptoms, and suicidal behaviors (Suicidal Behaviors Questionnaire-Revised [SBQ-R], a composite measure including ideation, past attempt, disclosure to others, and future likelihood of suicide that includes a cutoff for determining participants with suicide risk)...
January 12, 2018: Journal of Psychiatric Research
Andrew Curry
For years, an artificial pancreas was a pipe dream. Now, we're closer than ever to systems that will automatically adjust background insulin. Here's what's in the works--and what's still to come.
May 2017: Diabetes Forecast
(no author information available yet)
No abstract text is available yet for this article.
February 15, 2018: Nature
Y-K Kang, M-H Ryu, S H Park, J G Kim, J W Kim, S-H Cho, Y-L Park, S R Park, S Y Rha, M J Kang, J Y Cho, S Y Kang, S Y Roh, B-Y Ryoo, B-H Nam, Y-W Jo, K-E Yoon, S C Oh
Background: Paclitaxel is currently only available as an intravenous (IV) formulation. DHP107 is a novel oral formulation of lipid ingredients and paclitaxel. DHP107 demonstrated comparable efficacy, safety, and pharmacokinetics to IV paclitaxel as second-line therapy in patients with advanced gastric cancer (AGC). DREAM is a multicenter, open-label, prospective, randomized phase III study of patients with histologically/cytologically confirmed, unresectable/recurrent AGC after first-line therapy failure...
February 9, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Bernd Feige, Svetoslava Nanovska, Chiara Baglioni, Benedict Bier, Laura Cabrera, Sarah Diemers, Maximilian Quellmalz, Markus Siegel, Ireni Xeni, Andras Szentkiralyi, John-Peter Doerr, Dieter Riemann
Study Objectives: Insomnia disorder (ID) is a frequent sleep disorder coupled with increased risks for somatic and mental illness. While subjective complaints are severe, polysomnography (PSG) parameters show only modest differences between groups. REM sleep as the most aroused sleep state may be especially vulnerable to be perceived as wake. To directly assess possible differences, we determined auditory waking thresholds and sleep perception in ID patients and healthy control subjects (GSC) in N2 and REM sleep...
February 8, 2018: Sleep
Cezary Żechowski
The article discusses the development of psychoanalytic theory in the direction of broadening the reflection on their own based on data derived from empirical studies other than clinical case study. Particularly noteworthy is the convergence that followed between neuroscience and psychoanalysis and the rise of the so-called neuropsychoanalysis. Consequently, this led to eject empirical hypotheses and begin research on defense mechanisms, self, memory, dreams, empathy, dynamic unconscious and emotional-motivational processes (theory of drives)...
December 30, 2017: Psychiatria Polska
Benjamin D Pollock, Emily W Harville, Katherine T Mills, Wan Tang, Wei Chen, Lydia A Bazzano
BACKGROUND: Economic literature shows that a child's future earnings are predictably influenced by parental income, providing an index of "socioeconomic mobility," or the ability of a person to move towards a higher socioeconomic status from childhood to adulthood. We adapted this economic paradigm to examine cardiovascular risk mobility (CRM), or whether there is life course mobility in relative cardiovascular risk. METHODS AND RESULTS: Participants from the BHS (Bogalusa Heart Study) with 1 childhood and 1 adult visit from 1973 to 2016 (n=7624) were considered...
February 6, 2018: Journal of the American Heart Association
Yiyi Liu, Forrest W Crawford
In-vitro chemo-sensitivity experiments are an essential step in the early stages of cancer therapy development, but existing data analysis methods suffer from problems with fitting, do not permit assessment of uncertainty, and can give misleading estimates of cell growth inhibition. We present an approach (bdChemo) based on a mechanistic model of cell division and death that permits rigorous statistical analyses of chemo-sensitivity experiment data by simultaneous estimation of cell division and apoptosis rates as functions of dose, without making strong assumptions about the shape of the dose-response curve...
February 9, 2018: Scientific Reports
Stephan A Schwartz
No abstract text is available yet for this article.
December 23, 2017: Explore: the Journal of Science and Healing
Carlos A Jiménez-Ruiz, Marcos Garcia Rueda, Manuel A Martinez Muñiz, Jacobo Sellarés, Maria A Jiménez-Fuentes, Lourdes Lázaro Asegurado, Esther Rodríguez Gonzalez, Concepción Rodriguez Garcia, Oriol Armengol, Emilia Abad, Teresa Peña, Adolfo Domenech Del Rio, Juan A Riesco Miranda
A large number of COPD patients are smokers. The particular characteristics of this group as well as their need to quit usually require psychological counselling and pharmacological treatment to achieve abstinence and, often, intensively. Little information is available about this issue.  The main objective of the study was to evaluate the effectiveness of varenicline after 24 weeks of treatment, with continuous abstinence between weeks 9 and 24.  This study was a post-authorization, open label, observational study of prospective follow-up...
December 19, 2017: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
Judy K Eekhoff
This paper discusses the use of somatic countertransference as a means of learning about the patient, about projective and adhesive identification and about the object relating nature of the most traumatized and withdrawn part of the personality. It assumes an elemental knowledge of British Object Relations and uses clinical material to illustrate the hypotheses that somatic countertransference is an indicator of a very elemental communication occurring from the aspect of the psyche that is united in a body mind or mind body...
February 8, 2018: American Journal of Psychoanalysis
Delphine Oudiette, Pauline Dodet, Nahema Ledard, Emilie Artru, Inès Rachidi, Thomas Similowski, Isabelle Arnulf
Breathing is irregular during rapid eye-movement (REM) sleep, whereas it is stable during non-REM sleep. Why this is so remains a mystery. We propose that irregular breathing has a cortical origin and reflects the mental content of dreams, which often accompany REM sleep. We tested 21 patients with narcolepsy who had the exceptional ability to lucid dream in REM sleep, a condition in which one is conscious of dreaming during the dream and can signal lucidity with an ocular code. Sleep and respiration were monitored during multiple naps...
February 8, 2018: Scientific Reports
Manoj Pawar
It is a dream of every young researcher or postgraduate student to publish an article in an indexed journal and to present an oral paper or poster at a reputed conference. Unfortunately these young researchers are commonly fallen prey to predatory publications which have become a major hazard in recent years because of their rapid multidisciplinary proliferation. In fact many dermatologists daily come across with such fraudulent journals which have quite matured and rooted and now days, flourished with conference version i...
February 8, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Murray A Raskind, Elaine R Peskind, Bruce Chow, Crystal Harris, Anne Davis-Karim, Hollie A Holmes, Kimberly L Hart, Miles McFall, Thomas A Mellman, Christopher Reist, Jennifer Romesser, Robert Rosenheck, Mei-Chiung Shih, Murray B Stein, Robert Swift, Theresa Gleason, Ying Lu, Grant D Huang
BACKGROUND: In randomized trials, prazosin, an α1-adrenoreceptor antagonist, has been effective in alleviating nightmares associated with post-traumatic stress disorder (PTSD) in military veterans. METHODS: We recruited veterans from 13 Department of Veterans Affairs medical centers who had chronic PTSD and reported frequent nightmares. Participants were randomly assigned to receive prazosin or placebo for 26 weeks; the drug or placebo was administered in escalating divided doses over the course of 5 weeks to a daily maximum of 20 mg in men and 12 mg in women...
February 8, 2018: New England Journal of Medicine
Lorenzo Alibardi
Appendage regeneration occurs by a sequence of events resembling those that take place during development in the embryo. This requires embryonic conditions such as hydration and hyaluronate content where Wnt and other signaling pathways, together with non- coding RNAs, can be re-expressed. These conditions among vertebrates are fully met only in amputated limbs of amphibians, likely because they are neotenic and maintain larval characteristics, including immaturity of their immune system and permanence of numerous stem cells...
February 3, 2018: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
Raphael Vallat, Mickael Eskinazi, Alain Nicolas, Perrine Ruby
There is a lack of up-to-date data on sleep and dream habits of college students. To fill in this gap, we used an online questionnaire sent to the student mailing lists of two major universities of Lyon (Lyon 1 and Lyon 2) for the recruitment of an functional magnetic resonance imaging study with sleep disorders as exclusion criteria. In the sample (1,137 French college students, 411 males, mean age = 22.2 ± 2.4 years, body mass index = 22.0 ± 3.2 kg m-2 ), on average, the participants reported spending about 8 hr in bed during weekdays, 9 hr during the weekends, and 90...
February 6, 2018: Journal of Sleep Research
Camila Sanz, Enzo Tagliazucchi
Ever since the modern rediscovery of psychedelic substances by Western society, several authors have independently proposed that their effects bear a high resemblance to the dreams and dreamlike experiences occurring naturally during the sleep-wake cycle. Recent studies in humans have provided neurophysiological evidence supporting this hypothesis. However, a rigorous comparative analysis of the phenomenology ("what it feels like" to experience these states) is currently lacking. We investigated the semantic similarity between a large number of subjective reports of psychoactive substances and reports of high/low lucidity dreams, and found that the highest-ranking substance in terms of the similarity to high lucidity dreams was the serotonergic psychedelic lysergic acid diethylamide (LSD), whereas the highest-ranking in terms of the similarity to dreams of low lucidity were plants of the Datura genus, rich in deliriant tropane alkaloids...
2018: Frontiers in Neuroscience
Hector Ortega, Steven W Yancey, Oliver N Keene, Necdet B Gunsoy, Frank C Albers, Peter H Howarth
BACKGROUND: Limited data describe the association between the frequency of asthma exacerbations and the decline in lung function in severe asthma. OBJECTIVE: To determine whether asthma exacerbations are associated with enhanced decline in lung function. METHODS: Changes in lung function were analyzed retrospectively using data from the DREAM and MENSA studies of mepolizumab intervention in patients with severe asthma. Patients were either nonsmokers or former smokers...
February 1, 2018: Journal of Allergy and Clinical Immunology in Practice
Nikolay V Kukushkin
Memory is typically defined through animal behavior, but this point of view may limit our understanding of many related processes in diverse biological systems. The concept of memory can be broadened meaningfully by considering it from the perspective of time and homeostasis. On the one hand, this theoretical angle can help explain and predict the behavior of various non-neural systems such as insulin-secreting cells, plants, or signaling cascades. On the other hand, it emphasizes biological continuity between neural phenomena, such as synaptic plasticity, and their evolutionary precursors in cellular signaling...
January 30, 2018: Neurobiology of Learning and Memory
Marcos G Frank, Julie Seibt
No abstract text is available yet for this article.
December 26, 2017: Sleep Medicine Reviews
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