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https://www.readbyqxmd.com/read/28763510/chromosomal-diversity-and-molecular-divergence-among-three-undescribed-species-of-neacomys-rodentia-sigmodontinae-separated-by-amazonian-rivers
#1
Willam Oliveira Da Silva, Julio Cesar Pieczarka, Malcolm Andrew Ferguson-Smith, Patricia Caroline Mary O'Brien, Ana Cristina Mendes-Oliveira, Iracilda Sampaio, Jeferson Carneiro, Cleusa Yoshiko Nagamachi
The Neacomys genus (Rodentia, Sigmodontinae) is distributed in the Amazon region, with some species limited to a single endemic area, while others may occur more widely. The number of species within the genus and their geographical boundaries are not known accurately, due to their high genetic diversity and difficulties in taxonomic identification. In this work we collected Neacomys specimens from both banks of the Tapajós River in eastern Amazon, and studied them using chromosome painting with whole chromosome probes of Hylaeamys megacephalus (HME; Rodentia, Sigmodontinae), and molecular analysis using haplotypes of mitochondrial genes COI and Cytb...
2017: PloS One
https://www.readbyqxmd.com/read/28746834/development-of-an-analytical-method-for-crystalline-content-determination-in-amorphous-solid-dispersions-produced-by-hot-melt-extrusion-using-transmission-raman-spectroscopy-a-feasibility-study
#2
L Netchacovitch, E Dumont, J Cailletaud, J Thiry, C De Bleye, P-Y Sacré, M Boiret, B Evrard, Ph Hubert, E Ziemons
The development of a quantitative method determining the crystalline percentage in an amorphous solid dispersion is of great interest in the pharmaceutical field. Indeed, the crystalline Active Pharmaceutical Ingredient transformation into its amorphous state is increasingly used as it enhances the solubility and bioavailability of Biopharmaceutical Classification System class II drugs. One way to produce amorphous solid dispersions is the Hot-Melt Extrusion (HME) process. This study reported the development and the comparison of the analytical performances of two techniques, based on backscattering and transmission Raman spectroscopy, determining the crystalline remaining content in amorphous solid dispersions produced by HME...
July 23, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28741140/melt-extrusion-for-a-high-melting-point-compound-with-improved-solubility-and-sustained-release
#3
Jiannan Lu, Sakae Obara, Fei Liu, Wanyi Fu, Wen Zhang, Shingo Kikuchi
The objective of the current study was to develop an amorphous solid dispersion for a high melting point compound, griseofulvin (GRF), with an enhanced solubility and a controlled release pattern utilizing hot melt extrusion (HME) technology. Hypromellose acetate succinate (HPMCAS, Shin-Etsu AQOAT®, medium particle size) was explored as the polymeric carrier, while hypromellose (HPMC, Metolose® SR) was chosen as the release rate control agent. GRF presented an HPMCAS grade-dependent solubility: AS-HMP > AS-MMP > AS-LMP...
July 24, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28741064/injectable-sustained-release-depots-of-plga-microspheres-for-insoluble-drugs-prepared-by-hot-melt-extrusion
#4
Yuting Guo, Yunning Yang, Luying He, Rong Sun, Chenguang Pu, Bin Xie, Haibing He, Yu Zhang, Tian Yin, Yanjiao Wang, Xing Tang
PURPOSE: Progesterone (PRG) was selected as a model drug to develop a long-acting injection system for poorly water-soluble drugs. METHODS: Microspheres with high density-low porosity were prepared by hot-melt extrusion (HME) combined with wet-milling as the representative formulation, and a microcrystal suspension was also studied as a comparison. The morphology, particle size and distribution, polymorphism, drug distribution, density and porosity were characterized by scanning electron microscopy, laser diffraction particle size analyzer, power X-ray diffraction and DSC respectively...
July 24, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28727846/effects-of-high-intensity-interval-versus-mild-intensity-endurance-training-on-metabolic-phenotype-and-corticosterone-response-in-rats-fed-a-high-fat-or-control-diet
#5
Youqing Shen, Guoyuan Huang, Bryan P McCormick, Tao Song, Xiangfeng Xu
The aim of the present study was to compare the effects of high-intensity interval training (HI) to mild-intensity endurance training (ME), combined with a high-fat diet (HFD) or control diet (CD) on metabolic phenotype and corticosterone levels in rats. Fifty-three rats were randomized to 6 groups according to diet and training regimen as follows: CD and sedentary (CS, n = 11), CD and ME (CME, n = 8), CD and HI (CHI, n = 8), HFD and sedentary (HS, n = 10), HFD and ME (HME, n = 8), and HFD and HI (HHI, n = 8)...
2017: PloS One
https://www.readbyqxmd.com/read/28727788/oecomys-catherinae-sigmodontinae-cricetidae-evidence-for-chromosomal-speciation
#6
Stella Miranda Malcher, Julio Cesar Pieczarka, Lena Geise, Rogério Vieira Rossi, Adenilson Leão Pereira, Patricia Caroline Mary O'Brien, Paulo Henrique Asfora, Victor Fonsêca da Silva, Maria Iracilda Sampaio, Malcolm Andrew Ferguson-Smith, Cleusa Yoshiko Nagamachi
Among the Oryzomyini (Sigmodontinae), Oecomys is the most speciose, with 17 species. This genus presents high karyotypic diversity (2n = 54 to 2n = 86) and many taxonomic issues at the species level because of the presence of cryptic species and the overlap of morphological characters. For these reasons the real number of species of Oecomys may be underestimated. With the aim of verifying if the taxon Oecomys catherinae is composed of more than one species, we made comparative studies on two populations from two regions of Brazil, one from the Amazon and another from the Atlantic Forest using both classical cytogenetics (G- and C-banding) and comparative genomic mapping with whole chromosome probes of Hylaeamys megacephalus (HME), molecular data (cytochrome b mitochondrial DNA) and morphology...
2017: PloS One
https://www.readbyqxmd.com/read/28684263/development-of-maltodextrin-based-immediate-release-tablets-using-an-integrated-twin-screw-hot-melt-extrusion-and-injection-molding-continuous-manufacturing-process
#7
Vibha Puri, Dave Brancazio, Parind M Desai, Keith D Jensen, Jung-Hoon Chun, Allan S Myerson, Bernhardt L Trout
The combination of hot-melt extrusion and injection molding (HME-IM) is a promising process technology for continuous manufacturing of tablets. However, there has been limited research on its application to formulate crystalline drug-containing immediate-release tablets. Furthermore, studies that have applied the HME-IM process to molded tablets have used a noncontinuous 2-step approach. The present study develops maltodextrin (MDX)-based extrusion-molded immediate-release tablets for a crystalline drug (griseofulvin) using an integrated twin-screw HME-IM continuous process...
July 4, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28666964/developing-quantitative-in-vitro-in-vivo-correlation-ivivc-for-fenofibrate-immediate-release-formulations-with-the-biphasic-dissolution-partition-test-method
#8
Hao Xu, Yi Shi, Socrates Vela, Patrick Marroum, Ping Gao
This study is to evaluate three fenofibrate formulations including Fournier® 200 mg capsule, Lipidil® 145 mg tablet, and a clinical HME 160 mg tablet by an in vitro biphasic method. Key experimental parameters were evaluated including the selection of biorelevant media, the USP IV flowrate and the USP paddle speed. Varying the hydrodynamic condition resulted in a significant impact on FEN concentration time profiles in both aqueous and octanol phases for these formulations. In vivo pharmacokinetic profiles of the HME tablet, the Lipidil tablet and Fournier capsule under the fasting and low fat fed states are reported...
June 27, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28659589/vitamin-d-modulation-of-trail-expression-in-human-milk-and-mammary-epithelial-cells
#9
Yuvaraj Sambandam, Sakamuri V Reddy, Jennifer L Mulligan, Christina Voelkel-Johnson, Carol L Wagner
The vitamin D levels in mothers affect the health status of both the mother and breastfeeding infant. Vitamin D deficient mothers' infants are prone to rickets. While tumor necrosis factor-related apoptosis inducing ligand (TRAIL) has been implicated in cellular growth/apoptosis, immune cell function and bone-resorbing osteoclast formation, the expression of TRAIL in human milk as a function of vitamin D status in mothers remains unknown. We hypothesized that vitamin D deficiency alters TRAIL protein levels in human breast milk and mammary epithelial cells...
June 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28603020/hot-melt-extrusion-as-solvent-free-technique-for-a-continuous-manufacturing-of-drug-loaded-mesoporous-silica
#10
Natalja Genina, Batol Hadi, Korbinian Löbmann
The aim of this study is to explore hot melt extrusion (HME) as a solvent-free drug loading technique for preparation of stable amorphous solid dispersions using mesoporous silica (PSi). Ibuprofen and carvedilol were used as poorly soluble active pharmaceutical ingredients (APIs). Due to the high friction of an API:PSi mixture below the loading limit of the API, it was necessary to add the polymer Soluplus(®) (SOL) in order to enable the extrusion process. As a result, the APIs were distributed between the PSi and SOL phase after HME...
June 8, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28588251/fused-deposition-modeling-fdm-3d-printed-tablets-for-intragastric-floating-delivery-of-domperidone
#11
Xuyu Chai, Hongyu Chai, Xiaoyu Wang, Jingjing Yang, Jin Li, Yan Zhao, Weimin Cai, Tao Tao, Xiaoqiang Xiang
The aim of this study was to explore the feasibility of fused deposition modeling (FDM) 3D printing to prepare intragastric floating sustained release (FSR) tablets. Domperidone (DOM), an insoluble weak base, was chosen as a model drug to investigate the potential of FSR in increasing its oral bioavailability and reducing its administration frequency. DOM was successfully loaded into hydroxypropyl cellulose (HPC) filaments using hot melt extrusion (HME). The filaments were then printed into hollow structured tablets through changing the shell numbers and the infill percentages...
June 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28584898/factors-affecting-the-dissolution-of-indomethacin-solid-dispersions
#12
Wei Zhang, Chen-Ning Zhang, Yue He, Ban-Yan Duan, Guang-Yi Yang, Wei-Dong Ma, Yong-Hong Zhang
The aim of this study was to investigate the influence of factors such as carrier type, drug/carrier ratio, binary carriers, and preparation method on the dissolution of an insoluble drug, indomethacin (IM), under supersaturation conditions. Using a solvent evaporation (SE) method, poloxamer 188 and PVP K30 showed better dissolution among the selected carriers. Furthermore, as the ratio of carriers increased (drug/carrier ratio from 1:0.5 to 1:2), the dissolution rate increased especially in almost two times poloxamer 188 solid dispersions (SDs), while the reverse results were observed for PVP K30 SDs...
June 5, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28583588/processing-thermally-labile-drugs-by-hot-melt-extrusion-the-lesson-with-gliclazide
#13
Siyuan Huang, Kevin P O'Donnell, Sophie M Delpon de Vaux, John O'Brien, John Stutzman, Robert O Williams Iii
The formation of molecularly dispersed amorphous solid dispersions by the hot-melt extrusion technique relies on the thermal and mechanical energy inputs, which can cause chemical degradation of drugs and polymeric carriers. Additionally, drug degradation may be exacerbated as drugs convert from a more stable crystalline form to a higher energy amorphous form. Therefore, it is imperative to study how drug degrades and evaluate methods to minimize drug degradation during the extrusion process. In this work, gliclazide was used as a model thermally labile drug for the degradation kinetics and process optimization studies...
June 2, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28575936/solid-crystal-suspension-of-efavirenz-using-hot-melt-extrusion-exploring-the-role-of-crystalline-polyols-in-improving-solubility-and-dissolution-rate
#14
Jaywant N Pawar, Ritesh A Fule, Mohammed Maniruzzaman, Purnima D Amin
Poor aqueous solubility of drugs has emerged as a major issue for pharmaceutical scientists from many decades. The current study explores the manufacture and development of a thermodynamically stabilized solid crystal suspension (SCS) of poorly water soluble drug efavirenz via hot melt extrusion. Efavirenz is a non-nucleoside reverse transcriptase inhibitor and belongs to BCS class II. The SCS was prepared using pearlitol and xylitol as a crystalline carrier. The drug-excipient blend was processed by hot melt extrusion with up to 50% (w/w) drug loading...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28551152/global-approach-for-the-validation-of-an-in-line-raman-spectroscopic-method-to-determine-the-api-content-in-real-time-during-a-hot-melt-extrusion-process
#15
L Netchacovitch, J Thiry, C De Bleye, E Dumont, J Cailletaud, P-Y Sacré, B Evrard, Ph Hubert, E Ziemons
Since the Food and Drug Administration (FDA) published a guidance based on the Process Analytical Technology (PAT) approach, real-time analyses during manufacturing processes are in real expansion. In this study, in-line Raman spectroscopic analyses were performed during a Hot-Melt Extrusion (HME) process to determine the Active Pharmaceutical Ingredient (API) content in real-time. The method was validated based on a univariate and a multivariate approach and the analytical performances of the obtained models were compared...
August 15, 2017: Talanta
https://www.readbyqxmd.com/read/28549943/do-heat-and-moisture-exchangers-in-the-anaesthesia-breathing-circuit-preserve-body-temperature-in-dogs-undergoing-anaesthesia-for-magnetic-resonance-imaging
#16
Latifa Khenissi, Gwen Covey-Crump, Toby G Knowles, Joanna Murrell
OBJECTIVE: To investigate whether the use of a heat and moisture exchanger (HME) preserves body temperature in dogs weighing <10 kg anaesthetised for magnetic resonance imaging (MRI). STUDY DESIGN: Prospective, randomised, clinical trial. ANIMALS: Thirty-one client-owned dogs. METHODS: Dogs were assigned randomly to a treatment group [HME (n = 16) or no HME (n = 15)]. Dogs were pseudorandomised according to the premedication they were administered, either dexmedetomidine or no dexmedetomidine...
March 6, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28532677/predicting-melt-rheology-for-hot-melt-extrusion-by-means-of-a-simple-tg-measurement
#17
Esther S Bochmann, Elgin E Üstüner, Andreas Gryczke, Karl G Wagner
The feasibility of predicting melt rheology by using the glass transition temperature (Tg) of a desired amorphous solid dispersion (ASD) for hot-melt extrusion (HME) and other melt based processes is presented. Three groups of three different active pharmaceutical ingredients (APIs) or plasticizer/copovidone mixtures, with identical glass transition in rheological testing, were used. Their rheological behavior as a function of temperature and frequency were analyzed by means of small amplitude oscillatory shear (SAOS) on an oscillatory rheometer...
May 19, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28466453/hereditary-multiple-exostoses-new-insights-into-pathogenesis-clinical-complications-and-potential-treatments
#18
REVIEW
Maurizio Pacifici
PURPOSE OF REVIEW: Hereditary multiple exostoses (HME) is a complex musculoskeletal pediatric disorder characterized by osteochondromas that form next to the growth plates of many skeletal elements, including long bones, ribs, and vertebrae. Due to its intricacies and unresolved issues, HME continues to pose major challenges to both clinicians and biomedical researchers. The purpose of this review is to describe and analyze recent advances in this field and point to possible targets and strategies for future biologically based therapeutic intervention...
June 2017: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/28457353/tick-borne-emerging-infections-ehrlichiosis-and-anaplasmosis
#19
REVIEW
Nahed Ismail, Jere W McBride
Human ehrlichiosis and anaplasmosis are acute febrile tick-borne infectious diseases caused by various members from the genera Ehrlichia and Anaplasma. Ehrlichia chaffeensis is the major etiologic agent of human monocytotropic ehrlichiosis (HME), while Anaplasma phagocytophilum is the major cause of human granulocytic anaplasmosis (HGA). The clinical manifestations of HME and HGA ranges from subclinical to potentially life-threatening diseases associated with multi-organ failure. Macrophages and neutrophils are the major target cells for Ehrlichia and Anaplasma, respectively...
June 2017: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/28445472/unsuspected-osteochondroma-like-outgrowths-in-the-cranial-base-of-hereditary-multiple-exostoses-patients-and-modeling-and-treatment-with-a-bmp-antagonist-in-mice
#20
Sayantani Sinha, Christina Mundy, Till Bechtold, Federica Sgariglia, Mazen M Ibrahim, Paul C Billings, Kristen Carroll, Eiki Koyama, Kevin B Jones, Maurizio Pacifici
Hereditary Multiple Exostoses (HME) is a rare pediatric disorder caused by loss-of-function mutations in the genes encoding the heparan sulfate (HS)-synthesizing enzymes EXT1 or EXT2. HME is characterized by formation of cartilaginous outgrowths-called osteochondromas- next to the growth plates of many axial and appendicular skeletal elements. Surprisingly, it is not known whether such tumors also form in endochondral elements of the craniofacial skeleton. Here, we carried out a retrospective analysis of cervical spine MRI and CT scans from 50 consecutive HME patients that included cranial skeletal images...
April 2017: PLoS Genetics
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