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https://www.readbyqxmd.com/read/29326881/interaction-of-anthraquinones-of-cassia-occidentalis-seeds-with-dna-and-glutathione
#1
Gati Krushna Panigrahi, Neeraj Verma, Nivedita Singh, Somya Asthana, Shailendra K Gupta, Anurag Tripathi, Mukul Das
Consumption of Cassia occidentalis (CO) seeds has been associated with the hepatomyoencephalopathy (HME) in children. Recently, we have characterized the toxic anthraquinones (AQs) such as Emodin, Rhein, Aloe-emodin, Chrysophanol and Physcion in CO seeds and detected these moieties in the bio fluids of CO poisoning cases. As AQs were detected in the serum of HME patients, their interaction with key biomolecules including protein, DNA and glutathione (GSH) is imperative. In this regard, we have previously reported the interaction of these AQs with serum albumin protein and their subsequent biological effects...
2018: Toxicology Reports
https://www.readbyqxmd.com/read/29310491/influence-of-processing-methods-on-physico-mechanical-properties-of-ibuprofen-hpc-ssl-formulation
#2
Kaushalendra Chaturvedi, Bhavin Y Gajera, Ting Xu, Harsh Shah, Rutesh H Dave
The objective of the present study was to investigate the influence of processing methods on the physical and mechanical properties of formulations containing Ibuprofen and HPC-SSL. The powder blends, containing Ibuprofen and HPC-SSL in ratio of 9:0.5, were processed using melt granulation (MG) by hot melt extrusion (HME) and wet granulation (WG) by high shear mixer. Formulated granules and powder blends were compressed into round flat faced tablets using Riva Piccola tablet press. Differential scanning calorimetry (DSC) and X-ray powder diffraction (XRPD) studies proved that granulation process did not significantly alter the crystallinity of Ibuprofen, however particle density and flow properties were significantly improved...
January 9, 2018: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/29308593/application-of-hot-melt-extrusion-technology-in-immediate-release-abuse-deterrent-formulations
#3
Klaus Wening, Sebastian Schwier, Hans-J Stahlberg, Eric Galia
OBJECTIVE: Hot-melt extrusion (HME) technology has been used for manufacturing extended-release abuse-deterrent formulations (ADFs) of opioid-type analgesics with improved tamper-resistant properties. Our objective was to describe application of this technology to immediate-release (IR) ADFs. DESIGN: For development of a sample IR ADF (hydrocodone 10 mg/acetaminophen 325 mg) based on HME, feasibility studies were performed using different excipients. The formulation selected for further development was evaluated via in vitro test battery...
November 2017: Journal of Opioid Management
https://www.readbyqxmd.com/read/29299523/clinical-feasibility-study-of-protrach-dualcare-a-new-speaking-valve-with-heat-and-moisture-exchanger-for-tracheotomized-patients
#4
B J de Kleijn, C J van As-Brooks, J Wedman, B F A M van der Laan
Objective: The aim of this study was to evaluate the clinical feasibility of the ProTrach DualCare (Atos Medical, Hörby, Sweden), a device combining a hands-free speaking valve and a Heat and Moisture Exchanger (HME) for tracheotomized patients. Study Design: A non-randomized, prospective single center feasibility study. Methods: Sixteen adult tracheotomized patients were included. Participants were asked to test the DualCare for two weeks while continuing their normal activities...
December 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/29291415/design-and-evaluation-of-bi-layer-pump-tablet-of-flurbiprofen-solid-dispersion-for-zero-order-controlled-delivery
#5
Lizhen Cheng, Ting Li, Ling Dong, Xiaoyu Wang, Qiye Huo, Haoyu Wang, Zhujun Jang, Xinyu Shan, Weisan Pan, Xinggang Yang
In this study, a bi-layer osmotic pump tablet (OPT) of Flurbiprofen (FP) solid dispersions (SDs) was developed to increase the solubility of the poorly soluble drug and control drug release at a constant rate. Based on the thermodynamic properties investigation of the drug, the carrier and the calculation of the solubility parameters, the FP-SD was prepared by hot melt extrusion (HME) technique with the carrier of PVPVA64. Then central composite design-response surface methodology (CCD-RSM) was used to evaluate the influence of factors on the responses...
December 29, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29281825/somatic-mutations-activating-the-mtor-pathway-in-dorsal-telencephalic-progenitors-cause-a-continuum-of-cortical-dysplasias
#6
Alissa M D'Gama, Mollie B Woodworth, Amer A Hossain, Sara Bizzotto, Nicole E Hatem, Christopher M LaCoursiere, Imad Najm, Zhong Ying, Edward Yang, A James Barkovich, David J Kwiatkowski, Harry V Vinters, Joseph R Madsen, Gary W Mathern, Ingmar Blümcke, Annapurna Poduri, Christopher A Walsh
Focal cortical dysplasia (FCD) and hemimegalencephaly (HME) are epileptogenic neurodevelopmental malformations caused by mutations in mTOR pathway genes. Deep sequencing of these genes in FCD/HME brain tissue identified an etiology in 27 of 66 cases (41%). Radiographically indistinguishable lesions are caused by somatic activating mutations in AKT3, MTOR, and PIK3CA and germline loss-of-function mutations in DEPDC5, NPRL2, and TSC1/2, including TSC2 mutations in isolated HME demonstrating a "two-hit" model...
December 26, 2017: Cell Reports
https://www.readbyqxmd.com/read/29277722/the-pathogenic-roles-of-heparan-sulfate-deficiency-in-hereditary-multiple-exostoses
#7
REVIEW
Maurizio Pacifici
Heparan sulfate (HS) is an essential component of cell surface and matrix proteoglycans (HS-PGs) that include syndecans and perlecan. Because of their unique structural features, the HS chains are able to specifically interact with signaling proteins -including bone morphogenetic proteins (BMPs)- via their HS-binding domain, regulating protein availability, distribution and action on target cells. Hereditary Multiple Exostoses (HME) is a rare pediatric disorder linked to germline heterozygous loss-of-function mutations in EXT1 or EXT2 that encode Golgi-resident glycosyltransferases responsible for HS synthesis, resulting in a systemic HS deficiency...
December 22, 2017: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29225745/heated-wire-humidification-circuit-attenuates-the-decrease-of-core-temperature-during-general-anesthesia-in-patients-undergoing-arthroscopic-hip-surgery
#8
Sooyong Park, Seok-Hwa Yoon, Ann Misun Youn, Seung Hyun Song, Ja Gyung Hwang
Background: Intraoperative hypothermia is common in patients undergoing general anesthesia during arthroscopic hip surgery. In the present study, we assessed the effect of heating and humidifying the airway with a heated wire humidification circuit (HHC) to attenuate the decrease of core temperature and prevent hypothermia in patients undergoing arthroscopic hip surgery under general anesthesia. Methods: Fifty-six patients scheduled for arthroscopic hip surgery were randomly assigned to either a control group using a breathing circuit connected with a heat and moisture exchanger (HME) (n = 28) or an HHC group using a heated wire humidification circuit (n = 28)...
December 2017: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/29221654/numerical-simulation-of-hot-melt-extrusion-processes-for-amorphous-solid-dispersions-using-model-based-melt-viscosity
#9
Esther S Bochmann, Kristina E Steffens, Andreas Gryczke, Karl G Wagner
Simulation of HME processes is a valuable tool for increased process understanding and ease of scale-up. However, the experimental determination of all required input parameters is tedious, namely the melt rheology of the amorphous solid dispersion (ASD) in question. Hence, a procedure to simplify the application of hot-melt extrusion (HME) simulation for forming amorphous solid dispersions (ASD) is presented. The commercial 1D simulation software Ludovic® was used to conduct (i) simulations using a full experimental data set of all input variables including melt rheology and (ii) simulations using model-based melt viscosity data based on the ASDs glass transition and the physical properties of polymeric matrix only...
December 5, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29217471/3d-printing-of-high-drug-loaded-dosage-forms-using-thermoplastic-polyurethanes
#10
G Verstraete, A Samaro, W Grymonpré, V Vanhoorne, B Van Snick, M N Boone, T Hellemans, L Van Hoorebeke, J P Remon, C Vervaet
It was the aim of this study to develop high drug loaded (>30%, w/w), thermoplastic polyurethane (TPU)-based dosage forms via fused deposition modelling (FDM). Model drugs with different particle size and aqueous solubility were pre-processed in combination with diverse TPU grades via hot melt extrusion (HME) into filaments with a diameter of 1.75 ± 0.05 mm. Subsequently, TPU-based filaments which featured acceptable quality attributes (i.e. consistent filament diameter, smooth surface morphology and good mechanical properties) were printed into tablets...
December 4, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29205040/a-new-method-of-constructing-drug-polymer-temperature-composition-phase-diagram-relevant-to-the-hot-melt-extrusion-platform
#11
Yiwei Tian, David S Jones, Conor Donnelly, Timothy Brannigan, Shu Li, Gavin P Andrews
Current experimental methodologies used to determine the thermodynamic solubility of an API within a polymer typically involves establishing the dissolution/melting endpoint of the crystalline API within a physical mixture, or through the use of the glass transition temperature measurement of a de-mixed amorphous solid dispersion. The measurable "equilibrium" points for solubility are normally well above the glass transition temperature of the system meaning extrapolation is required in order to predict the drug solubility at pharmaceutical relevant temperatures...
December 5, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29191485/impact-of-non-binder-ingredients-and-molecular-weight-of-polymer-binders-on-heat-assisted-twin-screw-dry-granulation
#12
Y Liu, M R Thompson, K P O'Donnell
Two grades of commercial AFFINISOL™ HPMC HME were used as polymer binders to explore the influence of polymer viscosity and concentration on a novel heat assisted dry granulation process with a twin screw extruder. Contributions of other non-binder ingredients in the formulations were also studied for lactose, microcrystalline cellulose and an active pharmaceutical ingredient of caffeine. As sensitive indicators of processing conditions that expose the drug to high internally generated heat, dehydration of α-lactose monohydrate and polymorphic transformation of caffeine were monitored by differential scanning calorimetry (DSC) and powder X-ray diffraction (XRD)...
November 27, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29166563/mechanochemical-synthesis-of-pharmaceutical-cocrystal-suspensions-via-hot-melt-extrusion-enhancing-cocrystal-yield
#13
Shu Li, Tao Yu, Yiwei Tian, Colette Lagan, David S Jones, Gavin P Andrews
Pharmaceutical cocrystals have attracted increasing attention over the past decade as an alternative way to modify the physicochemical properties and hence improve the bioavailability of a drug, without sacrificing thermodynamic stability. Our previous work has demonstrated the viability of in-situ formation of ibuprofen/isonicotinamide cocrystal suspensions within a matrix carrier via a single-step hot-melt extrusion (HME) process. The key aim of the current work is to establish optimised processing conditions to improve cocrystal yield within extruded matrices...
November 22, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29145995/plga-based-monolithic-filaments-prepared-by-hot-melt-extrusion-in-vitro-comparative-study
#14
R Kamel, H Abbas
To avoid frequent drug administration, PLGA-based monolithic filament-shaped implants were prepared. In this study, the effect of different formulation variables was studied, namely: type of PLGA (PLGA 502 and PLGA 503), type of drug (the lipophilic Prednisolone acetate, PA and the hydrophilic Propranolol Hydrochloride, PH) and drug loading (10 and 30% w/w). PLGA 503-based implants showed a lower water uptake, lower mass loss and erosion, slower drug release, and better mechanical properties and elasticity (P<0...
November 13, 2017: Annales Pharmaceutiques Françaises
https://www.readbyqxmd.com/read/29136137/copy-number-variation-and-expression-analysis-reveals-a-non-orthologous-pinta-gene-family-member-involved-in-butterfly-vision
#15
Aide Macias-Muñoz, Kyle J McCulloch, Adriana D Briscoe
Vertebrate (CRALBP) and Drosophila (PINTA) proteins with a CRAL-TRIO domain transport retinal-based chromophores that bind to opsin proteins and are necessary for phototransduction. The CRAL-TRIO domain gene family is composed of genes that encode proteins with a common N-terminal structural domain. While there is an expansion of this gene family in Lepidoptera, there is no lepidopteran ortholog of pinta. Further, the function of these genes in lepidopterans has not yet been established. Here we explored the molecular evolution and expression of CRAL-TRIO domain genes in the butterfly Heliconius melpomene in order to identify a member of this gene family as a candidate chromophore transporter...
November 9, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/29128951/insights-from-the-genomes-of-microbes-thriving-in-uranium-enriched-sediments
#16
Brodie Sutcliffe, Anthony A Chariton, Andrew J Harford, Grant C Hose, Sarah Stephenson, Paul Greenfield, David J Midgley, Ian T Paulsen
Elevated uranium dose (4 g kg(-1)) causes a shift in billabong sediment communities that result in the enrichment of five bacterial species. These taxa include Geobacter, Geothrix and Dyella species, as well as a novel-potentially predatory-Bacteroidetes species, and a new member of class Anaerolineae (Chloroflexi). Additionally, a population of methanogenic Methanocella species was also identified. Genomic reconstruction and metabolic examination of these taxa reveal a host of divergent life strategies and putative niche partitioning...
November 11, 2017: Microbial Ecology
https://www.readbyqxmd.com/read/29127610/pvp-va64-as-a-novel-release-modifier-for-sustained-release-mini-matrices-prepared-via-hot-melt-extrusion
#17
Yongcheng Li, Ming Lu, Chuanbin Wu
The purpose of this study was to explore poly(vinylpyrrolidone-co-vinyl acetate) (PVP VA64) as a novel release-modifier to tailor the drug release from ethylcellulose (EC)-based mini-matrices prepared via hot melt extrusion (HME). Quetiapine fumarate (QF) was selected as model drug. QF/EC/PVP VA64 mini-matrices were extruded with 30% drug loading. The physical state of QF in extruded mini-matrices was characterized using differential scanning calorimetry, X-ray powder diffraction, and confocal Raman microscopy...
November 10, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29126381/a-genotype-phenotype-study-of-hereditary-multiple-exostoses-in-forty-six-chinese-patients
#18
Yuchan Li, Jian Wang, Zhigang Wang, Jingyan Tang, Tingting Yu
BACKGROUND: Hereditary multiple exostoses (HME) is a rare autosomal dominant skeletal disorder that can cause a variety of clinical manifestations. We aimed to evaluate the general clinical phenotypic severity of HME by using a scoring system and correlate the genotypes with different clinical phenotypes in Chinese patients. METHODS: Forty-six patients from different families were prospectively enrolled. The mutations were identified by direct sequencing of PCR-amplified genomic DNA or by multiplex ligation-dependent probe amplification (MLPA)...
November 10, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/29113803/demonstration-of-pharmaceutical-tablet-coating-process-by-injection-molding-technology
#19
Vibha Puri, David Brancazio, Eranda Harinath, Alexander R Martinez, Parind M Desai, Keith D Jensen, Jung-Hoon Chun, Richard D Braatz, Allan S Myerson, Bernhardt L Trout
We demonstrate the coating of tablets using an injection molding (IM) process that has advantage of being solvent free and can provide precision coat features. The selected core tablets comprising 10% w/w griseofulvin were prepared by an integrated hot melt extrusion-injection molding (HME-IM) process. Coating trials were conducted on a vertical injection mold machine. Polyethylene glycol and polyethylene oxide based hot melt extruded coat compositions were used. Tablet coating process feasibility was successfully demonstrated using different coating mold designs (with both overlapping and non-overlapping coatings at the weld) and coat thicknesses of 150 and 300 μm...
November 4, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29102700/melt-extrusion-with-poorly-soluble-drugs-an-integrated-review
#20
Michael A Repka, Suresh Bandari, Venkata Raman Kallakunta, Anh Q Vo, Haley McFall, Manjeet B Pimparade, Ajinkya M Bhagurkar
Over the last few decades, hot melt extrusion (HME) has emerged as a successful technology for a broad spectrum of applications in the pharmaceutical industry. As indicated by multiple publications and patents, HME is mainly used for the enhancement of solubility and bioavailability of poorly soluble drugs. This review is focused on the recent reports on the solubility enhancement via HME and provides an update for the manufacturing/scaling up aspects of melt extrusion. In addition, drug characterization methods and dissolution studies are discussed...
November 2, 2017: International Journal of Pharmaceutics
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