keyword
https://read.qxmd.com/read/38546502/modulation-of-al-distribution-in-high-silica-zsm-5-zeolites-for-enhancing-catalytic-performance
#1
JOURNAL ARTICLE
Liang Zhao, Pei-Pei Xiao, Yong Wang, Yao Lu, Tahta Muslim Karim, Hermann Gies, Toshiyuki Yokoi
The spatial distribution of framework Al (AlF ) has been one of the important factors that affect the catalytic properties of zeolites in diverse chemical reactions; however, the synthesis of high-silica zeolites with special AlF distribution remains a challenge. In this study, we successfully synthesized high-silica ZSM-5 zeolites with a unique AlF distribution by employing pentaerythritol (PET) as an additive in the presence of a few tetrapropylammonium hydroxide (TPAOH). The results demonstrated that the introduction of PET led to a higher proportion of Al atoms located at the sinusoidal and/or straight channels...
March 28, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38542043/real-world-experience-with-brolucizumab-compared-to-aflibercept-in-treatment-na%C3%A3-ve-and-therapy-refractory-patients-with-diabetic-macular-edema
#2
JOURNAL ARTICLE
Anne Rübsam, Leopold Hössl, Saskia Rau, Alexander Böker, Oliver Zeitz, Antonia M Joussen
Background : To report on the outcome of intravitreal brolucizumab compared to aflibercept in patients with diabetic macular edema (DME). Methods : Prospective, observational, study in 35 eyes of 24 patients with a loading dose of five injections of 6 mg brolucizumab every 6 weeks (q6w, treatment-naïve eyes) or a minimum of two injections of brolucizumab q6w after the switch (recalcitrant DME eyes), followed by a treat and extend (T&E) regimen. The results were compared with 40 eyes of 31 DME patients who were treated with aflibercept...
March 21, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541760/sustained-disease-control-in-dme-patients-upon-treatment-cessation-with-brolucizumab
#3
JOURNAL ARTICLE
Justus G Garweg, Sonja Steinhauer
Background: Treatment cessation due to a dry retina has not been systematically addressed in diabetic macular edema (DME). In three out of four patients receiving 6 mg of brolucizumab in the KITE study, treatment was terminated after the study ended. Methods: The KITE study was a double-masked, multicenter, active-controlled, randomized trial (NCT03481660) in DME patients. Per protocol, patients received five loading injections of Brolucizumab at 6-week intervals, with the option to adjust to 8 weeks in case of disease activity or to extend in the second year to a maximum of 16 weeks in the absence of retinal fluid...
March 7, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38538293/effect-of-intravitreal-aflibercept-on-corneal-endothelial-cells
#4
JOURNAL ARTICLE
Zuzana Šulavíková, Zuzana Šustykevičová, Marek Káčerik, Vladimír Krásnik
AIM:  To determine the effect of repeated intravitreal injections of aflibercept on the corneal endothelium in patients with diabetic macular edema (DME) and macular edema due to retinal vein occlusion (RVO). METHODS:  In a prospective study conducted between January 2021 and November 2023, a total of 87 treatment-naive eyes with DME and RVO were evaluated. The exclusion criteria were surgery or laser intervention during the follow-up period, contact lens wear, cataract surgery in the last 6 months, dystrophy, or other corneal condition that may cause endothelial damage...
2024: Ceská a Slovenská Oftalmologie
https://read.qxmd.com/read/38537425/real-world-safety-of-levetiracetam-mining-and-analysis-of-its-adverse-drug-reactions-based-on-faers-database
#5
JOURNAL ARTICLE
Zhimin He, Cuimin Liu, Lin Lin, Guowen Feng, Gang Wu
INTRODUCTION: Levetiracetam is a relatively new and widely utilized anti-seizure medication; however, limited information is available regarding its adverse effects. This study aims to thoroughly investigate, evaluate, and present evidence on the safety profile of Levetiracetam, relying on data from the FDA Adverse Event Reporting System (FAERS) database to facilitate informed clinical decision-making. METHODS: We employed various statistical measures, including Reporting Odds Ratio (ROR), Proportionate Reporting Ratio (PRR), and analysis by the Medicines and Healthcare Products Regulatory Agency (MHRA), to identify signals of adverse reactions associated with Levetiracetam...
March 21, 2024: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/38530567/enhancing-diabetic-macular-edema-treatment-outcomes-exploring-the-esaso-classification-and-structural-oct-biomarkers
#6
JOURNAL ARTICLE
Giacomo Panozzo, Maria V Cicinelli, Giulia Dalla Mura, Diana Giannarelli, Maria Vadalà, Vincenza Bonfiglio, Giovanni Bellisario, Francesco Bandello
INTRODUCTION: This study assessed the European School of Advanced Studies in Ophthalmology (ESASO) classification's prognostic value for diabetic macular edema (DME) in predicting intravitreal therapy outcomes. METHODS: In this retrospective, multicenter study, patients aged > 50 years with type 1 or 2 diabetes and DME received intravitreal antivascular endothelial growth factor (anti-VEGF) agents (ranibizumab, bevacizumab, and aflibercept) or steroids (dexamethasone)...
March 26, 2024: Ophthalmology and Therapy
https://read.qxmd.com/read/38530451/the-longitudinal-follow-up-of-a-newly-proposed-octa-imaging-finding-sspim-and-the-importance-of-it-as-a-new-biomarker-for-treatment-response-in-diabetic-macular-edema
#7
JOURNAL ARTICLE
Gülsüm Genç, Özge Yanık, Sibel Demirel, Figen Batioglu, Emin Özmert
PURPOSE: This study aimed to evaluate the frequency of SSPiM (suspended scattering particles in motion), systemic risk factors, ocular findings, progression characteristics, and treatment response in diabetic retinopathy (DR) patients. METHODS: In this prospective study, a total of 109 eyes of 109 patients with diabetic macular edema (DME) were included. Demographic characteristics and systemic data of the patients were recorded. In addition to a detailed ophthalmological examination, optical coherence tomography (OCT) and OCT angiography (OCTA) imaging were performed...
March 26, 2024: Graefe's Archive for Clinical and Experimental Ophthalmology
https://read.qxmd.com/read/38529446/topical-dorzolamide-as-adjunctive-treatment-with-intravitreal-bevacizumab-in-bilateral-diabetic-macular-edema
#8
JOURNAL ARTICLE
Ata Sadr, Meisam Sargazi, Shahram Banaie, Mahdi Asani, Hassan Mehrad Majd, Seyed Omid Mohammadi, Alireza Maleki
BACKGROUND:  Intravitreal injection of anti-vascular endothelial growth factor (VEGF) agents is accepted as the gold standard treatment for center-involving diabetic macular edema (CI-DME). Adjunctive administration of topical dorzolamide may enhance the therapeutic effects of anti-VEGF agents. In this study, we compared the efficacy of topical dorzolamide plus intravitreal injection of bevacizumab (IVB) versus IVB alone in patients with bilateral DME. METHODS: This prospective, randomized contralateral eye study was carried out in a tertiary referral ophthalmology center, Al-Zahra Eye Hospital, Zahedan, Iran, between April 2021 and April 2022...
February 2024: Curēus
https://read.qxmd.com/read/38525063/theoretical-study-on-the-role-of-magnesium-chloride-complexes-induced-by-different-magnesium-to-chlorine-ratios-in-magnesium-sulfur-batteries
#9
JOURNAL ARTICLE
Xiaoli Jiang, Panyu Zhang, Liyuan Jiang, Xinxin Zhao, Jianbao Wu
In magnesium-sulfur batteries, electrolyte exploration is vital for developing high-energy-density, safe, and reliable batteries. This study focused on cyclic THF and chain DME, representative solvents in ether electrolytes. MgCl2 , an ideal anionic salt, forms mono-nuclear (MgCl2 (DME)2 ), bi-nuclear ([Mg2 (μ-Cl)2 (DME)4 ]2+ ), and tri-nuclear ([Mg3 (μ-Cl)4 (DME)5 ]2+ ) complexes in DME. With increasing salt concentration, these complexes sequentially form. Under lower salt concentrations, THF and MgCl2 form mono-nuclear complexes ([MgCl2 (THF)4 ]) and continue to form bi-nuclear complexes ([Mg2 (μ-Cl)3 (THF)6 ]+ )...
March 20, 2024: RSC Advances
https://read.qxmd.com/read/38524319/phacoemulsification-in-patients-with-diabetic-macular-edema-a-real-world-data-of-75-eyes
#10
JOURNAL ARTICLE
Shikha Talwar Bassi, Shebin Salim, Ekta Rishi
PURPOSE: The purpose of this study was to evaluate the outcomes of phacoemulsification with intravitreal triamcinolone acetonide (IVTA) injection in patients with cataract and diabetic macular edema (DME) across the grades of diabetic retinopathy (DR). MATERIALS AND METHODS: It was a retrospective observational study. The study included 70 patients (75 eyes) with cataract and clinically significant macular edema in diabetics with nonproliferative (61 eyes) or proliferative (14 eyes) DR who underwent phacoemulsification with IVTA...
2024: Oman Journal of Ophthalmology
https://read.qxmd.com/read/38523956/innovations-in-diabetic-macular-edema-management-a-comprehensive-review-of-automated-quantification-and-anti-vascular-endothelial-growth-factor-intervention
#11
REVIEW
Soumya Sharma, Sachin Daigavane, Pranaykumar Shinde
Diabetic macular edema (DME) poses a significant threat to the vision and quality of life of individuals with diabetes. This comprehensive review explores recent advancements in DME management, focusing on integrating automated quantification techniques and anti-vascular endothelial growth factor (anti-VEGF) interventions. The review begins with an overview of DME, emphasizing its prevalence, impact on diabetic patients, and current challenges in management. It then delves into the potential of automated quantification, leveraging machine learning and artificial intelligence to improve early detection and monitoring...
February 2024: Curēus
https://read.qxmd.com/read/38523129/the-incidence-and-prevalence-of-diabetic-macular-edema-and-proliferative-diabetic-retinopathy-their-progression-to-visual-impairment-and-patterns-in-their-intravitreal-treatment-in-the-finnish-population
#12
JOURNAL ARTICLE
Hanna Heloterä, Martti Arffman, Reijo Sund, Ilmo Keskimäki, Kai Kaarniranta
PURPOSE: The worldwide prevalence of diabetes mellitus (DM) continues to increase. As DM is linked to various ophthalmological comorbidities, it is crucial to understand the incidence and the treatment patterns of these complications to minimise the treatment burden for the patient and the healthcare system. This study aims to evaluate the incidence and prevalence of diabetic macular oedema (DME) and proliferative diabetic retinopathy (PDR) and to analyse intravitreal (IVT) treatment patterns and responses in the Finnish population with diabetes...
March 24, 2024: Acta Ophthalmologica
https://read.qxmd.com/read/38521818/self-supervised-category-selective-attention-classifier-network-for-diabetic-macular-edema-classification
#13
JOURNAL ARTICLE
Sachin Chavan, Nitin Choubey
AIMS: This study aims to develop an advanced model for the classification of Diabetic Macular Edema (DME) using deep learning techniques. Specifically, the objective is to introduce a novel architecture, SSCSAC-Net, that leverages self-supervised learning and category-selective attention mechanisms to improve the precision of DME classification. METHODS: The proposed SSCSAC-Net integrates self-supervised learning to effectively utilize unlabeled data for learning robust features related to DME...
March 23, 2024: Acta Diabetologica
https://read.qxmd.com/read/38521424/optical-coherence-tomography-angiography-in-diabetic-retinopathy-a-major-review
#14
REVIEW
Hosein Nouri, Seyed-Hossein Abtahi, Mehdi Mazloumi, Sanam Samadikhadem, J Fernando Arevalo, Hamid Ahmadieh
Diabetic retinopathy (DR) is characterized by retinal vasculopathy and is a leading cause of visual impairment. Optical coherence tomography angiography (OCTA) is an innovative imaging technology that can detect various pathologies and quantifiable changes in retinal microvasculature. We briefly describe its functional principles and advantages over fluorescein angiography and perform a comprehensive review on its clinical applications in the screening or management of people with prediabetes, diabetes without clinical retinopathy (NDR), nonproliferative DR (NPDR), proliferative DR (PDR), and diabetic macular edema (DME)...
March 21, 2024: Survey of Ophthalmology
https://read.qxmd.com/read/38517913/explainable-ensemble-learning-method-for-oct-detection-with-transfer-learning
#15
JOURNAL ARTICLE
Jiasheng Yang, Guanfang Wang, Xu Xiao, Meihua Bao, Geng Tian
The accuracy and interpretability of artificial intelligence (AI) are crucial for the advancement of optical coherence tomography (OCT) image detection, as it can greatly reduce the manual labor required by clinicians. By prioritizing these aspects during development and application, we can make significant progress towards streamlining the clinical workflow. In this paper, we propose an explainable ensemble approach that utilizes transfer learning to detect fundus lesion diseases through OCT imaging. Our study utilized a publicly available OCT dataset consisting of normal subjects, patients with dry age-related macular degeneration (AMD), and patients with diabetic macular edema (DME), each with 15 samples...
2024: PloS One
https://read.qxmd.com/read/38508440/application-of-optical-coherence-tomography-angiography-in-the-assessment-of-diabetic-macular-edema-staging-and-laser-photocoagulation-efficacy
#16
JOURNAL ARTICLE
Wei-Na Fu, Yan Du, Zhi-Yong Gong
OBJECTIVE: This study aimed to analyze the effect of optical coherence tomography angiography (OCTA) on diabetic macular edema (DME) staging and assess the efficacy of laser photocoagulation. METHODS: Eighty-six patients (141 eyes) with suspected DME who visited our hospital from August 2019 to March 2022 were selected and underwent fundus angiography and OCTA. The two examination methods were compared in terms of their efficacy in macular edema staging. Subsequently, the sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of OCTA in diagnosing DME were assessed using fundus angiography as the gold standard...
March 18, 2024: Photodiagnosis and Photodynamic Therapy
https://read.qxmd.com/read/38505256/the-economic-burden-of-diabetic-retinopathy-in-jordan-cost-analysis-and-associated-factors
#17
JOURNAL ARTICLE
Rami A Al-Dwairi, Abdelwahab Aleshawi, Laith Abu-Zreig, Wafa Al-Shorman, Seren Al Beiruti, Ali Omar Alshami, Mohammed Z Allouh
OBJECTIVE: Diabetic retinopathy (DR) is the leading cause of visual loss worldwide in patients with diabetes mellitus (DM). The aims of our study are to describe the costs associated with (DR) and to evaluate its economic impact in Jordan. METHODS: Retrospectively, we included all patients with DM and classified them according to the severity of DR. Data regarding medical history, ophthalmic history, stage of DR, presence of DME, and the ophthalmic procedures and operations were collected...
2024: ClinicoEconomics and Outcomes Research: CEOR
https://read.qxmd.com/read/38502000/investigating-steric-and-electronic-effects-in-the-synthesis-of-square-planar-6d-1-th-iii-complexes
#18
JOURNAL ARTICLE
Joseph Q Nguyen, Justin C Wedal, Joseph W Ziller, Filipp Furche, William J Evans
The factors affecting the formation and crystal structures of unusual 6d1 Th(III) square planar aryloxide complexes, as exemplified by [Th(OArMe )4 ]1- (OArMe = OC6 H2 t Bu2 -2,6-Me-4), were explored by synthetic and reduction studies of a series of related Th(IV) tetrakis(aryloxide) complexes, Th(OArR )4 (OArR = OC6 H2 t Bu2 -2,6-R-4). Specifically, electronic, steric, and countercation effects were explored by varying the aryloxide ligand, the alkali metal reducing agent, and the alkali metal chelating agent...
March 19, 2024: Inorganic Chemistry
https://read.qxmd.com/read/38498352/solution-and-solid-state-characterization-of-rare-silyluranium-iii-complexes
#19
JOURNAL ARTICLE
Nathan J Lin, Matthias Zeller, Suzanne C Bart
A uranium(III) silylate complex [K(DME)4 ][UI2 {(Si(SiMe3 )2 SiMe2 )2 O}] (1) was stabilized by the addition of 18-crown-6, forming [K(18-crown-6)][UI2 {(Si(SiMe3 )2 SiMe2 )2 O}] (1-crown). Crystallization under multiple conditions resulted in three distinct molecular structures. Compound 1-crown was further characterized in the solution state via 1 H, 13 C, and 29 Si NMR spectroscopy, and electronic absorption spectroscopy.
March 18, 2024: Chemical Communications: Chem Comm
https://read.qxmd.com/read/38496154/is-intravitreal-injection-of-recombinant-tissue-plasminogen-activator-effective-for-the-treatment-of-refractory-diabetic-macular-edema-in-patients-with-posterior-vitreous-detachment
#20
JOURNAL ARTICLE
Şule Berk Ergun, Yasin Toklu, Mücella Arıkan Yorgun, Melek Mutlu Sönmez, Hasan B Arifoğlu, Hasan B Çakmak
OBJECTIVE: To determine whether intravitreal injection of recombinant tissue plasminogen activator (rTPA) is effective for the treatment of refractory diabetic macular edema (DME) in patients who already had posterior vitreous detachment (PVD). METHODS: It is a retrospective chart review of the patients with refractory DME and PVD. The efficacy of intravitreal injection of rTPA was assessed based on the changes in central macular thickness (CMT) and best-corrected visual acuity (BCVA) in these patients...
February 2024: Curēus
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