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https://www.readbyqxmd.com/read/28819567/systemic-associations-with-residual-subretinal-fluid-after-ranibizumab-in-diabetic-macular-edema
#1
Meng-Ju Tsai, Yi-Ting Hsieh, Elizabeth P Shen, Yi-Jie Peng
PURPOSE: To investigate the impact of systemic diseases on the occurrence of subretinal fluid (SRF) in diabetic macular edema (DME) and prognostic factors for residual SRF following three consecutive monthly intravitreal ranibizumab. METHODS: Ninety-seven eyes from 68 patients with DME who completed 3 consecutive monthly injections of ranibizumab were enrolled. Systemic parameters mainly included chronic kidney disease (CKD), hypertension, HbA1c, and insulin dependence...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28814412/long-term-outcomes-with-as-needed-aflibercept-in-diabetic-macular-oedema-2-year-outcomes-of-the-endurance-extension-study
#2
Charles C Wykoff, William C Ou, Rahul N Khurana, David M Brown, W Lloyd Clark, David S Boyer
BACKGROUND/AIMS: To evaluate the efficacy and safety of individualised 2.0 mg intravitreal aflibercept retreatment for diabetic macular oedema (DME) through the fifth year of management. METHODS: This is a phase IV, 2-year, open-label extension study. Sixty patients completing the 3-year VISTA DME (Study of Intravitreal Aflibercept Injection in Patients With Diabetic Macular Edema) phase III trial enrolled in the ENDURANCE (Long-Term Efficacy and Safety of Intravitreal Aflibercept for the Treatment of DME in Subjects Who Completed the VISTA DME Trial) extension study...
August 16, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28808926/foveal-microstructure-analysis-in-eyes-with-diabetic-macular-edema-treated-with-vitrectomy
#3
Jiro Kogo, Akira Shiono, Hiroki Sasaki, Ryo Yomoda, Tatsuya Jujo, Yasushi Kitaoka, Hitoshi Takagi
INTRODUCTION: The purpose of this study was to evaluate baseline and postoperative factors affecting outcomes after vitrectomy for diabetic macular edema (DME) using optical coherence tomography (OCT). METHODS: Vitrectomy combined with inner limiting membrane (ILM) peeling and additional laser photocoagulation therapy was performed on 36 eyes of 30 DME patients. Evaluations included the logarithm of the minimal angle of resolution (logMAR), best-corrected visual acuity (BCVA) and OCT parameters at baseline and 1, 3, 6, and 12 months postoperatively...
August 14, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28808662/the-status-of-maculopathy-in-diabetes-and-prediabetes-patients-in-a-population-based-study-detected-by-optical-coherence-tomography-the-2011-health-examination-survey-in-beijing
#4
Xi Cao, Zhong Xin, Shiming Li, Yue Qi, Mingxia Yuan, Xiaorong Zhu, Jin-Kui Yang
OBJECTIVE: The aim of the study was to investigate the prevalence and the risk factors of maculopathy detected by optical coherence tomography (OCT) in a Chinese population with diabetes or prediabetes. Methods. 8,155 people were randomly selected to participate in the 2011 annual Health Examination Survey in Beijing. A 75 g oral glucose tolerance test (OGTT) was tested in 3760 subjects with fasting plasma glucose (FPG) ≥ 5.6 mmol/L. Of 3,760 subjects, 583 were also randomly selected to take OCT...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28808641/management-of-large-class-ii-lesions-in-molars-how-to-restore-and-when-to-perform-surgical-crown-lengthening
#5
Ana Belén Dablanca-Blanco, Juan Blanco-Carrión, Benjamín Martín-Biedma, Purificación Varela-Patiño, Alba Bello-Castro, Pablo Castelo-Baz
The restoration of endodontic tooth is always a challenge for the clinician, not only due to excessive loss of tooth structure but also invasion of the biological width due to large decayed lesions. In this paper, the 7 most common clinical scenarios in molars with class II lesions ever deeper were examined. This includes both the type of restoration (direct or indirect) and the management of the cavity margin, such as the need for deep margin elevation (DME) or crown lengthening. It is necessary to have the DME when the healthy tooth remnant is in the sulcus or at the epithelium level...
August 2017: Restorative Dentistry & Endodontics
https://www.readbyqxmd.com/read/28803804/effect-of-esthetic-coating-on-surface-roughness-of-orthodontic-archwires
#6
Seyed Mohammad Mousavi, Milad Shamohammadi, Zahra Rastegaar, Masoumeh Skini, Vahid Rakhshan
BACKGROUND AND AIM: Esthetic wires are commonly used in orthodontic treatments. Surface roughness is an important factor in the friction and bacterial adhesion in these wires. Surface roughness of esthetic wires has not been assessed, except in a few recent (mostly qualitative esthetics) studies. The aim of this study was to quantitatively compare the surface roughness of 4 coated esthetic wires with that of a conventional orthodontic wire. MATERIALS AND METHODS: In this in vitro trial, 25 coated and uncoated orthodontic archwires were studied, including: NiTi Memory wire (American Orthodontics, USA) as a control group; Orthocosmetic Elastinol (Ortho Organizers, USA); Perfect (Hubit, Korea); Imagination (Gestenco, Sweden); EverWhite (American Orthodontics, USA)...
August 10, 2017: International Orthodontics
https://www.readbyqxmd.com/read/28796876/the-distribution-of-leakage-on-fluorescein-angiography-in-diabetic-macular-edema-a-new-approach-to-its-etiology
#7
Bilal Haj Najeeb, Christian Simader, Gabor Deak, Clemens Vass, Jutta Gamper, Alessio Montuoro, Bianca S Gerendas, Ursula Schmidt-Erfurth
Purpose: To determine the distribution of leakage on fluorescein angiography (FA) and explore the clinically protective role of astrocytes against damage to the inner blood retinal barrier (iBRB) in diabetic macular edema (DME). Methods: A consecutive case series of 87 eyes of 87 patients with DME was included. We measured the leakage area in each field of the Early Treatment Diabetic Retinopathy Study (ETDRS) grid on late-phase FA images. The normative thickness of the nerve fiber layer (NFL), in which the astrocytes are confined, was derived from a previous work using spectral-domain optical coherence tomography...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28783619/fully-automated-segmentation-of-fluid-cyst-regions-in-optical-coherence-tomography-images-with-diabetic-macular-edema-using-neutrosophic-sets-and-graph-algorithms
#8
Abdolreza Rashno, Dara D Koozekanani, Paul M Drayna, Behzad Nazari, Saeed Sadri, Hossein Rabbani, Keshab K Parhi
This paper presents a fully-automated algorithm to segment fluid-associated (fluid-filled) and cyst regions in optical coherence tomography (OCT) retina images of the subjects with diabetic macular edema (DME). The OCT image is segmented using a novel neutrosophic transformation and a graph-based shortest path method. In neutrosophic domain, an image g is transformed into three sets: T (true), I (indeterminate) that represents noise, and F (false). This paper makes four key contributions. First, a new method is introduced to compute the indeterminacy set I, and a new λ-correction operation is introduced to compute the set T in neutrosophic domain...
July 31, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28764888/baseline-factors-affecting-changes-in-diabetic-retinopathy-severity-scale-score-after-intravitreal-aflibercept-or-laser-for-diabetic-macular-edema-post-hoc-analyses-from-vista-and-vivid
#9
Dilsher S Dhoot, Keith Baker, Namrata Saroj, Robert Vitti, Alyson J Berliner, Carola Metzig, Desmond Thompson, Rishi P Singh
PURPOSE: To evaluate whether select baseline systemic and ocular factors influence ≥2-step improvement in the Diabetic Retinopathy Severity Scale (DRSS) score at week 100 in VISTA and VIVID. DESIGN: Post hoc analysis of 2 similarly designed phase 3 trials, VISTA and VIVID. PARTICIPANTS: Total of 456 patients with center-involved diabetic macular edema (DME). METHODS: VISTA and VIVID randomized 872 DME patients to receive intravitreal aflibercept injection (IAI) 2 mg every 4 weeks (2q4), IAI 2 mg every 8 weeks after 5 monthly doses (2q8), or macular laser photocoagulation...
July 29, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28764565/fluocinolone-acetonide-for-the-treatment-of-diabetic-macular-edema
#10
Daniele Veritti, Valentina Sarao, Laura Diplotti, Francesco Samassa, Paolo Lanzetta
Fluocinolone acetonide intravitreal implant is a non-erodible implant approved for the treatment of diabetic macular edema (DME) insufficiently responsive to available therapies. Areas covered: The injectable intravitreal implant releases fluocinolone acetonide at an average rate of 0.2 µg/day for at least 36 months. The two pooled pivotal FAME trials showed that, in patients with DME previously treated with laser photocoagulation, fluocinolone acetonide intravitreal implant was more beneficial than sham injection when looking at the proportion of patients with an improvement from baseline in visual acuity of more than 15 letters at 24 months and at 36 months...
August 9, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28761761/panretinal-photocoagulation-using-short-pulse-laser-induces-less-inflammation-and-macular-thickening-in-patients-with-diabetic-retinopathy
#11
Yoshihiro Takamura, Shogo Arimura, Seiji Miyake, Takehiro Matsumura, Makoto Gozawa, Kentaro Iwasaki, Masaru Inatani
We compared the effect of panretinal photocoagulation (PRP) using short-pulse laser (SPL) and conventional laser, regardless of the number of spots, in terms of their effect on the progression of diabetic macular edema (DME) and anterior flare intensity (AFI) in patients with high-risk nonproliferative diabetic retinopathy (non-PDR). Forty-two eyes of 42 patients were subjected to PRP using the conventional argon laser (Conv group) or SPL (SPL group). CRT and AFI levels in the SPL group were significantly lower than those in the Conv group (CRT at 4, 6, and 10 weeks; AFI at 6, 10, and 18 weeks)...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28760122/comparison-of-two-medial-epicondylectomy-techniques-in-cubital-tunnel-syndrome
#12
Meriç Çırpar, Cem Seyfi Özüak, Birhan Oktaş, İbrahim Deniz Canbeyli
OBJECTIVES: This study aims to compare partial medial epicondylectomy (PMe) and distal medial epicondylectomy (DMe) techniques in terms of sensory and motor improvements, functional results and complications. PATIENTS AND METHODS: The study included a total of 59 cubital tunnel syndrome patients (37 males, 22 females; mean age 42.3 years; range 23 to 80 years). Of the patients, DMe was applied on 30 and PMe was applied on 29. Patients were evaluated with Wilson Krout scores, Semmes-Weinstein Monofilament (SWM) test, and grip and pinch strength measurements preoperatively and at postoperative third, sixth, and 12th months...
August 2017: Eklem Hastalıkları Ve Cerrahisi, Joint Diseases & related Surgery
https://www.readbyqxmd.com/read/28758110/comparisons-of-efficacy-of-intravitreal-aflibercept-and-ranibizumab-in-eyes-with-diabetic-macular-edema
#13
Norihiro Shimizu, Toshiyuki Oshitari, Tomoaki Tatsumi, Yoko Takatsuna, Miyuki Arai, Eiju Sato, Takayuki Baba, Shuichi Yamamoto
We compared the efficacy of intravitreal aflibercept (IVA) to intravitreal ranibizumab (IVR) injections in eyes with diabetic macular edema (DME). The medical records of 49 eyes of 36 patients who were diagnosed with DME and had received IVR and 46 eyes of 40 patients who had received IVA treatment were reviewed. The central macular thickness (CMT) and best-corrected visual acuity (BCVA) were measured at the baseline and at 1, 3, and 6 months after the IVR or IVA. The mean number of injections of IVR was 2...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28756595/structural-and-functional-assessment-after-intravitreal-injection-of-ranibizumab-in-diabetic-macular-edema
#14
YuDong Fu, Ping Wang, XuXia Meng, Zhaodong Du, DaBo Wang
PURPOSE: To evaluate structure and function improvement in central retina by optical coherence tomography (OCT) and multifocal electroretinography (mf-ERG) in diabetic macular edema (DME) patients after intravitreal injection of ranibizumab (IVR) treatment. METHODS: Twenty-seven eyes in 27 patients with DME received three consecutive monthly injections of IVR (0.05 ml, 10 mg/ml) and as needed thereafter. The clinical parameters of best-corrected visual acuity (BCVA), central foveal thickness (CFT) and mf-ERG were monitored for 6 months before and after IVR...
July 29, 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28755931/blood-plasma-traits-associated-with-genetic-merit-for-feed-utilization-in-holstein-cows
#15
C D Dechow, C R Baumrucker, R M Bruckmaier, J W Blum
The objective of this study was to evaluate the potential of selection for feed utilization on associated blood plasma metabolite and hormone traits. Dry matter intake (DMI) was recorded in 970 Holsteins from 11 commercial farms in Pennsylvania and used to derive dry matter efficiency (DME; fat-corrected milk yield/DMI), crude protein efficiency (CPE; protein yield/crude protein intake), and residual feed intake (RFI, defined as actual feed intake minus expected feed intake for maintenance and milk production, based on calculation of DMI adjusted for yield, body weight, and body condition score)...
July 26, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28755024/concentration-of-acute-phase-factors-in-vitreous-fluid-in-diabetic-macular-edema
#16
Kazuhiro Kimura, Tomoko Orita, Yuka Kobayashi, Shigeo Matsuyama, Kazushi Fujimoto, Kazuhiko Yamauchi
PURPOSE: Diabetic retinal maculopathy is associated with acute and chronic local inflammation. We measured the concentrations of acute phase factors in vitreous fluid of patients with diabetic macular edema (DME) and examined their relations to visual acuity and central retinal thickness (CRT) both before and after vitrectomy. STUDY DESIGN: Retrospective. METHODS: Vitreous fluid was collected during vitreoretinal surgery from 19 patients with DME and 12 control subjects with epiretinal membrane...
July 28, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28753019/nickel-catalyzed-regio-diastereo-and-enantioselective-cross-coupling-of-3-4-epoxyalcohol-with-aryl-iodides
#17
Amit Banerjee, Hisashi Yamamoto
The first catalytic, regioselective cross-coupling of 3,4-epoxyalcohol with aryl iodides is reported. The combination of NiCl2·DME and a newly developed C2-symmetric oxazoline ligand plays a key role in selective ring opening of several 3,4-epoxy alcohols at the C4 position. This general protocol furnishes a new type of enantioenriched 4,4-diaryl alkane which also incorporates an additional 1,3-diol that can be easily transformed to a variety of functional groups. The products are formed with excellent regioselectivity (>99:1), diastereoselectivity (up to 99:1), and enantiopurity (up to >99...
July 28, 2017: Organic Letters
https://www.readbyqxmd.com/read/28731494/subthreshold-micropulse-laser-reduces-anti-vegf-injection-burden-in-patients-with-diabetic-macular-edema
#18
Elad Moisseiev, Sam Abbassi, Sumeer Thinda, Joseph Yoon, Glenn Yiu, Lawrence S Morse
PURPOSE: To evaluate the efficacy of micropulse laser in the early treatment of diabetic macular edema (DME) and its associated burden of anti-vascular endothelial growth factor (VEGF) injections. METHODS: This retrospective comparative study compared a group of 19 eyes with DME treated with micropulse laser to a matched control group of 19 eyes with DME treated with ranibizumab injections without micropulse laser. Recorded parameters included previous medical and ocular history, previous and subsequent ranibizumab injections administered for DME, visual acuity (VA), central macular thickness throughout the follow-up period, and the occurrence of any complications...
July 20, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28730118/efficiency-and-safety-of-laser-photocoagulation-with-or-without-intravitreal-ranibizumab-for-treatment-of-diabetic-macular-edema-a-systematic-review-and-meta-analysis
#19
Tian-Wei Qian, Meng-Ya Zhao, Xin-Xin Li, Xun Xu
AIM: To compare the therapeutic effect and safety of laser photocoagulation along with intravitreal ranibizumab (IVR) versus laser therapy in treatment of diabetic macular edema (DME). METHODS: Pertinent publications were identified through comprehensive searches of PubMed, EMBASE, Web of Science, Cochrane Library, and ClinicalTrials.gov to identify randomized clinical trials (RCTs) comparing IVR+laser to laser monotherapy in patients with DME. Therapeutic effect estimates were determined by weighted mean differences (WMD) of change from baseline in best corrected visual acuity (BCVA) and central retinal thickness (CRT) at 6, 12, or 24mo after initial treatment, and the risk ratios (RR) for the proportions of patients with at least 10 letters of improvement or reduction at 12mo...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28730115/diabetic-macular-edema-in-proliferative-stage-treated-with-anti-vascular-endothelial-growth-factor-agent-and-triamcinolone-acetonide-by-laser-based-strategies
#20
Gang Qiao, Wan-Jiang Dong, Yan Dai, Zhen-Hua Jiang, Hai-Ke Guo
AIM: To appraise the effect of treatment for diabetic macular edema (DME) in proliferative stage with sufficient panrentinal photocoagulation (PRP) therapy and intravitreal injections (IV) Conbercept and posterior subtenon's triamcinolone acetonide (STTA) sequential therapy. METHODS: This prospective clinical randomized controlled trial of cross-over design was conducted in three phases. The participants included cases of DME in proliferative stage. They were divided into two groups and treated with PRP before enrollment...
2017: International Journal of Ophthalmology
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