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Ryo Kawasaki, Tsuneo Konta, Kohji Nishida
AIMS: Fenofibrate and statins reduced the risk of diabetic retinopathy (DR) related treatment in clinical trials. We aimed to determine whether lipid-lowering medication use reduce the risk of DR and its treatments in patients with type 2 diabetes using a real-world health claims database. METHODS: This was an observational analysis using a nation-wide health claims database of the Japan Medical Data Center (JMDC). Type 2 diabetes was defined by the ICD-10 codes with glucose-lowering medication use...
May 22, 2018: Diabetes, Obesity & Metabolism
Neng Xiao, Gerald Gourdin, Yiying Wu
In the superoxide batteries based on O2/O2- redox chemistry, identifying an electrolyte to stabilize both alkali metal and superoxide remains challenging due to their reactivity towards electrolyte components. Bis(fluorosulfonyl)imide (FSI-) has been recognized as a "magical anion" for passivating alkali metals. Herein, we illustrate the chemical reactions between FSI- and superoxide, and the resultant dilemma when considering an anode-compatible electrolyte vs. a cathode-compatible one in K-O2 batteries...
May 22, 2018: Angewandte Chemie
Edoardo Midena, Mark Gillies, Todd A Katz, Carola Metzig, Chengxing Lu, Yuichiro Ogura
Purpose: To report the impact of baseline central retinal thickness (CRT) on outcomes in patients with diabetic macular edema (DME) in VIVID-DME and VISTA-DME. Methods: Post hoc analyses of two randomized controlled trials in which 862 DME patients were randomized 1 : 1 : 1 to treatment with intravitreal aflibercept 2.0 mg every 4 weeks (2q4), intravitreal aflibercept 2.0 mg every 8 weeks after five initial monthly doses (2q8), or macular laser photocoagulation at baseline and as needed...
2018: Journal of Ophthalmology
Ye He, Xin-Jun Ren, Bo-Jie Hu, Wai-Ching Lam, Xiao-Rong Li
BACKGROUND: This meta-analysis evaluated the effectiveness and safety of dexamethasone (DEX) implant and intravitreal anti-vascular endothelial growth factor (VEGF) treatment for diabetic macular edema (DME). METHODS: The PubMed, Embase, website and Cochrane Library databases were comprehensively searched for studies comparing DEX implant with anti-VEGF in patients with DME. Best-corrected visual acuity (BCVA), central subfield thickness (CST) and adverse events were extracted from the final eligible studies...
May 21, 2018: BMC Ophthalmology
Lei Yan, Muhammad Riaz, Xiuwen Wu, Chenqing Du, Yalin Liu, Cuncang Jiang
Aluminum (Al) phytotoxicity is a major limitation in the production of crops in the soils with pH ≤ 5. Boron (B) is indispensable nutrient for the development of higher plants and B role has been reported in the alleviation Al toxicity. Trifoliate orange rootstock was grown in two B and two Al concentrations. The results of the present study showed that Al toxicity adversely inhibited root elongation and exhibited higher oxidative stress in terms of H2 O2 and O2 - under B-deficiency. Additionally, the X-ray diffraction (XRD) analysis confirmed the increase of the cellulose crystallinity in the cell wall (CW)...
May 17, 2018: Environmental Pollution
Tien Y Wong, Jennifer Sun, Ryo Kawasaki, Paisan Ruamviboonsuk, Neeru Gupta, Van Charles Lansingh, Mauricio Maia, Wanjiku Mathenge, Sunil Moreker, Maji M K Muqit, Serge Resnikoff, Juan Verdaguer, Peiquan Zhao, Frederick Ferris, Lloyd P Aiello, Hugh R Taylor
Diabetes mellitus (DM) is a global epidemic and affects populations in both developing and developed countries, with differing health care and resource levels. Diabetic retinopathy (DR) is a major complication of DM and a leading cause of vision loss in working middle-aged adults. Vision loss from DR can be prevented with broad-level public health strategies, but these need to be tailored to a country's and population's resource setting. Designing DR screening programs, with appropriate and timely referral to facilities with trained eye care professionals, and using cost-effective treatment for vision-threatening levels of DR can prevent vision loss...
May 15, 2018: Ophthalmology
A Zh Fursova, N V Chubar, M S Tarasov, I F Niculich, M A Vasilyeva, O G Gusarevich
PURPOSE: To evaluate clinical effectiveness of aflibercept therapy for patients with diabetic macular edema (DME) - both naïve to the drug and unresponsive to previous anti-VEGF treatment. MATERIAL AND METHODS: The study included 127 patients (127 eyes) divided into two groups. The first group consisted of 100 primary DME patients (100 eyes) with mean age of 68.48±2.56 years and average disease duration of 12.50±7.85 years. The second group comprised 27 patients (27 eyes) with resistant macular edema who had received three or more 0...
2018: Vestnik Oftalmologii
Yuki Yoshizumi, Zaigen Ohara, Hitoshi Tabuchi, Hitomi Sumino, Yukiko Maeda, Hideki Mochizuki, Ken Yamane, Yoshiaki Kiuchi
PURPOSE: To evaluate the effectiveness of the combination of vitrectomy with kallidinogenase for diabetic macular edema (DME). METHODS: This study was designed as a prospective, randomized, multicenter study comparing 19 eyes of 19 patients who received 150 units of kallidinogenase administered a day for 52 weeks from the day after vitrectomy (study group) with 20 eyes of 20 patients who received no kallidinogenase (control group). The main outcome measurements included logMAR visual acuity and central foveal thickness (CFT) before surgery and at 3, 6, 9, and 12 months after vitrectomy...
May 12, 2018: International Ophthalmology
Rahul K Reddy, Dante J Pieramici, Shamika Gune, Avanti Ghanekar, Na Lu, Carlos Quezada-Ruiz, Caroline R Baumal
PURPOSE: To determine whether there are baseline characteristics that distinguish patients with diabetic macular edema (DME) with coexisting macular nonperfusion (MNP) at baseline and assess these patients' potential to achieve favorable visual acuity (VA), anatomic, and diabetic retinopathy (DR) outcomes over 24 months. DESIGN: Post hoc analysis of RIDE/RISE, 2 phase 3, parallel, randomized, multicenter, double-masked trials ( NCT00473382; NCT00473330)...
May 8, 2018: Ophthalmology
Hannah M Nicholas, Conrad A P Goodwin, Jon G C Kragskow, Selena J Lockyer, David P Mills
Alkali metal amides are vital reagents in synthetic chemistry and the bis(silyl)amide {N(SiMe₃)₂} (N′′) is one of the most widely-utilized examples. Given that N′′ has provided landmark complexes, we have investigated synthetic routes to lithium and sodium bis(silyl)amides with increased steric bulk to analyse the effects of R-group substitution on structural features. To perform this study, the bulky bis(silyl)amines {HN(Sit BuMe₂)(SiMe₃)}, {HN(Sii Pr₃)(SiMe₃)}, {HN(Sit BuMe₂)₂}, {HN(Sii Pr₃)(Sit BuMe₂)} and {HN(Sii Pr₃)₂} ( 1 ) were prepared by literature procedures as colourless oils; on one occasion crystals of 1 were obtained...
May 10, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Agnieszka Kalinowska, Katarzyna Nowomiejska, Agnieszka Brzozowska, Ryszard Maciejewski, Robert Rejdak
Aim: To detect abnormality of the visual function in naïve patients with cystoid diabetic macular edema (DME) using M-charts, Amsler test, and white on white (W/W) and blue on yellow (B/Y) perimetry. Methods: There were 64 eyes included in the study: 30 eyes with DME, 22 eyes with diabetes without DME, and 12 eyes of normal subjects. Conventional W/W perimetry and B/Y perimetry were performed within the central 10° of the visual field. To assess metamorphopsia, Amsler test and M-charts were used...
2018: BioMed Research International
Patricia S Graham, Georgia Kaidonis, Sotoodeh Abhary, Mark C Gillies, Mark Daniell, Rohan W Essex, John H Chang, Stewart R Lake, Bishwanath Pal, Alicia J Jenkins, Alex W Hewitt, Ecosse L Lamoureux, Philip G Hykin, Nikolai Petrovsky, Matthew A Brown, Jamie E Craig, Kathryn P Burdon
BACKGROUND: Diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR) are sight-threatening complications of diabetes mellitus and leading causes of adult-onset blindness worldwide. Genetic risk factors for diabetic retinopathy (DR) have been described previously, but have been difficult to replicate between studies, which have often used composite phenotypes and been conducted in different populations. This study aims to identify genetic risk factors for DME and PDR as separate complications in Australians of European descent with type 2 diabetes...
May 8, 2018: BMC Medical Genetics
Elina Glaubke, Holger Bastians
The regulation of mitotic spindle orientation is essential to ensure proper cell division and development (Kiyomitsua and Cheeseman Nat Cell Biol 14:311-317, 2012). For identification of potential spindle orientation regulators, determination of the mitotic spindle angle is a well-known but time-consuming procedure. Here we describe a simple and time-saving phenotypic screening assay for the identification of potential spindle orientation regulators. This screen is based on the analysis of monopolar mitotic spindle structures, which form upon inhibition of the mitotic kinesin Eg5/KSP by the small-molecule inhibitor dimethylenastron (DME) or similar compounds...
2018: Methods in Molecular Biology
Scott A Pattenaude, Nickolas H Anderson, Suzanne C Bart, Andrew J Gaunt, Brian L Scott
Solvent exchange of NpCl4(DME)2 with THF proceeds simply to yield NpCl4(THF)3, whereas PuCl4(DME)2 is unstable in THF, partially decomposing to the mixed valent [PuIIICl2(THF)5][PuIVCl5(THF)] salt. Reduction of NpCl4(THF)3 with CsC8 ultimately afforded NpCl3(py)4, the only example of a structurally characterized solvated Np(iii) halide. The method demonstrates a route to a well-defined Np(iii) starting material without the need to employ scarcely available Np metal.
May 8, 2018: Chemical Communications: Chem Comm
Catharina Busch, Dinah Zur, Samantha Fraser-Bell, Inês Laíns, Ana Rita Santos, Marco Lupidi, Carlo Cagini, Pierre-Henry Gabrielle, Aude Couturier, Valérie Mané-Tauty, Ermete Giancipoli, Giuseppe D'Amico Ricci, Zafer Cebeci, Patricio J Rodríguez-Valdés, Voraporn Chaikitmongkol, Atchara Amphornphruet, Isaac Hindi, Kushal Agrawal, Jay Chhablani, Anat Loewenstein, Matias Iglicki, Matus Rehak
AIMS: To compare functional and anatomical outcomes of continued anti-vascular endothelial growth factor (VEGF) therapy versus dexamethasone (DEX) implant in eyes with refractory diabetic macular edema (DME) after three initial anti-VEGF injections in a real-world setting. METHODS: To be included in this retrospective multicenter, case-control study, eyes were required: (1) to present with early refractory DME, as defined by visual acuity (VA) gain ≤ 5 letters or reduction in central subfield thickness (CST) ≤ 20%, after a loading phase of anti-VEGF therapy (three monthly injections) and (2) to treat further with (a) anti-VEGF therapy or (b) DEX implant...
May 5, 2018: Acta Diabetologica
Vineeta Soni, Dipesh M Sharma, Benudhar Punji
Regioselective C(2)-H difluoroalkylation of C-3 unsubstituted indoles with commonly available fluoroalkyl bromides is successfully achieved employing a simple nickel catalyst system, (DME)NiCl2/Xantphos. This methodology shows excellent regioselectivity and exhibits broad substrate scope. Various functional groups, such as -OMe, -F, -Br are tolerated on the indole backbone to give the difluoroalkylated products in moderate to good yields. Preliminary mechanistic findings demonstrate that the reaction is homogeneous in nature and involves a radical manifold...
May 3, 2018: Chemistry, An Asian Journal
Yoshihiro Takamura, Takehiro Matsumura, Shogo Arimura, Makoto Gozawa, Masakazu Morioka, YutakaYamada, Masaru Inatani
Purpose: To introduce a novel laser photocoagulation (PC) protocol named merged image-guided PC (MIG-PC), which included merging the images of the fundus, optical coherence tomography (OCT) map, and fluorescein angiography (FA). We compared the anatomical and functional results between MIG-PC and FA-guided PC (FG-PC) for the treatment of focal diabetic macular edema (DME). Method: We examined the treatment outcomes in 27 consecutive eyes treated with MIG-PC compared with 28 matched eyes treated with FG-PC...
2018: International Journal of Endocrinology
Jennifer M Frost, M Yvonne Kim, Guen Tae Park, Ping-Hung Hsieh, Miyuki Nakamura, Samuel J H Lin, Hyunjin Yoo, Jaemyung Choi, Yoko Ikeda, Tetsu Kinoshita, Yeonhee Choi, Daniel Zilberman, Robert L Fischer
The DEMETER (DME) DNA glycosylase catalyzes genome-wide DNA demethylation and is required for endosperm genomic imprinting and embryo viability. Targets of DME-mediated DNA demethylation reside in small, euchromatic, AT-rich transposons and at the boundaries of large transposons, but how DME interacts with these diverse chromatin states is unknown. The STRUCTURE SPECIFIC RECOGNITION PROTEIN 1 (SSRP1) subunit of the chromatin remodeler FACT (facilitates chromatin transactions), was previously shown to be involved in the DME-dependent regulation of genomic imprinting in Arabidopsis endosperm...
April 30, 2018: Proceedings of the National Academy of Sciences of the United States of America
Matias Iglicki, Catharina Busch, Dinah Zur, Mali Okada, Miriana Mariussi, Jay Kumar Chhablani, Zafer Cebeci, Samantha Fraser-Bell, Voraporn Chaikitmongkol, Aude Couturier, Ermete Giancipoli, Marco Lupidi, Patricio J Rodríguez-Valdés, Matus Rehak, Adrian Tien-Chin Fung, Michaella Goldstein, Anat Loewenstein
PURPOSE: To investigate efficacy and safety of repeated dexamethasone (DEX) implants over 24 months, in diabetic macular edema (DME) eyes that were treatment naive compared with eyes refractory to anti-vascular endothelial growth factor treatment, in a real-life environment. METHODS: This multicenter international retrospective study assessed best-corrected visual acuity and central subfield thickness (CST) of naive and refractory eyes to anti-vascular endothelial growth factor injections treated with dexamethasone implants...
April 24, 2018: Retina
Jana Stefanickova, Jose Cunha-Vaz, Michael Ulbig, Ian Pearce, Alvaro Fernández-Vega Sanz, Panagiotis Theodossiadis, Laurent Kodjikian, Alexander Izmailov, Dominic Muston, Zdravko Vassilev, Benedicte Lamotte, Claudia Tückmantel, Sabine Friedl, Andreas Altemark, Hans-Jörg Schwarz, Todd Katz
PURPOSE: Antivascular endothelial growth factor agents are increasingly used in diabetic macular oedema (DME); however, there are few studies exploring their use in DME in real-world settings. METHODS: POLARIS was a noninterventional, multicentre study to monitor 12-month outcomes in patients starting ranibizumab treatment in routine practices. The primary outcome was mean change in visual acuity (VA) from baseline to month 12 (last observation carried forward approach)...
April 25, 2018: Acta Ophthalmologica
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