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https://www.readbyqxmd.com/read/27911427/-modern-approach-to-early-diagnosis-and-pathogenetic-treatment-of-diabetic-retinopathy
#1
I V Vorob'eva
AIM: To improve the approach to pathogenetic treatment of diabetic retinopathy (DR) through early diagnosis and a new method for predicting disease progression. MATERIAL AND METHODS: The study enrolled 330 type 2 diabetes patients with DR (660 eyes), of whom women constituted 64.6%, men - 35.4%. The mean patient age was 62.3±2.3 years. Three groups were formed: the controls - 30 healthy volunteers (60 eyes) and 30 type 2 diabetes patients without ocular involvement (DR 0, 60 eyes); group 1 - 30 type 2 diabetes patients with DR I but no diabetic macular edema (DR I without DME, 60 eyes) that were treated with calcium dobesilate; group 2 - 240 type 2 diabetes patients, who had diabetic retinopathy of different stages (DR I, II, or III with DME, 480 eyes) and received laser retinal photocoagulation (LRP)...
2016: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/27898414/outcomes-after-a-1-year-treatment-with-ranibizumab-for-diabetic-macular-edema-in-a-clinical-setting
#2
Linda Hrarat, Franck Fajnkuchen, Marouane Boubaya, Vincent Lévy, Valérie Sarda, Typhaine Grenet, Sylvia Nghiem-Buffet, Gilles Chaine, Audrey Giocanti-Auregan
PURPOSE: The aim of this study was to assess the efficacy and safety of ranibizumab in patients with diabetic macular edema (DME). METHODS: We conducted a retrospective analysis of consecutive patients with vision loss due to DME who were treated with ranibizumab. All patients received a loading dose of 3 monthly injections followed by re-treatments on an as-needed basis. The primary endpoint was the change in best-corrected visual acuity (BCVA) at 12 months. Secondary endpoints were the change in central retinal thickness (CRT) and the number of intravitreal injections (IVI) at 12 months...
November 30, 2016: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/27898184/intrinsic-kinetics-for-dimethyl-ether-synthesis-from-plasma-activation-co2-hydrogenation-over-cu-fe-ce-hzsm-5
#3
Tongming Su, Xinhui Zhou, Zuzeng Qin, Hongbing Ji
The CO2 was activated in a plasma reactor followed by hydrogenation over the Cu-Fe-Ce/HZSM-5 catalyst, and the intrinsic kinetics of the plasma-catalytic process were studied. Compared with the CO2 hydrogenation using the Cu-Fe-Ce/HZSM-5 alone, the CO2 conversion and the dimethyl ether (DME) selectivity for the plasma-catalytic process were increased by 16.3%, and 10.1%, respectively, indicating the CO2 was activated by the plasma and promoted the CO2 hydrogenation. The intrinsic kinetics study shown that the activation energies of the methanol synthesis, the reverse water-gas shift reaction, and the methanol dehydration to DME were 149...
November 29, 2016: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/27867947/association-of-insulin-treatment-versus-oral-hypoglycaemic-agents-with-diabetic-retinopathy-and-its-severity-in-type-2-diabetes-patients-in-cameroon-sub-saharan-africa
#4
Ahmadou M Jingi, Jean Jacques N Noubiap, Mickael Essouma, Jean Joel R Bigna, Jobert Richie N Nansseu, Augustin Ellong, Côme Ebana Mvogo
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease associated with multiple macro and microvascular complications, diabetic retinopathy (DR) being the commonest one. Recent literature has reported an increased risk of DR with insulin use. METHODS: We carried out a cross-sectional study at the Ophthalmology Department of the Douala General Hospital (DGH) during a 2-year period to explore the association between insulin treatment and both DR and its severity as compared with oral hypoglycemic agents (OHAs) in Cameroonian T2DM patients aged ≥35 years, and who were all screened for DR through eye examination including exhaustive retinal evaluation...
October 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27865012/half-sandwich-alkyl-amido-and-iodo-sm-ii-complexes-coordinated-by-1-3-6-8-tetra-tert-butylcarbazol-9-yl-ligand-non-%C3%B0-onventional-sterically-governed-oxidation-of-tbu4carb-2sm
#5
Alexander Trifonov, Alexander Selikhov, Tatyana Mahrova, Anton Cherkasov, Georgy Fukin, Laurent Maron
The half-sandwich tetra-tert-butylcarbazol-9-yl iodo complex [tBu4CarbSm(μ-I)(THF)2]2 (1) was synthesized by the salt-metathesis reaction of tBu4CarbK and SmI2(THF)2 in THF. Complex 1 along with metallic Cu was also isolated from the oxidation reaction of (tBu4Carb)2Sm by CuI. The formation of stable radical tBu4Carb* was detected in this non-conventional process indicating preferential oxidation of anion tBu4Carb- vs Sm(II). The treatment of 1 with two equivalents of dibenzo-18-crown-6 resulted in heterolytic dissociation of a η5-bond Sm(II)-tBu4Carb and afforded an ionic compound [tBu4carb-][SmI(crown)(THF)2]+ (4)...
November 16, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27860417/an-electrolyte-for-reversible-cycling-of-na-metal-and-na-intercalation-compounds
#6
Lukas Schafzahl, Ilie Hanzu, Martin Wilkening, Stefan A Freunberger
Na battery chemistries show poor passivation behavior of low voltage Na storage compounds and Na metal with organic carbonate based electrolytes adopted from Li-ion batteries. A suitable electrolyte remains therefore a major challenge for establishing Na batteries. Here we report highly concentrated sodium bis(fluorosulfonyl)imide (NaFSI) in dimethoxyethane (DME) electrolytes that forms a stable solid electrolyte interface on anode materials. This permitted non-dendritic Na metal cycling with ~98 % coulombic efficiency as shown for up to 300 cycles...
November 18, 2016: ChemSusChem
https://www.readbyqxmd.com/read/27853919/care-coordination-for-community-transitions-for-individuals-post-stroke-returning-to-low-resource-rural-communities
#7
Patrick Kitzman, Keisha Hudson, Violet Sylvia, Frances Feltner, Johnnie Lovins
High rates of hospital readmissions have been shown within 12 months post-discharge from inpatient rehabilitation following stroke. Multiple studies coupled with our previous work indicate a need for care support for stroke survivors' transitions to the community. The Kentucky Care Coordination for Community Transitions (KC(3)T) program was developed to provide access to medical, social, and environmental services to support community transitions for individuals with neurological conditions and their caregivers living in Kentucky...
November 16, 2016: Journal of Community Health
https://www.readbyqxmd.com/read/27853011/long-term-effect-of-anti-vascular-endothelial-growth-factor-injections-on-intraocular-pressure
#8
Ashiyana Nariani, Blake Williams, Seenu M Hariprasad
OBJECTIVE: There is a substantial debate in the ophthalmology community about whether anti-vascular endothelial growth factor (VEGF) injections result in a long-term increase in intraocular pressure (IOP). DESIGN: We performed a retrospective study to investigate how the number and timing of intravitreal injections in patients with age-related macular degeneration (AMD) and diabetic macular edema (DME) affect IOP over time. METHODS: We collected long-term IOP data on patients receiving anti-VEGF injections at our institution...
September 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27847634/initiation-of-intravitreal-aflibercept-injection-treatment-in-patients-with-diabetic-macular-edema-a-review-of-vivid-dme-and-vista-dme-data
#9
Focke Ziemssen, Patricio G Schlottman, Jennifer I Lim, Hansjürgen Agostini, Gabriele E Lang, Francesco Bandello
BACKGROUND: Diabetic macular edema (DME) shows a gradual and sustained functional and morphologic response to anti-vascular endothelial growth factor (VEGF) drugs, but the optimal schedule for initiation of anti-VEGF therapy is not known. This study evaluates the treatment response behavior of DME in the Phase 3 trials of intravitreal aflibercept, with 5 initial intravitreal aflibercept injections (IAI), 2 mg every 4 weeks (2q4), in the upload phase. METHODS: This post hoc pooled analysis of the VISTA-DME (NCT01363440) and VIVID-DME (NCT01331681) trials evaluated the change in best-corrected visual acuity (BCVA) and central retinal thickness (CRT) during the upload phase, using pooled data from both IAI treatment groups [2q4 and 2 mg every 8 weeks (2q8)]...
2016: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/27847621/fusion-proteins-for-treatment-of-retinal-diseases-aflibercept-ziv-aflibercept-and-conbercept
#10
REVIEW
João Rafael de Oliveira Dias, Gabriel Costa de Andrade, Eduardo Amorim Novais, Michel Eid Farah, Eduardo Büchele Rodrigues
In the last few years, monoclonal antibodies have revolutionized the treatment of retinal neovascular diseases. More recently, a different class of drugs, fusion proteins, has provided an alternative treatment strategy with pharmacological differences. In addition to commercially available aflibercept, two other drugs, ziv-aflibercept and conbercept, have been studied in antiangiogenic treatment of ocular diseases. In this scenario, a critical review of the currently available data regarding fusion proteins in ophthalmic diseases may be a timely and important contribution...
2016: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/27836430/randomized-trial-of-treat-and-extend-ranibizumab-with-and-without-navigated-laser-for-diabetic-macular-edema-trex-dme-1-year-outcomes
#11
John F Payne, Charles C Wykoff, W Lloyd Clark, Beau B Bruce, David S Boyer, David M Brown
PURPOSE: To compare monthly dosing with a treat and extend algorithm using ranibizumab 0.3 mg with and without angiography-guided macular laser photocoagulation for center-involving diabetic macular edema (DME). DESIGN: Multicenter, prospective, randomized clinical trial. PARTICIPANTS: A total of 150 eyes from 116 subjects were randomized into 3 cohorts: Monthly (n = 30), TReat and EXtend without macular laser photocoagulation (TREX; n = 60), and treat and extend with angiography-GuIded macular LAser photocoagulation (GILA; n = 60)...
November 8, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27830205/comparison-of-subthreshold-diode-laser-micropulse-therapy-versus-conventional-photocoagulation-laser-therapy-as-primary-treatment-of-diabetic-macular-edema
#12
Farhad Fazel, Majid Bagheri, Khodayar Golabchi, Hamidreza Jahanbani Ardakani
PURPOSE: The aim of the present study was to investigate the effect of subthreshold diode laser micropulse (SDM) in comparison with conventional laser photocoagulation in the treatment of the diabetic macular edema (DME). METHODS: Sixty-eight eyes from 68 patients with clinically significant DME were divided randomly into two equal groups. In the first group, SDM photocoagulation was employed, while conventional laser photocoagulation was performed on the eyes of the second group...
December 2016: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/27830204/outcomes-of-vitrectomy-membranectomy-and-internal-limiting-membrane-peeling-in-patients-with-refractory-diabetic-macular-edema-and-non-tractional-epiretinal-membrane
#13
Fariba Ghassemi, Fatemeh Bazvand, Ramak Roohipoor, Mehdi Yaseri, Narges Hassanpoor, Mohammad Zarei
PURPOSE: To evaluate the efficacy of vitrectomy, membranectomy, and internal limiting membrane (ILM) peeling on macular thickness and best corrected visual acuity (BCVA) in patients with refractory diffuse diabetic macular edema (DME) and non-tractional epiretinal membrane (NT-ERM). METHODS: This prospective interventional case series included eyes with refractory DME (central subfield macular thickness [CSMT] > 300 μm) after at least two intravitreal injections of bevacizumab (IVB) and one intravitreal injection of triamcinolone (IVT), and accompanying NT-ERM...
December 2016: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/27821435/what-can-be-learned-from-recent-new-drug-applications-a-systematic-review-of-drug-interaction-data-for-drugs-approved-by-the-u-s-fda-in-2015
#14
Jingjing Yu, Zhu Zhou, Katie H Owens, Tasha K Ritchie, Isabelle Ragueneau-Majlessi
As a follow-up to previous reviews, the aim of the present analysis was to systematically examine all drug metabolism, transport, PK, and DDI data available in the 33 NDAs and 12 BLAs approved by the FDA in 2015, using the University of Washington Drug Interaction Database©, and to highlight the significant findings. All of the NDAs were well-characterized with regard to drug metabolism, transport, and/or organ impairment, and were fully analyzed in this review. In vitro, a majority of the NMEs were found to be substrates or inhibitors/inducers of at least one DME or transporter...
November 7, 2016: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/27815675/-what-can-anti-vegf-therapy-achieve-in-clinical-routine-effectiveness-of-anti-vegf-therapy-in-patients-with-macular-diseases-in-clinical-routine-on-1492-eyes-in-austria
#15
K Wiesinger, P Reinelt, A Ennemoser, M Edelmayr, U Schönherr
BACKGROUND: The aim of this user observational study was to illustrate the effectiveness of intravitreal operative medication administration (IVOM) in the clinical routine. DESIGN: A monocentric, single arm, prospective study. MATERIAL AND METHODS: Included in this study were all patients in whom a macular edema was diagnosed during an ophthalmological examination at the Barmherzigen Brüdern Hospital in Linz from November 2012 to August 2014 and who were treated as outpatients or day clinic patients with IVOM using anti-vascular endothelial growth factor (VEGF)...
November 4, 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/27805016/derepressing-muscleblind-expression-by-mirna-sponges-ameliorates-myotonic-dystrophy-like-phenotypes-in-drosophila
#16
Estefania Cerro-Herreros, Juan M Fernandez-Costa, María Sabater-Arcis, Beatriz Llamusi, Ruben Artero
Myotonic Dystrophy type 1 (DM1) originates from alleles of the DMPK gene with hundreds of extra CTG repeats in the 3' untranslated region (3' UTR). CUG repeat RNAs accumulate in foci that sequester Muscleblind-like (MBNL) proteins away from their functional target transcripts. Endogenous upregulation of MBNL proteins is, thus, a potential therapeutic approach to DM1. Here we identify two miRNAs, dme-miR-277 and dme-miR-304, that differentially regulate muscleblind RNA isoforms in miRNA sensor constructs. We also show that their sequestration by sponge constructs derepresses endogenous muscleblind not only in a wild type background but also in a DM1 Drosophila model expressing non-coding CUG trinucleotide repeats throughout the musculature...
November 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27803859/an-eighteen-month-follow-up-study-on-the-effects-of-intravitreal-dexamethasone-implant-in-diabetic-macular-edema-refractory-to-anti-vegf-therapy
#17
Fernanda Pacella, Maria Rosaria Romano, Paolo Turchetti, Giovanna Tarquini, Anna Carnovale, Antonella Mollicone, Alessandra Mastromatteo, Elena Pacella
AIM: To evaluate the long-term efficacy and safety of dexamethasone implants in subjects affected by diabetic macular edema (DME) resistant to anti-vascular endothelial growth factor (VEGF) therapy. METHODS: Thirty-two DME patients were enrolled. A 700 microgram slow release Intravitreal Dexamethasone Implant (Ozurdex(®)) was placed in the vitreous cavity. All patients were followed for 18mo. Best-corrected visual acuity (BCVA) measured with Early Treatment Diabetic Retinopathy Study (ETDRS) and central macular thickness (CMT) exams were carried out at baseline (T0) and after 1 (T1), 3 (T3), 4 (T4), 6 (T6), 9 (T9), 12 (T12), 15 (T15), and 18mo (T18) post injection...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27802662/non-monotonic-dynamics-of-water-in-its-binary-mixture-with-1-2-dimethoxy-ethane-a-combined-thz-spectroscopic-and-md-simulation-study
#18
Debasish Das Mahanta, Animesh Patra, Nirnay Samanta, Trung Quan Luong, Biswaroop Mukherjee, Rajib Kumar Mitra
A combined experimental (mid- and far-infrared FTIR spectroscopy and THz time domain spectroscopy (TTDS) (0.3-1.6 THz)) and molecular dynamics (MD) simulation technique are used to understand the evolution of the structure and dynamics of water in its binary mixture with 1,2-dimethoxy ethane (DME) over the entire concentration range. The cooperative hydrogen bond dynamics of water obtained from Debye relaxation of TTDS data reveals a non-monotonous behaviour in which the collective dynamics is much faster in the low Xw region (where Xw is the mole fraction of water in the mixture), whereas in Xw ∼ 0...
October 28, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27799737/intravitreal-bevacizumab-injections-for-diabetic-macular-edema-predictors-of-response-a-retrospective-study
#19
Lavnish Joshi, Asaf Bar, Oren Tomkins-Netzer, Satish Yaganti, Jiten Morarji, Panayiotis Vouzounis, Sophie Seguin-Greenstein, Simon R Taylor, Sue Lightman
BACKGROUND: Outcomes of intravitreal antivascular endothelial growth factor injections are variable among patients with diabetic macular edema (DME). The aim of this study was to determine the ocular and systemic predictors of DME response to intravitreal bevacizumab (IVB). METHODS: Retrospective review over 2 years of 78 eyes from 54 patients. An anatomical response to IVB was defined as a 20% reduction in central macula thickness after the first course (three injections) of IVB...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27797357/reprogramming-of-dna-methylation-is-critical-for-nodule-development-in-medicago-truncatula
#20
Carine Satgé, Sandra Moreau, Erika Sallet, Gaëlle Lefort, Marie-Christine Auriac, Céline Remblière, Ludovic Cottret, Karine Gallardo, Céline Noirot, Marie-Françoise Jardinaud, Pascal Gamas
The legume-Rhizobium symbiosis leads to the formation of a new organ, the root nodule, involving coordinated and massive induction of specific genes. Several genes controlling DNA methylation are spatially regulated within the Medicago truncatula nodule, notably the demethylase gene, DEMETER (DME), which is mostly expressed in the differentiation zone. Here, we show that MtDME is essential for nodule development and regulates the expression of 1,425 genes, some of which are critical for plant and bacterial cell differentiation...
October 31, 2016: Nature Plants
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