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https://www.readbyqxmd.com/read/28549848/relationship-between-visual-acuity-and-retinal-thickness-during-anti-vascular-endothelial-growth-factor-therapy-for-retinal-diseases
#1
William C Ou, David M Brown, John F Payne, Charles C Wykoff
PURPOSE: Investigate the relationship between best-corrected visual acuity (BCVA) and central retinal thickness (CRT) in eyes receiving ranibizumab for three common retinal diseases. DESIGN: Retrospective analysis of clinical trial data METHODS: Early Treatment Diabetic Retinopathy Study BCVA and spectral-domain optical coherence tomography measured CRT of 387 eyes of 345 patients enrolled in six prospective clinical trials for management of neovascular age-related macular degeneration (AMD), diabetic macular edema (DME), and retinal vein occlusion (RVO) were evaluated by Pearson correlation and linear regression...
May 23, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28546935/prognostic-factors-of-short-term-outcomes-of-intravitreal-ranibizumab-in-diabetic-macular-edema
#2
I-An Lai, Wei-Cherng Hsu, Chung-May Yang, Yi-Ting Hsieh
AIM: To evaluate the prognostic factors for short-term visual and anatomical improvement of intravitreal ranibizumab (IVR) for diabetic macular edema (DME). METHODS: Fifty-one eyes from 35 patients that received three consecutive monthly IVR for DME with moderate visual loss were retrospectively recruited; all cases had their baseline best-corrected visual acuity (BCVA) between 20/400 and 20/40. BCVA and central subfield thickness (CST) at baseline and month 3 were collected...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28546934/foveal-thickness-reduction-after-anti-vascular-endothelial-growth-factor-treatment-in-chronic-diabetic-macular-edema
#3
Gabriel Willmann, Antonio Brunno Nepomuceno, Katharina Messias, Leticia Barroso, Ingrid U Scott, André Messias, Rodrigo Jorge
AIM: To report foveal thickness reduction in eyes with resolution of macular edema and recovery of a foveal depression after one-year of anti-vascular endothelial growth factor (anti-VEGF) therapy for center-involving diabetic macular edema (DME). METHODS: Foveal thickness was assessed with optical coherence tomography to determine the central subfield foveal thickness (CSFT) and macular volume in 42 eyes with DME (CSFT>275 µm). Evaluations also included measurement of best-corrected visual acuity (BCVA), and were performed at baseline, and upon foveal depression recovery achieved after 12 monthly intravitreal injections of either 1...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28544030/trapping-a-silicon-i-radical-with-carbenes-a-cationic-caac-silicon-i-radical-and-an-nhc-parent-silyliumylidene-cation
#4
Yan Li, Yuk-Chi Chan, Bi-Xiang Leong, Yongxin Li, Emma Richards, Indu Purushothaman, Susmita De, Pattiyil Parameswaran, Cheuk-Wai So
The trapping of a silicon(I) radical with N-heterocyclic carbenes is described. The reaction of the cyclic (alkyl)(amino) carbene [cAACMe ] (cAACMe =:C(CMe2 )2 (CH2 )NAr, Ar=2,6-iPr2 C6 H3 ) with H2 SiI2 in a 3:1 molar ratio in DME afforded a mixture of the separated ion pair [(cAACMe )2 Si:(.) ](+) I(-) (1), which features a cationic cAAC-silicon(I) radical, and [cAACMe -H](+) I(-) . In addition, the reaction of the NHC-iodosilicon(I) dimer [IAr (I)Si:]2 (IAr =:C{N(Ar)CH}2 ) with 4 equiv of IMe (:C{N(Me)CMe}2 ), which proceeded through the formation of a silicon(I) radical intermediate, afforded [(IMe )2 SiH](+) I(-) (2) comprising the first NHC-parent-silyliumylidene cation...
May 24, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28542922/study-of-retinal-neurodegeneration-and-maculopathy-in-diabetic-meriones-shawi-a-particular-animal-model-with-human-like-macula
#5
Imane Hammoum, Maha Benlarbi, Ahmed Dellaa, Klaudia Szabó, Bulcsú Dékány, Dávid Csaba, Zsuzsanna Almási, Rozina I Hajdú, Rached Azaiz, Ridha Charefeddine, Ákos Lukáts, Rafika Benchouacha-Chekir
The purpose of this work was to evaluate a potentially useful animal model, Meriones shawi (M.sh) - developing metabolic X syndrome, diabetes and possessing a visual streak similar to human macula - in the study of diabetic retinopathy and diabetic macular edema (DME). Type 2 diabetes (T2D) was induced by high fat diet administration in M.sh. Body weights, blood glucose levels were monitored throughout the study. Diabetic retinal histopathology was evaluated 3 and 7 months after diabetes induction. Retinal thickness was measured, retinal cell types were labeled by immunohistochemistry and the number of stained elements were quantified...
May 20, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28540655/a-review-of-subthreshold-micropulse-laser-for-treatment-of-macular-disorders
#6
REVIEW
Paula Scholz, Lebriz Altay, Sascha Fauser
Micropulse laser treatment is an alternative to the conventional continuous-wave laser for the treatment of retinal or macular diseases. In contrast to the conventional laser, the therapeutic effect of the subthreshold micropulse laser is not accompanied by thermal retinal damage. This fact is of particular importance when a treatment near the fovea is required. Micropulse treatment is applied in indications such as central serous chorioretinopathy (CSC), diabetic macular edema (DME), or macular edema due to retinal vein occlusion (RVO)...
May 24, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28539720/comparison-of-ultrasound-assisted-extraction-and-dynamic-maceration-over-content-of-tagitinin-c-obtained-from-tithonia-diversifolia-hemsl-a-gray-leaves-using-factorial-design
#7
Aline M R Silva, Nayara L O Ferreira, Anselmo E Oliveira, Leonardo L Borges, Edemilson C Conceição
BACKGROUND: Tithonia diversifolia belongs to the Asteraceae family. The leaves of T. diversifolia have been studied lately because of the presence of tagitinin C. OBJECTIVE: Looking for an easy and inexpensive method to extract tagitinin C from T. diversifolia leaves, this work aims to conduct a screening to evaluate the influence of different experimental factors using the dynamic maceration and ultrasound-assisted extraction methods with 2(3) factorial design based on response surface methodology in enhancing this chemical marker extraction...
April 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28523527/impact-of-estimated-glomerular-filtration-rate-on-diabetic-macular-edema
#8
Shreyas Temkar, Nishanthini Karuppaiah, Brijesh Takkar, Dipankar Bhowmik, Manjari Tripathi, Sivasubramanian Ramakrishnan, Yog Raj Sharma, Rajpal Vohra, Rohan Chawla, Pradeep Venkatesh
PURPOSE: Diabetic macular edema (DME) is a major cause of visual impairment in patients with diabetes and is influenced by various systemic factors. This study evaluates the effect of renal status on DME using estimated glomerular filtration rate (eGFR) as a study marker. METHODS: This was a prospective observational cross-sectional study. One hundred and ninety-five patients of diabetic retinopathy (DR) were included. Group 1 had patients of DR without DME (n = 100), and group 2 had patients of DR with DME (n = 95)...
May 18, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28522399/anti-allergic-and-profilaggrin-proflg-mrna-expression-modulatory-effects-of-sacran
#9
Nlandu R Ngatu, Keiichi Motoyama, Yasumitsu Nishimura, Maiko Kaneko Okajima, Ryoji Hirota, Taishi Higashi, Suni Lee, Hidetoshi Arima, Mitsunori Ikeda, Sayumi Nojima, Tatsuo Kaneko
Atopic dermatitis (AD) is a skin disorder characterized by filaggrin (FLG) defect. We evaluated sacran's effects on dust-mite extracts (DME)-induced AD-like disease and also its effect on profilaggrin (proFLG) in a murine model of 2,4-dinitroflurobenze (DNFB)-induced contact hypersensitivity. In the murine AD-like disease model, allergic NC/Nga mice (N=60) were randomly divided into five treatment groups of 12 animals each: 0.2% and 1%sacran; 0.1% Tacrolimus; Vaseline and buffer-treated controls. Blood samples were drawn and serum levels of representative Th-1, Th-2 and also Th-17 (IL-17A) cytokines were assayed by Cytometric Bead Array (CBA)...
May 15, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28514101/rearrangement-of-a-p4-butterfly-complex-the-formation-of-a-homoleptic-phosphorus-iron-sandwich-complex
#10
Julian Müller, Sebastian Heinl, Christoph Schwarzmaier, Gábor Balázs, Martin Keilwerth, Karsten Meyer, Manfred Scheer
The versatile coordination behavior of the P4 butterfly complex [{Cp'''Fe(CO)2 }2 (μ,η(1:1) -P4 )] (1, Cp'''=η(5) -C5 H2(t) Bu3 ) towards different iron(II) compounds is presented. The reaction of 1 with [FeBr2 ⋅dme] (dme=dimethoxyethane) leads to the chelate complex [{Cp'''Fe(CO)2 }2 (μ3 ,η(1:1:2) -P4 ){FeBr2 }] (2), whereas, in the reaction with [Fe(CH3 CN)6 ][PF6 ]2 , an unprecedented rearrangement of the P4 butterfly structural motif leads to the cyclo-P4 moiety in {(Cp'''Fe(CO)2 )2 (μ3 ,η(1:1:4) -P4 )}2 Fe][PF6 ]2 (3)...
May 17, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28512709/influence-of-low-temperature-combustion-and-dimethyl-ether-diesel-blends-on-performance-combustion-and-emission-characteristics-of-common-rail-diesel-engine-a-cfd-study
#11
Venkatesh Tavareppa Lamani, Ajay Kumar Yadav, Kumar Gottekere Narayanappa
Due to presence of more oxygen, absence of carbon-carbon (C-C) bond in chemical structure, and high cetane number of dimethyl ether (DME), pollution from DME operated engine is less compared to diesel engine. Hence, the DME can be a promising alternative fuel for diesel engine. The present study emphasizes the effect of various exhaust gas recirculation (EGR) rates (0-20%) and DME/Diesel blends (0-20%) on combustion characteristics and exhaust emissions of common rail direct injection (CRDI) engine using three-dimensional computational fluid dynamics (CFD) simulation...
May 16, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28510630/local-and-systemic-inflammatory-biomarkers-of-diabetic-retinopathy-an-integrative-approach
#12
Stela Vujosevic, Rafael Simó
Purpose: To review the usefulness of local and systemic inflammatory biomarkers of diabetic retinopathy (DR) to implement a more personalized treatment. Methods: An integrated research (from ophthalmologist and diabetologist point of view) of most significant literature on serum, vitreous, and aqueous humor (AH) biochemical biomarkers related to inflammation at early and advanced stages of DR (including diabetic macular edema [DME] and proliferative DR) was performed...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28508464/arsenic-rich-polyarsenides-stabilized-by-cp-fe-fragments
#13
Monika Schmidt, David Konieczny, Eugenia V Peresypkina, Alexander V Virovets, Gabor Balázs, Michael Bodensteiner, Felix Riedlberger, Hannes Krauss, Manfred Scheer
The redox chemistry of [Cp*Fe(η(5) -As5 )] (1, Cp*=η(5) -C5 Me5 ) has been investigated by cyclic voltammetry, revealing a redox behavior similar to that of its lighter congener [Cp*Fe(η(5) -P5 )]. However, the subsequent chemical reduction of 1 by KH led to the formation of a mixture of novel Asn scaffolds with n up to 18 that are stabilized only by [Cp*Fe] fragments. These include the arsenic-poor triple-decker complex [K(dme)2 ][{Cp*Fe(μ,η(2:2) -As2 )}2 ] (2) and the arsenic-rich complexes [K(dme)3 ]2 [(Cp*Fe)2 (μ,η(4:4) -As10 )] (3), [K(dme)2 ]2 [(Cp*Fe)2 (μ,η(2:2:2:2) -As14 )] (4), and [K(dme)3 ]2 [(Cp*Fe)4 (μ4 ,η(4:3:3:2:2:1:1) -As18 )] (5)...
May 16, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28508191/investigations-of-severity-level-measurements-for-diabetic-macular-oedema-using-machine-learning-algorithms
#14
S Murugeswari, R Sukanesh
BACKGROUND: The macula is an important part of the human visual system and is responsible for clear and colour vision. Macular oedema happens when fluid and protein deposit on or below the macula of the eye and cause the macula to thicken and swell. Normally, it occurs due to diabetes called diabetic macular oedema. Diabetic macular oedema (DME) is one of the main causes of visual impairment in patients. AIM: The aims of the present study are to detect and localize abnormalities in blood vessels with respect to macula in order to prevent vision loss for the diabetic patients...
May 15, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28503894/revaling-the-direct-mechanism-of-the-first-carbon-carbon-bond-formation-in-methanol-to-hydrocarbons-process
#15
Xinqiang Wu, Shutao Xu, Wenna Zhang, Jindou Huang, Jinzhe Li, Bowen Yu, Yingxu Wei, Zhongmin Liu
In the past two decades, the reaction mechanism of C-C bond formation from methanol or dimethyl ether (DME) has been intensively studied as the most critical problem of methanol to hydrocarbons (MTH) process, one of the most important reactions in C1 chemistry, but the first C-C bond generation during the very initial reaction stage remains a highly controversial issue. For the first time, a surface methyleneoxy-analogue, originated from the surface activated DME, was directly observed by in situ solid-state NMR and recognized to be the crucial intermediate for the first C-C bond formation in MTH process...
May 15, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28499163/the-diabetic-retinopathy-barometer-study-global-perspectives-on-access-to-and-experiences-of-diabetic-retinopathy-screening-and-treatment
#16
D Cavan, L Makaroff, J da Rocha Fernandes, M Sylvanowicz, P Ackland, J Conlon, D Chaney, A Malhi, J Barratt
AIM: To assess the level of awareness, prevention and treatment of Diabetic Eye Disease (DED) comprising Diabetic Retinopathy (DR) and Diabetic Macula Edema (DME) retinopathy among adults with diabetes and health professionals. METHODS: The Diabetic Retinopathy Barometer Study consisted of a qualitative study, which consisted of semi-structured interviews, and a quantitative study using online surveys for adults with diabetes and for health professionals. RESULTS: A total of 4340 adults with diabetes and 2329 health professionals participated in the surveys...
April 4, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28499051/safety-and-efficacy-of-ziv-aflibercept-in-the-treatment-of-refractory-diabetic-macular-edema
#17
Mohammed Ashraf, Hassan El Kayal, Ahmed A R Souka
BACKGROUND AND OBJECTIVE: To evaluate the safety and efficacy of ziv-aflibercept (Zaltrap; Sanofi-Aventis, Bridgewater, NJ/Regeneron Pharmaceuticals, Tarrytown, NY) in the treatment of refractory diabetic macular edema (DME). PATIENTS AND METHODS: Retrospective case series looking at the safety of ziv-aflibercept in patients with DME refractory to previous anti-vascular endothelial growth factor (VEGF) therapy. Detailed ophthalmologic examination, best-corrected visual acuity, and optical coherence tomography measurements were performed pre-switch, as well as at each monthly follow-up visit...
May 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28494591/in-situ-multimodal-3d-chemical-imaging-of-a-hierarchically-structured-core-shell-catalyst
#18
Thomas L Sheppard, Stephen W T Price, Federico Benzi, Sina Baier, Michael Klumpp, Roland Dittmeyer, Wilhelm Schwieger, Jan-Dierk Grunwaldt
A Cu/ZnO/Al2O3@ZSM-5 core@shell catalyst active for one-step conversion of synthesis gas to dimethyl ether was imaged simultaneously and in situ using synchrotron-based X-ray Fluorescence (μ-XRF), X-ray Diffraction (μ-XRD) and Scanning Transmission X-ray Microscopy (STXM) Computed Tomography (CT) with micrometer spatial reso-lution. An identical sample volume was imaged stepwise, first under oxidizing and reducing atmospheres (imitating calcination and activation processes), and then under model reaction conditions for DME synthesis (H2:CO:CO2 ratio of 16:8:1, up to 250 °C)...
May 12, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28492920/cost-effectiveness-of-intravitreous-ranibizumab-compared-with-panretinal-photocoagulation-for-proliferative-diabetic-retinopathy-secondary-analysis-from-a-diabetic-retinopathy-clinical-research-network-randomized-clinical-trial
#19
David W Hutton, Joshua D Stein, Neil M Bressler, Lee M Jampol, David Browning, Adam R Glassman
Importance: The Diabetic Retinopathy Clinical Research Network Protocol S randomized clinical trial results suggest that ranibizumab is a reasonable treatment alternative to panretinal photocoagulation (PRP) when managing proliferative diabetic retinopathy (PDR), with or without concomitant baseline diabetic macular edema (DME). However, ranibizumab injections are costly. Thus, it would be useful to examine the relative cost-effectiveness of these 2 treatment modalities. Objective: To evaluate incremental cost-effectiveness ratios of 0...
May 8, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28491039/daily-moderate-exercise-is-beneficial-and-social-stress-is-detrimental-to-disease-pathology-in-murine-lupus-nephritis
#20
Saba I Aqel, Jeffrey M Hampton, Michael Bruss, Kendra T Jones, Giancarlo R Valiente, Lai-Chu Wu, Matthew C Young, William L Willis, Stacy Ardoin, Sudha Agarwal, Brad Bolon, Nicole Powell, John Sheridan, Naomi Schlesinger, Wael N Jarjour, Nicholas A Young
Daily moderate exercise (DME) and stress management are underemphasized in the care of patients with lupus nephritis (LN) due to a poor comprehensive understanding of their potential roles in controlling the inflammatory response. To investigate these effects on murine LN, disease progression was monitored with either DME or social disruption stress (SDR) induction in NZM2410/J mice, which spontaneously develop severe, early-onset LN. SDR of previously established social hierarchies was performed daily for 6 days and DME consisted of treadmill walking (8...
2017: Frontiers in Physiology
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