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https://www.readbyqxmd.com/read/29781853/the-use-of-pedicled-perforator-flaps-in-chest-reconstruction-a-systematic-review-of-outcomes-and-reliability
#1
Anne-Sophie Florczak, Benoit Chaput, Christian Herlin, Pascal Rousseau, Eric Watier, Nicolas Bertheuil
BACKGROUND: In recent years, pedicled perforator flaps have revolutionized plastic surgery by reducing donor site morbidity and ensuring larger and deeper reconstructions with local pedicled cutaneous flaps. The aim of the study was to make a systematic review of perforator pedicled propeller flaps (PPPFs) in chest reconstruction. METHODS: Pubmed and Cochrane databases were searched from 1989 to October 2016 for articles describing the use of PPPFs in chest reconstruction...
May 17, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29781208/a-useful-alternative-surgical-technique-to-reconstructing-large-defects-following-excision-of-recurrent-pilonidal-sinus-disease-in-the-intergluteal-region-an-operative-approach-for-the-transverse-lumbar-artery-perforator-flap
#2
Alethea My Tan, Zeeshan Ahmad, Charles Yy Loh, Sonya Gardiner, Bhagwat Mathur
The reconstruction of defects in the intergluteal region following pilonidal sinus excision is challenging due to its anatomical location, close proximity to the anus, and being a high-tension area prone to wound-healing problems. Excision and primary closure is known to carry a higher risk of recurrence and subsequent complications compared with using nearby local healthy tissue, such as a flap, to reconstruct defect. Extra due diligence should be given to patient selection and flap choice when deciding the reconstruction of a defect...
May 21, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29780928/spontaneous-regression-of-epithelial-downgrowth-from-clear-corneal-phacoemulsification-wound
#3
Ryan M Jaber, Mark Harrod, Jeffrey M Goshe
Purpose: To report a case of spontaneous regression of optical coherence tomography (OCT) and confocal microscopy-supported epithelial downgrowth associated with clear corneal phacoemulsification wound. Observations: A 66-year-old Caucasian male presented two years after phacoemulsification in the left eye with an enlarging cornea endothelial lesion in that eye. His early post-operative course had been complicated by corneal edema and iris transillumination defects...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29776969/identifying-genetic-players-in-cell-sheet-morphogenesis-using-a-drosophila-deficiency-screen-for-genes-on-chromosome-2r-involved-in-dorsal-closure
#4
Richard D Mortensen, Regan P Moore, Stephanie M Fogerson, Hellen Y Chiou, Chimdindu V Obinero, Neel K Prabhu, Angela H Wei, Janice M Crawford, Daniel P Kiehart
Cell sheet morphogenesis characterizes key developmental transitions and homeostasis, in vertebrates and throughout phylogeny, including gastrulation, neural tube formation and wound healing. Dorsal closure, a process during Drosophila embryogenesis, has emerged as a model for cell sheet morphogenesis. ∼140 genes are currently known to affect dorsal closure and new genes are identified each year. Many of these genes were identified in screens that resulted in arrested development. Dorsal closure is remarkably robust and many questions regarding the molecular mechanisms involved in this complex biological process remain...
May 18, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29776425/combined-application-of-latissimus-dorsi-myocutaneous-flap-and-iliac-bone-flap-in-the-treatment-of-chronic-osteomyelitis-of-the-lower-extremity
#5
Jihui Ju, Lei Li, Rong Zhou, Ruixing Hou
BACKGROUND: To evaluate the clinical efficacy and safety of latissimus dorsi myocutaneous flap (stage I) combined with iliac bone flap (stage II) in the treatment of chronic osteomyelitis of the lower extremity. METHODS: Clinical data of 18 patients undergoing latissimus dorsi myocutaneous flap in combination with iliac bone flap grafting were retrospectively analyzed. Among them, 2 patients developed chronic osteomyelitis of the lower segment of the femur, 4 were diagnosed with chronic osteomyelitis of the tibial plateau, and 12 with chronic osteomyelitis of the lower segment of the tibia...
May 18, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29771377/alternative-splicing-analysis-in-human-monocytes-and-macrophages-reveals-mbnl1-as-major-regulator
#6
Hongfei Liu, Paolo A Lorenzini, Fan Zhang, Shaohai Xu, Mei Su M Wong, Jie Zheng, Xavier Roca
We report the detailed transcriptomic profiles of human innate myeloid cells using RNA sequencing. Monocytes migrate from blood into infected or wounded tissue to differentiate into macrophages, and control inflammation via phagocytosis or cytokine secretion. We differentiated culture primary monocytes with either GM- or M-CSF to obtain pro- or anti-inflammatory macrophages, and respectively activated them with either LPS/IFNγ or anti-inflammatory cytokines. We also treated the THP-1 monocytic cell line with PMA and similar cytokines to mimic differentiation and activation...
May 16, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29765486/use-of-hyaluronic-acid-based-biological-bilaminar-matrix-in-wound-bed-preparation-a-case-series
#7
Richard Simman, Walid Mari, Sara Younes, Michael Wilson
Objective: Hyalomatrix, a matrix that consists of esterified hyaluronic acid, covered with a removable, semipermeable silicone top layer, was used to generate granulation tissue in a series of 12 serious, surgical wounds of different etiologies. Methods: Many defects showed exposed muscle, tendons, and/or bone. After thorough debridement, the matrix was applied, in a number of cases, combined with negative pressure wound therapy. Results: All wounds developed granulation tissue in and on top of the matrix. Nine wounds were then closed with a split skin autograft...
2018: Eplasty
https://www.readbyqxmd.com/read/29762451/modified-design-of-anterolateral-thigh-flap-for-total-pharyngolaryngectomy-reconstruction-a-single-center-experience
#8
Li-Yen Cheng, Cha-Chun Chen, Hwang-Chi Lin, Chu-Hsu Jeng, Shang-Hsi Lin, Wei-Nung Jim Chen, Yu-Hsien Lin, Sheng-Po Hao
BACKGROUND: Defects after total pharyngolaryngectomy for hypopharyngeal cancer often require reconstruction via free tissue transfer. Recently, anterolateral thigh (ALT) flap has become the gold standard in many centers because of its advantages with respect to versatility, minimal donor-site morbidity, good speech quality, and relatively low fistula and anastomotic leakage rates. Moreover, ALT allows 2 surgical teams to work simultaneously. However, the height of the parallelogram in the ALT design for neoesophagus reconstruction is usually set at a minimum of 9...
May 14, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29762440/reconstruction-of-extensive-post-electric-burn-scalp-defects-with-exposed-bones-a-study-of-12-cases
#9
Periakaruppan Jeyakumar, Alia T Hussain, Ashik R Ahamed
The scalp is a unique part of the human body with respect to its shape and position. It is the part of the body that is usually exposed in its original form, with no covering by any means of clothing. In workplaces, especially in the electrical industry in the area of electrical substations and power transmission lines it is this part of the body that can easily come in contact with high tension electrical wires. Others who can be prone to suffer such injuries are pedestrians, people working on heights, ladies hanging clothes on terraces...
May 14, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29762438/venous-anastomoses-in-anterolateral-thigh-flaps-for-the-lower-extremity-vessel-selection-in-lieu-of-obligatory-number
#10
David Mattos, Shawn Diamond, Anmol S Chattha, Johanna N Riesel, Matthew L Iorio
BACKGROUND: Dual venous drainage for anterolateral thigh flaps has been proposed to protect against flap-related complications in head and neck applications. Here we report our experience with single vs dual venous anastomosis during lower extremity free-tissue transfer. METHODS: All free anterolateral thigh flaps for lower extremity reconstruction from 2011 to 2017 were retrospectively reviewed. An algorithm was used to determine the type and number of venous anastomoses, emphasizing patient anatomy, venous quality, and size match...
May 14, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29762280/long-term-outcomes-of-pedicled-gastrocnemius-flaps-in-total-knee-arthroplasty
#11
Matthew T Houdek, Eric R Wagner, Cody C Wyles, William S Harmsen, Arlen D Hanssen, Michael J Taunton, Steven L Moran
BACKGROUND: Deficient soft tissue following total knee arthroplasty (TKA) can jeopardize outcome. The gastrocnemius flap is an important means of providing coverage of a knee with deficient soft tissue. There is a paucity of long-term studies on the use of the gastrocnemius flap in the setting of TKA. The purpose of this study was to review the outcomes after the use of pedicled gastrocnemius flaps for coverage of a soft-tissue defect at the time of TKA. METHODS: Eighty-three patients in whom a gastrocnemius flap had been used to cover the site of a primary (n = 18) or revision (n = 65) TKA over a 25-year period were identified...
May 16, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29759951/immediate-and-long-term-results-of-unsintered-hydroxyapatite-and-poly-l-lactide-composite-sheets-for-orbital-wall-fracture-reconstruction
#12
Keishi Kohyama, Yoko Morishima, Koki Arisawa, Yuko Arisawa, Hisakazu Kato
INTRODUCTION: Bone defect reconstruction in orbital wall fractures with absorbable alloplastic such as the unsintered hydroxyapatite and poly L-lactide composite (u-HA/PLLA) system is gaining popularity. The u-HA/PLLA material has osteoconductive and osteosynthetic properties. However, quantitative, long-term outcome data after the use of u-HA/PLLA for orbital wall fractures are lacking. PATIENTS AND METHODS: We retrospectively analyzed 115 patients who underwent surgical repair of orbital wall fractures with a u-HA/PLLA sheet from 2011 to 2016...
March 28, 2018: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29758367/clinical-and-neurosurgical-management-of-cranial-machete-injuries-the-experience-of-a-tertiary-referral-center-in-nicaragua
#13
Luis Zapata, Ernest J Wright, Peter Nakaji
BACKGROUND: The neurosurgical literature rarely describes managing open head injuries caused by machetes, although this is a common head injury in developing countries. We present our experience managing cranial machete injuries in Nicaragua over a 5-year period. METHODS: A retrospective chart review identified patients admitted to a neurosurgery service for cranial machete injury. RESULTS: Among 51 patients studied, the majority (n=42, 82%) presented with mild neurological deficits (Glasgow Coma Scale score ≥14)...
May 11, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29757664/reverse-saphenous-conduit-flap-in-19-dogs-and-1-cat
#14
Jacqueline V J Cavalcanti, Sabrina L Barry, Otto I Lanz, Katherine Barnes, Julia V Coutin
The purpose of this retrospective study was to report the outcomes of 19 dogs and 1 cat undergoing reverse saphenous conduit flap between 1999 and 2016. Reverse saphenous conduit flap was used to treat traumatic wounds and wounds resulting from tumor excision in the hind limb; the majority of cases had medial shearing injuries. All animals had complete flap survival. In five animals (20%), minor donor site dehiscence occurred, which did not require surgery. Other postoperative complications included signs of severe venous congestion in one dog...
May 14, 2018: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/29755905/a-case-of-neurotrophic-keratopathy-concomitant-to-brain-metastasis
#15
Chiara Bonzano, Elisabetta Bonzano, Carlo Alberto Cutolo, Riccardo Scotto, Carlo Enrico Traverso
We report a case of a 63-year-old Caucasian female referred to the cornea service of Clinica Oculistica with a neurotrophic corneal ulcer, decreased corneal sensitivity, absent corneal reflex, and decreased lacrimation. The medical record review was relevant for mastectomy and adjuvant therapy for breast cancer complicated by pontocerebellar angle metastasis. Eye patching and application of antibiotic and vitamin ointments were prescribed at first, without a significant improvement. Thus, treatment with autologous serum was started...
March 12, 2018: Curēus
https://www.readbyqxmd.com/read/29744191/synergistic-effects-of-the-combined-use-of-human-cultured-periosteal-sheets-and-platelet-rich-fibrin-on-bone-regeneration-an-animal-study
#16
Makoto Horimizu, Takehiko Kubota, Tomoyuki Kawase, Masaki Nagata, Mito Kobayashi, Kazuhiro Okuda, Koh Nakata, Hiromasa Yoshie
A human-cultured alveolar bone-derived periosteal (hCP) sheet is an osteogenic grafting material used clinically in periodontal regenerative therapy, while platelet-rich fibrin (PRF), a platelet concentrate with fibrin clot, is considered to augment the wound healing process. Therefore, whether the combined use of hCP-PRF complex could facilitate bone regeneration synergistically was evaluated in animal models. Human periosteal segments (1 × 1 mm) were cultured initially on plastic dishes and formed an hCP sheet...
August 2017: Clinical and Experimental Dental Research
https://www.readbyqxmd.com/read/29742977/the-thyroid-hormone-receptors-regulate-the-expression-of-micrornas-with-key-roles-in-skin-homeostasis
#17
Lidia Ruiz-Llorente, Constanza Contreras-Jurado, Mónica Martínez-Fernández, Jesus Maria Paramio, Ana Aranda
BACKGROUND: MicroRNAs (miRNAs) play a unique role in posttranscriptional regulation of gene expression and control different aspects of skin development, homeostasis and disease. Although it is generally accepted that thyroid hormones signaling is important in skin pathophysiology, the role of their nuclear receptors (TRs) in cutaneous miRNA expression has yet to be explored. METHODS: We have used RNAseq to compare the skin miRnome of wild-type mice and genetically modified mice lacking both TRα1 and TRβ, the main thyroid hormone binding isoforms...
May 10, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29740873/customized-reconstruction-with-modified-keystone-flaps
#18
Jang Won Lee, Chan Woo Kim, Tae Hwan Park
The reconstruction of soft tissue defects with a similar type of tissue and minimizing morbidities are important. Herein, we describe our surgical experience using customized reconstruction with a series of modified keystone flaps. We retrospectively reviewed data of 48 consecutive soft tissue reconstructions using modified keystone flaps between March and December 2017. Soft tissue reconstruction was performed and there was no major complication in the follow-up period. The dimensions of the wound defect ranged from 1 × 1 cm2 to 20 × 18 cm2 with a mean size of 4...
May 9, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/29737002/lower-limb-reconstruction-with-chimeric-flaps-the-quad-flap
#19
Solomon M Azouz, Nikki A Castel, Aparna Vijayasekaran, Alanna M Rebecca, Salvatore C Lettieri
Early soft-tissue coverage is critical for treating traumatic open lower-extremity wounds. As free-flap reconstruction evolves, injuries once thought to be nonreconstructable are being salvaged. Free-tissue transfer is imperative when there is extensive dead space or exposure of vital structures such as bone, tendon, nerves, or blood vessels. We describe 2 cases of lower-extremity crush injuries salvaged with the quad flap. This novel flap consists of parascapular, scapular, serratus, and latissimus dorsi free flaps in combination on one pedicle...
May 7, 2018: Microsurgery
https://www.readbyqxmd.com/read/29734445/a-multicenter-analysis-examining-patients-undergoing-conversion-of-implant-based-breast-reconstruction-to-abdominally-based-free-tissue-transfer
#20
Ruya Zhao, Bao Ngoc N Tran, Andres F Doval, Gloria Broadwater, Kate J Buretta, Jonah P Orr, Bernard T Lee, Scott T Hollenbeck
BACKGROUND:  Breast implant placement is the most common method for postmastectomy reconstruction. For patients who develop complications associated with implant-based reconstruction, additional surgeries may be challenging. This study examined implant-based reconstruction failure in patients undergoing salvage with abdominal free tissue transfer. METHODS:  We conducted an Institutional Review Board approved, multicenter retrospective study of patients with implant-based primary breast reconstruction followed by implant removal and subsequent abdominal free tissue transfer between 2006 and 2016...
May 7, 2018: Journal of Reconstructive Microsurgery
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