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JOURNAL ARTICLE
Javier Perez-Garcia, Maria Pino-Yanes, Elizabeth G Plender, Jamie L Everman, Celeste Eng, Nathan D Jackson, Camille M Moore, Kenneth B Beckman, Vivian Medina, Sunita Sharma, Daniel Efrain Winnica, Fernando Holguin, José Rodríguez-Santana, Jesús Villar, Elad Ziv, Max A Seibold, Esteban G Burchard
BACKGROUND: Albuterol is the first-line asthma medication used in diverse populations. Although DNA methylation (DNAm) is an epigenetic mechanism involved in asthma and bronchodilator drug response (BDR), no study has assessed whether albuterol could induce changes in the airway epithelial methylome. We aimed to characterize albuterol-induced DNAm changes in airway epithelial cells, and assess potential functional consequences and the influence of genetic variation and asthma-related clinical variables...
October 3, 2023: Clinical Epigenetics
#22
REVIEW
Ami Shah, Rachel L Miller
PURPOSE OF REVIEW: Prenatal and childhood exposure to synthetic chemicals, such as phenols and phthalates, have been linked to asthma and allergy, but the extent of this association and the underlying mechanisms are not fully understood. Here we provide an up-to-date review of the evidence linking phenol and phthalate exposure with childhood asthma and allergy and of proposed mechanistic pathways. RECENT FINDINGS: Five experimental and 12 epidemiological studies that examined associations between exposures to synthetic chemicals to asthma and allergic diseases were included...
September 28, 2023: Current Environmental Health Reports
#23
REVIEW
Denitsa Vasileva, Celia M T Greenwood, Denise Daley
DNA methylation (DNAm) is a dynamic, age-dependent epigenetic modification that can be used to study interactions between genetic and environmental factors. Environmental exposures during critical periods of growth and development may alter DNAm patterns, leading to increased susceptibility to diseases such as asthma and allergies. One method to study the role of DNAm is the epigenetic clock-an algorithm that uses DNAm levels at select age-informative Cytosine-phosphate-Guanine (CpG) dinucleotides to predict epigenetic age (EA)...
August 29, 2023: Genes
#24
REVIEW
Andres Cardenas, Raj Fadadu, Supinda Bunyavanich
Human epigenetic variation is associated with both environmental exposures and allergic diseases and can potentially serve as a biomarker connecting climate change with allergy and airway diseases. In this narrative review, we summarize recent human epigenetic studies examining exposure to temperature, precipitation, extreme weather events, and malnutrition to discuss findings as they relate to allergic and airway diseases. Temperature has been the most widely studied exposure, with the studies implicating both short-term and long-term exposure with epigenetic alterations and epigenetic aging...
September 21, 2023: Journal of Allergy and Clinical Immunology
#25
JOURNAL ARTICLE
Latha Kadalayil, Md Zahangir Alam, Cory Haley White, Akram Ghantous, Esther Walton, Olena Gruzieva, Simon Kebede Merid, Ashish Kumar, Ritu P Roy, Olivia Solomon, Karen Huen, Brenda Eskenazi, Peter Rzehak, Veit Grote, Jean-Paul Langhendries, Elvira Verduci, Natalia Ferre, Darek Gruszfeld, Lu Gao, Weihua Guan, Xuehuo Zeng, Enrique F Schisterman, John F Dou, Kelly M Bakulski, Jason I Feinberg, Munawar Hussain Soomro, Giancarlo Pesce, Nour Baiz, Elena Isaevska, Michelle Plusquin, Marina Vafeiadi, Theano Roumeliotaki, Sabine A S Langie, Arnout Standaert, Catherine Allard, Patrice Perron, Luigi Bouchard, Evelien R van Meel, Janine F Felix, Vincent W V Jaddoe, Paul D Yousefi, Cecilia H Ramlau-Hansen, Caroline L Relton, Elmar W Tobi, Anne P Starling, Ivana V Yang, Maria Llambrich, Gillian Santorelli, Johanna Lepeule, Lucas A Salas, Mariona Bustamante, Susan L Ewart, Hongmei Zhang, Wilfried Karmaus, Stefan Röder, Ana Claudia Zenclussen, Jianping Jin, Wenche Nystad, Christian M Page, Maria Magnus, Dereje D Jima, Cathrine Hoyo, Rachel L Maguire, Tuomas Kvist, Darina Czamara, Katri Räikkönen, Tong Gong, Vilhelmina Ullemar, Sheryl L Rifas-Shiman, Emily Oken, Catarina Almqvist, Robert Karlsson, Jari Lahti, Susan K Murphy, Siri E Håberg, Stephanie London, Gunda Herberth, Hasan Arshad, Jordi Sunyer, Regina Grazuleviciene, Dana Dabelea, Régine P M Steegers-Theunissen, Ellen A Nohr, Thorkild I A Sørensen, Liesbeth Duijts, Marie-France Hivert, Vera Nelen, Maja Popovic, Manolis Kogevinas, Tim S Nawrot, Zdenko Herceg, Isabella Annesi-Maesano, M Daniele Fallin, Edwina Yeung, Carrie V Breton, Berthold Koletzko, Nina Holland, Joseph L Wiemels, Erik Melén, Gemma C Sharp, Matt J Silver, Faisal I Rezwan, John W Holloway
BACKGROUND: Seasonal variations in environmental exposures at birth or during gestation are associated with numerous adult traits and health outcomes later in life. Whether DNA methylation (DNAm) plays a role in the molecular mechanisms underlying the associations between birth season and lifelong phenotypes remains unclear. METHODS: We carried out epigenome-wide meta-analyses within the Pregnancy And Childhood Epigenetic Consortium to identify associations of DNAm with birth season, both at differentially methylated probes (DMPs) and regions (DMRs)...
September 11, 2023: Clinical Epigenetics
#26
JOURNAL ARTICLE
Hans Bisgaard, Marianne Mikkelsen, Morten Arendt Rasmussen, Astrid Sevelsted, Ann-Marie Malby Schoos, Nicklas Brustad, Anders U Eliasen, Jonathan Thorsen, Bo Chawes, Gözde Gürdeniz, Andreanne Morin, Ken Stark, Jakob Stokholm, Carole Ober, Casper Emil Tingskov Pedersen, Klaus Bønnelykke
BACKGROUND: We recently conducted a double-blinded randomised controlled trial showing that fish-oil supplementation during pregnancy reduced the risk of persistent wheeze or asthma in the child by 30%. Here, we explore the mechanisms of the intervention. METHODS: 736 pregnant women were given either placebo or n-3 long-chain polyunsaturated fatty acids (LCPUFAs) in the third trimester in a randomised controlled trial. Deep clinical follow-up of the 695 children in the trial was done at 12 visits until age 6 years, including assessment of genotype at the fatty acid desaturase (FADS) locus, plasma fatty acids, airway DNA methylation, gene expression, microbiome and metabolomics...
September 11, 2023: Thorax
#27
JOURNAL ARTICLE
Zhaozhong Zhu, Yijun Li, Robert J Freishtat, Juan C Celedón, Janice A Espinola, Brennan Harmon, Andrea Hahn, Carlos A Camargo, Liming Liang, Kohei Hasegawa
Bronchiolitis is the most common lower respiratory infection in infants, yet its pathobiology remains unclear. Here we present blood DNA methylation data from 625 infants hospitalized with bronchiolitis in a 17-center prospective study, and associate them with disease severity. We investigate differentially methylated CpGs (DMCs) for disease severity. We characterize the DMCs based on their association with cell and tissues types, biological pathways, and gene expression. Lastly, we also examine the relationships of severity-related DMCs with respiratory and immune traits in independent cohorts...
September 7, 2023: Nature Communications
#28
JOURNAL ARTICLE
Negusse Tadesse Kitaba, Gerd Toril Mørkve Knudsen, Ane Johannessen, Faisal I Rezwan, Andrei Malinovschi, Anna Oudin, Bryndis Benediktsdottir, David Martino, Francisco Javier Callejas González, Leopoldo Palacios Gómez, Mathias Holm, Nils Oskar Jõgi, Shyamali C Dharmage, Svein Magne Skulstad, Sarah H Watkins, Matthew Suderman, Francisco Gómez-Real, Vivi Schlünssen, Cecilie Svanes, John W Holloway
BACKGROUND: Experimental studies suggest that exposures may impact respiratory health across generations via epigenetic changes transmitted specifically through male germ cells. Studies in humans are, however, limited. We aim to identify epigenetic marks in offspring associated with father's preconception smoking. METHODS: We conducted epigenome-wide association studies (EWAS) in the RHINESSA cohort (7-50 years) on father's any preconception smoking (n = 875 offspring) and father's pubertal onset smoking < 15 years (n = 304), using Infinium MethylationEPIC Beadchip arrays, adjusting for offspring age, own smoking and maternal smoking...
August 31, 2023: Clinical Epigenetics
#29
JOURNAL ARTICLE
Chinonye Doris Onuzulu, Samantha Lee, Sujata Basu, Jeannette Comte, Yan Hai, Nikho Hizon, Shivam Chadha, Maria Shenna Fauni, Shana Kahnamoui, Bo Xiang, Andrew J Halayko, Vernon W Dolinsky, Christopher Pascoe, Meaghan J Jones
Prenatal and early life exposure to cigarette smoke (CS) have repeatedly been shown to induce stable, long-term changes in DNA methylation (DNAm) in offspring. It has been hypothesized that these changes might be functionally related to the known outcomes of prenatal and early life CS exposure, which include impaired lung development, altered lung function and increased risk of asthma and wheeze. However, to date, few studies have examined DNAm changes induced by prenatal CS in tissues of the lung, and even fewer have attempted to examine the specific influences of prenatal versus early postnatal exposures...
August 29, 2023: American Journal of Physiology. Lung Cellular and Molecular Physiology
#30
JOURNAL ARTICLE
Aniruddha Rathod, Rajesh Melaram, Hongmei Zhang, Hasan Arshad, Susan Ewart, Meredith Ray, Caroline L Relton, Wilfried Karmaus, John W Holloway
No abstract text is available yet for this article.
August 28, 2023: Clinical and Experimental Allergy
#31
REVIEW
Sergio de Jesus Romero-Tapia, José Raúl Becerril-Negrete, Jose A Castro-Rodriguez, Blanca E Del-Río-Navarro
The clinical manifestations of asthma in children are highly variable, are associated with different molecular and cellular mechanisms, and are characterized by common symptoms that may diversify in frequency and intensity throughout life. It is a disease that generally begins in the first five years of life, and it is essential to promptly identify patients at high risk of developing asthma by using different prediction models. The aim of this review regarding the early prediction of asthma is to summarize predictive factors for the course of asthma, including lung function, allergic comorbidity, and relevant data from the patient's medical history, among other factors...
August 20, 2023: Journal of Clinical Medicine
#32
JOURNAL ARTICLE
Kathryn Recto, Priyadarshini Kachroo, Tianxiao Huan, David Van Den Berg, Gha Young Lee, Helena Bui, Dong Heon Lee, Jessica Gereige, Chen Yao, Shih-Jen Hwang, Roby Joehanes, Scott T Weiss, George T O'Connor, Daniel Levy, Dawn L DeMeo
BACKGROUND: Identifying novel epigenetic signatures associated with serum immunoglobulin E (IgE) may improve our understanding of molecular mechanisms underlying asthma and IgE-mediated diseases. METHODS: We performed an epigenome-wide association study using whole blood from Framingham Heart Study (FHS; n = 3,471, 46% females) participants and validated results using the Childhood Asthma Management Program (CAMP; n = 674, 39% females) and the Genetic Epidemiology of Asthma in Costa Rica Study (CRA; n = 787, 41% females)...
September 2023: EBioMedicine
#33
REVIEW
Andres Cardenas, Raj P Fadadu, Gerard H Koppelman
The epigenome is at the intersection of the environment, genotype, and cellular response. DNA methylation of cytosine nucleotides, the most studied epigenetic modification, has been systematically evaluated in human studies using untargeted epigenome-wide association studies (EWAS) and shown to be both sensitive to environmental exposures and associated with allergic diseases. In this narrative review, we summarize findings from key EWAS previously conducted on this topic, interpret results from recent studies, and discuss the strengths, challenges, and opportunities regarding epigenetics research on the environment-allergy relationship...
June 7, 2023: Journal of Allergy and Clinical Immunology
#34
JOURNAL ARTICLE
Soyeon Kim, Zhongli Xu, Erick Forno, Yidi Qin, Hyun Jung Park, Molin Yue, Qi Yan, Michelle Manni, Edna Acosta-Pérez, Glorisa Canino, Wei Chen, Juan C Celedón
BACKGROUND: EQTM (expression quantitative trait methylation) analyses uncover associations between DNA methylation markers and gene expression. Most eQTM analyses of complex diseases have focused on cis-eQTM pairs (within 1 Mb). OBJECTIVE: To identify cis- and trans- methylation markers associated with gene expression in airway epithelium from youth with and without atopic asthma. METHODS: We conducted both cis- and trans-eQTM analyses in nasal (airway) epithelial samples from 158 Puerto Rican youth with atopic asthma and 100 control subjects without atopy or asthma...
June 2, 2023: Journal of Allergy and Clinical Immunology
#35
JOURNAL ARTICLE
Yang Yie Sio, Ping Shi, Sri Anusha Matta, Yu Ting Rachel Fok, Wen Chin Chiang, Yee-How Say, Fook Tim Chew
INTRODUCTION: The arachidonic acid (AA) pathway plays a crucial role in allergic inflammatory diseases; however, the functional roles of allergy-associated single nucleotide polymorphisms (SNPs) in this pathway remain incompletely illustrated. METHODS: This study belongs to a part of an ongoing Singapore/Malaysia cross-sectional genetics and epidemiological study (SMCSGES). We performed population genotyping on n = 2,880 individuals from the SMCSGES cohort to assess the associations of SNPs in the AA pathway genes with asthma and allergic rhinitis (AR)...
May 10, 2023: International Archives of Allergy and Immunology
#36
REVIEW
Shama Ahmad, Xiao Lu Zhang, Aftab Ahmad
Pulmonary disease such as chronic obstructive pulmonary disease (COPD), asthma, pulmonary fibrosis and pulmonary hypertension are the leading cause of deaths. More importantly, lung diseases are on the rise and environmental factors induced epigenetic modifications are major players on this increased prevalence. It has been reported that dysregulation of genes involved in epigenetic regulation such as the histone deacetylase (HDACs) and histone acetyltransferase (HATs) play important role in lung health and pulmonary disease pathogenesis...
May 23, 2023: Seminars in Cell & Developmental Biology
#37
Elizabeth Kicic-Starcevich, David G Hancock, Thomas Iosifidis, Patricia Agudelo-Romero, Jose A Caparros-Martin, Desiree Silva, Lidija Turkovic, Peter N Le Souef, Anthony Bosco, David J Martino, Anthony Kicic, Susan L Prescott, Stephen M Stick
INTRODUCTION: Recurrent wheezing disorders including asthma are complex and heterogeneous diseases that affect up to 30% of all children, contributing to a major burden on children, their families, and global healthcare systems. It is now recognized that a dysfunctional airway epithelium plays a central role in the pathogenesis of recurrent wheeze, although the underlying mechanisms are still not fully understood. This prospective birth cohort aims to bridge this knowledge gap by investigating the influence of intrinsic epithelial dysfunction on the risk for developing respiratory disorders and the modulation of this risk by maternal morbidities, in utero exposures, and respiratory exposures in the first year of life...
May 3, 2023: medRxiv
#38
JOURNAL ARTICLE
Mita T M T Tran, Fu-Chen Kuo, Jie-Ting Low, Yu-Ming Chuang, Sofia Sultana, Wen-Long Huang, Zhe-Young Lin, Guan-Ling Lin, Chia-Fang Wu, Sih-Syuan Li, Jau-Ling Suen, Chih-Hsing Hung, Ming-Tsang Wu, Michael W Y Chan
Recent experimental and observational research has suggested that childhood allergic asthma and other conditions may be the result of prenatal exposure to environmental contaminants, such as di-(2-ethylhexyl) phthalate (DEHP). In a previous epidemiological study, we found that ancestral exposure (F0 generation) to endocrine disruptors or the common plasticizer DEHP promoted allergic airway inflammation via transgenerational transmission in mice from generation F1 to F4. In the current study, we employed a MethylationEPIC Beadchip microarray to examine global DNA methylation in the human placenta as a function of maternal exposure to DEHP during pregnancy...
May 6, 2023: Scientific Reports
#39
JOURNAL ARTICLE
Amy E Howell, Caroline Relton, Richard M Martin, Jie Zheng, Kathreena M Kurian
Genetic evidence suggests glioma risk is altered by leukocyte telomere length, allergic disease (asthma, hay fever or eczema), alcohol consumption, childhood obesity, low-density lipoprotein cholesterol (LDLc) and triglyceride levels. DNA methylation (DNAm) variation influences many of these glioma-related traits and is an established feature of glioma. Yet the causal relationship between DNAm variation with both glioma incidence and glioma risk factors is unknown. We applied a two-step Mendelian randomization (MR) approach and several sensitivity analyses (including colocalization and Steiger filtering) to assess the association of DNAm with glioma risk factors and glioma incidence...
April 21, 2023: Scientific Reports
#40
JOURNAL ARTICLE
Aalekhya Reddam, Valentina Bollati, Haotian Wu, Chiara Favero, Letizia Tarantini, Mirjam Hoxha, Nicole Comfort, Diane R Gold, Wanda Phipatanakul, Andrea A Baccarelli
Human endogenous retroviruses (HERVs) are transposable genomic elements generally repressed through DNA methylation. HERVs can be demethylated and expressed in response to environmental stimuli. Therefore, more research is needed to understand the influence of environmental exposures on HERV methylation. Air pollutants are commonly linked with global hypomethylation, and as HERVs comprise of nearly 8% of repetitive elements in the human genome, our objective was to examine the association between air pollutant exposure and HERV methylation...
April 12, 2023: Toxicological Sciences: An Official Journal of the Society of Toxicology
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