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Carey L Holleran, Patrick W Hennessey, Abigail L Leddy, Gordhan B Mahtani, Gabrielle Brazg, Brian D Schmit, T George Hornby
BACKGROUND AND PURPOSE: Previous data suggest that large amounts of high-intensity stepping training in variable contexts (tasks and environments) may improve locomotor function, aerobic capacity, and treadmill gait kinematics in individuals poststroke. Whether similar training strategies are tolerated and efficacious for patients with other acute-onset neurological diagnoses, such as motor incomplete spinal cord injury (iSCI), is unknown. Individuals with iSCI potentially have greater bilateral impairments...
April 2018: Journal of Neurologic Physical Therapy: JNPT
Mark P Christiansen, Leslie J Klaff, Ron Brazg, Anna R Chang, Carol J Levy, David Lam, Douglas S Denham, George Atiee, Bruce W Bode, Steven J Walters, Lynne Kelley, Timothy S Bailey
BACKGROUND: Persistent use of real-time continuous glucose monitoring (CGM) improves diabetes control in individuals with type 1 diabetes (T1D) and type 2 diabetes (T2D). METHODS: PRECISE II was a nonrandomized, blinded, prospective, single-arm, multicenter study that evaluated the accuracy and safety of the implantable Eversense CGM system among adult participants with T1D and T2D (NCT02647905). The primary endpoint was the mean absolute relative difference (MARD) between paired Eversense and Yellow Springs Instrument (YSI) reference measurements through 90 days postinsertion for reference glucose values from 40 to 400 mg/dL...
January 30, 2018: Diabetes Technology & Therapeutics
Toni L Cordero, Satish K Garg, Ronald Brazg, Timothy S Bailey, John Shin, Scott W Lee, Francine R Kaufman
A 3-month pivotal trial using the MiniMed™ 670G hybrid closed-loop (HCL) system in adolescent and adult patients with type 1 diabetes (T1D), relative to a 2-week baseline run-in period, resulted in increased sensor glucose (SG) values in target range (71-180 mg/dL), reduced HbA1c levels, and no events of diabetic ketoacidosis or severe hypoglycemia ( : NCT02463097). This brief report evaluated how prior continuous glucose monitoring (CGM) experience influenced glycemic outcomes, in the same pivotal trial...
December 2017: Diabetes Technology & Therapeutics
Gabrielle Brazg, Meghan Fahey, Carey L Holleran, Mark Connolly, Jane Woodward, Patrick W Hennessy, Brian D Schmit, T George Hornby
BACKGROUND: Many physical interventions can improve locomotor function in individuals with motor incomplete spinal cord injury (iSCI), although the training parameters that maximize recovery are not clear. Previous studies in individuals with other neurologic injuries suggest the intensity of locomotor training (LT) may positively influence walking outcomes. However, the effects of intensity during training of individuals with iSCI have not been tested. OBJECTIVE: The purpose of this pilot, blinded-assessor randomized trial was to evaluate the effects of LT intensity on walking outcomes in individuals with iSCI...
October 2017: Neurorehabilitation and Neural Repair
Mark P Christiansen, Satish K Garg, Ronald Brazg, Bruce W Bode, Timothy S Bailey, Robert H Slover, Ashley Sullivan, Suiying Huang, John Shin, Scott W Lee, Francine R Kaufman
BACKGROUND: This study evaluated the accuracy and performance of a fourth-generation subcutaneous glucose sensor (Guardian(™) Sensor 3) in the abdomen and arm. METHODS: Eighty-eight subjects (14-75 years of age, mean ± standard deviation [SD] of 42.0 ± 19.1 years) with type 1 or type 2 diabetes participated in the study. Subjects wore two sensors in the abdomen that were paired with either a MiniMed(™) 640G insulin pump, or an iPhone(®) or iPod(®) touch(®) running a glucose monitoring mobile application (Guardian Connect system) and a third sensor in the arm, which was connected to a glucose sensor recorder (GSR)...
August 2017: Diabetes Technology & Therapeutics
Bruce A Buckingham, Timothy S Bailey, Mark Christiansen, Satish Garg, Stuart Weinzimer, Bruce Bode, Stacey M Anderson, Ronald Brazg, Trang T Ly, Francine R Kaufman
BACKGROUND: Predictions based on continuous glucose monitoring (CGM) data are the basis for automatic suspension and resumption of insulin delivery by a predictive low-glucose management feature termed "suspend before low," which is part of the Medtronic MiniMed(®) 640G combined insulin pump and CGM system. This study assessed the safety and performance characteristics of the system in an in-clinic setting at eight sites. MATERIALS AND METHODS: In-clinic standardized increases in basal insulin delivery rates were used to induce nocturnal hypoglycemia in subjects (14-75 years) with type 1 diabetes wearing the MiniMed 640G system...
May 2017: Diabetes Technology & Therapeutics
Gordhan B Mahtani, Catherine R Kinnaird, Mark Connolly, Carey L Holleran, Patrick W Hennessy, Jane Woodward, Gabrielle Brazg, Elliot J Roth, T George Hornby
No abstract text is available yet for this article.
September 16, 2016: Physical Therapy
Satish K Garg, Stuart A Weinzimer, William V Tamborlane, Bruce A Buckingham, Bruce W Bode, Timothy S Bailey, Ronald L Brazg, Jacob Ilany, Robert H Slover, Stacey M Anderson, Richard M Bergenstal, Benyamin Grosman, Anirban Roy, Toni L Cordero, John Shin, Scott W Lee, Francine R Kaufman
BACKGROUND: The safety and effectiveness of the in-home use of a hybrid closed-loop (HCL) system that automatically increases, decreases, and suspends insulin delivery in response to continuous glucose monitoring were investigated. METHODS: Adolescents (n = 30, ages 14-21 years) and adults (n = 94, ages 22-75 years) with type 1 diabetes participated in a multicenter (nine sites in the United States, one site in Israel) pivotal trial. The Medtronic MiniMed® 670G system was used during a 2-week run-in phase without HCL control, or Auto Mode, enabled (Manual Mode) and, thereafter, with Auto Mode enabled during a 3-month study phase...
March 2017: Diabetes Technology & Therapeutics
Elizabeth Yetter, Jared Brazg, Diane Del Valle, Laura Mulvey, Eitan Dickman
Delayed cardiac tamponade (DCT) is a rare and life-threatening complication of catheter ablation performed as a treatment of atrial fibrillation, with few cases described in the medical literature. We present the case of a 57year-old man presenting with DCT 61days following a catheter ablation procedure. To the best of our knowledge, this is the most delayed case of cardiac tamponade (CT) following catheter ablation described in the literature. We also discuss the importance of point of care ultrasound (POCUS) in the diagnosis and treatment of CT...
May 2017: American Journal of Emergency Medicine
Gordhan B Mahtani, Catherine R Kinnaird, Mark Connolly, Carey L Holleran, Patrick W Hennessy, Jane Woodward, Gabrielle Brazg, Elliot J Roth, T George Hornby
BACKGROUND: Common locomotor deficits observed in people poststroke include decreased speeds and abnormal kinematics, characterized by altered symmetry, reduced sagittal-plane joint excursions, and use of compensatory frontal-plane behaviors during the swing phase of gait. Conventional interventions utilized to mitigate these deficits often incorporate low-intensity, impairment-based or functional exercises focused on normalizing kinematics, although the efficacy of these strategies is unclear...
September 15, 2016: Physical Therapy
Tracy Brazg, Taryn Lindhorst, Denise Dudzinski, Benjamin Wilfond
The idea of patient advocacy as a function of clinical ethics consultation (CEC) has been debated in the bioethics literature. In particular, opinion is divided as to whether patient advocacy inherently is in conflict with the other duties of the ethics consultant, especially that of impartial mediator. The debate is complicated, however, because patient advocacy is not uniformly conceptualized. This article examines two literatures that are crucial to understanding patient advocacy in the context of bioethical deliberations: the CEC literature and the literature on advocacy in the social work profession...
2016: Journal of Clinical Ethics
Maureen C Kelley, Tracy Brazg, Benjamin S Wilfond, Liliana J Lengua, Beth E Rivin, Susanne P Martin-Herz, Douglas S Diekema
BACKGROUND: Orphans and vulnerable children (OVCs) represent a significant population worldwide, enduring poor health and living conditions. Evidence-based interventions are needed. However, without parents, ethical concerns about including OVCs in research persist. The aim of our study was to better understand the ethical challenges facing researchers who work with OVCs. METHODS: We conducted semi-structured interviews with 12 international pediatric researchers working with OVCs in seven countries...
May 2016: International Health
David E Ochayon, Boris M Baranovski, Peter Malkin, Ronen Schuster, Noa Kalay, Rotem Ben-Hamo, Ido Sloma, Justin Levinson, Jared Brazg, Sol Efroni, Eli C Lewis, Uri Nevo
Immune tolerance toward "self" is critical in multiple immune disorders. While there are several mechanisms to describe the involvement of immune cells in the process, the role of peripheral tissue cells in that context is not yet clear. The theory of ecoimmunity postulates that interactions between immune and tissue cells represent a predator-prey relationship. A lifelong interaction, shaped mainly during early ontogeny, leads to selection of nonimmune cell phenotypes. Normally, therefore, nonimmune cells that evolve alongside an intact immune system would be phenotypically capable of evading immune responses, and cells whose phenotype falls short of satisfying this steady state would expire under hostile immune responses...
2016: Cell Transplantation
Jared Brazg, Lawrence Haines, Marla C Levine
No abstract text is available yet for this article.
March 2016: American Journal of Emergency Medicine
William Bonadio, Jared Brazg, Nadya Telt, Marybelle Pe, Ferrin Doss, Leah Dancy, Maili Alvarado
BACKGROUND: There is controversy regarding whether in-hospital time delay to appendectomy in children with appendicitis affects risk for perforation. OBJECTIVE: Our aim was to evaluate the impact of time delay from emergency department (ED) presentation to operating room (OR) appendectomy on rates of developing appendiceal perforation in children who present with computed tomography (CT)-confirmed, uncomplicated (no radiographic evidence of perforation) appendicitis...
November 2015: Journal of Emergency Medicine
Jared Brazg, Amber Ruest, Susan Law, Dimitry Bosoy
BACKGROUND: Wernicke encephalopathy is an acute neurological emergency caused by thiamine (vitamin B1) deficiency. The syndrome is associated with a significant morbidity and mortality, and prompt recognition and treatment of the syndrome in the emergency department (ED) is essential to improving patient outcomes. Numerous factors and clinical settings have been identified that predispose a patient to thiamine deficiency and subsequent Wernicke encephalopathy. CASE REPORT: We present the rare case of a 42-year-old man with a recent diagnosis of non-Hodgkin lymphoma who opted against chemotherapy in favor of a 60-day therapeutic water-only fast...
October 2015: Journal of Emergency Medicine
William Bonadio, Peter Peloquin, Jared Brazg, Ilyssa Scheinbach, James Saunders, Chukwujekwu Okpalaji, Peter Homel
OBJECTIVES: Apply multivariate regression analysis to determine the significance of clinical variables for perforation outcome of a large series of preschool aged children with appendicitis. METHODS: Retrospective case review of 180 consecutive children<5 years of age diagnosed with appendicitis during an 8-year period. RESULTS: This age group accounted for only 9% of all cases of pediatric appendicitis at our institution during the study period...
September 2015: Journal of Pediatric Surgery
Jared Brazg, Brian Gillett
No abstract text is available yet for this article.
May 2015: American Journal of Emergency Medicine
Leslie J Klaff, Ronald Brazg, Kristen Hughes, Ann M Tideman, Holly C Schachner, Patricia Stenger, Scott Pardo, Nancy Dunne, Joan Lee Parkes
BACKGROUND: This study evaluated the accuracy of Contour(®) Next (CN; Bayer HealthCare LLC, Diabetes Care, Whippany, NJ) compared with five blood glucose monitoring systems (BGMSs) across a wide range of clinically occurring blood glucose levels. SUBJECTS AND METHODS: Subjects (n=146) were ≥ 18 years and had type 1 or type 2 diabetes. Subjects' glucose levels were safely lowered or raised to provide a wide range of glucose values. Capillary blood samples were tested on six BGMSs and a YSI glucose analyzer (YSI Life Sciences, Inc...
January 2015: Diabetes Technology & Therapeutics
Tracy Brazg, Danae Dotolo, Erika Blacksher
Social work and bioethics are fields deeply committed to cross-disciplinary collaboration to do their respective work. While scholars and practitioners from both fields share a commitment to social justice and to respecting the dignity, integrity and the worth of all persons, the overlap between the fields, including shared values, has received little attention. The purpose of this article is to describe the ways in which greater collaboration between the two fields can broaden their scope, enrich their scholarship, and better ground their practice...
June 2015: Bioethics
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