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https://www.readbyqxmd.com/read/27634921/altered-sagittal-and-frontal-plane-kinematics-following-high-intensity-stepping-training-versus-conventional-interventions-in-subacute-stroke
#1
Gordhan B Mahtani, Catherine R Kinnaird, Mark Connolly, Carey L Holleran, Patrick W Hennessy, Jane Woodward, Gabrielle Brazg, Elliot J Roth, T George Hornby
BACKGROUND: Common locomotor deficits observed in people poststroke include decreased speeds and abnormal kinematics, characterized by altered symmetry, reduced sagittal-plane joint excursions, and use of compensatory frontal-plane behaviors during the swing phase of gait. Conventional interventions utilized to mitigate these deficits often incorporate low-intensity, impairment-based or functional exercises focused on normalizing kinematics, although the efficacy of these strategies is unclear...
September 15, 2016: Physical Therapy
https://www.readbyqxmd.com/read/27333067/-defining-patient-advocacy-for-the-context-of-clinical-ethics-consultation-a-review-of-the-literature-and-recommendations-for-consultants
#2
Tracy Brazg, Taryn Lindhorst, Denise Dudzinski, Benjamin Wilfond
The idea of patient advocacy as a function of clinical ethics consultation (CEC) has been debated in the bioethics literature. In particular, opinion is divided as to whether patient advocacy inherently is in conflict with the other duties of the ethics consultant, especially that of impartial mediator. The debate is complicated, however, because patient advocacy is not uniformly conceptualized. This article examines two literatures that are crucial to understanding patient advocacy in the context of bioethical deliberations: the CEC literature and the literature on advocacy in the social work profession...
2016: Journal of Clinical Ethics
https://www.readbyqxmd.com/read/27178675/ethical-challenges-in-research-with-orphans-and-vulnerable-children-a-qualitative-study-of-researcher-experiences
#3
Maureen C Kelley, Tracy Brazg, Benjamin S Wilfond, Liliana J Lengua, Beth E Rivin, Susanne P Martin-Herz, Douglas S Diekema
BACKGROUND: Orphans and vulnerable children (OVCs) represent a significant population worldwide, enduring poor health and living conditions. Evidence-based interventions are needed. However, without parents, ethical concerns about including OVCs in research persist. The aim of our study was to better understand the ethical challenges facing researchers who work with OVCs. METHODS: We conducted semi-structured interviews with 12 international pediatric researchers working with OVCs in seven countries...
May 2016: International Health
https://www.readbyqxmd.com/read/26850009/experimental-support-for-the-ecoimmunity-theory-distinct-phenotypes-of-nonlymphocytic-cells-in-scid-and-wild-type-mice
#4
David E Ochayon, Boris M Baranovski, Peter Malkin, Ronen Schuster, Noa Kalay, Rotem Ben-Hamo, Ido Sloma, Justin Levinson, Jared Brazg, Sol Efroni, Eli C Lewis, Uri Nevo
Immune tolerance toward "self" is critical in multiple immune disorders. While there are several mechanisms to describe the involvement of immune cells in the process, the role of peripheral tissue cells in that context is not yet clear. The theory of ecoimmunity postulates that interactions between immune and tissue cells represent a predator-prey relationship. A lifelong interaction, shaped mainly during early ontogeny, leads to selection of nonimmune cell phenotypes. Normally, therefore, nonimmune cells that evolve alongside an intact immune system would be phenotypically capable of evading immune responses, and cells whose phenotype falls short of satisfying this steady state would expire under hostile immune responses...
2016: Cell Transplantation
https://www.readbyqxmd.com/read/26341807/omental-torsion-mimicking-perforated-appendicitis-in-a-pediatric-patient-emergency-bedside-sonography
#5
Jared Brazg, Lawrence Haines, Marla C Levine
No abstract text is available yet for this article.
March 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/26166465/impact-of-in-hospital-timing-to-appendectomy-on-perforation-rates-in-children-with-appendicitis
#6
William Bonadio, Jared Brazg, Nadya Telt, Marybelle Pe, Ferrin Doss, Leah Dancy, Maili Alvarado
BACKGROUND: There is controversy regarding whether in-hospital time delay to appendectomy in children with appendicitis affects risk for perforation. OBJECTIVE: Our aim was to evaluate the impact of time delay from emergency department (ED) presentation to operating room (OR) appendectomy on rates of developing appendiceal perforation in children who present with computed tomography (CT)-confirmed, uncomplicated (no radiographic evidence of perforation) appendicitis...
November 2015: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/26104844/a-therapeutic-fast-for-lymphoma-resulting-in-wernicke-encephalopathy
#7
Jared Brazg, Amber Ruest, Susan Law, Dimitry Bosoy
BACKGROUND: Wernicke encephalopathy is an acute neurological emergency caused by thiamine (vitamin B1) deficiency. The syndrome is associated with a significant morbidity and mortality, and prompt recognition and treatment of the syndrome in the emergency department (ED) is essential to improving patient outcomes. Numerous factors and clinical settings have been identified that predispose a patient to thiamine deficiency and subsequent Wernicke encephalopathy. CASE REPORT: We present the rare case of a 42-year-old man with a recent diagnosis of non-Hodgkin lymphoma who opted against chemotherapy in favor of a 60-day therapeutic water-only fast...
October 2015: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/25783356/appendicitis-in-preschool-aged-children-regression-analysis-of-factors-associated-with-perforation-outcome
#8
William Bonadio, Peter Peloquin, Jared Brazg, Ilyssa Scheinbach, James Saunders, Chukwujekwu Okpalaji, Peter Homel
OBJECTIVES: Apply multivariate regression analysis to determine the significance of clinical variables for perforation outcome of a large series of preschool aged children with appendicitis. METHODS: Retrospective case review of 180 consecutive children<5 years of age diagnosed with appendicitis during an 8-year period. RESULTS: This age group accounted for only 9% of all cases of pediatric appendicitis at our institution during the study period...
September 2015: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/25530191/a-hair-raising-diagnosis-goose-bumps-as-sign-of-herpes-simplex-encephalitis
#9
Jared Brazg, Brian Gillett
No abstract text is available yet for this article.
May 2015: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/25260047/accuracy-evaluation-of-contour-next-compared-with-five-blood-glucose-monitoring-systems-across-a-wide-range-of-blood-glucose-concentrations-occurring-in-a-clinical-research-setting
#10
COMPARATIVE STUDY
Leslie J Klaff, Ronald Brazg, Kristen Hughes, Ann M Tideman, Holly C Schachner, Patricia Stenger, Scott Pardo, Nancy Dunne, Joan Lee Parkes
BACKGROUND: This study evaluated the accuracy of Contour(®) Next (CN; Bayer HealthCare LLC, Diabetes Care, Whippany, NJ) compared with five blood glucose monitoring systems (BGMSs) across a wide range of clinically occurring blood glucose levels. SUBJECTS AND METHODS: Subjects (n=146) were ≥ 18 years and had type 1 or type 2 diabetes. Subjects' glucose levels were safely lowered or raised to provide a wide range of glucose values. Capillary blood samples were tested on six BGMSs and a YSI glucose analyzer (YSI Life Sciences, Inc...
January 2015: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/25066240/finding-a-seat-at-the-table-together-recommendations-for-improving-collaboration-between-social-work-and-bioethics
#11
Tracy Brazg, Danae Dotolo, Erika Blacksher
Social work and bioethics are fields deeply committed to cross-disciplinary collaboration to do their respective work. While scholars and practitioners from both fields share a commitment to social justice and to respecting the dignity, integrity and the worth of all persons, the overlap between the fields, including shared values, has received little attention. The purpose of this article is to describe the ways in which greater collaboration between the two fields can broaden their scope, enrich their scholarship, and better ground their practice...
June 2015: Bioethics
https://www.readbyqxmd.com/read/24758729/accuracy-and-acceptability-of-the-6-day-enlite-continuous-subcutaneous-glucose-sensor
#12
RANDOMIZED CONTROLLED TRIAL
Timothy S Bailey, Andrew Ahmann, Ronald Brazg, Mark Christiansen, Satish Garg, Elaine Watkins, John B Welsh, Scott W Lee
OBJECTIVE: This study evaluated the performance and acceptability of the Enlite(®) glucose sensor (Medtronic MiniMed, Inc., Northridge, CA). SUBJECTS AND METHODS: Ninety adults with type 1 or type 2 diabetes wore two Enlite sensors on the abdomen and/or buttock for 6 days and calibrated them at different frequencies. On Days 1, 3, and 6, accuracy was evaluated by comparison of sensor glucose values with frequently sampled plasma glucose values collected over a 12-h period...
May 2014: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/24405492/hypoglycemia-begets-hypoglycemia-the-order-effect-in-the-aspire-in-clinic-study
#13
RANDOMIZED CONTROLLED TRIAL
Satish K Garg, Ronald L Brazg, Timothy S Bailey, Bruce A Buckingham, Robert H Slover, David C Klonoff, John Shin, John B Welsh, Francine R Kaufman
BACKGROUND: The ASPIRE in-clinic study established that automatic suspension of insulin with the threshold suspend (TS) feature reduces the duration of induced hypoglycemia. The study's crossover design allowed the effects of antecedent hypoglycemia to be studied. SUBJECTS AND METHODS: The study enrolled 50 subjects who exercised until plasma glucose (YSI glucose and lactate analyzer; YSI, Inc., Yellow Springs, OH) reached ≤85 mg/dL. Hypoglycemia was evaluated after the YSI value reached <70 mg/dL...
March 2014: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/24311520/our-children-are-not-a-diagnosis-the-experience-of-parents-who-continue-their-pregnancy-after-a-prenatal-diagnosis-of-trisomy-13-or-18
#14
Jennifer Guon, Benjamin S Wilfond, Barbara Farlow, Tracy Brazg, Annie Janvier
Trisomy 13 and trisomy 18 (T13-18) are associated with high rates of perinatal death and with severe disability among survivors. Prenatal diagnosis (PND) may lead many women to terminate their pregnancy but some women choose to continue their pregnancy. We sent 503 invitations to answer a questionnaire to parents who belong to T13 and 18 internet support groups. Using mixed methods, we asked parents about their prenatal experience, their hopes, the life of their affected child, and their family experience. 332 parents answered questions about 272 children; 128 experienced PND...
February 2014: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/23650930/low-levels-of-circulating-alpha-1-antitrypsin-are-associated-with-spontaneous-abortions
#15
Tamar Madar, Galit Shahaf, Eyal Sheiner, Jared Brazg, Justin Levinson, Shimrit Yaniv Salem, Guy Twina, Joel Baron, Moshe Mazor, Gershon Holcberg, Eli C Lewis
OBJECTIVE: Alpha-1 antitrypsin (AAT), a circulating anti-inflammatory molecule, rises four- to sixfold during acute phase responses and during pregnancy. AAT deficiency is linked with various pregnancy complications. The aim of this study is to determine plasma concentrations and activity of AAT and serum cytokine levels in blood samples from women undergoing spontaneous abortions as compared with elective abortions. METHODS: A prospective case-control study consisted of patients with sporadic abortions (n = 15), recurrent spontaneous abortions (n = 14) and healthy pregnancies going through elective terminations (n = 11)...
December 2013: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/23537735/clinical-evaluation-of-the-freestyle-precision-pro-system
#16
Ronald Brazg, Kristen Hughes, Pamela Martin, Julie Coard, John Toffaletti, Elizabeth McDonnell, Elizabeth Taylor, Lausanne Farrell, Mona Patel, Jeanne Ward, Ting Chen, Shridhara Alva, Ronald Ng
BACKGROUND: A new version of international standard (ISO 15197) and CLSI Guideline (POCT12) with more stringent accuracy criteria are near publication. We evaluated the glucose test performance of the FreeStyle Precision Pro system, a new blood glucose monitoring system (BGMS) designed to enhance accuracy for point-of-care testing (POCT). METHODS: Precision, interference and system accuracy with 503 blood samples from capillary, venous and arterial sources were evaluated in a multicenter study...
June 5, 2013: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/23439171/variability-of-blood-glucose-meters-for-patient-self-testing-analysis-of-the-article-by-brazg-and-coauthors
#17
COMMENT
Andreas Pfützner
The article by Brzag and coauthors in this issue of Journal of Diabetes Science and Technology reports a competitive accuracy performance study for a branded meter in comparison with six low-cost meters currently available in the United States. It highlights several important topics: (1) the need for more stringent post-marketing requirements for blood glucose meters after launch and (2) low-cost meters use older technologies and their manufacturers do not usually seriously invest in new technology or constant quality assurance efforts...
2013: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/23439170/performance-variability-of-seven-commonly-used-self-monitoring-of-blood-glucose-systems-clinical-considerations-for-patients-and-providers
#18
Ronald L Brazg, Leslie J Klaff, Christopher G Parkin
BACKGROUND: Blood glucose data are frequently used in clinical decision making, thus it is critical that self-monitoring of blood glucose (SMBG) systems consistently provide accurate results. Concerns about SMBG accuracy have prompted the development of newly proposed International Organization for Standardization (ISO) standards: ≥ 95% of individual glucose results shall fall within ± 15 mg/dl of the results of the manufacturer's reference procedure at glucose concentrations <100 mg/dl and within ± 15% for values ≥ 100 mg/dl...
2013: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/22532433/informed-consent-for-whole-genome-sequencing-a-qualitative-analysis-of-participant-expectations-and-perceptions-of-risks-benefits-and-harms
#19
Holly K Tabor, Jacquie Stock, Tracy Brazg, Margaret J McMillin, Karin M Dent, Joon-Ho Yu, Jay Shendure, Michael J Bamshad
Scientific evidence on the extent to which ethical concerns about privacy, confidentiality, and return of results for whole genome sequencing (WGS) are effectively conveyed by informed consent (IC) is lacking. The aim of this study was to learn, via qualitative interviews, about participant expectations and perceptions of risks, benefits, and harms of WGS. Participants in two families with Miller syndrome consented for WGS were interviewed about their experiences of the IC process and their perceptions of risks, benefits, and harms of WGS...
June 2012: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/22316089/reduction-in-duration-of-hypoglycemia-by-automatic-suspension-of-insulin-delivery-the-in-clinic-aspire-study
#20
RANDOMIZED CONTROLLED TRIAL
Satish Garg, Ronald L Brazg, Timothy S Bailey, Bruce A Buckingham, Robert H Slover, David C Klonoff, John Shin, John B Welsh, Francine R Kaufman
BACKGROUND: The efficacy of automatic suspension of insulin delivery in induced hypoglycemia among subjects with type 1 diabetes was evaluated. SUBJECTS AND METHODS: In this randomized crossover study, subjects used a sensor-augmented insulin pump system with a low glucose suspend (LGS) feature that automatically stops insulin delivery for 2 h following a sensor glucose (SG) value ≤70 mg/dL. Subjects fasted overnight and exercised until their plasma glucose (measured with the YSI 2300 STAT Plus™ glucose and lactate analyzer [YSI Life Sciences, Yellow Springs, OH]) value reached ≤85 mg/dL on different occasions separated by washout periods lasting 3-10 days...
March 2012: Diabetes Technology & Therapeutics
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