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Parapertussis

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https://www.readbyqxmd.com/read/27886031/pertussis-in-north-central-and-northwestern-regions-of-algeria
#1
Nabila Benamrouche, Hassiba Tali Maamar, Malika Lazri, Sonia Hasnaoui, Abdelkarim Radoui, Ourida Lafer, Rachida Boukari, Chawki Kaddache, Zakia Arrada, Kheira Rahal
INTRODUCTION: Pertussis outbreaks continue to occur in many countries despite high vaccination coverage. Under-diagnosed cases in adolescents and adults may result in increased transmission to infants, who are at risk of severe pertussis. Additional measures to protect both groups should be considered. METHODOLOGY: Nasopharyngeal samples and sera were collected from patients and household contacts with clinically suspected pertussis. Diagnoses were confirmed by culture, real-time polymerase chain reaction (PCR), and serology...
November 24, 2016: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/27783449/essential-role-of-bordetella-nadc-in-a-quinolinate-salvage-pathway-for-nad-biosynthesis
#2
Timothy J Brickman, Ryan J Suhadolc, Pamela J McKelvey, Sandra K Armstrong
NAD is produced via de novo biosynthesis pathways and by salvage or recycling routes. The classical Bordetella bacterial species are known to be auxotrophic for nicotinamide or nicotinic acid. This study confirmed that Bordetella bronchiseptica, Bordetella pertussis, and Bordetella parapertussis have the recycling/salvage pathway genes pncA and pncB, for use of nicotinamide or nicotinic acid, respectively, for NAD synthesis. Although these Bordetellae lack the nadA and nadB genes needed for de novo NAD biosynthesis, remarkably, they have one de novo pathway gene, nadC, encoding quinolinate phosphoribosyltransferase...
October 26, 2016: Molecular Microbiology
https://www.readbyqxmd.com/read/27716057/acquisition-and-loss-of-virulence-associated-factors-during-genome-evolution-and-speciation-in-three-clades-of-bordetella-species
#3
Bodo Linz, Yury V Ivanov, Andrew Preston, Lauren Brinkac, Julian Parkhill, Maria Kim, Simon R Harris, Laura L Goodfield, Norman K Fry, Andrew R Gorringe, Tracy L Nicholson, Karen B Register, Liliana Losada, Eric T Harvill
BACKGROUND: The genus Bordetella consists of nine species that include important respiratory pathogens such as the 'classical' species B. bronchiseptica, B. pertussis and B. parapertussis and six more distantly related and less extensively studied species. Here we analyze sequence diversity and gene content of 128 genome sequences from all nine species with focus on the evolution of virulence-associated factors. RESULTS: Both genome-wide sequence-based and gene content-based phylogenetic trees divide the genus into three species clades...
September 30, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27575466/periodic-solutions-in-an-sirws-model-with-immune-boosting-and-cross-immunity
#4
Tiffany Leung, Barry D Hughes, Federico Frascoli, James M McCaw
Incidence of whooping cough, an infection caused by Bordetella pertussis and Bordetella parapertussis, has been on the rise since the 1980s in many countries. Immunological interactions, such as immune boosting and cross-immunity between pathogens, have been hypothesised to be important drivers of epidemiological dynamics. We present a two-pathogen model of transmission which examines how immune boosting and cross-immunity can influence the timing and severity of epidemics. We use a combination of numerical simulations and bifurcation techniques to study the dynamical properties of the system, particularly the conditions under which stable periodic solutions are present...
August 27, 2016: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/27530444/increase-in-pertussis-cases-along-with-high-prevalence-of-two-emerging-genotypes-of-bordetella-pertussis-in-per%C3%A3%C2%BA-2012
#5
H Bailon, N León-Janampa, C Padilla, D Hozbor
BACKGROUND: As has occurred in many regions worldwide, in 2012 the incidence of pertussis increased in Perú. This epidemiologic situation has been associated with a waning vaccine-induced immunity and the adaptation of Bordetella pertussis to vaccine-induced immunity along with improved diagnostic methods. METHODS: The study comprised a total of 840 pertussis-suspected cases reported in Perú during 2012. We summarize here the distribution of pertussis cases according to age and immunization status along with the immunization-coverage rate...
2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27515393/development-of-vaccines-against-pertussis-caused-by-bordetella-holmesii-using-a-mouse-intranasal-challenge-model
#6
Momoko Saito, Keita Odanaka, Nao Otsuka, Kazunari Kamachi, Mineo Watanabe
Bordetella holmesii is recognized as the third causative agent of pertussis (whooping cough) in addition to Bordetella pertussis and Bordetella parapertussis. Pertussis caused by B. holmesii is not rare around the world. However, to date, there is no effective vaccine against B. holmesii. We examined the protective potency of pertussis vaccines available in Japan and vaccines prepared from B. holmesii. A murine model of respiratory infection was exploited to evaluate protective potency. No Japanese commercial pertussis vaccines were effective against B...
September 2016: Microbiology and Immunology
https://www.readbyqxmd.com/read/27487509/occurence-of-bordetella-bronchiseptica-in-domestic-cats-with-upper-respiratory-tract-infections
#7
M Garbal, Ł Adaszek, P Łyp, J Frymus, M Winiarczyk, S Winiarczyk
Bordetella bronchiseptica is a widespread Gram-negative pathogen occurring in different mammal species. It is known to play a role in the etiology of infectious atrophic rhinitis of swine, canine kennel cough, respiratory syndromes of cats, rabbits and guinea pigs, and sporadic human cases have also been reported. The aim of this article is to present the occurrence of infections caused by these bacteria in domestic cats with respiratory symptoms, as well as to conduct a molecular analysis of the flaA gene B...
2016: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/27391699/two-distinct-episodes-of-whooping-cough-caused-by-consecutive-bordetella-pertussis-and-bordetella-parapertussis-infections-in-a-fully-immunized-healthy-boy
#8
Ulrich Heininger, Detlef Schlassa
We describe a 5-year-old, fully immunized boy with PCR proven consecutive B. pertussis and B. parapertussis infections causing typical whooping cough at the age of 2 and 5 years, respectively. Neither pertussis immunization nor disease provides reliable immunity against further episodes of whooping cough.
July 6, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27337481/bordetella-pertussis
#9
Delma J Nieves, Ulrich Heininger
Pertussis is a highly infectious vaccine-preventable cough illness that continues to be a significant source of morbidity and mortality around the world. The majority of human illness is caused by Bordetella pertussis, and some is caused by Bordetella parapertussis. Bordetella is a Gram-negative, pleomorphic, aerobic coccobacillus. In the past several years, even countries with high immunization rates in early childhood have experienced rises in pertussis cases. Reasons for the resurgence of reported pertussis may include molecular changes in the organism and increased awareness and diagnostic capabilities, as well as lessened vaccine efficacy and waning immunity...
June 2016: Microbiology Spectrum
https://www.readbyqxmd.com/read/27224518/surveillance-of-pertussis-methods-and-implementation
#10
Nicole Guiso, Carl Heinz Wirsing von König
INTRODUCTION: Pertussis or whooping cough is a respiratory disease caused by Bordetella pertussis or, to a lesser extent, by B. parapertussis. Vaccines against pertussis have been widely used for more than 50 years and have led to a significant reduction of morbidity and mortality. However, even in countries with a high vaccine coverage, the disease is still not well controlled. Surveillance is urgently needed. AREAS COVERED: This review summarizes surveillance methods and gives examples that may be used when setting up a surveillance program or analyzing an outbreak...
July 2016: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/27166543/shattering-a-myth-whooping-cough-susceptible-to-antibiotics
#11
Muhammad Ali Syed, Bushra Jamil, Habib Bokhari
Bordetella parapertussis is the causative agent of a milder form of pertussis or whooping cough. Little is reported about the antibiotic resistance patterns and mechanism of drug resistance of Bordetella parapertussis. The objective of this study has been to investigate antimicrobial resistance, distribution of integrons and presence of gene cassettes to quinolones (qnr) and sulfonamides (sul) among B. parapertussis strains' isolated from Pakistan. Thirty-five (35) samples were collected from various hospitals of Pakistan from children (median age 3 years) with pertussis-like symptoms, all were tested and confirmed to be B...
May 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27121506/comparison-of-molecular-detection-methods-for-pertussis-in-children-during-a-state-wide-outbreak
#12
X Qin, D M Zerr, M P Kronman, A L Adler, J E Berry, S Rich, A M Buccat, M Xu, J A Englund
A state-wide pertussis outbreak occurred in Washington during the winter-spring months of 2012, concurrent with respiratory viral season. We compared performance characteristics of a laboratory-developed pertussis PCR (LD-PCR for Bordetella pertussis, Bordetella parapertussis, and Bordetella holmesii) and rapid multiplex PCR (RM-PCR) for respiratory viruses (FilmArray™, BioFire, B. pertussis data unblinded following FDA approval post outbreak). We analyzed three cohorts of patients using physician testing orders as a proxy for clinical suspicion for pertussis or respiratory viruses: Cohort 1, tested by LD-PCR for pertussis pathogens only by nasopharyngeal swab; Cohort 2, by RM-PCR for respiratory viruses only by mid-nasal turbinate swab; and Cohort 3, by both methods...
2016: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/27076914/laboratory-based-surveillance-of-pertussis-using-multitarget-real-time-pcr-in-japan-evidence-for-bordetella-pertussis-infection-in-preteens-and-teens
#13
K Kamachi, S Yoshino, C Katsukawa, N Otsuka, Y Hiramatsu, K Shibayama
Between January 2013 and December 2014, we conducted laboratory-based surveillance of pertussis using multitarget real-time PCR, which discriminates among Bordetella pertussis, Bordetella parapertussis, Bordetella holmesii and Mycoplasma pneumoniae. Of 355 patients clinically diagnosed with pertussis in Japan, B. pertussis, B. parapertussis and M. pneumoniae were detected in 26% (n = 94), 1.1% (n = 4) and 0.6% (n = 2), respectively, whereas B. holmesii was not detected. It was confirmed that B. parapertussis and M...
November 2015: New Microbes and New Infections
https://www.readbyqxmd.com/read/26967813/incidence-and-diagnosis-of-pertussis-in-south-african-children-hospitalized-with-lower-respiratory-tract-infection
#14
Rudzani Muloiwa, Felix S Dube, Mark P Nicol, Heather J Zar, Gregory D Hussey
BACKGROUND: The incidence of pertussis in children in low- and middle-income countries is poorly described. This study aimed to prospectively investigate the incidence of pertussis in South African children hospitalized with lower respiratory tract infection (LRTI). METHODS: Children hospitalized with LRTI in Cape Town, South Africa were enrolled over 1 year. Clinical data were collected. A nasopharyngeal (NP) swab and induced sputum (IS) were taken, and polymerase chain reaction specific for Bordetella pertussis (IS481+/hIS1001-) and Bordetella parapertussis (IS1001+) was performed...
June 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/26837155/-pertussis-whooping-cough-an-update
#15
Ingo Stock
Whooping cough is a highly contagious respiratory disease which is caused predominantly by the gram-negative bacterium Bordetella pertussis. Further Bordetella species such as B. parapertussis and the recently discovered species B. holmesii are also involved in whooping cough-like diseases. Depending on age, vaccination status and distance to pre-infection with B. pertussis, whooping cough shows a wide range of symptoms. The disease occurs at any age, leaving only short time immunity. During the last 15 years, in industrialized countries the number of reported pertussis cases has been increased markedly...
December 2015: Medizinische Monatsschrift Für Pharmazeuten
https://www.readbyqxmd.com/read/26459829/diversity-of-secretion-systems-associated-with-virulence-characteristics-of-the-classical-bordetellae
#16
Jihye Park, Ying Zhang, Chun Chen, Edward G Dudley, Eric T Harvill
Secretion systems are key virulence factors, modulating interactions between pathogens and the host's immune response. Six potential secretion systems (types 1-6; T1SS-T6SS) have been discussed in classical bordetellae, respiratory commensals/pathogens of mammals. The prototypical Bordetella bronchiseptica strain RB50 genome seems to contain all six systems, whilst two human-restricted subspecies, Bordetella parapertussis and Bordetella pertussis, have lost different subsets of these. This implicates secretion systems in the divergent evolutionary histories that have led to their success in different niches...
December 2015: Microbiology
https://www.readbyqxmd.com/read/26388594/pertussis-in-children-in-the-%C3%A4-stanbul-faculty-of-medicine-results-for-four-years
#17
Lütfiye Öksüz, Selda Hançerli, Ayper Somer, Nuran Salman, Nezahat Gürler
We investigated the frequency of pertussis among children in the İstanbul Faculty of Medicine Hospital during a period of four years. Clinical specimens were obtained from children who exhibited symptoms of whooping cough; a portion of the cases were confirmed microbiologically by PCR as pertussis. A total of 410 nasopharyngeal aspirates were taken for detection of Bordetella pertussis/parapertussis. The age groups of the patients were 0-4 months (n=201), >4 -12 months (n=49), 1-4 years (n=79), 5-9 years (n=46), 10-14 years (n=27) and >15 years (n=8)...
November 2014: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/26247360/the-bordetella-secreted-regulator-bspr-is-translocated-into-the-nucleus-of-host-cells-via-its-n-terminal-moiety-evaluation-of-bacterial-effector-translocation-by-the-escherichia-coli-type-iii-secretion-system
#18
Akio Abe, Ryutaro Nishimura, Naomichi Tanaka, Jun Kurushima, Asaomi Kuwae
Bordetella bronchiseptica is genetically related to B. pertussis and B. parapertussis, which cause respiratory tract infections in humans. These pathogens possess a large number of virulence factors, including the type III secretion system (T3SS), which is required for the delivery of effectors into the host cells. In a previous study, we identified a transcriptional regulator, BspR, that is involved in the regulation of the T3SS-related genes in response to iron-starved conditions. A unique feature of BspR is that this regulator is secreted into the extracellular milieu via the T3SS...
2015: PloS One
https://www.readbyqxmd.com/read/26242280/bordetella-pertussis-b-parapertussis-vaccines-and-cycles-of-whooping-cough
#19
REVIEW
Valérie Bouchez, Nicole Guiso
Whooping cough is a vaccine-preventable disease due to Bordetella pertussis and B. parapertussis. This highly contagious respiratory disease occurs through epidemic cycles every 3-5 years and vaccination did not change this frequency. Models suggest that the cyclic increase of susceptibles is linked to demographic differences and different vaccine coverage. However, differences in surveillance of the disease as well as adaptation of the agents of the disease to their human hosts and to vaccine pressure might also play an important role...
October 2015: Pathogens and Disease
https://www.readbyqxmd.com/read/26164553/structure-activity-characterization-of-bordetella-petrii-lipid-a-from-environment-to-human-isolates
#20
Soorej M Basheer, Valerie Bouchez, Alexey Novikov, Luis A Augusto, Nicole Guiso, Martine Caroff
Bordetella petrii, a facultative anaerobic species, is the only known member of the Bordetella genus with environmental origin. However it was also recently isolated from humans. The structures of the B. petrii lipid A moieties of the endotoxins were characterized here for the first time for an environmental strain and compared to that of human isolates. Characterization was achieved using chemical analyses, gas chromatography-mass spectrometry, and Matrix Assisted Laser Desorption Ionisation mass spectrometry...
January 2016: Biochimie
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