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https://www.readbyqxmd.com/read/28906022/identification-and-characterization-of-a-brilliant-yellow-pigment-produced-by-bordetella-pertussis
#1
Keita Odanaka, Masato Iwatsuki, Tomomitsu Satho, Mineo Watanabe
Culture supernatant of Bordetella pertussis has a brilliant yellow color; however, the structure and biological role of the pigment have not been investigated. We extracted the brilliant yellow-colored fraction from the culture supernatant of B. pertussis and analyzed it by HPLC. UV-visible spectral analysis and mass spectrometry identified the brilliant yellow pigment as riboflavin. Riboflavin production was high in lag and early log phases and riboflavin enhanced the growth of B. pertussis in low-density cultures...
September 14, 2017: Microbiology and Immunology
https://www.readbyqxmd.com/read/28892012/bordetella-adenylate-cyclase-hemolysin-toxins
#2
REVIEW
Nicole Guiso
Adenylate cyclase-hemolysin toxin is secreted and produced by three classical species of the genus Bordetella: Bordetella pertussis, B. parapertussis and B. bronchiseptica. This toxin has several properties such as: (i) adenylate cyclase activity, enhanced after interaction with the eukaryotic protein, calmodulin; (ii) a pore-forming activity; (iii) an invasive activity. It plays an important role in the pathogenesis of these Bordetella species responsible for whooping cough in humans or persistent respiratory infections in mammals, by modulating host immune responses...
September 11, 2017: Toxins
https://www.readbyqxmd.com/read/28857261/a-recombinant-iron-transport-protein-from-bordetella-pertussis-confers-protection-against-bordetella-parapertussis
#3
Jimena Alvarez Hayes, Juan Marcos Oviedo, Hugo Valdez, Juan Martín Laborde, Fabricio Maschi, Miguel Ayala, Rohan Shah, Marcelo Fernandez Lahore, Maria Eugenia Rodriguez
Whooping cough is a reemerging disease caused by Bordetella parapertussis and B. parapertussis. New protective antigens are needed to improve the efficacy of current vaccines against both species. Using proteomic tools we here found that B. parapertussis expresses a homolog of AfuA, a previously reported new vaccine candidate against B. pertussis. We found that this homolog, named as AfuABpp , is expressed during B. parapertussis infection, exposed on the surface of the bacteria and recognized by specific antibodies induced by the recombinant AfuA cloned from B...
August 31, 2017: Microbiology and Immunology
https://www.readbyqxmd.com/read/28827216/activation-of-bvg-repressed-genes-in-bordetella-pertussis-by-risa-requires-cross-talk-from-a-non-co-operonic-histidine-kinase-risk
#4
Qing Chen, Victoria Ng, Jason M Warfel, Tod J Merkel, Scott Stibitz
The two-component response regulator RisA, encoded by BP3554 in the Bordetella pertussis Tohama I genomic sequence, is a known activator of vrgs, a set of genes whose expression is increased under the same environmental conditions (known as modulation) that result in repression of the bvgAS virulence regulon. Here we demonstrate that RisA is phosphorylated in vivo and that RisA phosphorylation is required for activation of vrgs. An adjacent histidine kinase gene, risS, is truncated by frameshift mutation in B...
August 21, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28707065/nasopharyngeal-pertussis-toxin-iga-antibodies-in-the-diagnosis-of-pertussis-in-australian-community-patients
#5
D Norman, M Karimi, A Herbert, M H Beaman
Nasopharyngeal aspirate (NPA) Bordetella pertussis-specific IgA antibody assay using whole-cell (WC) antigen has previously been shown to have promise in the diagnosis of patients with suspected pertussis. Recently, the use of WC assays in serum have been replaced by pertussis toxin (PT) because of specificity concerns. In this study, PT and WC B. pertussis-specific IgA antibody was assayed in 491 NPAs. Specimens also had molecular testing for the presence of B. pertussis and B. parapertussis as per the usual laboratory protocol...
July 13, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28701222/how-well-do-icd-9-physician-claim-diagnostic-codes-identify-confirmed-pertussis-cases-in-alberta-canada-a-canadian-immunization-research-network-cirn-study
#6
Sumana Fathima, Kimberley A Simmonds, Steven J Drews, Lawrence W Svenson, Jeffrey C Kwong, Salaheddin M Mahmud, Susan Quach, Caitlin Johnson, Kevin L Schwartz, Natasha S Crowcroft, Margaret L Russell
BACKGROUND: Rates of Bordetella pertussis have been increasing in Alberta, Canada despite vaccination programs. Waning immunity from existing acellular component vaccines may be contributing to this. Vaccine effectiveness can be estimated using a variety of data sources including diagnostic codes from physician billing claims, public health records, reportable disease and laboratory databases. We sought to determine if diagnostic codes from billing claims (administrative data) are adequately sensitive and specific to identify pertussis cases among patients who had undergone disease-specific laboratory testing...
July 12, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28700751/a-high-seroprevalence-of-antibodies-to-pertussis-toxin-among-japanese-adults-qualitative-and-quantitative-analyses
#7
Takumi Moriuchi, Nao Otsuka, Yukihiro Hiramatsu, Keigo Shibayama, Kazunari Kamachi
In 2013, national serosurveillance detected a high seroprevalence of antibodies to pertussis toxin (PT) from Bordetella pertussis among Japanese adults. Thus, we aimed to determine the cause(s) of this high seroprevalence, and analyzed the titers of antibodies to PT and filamentous hemagglutinin (FHA) among adults (35-44 years old), young children (4-7 years old), and older children (10-14 years old). Our quantitative analyses revealed that adults had higher seroprevalences of anti-PT IgG and PT-neutralizing antibodies, and similar titers of anti-FHA IgG, compared to the young and older children...
2017: PloS One
https://www.readbyqxmd.com/read/28538850/-infection-by-bordetella-pertussis-and-bordetella-parapertussis-in-cases-of-suspected-whooping-cough-2011-2015-in-mar-del-plata-argentina
#8
Silvina Lavayén, Claudia Zotta, Marcela Cepeda, Claudia Lara, Analia Rearte, Mabel Regueira
Objectives: . To classify the study population in the Argentinian National Health Surveillance System framework, determine the proportion of infection by Bordetella pertussis and Bordetella parapertussis, and identify factors associated with the cases of suspected whooping cough attended to in the city of Mar del Plata and its outskirts during the period 2011- 2015. Materials and Methods: An observational and descriptive study was carried out. Clinical cases with suspicion of whooping cough were diagnosed by laboratory...
January 2017: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/28524084/bordetella-holmesii-lipid-a-structures-and-corresponding-genomic-sequences-comparison-in-three-clinical-isolates-and-the-reference-strain-atcc-51541
#9
Valérie Bouchez, Sami AlBitar-Nehmé, Alexey Novikov, Nicole Guiso, Martine Caroff
Bordetella holmesii can cause invasive infections but can also be isolated from the respiratory tract of patients with whooping-cough like symptoms. For the first time, we describe the lipid A structure of B. holmesii reference strain ATCC 51541 (alias NCTC12912 or CIP104394) and those of three French B. holmesii clinical isolates originating from blood (Bho1) or from respiratory samples (FR4020 and FR4101). They were investigated using chemical analyses, gas chromatography-mass spectrometry (GC-MS), and matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS)...
May 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28514288/bordetella-parapertussis-outbreak-in-southeastern-minnesota-and-the-united-states-2014
#10
Vytas P Karalius, Stefanea L Rucinski, Jayawant N Mandrekar, Robin Patel
Whooping cough is traditionally ascribed to Bordetella pertussis; however, Bordetella parapertussis can cause a similar clinical syndrome. This study describes an outbreak of B. parapertussis in Southeastern Minnesota and the United States (US) in 2014. This was a retrospective analysis of Mayo Clinic and Mayo Medical Laboratories patients who tested positive for B. parapertussis from 2012 to 2014. The medical records of Mayo Clinic patients who tested positive in 2014 were reviewed for demographic information, presenting symptoms, disease course, and vaccination history...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28511667/epidemiology-of-pertussis-in-casablanca-morocco-contribution-of-conventional-and-molecular-diagnosis-tools
#11
Khalid Katfy, Nicole Guiso, Idrissa Diawara, Khalid Zerouali, Bouchra Slaoui, Zineb Jouhadi, Abdelhadi Zineddine, Houria Belabbes, Naima Elmdaghri
BACKGROUND: Pertussis, a vaccine preventable disease, is still responsible of significant morbidity and mortality around the world, mostly in newborns. The aim of the present study was (1) to introduce pertussis surveillance in the major pediatric hospital of Casablanca (2) to analyze the prevalence of pertussis among children under 14 years of age and their entourage in Casablanca, Morocco. METHODS: This is a prospective and non-case controlled study, including children suspected of Pertussis admitted at the Abderrahim Harouchi Pediatric Hospital in Casablanca, from January 2013 to June 2015...
May 16, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28403204/improving-specificity-of-bordetella-pertussis-detection-using-a-four-target-real-time-pcr
#12
Helena Martini, Liselot Detemmerman, Oriane Soetens, Erlangga Yusuf, Denis Piérard
The incidence of whooping cough, a contagious respiratory disease caused by Bordetella pertussis, is on the rise despite existing vaccination programmes. Similar, though usually milder, respiratory symptoms may be caused by other members of the Bordetella genus: B. parapertussis, B. holmesii, and B. bronchiseptica. Pertussis diagnosis is mostly done using PCR, but the use of multiple targets is necessary in order to differentiate the different Bordetella spp. with sufficient sensitivity and specificity. In this study we evaluate a multiplex PCR assay for the differentiation of B...
2017: PloS One
https://www.readbyqxmd.com/read/28369240/do-pertussis-vaccines-protect-against-bordetella-parapertussis
#13
Juventila Liko, Steve G Robison, Paul R Cieslak
We calculated the effectiveness of pertussis vaccine in preventing parapertussis among Oregon children 2 months to 10 years of age using 2 methods. During 2011-2016, the 2 VE methods found 66% (95% CI, 59-75%) and 82% (95% CI, 69-90%) effectiveness against parapertussis. Pertussis vaccine may induce cross-immunity.
June 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28283011/-investigation-of-seropositivity-of-bordetella-pertussis-in-adults-in-a-university-hospital
#14
Lütfiye Öksüz, Nezahat Gürler, Ali Ağaçfidan
Whooping cough is a vaccine-preventable infectious diseases caused by Bordetella pertussis/parapertussis. Despite of routine immunization programs in the world, pertussis still remains endemic. Recently unvaccinated or partially immunized infants have infected with this pathogen and also increase of incidence was observed in adolescents and adults. The source of pertussis in newborns are attributed to household, especially due to the family members. Theaim of this study was to determine B.pertussis IgG antibody positivity by ELISA method in adults...
January 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28177609/fine-epitope-mapping-of-two-antibodies-neutralizing-the-bordetella-adenylate-cyclase-toxin
#15
Xianzhe Wang, James A Stapleton, Justin R Klesmith, Erik L Hewlett, Timothy A Whitehead, Jennifer A Maynard
Adenylate cyclase toxin (ACT) is an important Bordetella pertussis virulence factor that is not included in current acellular pertussis vaccines. We previously demonstrated that immunization with the repeat-in-toxin (RTX) domain of ACT elicits neutralizing antibodies in mice and discovered the first two antibodies to neutralize ACT activities by occluding the receptor-binding site. Here, we fully characterize these antibodies and their epitopes. Both antibodies bind ACT with low nanomolar affinity and cross-react with ACT homologues produced by B...
March 7, 2017: Biochemistry
https://www.readbyqxmd.com/read/28095485/bordetella-parapertussis-circumvents-neutrophil-extracellular-bactericidal-mechanisms
#16
Juan Gorgojo, Emilia Scharrig, Ricardo M Gómez, Eric T Harvill, Maria Eugenia Rodríguez
B. parapertussis is a whooping cough etiological agent with the ability to evade the immune response induced by pertussis vaccines. We previously demonstrated that in the absence of opsonic antibodies B. parapertussis hampers phagocytosis by neutrophils and macrophages and, when phagocytosed, blocks intracellular killing by interfering with phagolysosomal fusion. But neutrophils can kill and/or immobilize extracellular bacteria through non-phagocytic mechanisms such as degranulation and neutrophil extracellular traps (NETs)...
2017: PloS One
https://www.readbyqxmd.com/read/27886031/pertussis-in-north-central-and-northwestern-regions-of-algeria
#17
Nabila Benamrouche, Hassiba Tali Maamar, Malika Lazri, Sonia Hasnaoui, Abdelkarim Radoui, Ourida Lafer, Rachida Boukari, Chawki Kaddache, Zakia Arrada, Kheira Rahal
INTRODUCTION: Pertussis outbreaks continue to occur in many countries despite high vaccination coverage. Under-diagnosed cases in adolescents and adults may result in increased transmission to infants, who are at risk of severe pertussis. Additional measures to protect both groups should be considered. METHODOLOGY: Nasopharyngeal samples and sera were collected from patients and household contacts with clinically suspected pertussis. Diagnoses were confirmed by culture, real-time polymerase chain reaction (PCR), and serology...
November 24, 2016: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/27783449/essential-role-of-bordetella-nadc-in-a-quinolinate-salvage-pathway-for-nad-biosynthesis
#18
Timothy J Brickman, Ryan J Suhadolc, Pamela J McKelvey, Sandra K Armstrong
Nicotinamide adenine dinucleotide (NAD) is produced via de novo biosynthesis pathways and by salvage or recycling routes. The classical Bordetella bacterial species are known to be auxotrophic for nicotinamide or nicotinic acid. This study confirmed that Bordetella bronchiseptica, Bordetella pertussis and Bordetella parapertussis have the recycling/salvage pathway genes pncA and pncB, for use of nicotinamide or nicotinic acid, respectively, for NAD synthesis. Although these Bordetellae lack the nadA and nadB genes needed for de novo NAD biosynthesis, remarkably, they have one de novo pathway gene, nadC, encoding quinolinate phosphoribosyltransferase...
October 26, 2016: Molecular Microbiology
https://www.readbyqxmd.com/read/27716057/acquisition-and-loss-of-virulence-associated-factors-during-genome-evolution-and-speciation-in-three-clades-of-bordetella-species
#19
Bodo Linz, Yury V Ivanov, Andrew Preston, Lauren Brinkac, Julian Parkhill, Maria Kim, Simon R Harris, Laura L Goodfield, Norman K Fry, Andrew R Gorringe, Tracy L Nicholson, Karen B Register, Liliana Losada, Eric T Harvill
BACKGROUND: The genus Bordetella consists of nine species that include important respiratory pathogens such as the 'classical' species B. bronchiseptica, B. pertussis and B. parapertussis and six more distantly related and less extensively studied species. Here we analyze sequence diversity and gene content of 128 genome sequences from all nine species with focus on the evolution of virulence-associated factors. RESULTS: Both genome-wide sequence-based and gene content-based phylogenetic trees divide the genus into three species clades...
September 30, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27575466/periodic-solutions-in-an-sirws-model-with-immune-boosting-and-cross-immunity
#20
Tiffany Leung, Barry D Hughes, Federico Frascoli, James M McCaw
Incidence of whooping cough, an infection caused by Bordetella pertussis and Bordetella parapertussis, has been on the rise since the 1980s in many countries. Immunological interactions, such as immune boosting and cross-immunity between pathogens, have been hypothesised to be important drivers of epidemiological dynamics. We present a two-pathogen model of transmission which examines how immune boosting and cross-immunity can influence the timing and severity of epidemics. We use a combination of numerical simulations and bifurcation techniques to study the dynamical properties of the system, particularly the conditions under which stable periodic solutions are present...
December 7, 2016: Journal of Theoretical Biology
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