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https://www.readbyqxmd.com/read/29244272/comparison-of-perioperative-outcomes-with-or-without-renorrhaphy-during-open-partial-nephrectomy-a-propensity-score-matched-analysis
#1
Hidekazu Tachibana, Toshio Takagi, Tsunenori Kondo, Hideki Ishida, Kazunari Tanabe
PURPOSE: Renorrhaphy in partial nephrectomy may damage intraparenchymal vessels and compress the renal parenchyma, which may lead to the formation of renal artery pseudoaneurysms or vascularized parenchymal volume reduction. Using propensity score matching, we compared surgical outcomes following non-renorrhaphy and renorrhaphy techniques for open partial nephrectomy (OPN) for T1a renal tumors. MATERIALS AND METHODS: We retrospectively analyzed data from 159 patients with normal contralateral kidneys who underwent OPN for T1a renal tumors and pre- and postoperative enhanced computed tomography between 2012 and 2015...
December 18, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29243981/assessment-of-intracranial-venous-blood-flow-after-subarachnoid-hemorrhage-a-new-approach-to-diagnose-vasospasm-with-transcranial-color-coded-duplex-sonography
#2
Florian Connolly, Stephan J Schreiber, Christoph Leithner, Georg Bohner, Peter Vajkoczy, José M Valdueza
OBJECTIVE Transcranial color-coded duplex sonography (TCCS) is a reliable tool that is used to assess vasospasm in the M1 segment of the middle cerebral artery (MCA) after subarachnoid hemorrhage (SAH). A distinct increase in blood flow velocity (BFV) is the principal criterion for vasospasm. The MCA/internal carotid artery (ICA) index (Lindegaard Index) is also widely used to distinguish between vasospasm and cerebral hyperperfusion. However, extracranial ultrasonography assessment of the neck vessels might be difficult in an intensive care unit...
December 15, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29242099/downregulation-of-circulating-mots-c-levels-in-patients-with-coronary-endothelial-dysfunction
#3
Qing Qin, Silvia Delrio, Junxiang Wan, R Jay Widmer, Pinchas Cohen, Lilach O Lerman, Amir Lerman
BACKGROUND: MOTS-c is one of the newly identified mitochondrial-derived peptides which play a role in regulating metabolic homeostasis. The current study aimed to investigate whether circulating MOTS-c levels are also associated with endothelial dysfunction(ED) in patients without significant structural coronary lesions. METHODS: Forty patients undergoing coronary angiography and endothelial function testing for clinical indications of recurrent angina with no structural coronary lesions were included in the study...
December 6, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29238303/near-wall-migration-dynamics-of-erythrocytes-in-vivo-effects-of-cell-deformability-and-arteriolar-bifurcation
#4
Bumseok Namgung, Yan Cheng Ng, Hwa Liang Leo, Joseph M Rifkind, Sangho Kim
Red blood cell (RBC) deformability has a significant impact on microcirculation by affecting cell dynamics. Despite previous studies that have demonstrated the margination of rigid cells and particles in vitro, little information is available on the in vivo margination of deformability-impaired RBCs under physiological flow and hematocrit conditions. Thus, in this study, we examined how the deformability-dependent, RBC migration alters the cell distribution under physiological conditions, particularly in arteriolar network flows...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29237910/clinical-significance-of-twist-e-cadherin-and-n-cadherin-protein-expression-in-endometrioid-adenocarcinoma
#5
Xinping Xie, Xiu Zheng, Jinhua Wang, Lihong Chen
OBJECTIVE: The aim of the study was to investigate the expression of Twist, E-cadherin, and N-cadherin both in normal endometrium and in endometrioid adenocarcinoma tissues (NET and EAT), and further discuss the relationship between the proteins expression and the clinical parameters. METHODS: Seventy-six EAT and 50 NET were collected from endometrioid adenocarcinoma patients and patients who received hysterectomy. We used immunohistochemistry (two steps methods) to detect the expression of Twist, E-cadherin, and N-cadherin proteins in EAT and NET...
2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29237853/the-behavioural-response-of-migrating-humpback-whales-to-a-full-seismic-airgun-array
#6
Rebecca A Dunlop, Michael J Noad, Robert D McCauley, Eric Kniest, Robert Slade, David Paton, Douglas H Cato
Despite concerns on the effects of noise from seismic survey airguns on marine organisms, there remains uncertainty as to the biological significance of any response. This study quantifies and interprets the response of migrating humpback whales (Megaptera novaeangliae) to a 3130 in3 (51.3l) commercial airgun array. We compare the behavioural responses to active trials (array operational; n = 34 whale groups), with responses to control trials (source vessel towing the array while silent; n = 33) and baseline studies of normal behaviour in the absence of the vessel (n = 85)...
December 20, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29237738/ascending-vasa-recta-are-angiopoietin-tie2-dependent-lymphatic-like-vessels
#7
Yael Kenig-Kozlovsky, Rizaldy P Scott, Tuncer Onay, Isabel Anna Carota, Benjamin R Thomson, Hyea Jin Gil, Veronica Ramirez, Shinji Yamaguchi, Christine E Tanna, Stefan Heinen, Christine Wu, Radu V Stan, Janet D Klein, Jeff M Sands, Guillermo Oliver, Susan E Quaggin
Urinary concentrating ability is central to mammalian water balance and depends on a medullary osmotic gradient generated by a countercurrent multiplication mechanism. Medullary hyperosmolarity is protected from washout by countercurrent exchange and efficient removal of interstitial fluid resorbed from the loop of Henle and collecting ducts. In most tissues, lymphatic vessels drain excess interstitial fluid back to the venous circulation. However, the renal medulla is devoid of classic lymphatics. Studies have suggested that the fenestrated ascending vasa recta (AVRs) drain the interstitial fluid in this location, but this function has not been conclusively shown...
December 13, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29236987/extra-gonadal-actions-of-fsh-a-critical-need-for-novel-genetic-models
#8
T Rajendra Kumar
Follicle-stimulating hormone (FSH) is critical for ovarian folliculogenesis and essential for female fertility. FSH binds to FSH receptors (FSHRs) and regulates estrogen production in ovarian granulosa cells to orchestrate female reproductive physiology. Ovarian senescence that occurs as a function of aging results in loss of estrogen production and this is believed to be the major reason for bone loss in postmenopausal women. Although conflicting, studies in rodents and humans during the last decade provide genetic, pharmacological and physiological evidence that elevated FSH levels that occur in the face of normal or declining estrogen levels directly regulate bone mass and adiposity...
December 11, 2017: Endocrinology
https://www.readbyqxmd.com/read/29233846/ve-cadherin-mediated-epigenetic-regulation-of-endothelial-gene-expression
#9
Marco F Morini, Costanza Giampietro, Monica Corada, Federica Pisati, Elisa Lavarone, Sara I Cunha, Lei L Conze, Nicola J O'Reilly, Dhira Joshi, Svend Kjaer, Roger George, Emma Nye, Anqi Ma, Jian Jin, Richard Mitter, Michela Lupia, Ugo Cavallaro, Diego Pasini, Dinis P Calado, Elisabetta Dejana, Andrea Taddei
Rationale: The mechanistic foundation of vascular maturation is still largely unknown. Several human pathologies are characterized by deregulated angiogenesis and unstable blood vessels. Solid tumours, for instance, get their nourishment from newly formed structurally abnormal vessels which present wide and irregular inter-endothelial junctions. Expression and clustering of the main endothelial-specific adherens junction protein, vascular endothelial (VE)-cadherin (VEC), upregulate genes with key roles in endothelial differentiation and stability...
December 12, 2017: Circulation Research
https://www.readbyqxmd.com/read/29232825/galectin-1-inhibitor-otx008-induces-tumor-vessel-normalization-and-tumor-growth-inhibition-in-human-head-and-neck-squamous-cell-carcinoma-models
#10
Nathan A Koonce, Robert J Griffin, Ruud P M Dings
Galectin-1 is a hypoxia-regulated protein and a prognostic marker in head and neck squamous cell carcinomas (HNSCC). Here we assessed the ability of non-peptidic galectin-1 inhibitor OTX008 to improve tumor oxygenation levels via tumor vessel normalization as well as tumor growth inhibition in two human HNSCC tumor models, the human laryngeal squamous carcinoma SQ20B and the human epithelial type 2 HEp-2. Tumor-bearing mice were treated with OTX008, Anginex, or Avastin and oxygen levels were determined by fiber-optics and molecular marker pimonidazole binding...
December 9, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29232823/improving-cerebral-blood-flow-after-arterial-recanalization-a-novel-therapeutic-strategy-in-stroke
#11
REVIEW
Mohamad El Amki, Susanne Wegener
Ischemic stroke is caused by a disruption in blood supply to a region of the brain. It induces dysfunction of brain cells and networks, resulting in sudden neurological deficits. The cause of stroke is vascular, but the consequences are neurological. Decades of research have focused on finding new strategies to reduce the neural damage after cerebral ischemia. However, despite the incredibly huge investment, all strategies targeting neuroprotection have failed to demonstrate clinical efficacy. Today, treatment for stroke consists of dealing with the cause, attempting to remove the occluding blood clot and recanalize the vessel...
December 9, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29232054/high-speed-microscopy-for-in-vivo-monitoring-of-lymph-dynamics
#12
Mustafa Sarimollaoglu, Amanda J Stolarz, Dmitry A Nedosekin, Brittney R Garner, Terry W Fletcher, Ekaterina I Galanzha, Nancy J Rusch, Vladimir P Zharov
The lymphatic system contributes to body homeostasis by clearing fluid, lipids, plasma proteins, and immune cells from the interstitial space. Many studies have been performed to understand lymphatic function under normal conditions and during disease. Nevertheless, a further improvement in quantification of lymphatic behavior is needed. Here, we present advanced bright-field microscopy for in vivo imaging of lymph vessels and automated quantification of lymphatic function at temporal resolution of 2 ms. Full frame videos were compressed and recorded continuously at up to 540 frames per second...
December 12, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/29229950/aneurysm-severity-is-increased-by-combined-mmp-7-deletion-and-n-cadherin-mimetic-ec4-fc-over-expression
#13
Cressida A Lyon, Helen Williams, Rosaria Bianco, Steven J Simmonds, Bethan A Brown, Kerry S Wadey, Frank C T Smith, Jason L Johnson, Sarah J George
There is an unmet need for treatments to reduce abdominal aortic aneurysm (AAA) progression. Vascular smooth muscle cell (VSMC) apoptosis precipitates AAA formation, whereas VSMC proliferation repairs the vessel wall. We previously demonstrated that over-expression of EC4-Fc (truncated N-cadherin), or deletion of matrix-metalloproteinase-7 (Mmp-7) reduced VSMC apoptosis in mouse atherosclerotic plaques. Additionally, MMP-7 promotes VSMC apoptosis by cleavage of N-cadherin. We investigated their combined effect on AAA formation...
December 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29227904/manipulating-the-structure-and-mechanical-properties-of-thermoplastic-polyurethane-polycaprolactone-hybrid-small-diameter-vascular-scaffolds-fabricated-via-electrospinning-using-an-assembled-rotating-collector
#14
Hao-Yang Mi, Xin Jing, Emily Yu, Xiaofeng Wang, Qian Li, Lih-Sheng Turng
The success of blood vessel transplants with vascular scaffolds (VSs) highly depends on their structure and mechanical properties. The fabrication of small diameter vascular scaffolds (SDVSs) mimicking the properties of native blood vessels has been a challenge. Herein, we propose a facile method to fabricate thermoplastic polyurethane (TPU)/polycaprolactone (PCL) hybrid SDVSs via electrospinning using a modified rotating collector. By varying the ratio between the TPU and the PCL, and changing the electrospinning volume, SDVSs with a wavy configuration and different properties could be obtained...
December 1, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29227848/development-and-evaluation-of-an-improved-laparoscopic-myomectomy-adopting-intracapsular-rotary-cut-procedures
#15
Shi-Lin Zhong, Li-Ping Zeng, Huan Li, Rui-Fang Wu
OBJECTIVES: To develop and evaluate the efficacy and feasibility of Intracapsular Rotary-cut Procedure (IRCP) in laparoscopic myomectomy (LM). STUDY DESIGN: It is a retrospective study conducted in Peking University Shenzhen Hospital (PUSH) in Shenzhen, China. A total of 96 patients who were treated with LM because of big and moderate size of myomas in PUSH from January 2013 and December 2015 were enrolled in this study. Among them 35 were managed with IRCP -integrated LM as the study group, while the other 61 were treated with normal LM as the control group...
November 27, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29227408/the-hybrid-technical-management-of-large-and-complicated-traumatic-arteriovenous-fistula-of-preauricular-region
#16
Jian Guo, Rucai Zhan, Yong Ren, Xiangjing Meng, Rengli Liu, Guijie Li, Dong Wang, Jinlong Sun
BACKGROUND: Arteriovenous fistula (AVF) is defined as an abnormal communication between the high flow arterial system and the low flow venous network, which directly connects the arterial feeding vessels and the near draining veins without normal intervening capillary bed. Arteriovenous fistula incurs in preauricular region is exceeding rare. Most of these fistulae occur as a result of an iatrogenic injury, the volume is small, feeding and draining vessels of feeding and draining are simple, and can be cured easily...
December 7, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29222954/evaluation-of-motion-artifact-metrics-for-coronary-ct-angiography
#17
Hongfeng Ma, Eric Gros, Aniko Szabo, Scott G Baginski, Zachary R Laste, Naveen M Kulkarni, Darin Okerlund, Taly G Schmidt
PURPOSE: This study quantified the performance of coronary artery motion artifact metrics relative to human observer ratings. Motion artifact metrics have been used as part of motion correction and best-phase selection algorithms for Coronary Computed Tomography Angiography (CCTA). However, the lack of ground truth makes it difficult to validate how well the metrics quantify the level of motion artifact. This study investigated five motion artifact metrics, including two novel metrics, using a dynamic phantom, clinical CCTA images, and an observer study that provided ground truth motion artifact scores from a series of pairwise comparisons...
December 9, 2017: Medical Physics
https://www.readbyqxmd.com/read/29222786/nerve-growth-factor-induced-angiogenesis-1-endothelial-cell-tube-formation-assay
#18
Philip Lazarovici, Adi Lahiani, Galit Gincberg, Dikla Haham, Arnon Fluksman, Ofra Benny, Cezary Marcinkiewicz, Peter I Lelkes
Nerve growth factor (NGF) is a neurotrophin promoting survival, proliferation, differentiation, and neuroprotection in the embryonal and adult nervous system. NGF also induces angiogenic effects in the cardiovascular system, which may be beneficial in engineering new blood vessels and for developing novel anti-angiogenesis therapies for cancer. Angiogenesis is a cellular process characterized by a number of events, including endothelial cell migration, invasion, and assembly into capillaries. In vitro endothelial tube formation assays are performed using primary human umbilical vein endothelial cells, human aortic endothelial cells, and other human or rodent primary endothelial cells isolated from the vasculature of both tumors and normal tissues...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29222229/visual-aids-for-patient-family-and-physician-decision-making-about-endovascular-thrombectomy-for-acute-ischemic-stroke
#19
Ivie Tokunboh, Marta Vales Montero, Matheus Fellipe Zopelaro Almeida, Latisha Sharma, Sidney Starkman, Viktor Szeder, Reza Jahan, David Liebeskind, Nestor Gonzalez, Andrew Demchuk, Michael T Froehler, Mayank Goyal, Maarten G Lansberg, Helmi Lutsep, Lee Schwamm, Jeffrey L Saver
BACKGROUND AND PURPOSE: Rapid decision making optimizes outcomes from endovascular thrombectomy for acute cerebral ischemia. Visual displays facilitate swift review of potential outcomes and can accelerate decision processes. METHODS: From patient-level, pooled randomized trial data, 100 person-icon arrays (Kuiper-Marshall personographs) were generated showing beneficial and adverse effects of endovascular thrombectomy for patients with acute cerebral ischemia and large vessel occlusion using (1) automated (algorithmic) and (2) expert-guided joint outcome table specification...
December 8, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29222111/rap1b-promotes-vegf-induced-endothelial-permeability-and-is-required-for-dynamic-regulation-of-endothelial-barrier
#20
Sribalaji Lakshmikanthan, Magdalena Sobczak, Sergio Li Calzi, Lynn Shaw, Maria B Grant, Magdalena Chrzanowska-Wodnicka
Vascular Endothelial Growth Factor (VEGF), a key angiogenic and permeability factor, plays an important role in new blood vessel formation. However, abnormal VEGF-induced VEGFR2 signaling leads to hyper-permeability. We demonstrated that Rap1, best known for promoting cell adhesion and vessel stability, is a critical regulator of VEGFR2-mediated angiogenic and shear-stress EC responses. To determine Rap1's role in endothelial barrier dynamics, we examined vascular permeability in EC-specific Rap1A- and Rap1B- knockout mice, cell-cell junction remodeling and EC monolayer resistivity in Rap1-deficient ECs under basal, inflammatory or elevated VEGF conditions...
December 8, 2017: Journal of Cell Science
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